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983 results on '"Qvist, Niels"'

12. Ernica Clinical Consensus Statements on Total Colonic and Intestinal Aganglionosis

Author

Granström, Anna Löf, Irvine, Willemijn, Hoel, Anders Telle, Tabbers, Merit, Kyrklund, Kristiina, Fascetti-Leon, Francesco, Fusaro, Fabio, Thapar, Nikhil, Dariel, Anne, Sloots, Cornelius E.J., Miserez, Marc, Lemli, Annette, Alexander, Sabine, Lambe, Cecile, Crétolle, Célia, Qvist, Niels, Schukfeh, Nagoud, Lacher, Martin, Cavalieri, Duccio, van Heurn, Ernst, Sfeir, Rony, Pakarinen, Mikko P., Bjørnland, Kristin, and Wester, Tomas

Published
2024
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16. Vacuum-assisted closure versus on-demand relaparotomy in patients with secondary peritonitis—the VACOR trial: protocol for a randomised controlled trial

Author

Rajabaleyan, Pooya, Michelsen, Jens, Tange Holst, Uffe, Möller, Sören, Toft, Palle, Luxhøi, Jan, Buyukuslu, Musa, Bohm, Aske Mathias, Borly, Lars, Sandblom, Gabriel, Kobborg, Martin, Aagaard Poulsen, Kristian, Schou Løve, Uffe, Ovesen, Sophie, Grant Sølling, Christoffer, Mørch Søndergaard, Birgitte, Lund Lomholt, Marianne, Ritz Møller, Dorthe, Qvist, Niels, and Bremholm Ellebæk, Mark

Published
2022
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20. The impact of iron deficiency on patients under evaluation for colorectal cancer, a prospective cross-sectional study.

Author

Ploug, Magnus, Qvist, Niels, Jacobsen, Birgitte Gade, Kroijer, Rasmus, Nielsen, Jan, and Knudsen, Torben

Subjects
*IRON deficiency, *MUSCLE strength testing, *GRIP strength, *COLORECTAL cancer, *CANCER fatigue
Abstract

Background and objective: Iron deficiency affects more than 60% of colorectal cancer patients at the time of diagnosis. Iron deficiency ultimately leads to anemia, but additionally, iron deficiency might impact other domains of colorectal cancer patients' health and well-being. The aim of this study was to evaluate the impact of iron deficiency on fatigue, quality of life, cognition, and physical ability in patients undergoing evaluation for colorectal cancer. Methods: Multicenter, prospective, observational cross-sectional study (2021–2023). Fatigue was the primary outcome, measured using the Focused Assessment of Cancer Treatment-Anemia questionnaire (FACT-An). Quality of Life, Cognition, Aerobe capacity, mobility, and peripheral muscle strength were tested as secondary outcomes. Multivariate analysis was performed to estimate the impact of iron deficiency on all outcomes. Results: Two hundred and one patients were analyzed, 57% being iron deficient. In multivariate regression analysis, iron deficiency was not associated with fatigue: FACT-An (r = −1.17, p = 0.57, 25% CI: −5.27 to 2.92). Results on quality of life, cognition, and mobility were non-significant and with small regression coefficients. Iron deficiency showed a nearly significant association with reduced hand-grip-strength (r = −3.47 kg, p = 0.06, 25%CI −7.03 to 0.08) and reduced 6 min walking distance (r = −40.36 m, p = 0.07, 25%CI: −84.73 to 4.00). Conclusion: Iron deficiency in patients undergoing evaluation for colorectal cancer was not associated with fatigue, quality of life, or cognition, but might affect aerobic endurance and peripheral muscle strength to a degree that is clinically relevant. [ABSTRACT FROM AUTHOR]

Published
2024
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39. Watchful waiting after radiological guided drainage of intra-abdominal abscess in patients with Crohn’s disease might be associated with increased rates of stoma construction

