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7 results on '"Queyrel N"'

1. L’avenir des marqueurs tumoraux : l’exploitation de leur cinétique. Étude CNBH 2004–2006, de la rédaction d’un cahier des charges aux essais des logiciels existants

Author

Leban, M., Thuillier, F., Basuyau, J.-P., Braidy, C., Billion, P., Boehrer, J.-L., Calestréme, P., Coquelin, H., Coulhon, M.-P., Daunizeau, A., Eche, N., Fulla, Y., Hanser, A.-M., Hym, B., Landreaud, M., Laplace, M., Macchi, V., Michotey, O., Poupon, C., Queyrel, N., Riedinger, J.-M., and Turret, M.-M.

Published
2008
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6. Testosterone measured by 10 immunoassays and by isotope-dilution gas chromatography-mass spectrometry in sera from 116 men, women, and children.

Author

Taieb J, Mathian B, Millot F, Patricot MC, Mathieu E, Queyrel N, Lacroix I, Somma-Delpero C, and Boudou P

Subjects
Adult, Aged, Autoanalysis methods, Child, Female, Gas Chromatography-Mass Spectrometry, Humans, Immunoassay methods, Male, Middle Aged, Radioisotope Dilution Technique, Testosterone blood
Abstract

Background: Commercially available testosterone immunoassays give divergent results, especially at the low concentrations seen in women. We compared immunoassays and a nonimmunochemical method that could quantify low testosterone concentrations., Methods: We measured serum testosterone in 50 men, 55 women, and 11 children with use of eight nonisotopic immunoassays, two isotopic immunoassays, and isotope-dilution gas chromatography-mass spectrometry (ID/GC-MS)., Results: Compared with ID/GC-MS, 7 of the 10 immunoassays tested overestimated testosterone concentrations in samples from women; mean immunoassay results were 46% above those obtained by ID/GC-MS. The immunoassays underestimated testosterone concentrations in samples from men, giving mean results 12% below those obtained by ID/GC-MS. In women, at concentrations of 0.6-7.2 nmol/L, 3 of the 10 immunoassays gave positive mean differences >2.0 nmol/L (range, -0.7 to 3.3 nmol/L) compared with ID/GC-MS; in men at concentrations of 8.2-58 nmol/L, 3 of the 10 immunoassays tested gave mean differences >4.0 nmol/L (range, -4.8 to 2.6 nmol/L)., Conclusion: None of the immunoassays tested was sufficiently reliable for the investigation of sera from children and women, in whom very low (0.17 nmol/L) and low (<1.7 nmol/L) testosterone concentrations are expected.

Published
2003
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7. [Validity of immunochemical methods for bloody progesterone: a study performed in 1998].

Author

Patricot MC, Badonnel Y, Boudou P, Lacroix I, Mathian B, Mathieu E, Millot F, Queyrel N, Somma-Delpero C, and Taieb J

Subjects
Acridines, Alkaline Phosphatase, Carbon Isotopes, Child, Europium, Fluorescence, Fluorescent Dyes, Gas Chromatography-Mass Spectrometry standards, Horseradish Peroxidase, Humans, Immunochemistry standards, Indicators and Reagents, Luminescent Measurements, Reproducibility of Results, Ruthenium, Progesterone blood
Abstract

The aim of this study was to compare, with manufacturer's agreement, twelve direct and non-isotopic commercial assays of progesterone. We have evaluated the analytical performances: low limit detection, imprecision, accuracy (recovery and dilution tests) and we have tested some patient samples. Results were compared to a reference method using isotope dilution Gas Chromatography and Mass Spectrometry combination (GC-MS). For each assay, analytical qualities and defaults are established. Large differences are found between progesterone concentration measured on the same sample with the different methods essentially for the low concentrations. Comparison with GC-MS raised questions about the accuracy of the different assays. This work will be aid laboratories to their choice and/or validation.

Published
1999

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