982 results on '"Quirós, J Ramón"'
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2. Healthy lifestyle change and all-cause and cancer mortality in the European Prospective Investigation into Cancer and Nutrition cohort
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Matta, Komodo, Viallon, Vivian, Botteri, Edoardo, Peveri, Giulia, Dahm, Christina, Nannsen, Anne Østergaard, Olsen, Anja, Tjønneland, Anne, Elbaz, Alexis, Artaud, Fanny, Marques, Chloé, Kaaks, Rudolf, Katzke, Verena, Schulze, Matthias B., Llanaj, Erand, Masala, Giovanna, Pala, Valeria, Panico, Salvatore, Tumino, Rosario, Ricceri, Fulvio, Derksen, Jeroen W. G., Nøst, Therese Haugdahl, Sandanger, Torkjel M., Borch, Kristin Benjaminsen, Quirós, J. Ramón, Castro-Espin, Carlota, Sánchez, Maria-José, Atxega, Amaia Aizpurua, Cirera, Lluís, Guevara, Marcela, Manjer, Jonas, Tin Tin, Sandar, Heath, Alicia, Touvier, Mathilde, Goldberg, Marcel, Weiderpass, Elisabete, Gunter, Marc J., Freisling, Heinz, Riboli, Elio, and Ferrari, Pietro
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- 2024
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3. A body shape index (ABSI) is associated inversely with post-menopausal progesterone-receptor-negative breast cancer risk in a large European cohort
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Christakoudi, Sofia, Tsilidis, Konstantinos K., Dossus, Laure, Rinaldi, Sabina, Weiderpass, Elisabete, Antoniussen, Christian S., Dahm, Christina C., Tjønneland, Anne, Mellemkjær, Lene, Katzke, Verena, Kaaks, Rudolf, Schulze, Matthias B., Masala, Giovanna, Grioni, Sara, Panico, Salvatore, Tumino, Rosario, Sacerdote, Carlotta, May, Anne M., Monninkhof, Evelyn M., Quirós, J. Ramón, Bonet, Catalina, Sánchez, Maria-Jose, Amiano, Pilar, Chirlaque, María-Dolores, Guevara, Marcela, Rosendahl, Ann H., Stocks, Tanja, Perez-Cornago, Aurora, Tin Tin, Sandar, Heath, Alicia K., Aglago, Elom K., Peruchet-Noray, Laia, Freisling, Heinz, and Riboli, Elio
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- 2023
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4. Associations between dietary inflammatory scores and biomarkers of inflammation in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort
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Lécuyer, Lucie, Laouali, Nasser, Viallon, Vivian, Artaud, Fanny, Hébert, James R., Shivappa, Nitin, Agudo, Antonio, Tjønneland, Anne, Mellemkjær, Lene, Kaaks, Rudolf, Katzke, Verena A., Schulze, Matthias B., Frenoy, Pauline, Mancini, Francesca Romana, De Magistris, Maria Santucci, Macciotta, Alessandra, Masala, Giovanna, Agnoli, Claudia, Tumino, Rosario, Boer, Jolanda M.A., Verschuren, W.M. Monique, Enget Jensen, Torill M., Olsen, Karina Standahl, Skeie, Guri, Chirlaque, María-Dolores, Petrova, Dafina, Castro-Espin, Carlota, Quirós, J. Ramón, Guevara, Marcela, Amiano, Pilar, Borné, Yan, Sandström, Maria, Nilsson, Lena Maria, Heath, Alicia K., Mayen, Ana-Lucia, Huybrechts, Inge, Weiderpass, Elisabete, Boutron-Ruault, Marie-Christine, Dossus, Laure, Rinaldi, Sabina, and Truong, Thérèse
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- 2023
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5. A Prospective Diet-Wide Association Study for Risk of Colorectal Cancer in EPIC
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Papadimitriou, Nikos, Bouras, Emmanouil, van den Brandt, Piet A., Muller, David C., Papadopoulou, Areti, Heath, Alicia K., Critselis, Elena, Gunter, Marc J., Vineis, Paolo, Ferrari, Pietro, Weiderpass, Elisabete, Boeing, Heiner, Bastide, Nadia, Merritt, Melissa A., Lopez, David S., Bergmann, Manuela M., Perez-Cornago, Aurora, Schulze, Matthias, Skeie, Guri, Srour, Bernard, Eriksen, Anne Kirstine, Boden, Stina, Johansson, Ingegerd, Nøst, Therese Haugdahl, Lukic, Marco, Ricceri, Fulvio, Ericson, Ulrika, Huerta, José María, Dahm, Christina C., Agnoli, Claudia, Amiano, Pilar Exezarreta, Tjønneland, Anne, Gurrea, Aurelio Barricarte, Bueno-de-Mesquita, Bas, Ardanaz, Eva, Berntsson, Jonna, Sánchez, Maria-Jose, Tumino, Rosario, Panico, Salvatore, Katzke, Verena, Jakszyn, Paula, Masala, Giovanna, Derksen, Jeroen W.G., Quirós, J. Ramón, Severi, Gianluca, Cross, Amanda J., Riboli, Ellio, Tzoulaki, Ioanna, and Tsilidis, Konstantinos K.
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- 2022
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6. Low Free Testosterone and Prostate Cancer Risk: A Collaborative Analysis of 20 Prospective Studies
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Watts, Eleanor L, Appleby, Paul N, Perez-Cornago, Aurora, Bueno-de-Mesquita, H Bas, Chan, June M, Chen, Chu, Cohn, Barbara A, Cook, Michael B, Flicker, Leon, Freedman, Neal D, Giles, Graham G, Giovannucci, Edward, Gislefoss, Randi E, Hankey, Graeme J, Kaaks, Rudolf, Knekt, Paul, Kolonel, Laurence N, Kubo, Tatsuhiko, Le Marchand, Loïc, Luben, Robert N, Luostarinen, Tapio, Männistö, Satu, Metter, E Jeffrey, Mikami, Kazuya, Milne, Roger L, Ozasa, Kotaro, Platz, Elizabeth A, Quirós, J Ramón, Rissanen, Harri, Sawada, Norie, Stampfer, Meir, Stanczyk, Frank Z, Stattin, Pär, Tamakoshi, Akiko, Tangen, Catherine M, Thompson, Ian M, Tsilidis, Konstantinos K, Tsugane, Shoichiro, Ursin, Giske, Vatten, Lars, Weiss, Noel S, Yeap, Bu B, Allen, Naomi E, Key, Timothy J, and Travis, Ruth C
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Cancer ,Clinical Research ,Prevention ,Urologic Diseases ,Prostate Cancer ,Aging ,Aetiology ,2.1 Biological and endogenous factors ,Adult ,Aged ,Biomarkers ,Case-Control Studies ,Down-Regulation ,Humans ,Male ,Middle Aged ,Neoplasm Grading ,Prospective Studies ,Prostatic Neoplasms ,Protective Factors ,Risk Assessment ,Risk Factors ,Testosterone ,Time Factors ,Androgens Pooled analysis ,Prospective studies ,Prostate cancer ,Sex hormones ,Epidemiology ,Androgens ,Pooled analysis ,Clinical Sciences ,Urology & Nephrology - Abstract
BackgroundExperimental and clinical evidence implicates testosterone in the aetiology of prostate cancer. Variation across the normal range of circulating free testosterone concentrations may not lead to changes in prostate biology, unless circulating concentrations are low. This may also apply to prostate cancer risk, but this has not been investigated in an epidemiological setting.ObjectiveTo examine whether men with low concentrations of circulating free testosterone have a reduced risk of prostate cancer.Design, setting, and participantsAnalysis of individual participant data from 20 prospective studies including 6933 prostate cancer cases, diagnosed on average 6.8 yr after blood collection, and 12 088 controls in the Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group.Outcome measurements and statistical analysisOdds ratios (ORs) of incident overall prostate cancer and subtypes by stage and grade, using conditional logistic regression, based on study-specific tenths of calculated free testosterone concentration.Results and limitationsMen in the lowest tenth of free testosterone concentration had a lower risk of overall prostate cancer (OR=0.77, 95% confidence interval [CI] 0.69-0.86; p
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- 2018
7. Prediction of acute myeloid leukaemia risk in healthy individuals.
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Abelson, Sagi, Collord, Grace, Ng, Stanley WK, Weissbrod, Omer, Mendelson Cohen, Netta, Niemeyer, Elisabeth, Barda, Noam, Zuzarte, Philip C, Heisler, Lawrence, Sundaravadanam, Yogi, Luben, Robert, Hayat, Shabina, Wang, Ting Ting, Zhao, Zhen, Cirlan, Iulia, Pugh, Trevor J, Soave, David, Ng, Karen, Latimer, Calli, Hardy, Claire, Raine, Keiran, Jones, David, Hoult, Diana, Britten, Abigail, McPherson, John D, Johansson, Mattias, Mbabaali, Faridah, Eagles, Jenna, Miller, Jessica K, Pasternack, Danielle, Timms, Lee, Krzyzanowski, Paul, Awadalla, Philip, Costa, Rui, Segal, Eran, Bratman, Scott V, Beer, Philip, Behjati, Sam, Martincorena, Inigo, Wang, Jean CY, Bowles, Kristian M, Quirós, J Ramón, Karakatsani, Anna, La Vecchia, Carlo, Trichopoulou, Antonia, Salamanca-Fernández, Elena, Huerta, José M, Barricarte, Aurelio, Travis, Ruth C, Tumino, Rosario, Masala, Giovanna, Boeing, Heiner, Panico, Salvatore, Kaaks, Rudolf, Krämer, Alwin, Sieri, Sabina, Riboli, Elio, Vineis, Paolo, Foll, Matthieu, McKay, James, Polidoro, Silvia, Sala, Núria, Khaw, Kay-Tee, Vermeulen, Roel, Campbell, Peter J, Papaemmanuil, Elli, Minden, Mark D, Tanay, Amos, Balicer, Ran D, Wareham, Nicholas J, Gerstung, Moritz, Dick, John E, Brennan, Paul, Vassiliou, George S, and Shlush, Liran I
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Humans ,Disease Progression ,Genetic Predisposition to Disease ,Prevalence ,Risk Assessment ,Age Factors ,Mutagenesis ,Mutation ,Models ,Genetic ,Adult ,Aged ,Middle Aged ,Health ,Female ,Male ,Leukemia ,Myeloid ,Acute ,Electronic Health Records ,Models ,Genetic ,Leukemia ,Myeloid ,Acute ,General Science & Technology - Abstract
The incidence of acute myeloid leukaemia (AML) increases with age and mortality exceeds 90% when diagnosed after age 65. Most cases arise without any detectable early symptoms and patients usually present with the acute complications of bone marrow failure1. The onset of such de novo AML cases is typically preceded by the accumulation of somatic mutations in preleukaemic haematopoietic stem and progenitor cells (HSPCs) that undergo clonal expansion2,3. However, recurrent AML mutations also accumulate in HSPCs during ageing of healthy individuals who do not develop AML, a phenomenon referred to as age-related clonal haematopoiesis (ARCH)4-8. Here we use deep sequencing to analyse genes that are recurrently mutated in AML to distinguish between individuals who have a high risk of developing AML and those with benign ARCH. We analysed peripheral blood cells from 95 individuals that were obtained on average 6.3 years before AML diagnosis (pre-AML group), together with 414 unselected age- and gender-matched individuals (control group). Pre-AML cases were distinct from controls and had more mutations per sample, higher variant allele frequencies, indicating greater clonal expansion, and showed enrichment of mutations in specific genes. Genetic parameters were used to derive a model that accurately predicted AML-free survival; this model was validated in an independent cohort of 29 pre-AML cases and 262 controls. Because AML is rare, we also developed an AML predictive model using a large electronic health record database that identified individuals at greater risk. Collectively our findings provide proof-of-concept that it is possible to discriminate ARCH from pre-AML many years before malignant transformation. This could in future enable earlier detection and monitoring, and may help to inform intervention.