Author

El-Hussuna, Alaa, primary, Steenholdt, Casper, additional, Merrild Karer, Mette Louise, additional, Nyggard Uldall Nielsen, Natasja, additional, Mujukian, Angela, additional, Fleshner, Phillip R, additional, Iesalnieks, Igors, additional, Horesh, Nir, additional, Kopylov, Uri, additional, Jacoby, Harel, additional, Al-Qaisi, Haider Mahmoud, additional, Colombo, Francesco, additional, Sampietro, Gianluca M, additional, Marino, Marco V, additional, Ellebæk, Mark, additional, Sørensen, Nina, additional, Celentano, Valerio, additional, Ladwa, Nikhil, additional, Warusavitarne, Janindra, additional, Pellino, Gianluca, additional, Zeb, Aurang, additional, Di Candido, Francesca, additional, Hurtado-Pardo, Luis, additional, Frasson, Matteo, additional, Kunovsky, Lumir, additional, Yalcinkaya, Ali, additional, Alonso, Sandra, additional, Pera, Miguel, additional, Rodríguez, Cristina Antón, additional, Minaya, Ana, additional, Granero, Alvaro Garcia, additional, Tatar, Ozan Can, additional, Spinelli, Antonino, additional, and Qvist, Niels, additional

Published
2023
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43. Early Pre- and Postoperative Enteral Nutrition and Growth in Infants with Symptomatic Congenital Diaphragmatic Hernia.

Author

Larsen, Ulla Lei, Zachariassen, Gitte, Möller, Sören, Førre, Wilhelmine Ursin, Grøsle, Ingvild, Halken, Susanne, Herskind, Anne Maria, Strøm, Thomas, Toft, Palle, Ellebæk, Mark, and Qvist, Niels

Subjects
ENTERAL feeding, DIAPHRAGMATIC hernia, INFANT nutrition, INFANT growth, PEDIATRIC intensive care, BIRTH weight
Abstract

Objectives Nutritional support during the neonatal and postoperative period in congenital diaphragmatic hernia (CDH) is challenging and controversial. We aimed to report on early enteral nutritional support in symptomatic CDH patients during the pre- and postoperative period, including feasibility, associated factors with established full enteral nutrition, and weight at birth, discharge, and 18 months. Methods We retrospectively collected data on nutrition: type and volume of enteral nutrition and parental support. Enteral feeding was introduced preoperatively from day 1 after birth, increased step-wised (breastmilk preferred), and resumed after CDH repair on the first postoperative day. Baseline data were available from our CDH database. Results From 2011 to 2020, we identified 45 CDH infants. Twenty-two were girls (51.1%), 35 left sided (77.8%), and 40 underwent CDH repair (88.9%). Median (interquartile range) length of stay in the pediatric intensive care unit was 14.6 days (6.0–26.5), and 1-year mortality was 17.8%. Postoperatively, 120 and 160 mL/kg/d of enteral nutrition was achieved after a median of 6.5 (3.6–12.6) and 10.6 (7.6–21.7) days, respectively. In total, 31 (68.9%) needed supplemental parenteral nutrition in a median period of 8 days (5–18), and of those 11 had parenteral nutrition initiated before CDH repair. No complications to enteral feeding were reported. Conclusion Early enteral nutrition in CDH infants is feasible and may have the potential to reduce the need for parental nutrition and reduce time to full enteral nutrition in the postoperative period. [ABSTRACT FROM AUTHOR]

Published
2023
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44. A population-based nationwide study on total colectomy for ulcerative colitis and risk of ten prevalent inflammatory or autoimmune diseases.

Author

Mark-Christensen, Anders, Jølving, Line Riis, Anru, Pavithra Laxsen, Murray, Joseph A., Nielsen, Rasmus Gaardskær, Qvist, Niels, Laurberg, Søren, Engberg, Henriette, Kjeldsen, Jens, and Nørgård, Bente Mertz

Subjects
ULCERATIVE colitis, COLECTOMY, AUTOIMMUNE diseases, GUT microbiome, BACTERIAL diversity, MEDICAL registries
Abstract

