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5. Multisocietal European consensus on the terminology, diagnosis, and management of patients with synchronous colorectal cancer and liver metastases: an E-AHPBA consensus in partnership with ESSO, ESCP, ESGAR, and CIRSE

Author

Siriwardena, A, Serrablo, A, Fretland, A, Wigmore, S, Ramia-Angel, J, Malik, H, Stattner, S, Soreide, K, Zmora, O, Meijerink, M, Kartalis, N, Lesurtel, M, Verhoef, K, Balakrishnan, A, Gruenberger, T, Jonas, E, Devar, J, Jamdar, S, Jones, R, Hilal, M, Andersson, B, Boudjema, K, Mullamitha, S, Stassen, L, Dasari, B, Frampton, A, Aldrighetti, L, Pellino, G, Buchwald, P, Gurses, B, Wasserberg, N, Gruenberger, B, Spiers, H, Jarnagin, W, Vauthey, J, Kokudo, N, Tejpar, S, Valdivieso, A, Adam, R, Lang, H, Smith, M, Deoliveira, M, Adair, A, Gilg, S, Swijnenburg, R, Jaekers, J, Jegatheeswaran, S, Buis, C, Parks, R, Bockhorn, M, Conroy, T, Petras, P, Primavesi, F, Chan, A, Cipriani, F, Rubbia-Brandt, L, Foster, L, Abdelaal, A, Yaqub, S, Rahbari, N, Fondevila, C, Abradelo, M, Kok, N, Tejedor, L, Martinez-Baena, D, Azoulay, D, Maglione, M, Serradilla-Martin, M, Azevedo, J, Romano, F, Line, P, Forcen, T, Panis, Y, Stylianides, N, Bale, R, Quaia, E, Yassin, N, Duque, V, Espin-Basany, E, Mellenhorst, J, Rees, A, Adeyeye, A, Tuynman, J, Simillis, C, Duff, S, Wilson, R, De Nardi, P, Palmer, G, Zakaria, A, Perra, T, Porcu, A, Tamini, N, Kelly, M, Metwally, I, Morarasu, S, Carbone, F, Estaire-Gomez, M, Perez, E, Seligmann, J, Gollins, S, Braun, M, Hessheimer, A, Alonso, V, Radhakrishna, G, Alam, N, Camposorias, C, Barriuoso, J, Ross, P, Ba-Ssalamah, A, Muthu, S, Filobbos, R, Nadarajah, V, Hattab, A, Newton, C, Barker, S, Sibbald, J, Hancock, J, de Liguori Carino, N, Deshpande, R, Lancellotti, F, Paterna, S, Gutierrez-Diez, M, Artigas, C, Siriwardena A. K., Serrablo A., Fretland A. A., Wigmore S. J., Ramia-Angel J. M., Malik H. Z., Stattner S., Soreide K., Zmora O., Meijerink M., Kartalis N., Lesurtel M., Verhoef K., Balakrishnan A., Gruenberger T., Jonas E., Devar J., Jamdar S., Jones R., Hilal M. A., Andersson B., Boudjema K., Mullamitha S., Stassen L., Dasari B. V. M., Frampton A. E., Aldrighetti L., Pellino G., Buchwald P., Gurses B., Wasserberg N., Gruenberger B., Spiers H. V. M., Jarnagin W., Vauthey J. -N., Kokudo N., Tejpar S., Valdivieso A., Adam R., Lang H., Smith M., deOliveira M. L., Adair A., Gilg S., Swijnenburg R. -J., Jaekers J., Jegatheeswaran S., Buis C., Parks R., Bockhorn M., Conroy T., Petras P., Primavesi F., Chan A. K. C., Cipriani F., Rubbia-Brandt L., Foster L., Abdelaal A., Yaqub S., Rahbari N., Fondevila C., Abradelo M., Kok N. F. M., Tejedor L., Martinez-Baena D., Azoulay D., Maglione M., Serradilla-Martin M., Azevedo J., Romano F., Line P. -D., Forcen T. A., Panis Y., Stylianides N., Bale R., Quaia E., Yassin N., Duque V., Espin-Basany E., Mellenhorst J., Rees A., Adeyeye A., Tuynman J. B., Simillis C., Duff S., Wilson R., De Nardi P., Palmer G. J., Zakaria A. D., Perra T., Porcu A., Tamini N., Kelly M. E., Metwally I., Morarasu S., Carbone F., Estaire-Gomez M., Perez E. M., Seligmann J., Gollins S., Braun M., Hessheimer A., Alonso V., Radhakrishna G., Alam N., Camposorias C., Barriuoso J., Ross P., Ba-Ssalamah A., Muthu S., Filobbos R., Nadarajah V., Hattab