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- 2018
8. Pan-cancer analysis of pre-diagnostic blood metabolite concentrations in the European Prospective Investigation into Cancer and Nutrition
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Breeur, Marie, Ferrari, Pietro, Dossus, Laure, Jenab, Mazda, Johansson, Mattias, Rinaldi, Sabina, Travis, Ruth C., His, Mathilde, Key, Tim J., Schmidt, Julie A., Overvad, Kim, Tjønneland, Anne, Kyrø, Cecilie, Rothwell, Joseph A., Laouali, Nasser, Severi, Gianluca, Kaaks, Rudolf, Katzke, Verena, Schulze, Matthias B., Eichelmann, Fabian, Palli, Domenico, Grioni, Sara, Panico, Salvatore, Tumino, Rosario, Sacerdote, Carlotta, Bueno-de-Mesquita, Bas, Olsen, Karina Standahl, Sandanger, Torkjel Manning, Nøst, Therese Haugdahl, Quirós, J. Ramón, Bonet, Catalina, Barranco, Miguel Rodríguez, Chirlaque, María-Dolores, Ardanaz, Eva, Sandsveden, Malte, Manjer, Jonas, Vidman, Linda, Rentoft, Matilda, Muller, David, Tsilidis, Kostas, Heath, Alicia K., Keun, Hector, Adamski, Jerzy, Keski-Rahkonen, Pekka, Scalbert, Augustin, Gunter, Marc J., and Viallon, Vivian
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- 2022
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9. On the use of the healthy lifestyle index to investigate specific disease outcomes
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Epi Kanker Team B, Cancer, Cardiometabolic Health, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Viallon, Vivian, Freisling, Heinz, Matta, Komodo, Nannsen, Anne Østergaard, Dahm, Christina C., Tjønneland, Anne, Eriksen, Anne Kirstine, Kaaks, Rudolf, Katzke, Verena A., Schulze, Matthias B., Masala, Giovanna, Tagliabue, Giovanna, Simeon, Vittorio, Tumino, Rosario, Milani, Lorenzo, Derksen, Jeroen W.G., van der Schouw, Yvonne T., Nøst, Therese Haugdahl, Borch, Kristin Benjaminsen, Sandanger, Torkjel M., Quirós, J. Ramón, Rodriguez-Barranco, Miguel, Bonet, Catalina, Aizpurua-Atxega, Amaia, Cirera, Lluís, Guevara, Marcela, Sundström, Björn, Winkvist, Anna, Heath, Alicia K., Gunter, Marc J., Weiderpass, Elisabete, Johansson, Mattias, Ferrari, Pietro, Epi Kanker Team B, Cancer, Cardiometabolic Health, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Viallon, Vivian, Freisling, Heinz, Matta, Komodo, Nannsen, Anne Østergaard, Dahm, Christina C., Tjønneland, Anne, Eriksen, Anne Kirstine, Kaaks, Rudolf, Katzke, Verena A., Schulze, Matthias B., Masala, Giovanna, Tagliabue, Giovanna, Simeon, Vittorio, Tumino, Rosario, Milani, Lorenzo, Derksen, Jeroen W.G., van der Schouw, Yvonne T., Nøst, Therese Haugdahl, Borch, Kristin Benjaminsen, Sandanger, Torkjel M., Quirós, J. Ramón, Rodriguez-Barranco, Miguel, Bonet, Catalina, Aizpurua-Atxega, Amaia, Cirera, Lluís, Guevara, Marcela, Sundström, Björn, Winkvist, Anna, Heath, Alicia K., Gunter, Marc J., Weiderpass, Elisabete, Johansson, Mattias, and Ferrari, Pietro
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- 2024
10. Healthy lifestyle change and all-cause and cancer mortality in the European Prospective Investigation into Cancer and Nutrition cohort
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Cancer, Matta, Komodo, Viallon, Vivian, Botteri, Edoardo, Peveri, Giulia, Dahm, Christina, Nannsen, Anne Østergaard, Olsen, Anja, Tjønneland, Anne, Elbaz, Alexis, Artaud, Fanny, Marques, Chloé, Kaaks, Rudolf, Katzke, Verena, Schulze, Matthias B., Llanaj, Erand, Masala, Giovanna, Pala, Valeria, Panico, Salvatore, Tumino, Rosario, Ricceri, Fulvio, Derksen, Jeroen W.G., Nøst, Therese Haugdahl, Sandanger, Torkjel M., Borch, Kristin Benjaminsen, Quirós, J. Ramón, Castro-Espin, Carlota, Sánchez, Maria José, Atxega, Amaia Aizpurua, Cirera, Lluís, Guevara, Marcela, Manjer, Jonas, Tin Tin, Sandar, Heath, Alicia, Touvier, Mathilde, Goldberg, Marcel, Weiderpass, Elisabete, Gunter, Marc J., Freisling, Heinz, Riboli, Elio, Ferrari, Pietro, Cancer, Matta, Komodo, Viallon, Vivian, Botteri, Edoardo, Peveri, Giulia, Dahm, Christina, Nannsen, Anne Østergaard, Olsen, Anja, Tjønneland, Anne, Elbaz, Alexis, Artaud, Fanny, Marques, Chloé, Kaaks, Rudolf, Katzke, Verena, Schulze, Matthias B., Llanaj, Erand, Masala, Giovanna, Pala, Valeria, Panico, Salvatore, Tumino, Rosario, Ricceri, Fulvio, Derksen, Jeroen W.G., Nøst, Therese Haugdahl, Sandanger, Torkjel M., Borch, Kristin Benjaminsen, Quirós, J. Ramón, Castro-Espin, Carlota, Sánchez, Maria José, Atxega, Amaia Aizpurua, Cirera, Lluís, Guevara, Marcela, Manjer, Jonas, Tin Tin, Sandar, Heath, Alicia, Touvier, Mathilde, Goldberg, Marcel, Weiderpass, Elisabete, Gunter, Marc J., Freisling, Heinz, Riboli, Elio, and Ferrari, Pietro
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- 2024
11. Prevalent diabetes and risk of total, colorectal, prostate and breast cancers in an ageing population: meta-analysis of individual participant data from cohorts of the CHANCES consortium
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Amadou, Amina, Freisling, Heinz, Jenab, Mazda, Tsilidis, Konstantinos K., Trichopoulou, Antonia, Boffetta, Paolo, Van Guelpen, Bethany, Mokoroa, Olatz, Wilsgaard, Tom, Kee, Frank, Schöttker, Ben, Ordóñez-Mena, José M., Männistö, Satu, Söderberg, Stefan, Vermeulen, Roel C. H., Quirós, J. Ramón, Liao, Linda M., Sinha, Rashmi, Kuulasmaa, Kari, Brenner, Hermann, and Romieu, Isabelle
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- 2021
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12. Cellular immune activity biomarker neopterin is associated hyperlipidemia: results from a large population-based study
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Chuang, Shu-Chun, Boeing, Heiner, Vollset, Stein Emil, Midttun, Øivind, Ueland, Per Magne, Bueno-de-Mesquita, Bas, Lajous, Martin, Fagherazzi, Guy, Boutron-Ruault, Marie-Christine, Kaaks, Rudolf, Küehn, Tilman, Pischon, Tobias, Drogan, Dagmar, Tjønneland, Anne, Overvad, Kim, Quirós, J Ramón, Agudo, Antonio, Molina-Montes, Esther, Dorronsoro, Miren, Huerta, José María, Barricarte, Aurelio, Khaw, Kay-Tee, Wareham, Nicholas J, Travis, Ruth C, Trichopoulou, Antonia, Lagiou, Pagona, Trichopoulos, Dimitrios, Masala, Giovanna, Agnoli, Claudia, Tumino, Rosario, Mattiello, Amalia, Peeters, Petra H, Weiderpass, Elisabete, Palmqvist, Richard, Ljuslinder, Ingrid, Gunter, Marc, Lu, Yunxia, Cross, Amanda J, Riboli, Elio, Vineis, Paolo, and Aleksandrova, Krasimira
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Biomedical and Clinical Sciences ,Nutrition and Dietetics ,Cardiovascular ,Nutrition ,Aging ,Clinical Research ,Cell-mediated immunity ,Metabolic syndrome ,Neopterin ,Clinical Sciences ,Immunology ,Clinical sciences - Abstract
BackgroundIncreased serum neopterin had been described in older age two decades ago. Neopterin is a biomarker of systemic adaptive immune activation that could be potentially implicated in metabolic syndrome (MetS). Measurements of waist circumference, triglycerides, high-density lipoprotein cholesterol (HDLC), systolic and diastolic blood pressure, glycated hemoglobin as components of MetS definition, and plasma total neopterin concentrations were performed in 594 participants recruited in the European Prospective Investigation into Cancer and Nutrition (EPIC).ResultsHigher total neopterin concentrations were associated with reduced HDLC (9.7 %, p
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- 2016
13. Main nutrient patterns are associated with prospective weight change in adults from 10 European countries
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Freisling, Heinz, Pisa, Pedro T, Ferrari, Pietro, Byrnes, Graham, Moskal, Aurelie, Dahm, Christina C, Vergnaud, Anne-Claire, Boutron-Ruault, Marie-Christine, Fagherazzi, Guy, Cadeau, Claire, Kühn, Tilman, Neamat-Allah, Jasmine, Buijsse, Brian, Boeing, Heiner, Halkjær, Jytte, Tjonneland, Anne, Hansen, Camilla P, Quirós, J Ramón, Travier, Noémie, Molina-Montes, Esther, Amiano, Pilar, Huerta, José M, Barricarte, Aurelio, Khaw, Kay-Tee, Wareham, Nicholas, Key, Tim J, Romaguera, Dora, Lu, Yunxia, Lassale, Camille M, Naska, Androniki, Orfanos, Philippos, Trichopoulou, Antonia, Masala, Giovanna, Pala, Valeria, Berrino, Franco, Tumino, Rosario, Ricceri, Fulvio, de Magistris, Maria Santucci, Bueno-de-Mesquita, H Bas, Ocké, Marga C, Sonestedt, Emily, Ericson, Ulrika, Johansson, Mattias, Skeie, Guri, Weiderpass, Elisabete, Braaten, Tonje, Peeters, Petra HM, and Slimani, Nadia
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Public Health ,Biomedical and Clinical Sciences ,Nutrition and Dietetics ,Health Sciences ,Clinical Research ,Prevention ,Nutrition ,Metabolic and endocrine ,Adult ,Aged ,Ascorbic Acid ,Calcium ,Dietary ,Diet ,Dietary Fiber ,Dietary Proteins ,Europe ,Female ,Folic Acid ,Follow-Up Studies ,Humans ,Linear Models ,Male ,Middle Aged ,Nutrition Assessment ,Phosphorus ,Dietary ,Prospective Studies ,Riboflavin ,Surveys and Questionnaires ,Weight Gain ,beta Carotene ,Dietary patterns ,Energy balance ,Nutrients ,Obesity ,Public health ,Weight gain ,Nutrition & Dietetics ,Nutrition and dietetics ,Epidemiology - Abstract
PurposeVarious food patterns have been associated with weight change in adults, but it is unknown which combinations of nutrients may account for such observations. We investigated associations between main nutrient patterns and prospective weight change in adults.MethodsThis study includes 235,880 participants, 25-70 years old, recruited between 1992 and 2000 in 10 European countries. Intakes of 23 nutrients were estimated from country-specific validated dietary questionnaires using the harmonized EPIC Nutrient DataBase. Four nutrient patterns, explaining 67 % of the total variance of nutrient intakes, were previously identified from principal component analysis. Body weight was measured at recruitment and self-reported 5 years later. The relationship between nutrient patterns and annual weight change was examined separately for men and women using linear mixed models with random effect according to center controlling for confounders.ResultsMean weight gain was 460 g/year (SD 950) and 420 g/year (SD 940) for men and women, respectively. The annual differences in weight gain per one SD increase in the pattern scores were as follows: principal component (PC) 1, characterized by nutrients from plant food sources, was inversely associated with weight gain in men (-22 g/year; 95 % CI -33 to -10) and women (-18 g/year; 95 % CI -26 to -11). In contrast, PC4, characterized by protein, vitamin B2, phosphorus, and calcium, was associated with a weight gain of +41 g/year (95 % CI +2 to +80) and +88 g/year (95 % CI +36 to +140) in men and women, respectively. Associations with PC2, a pattern driven by many micro-nutrients, and with PC3, a pattern driven by vitamin D, were less consistent and/or non-significant.ConclusionsWe identified two main nutrient patterns that are associated with moderate but significant long-term differences in weight gain in adults.
