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1. Collaborative Problem-Solving in Knowledge-Rich Domains: A Multi-Study Structural Equation Model

Author: Laura Brandl, Matthias Stadler, Constanze Richters, Anika Radkowitsch, Martin R. Fischer, Ralf Schmidmaier, and Frank Fischer
Abstract: Collaborative skills are crucial in knowledge-rich domains, such as medical diagnosing. The Collaborative Diagnostic Reasoning (CDR) model emphasizes the importance of high-quality collaborative diagnostic activities (CDAs; e.g., evidence elicitation and sharing), influenced by content and collaboration knowledge as well as more general social skills, to achieve accurate, justified, and efficient diagnostic outcomes (Radkowitsch et al., 2022). However, it has not yet been empirically tested, and the relationships between individual characteristics, CDAs, and diagnostic outcomes remain largely unexplored. The aim of this study was to test the CDR model by analyzing data from three studies in a simulation-based environment and to better understand the construct and the processes involved (N = 504 intermediate medical students) using a structural equation model including indirect effects. We found various stable relationships between individual characteristics and CDAs, and between CDAs and diagnostic outcome, highlighting the multidimensional nature of CDR. While both content and collaboration knowledge were important for CDAs, none of the individual characteristics directly related to diagnostic outcome. The study suggests that CDAs are important factors in achieving successful diagnoses in collaborative contexts, particularly in simulation-based settings. CDAs are influenced by content and collaboration knowledge, highlighting the importance of understanding collaboration partners' knowledge. We propose revising the CDR model by assigning higher priority to collaboration knowledge compared with social skills, and dividing the CDAs into information elicitation and sharing, with sharing being more transactive. Training should focus on the development of CDAs to improve CDR skills.
Published: 2024
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2. Promoting Diagnostic Reasoning in Teacher Education: The Role of Case Format and Perceived Authenticity

Author: Sarah Bichler, Michael Sailer, Elisabeth Bauer, Jan Kiesewetter, Hanna Härtl, Martin R. Fischer, and Frank Fischer
Abstract: Teachers routinely observe and interpret student behavior to make judgements about whether and how to support their students' learning. Simulated cases can help pre-service teachers to gain this skill of diagnostic reasoning. With 118 pre-service teachers, we tested whether participants rate simulated cases presented in a serial-cue case format as more authentic and become more involved with the materials compared to cases presented in a whole case format. We further investigated whether participants with varying prior conceptual knowledge (what are symptoms of ADHD and dyslexia) gain more strategic knowledge (how to detect ADHD and dyslexia) with a serial-cue versus whole case format. We found that the case format did not impact authenticity ratings but that learners reported higher involvement in the serial-cue case format condition. Bayes factors provide moderate evidence for the absence of a case format effect on strategic knowledge and strong evidence for the absence of an interaction of case format and prior knowledge. We recommend using serial-cue case formats in simulations as they are a more authentic representation of the diagnostic reasoning process and cognitively involve learners. We call for replications to gather more evidence for the impact of case format on knowledge acquisition. We suggest a further inquiry into the relationship of case format, involvement, and authenticity but think that a productive way forward for designing authentic simulations is attention to aspects that make serial-cue cases effective for diverse learners. For example, adaptive feedback or targeted practice of specific parts of diagnostic reasoning such as weighing evidence.
Published: 2024
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3. Perceived Authenticity across Three Forms of Educational Simulations--The Role of Interactant Representation, Task Alignment, and Continuity of Simulation

Author: Caroline Corves, Matthias Stadler, and Martin R. Fischer
Abstract: Authenticity in simulation-based learning is linked to cognitive processes implicated in learning. However, evidence on authenticity across formats is insufficient. We compared three case-based settings and investigated the effect of discontinuity in simulation on perceived authenticity. In a quasi-experiment, we compared formats of simulation in the context of medical education. All formats simulated anamnestic interviews with varying interactant and task representations using highly comparable designs. Interactants (patients) were simulated by (a) live actors (standardized patients), (b) live fellow students (roleplays), or (c) question menus and videoclips (virtual patients). The continuity of simulations varied. We measured perceived authenticity with three subscales: Realness, Involvement, and Spatial Presence. We employed confirmatory factor analysis (CFA) to assess measurement invariance across settings and analysis of variance on authenticity ratings to compare the effects of setting and discontinuous simulation. CFA supported the assumption of invariance. Settings differed in Realness and Spatial Presence but not Involvement. Discontinuous simulations yielded significantly lower ratings of authenticity than continuous simulations. The compared simulation modalities offer different advantages with respect to their perceived authenticity profiles. Lower levels of interactivity and reduced subtask representation do not necessarily lead to lower ratings of perceived authenticity. Spatial Presence can be as high for media-based simulation as for roleplays. Discontinuation of simulations by offering scaffolding impairs perceived authenticity. Scaffolds may be designed to avoid discontinuation of simulation to uphold perceived authenticity.
Published: 2024
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4. Implementing Clinical Case Discussions to Enhance Clinical Reasoning Skills: A Pilot Study in an Italian Medical School