A., Newton C., Barker S., Sibbald J., Hancock J., de Liguori Carino N., Deshpande R., Lancellotti F., Paterna S., Gutierrez-Diez M., Artigas C., Siriwardena, A, Serrablo, A, Fretland, A, Wigmore, S, Ramia-Angel, J, Malik, H, Stattner, S, Soreide, K, Zmora, O, Meijerink, M, Kartalis, N, Lesurtel, M, Verhoef, K, Balakrishnan, A, Gruenberger, T, Jonas, E, Devar, J, Jamdar, S, Jones, R, Hilal, M, Andersson, B, Boudjema, K, Mullamitha, S, Stassen, L, Dasari, B, Frampton, A, Aldrighetti, L, Pellino, G, Buchwald, P, Gurses, B, Wasserberg, N, Gruenberger, B, Spiers, H, Jarnagin, W, Vauthey, J, Kokudo, N, Tejpar, S, Valdivieso, A, Adam, R, Lang, H, Smith, M, Deoliveira, M, Adair, A, Gilg, S, Swijnenburg, R, Jaekers, J, Jegatheeswaran, S, Buis, C, Parks, R, Bockhorn, M, Conroy, T, Petras, P, Primavesi, F, Chan, A, Cipriani, F, Rubbia-Brandt, L, Foster, L, Abdelaal, A, Yaqub, S, Rahbari, N, Fondevila, C, Abradelo, M, Kok, N, Tejedor, L, Martinez-Baena, D, Azoulay, D, Maglione, M, Serradilla-Martin, M, Azevedo, J, Romano, F, Line, P, Forcen, T, Panis, Y, Stylianides, N, Bale, R, Quaia, E, Yassin, N, Duque, V, Espin-Basany, E, Mellenhorst, J, Rees, A, Adeyeye, A, Tuynman, J, Simillis, C, Duff, S, Wilson, R, De Nardi, P, Palmer, G, Zakaria, A, Perra, T, Porcu, A, Tamini, N, Kelly, M, Metwally, I, Morarasu, S, Carbone, F, Estaire-Gomez, M, Perez, E, Seligmann, J, Gollins, S, Braun, M, Hessheimer, A, Alonso, V, Radhakrishna, G, Alam, N, Camposorias, C, Barriuoso, J, Ross, P, Ba-Ssalamah, A, Muthu, S, Filobbos, R, Nadarajah, V, Hattab, A, Newton, C, Barker, S, Sibbald, J, Hancock, J, de Liguori Carino, N, Deshpande, R, Lancellotti, F, Paterna, S, Gutierrez-Diez, M, Artigas, C, Siriwardena A. K., Serrablo A., Fretland A. A., Wigmore S. J., Ramia-Angel J. M., Malik H. Z., Stattner S., Soreide K., Zmora O., Meijerink M., Kartalis N., Lesurtel M., Verhoef K., Balakrishnan A., Gruenberger T., Jonas E., Devar J., Jamdar S., Jones R., Hilal M. A., Andersson B., Boudjema K., Mullamitha S., Stassen L., Dasari B. V. M., Frampton A. E., Aldrighetti L., Pellino G., Buchwald P., Gurses B., Wasserberg N., Gruenberger B., Spiers H. V. M., Jarnagin W., Vauthey J. -N., Kokudo N., Tejpar S., Valdivieso A., Adam R., Lang H., Smith M., deOliveira M. L., Adair A., Gilg S., Swijnenburg R. -J., Jaekers J., Jegatheeswaran S., Buis C., Parks R., Bockhorn M., Conroy T., Petras P., Primavesi F., Chan A. K. C., Cipriani F., Rubbia-Brandt L., Foster L., Abdelaal A., Yaqub S., Rahbari N., Fondevila C., Abradelo M., Kok N. F. M., Tejedor L., Martinez-Baena D., Azoulay D., Maglione M., Serradilla-Martin M., Azevedo J., Romano F., Line P. -D., Forcen T. A., Panis Y., Stylianides N., Bale R., Quaia E., Yassin N., Duque V., Espin-Basany E., Mellenhorst J., Rees A., Adeyeye A., Tuynman J. B., Simillis C., Duff S., Wilson R., De Nardi P., Palmer G. J., Zakaria A. D., Perra T., Porcu A., Tamini N., Kelly M. E., Metwally I., Morarasu S., Carbone F., Estaire-Gomez M., Perez E. M., Seligmann J., Gollins S., Braun M., Hessheimer A., Alonso V., Radhakrishna G., Alam N., Camposorias C., Barriuoso J., Ross P., Ba-Ssalamah A., Muthu S., Filobbos R., Nadarajah V., Hattab A., Newton C., Barker S., Sibbald J., Hancock J., de Liguori Carino N., Deshpande R., Lancellotti F., Paterna S., Gutierrez-Diez M., and Artigas C.