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- 2016
14. A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease
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Scott, Robert A, Freitag, Daniel F, Li, Li, Chu, Audrey Y, Surendran, Praveen, Young, Robin, Grarup, Niels, Stancáková, Alena, Chen, Yuning, Varga, Tibor V, Yaghootkar, Hanieh, Luan, Jian’an, Zhao, Jing Hua, Willems, Sara M, Wessel, Jennifer, Wang, Shuai, Maruthur, Nisa, Michailidou, Kyriaki, Pirie, Ailith, van der Lee, Sven J, Gillson, Christopher, Al Olama, Ali Amin, Amouyel, Philippe, Arriola, Larraitz, Arveiler, Dominique, Aviles-Olmos, Iciar, Balkau, Beverley, Barricarte, Aurelio, Barroso, Inês, Garcia, Sara Benlloch, Bis, Joshua C, Blankenberg, Stefan, Boehnke, Michael, Boeing, Heiner, Boerwinkle, Eric, Borecki, Ingrid B, Bork-Jensen, Jette, Bowden, Sarah, Caldas, Carlos, Caslake, Muriel, consortium, The CVD50, Cupples, L Adrienne, Cruchaga, Carlos, Czajkowski, Jacek, Hoed, Marcel den, Dunn, Janet A, Earl, Helena M, Ehret, Georg B, Ferrannini, Ele, Ferrieres, Jean, Foltynie, Thomas, Ford, Ian, Forouhi, Nita G, Gianfagna, Francesco, Gonzalez, Carlos, Grioni, Sara, Hiller, Louise, Jansson, Jan-Håkan, Jørgensen, Marit E, Jukema, J Wouter, Kaaks, Rudolf, Kee, Frank, Kerrison, Nicola D, Key, Timothy J, Kontto, Jukka, Kote-Jarai, Zsofia, Kraja, Aldi T, Kuulasmaa, Kari, Kuusisto, Johanna, Linneberg, Allan, Liu, Chunyu, Marenne, Gaëlle, Mohlke, Karen L, Morris, Andrew P, Muir, Kenneth, Müller-Nurasyid, Martina, Munroe, Patricia B, Navarro, Carmen, Nielsen, Sune F, Nilsson, Peter M, Nordestgaard, Børge G, Packard, Chris J, Palli, Domenico, Panico, Salvatore, Peloso, Gina M, Perola, Markus, Peters, Annette, Poole, Christopher J, Quirós, J Ramón, Rolandsson, Olov, Sacerdote, Carlotta, Salomaa, Veikko, Sánchez, María-José, Sattar, Naveed, Sharp, Stephen J, Sims, Rebecca, Slimani, Nadia, Smith, Jennifer A, Thompson, Deborah J, and Trompet, Stella
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Pharmacology and Pharmaceutical Sciences ,Biomedical and Clinical Sciences ,Clinical Research ,Diabetes ,Human Genome ,Cardiovascular ,Prevention ,Obesity ,Genetics ,Heart Disease ,Heart Disease - Coronary Heart Disease ,Clinical Trials and Supportive Activities ,Aetiology ,Development of treatments and therapeutic interventions ,5.1 Pharmaceuticals ,2.1 Biological and endogenous factors ,Metabolic and endocrine ,Good Health and Well Being ,Alleles ,Coronary Disease ,Diabetes Mellitus ,Type 2 ,Dipeptidyl Peptidase 4 ,Genotype ,Glucagon-Like Peptide-1 Receptor ,Humans ,Receptor ,Cannabinoid ,CB2 ,Receptor ,Serotonin ,5-HT2C ,Receptors ,Somatostatin ,Sodium-Glucose Transporter 1 ,CVD50 consortium ,GERAD_EC Consortium ,Neurology Working Group of the Cohorts for Heart ,Aging Research in Genomic Epidemiology ,Alzheimer’s Disease Genetics Consortium ,Pancreatic Cancer Cohort Consortium ,European Prospective Investigation into Cancer and Nutrition–Cardiovascular Disease ,EPIC-InterAct ,CHARGE consortium ,CHD Exome+ Consortium ,CARDIOGRAM Exome Consortium ,Biological Sciences ,Medical and Health Sciences ,Medical biotechnology ,Biomedical engineering - Abstract
Regulatory authorities have indicated that new drugs to treat type 2 diabetes (T2D) should not be associated with an unacceptable increase in cardiovascular risk. Human genetics may be able to guide development of antidiabetic therapies by predicting cardiovascular and other health endpoints. We therefore investigated the association of variants in six genes that encode drug targets for obesity or T2D with a range of metabolic traits in up to 11,806 individuals by targeted exome sequencing and follow-up in 39,979 individuals by targeted genotyping, with additional in silico follow-up in consortia. We used these data to first compare associations of variants in genes encoding drug targets with the effects of pharmacological manipulation of those targets in clinical trials. We then tested the association of those variants with disease outcomes, including coronary heart disease, to predict cardiovascular safety of these agents. A low-frequency missense variant (Ala316Thr; rs10305492) in the gene encoding glucagon-like peptide-1 receptor (GLP1R), the target of GLP1R agonists, was associated with lower fasting glucose and T2D risk, consistent with GLP1R agonist therapies. The minor allele was also associated with protection against heart disease, thus providing evidence that GLP1R agonists are not likely to be associated with an unacceptable increase in cardiovascular risk. Our results provide an encouraging signal that these agents may be associated with benefit, a question currently being addressed in randomized controlled trials. Genetic variants associated with metabolic traits and multiple disease outcomes can be used to validate therapeutic targets at an early stage in the drug development process.
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- 2016
15. Fine mapping of chromosome 5p15.33 based on a targeted deep sequencing and high density genotyping identifies novel lung cancer susceptibility loci
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Kachuri, Linda, Amos, Christopher I, McKay, James D, Johansson, Mattias, Vineis, Paolo, Bueno-de-Mesquita, H Bas, Boutron-Ruault, Marie-Christine, Johansson, Mikael, Quirós, J Ramón, Sieri, Sabina, Travis, Ruth C, Weiderpass, Elisabete, Le Marchand, Loic, Henderson, Brian E, Wilkens, Lynne, Goodman, Gary E, Chen, Chu, Doherty, Jennifer A, Christiani, David C, Wei, Yongyue, Su, Li, Tworoger, Shelley, Zhang, Xuehong, Kraft, Peter, Zaridze, David, Field, John K, Marcus, Michael W, Davies, Michael PA, Hyde, Russell, Caporaso, Neil E, Landi, Maria Teresa, Severi, Gianluca, Giles, Graham G, Liu, Geoffrey, McLaughlin, John R, Li, Yafang, Xiao, Xiangjun, Fehringer, Gord, Zong, Xuchen, Denroche, Robert E, Zuzarte, Philip C, McPherson, John D, Brennan, Paul, and Hung, Rayjean J
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Lung ,Human Genome ,Genetics ,Cancer ,Prevention ,Lung Cancer ,2.1 Biological and endogenous factors ,Aetiology ,Case-Control Studies ,Chromosome Mapping ,Chromosomes ,Human ,Pair 5 ,Female ,Genetic Loci ,Genetic Predisposition to Disease ,Genotyping Techniques ,Humans ,Lung Neoplasms ,Male ,Middle Aged ,Oncology and Carcinogenesis ,Oncology & Carcinogenesis - Abstract
Chromosome 5p15.33 has been identified as a lung cancer susceptibility locus, however the underlying causal mechanisms were not fully elucidated. Previous fine-mapping studies of this locus have relied on imputation or investigated a small number of known, common variants. This study represents a significant advance over previous research by investigating a large number of novel, rare variants, as well as their underlying mechanisms through telomere length. Variants for this fine-mapping study were identified through a targeted deep sequencing (average depth of coverage greater than 4000×) of 576 individuals. Subsequently, 4652 SNPs, including 1108 novel SNPs, were genotyped in 5164 cases and 5716 controls of European ancestry. After adjusting for known risk loci, rs2736100 and rs401681, we identified a new, independent lung cancer susceptibility variant in LPCAT1: rs139852726 (OR = 0.46, P = 4.73×10(-9)), and three new adenocarcinoma risk variants in TERT: rs61748181 (OR = 0.53, P = 2.64×10(-6)), rs112290073 (OR = 1.85, P = 1.27×10(-5)), rs138895564 (OR = 2.16, P = 2.06×10(-5); among young cases, OR = 3.77, P = 8.41×10(-4)). In addition, we found that rs139852726 (P = 1.44×10(-3)) was associated with telomere length in a sample of 922 healthy individuals. The gene-based SKAT-O analysis implicated TERT as the most relevant gene in the 5p15.33 region for adenocarcinoma (P = 7.84×10(-7)) and lung cancer (P = 2.37×10(-5)) risk. In this largest fine-mapping study to investigate a large number of rare and novel variants within 5p15.33, we identified novel lung and adenocarcinoma susceptibility loci with large effects and provided support for the role of telomere length as the potential underlying mechanism.