There is growing evidence to support a role of the gut microbiome in the development of chronic inflammatory and autoimmune disease (IAD). We used total colectomy (TC) for ulcerative colitis (UC) as a model for a significant disruption in gut microbiome to explore an association with subsequent risk of IAD. We identified all patients with UC and no diagnosis of IAD prior to their UC diagnosis in Denmark from 1988 to 2015. Patients were followed from the date of UC to a diagnosis of IAD, death or end of follow-up, whichever occurred first. We used Cox regression to estimate hazard ratios (HRs) of IAD associated with TC, adjusting for age, sex, Charlson Comorbidity Index, and calendar year of UC diagnosis. 30,507 patients with UC (3,155 with TC and 27,352 without) were identified from the Danish National Patient Registry. During 43,266 person-years of follow-up, 2733 patients were diagnosed with an IAD. The risk of any IAD was higher for patients with TC compared to patients without (adjusted HR [aHR] 1.39 (95% CI: 1.24–1.57)). When the analyses were adjusted for exposure to antibiotics, immunomodulatory medicine and biologics (covering 2005–2018), the risk of IAD was still higher for patients with total colectomy (aHR = 1.41 (95% CI: 1.09;1.83)). Disease-specific analyses were weakened by a low number of outcomes. The risk of IAD was higher for patients who underwent TC for UC compared to patients who did not. What is already known? o The gut microbiome plays an important role in host immune homeostasis, and changes in gut bacterial diversity and composition may change the individual's risk of inflammatory and autoimmune disease (IAD). What is new here? o Patients with ulcerative colitis who undergo total colectomy have a higher risk of being diagnosed with IAD, compared to patients with ulcerative colitis who do not undergo total colectomy. How can this study help patient care? o Future research can help uncover the mechanisms responsible for the higher risk of certain IADs after total colectomy. If the microbiome plays a role, modifying the gut microbiome could prove a viable therapeutic strategy to reduce the risk of developing IADs. In this nationwide Danish cohort study of all Danish UC patients diagnosed in the period from 1988 to 2015, the risk of being diagnosed with inflammatory and autoimmune disease is higher for patients who underwent total colectomy compared to UC patients without total colectomy. [ABSTRACT FROM AUTHOR]

Published
2023
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46. Whole genome sequencing and disease pattern in patients with juvenile polyposis syndrome:a nationwide study

Author

Jelsig, Anne Marie, van Overeem Hansen, Thomas, Gede, Lene Bjerring, Qvist, Niels, Christensen, Lise-Lotte, Lautrup, Charlotte Kvist, Ljungmann, Ken, Christensen, Louise Torp, Rønlund, Karina, Tørring, Pernille Mathiesen, Bertelsen, Birgitte, Sunde, Lone, and Karstensen, John Gásdal

Subjects
Hereditary, Polyp, Juvenile, Syndrome, Cancer
Abstract

Juvenile polyposis syndrome (JPS) is a hereditary hamartomatous polyposis syndrome characterized by gastrointestinal juvenile polyps and increased risk of gastrointestinal cancer. Germline pathogenic variants are detected in SMAD4 or BMPR1A, however in a significant number of patients with JPS, the etiology is unknown. From Danish registers, and genetic department and laboratories, we identified all patients in Denmark with a clinical diagnosis of JPS and/or a pathogenic variant in BMPR1A or SMAD4. In patients where no variant had been detected, we performed genetic analysis, including whole genome sequencing. We collected clinical information on all patients to investigate the phenotypic spectrum. Sixty-six patients (mean age 40 years) were included of whom the pathogenic variant was unknown in seven patients. We detected a pathogenic variant in SMAD4 or PTEN in additional three patients and thus ≈ 95% of patients had a pathogenic germline variant. Endoscopic information was available in fifty-two patients (79%) and of these 31 (60%) fulfilled the clinical criteria of JPS. In 41 patients (79%), other types of polyps than juvenile had been removed. Our results suggest that almost all patients with a clinical diagnosis of JPS has a pathogenic variant in mainly BMPR1A, SMAD4, and more rarely PTEN. However, not all patients with a pathogenic variant fulfil the clinical criteria of JPS. We also demonstrated a wide clinical spectrum, and that the histopathology of removed polyps varied.

Published
2023

49. Survival, surveillance, and genetics in patients with Peutz–Jeghers syndrome: A nationwide study

Author

Jelsig, Anne Marie, primary, van Overeem Hansen, Thomas, additional, Gede, Lene Bjerring, additional, Qvist, Niels, additional, Christensen, Lise‐Lotte, additional, Lautrup, Charlotte Kvist, additional, Frederiksen, Jane Hübertz, additional, Sunde, Lone, additional, Ousager, Lilian Bomme, additional, Ljungmann, Ken, additional, Bertelsen, Birgitte, additional, and Karstensen, John Gásdal, additional

Published
2023
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