Abstract

Background: Contemporary management of patients with synchronous colorectal cancer and liver metastases is complex. The aim of this project was to provide a practical framework for care of patients with synchronous colorectal cancer and liver metastases, with a focus on terminology, diagnosis, and management. Methods: This project was a multiorganizational, multidisciplinary consensus. The consensus group produced statements which focused on terminology, diagnosis, and management. Statements were refined during an online Delphi process, and those with 70 per cent agreement or above were reviewed at a final meeting. Iterations of the report were shared by electronic mail to arrive at a final agreed document comprising 12 key statements. Results: Synchronous liver metastases are those detected at the time of presentation of the primary tumour. The term 'early metachronous metastases' applies to those absent at presentation but detected within 12 months of diagnosis of the primary tumour, the term 'late metachronous metastases' applies to those detected after 12 months. 'Disappearing metastases' applies to lesions that are no longer detectable on MRI after systemic chemotherapy. Guidance was provided on the recommended composition of tumour boards, and clinical assessment in emergency and elective settings. The consensus focused on treatment pathways, including systemic chemotherapy, synchronous surgery, and the staged approach with either colorectal or liver-directed surgery as first step. Management of pulmonary metastases and the role of minimally invasive surgery was discussed. Conclusion: The recommendations of this contemporary consensus provide information of practical value to clinicians managing patients with synchronous colorectal cancer and liver metastases.

Published
2023

6. The multi-societal European consensus on the terminology, diagnosis and management of patients with synchronous colorectal cancer and liver metastases: an E-AHPBA consensus in partnership with ESSO, ESCP, ESGAR, and CIRSE