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- 2016
16. Dietary fat, fat subtypes and hepatocellular carcinoma in a large European cohort
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Duarte-Salles, Talita, Fedirko, Veronika, Stepien, Magdalena, Aleksandrova, Krasimira, Bamia, Christina, Lagiou, Pagona, Laursen, Anne Sofie Dam, Hansen, Louise, Overvad, Kim, Tjønneland, Anne, Boutron-Ruault, Marie-Christine, Fagherazzi, Guy, His, Mathilde, Boeing, Heiner, Katzke, Verena, Kühn, Tilman, Trichopoulou, Antonia, Valanou, Elissavet, Kritikou, Maria, Masala, Giovanna, Panico, Salvatore, Sieri, Sabina, Ricceri, Fulvio, Tumino, Rosario, Bueno-de-Mesquita, HB As, Peeters, Petra H, Hjartåker, Anette, Skeie, Guri, Weiderpass, Elisabete, Ardanaz, Eva, Bonet, Catalina, Chirlaque, Maria-Dolores, Dorronsoro, Miren, Quirós, J Ramón, Johansson, Ingegerd, Ohlsson, Bodil, Sjöberg, Klas, Wennberg, Maria, Khaw, Kay-Tee, Travis, Ruth C, Wareham, Nick, Ferrari, Pietro, Freisling, Heinz, Romieu, Isabelle, Cross, Amanda J, Gunter, Marc, Lu, Yunxia, and Jenab, Mazda
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Biomedical and Clinical Sciences ,Nutrition and Dietetics ,Hepatitis ,Infectious Diseases ,Hepatitis - B ,Liver Cancer ,Prevention ,Liver Disease ,Cancer ,Chronic Liver Disease and Cirrhosis ,Rare Diseases ,Nutrition ,Digestive Diseases ,Clinical Research ,Emerging Infectious Diseases ,Detection ,screening and diagnosis ,4.1 Discovery and preclinical testing of markers and technologies ,Good Health and Well Being ,Adult ,Aged ,Carcinoma ,Hepatocellular ,Case-Control Studies ,Diet ,Dietary Fats ,Europe ,Feeding Behavior ,Female ,Humans ,Incidence ,Life Style ,Liver Neoplasms ,Male ,Middle Aged ,Nutritional Status ,Prospective Studies ,Risk ,Risk Factors ,Surveys and Questionnaires ,Young Adult ,European populations ,cohort study ,dietary fats ,hepatocellular carcinoma ,Oncology and Carcinogenesis ,Oncology & Carcinogenesis ,Oncology and carcinogenesis - Abstract
The role of amount and type of dietary fat consumption in the etiology of hepatocellular carcinoma (HCC) is poorly understood, despite suggestive biological plausibility. The associations of total fat, fat subtypes and fat sources with HCC incidence were investigated in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, which includes 191 incident HCC cases diagnosed between 1992 and 2010. Diet was assessed by country-specific, validated dietary questionnaires. A single 24-hr diet recall from a cohort subsample was used for measurement error calibration. Hazard ratios (HR) and 95% confidence intervals (95% CI) were estimated from Cox proportional hazard models. Hepatitis B and C viruses (HBV/HCV) status and biomarkers of liver function were assessed separately in a nested case-control subset with available blood samples (HCC = 122). In multivariable calibrated models, there was a statistically significant inverse association between total fat intake and risk of HCC (per 10 g/day, HR = 0.80, 95% CI: 0.65-0.99), which was mainly driven by monounsaturated fats (per 5 g/day, HR = 0.71, 95% CI: 0.55-0.92) rather than polyunsaturated fats (per 5 g/day, HR = 0.92, 95% CI: 0.68-1.25). There was no association between saturated fats (HR = 1.08, 95% CI: 0.88-1.34) and HCC risk. The ratio of polyunsaturated/monounsaturated fats to saturated fats was not significantly associated with HCC risk (per 0.2 point, HR = 0.86, 95% CI: 0.73-1.01). Restriction of analyses to HBV/HCV free participants or adjustment for liver function did not substantially alter the findings. In this large prospective European cohort, higher consumption of monounsaturated fats is associated with lower HCC risk.
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- 2015
17. General and abdominal obesity and risk of esophageal and gastric adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition
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Steffen, Annika, Huerta, José-Maria, Weiderpass, Elisabete, Bueno-de-Mesquita, HB As, May, Anne M, Siersema, Peter D, Kaaks, Rudolf, Neamat-Allah, Jasmine, Pala, Valeria, Panico, Salvatore, Saieva, Calogero, Tumino, Rosario, Naccarati, Alessio, Dorronsoro, Miren, Sánchez-Cantalejo, Emilio, Ardanaz, Eva, Quirós, J Ramón, Ohlsson, Bodil, Johansson, Mattias, Wallner, Bengt, Overvad, Kim, Halkjaer, Jytte, Tjønneland, Anne, Fagherazzi, Guy, Racine, Antoine, Clavel-Chapelon, Françoise, Key, Tim J, Khaw, Kay-Tee, Wareham, Nick, Lagiou, Pagona, Bamia, Christina, Trichopoulou, Antonia, Ferrari, Pietro, Freisling, Heinz, Lu, Yunxia, Riboli, Elio, Cross, Amanda J, Gonzalez, Carlos A, and Boeing, Heiner
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Biomedical and Clinical Sciences ,Nutrition and Dietetics ,Prevention ,Rare Diseases ,Digestive Diseases ,Cancer ,Obesity ,Nutrition ,Adenocarcinoma ,Adult ,Aged ,Body Mass Index ,Body Weights and Measures ,Esophageal Neoplasms ,Europe ,Female ,Follow-Up Studies ,Humans ,Male ,Middle Aged ,Obesity ,Abdominal ,Population Surveillance ,Prospective Studies ,Risk ,Risk Factors ,Stomach Neoplasms ,abdominal obesity ,body mass index ,esophageal cancer ,gastric cancer ,general obesity ,waist circumference ,Oncology and Carcinogenesis ,Oncology & Carcinogenesis ,Oncology and carcinogenesis - Abstract
General obesity, as reflected by BMI, is an established risk factor for esophageal adenocarcinoma (EAC), a suspected risk factor for gastric cardia adenocarcinoma (GCC) and appears unrelated to gastric non-cardia adenocarcinoma (GNCC). How abdominal obesity, as commonly measured by waist circumference (WC), relates to these cancers remains largely unexplored. Using measured anthropometric data from 391,456 individuals from the European Prospective Investigation into Cancer and Nutrition (EPIC) study and 11 years of follow-up, we comprehensively assessed the association of anthropometric measures with risk of EAC, GCC and GNCC using multivariable proportional hazards regression. One hundred twenty-four incident EAC, 193 GCC and 224 GNCC were accrued. After mutual adjustment, BMI was unrelated to EAC, while WC showed a strong positive association (highest vs. lowest quintile HR = 1.19; 95% CI, 0.63-2.22 and HR = 3.76; 1.72-8.22, respectively). Hip circumference (HC) was inversely related to EAC after controlling for WC, while WC remained positively associated (HR = 0.35; 0.18-0.68, and HR=4.10; 1.94-8.63, respectively). BMI was not associated with GCC or GNCC. WC was related to higher risks of GCC after adjustment for BMI and more strongly after adjustment for HC (highest vs. lowest quintile HR = 1.91; 1.09-3.37, and HR = 2.23; 1.28-3.90, respectively). Our study demonstrates that abdominal, rather than general, obesity is an indisputable risk factor for EAC and also provides evidence for a protective effect of gluteofemoral (subcutaneous) adipose tissue in EAC. Our study further shows that general obesity is not a risk factor for GCC and GNCC, while the role of abdominal obesity in GCC needs further investigation.
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- 2015
18. A Prospective Study of the Immune System Activation Biomarker Neopterin and Colorectal Cancer Risk
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Aleksandrova, Krasimira, Chuang, Shu-Chun, Boeing, Heiner, Zuo, Hui, Tell, Grethe S, Pischon, Tobias, Jenab, Mazda, Bueno-de-Mesquita, Bas, Vollset, Stein Emil, Midttun, Øivind, Ueland, Per Magne, Fedirko, Veronika, Johansson, Mattias, Weiderpass, Elisabete, Severi, Gianluca, Racine, Antoine, Boutron-Ruault, Marie-Christine, Kaaks, Rudolf, Kühn, Tilman, Tjønneland, Anne, Overvad, Kim, Quirós, J Ramón, Jakszyn, Paula, Sánchez, María-José, Dorronsoro, Miren, Chirlaque, Maria-Dolores, Ardanaz, Eva, Khaw, Kay-Tee, Wareham, Nicholas J, Travis, Ruth C, Trichopoulou, Antonia, Lagiou, Pagona, Trichopoulos, Dimitrios, Palli, Domenico, Sieri, Sabina, Tumino, Rosario, Panico, Salvatore, May, Anne M, Palmqvist, Richard, Ljuslinder, Ingrid, Kong, So Yeon J, Freisling, Heinz, Gunter, Marc J, Lu, Yunxia, Cross, Amanda J, Riboli, Elio, and Vineis, Paolo
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Biomedical and Clinical Sciences ,Oncology and Carcinogenesis ,Colo-Rectal Cancer ,Cancer ,Clinical Research ,Digestive Diseases ,Adult ,Aged ,Biomarkers ,Tumor ,Case-Control Studies ,Chromatography ,Liquid ,Colonic Neoplasms ,Colorectal Neoplasms ,Europe ,Female ,Humans ,Immunity ,Cellular ,Male ,Middle Aged ,Neopterin ,Odds Ratio ,Prospective Studies ,Rectal Neoplasms ,Sensitivity and Specificity ,T-Lymphocytes ,Helper-Inducer ,Tandem Mass Spectrometry ,Oncology & Carcinogenesis ,Oncology and carcinogenesis - Abstract
Neopterin may be relevant for colorectal cancer (CRC) development, as a biomarker of cellular immune activity exerting pleiotropic effects on cellular ageing, oxidative stress, and inflammation. So far, the association between prediagnostic neopterin and colon and rectal cancer risk has not been evaluated in human populations. A nested case-control study was conducted within the European Prospective Investigation into Cancer and Nutrition cohort using data on plasma concentrations of total neopterin (T-N, sum of neopterin and 7,8-dihydroneopterin) in 830 incident CRC case patients (561 colon and 269 rectal) matched within risk sets to 830 control participants. A subsequent replication study used data from the Hordaland Health Study, where 173 CRC case patients have been diagnosed among 6594 healthy participants over 12 years of follow-up. After multivariable adjustment for a priori chosen CRC risk factors, a "U-shaped" association of T-N with CRC was revealed. Compared with the second quintile of the T-N distribution, the relative risks for the first, third, fourth, and fifth quintiles were 2.37 (95% CI = 1.66 to 3.39), 1.24 (95% CI = 0.87 to 1.77), 1.55 (95% CI = 1.08 to 2.22), and 2.31 (95% CI = 1.63 to 3.27), respectively. Replication of these associations within the Hordaland Health Study yielded similar results. No differences have been observed when the associations were explored by colon and rectal cancer site (two-sided P difference = .87) and after excluding case patients diagnosed within the first four follow-up years. These novel findings provide evidence of the role of both suppressed and activated cell-mediated immunity as reflected by prediagnostic T-N concentrations in the development of CRC.
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- 2015
19. Dietary intake of trans fatty acids and breast cancer risk in 9 European countries
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Matta, Michèle, Huybrechts, Inge, Biessy, Carine, Casagrande, Corinne, Yammine, Sahar, Fournier, Agnès, Olsen, Karina Standahl, Lukic, Marco, Gram, Inger Torhild, Ardanaz, Eva, Sánchez, Maria-José, Dossus, Laure, Fortner, Renée T., Srour, Bernard, Jannasch, Franziska, Schulze, Matthias B., Amiano, Pilar, Agudo, Antonio, Colorado-Yohar, Sandra, Quirós, J. Ramón, Tumino, Rosario, Panico, Salvatore, Masala, Giovanna, Pala, Valeria, Sacerdote, Carlotta, Tjønneland, Anne, Olsen, Anja, Dahm, Christina C., Rosendahl, Ann H., Borgquist, Signe, Wennberg, Maria, Heath, Alicia K., Aune, Dagfinn, Schmidt, Julie, Weiderpass, Elisabete, Chajes, Veronique, Gunter, Marc J., and Murphy, Neil
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- 2021
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20. Heterogeneity of Colorectal Cancer Risk Factors by Anatomical Subsite in 10 European Countries: A Multinational Cohort Study
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Murphy, Neil, Ward, Heather A., Jenab, Mazda, Rothwell, Joseph A., Boutron-Ruault, Marie-Christine, Carbonnel, Franck, Kvaskoff, Marina, Kaaks, Rudolf, Kühn, Tilman, Boeing, Heiner, Aleksandrova, Krasimira, Weiderpass, Elisabete, Skeie, Guri, Borch, Kristin Benjaminsen, Tjønneland, Anne, Kyrø, Cecilie, Overvad, Kim, Dahm, Christina C., Jakszyn, Paula, Sánchez, Maria-Jose, Gil, Leire, Huerta, José M., Barricarte, Aurelio, Quirós, J. Ramón, Khaw, Kay-Tee, Wareham, Nick, Bradbury, Kathryn E., Trichopoulou, Antonia, La Vecchia, Carlo, Karakatsani, Anna, Palli, Domenico, Grioni, Sara, Tumino, Rosario, Fasanelli, Francesca, Panico, Salvatore, Bueno-de-Mesquita, Bas, Peeters, Petra H., Gylling, Björn, Myte, Robin, Jirström, Karin, Berntsson, Jonna, Xue, Xiaonan, Riboli, Elio, Cross, Amanda J., and Gunter, Marc J.