Author

Siriwardena, A, Serrablo, A, Fretland, A, Wigmore, S, Ramia-Angel, J, Malik, H, Stattner, S, Soreide, K, Zmora, O, Meijerink, M, Kartalis, N, Lesurtel, M, Verhoef, C, Balakrishnan, A, Gruenberger, T, Jonas, E, Devar, J, Jamdar, S, Jones, R, Hilal, M, Andersson, B, Boudjema, K, Mullamitha, S, Stassen, L, Dasari, B, Frampton, A, Aldrighetti, L, Pellino, G, Buchwald, P, Gurses, B, Wasserberg, N, Gruenberger, B, Spiers, H, Jarnagin, W, Vauthey, J, Kokudo, N, Tejpar, S, Valdivieso, A, Adam, R, Hauke, L, Smith, M, Deoliveira, M, Adair, A, Gilg, S, Swijnenburg, R, Jaekers, J, Jegatheeswaran, S, Buis, C, Parks, R, Bockhorn, M, Conroy, T, Petras, P, Primavesi, F, Chan, A, Cipriani, F, Rubbia-Brandt, L, Foster, L, Abdelaal, A, Yaqub, S, Rahbari, N, Fondevila, C, Abradelo, M, Kok, N, Tejedor, L, Martinez-Baena, D, Azoulay, D, Maglione, M, Serradilla-Martin, M, Azevedo, J, Romano, F, Line, P, Forcen, T, Panis, Y, Stylianides, N, Bale, R, Quaia, E, Yassin, N, Duque, V, Espin-Basany, E, Mellenhorst, J, Rees, A, Adeyeye, A, Tuynman, J, Simillis, C, Duff, S, Wilson, R, De Nardi, P, Palmer, G, Zakaria, A, Perra, T, Porcu, A, Tamini, N, Kelly, M, Metwally, I, Morarasu, S, Carbone, F, Estaire-Gomez, M, Perez, E, Seligmann, J, Gollins, S, Braun, M, Hessheimer, A, Alonso, V, Radhakrishna, G, Alam, N, Camposorias, C, Barriuoso, J, Ross, P, Ba-Ssalamah, A, Muthu, S, Filobbos, R, Nadarajah, V, Hattab, A, Newton, C, Barker, S, Sibbald, J, Hancock, J, de Liguori Carino, N, Deshpande, R, Lancellotti, F, Paterna, S, Gutierrez-Diez, M, Artigas, C, Siriwardena A. K., Serrablo A., Fretland A. A., Wigmore S. J., Ramia-Angel J. M., Malik H. Z., Stattner S., Soreide K., Zmora O., Meijerink M., Kartalis N., Lesurtel M., Verhoef C., Balakrishnan A., Gruenberger T., Jonas E., Devar J., Jamdar S., Jones R., Hilal M. A., Andersson B., Boudjema K., Mullamitha S., Stassen L., Dasari B. V. M., Frampton A. E., Aldrighetti L., Pellino G., Buchwald P., Gurses B., Wasserberg N., Gruenberger B., Spiers H. V. M., Jarnagin W., Vauthey J. -N., Kokudo N., Tejpar S., Valdivieso A., Adam R., Hauke Lang, Smith M., deOliveira M. L., Adair A., Gilg S., Swijnenburg R. -J., Jaekers J., Jegatheeswaran S., Buis C., Parks R., Bockhorn M., Conroy T., Petras P., Primavesi F., Chan A. K. C., Cipriani F., Rubbia-Brandt L., Foster L., Abdelaal A., Yaqub S., Rahbari N., Fondevila C., Abradelo M., Kok N. F., Tejedor L., Martinez-Baena D., Azoulay D., Maglione M., Serradilla-Martin M., Azevedo J., Romano F., Line P. -D., Forcen T. A., Panis Y., Stylianides N., Bale R., Quaia E., Yassin N., Duque V., Espin-Basany E., Mellenhorst J., Rees A., Adeyeye A., Tuynman J. B., Simillis C., Duff S., Wilson R., De Nardi P., Palmer G. J., Zakaria A. D., Perra T., Porcu A., Tamini N., Kelly M. E., Metwally I., Morarasu S., Carbone F., Estaire-Gomez M., Perez E. M., Seligmann J., Gollins S., Braun M., Hessheimer A., Alonso V., Radhakrishna G., Alam N., Camposorias C., Barriuoso J., Ross P., Ba-Ssalamah A., Muthu S., Filobbos R., Nadarajah V., Hattab A., Newton C., Barker S., Sibbald J., Hancock J., de Liguori Carino N., Deshpande R., Lancellotti F., Paterna S., Gutierrez-Diez M., Artigas C., Siriwardena, A, Serrablo, A, Fretland, A, Wigmore, S, Ramia-Angel, J, Malik, H, Stattner, S, Soreide, K, Zmora, O, Meijerink, M, Kartalis, N, Lesurtel, M, Verhoef, C, Balakrishnan, A, Gruenberger, T, Jonas, E, Devar, J, Jamdar, S, Jones, R, Hilal, M, Andersson, B, Boudjema, K, Mullamitha, S, Stassen, L, Dasari, B, Frampton, A, Aldrighetti, L, Pellino, G, Buchwald, P, Gurses, B, Wasserberg, N, Gruenberger, B, Spiers, H, Jarnagin, W, Vauthey, J, Kokudo, N, Tejpar, S, Valdivieso, A, Adam, R, Hauke, L, Smith, M, Deoliveira, M, Adair, A, Gilg, S, Swijnenburg, R, Jaekers, J, Jegatheeswaran, S, Buis, C, Parks, R, Bockhorn, M, Conroy, T, Petras, P, Primavesi, F, Chan, A, Cipriani, F, Rubbia-Brandt, L, Foster, L, Abdelaal, A, Yaqub, S, Rahbari, N, Fondevila, C, Abradelo, M, Kok, N, Tejedor, L, Martinez-Baena, D, Azoulay, D, Maglione, M, Serradilla-Martin, M, Azevedo, J, Romano, F, Line, P, Forcen, T, Panis, Y, Stylianides, N, Bale, R, Quaia, E, Yassin, N, Duque, V, Espin-Basany, E, Mellenhorst, J, Rees, A, Adeyeye, A, Tuynman, J, Simillis, C, Duff, S, Wilson, R, De Nardi, P, Palmer, G, Zakaria, A, Perra, T, Porcu, A, Tamini, N, Kelly, M, Metwally, I, Morarasu, S, Carbone, F, Estaire-Gomez, M, Perez, E, Seligmann, J, Gollins, S, Braun, M, Hessheimer, A, Alonso, V, Radhakrishna, G, Alam, N, Camposorias, C, Barriuoso, J, Ross, P, Ba-Ssalamah, A, Muthu, S, Filobbos, R, Nadarajah, V, Hattab, A, Newton, C, Barker, S, Sibbald, J, Hancock, J, de Liguori Carino, N, Deshpande, R, Lancellotti, F, Paterna, S, Gutierrez-Diez, M, Artigas, C, Siriwardena A. K., Serrablo A., Fretland A. A., Wigmore S. J., Ramia-Angel J. M., Malik H. Z., Stattner S., Soreide K., Zmora O., Meijerink M., Kartalis N., Lesurtel M., Verhoef C., Balakrishnan A., Gruenberger T., Jonas E., Devar J., Jamdar S., Jones R., Hilal M. A., Andersson B., Boudjema K., Mullamitha S., Stassen L., Dasari B. V. M., Frampton A. E., Aldrighetti L., Pellino G., Buchwald P., Gurses B., Wasserberg N., Gruenberger B., Spiers H. V. M., Jarnagin W., Vauthey J. -N., Kokudo N., Tejpar S., Valdivieso A., Adam R., Hauke Lang, Smith M., deOliveira M. L., Adair A., Gilg S., Swijnenburg R. -J., Jaekers J., Jegatheeswaran S., Buis C., Parks R., Bockhorn M., Conroy T., Petras P., Primavesi F., Chan A. K. C., Cipriani F., Rubbia-Brandt L., Foster L., Abdelaal A., Yaqub S., Rahbari N., Fondevila C., Abradelo M., Kok N. F., Tejedor L., Martinez-Baena D., Azoulay D., Maglione M., Serradilla-Martin M., Azevedo J., Romano F., Line P. -D., Forcen T. A., Panis Y., Stylianides N., Bale R., Quaia E., Yassin N., Duque V., Espin-Basany E., Mellenhorst J., Rees A., Adeyeye A., Tuynman J. B., Simillis C., Duff S., Wilson R., De Nardi P., Palmer G. J., Zakaria A. D., Perra T., Porcu A., Tamini N., Kelly M. E., Metwally I., Morarasu S., Carbone F., Estaire-Gomez M., Perez E. M., Seligmann J., Gollins S., Braun M., Hessheimer A., Alonso V., Radhakrishna G., Alam N., Camposorias C., Barriuoso J., Ross P., Ba-Ssalamah A., Muthu S., Filobbos R., Nadarajah V., Hattab A., Newton C., Barker S., Sibbald J., Hancock J., de Liguori Carino N., Deshpande R., Lancellotti F., Paterna S., Gutierrez-Diez M., and Artigas C.