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- 2019
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21. Interaction between genes and macronutrient intake on the risk of developing type 2 diabetes: systematic review and findings from European Prospective Investigation into Cancer (EPIC)-InterAct
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Li, Sherly X, Imamura, Fumiaki, Ye, Zheng, Schulze, Matthias B, Zheng, Jusheng, Ardanaz, Eva, Arriola, Larraitz, Boeing, Heiner, Dow, Courtney, Fagherazzi, Guy, Franks, Paul W, Agudo, Antonio, Grioni, Sara, Kaaks, Rudolf, Katzke, Verena A, Key, Timothy J, Khaw, Kay Tee, Mancini, Francesca R, Navarro, Carmen, Nilsson, Peter M, Onland-Moret, N Charlotte, Overvad, Kim, Palli, Domenico, Panico, Salvatore, Quirós, J Ramón, Rolandsson, Olov, Sacerdote, Carlotta, Sánchez, María-José, Slimani, Nadia, Sluijs, Ivonne, Spijkerman, Annemieke MW, Tjonneland, Anne, Tumino, Rosario, Sharp, Stephen J, Riboli, Elio, Langenberg, Claudia, Scott, Robert A, Forouhi, Nita G, and Wareham, Nicholas J
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- 2017
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22. DNA methylome analysis identifies accelerated epigenetic ageing associated with postmenopausal breast cancer susceptibility
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Ambatipudi, Srikant, Horvath, Steve, Perrier, Flavie, Cuenin, Cyrille, Hernandez-Vargas, Hector, Le Calvez-Kelm, Florence, Durand, Geoffroy, Byrnes, Graham, Ferrari, Pietro, Bouaoun, Liacine, Sklias, Athena, Chajes, Véronique, Overvad, Kim, Severi, Gianluca, Baglietto, Laura, Clavel-Chapelon, Françoise, Kaaks, Rudolf, Barrdahl, Myrto, Boeing, Heiner, Trichopoulou, Antonia, Lagiou, Pagona, Naska, Androniki, Masala, Giovanna, Agnoli, Claudia, Polidoro, Silvia, Tumino, Rosario, Panico, Salvatore, Dollé, Martijn, Peeters, Petra H.M., Onland-Moret, N. Charlotte, Sandanger, Torkjel M., Nøst, Therese H., Weiderpass, Elisabete, Quirós, J. Ramón, Agudo, Antonio, Rodriguez-Barranco, Miguel, Huerta Castaño, José María, Barricarte, Aurelio, Fernández, Ander Matheu, Travis, Ruth C., Vineis, Paolo, Muller, David C., Riboli, Elio, Gunter, Marc, Romieu, Isabelle, and Herceg, Zdenko
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- 2017
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23. Adiposity, metabolites, and colorectal cancer risk: Mendelian randomization study
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Bull, Caroline J., Bell, Joshua A., Murphy, Neil, Sanderson, Eleanor, Davey Smith, George, Timpson, Nicholas J., Banbury, Barbara L., Albanes, Demetrius, Berndt, Sonja I., Bézieau, Stéphane, Bishop, D. Timothy, Brenner, Hermann, Buchanan, Daniel D., Burnett-Hartman, Andrea, Casey, Graham, Castellví-Bel, Sergi, Chan, Andrew T., Chang-Claude, Jenny, Cross, Amanda J., de la Chapelle, Albert, Figueiredo, Jane C., Gallinger, Steven J., Gapstur, Susan M., Giles, Graham G., Gruber, Stephen B., Gsur, Andrea, Hampe, Jochen, Hampel, Heather, Harrison, Tabitha A., Hoffmeister, Michael, Hsu, Li, Huang, Wen-Yi, Huyghe, Jeroen R., Jenkins, Mark A., Joshu, Corinne E., Keku, Temitope O., Kühn, Tilman, Kweon, Sun-Seog, Le Marchand, Loic, Li, Christopher I., Li, Li, Lindblom, Annika, Martín, Vicente, May, Anne M., Milne, Roger L., Moreno, Victor, Newcomb, Polly A., Offit, Kenneth, Ogino, Shuji, Phipps, Amanda I., Platz, Elizabeth A., Potter, John D., Qu, Conghui, Quirós, J. Ramón, Rennert, Gad, Riboli, Elio, Sakoda, Lori C., Schafmayer, Clemens, Schoen, Robert E., Slattery, Martha L., Tangen, Catherine M., Tsilidis, Kostas K., Ulrich, Cornelia M., van Duijnhoven, Fränzel J. B., van Guelpen, Bethany, Visvanathan, Kala, Vodicka, Pavel, Vodickova, Ludmila, Wang, Hansong, White, Emily, Wolk, Alicja, Woods, Michael O., Wu, Anna H., Campbell, Peter T., Zheng, Wei, Peters, Ulrike, Vincent, Emma E., and Gunter, Marc J.
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- 2020
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24. A Body Shape Index (ABSI) achieves better mortality risk stratification than alternative indices of abdominal obesity: results from a large European cohort
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Christakoudi, Sofia, Tsilidis, Konstantinos K., Muller, David C., Freisling, Heinz, Weiderpass, Elisabete, Overvad, Kim, Söderberg, Stefan, Häggström, Christel, Pischon, Tobias, Dahm, Christina C., Zhang, Jie, Tjønneland, Anne, Halkjær, Jytte, MacDonald, Conor, Boutron-Ruault, Marie-Christine, Mancini, Francesca Romana, Kühn, Tilman, Kaaks, Rudolf, Schulze, Matthias B., Trichopoulou, Antonia, Karakatsani, Anna, Peppa, Eleni, Masala, Giovanna, Pala, Valeria, Panico, Salvatore, Tumino, Rosario, Sacerdote, Carlotta, Quirós, J. Ramón, Agudo, Antonio, Sánchez, Maria-Jose, Cirera, Lluís, Barricarte-Gurrea, Aurelio, Amiano, Pilar, Memarian, Ensieh, Sonestedt, Emily, Bueno-de-Mesquita, Bas, May, Anne M., Khaw, Kay-Tee, Wareham, Nicholas J., Tong, Tammy Y. N., Huybrechts, Inge, Noh, Hwayoung, Aglago, Elom K., Ellingjord-Dale, Merete, Ward, Heather A., Aune, Dagfinn, and Riboli, Elio
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- 2020
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25. Interplay between genetic predisposition, macronutrient intake and type 2 diabetes incidence: analysis within EPIC-InterAct across eight European countries
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Li, Sherly X., Imamura, Fumiaki, Schulze, Matthias B., Zheng, Jusheng, Ye, Zheng, Agudo, Antonio, Ardanaz, Eva, Aune, Dagfinn, Boeing, Heiner, Dorronsoro, Miren, Dow, Courtney, Fagherazzi, Guy, Grioni, Sara, Gunter, Marc J., Huerta, José María, Ibsen, Daniel B., Jakobsen, Marianne Uhre, Kaaks, Rudolf, Key, Timothy J., Khaw, Kay-Tee, Kyrø, Cecilie, Mancini, Francesca Romana, Molina-Portillo, Elena, Murphy, Neil, Nilsson, Peter M., Onland-Moret, N. Charlotte, Palli, Domenico, Panico, Salvatore, Poveda, Alaitz, Quirós, J. Ramón, Ricceri, Fulvio, Sluijs, Ivonne, Spijkerman, Annemieke M. W., Tjonneland, Anne, Tumino, Rosario, Winkvist, Anna, Langenberg, Claudia, Sharp, Stephen J., Riboli, Elio, Scott, Robert A., Forouhi, Nita G., and Wareham, Nicholas J.
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- 2018
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26. Plasma levels of OPN (ng/ml) in HCC Cases and matched Controls. from Circulating Osteopontin and Prediction of Hepatocellular Carcinoma Development in a Large European Population
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Duarte-Salles, Talita, primary, Misra, Sandeep, primary, Stepien, Magdalena, primary, Plymoth, Amelie, primary, Muller, David, primary, Overvad, Kim, primary, Olsen, Anja, primary, Tjønneland, Anne, primary, Baglietto, Laura, primary, Severi, Gianluca, primary, Boutron-Ruault, Marie-Christine, primary, Turzanski-Fortner, Renee, primary, Kaaks, Rudolf, primary, Boeing, Heiner, primary, Aleksandrova, Krasimira, primary, Trichopoulou, Antonia, primary, Lagiou, Pagona, primary, Bamia, Christina, primary, Pala, Valeria, primary, Palli, Domenico, primary, Mattiello, Amalia, primary, Tumino, Rosario, primary, Naccarati, Alessio, primary, Bueno-de-Mesquita, H.B(as)., primary, Peeters, Petra H., primary, Weiderpass, Elisabete, primary, Quirós, J. Ramón, primary, Agudo, Antonio, primary, Sánchez-Cantalejo, Emilio, primary, Ardanaz, Eva, primary, Gavrila, Diana, primary, Dorronsoro, Miren, primary, Werner, Mårten, primary, Hemmingsson, Oskar, primary, Ohlsson, Bodil, primary, Sjöberg, Klas, primary, Wareham, Nicholas J., primary, Khaw, Kay-Tee, primary, Bradbury, Kathryn E., primary, Gunter, Marc J., primary, Cross, Amanda J., primary, Riboli, Elio, primary, Jenab, Mazda, primary, Hainaut, Pierre, primary, and Beretta, Laura, primary
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- 2023
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27. Data from Circulating Osteopontin and Prediction of Hepatocellular Carcinoma Development in a Large European Population
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Duarte-Salles, Talita, primary, Misra, Sandeep, primary, Stepien, Magdalena, primary, Plymoth, Amelie, primary, Muller, David, primary, Overvad, Kim, primary, Olsen, Anja, primary, Tjønneland, Anne, primary, Baglietto, Laura, primary, Severi, Gianluca, primary, Boutron-Ruault, Marie-Christine, primary, Turzanski-Fortner, Renee, primary, Kaaks, Rudolf, primary, Boeing, Heiner, primary, Aleksandrova, Krasimira, primary, Trichopoulou, Antonia, primary, Lagiou, Pagona, primary, Bamia, Christina, primary, Pala, Valeria, primary, Palli, Domenico, primary, Mattiello, Amalia, primary, Tumino, Rosario, primary, Naccarati, Alessio, primary, Bueno-de-Mesquita, H.B(as)., primary, Peeters, Petra H., primary, Weiderpass, Elisabete, primary, Quirós, J. Ramón, primary, Agudo, Antonio, primary, Sánchez-Cantalejo, Emilio, primary, Ardanaz, Eva, primary, Gavrila, Diana, primary, Dorronsoro, Miren, primary, Werner, Mårten, primary, Hemmingsson, Oskar, primary, Ohlsson, Bodil, primary, Sjöberg, Klas, primary, Wareham, Nicholas J., primary, Khaw, Kay-Tee, primary, Bradbury, Kathryn E., primary, Gunter, Marc J., primary, Cross, Amanda J., primary, Riboli, Elio, primary, Jenab, Mazda, primary, Hainaut, Pierre, primary, and Beretta, Laura, primary
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- 2023
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28. Supplementary Figures Legends from Circulating Osteopontin and Prediction of Hepatocellular Carcinoma Development in a Large European Population