Abstract

Background: Contemporary management of patients with synchronous colorectal cancer and liver metastases is complex. The aim of this project was to provide a practical framework for care of patients with synchronous colorectal cancer and liver metastases with a focus on terminology, diagnosis and management. Methods: This project was a multi-organisational, multidisciplinary consensus. The consensus group produced statements which focused on terminology, diagnosis and management. Statements were refined during an online Delphi process and those with 70% agreement or above were reviewed at a final meeting. Iterations of the report were shared by electronic mail to arrive at a final agreed document comprising twelve key statements. Results: Synchronous liver metastases are those detected at the time of presentation of the primary tumour. The term “early metachronous metastases” applies to those absent at presentation but detected within 12 months of diagnosis of the primary tumour with “late metachronous metastases” applied to those detected after 12 months. Disappearing metastases applies to lesions which are no longer detectable on MR scan after systemic chemotherapy. Guidance was provided on the recommended composition of tumour boards and clinical assessment in emergency and elective settings. The consensus focused on treatment pathways including systemic chemotherapy, synchronous surgery and the staged approach with either colorectal or liver-directed surgery as first step. Management of pulmonary metastases and the role of minimally invasive surgery was discussed. Conclusions: The recommendations of this contemporary consensus provide information of practical value to clinicians managing patients with synchronous colorectal cancer and liver metastases.

Published
2023

7. P680: SARCOPENIA EVALUATED BY CT SCAN IS ASSOCIATED WITH SHORTER SURVIVAL IN PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKEMIA TREATED WITH TARGETED THERAPIES. A PROSPECTIVE STUDY.

Author

Visentin, A., primary, Crimì, F., additional, Corso, A., additional, Angelone, R., additional, Cavarretta, C. A., additional, Cellini, A., additional, Angotzi, F., additional, Ruocco, V., additional, Pravato, S., additional, Quaia, E., additional, and Trentin, L., additional

Published
2022
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18. Subtyping of Primary Aldosteronism in the AVIS-2 Study: Assessment of Selectivity and Lateralization

Author

Rossitto, G., Amar, L., Azizi, M., Riester, A., Reincke, M., Degenhart, C., Widimsky, J., Naruse, M., Deinum, J., Schultze Kool, L., Kocjan, T., Negro, A., Rossi, E., Kline, G., Tanabe, A., Satoh, F., Rump, L.C., Vonend, O., Willenberg, H.S., Fuller, P., Yang, J., Chee, N.Y. Nian, Magill, S.B., Shafigullina, Z., Quinkler, M., Oliveras, A., Chang, C.C., Wu, V.C., Somloova, Z., Maiolino, G., Barbiero, G., Battistel, M., Lenzini, L., Quaia, E., Pessina, A.C., Rossi, G.P., Rossitto, G., Amar, L., Azizi, M., Riester, A., Reincke, M., Degenhart, C., Widimsky, J., Naruse, M., Deinum, J., Schultze Kool, L., Kocjan, T., Negro, A., Rossi, E., Kline, G., Tanabe, A., Satoh, F., Rump, L.C., Vonend, O., Willenberg, H.S., Fuller, P., Yang, J., Chee, N.Y. Nian, Magill, S.B., Shafigullina, Z., Quinkler, M., Oliveras, A., Chang, C.C., Wu, V.C., Somloova, Z., Maiolino, G., Barbiero, G., Battistel, M., Lenzini, L., Quaia, E., Pessina, A.C., and Rossi, G.P.