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Duarte-Salles, Talita, primary, Misra, Sandeep, primary, Stepien, Magdalena, primary, Plymoth, Amelie, primary, Muller, David, primary, Overvad, Kim, primary, Olsen, Anja, primary, Tjønneland, Anne, primary, Baglietto, Laura, primary, Severi, Gianluca, primary, Boutron-Ruault, Marie-Christine, primary, Turzanski-Fortner, Renee, primary, Kaaks, Rudolf, primary, Boeing, Heiner, primary, Aleksandrova, Krasimira, primary, Trichopoulou, Antonia, primary, Lagiou, Pagona, primary, Bamia, Christina, primary, Pala, Valeria, primary, Palli, Domenico, primary, Mattiello, Amalia, primary, Tumino, Rosario, primary, Naccarati, Alessio, primary, Bueno-de-Mesquita, H.B(as)., primary, Peeters, Petra H., primary, Weiderpass, Elisabete, primary, Quirós, J. Ramón, primary, Agudo, Antonio, primary, Sánchez-Cantalejo, Emilio, primary, Ardanaz, Eva, primary, Gavrila, Diana, primary, Dorronsoro, Miren, primary, Werner, Mårten, primary, Hemmingsson, Oskar, primary, Ohlsson, Bodil, primary, Sjöberg, Klas, primary, Wareham, Nicholas J., primary, Khaw, Kay-Tee, primary, Bradbury, Kathryn E., primary, Gunter, Marc J., primary, Cross, Amanda J., primary, Riboli, Elio, primary, Jenab, Mazda, primary, Hainaut, Pierre, primary, and Beretta, Laura, primary
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- 2023
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29. Cubic spline for the association between OPN levels and HCC from Circulating Osteopontin and Prediction of Hepatocellular Carcinoma Development in a Large European Population
- Author
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Duarte-Salles, Talita, primary, Misra, Sandeep, primary, Stepien, Magdalena, primary, Plymoth, Amelie, primary, Muller, David, primary, Overvad, Kim, primary, Olsen, Anja, primary, Tjønneland, Anne, primary, Baglietto, Laura, primary, Severi, Gianluca, primary, Boutron-Ruault, Marie-Christine, primary, Turzanski-Fortner, Renee, primary, Kaaks, Rudolf, primary, Boeing, Heiner, primary, Aleksandrova, Krasimira, primary, Trichopoulou, Antonia, primary, Lagiou, Pagona, primary, Bamia, Christina, primary, Pala, Valeria, primary, Palli, Domenico, primary, Mattiello, Amalia, primary, Tumino, Rosario, primary, Naccarati, Alessio, primary, Bueno-de-Mesquita, H.B(as)., primary, Peeters, Petra H., primary, Weiderpass, Elisabete, primary, Quirós, J. Ramón, primary, Agudo, Antonio, primary, Sánchez-Cantalejo, Emilio, primary, Ardanaz, Eva, primary, Gavrila, Diana, primary, Dorronsoro, Miren, primary, Werner, Mårten, primary, Hemmingsson, Oskar, primary, Ohlsson, Bodil, primary, Sjöberg, Klas, primary, Wareham, Nicholas J., primary, Khaw, Kay-Tee, primary, Bradbury, Kathryn E., primary, Gunter, Marc J., primary, Cross, Amanda J., primary, Riboli, Elio, primary, Jenab, Mazda, primary, Hainaut, Pierre, primary, and Beretta, Laura, primary
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- 2023
- Full Text
- View/download PDF
30. Supplementary Tables from Circulating Osteopontin and Prediction of Hepatocellular Carcinoma Development in a Large European Population
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Duarte-Salles, Talita, primary, Misra, Sandeep, primary, Stepien, Magdalena, primary, Plymoth, Amelie, primary, Muller, David, primary, Overvad, Kim, primary, Olsen, Anja, primary, Tjønneland, Anne, primary, Baglietto, Laura, primary, Severi, Gianluca, primary, Boutron-Ruault, Marie-Christine, primary, Turzanski-Fortner, Renee, primary, Kaaks, Rudolf, primary, Boeing, Heiner, primary, Aleksandrova, Krasimira, primary, Trichopoulou, Antonia, primary, Lagiou, Pagona, primary, Bamia, Christina, primary, Pala, Valeria, primary, Palli, Domenico, primary, Mattiello, Amalia, primary, Tumino, Rosario, primary, Naccarati, Alessio, primary, Bueno-de-Mesquita, H.B(as)., primary, Peeters, Petra H., primary, Weiderpass, Elisabete, primary, Quirós, J. Ramón, primary, Agudo, Antonio, primary, Sánchez-Cantalejo, Emilio, primary, Ardanaz, Eva, primary, Gavrila, Diana, primary, Dorronsoro, Miren, primary, Werner, Mårten, primary, Hemmingsson, Oskar, primary, Ohlsson, Bodil, primary, Sjöberg, Klas, primary, Wareham, Nicholas J., primary, Khaw, Kay-Tee, primary, Bradbury, Kathryn E., primary, Gunter, Marc J., primary, Cross, Amanda J., primary, Riboli, Elio, primary, Jenab, Mazda, primary, Hainaut, Pierre, primary, and Beretta, Laura, primary
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- 2023
- Full Text
- View/download PDF
31. Associations between dietary inflammatory scores and biomarkers of inflammation in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort
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Cardiometabolic Health, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Lécuyer, Lucie, Laouali, Nasser, Viallon, Vivian, Artaud, Fanny, Hébert, James R, Shivappa, Nitin, Agudo, Antonio, Tjønneland, Anne, Mellemkjær, Lene, Kaaks, Rudolf, Katzke, Verena A, Schulze, Matthias B, Frenoy, Pauline, Mancini, Francesca Romana, De Magistris, Maria Santucci, Macciotta, Alessandra, Masala, Giovanna, Agnoli, Claudia, Tumino, Rosario, Boer, Jolanda M A, Verschuren, W M Monique, Enget Jensen, Torill M, Olsen, Karina Standahl, Skeie, Guri, Chirlaque, María-Dolores, Petrova, Dafina, Castro-Espin, Carlota, Quirós, J Ramón, Guevara, Marcela, Amiano, Pilar, Borné, Yan, Sandström, Maria, Nilsson, Lena Maria, Heath, Alicia K, Mayen, Ana-Lucia, Huybrechts, Inge, Weiderpass, Elisabete, Boutron-Ruault, Marie-Christine, Dossus, Laure, Rinaldi, Sabina, Truong, Thérèse, Cardiometabolic Health, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Lécuyer, Lucie, Laouali, Nasser, Viallon, Vivian, Artaud, Fanny, Hébert, James R, Shivappa, Nitin, Agudo, Antonio, Tjønneland, Anne, Mellemkjær, Lene, Kaaks, Rudolf, Katzke, Verena A, Schulze, Matthias B, Frenoy, Pauline, Mancini, Francesca Romana, De Magistris, Maria Santucci, Macciotta, Alessandra, Masala, Giovanna, Agnoli, Claudia, Tumino, Rosario, Boer, Jolanda M A, Verschuren, W M Monique, Enget Jensen, Torill M, Olsen, Karina Standahl, Skeie, Guri, Chirlaque, María-Dolores, Petrova, Dafina, Castro-Espin, Carlota, Quirós, J Ramón, Guevara, Marcela, Amiano, Pilar, Borné, Yan, Sandström, Maria, Nilsson, Lena Maria, Heath, Alicia K, Mayen, Ana-Lucia, Huybrechts, Inge, Weiderpass, Elisabete, Boutron-Ruault, Marie-Christine, Dossus, Laure, Rinaldi, Sabina, and Truong, Thérèse
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- 2023
32. A body shape index (ABSI) is associated inversely with post-menopausal progesterone-receptor-negative breast cancer risk in a large European cohort
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Epi Kanker, Cancer, JC onderzoeksprogramma Kanker, Epi Kanker Team C, Christakoudi, Sofia, Tsilidis, Konstantinos K, Dossus, Laure, Rinaldi, Sabina, Weiderpass, Elisabete, Antoniussen, Christian S, Dahm, Christina C, Tjønneland, Anne, Mellemkjær, Lene, Katzke, Verena, Kaaks, Rudolf, Schulze, Matthias B, Masala, Giovanna, Grioni, Sara, Panico, Salvatore, Tumino, Rosario, Sacerdote, Carlotta, May, Anne M, Monninkhof, Evelyn M, Quirós, J Ramón, Bonet, Catalina, Sánchez, Maria-Jose, Amiano, Pilar, Chirlaque, María-Dolores, Guevara, Marcela, Rosendahl, Ann H, Stocks, Tanja, Perez-Cornago, Aurora, Tin Tin, Sandar, Heath, Alicia K, Aglago, Elom K, Peruchet-Noray, Laia, Freisling, Heinz, Riboli, Elio, Epi Kanker, Cancer, JC onderzoeksprogramma Kanker, Epi Kanker Team C, Christakoudi, Sofia, Tsilidis, Konstantinos K, Dossus, Laure, Rinaldi, Sabina, Weiderpass, Elisabete, Antoniussen, Christian S, Dahm, Christina C, Tjønneland, Anne, Mellemkjær, Lene, Katzke, Verena, Kaaks, Rudolf, Schulze, Matthias B, Masala, Giovanna, Grioni, Sara, Panico, Salvatore, Tumino, Rosario, Sacerdote, Carlotta, May, Anne M, Monninkhof, Evelyn M, Quirós, J Ramón, Bonet, Catalina, Sánchez, Maria-Jose, Amiano, Pilar, Chirlaque, María-Dolores, Guevara, Marcela, Rosendahl, Ann H, Stocks, Tanja, Perez-Cornago, Aurora, Tin Tin, Sandar, Heath, Alicia K, Aglago, Elom K, Peruchet-Noray, Laia, Freisling, Heinz, and Riboli, Elio
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- 2023
33. Sweet-beverage consumption and risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)
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Navarrete-Muñoz, Eva M, Wark, Petra A, Romaguera, Dora, Bhoo-Pathy, Nirmala, Michaud, Dominique, Molina-Montes, Esther, Tjønneland, Anne, Olsen, Anja, Overvad, Kim, Boutron-Ruault, Marie-Christine, Clavel-Chapelon, Françoise, Fagherazzi, Guy, Katzke, Verena A, Kühn, Tilman, Steffen, Annika, Trichopoulou, Antonia, Klinaki, Eleni, Papatesta, Eleni-Maria, Masala, Giovanna, Krogh, Vittorio, Tumino, Rosario, Naccarati, Alessio, Mattiello, Amalia, Peeters, Petra H, Rylander, Charlotta, Parr, Christine L, Skeie, Guri, Weiderpass, Elisabete, Quirós, J Ramón, Duell, Eric J, Dorronsoro, Miren, Huerta, José María, Ardanaz, Eva, Wareham, Nick, Khaw, Kay-Tee, Travis, Ruth C, Key, Tim, Stepien, Magdalena, Freisling, Heinz, Riboli, Elio, and Bueno-de-Mesquita, H Bas
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- 2016
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34. Prospective association of liver function biomarkers with development of hepatobiliary cancers
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Stepien, Magdalena, Fedirko, Veronika, Duarte-Salles, Talita, Ferrari, Pietro, Freisling, Heinz, Trepo, Elisabeth, Trichopoulou, Antonia, Bamia, Christina, Weiderpass, Elisabete, Olsen, Anja, Tjønneland, Anne, Overvad, Kim, Boutron-Ruault, Marie-Christine, Fagherazzi, Guy, Racine, Antoine, Kühn, Tilman, Kaaks, Rudolf, Aleksandrova, Krasimira, Boeing, Heiner, Lagiou, Pagona, Benetou, Vassiliki, Trichopoulos, Dimitrios, Palli, Domenico, Grioni, Sara, Tumino, Rosario, Naccarati, Alessio, Panico, Salvatore, Bueno-de-Mesquita, H. Bas., Peeters, Petra H., Lund, Eiliv, Quirós, J. Ramón, Nápoles, Osmel Companioni, Sánchez, María-José, Dorronsoro, Miren, Huerta, José María, Ardanaz, Eva, Ohlsson, Bodil, Sjöberg, Klas, Werner, Mårten, Nystrom, Hanna, Khaw, Kay-Tee, Key, Timothy J., Gunter, Marc, Cross, Amanda, Riboli, Elio, Romieu, Isabelle, and Jenab, Mazda
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- 2016
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35. Plasma carotenoids, vitamin C, tocopherols, and retinol and the risk of breast cancer in the European Prospective Investigation into Cancer and Nutrition cohort