Abstract

Contains fulltext : 220552.pdf (Publisher’s version ) (Closed access), CONTEXT: Adrenal venous sampling (AVS) is the key test for subtyping primary aldosteronism (PA), but its interpretation varies widely across referral centers and this can adversely affect the management of PA patients. OBJECTIVES: To investigate in a real-life study the rate of bilateral success and identification of unilateral aldosteronism and their impact on blood pressure outcomes in PA subtyped by AVS. DESIGN AND SETTINGS: In a retrospective analysis of the largest international registry of individual AVS data (AVIS-2 study), we investigated how different cut-off values of the selectivity index (SI) and lateralization index (LI) affected rate of bilateral success, identification of unilateral aldosteronism, and blood pressure outcomes. RESULTS: AVIS-2 recruited 1625 individual AVS studies performed between 2000 and 2015 in 19 tertiary referral centers. Under unstimulated conditions, the rate of biochemically confirmed bilateral AVS success progressively decreased with increasing SI cut-offs; furthermore, with currently used LI cut-offs, the rate of identified unilateral PA leading to adrenalectomy was as low as <25%. A within-patient pairwise comparison of 402 AVS performed both under unstimulated and cosyntropin-stimulated conditions showed that cosyntropin increased the confirmed rate of bilateral selectivity for SI cut-offs >/= 2.0, but reduced lateralization rates (P < 0.001). Post-adrenalectomy outcomes were not improved by use of cosyntropin or more restrictive diagnostic criteria. CONCLUSION: Commonly used SI and LI cut-offs are associated with disappointingly low rates of biochemically defined AVS success and identified unilateral PA. Evidence-based protocols entailing less restrictive interpretative cut-offs might optimize the clinical use of this costly and invasive test. (J Clin Endocrinol Metab XX: 0-0, 2020).

Published
2020

19. Subtyping of primary aldosteronism in the AVIS-2 study: Assessment of selectivity and lateralization.

Author

Battistel M., Shafigullina Z., Quinkler M., Oliveras A., Chang C.-C., Wu V.C., Somloova Z., Maiolino G., Barbiero G., Lenzini L., Quaia E., Pessina A.C., Rossi G.P., Kline G., Rossitto G., Amar L., Azizi M., Riester A., Reincke M., Degenhart C., Widimsky J., Naruse M., Deinum J., Schultzekool L., Kocjan T., Negro A., Rossi E., Tanabe A., Satoh F., Rump L.C., Vonend O., Willenberg H.S., Fuller P., Yang J., Chee N.Y.N., Magill S.B., Battistel M., Shafigullina Z., Quinkler M., Oliveras A., Chang C.-C., Wu V.C., Somloova Z., Maiolino G., Barbiero G., Lenzini L., Quaia E., Pessina A.C., Rossi G.P., Kline G., Rossitto G., Amar L., Azizi M., Riester A., Reincke M., Degenhart C., Widimsky J., Naruse M., Deinum J., Schultzekool L., Kocjan T., Negro A., Rossi E., Tanabe A., Satoh F., Rump L.C., Vonend O., Willenberg H.S., Fuller P., Yang J., Chee N.Y.N., and Magill S.B.

Abstract

Context: Adrenal venous sampling (AVS) is the key test for subtyping primary aldosteronism (PA), but its interpretation varies widely across referral centers and this can adversely affect the management of PA patients. Objective(s): To investigate in a real-life study the rate of bilateral success and identification of unilateral aldosteronism and their impact on blood pressure outcomes in PA subtyped by AVS. Design and settings: In a retrospective analysis of the largest international registry of individual AVS data (AVIS-2 study), we investigated how different cut-off values of the selectivity index (SI) and lateralization index (LI) affected rate of bilateral success, identification of unilateral aldosteronism, and blood pressure outcomes. Result(s): AVIS-2 recruited 1625 individual AVS studies performed between 2000 and 2015 in 19 tertiary referral centers. Under unstimulated conditions, the rate of biochemically confirmed bilateral AVS success progressively decreased with increasing SI cut-offs; furthermore, with currently used LI cut-offs, the rate of identified unilateral PA leading to adrenalectomy was as low as <25%. A within-patient pairwise comparison of 402 AVS performed both under unstimulated and cosyntropin-stimulated conditions showed that cosyntropin increased the confirmed rate of bilateral selectivity for SI cut-offs >= 2.0, but reduced lateralization rates (P < 0.001). Post-adrenalectomy outcomes were not improved by use of cosyntropin or more restrictive diagnostic criteria. Conclusion(s): Commonly used SI and LI cut-offs are associated with disappointingly low rates of biochemically defined AVS success and identified unilateral PA. Evidence-based protocols entailing less restrictive interpretative cut-offs might optimize the clinical use of this costly and invasive test.Copyright © Endocrine Society 2019. All rights reserved.

Published
2020

20. Clinical mammography at the SYRMEP beam line

Author

Castelli, E., Arfelli, F., Dreossi, D., Longo, R., Rokvic, T., Cova, M.A., Quaia, E., Tonutti, M., Zanconati, F., Abrami, A., Chenda, V., Menk, R.H., Quai, E., Tromba, G., Bregant, P., and de Guarrini, F.

Published
2007
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30. P384Ventricular arrhythmias and left ventricular dilatation in a young pregnant woman: the additional diagnostic value of cardiovascular magnetic resonance

Author

Riccardo Bariani, R B, primary, Alberto Cipriani, A C, additional, Giulia Brunetti, G B, additional, Benedetta Giorgi, B G, additional, Emilio Quaia, E Q, additional, Sabino Iliceto, S I, additional, Anna Baritussio, A B, additional, Ilaria Rigato, I R, additional, Domenico Corrado, D C, additional, Martina Perazzolo Marra, M P M, additional, and Barbara Bauce, B B, additional

Published
2019
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31. 529Relationship between ventricular mechanics and fibro-fatty replacement on cardiac magnetic resonance in arrhythmogenic cardiomyopathy.

Author

Perazzolo Marra, M, primary, Zanetti, C, additional, Bariani, R, additional, Cipriani, A, additional, Rizzon, G, additional, Giorgi, B, additional, Lacognata, C, additional, Quaia, E, additional, Aliberti, C, additional, Basso, C, additional, Corrado, D, additional, Rigato, I, additional, Bauce, B, additional, Tona, F, additional, and Iliceto, S, additional

Published
2019
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33. P357Never stop at the first diagnosis, though very plausible

Author

Quinto, L, primary, Cipriani, A, additional, De Lazzari, M, additional, Simeti, G, additional, Migliore, F, additional, Lacognata, C, additional, Zucchetta, P, additional, Aliberti, C, additional, Quaia, E, additional, Iliceto, S, additional, and Perazzolo Marra, M, additional

Published
2019
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34. P110Twin CMRs, the same diagnosis?

Author

Alderighi, C, primary, Baritussio, A, additional, De Lazzari, M, additional, Collevecchio, A, additional, Giorgi, B, additional, Quaia, E, additional, Tarantini, G, additional, Berno, T, additional, Babuin, L, additional, Basso, C, additional, Iliceto, S, additional, and Marra, M P, additional

Published
2019
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35. Renal Failure

Author

Quaia, E, Quaia, Emilio, and Quaia E

Subjects
Renal failure, Kideny, Imaging, imaging
Abstract

N/A

Published
2014

36. Characterization of focal liver lesions

Author

QUAIA E, D, ONOFRIO M, PALUMBO A, CALLIADA F, ROSSI S, POZZI MUCELLI R., BARTOLOTTA, Tommaso Vincenzo, MIDIRI, Massimo, QUAIA E., QUAIA E, ONOFRIO M, BARTOLOTTA TV, PALUMBO A, MIDIRI M, CALLIADA F, ROSSI S, and POZZI MUCELLI R

Published
2005

37. La mappa acustica strategica dell'agglomerato di Milano: dai dati di partenza al modello acustico

Author

ZAMBON, GIOVANNI, Radaelli, S, Quaia, E, Coppi, P, Dipietro, C., Zambon, G, Radaelli, S, Quaia, E, Coppi, P, and Dipietro, C

Subjects
modellizzazione, mappa, acustica, FIS/07 - FISICA APPLICATA (A BENI CULTURALI, AMBIENTALI, BIOLOGIA E MEDICINA)
Abstract

La molteplicità delle infrastrutture presenti e dei relativi gestori rende la realizzazione della mappa acustica strategica di Milano estremamente complessa. Lo scopo del presente lavoro è quello di mostrare i criteri adottati in fase di strutturazione del modello acustico a partire dalle diverse tipologie di dati acquisiti, preliminarmente raccolti ed elaborati all’interno di un Sistema Informativo Territoriale. In particolare vengono illustrate le soluzioni tecniche intraprese sia nell’organizzazione delle informazioni all’interno del SIT, con particolare riferimento all’elaborazione dei dati di popolazione e dei dati riguardanti i flussi di traffico, sia nell’utilizzo delle stesse nel software di simulazione (caratterizzazione delle diverse sorgenti e dell’ambiente di propagazione e scelta dei parametri di calcolo). Nello sviluppo del progetto ci si è basati sulle linee guida contenute nella “Good Practice Guide for Strategic Noise Mapping” (WG-AEN).