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Bakker, Marije F, Peeters, Petra HM, Klaasen, Veronique M, Bueno-de-Mesquita, H Bas, Jansen, Eugene HJM, Ros, Martine M, Travier, Noémie, Olsen, Anja, Tjønneland, Anne, Overvad, Kim, Rinaldi, Sabina, Romieu, Isabelle, Brennan, Paul, Boutron-Ruault, Marie-Christine, Perquier, Florence, Cadeau, Claire, Boeing, Heiner, Aleksandrova, Krasimira, Kaaks, Rudolf, Kühn, Tilman, Trichopoulou, Antonia, Lagiou, Pagona, Trichopoulos, Dimitrios, Vineis, Paolo, Krogh, Vittorio, Panico, Salvatore, Masala, Giovanna, Tumino, Rosario, Weiderpass, Elisabete, Skeie, Guri, Lund, Eiliv, Quirós, J Ramón, Ardanaz, Eva, Navarro, Carmen, Amiano, Pilar, Sánchez, María-José, Buckland, Genevieve, Ericson, Ulrika, Sonestedt, Emily, Johansson, Matthias, Sund, Malin, Travis, Ruth C, Key, Timothy J, Khaw, Kay-Tee, Wareham, Nick, Riboli, Elio, and van Gils, Carla H
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- 2016
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36. Nutrient-wide association study of 57 foods/nutrients and epithelial ovarian cancer in the European Prospective Investigation into Cancer and Nutrition study and the Netherlands Cohort Study
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Merritt, Melissa A, Tzoulaki, Ioanna, van den Brandt, Piet A, Schouten, Leo J, Tsilidis, Konstantinos K, Weiderpass, Elisabete, Patel, Chirag J, Tjønneland, Anne, Hansen, Louise, Overvad, Kim, His, Mathilde, Dartois, Laureen, Boutron-Ruault, Marie-Christine, Fortner, Renée T, Kaaks, Rudolf, Aleksandrova, Krasimira, Boeing, Heiner, Trichopoulou, Antonia, Lagiou, Pagona, Bamia, Christina, Palli, Domenico, Krogh, Vittorio, Tumino, Rosario, Ricceri, Fulvio, Mattiello, Amalia, Bueno-de-Mesquita, H Bas, Onland-Moret, N Charlotte, Peeters, Petra H, Skeie, Guri, Jareid, Mie, Quirós, J Ramón, Obón-Santacana, Mireia, Sánchez, María-José, Chamosa, Saioa, Huerta, José M, Barricarte, Aurelio, Dias, Joana A, Sonestedt, Emily, Idahl, Annika, Lundin, Eva, Wareham, Nicholas J, Khaw, Kay-Tee, Travis, Ruth C, Ferrari, Pietro, Riboli, Elio, and Gunter, Marc J
- Published
- 2016
- Full Text
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37. Vegetable and fruit consumption and the risk of hormone receptor–defined breast cancer in the EPIC cohort
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Emaus, Marleen J, Peeters, Petra HM, Bakker, Marije F, Overvad, Kim, Tjønneland, Anne, Olsen, Anja, Romieu, Isabelle, Ferrari, Pietro, Dossus, Laure, Boutron-Ruault, Marie Christine, Baglietto, Laura, Fortner, Renée T, Kaaks, Rudolf, Boeing, Heiner, Trichopoulou, Antonia, Lagiou, Pagona, Trichopoulos, Dimitrios, Masala, Giovanna, Pala, Valeria, Panico, Salvatore, Tumino, Rosario, Polidoro, Silvia, Skeie, Guri, Lund, Eiliv, Weiderpass, Elisabete, Quirós, J Ramón, Travier, Noémie, Sánchez, María-José, Chirlaque, Maria-Dolores, Ardanaz, Eva, Dorronsoro, Miren, Winkvist, Anna, Wennberg, Maria, Bueno-de-Mesquita, H Bas, Khaw, Kay-Tee, Travis, Ruth C, Key, Timothy J, Aune, Dagfinn, Gunter, Marc, Riboli, Elio, and van Gils, Carla H
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- 2016
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38. Consumption of Meat, Fish, Dairy Products, and Eggs and Risk of Ischemic Heart Disease: A Prospective Study of 7198 Incident Cases Among 409 885 Participants in the Pan-European EPIC Cohort
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Key, Timothy J., Appleby, Paul N., Bradbury, Kathryn E., Sweeting, Michael, Wood, Angela, Johansson, Ingegerd, Kühn, Tilman, Steur, Marinka, Weiderpass, Elisabete, Wennberg, Maria, Lund Würtz, Anne Mette, Agudo, Antonio, Andersson, Jonas, Arriola, Larraitz, Boeing, Heiner, Boer, Jolanda M.A., Bonnet, Fabrice, Boutron-Ruault, Marie-Christine, Cross, Amanda J., Ericson, Ulrika, Fagherazzi, Guy, Ferrari, Pietro, Gunter, Marc, Huerta, José María, Katzke, Verena, Khaw, Kay-Tee, Krogh, Vittorio, La Vecchia, Carlo, Matullo, Giuseppe, Moreno-Iribas, Conchi, Naska, Androniki, Nilsson, Lena Maria, Olsen, Anja, Overvad, Kim, Palli, Domenico, Panico, Salvatore, Molina-Portillo, Elena, Quirós, J. Ramón, Skeie, Guri, Sluijs, Ivonne, Sonestedt, Emily, Stepien, Magdalena, Tjønneland, Anne, Trichopoulou, Antonia, Tumino, Rosario, Tzoulaki, Ioanna, van der Schouw, Yvonne T., Verschuren, W.M. Monique, di Angelantonio, Emanuele, Langenberg, Claudia, Forouhi, Nita, Wareham, Nick, Butterworth, Adam, Riboli, Elio, and Danesh, John
- Published
- 2019
- Full Text
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39. Development and validation of circulating CA125 prediction models in postmenopausal women
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Sasamoto, Naoko, Babic, Ana, Rosner, Bernard A., Fortner, Renée T., Vitonis, Allison F., Yamamoto, Hidemi, Fichorova, Raina N., Titus, Linda J., Tjønneland, Anne, Hansen, Louise, Kvaskoff, Marina, Fournier, Agnès, Mancini, Francesca Romana, Boeing, Heiner, Trichopoulou, Antonia, Peppa, Eleni, Karakatsani, Anna, Palli, Domenico, Grioni, Sara, Mattiello, Amalia, Tumino, Rosario, Fiano, Valentina, Onland-Moret, N. Charlotte, Weiderpass, Elisabete, Gram, Inger T., Quirós, J. Ramón, Lujan-Barroso, Leila, Sánchez, Maria-Jose, Colorado-Yohar, Sandra, Barricarte, Aurelio, Amiano, Pilar, Idahl, Annika, Lundin, Eva, Sartor, Hanna, Khaw, Kay-Tee, Key, Timothy J., Muller, David, Riboli, Elio, Gunter, Marc, Dossus, Laure, Trabert, Britton, Wentzensen, Nicolas, Kaaks, Rudolf, Cramer, Daniel W., Tworoger, Shelley S., and Terry, Kathryn L.
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- 2019
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40. Prospective analysis of circulating metabolites and breast cancer in EPIC
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His, Mathilde, Viallon, Vivian, Dossus, Laure, Gicquiau, Audrey, Achaintre, David, Scalbert, Augustin, Ferrari, Pietro, Romieu, Isabelle, Onland-Moret, N. Charlotte, Weiderpass, Elisabete, Dahm, Christina C., Overvad, Kim, Olsen, Anja, Tjønneland, Anne, Fournier, Agnès, Rothwell, Joseph A., Severi, Gianluca, Kühn, Tilman, Fortner, Renée T., Boeing, Heiner, Trichopoulou, Antonia, Karakatsani, Anna, Martimianaki, Georgia, Masala, Giovanna, Sieri, Sabina, Tumino, Rosario, Vineis, Paolo, Panico, Salvatore, van Gils, Carla H., Nøst, Therese H., Sandanger, Torkjel M., Skeie, Guri, Quirós, J. Ramón, Agudo, Antonio, Sánchez, Maria-Jose, Amiano, Pilar, Huerta, José María, Ardanaz, Eva, Schmidt, Julie A., Travis, Ruth C., Riboli, Elio, Tsilidis, Konstantinos K., Christakoudi, Sofia, Gunter, Marc J., and Rinaldi, Sabina
- Published
- 2019
- Full Text
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41. Supplementary Table 2 from Leukocyte Telomere Length in Relation to Pancreatic Cancer Risk: A Prospective Study
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Campa, Daniele, primary, Mergarten, Björn, primary, De Vivo, Immaculata, primary, Boutron-Ruault, Marie-Christine, primary, Racine, Antoine, primary, Severi, Gianluca, primary, Nieters, Alexandra, primary, Katzke, Verena A., primary, Trichopoulou, Antonia, primary, Yiannakouris, Nikos, primary, Trichopoulos, Dimitrios, primary, Boeing, Heiner, primary, Quirós, J. Ramón, primary, Duell, Eric J., primary, Molina-Montes, Esther, primary, Huerta, José María, primary, Ardanaz, Eva, primary, Dorronsoro, Miren, primary, Khaw, Kay-Tee, primary, Wareham, Nicholas, primary, Travis, Ruth C., primary, Palli, Domenico, primary, Pala, Valeria, primary, Tumino, Rosario, primary, Naccarati, Alessio, primary, Panico, Salvatore, primary, Vineis, Paolo, primary, Riboli, Elio, primary, Siddiq, Afshan, primary, Bueno-de-Mesquita, H.B., primary, Peeters, Petra H., primary, Nilsson, Peter M., primary, Sund, Malin, primary, Ye, Weimin, primary, Lund, Eiliv, primary, Jareid, Mie, primary, Weiderpass, Elisabete, primary, Duarte-Salles, Talita, primary, Kong, So Yeon, primary, Stepien, Magdalena, primary, Canzian, Federico, primary, and Kaaks, Rudolf, primary
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- 2023
- Full Text
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42. Supplementary Table 1 from Leukocyte Telomere Length in Relation to Pancreatic Cancer Risk: A Prospective Study
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Campa, Daniele, primary, Mergarten, Björn, primary, De Vivo, Immaculata, primary, Boutron-Ruault, Marie-Christine, primary, Racine, Antoine, primary, Severi, Gianluca, primary, Nieters, Alexandra, primary, Katzke, Verena A., primary, Trichopoulou, Antonia, primary, Yiannakouris, Nikos, primary, Trichopoulos, Dimitrios, primary, Boeing, Heiner, primary, Quirós, J. Ramón, primary, Duell, Eric J., primary, Molina-Montes, Esther, primary, Huerta, José María, primary, Ardanaz, Eva, primary, Dorronsoro, Miren, primary, Khaw, Kay-Tee, primary, Wareham, Nicholas, primary, Travis, Ruth C., primary, Palli, Domenico, primary, Pala, Valeria, primary, Tumino, Rosario, primary, Naccarati, Alessio, primary, Panico, Salvatore, primary, Vineis, Paolo, primary, Riboli, Elio, primary, Siddiq, Afshan, primary, Bueno-de-Mesquita, H.B., primary, Peeters, Petra H., primary, Nilsson, Peter M., primary, Sund, Malin, primary, Ye, Weimin, primary, Lund, Eiliv, primary, Jareid, Mie, primary, Weiderpass, Elisabete, primary, Duarte-Salles, Talita, primary, Kong, So Yeon, primary, Stepien, Magdalena, primary, Canzian, Federico, primary, and Kaaks, Rudolf, primary
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- 2023
- Full Text
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43. Supplemental Material and Methods, Tables S1-S6, Figure S1 from Investigation of Dietary Factors and Endometrial Cancer Risk Using a Nutrient-wide Association Study Approach in the EPIC and Nurses' Health Study (NHS) and NHSII
- Author