Published
2009

42. Management of low voltage grids with high penetration of distributed generation: Concepts, implementations and experiments

Author

Bertani, A, Borghetti, A, Bossi, C, Lamquet, O, Masucco, S, Morini, A, Nucci, CA, Paolone, M, Quaia, E, Silvestro, E, DE BIASE, LUCIA, Bertani, A, Borghetti, A, Bossi, C, Lamquet, O, Masucco, S, Morini, A, Nucci, C, Paolone, M, Quaia, E, Silvestro, E, and DE BIASE, L

Subjects
Neural Network, Distributed generation
Abstract

The interconnection of distributed generators in low voltage (LV) networks, together with storage systems, could cause a substantial change in grid operational practice: currently a rising idea proposes to treat generators, storage systems and even loads as distributed energy resources (DER), able to supply services to the grid and accept on-line requests. To emphasise the advantages of Distributed Generation (DG) it is necessary to face the problem with a system approach. In this work both type of services, namely those provided by each generator and those deriving from the co-ordination of different resources, have been investigated. The option represented by a complex master-slave configuration has been discarded in order to avoid its fast communication and control requirements. Instead a prototype based on a centralised resource management solution and a somewhat plug-and-play functionality for each generator has been developed. For this purpose, different control systems have been implemented in order to act during fast transient dynamics due to random load or configuration changes, or to manage the slow modifications of the system conditions due to daily, weekly and seasonal load variations. The regulators of every distributed resource are requested to give response to fast and unpredictable transient dynamics, i.e. to participate to voltage and frequency regulations, harmonic compensations and phase balancing, while a central dispatcher has been conceived as to periodically update the regulators set-points in order to exploit the capabilities of each distributed resource either for present and foreseen grid operating conditions. For voltage and frequency regulations, a specific droop control algorithm has been designed so to be implemented on board of generators connected to the LV grid by an inverter device. In the conceived scenario, each machine, working in parallel with the others, takes on part of the regulation according to its capabilities. For the optimal update of the distributed resources' operating conditions, the developed central dispatcher incorporates the following main functions: short-term forecast of the power produced by renewable energy sources (RES), short-term load forecast and day-ahead load profile prediction, distribution system state estimation, day-ahead economic dispatching and on-line scheduling of the optimal distributed resources' operating conditions. The developed regulators and central dispatcher prototypes have been installed in a test facility set up at Cesi, where several distributed generators of different technologies, storage devices and loads have been interconnected with secondary LV network that can be arranged in different configurations. Some preliminary experiments have been carried out in order to assess the system performances. In particular, according to the view that the high penetration of DG could become an opportunity rather than a problem, as it is frequently considered, the results of this experimental activity show that distributed resources could be suitably used in order to control grid voltage profiles, power flows, and to handling intentional and unintentional islanding condition after separation of the LV grid from the MV distribution grid. The research activity described in this paper was supported in the framework of a National Research Project named GENDIS 21 - Distributed Generation for the Improvement of Power Quality and Environment.

Published
2006

44. Contrast Enhancement Patterns in Benign Liver Tumors Insonated after Microbubble Contrast Agent Injection: Comparison of Diagnostic Performance of Baseline and Contrast-enhanced US in the Histotype Diagnosis

Author

Quaia, E, Bartolotta, Tv, Midiri, M, Palumbo, A, Gava, S, Cova, Ma., Quaia, Emilio, Bartolotta, Tv, Midiri, M, Palumbo, A, Gava, S, Cova, MARIA ASSUNTA, QUAIA E, BARTOLOTTA TV, M MIDIRI, A PALOMBO, S GAVA, and MA COVA

Subjects
ultrasound, liver lesions, microbubble, liver lesion
Published
2005

45. Vesicoureteral reflux

Author

Quaia, E, Quaia E, and Quaia, Emilio

Subjects
ultrasound, Reflux, Kidney, microbubbles
Published
2005

46. Renal arteries

Author

Quaia, E, Quaia E, and Quaia, Emilio

Subjects
renal arteries, renal arterie, microbubbles
Published
2005

49. Digital chest tomosynthesis: impact on patient management

Author

Quaia, E, Baratella, E, Lorusso, A, Casagrande, F, Ulcigrai, V, Cova, Ma, ESR Vienna, Quaia, Emilio, Baratella, E, Lorusso, A, Casagrande, F, Ulcigrai, V, and Cova, MARIA ASSUNTA

Subjects
Chest, tomosynthesis, diagnosis, tomosynthesi
Published
2012

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