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Merritt, Melissa A., primary, Tzoulaki, Ioanna, primary, Tworoger, Shelley S., primary, De Vivo, Immaculata, primary, Hankinson, Susan E., primary, Fernandes, Judy, primary, Tsilidis, Konstantinos K., primary, Weiderpass, Elisabete, primary, Tjønneland, Anne, primary, Petersen, Kristina E.N., primary, Dahm, Christina C., primary, Overvad, Kim, primary, Dossus, Laure, primary, Boutron-Ruault, Marie-Christine, primary, Fagherazzi, Guy, primary, Fortner, Renée T., primary, Kaaks, Rudolf, primary, Aleksandrova, Krasimira, primary, Boeing, Heiner, primary, Trichopoulou, Antonia, primary, Bamia, Christina, primary, Trichopoulos, Dimitrios, primary, Palli, Domenico, primary, Grioni, Sara, primary, Tumino, Rosario, primary, Sacerdote, Carlotta, primary, Mattiello, Amalia, primary, Bueno-de-Mesquita, H.B(as)., primary, Onland-Moret, N. Charlotte, primary, Peeters, Petra H., primary, Gram, Inger T., primary, Skeie, Guri, primary, Quirós, J. Ramón, primary, Duell, Eric J., primary, Sánchez, María-José, primary, Salmerón, D., primary, Barricarte, Aurelio, primary, Chamosa, Saioa, primary, Ericson, Ulrica, primary, Sonestedt, Emily, primary, Nilsson, Lena Maria, primary, Idahl, Annika, primary, Khaw, Kay-Tee, primary, Wareham, Nicholas, primary, Travis, Ruth C., primary, Rinaldi, Sabina, primary, Romieu, Isabelle, primary, Patel, Chirag J., primary, Riboli, Elio, primary, and Gunter, Marc J., primary
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- 2023
- Full Text
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44. Supplementary Figure 1 from Leukocyte Telomere Length in Relation to Pancreatic Cancer Risk: A Prospective Study
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Campa, Daniele, primary, Mergarten, Björn, primary, De Vivo, Immaculata, primary, Boutron-Ruault, Marie-Christine, primary, Racine, Antoine, primary, Severi, Gianluca, primary, Nieters, Alexandra, primary, Katzke, Verena A., primary, Trichopoulou, Antonia, primary, Yiannakouris, Nikos, primary, Trichopoulos, Dimitrios, primary, Boeing, Heiner, primary, Quirós, J. Ramón, primary, Duell, Eric J., primary, Molina-Montes, Esther, primary, Huerta, José María, primary, Ardanaz, Eva, primary, Dorronsoro, Miren, primary, Khaw, Kay-Tee, primary, Wareham, Nicholas, primary, Travis, Ruth C., primary, Palli, Domenico, primary, Pala, Valeria, primary, Tumino, Rosario, primary, Naccarati, Alessio, primary, Panico, Salvatore, primary, Vineis, Paolo, primary, Riboli, Elio, primary, Siddiq, Afshan, primary, Bueno-de-Mesquita, H.B., primary, Peeters, Petra H., primary, Nilsson, Peter M., primary, Sund, Malin, primary, Ye, Weimin, primary, Lund, Eiliv, primary, Jareid, Mie, primary, Weiderpass, Elisabete, primary, Duarte-Salles, Talita, primary, Kong, So Yeon, primary, Stepien, Magdalena, primary, Canzian, Federico, primary, and Kaaks, Rudolf, primary
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- 2023
- Full Text
- View/download PDF
45. Supplementary Material (Table S1-S3, Figure S1-S2) from High Levels of C-Reactive Protein Are Associated with an Increased Risk of Ovarian Cancer: Results from the Ovarian Cancer Cohort Consortium
- Author
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Peres, Lauren C., primary, Mallen, Adrianne R., primary, Townsend, Mary K., primary, Poole, Elizabeth M., primary, Trabert, Britton, primary, Allen, Naomi E., primary, Arslan, Alan A., primary, Dossus, Laure, primary, Fortner, Renée T., primary, Gram, Inger T., primary, Hartge, Patricia, primary, Idahl, Annika, primary, Kaaks, Rudolf, primary, Kvaskoff, Marina, primary, Magliocco, Anthony M., primary, Merritt, Melissa A., primary, Quirós, J. Ramón, primary, Tjonneland, Anne, primary, Trichopoulou, Antonia, primary, Tumino, Rosario, primary, van Gils, Carla H., primary, Visvanathan, Kala, primary, Wentzensen, Nicolas, primary, Zeleniuch-Jacquotte, Anne, primary, and Tworoger, Shelley S., primary
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- 2023
- Full Text
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46. Data from High Levels of C-Reactive Protein Are Associated with an Increased Risk of Ovarian Cancer: Results from the Ovarian Cancer Cohort Consortium
- Author
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Peres, Lauren C., primary, Mallen, Adrianne R., primary, Townsend, Mary K., primary, Poole, Elizabeth M., primary, Trabert, Britton, primary, Allen, Naomi E., primary, Arslan, Alan A., primary, Dossus, Laure, primary, Fortner, Renée T., primary, Gram, Inger T., primary, Hartge, Patricia, primary, Idahl, Annika, primary, Kaaks, Rudolf, primary, Kvaskoff, Marina, primary, Magliocco, Anthony M., primary, Merritt, Melissa A., primary, Quirós, J. Ramón, primary, Tjonneland, Anne, primary, Trichopoulou, Antonia, primary, Tumino, Rosario, primary, van Gils, Carla H., primary, Visvanathan, Kala, primary, Wentzensen, Nicolas, primary, Zeleniuch-Jacquotte, Anne, primary, and Tworoger, Shelley S., primary
- Published
- 2023
- Full Text
- View/download PDF
47. Supplemental Tables S1-S3 from Serum Endotoxins and Flagellin and Risk of Colorectal Cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) Cohort
- Author
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Kong, So Yeon, primary, Tran, Hao Quang, primary, Gewirtz, Andrew T., primary, McKeown-Eyssen, Gail, primary, Fedirko, Veronika, primary, Romieu, Isabelle, primary, Tjønneland, Anne, primary, Olsen, Anja, primary, Overvad, Kim, primary, Boutron-Ruault, Marie-Christine, primary, Bastide, Nadia, primary, Affret, Aurélie, primary, Kühn, Tilman, primary, Kaaks, Rudolf, primary, Boeing, Heiner, primary, Aleksandrova, Krasimira, primary, Trichopoulou, Antonia, primary, Kritikou, Maria, primary, Vasilopoulou, Effie, primary, Palli, Domenico, primary, Krogh, Vittorio, primary, Mattiello, Amalia, primary, Tumino, Rosario, primary, Naccarati, Alessio, primary, Bueno-de-Mesquita, H.B., primary, Peeters, Petra H., primary, Weiderpass, Elisabete, primary, Quirós, J. Ramón, primary, Sala, Núria, primary, Sánchez, María-José, primary, Castaño, José María Huerta, primary, Barricarte, Aurelio, primary, Dorronsoro, Miren, primary, Werner, Mårten, primary, Wareham, Nicholas J., primary, Khaw, Kay-Tee, primary, Bradbury, Kathryn E., primary, Freisling, Heinz, primary, Stavropoulou, Faidra, primary, Ferrari, Pietro, primary, Gunter, Marc J., primary, Cross, Amanda J., primary, Riboli, Elio, primary, Bruce, W. Robert, primary, and Jenab, Mazda, primary
- Published
- 2023
- Full Text
- View/download PDF
48. Supplementary Material from KIM-1 as a Blood-Based Marker for Early Detection of Kidney Cancer: A Prospective Nested Case–Control Study
- Author
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Scelo, Ghislaine, primary, Muller, David C., primary, Riboli, Elio, primary, Johansson, Mattias, primary, Cross, Amanda J., primary, Vineis, Paolo, primary, Tsilidis, Konstantinos K., primary, Brennan, Paul, primary, Boeing, Heiner, primary, Peeters, Petra H.M., primary, Vermeulen, Roel C.H., primary, Overvad, Kim, primary, Bueno-de-Mesquita, H. Bas, primary, Severi, Gianluca, primary, Perduca, Vittorio, primary, Kvaskoff, Marina, primary, Trichopoulou, Antonia, primary, La Vecchia, Carlo, primary, Karakatsani, Anna, primary, Palli, Domenico, primary, Sieri, Sabina, primary, Panico, Salvatore, primary, Weiderpass, Elisabete, primary, Sandanger, Torkjel M., primary, Nøst, Therese H., primary, Agudo, Antonio, primary, Quirós, J. Ramón, primary, Rodríguez-Barranco, Miguel, primary, Chirlaque, Maria-Dolores, primary, Key, Timothy J., primary, Khanna, Prateek, primary, Bonventre, Joseph V., primary, Sabbisetti, Venkata S., primary, and Bhatt, Rupal S., primary
- Published
- 2023
- Full Text
- View/download PDF
49. Supplemental Tables 1-3 from Added Value of Serum Hormone Measurements in Risk Prediction Models for Breast Cancer for Women Not Using Exogenous Hormones: Results from the EPIC Cohort
- Author
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Hüsing, Anika, primary, Fortner, Renée T., primary, Kühn, Tilman, primary, Overvad, Kim, primary, Tjønneland, Anne, primary, Olsen, Anja, primary, Boutron-Ruault, Marie-Christine, primary, Severi, Gianluca, primary, Fournier, Agnes, primary, Boeing, Heiner, primary, Trichopoulou, Antonia, primary, Benetou, Vassiliki, primary, Orfanos, Philippos, primary, Masala, Giovanna, primary, Pala, Valeria, primary, Tumino, Rosario, primary, Fasanelli, Francesca, primary, Panico, Salvatore, primary, Bueno de Mesquita, H. Bas, primary, Peeters, Petra H., primary, van Gills, Carla H., primary, Quirós, J. Ramón, primary, Agudo, Antonio, primary, Sánchez, Maria-Jose, primary, Chirlaque, Maria-Dolores, primary, Barricarte, Aurelio, primary, Amiano, Pilar, primary, Khaw, Kay-Tee, primary, Travis, Ruth C., primary, Dossus, Laure, primary, Li, Kuanrong, primary, Ferrari, Pietro, primary, Merritt, Melissa A., primary, Tzoulaki, Ioanna, primary, Riboli, Elio, primary, and Kaaks, Rudolf, primary
- Published
- 2023
- Full Text
- View/download PDF
50. Data from No Causal Association Identified for Human Papillomavirus Infections in Lung Cancer
- Author
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Anantharaman, Devasena, primary, Gheit, Tarik, primary, Waterboer, Tim, primary, Halec, Gordana, primary, Carreira, Christine, primary, Abedi-Ardekani, Behnoush, primary, McKay-Chopin, Sandrine, primary, Zaridze, David, primary, Mukeria, Anush, primary, Szeszenia-Dabrowska, Neonila, primary, Lissowska, Jolanta, primary, Mates, Dana, primary, Janout, Vladimir, primary, Foretova, Lenka, primary, Bencko, Vladimir, primary, Rudnai, Peter, primary, Fabianova, Eleonora, primary, Tjønneland, Anne, primary, Travis, Ruth C., primary, Boeing, Heiner, primary, Quirós, J. Ramón, primary, Johansson, Mikael, primary, Krogh, Vittorio, primary, Bueno-de-Mesquita, H. Bas, primary, Kotanidou, Anastasia, primary, Clavel-Chapelon, Françoise, primary, Weiderpass, Elisabete, primary, Johansson, Mattias, primary, Pawlita, Michael, primary, Scelo, Ghislaine, primary, Tommasino, Massimo, primary, and Brennan, Paul, primary
- Published
- 2023
- Full Text
- View/download PDF
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