Author: Valentina Colonnello, Aurelia Zodl, Davide Agnoletti, Kilian Lischeid, Lena Cimbalnik, Marc Weidenbusch, Martin R. Fischer, Fabrizio De Ponti, and Christian Rausch
Subjects: clinical reasoning, clinical case discussions, case-based learning, medical education, peer teaching, curriculum development, Special aspects of education, LC8-6691, Medicine
Abstract: Background: Clinical reasoning (CR) is fundamental in medical education. However, the Italian curriculum has not incorporated a structured CR format yet. Therefore, we introduced the Clinical Case Discussions (CCD), to medical students attending the University of Bologna as a tool for developing CR abilities. CCDs are a case-based peer-teaching format, simulating the diagnostic process using published patient cases. Methods: Students of all clinical years of the University of Bologna Medical School were invited to voluntarily participate in a two-day CCD training program. They completed pre- and post-training questionnaires assessing their expectations before and impressions after the training and comparing learning outcomes to their usual classes. Results: Twenty-one students participated in this pilot program. Before the training, more than half of the participants expressed either interest or a strong interest in all proposed learning objectives. Afterward, 84.6% of the students stated that the training much exceeded (63.5%) or exceeded (23.1%) their expectations considering its utility for their future medical activities. A total of 92.3% strongly agreed (84.6%) or agreed (7.7%) to have improved their CR. Conclusions: Although this pilot program had some intrinsic limitations, the students’ positive feedback on this CCD format (combining the benefits of case-based learning and peer teaching) encourages further research on its potential role in the Italian curriculum.
Published: 2024
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5. Interaction between overconfidence effects and training formats in nurses’ education in hand hygiene

Author: Julia Seidel-Fischer, Milena Trifunovic-Koenig, Bianka Gerber, Baerbel Otto, Michael Bentele, Martin R. Fischer, and Stefan Bushuven
Subjects: Hand hygiene, Hand disinfection, Learning format, Metacognition, ICAP-model, Nursing, RT1-120
Abstract: Abstract Background Undergraduate training in hand hygiene is a keystone of infection control. Several studies have shown overconfidence effects in hand hygiene practices, which can impair metacognition. We hypothesized that overconfidence might be prevalent in the early education stages of nursing students and that these effects could be reduced through frequent interactive learning formats, such as learning groups. Methods We conducted a multicenter cross-sectional questionnaire with 196 German nursing students, including general, surgical, and anesthetic nursing specializations. Results Overconfidence was observed in nursing students across all specialties and years of education. The cluster analyses showed three different types of learners: two characterized by overconfidence and one demonstrating justifiable confidence. Furthermore, the moderation analysis indicated that providing feedback and promoting metacognition regarding students’ learning achievements could mitigate overplacement, particularly through the frequent implementation of interactive teaching formats. Discussion Despite some limitations, these findings highlight the prevalence of overconfidence effects in nursing students, the presence of different learning profiles, and the importance of incorporating feedback within interactive learning formats concerning hand hygiene. Accordingly, educators need to be trained and supervised to deliver these learning formats and provide feedback to students effectively.
Published: 2024
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6. Two-Dimensional ICI-ISI Turbo Equalization for Doubly-Dispersive High-Spread Channels.

Author: Jorge A. Pires, Benjamin Belzer, Krishnamoorthy Sivakumar, and Thomas R. Fischer
Published: 2024
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7. Development of the entrustable professional activity ‘medication reconciliation’ for clinical pharmacy

Author: Ula Bozic, Matthias J. Witti, Schmidmaier Ralf, Martin R. Fischer, Jan M. Zottmann, and Yvonne M. Pudritz
Subjects: Entrustable professional activities, Clinical pharmacy services, Pharmacy education, Assessment, Special aspects of education, LC8-6691, Medicine
Abstract: Abstract Background Entrustable professional activities (EPAs) are observable process descriptions of clinical work units. EPAs support learners and tutors in assessment within healthcare settings. For use amongst our pharmacy students as well as pre-registration pharmacists we wanted to develop and validate an EPA for use in a clinical pharmacy setting at LMU University Hospital. Methods The development of the clinical pharmacy EPA followed a set pathway. A rapid literature review informed the first draft, an interprofessional consensus group consisting of pharmacists, nurses, and medical doctors refined this draft. The refined version was then validated via online survey utilising clinical pharmacists from Germany. Results We designed, refined and validated an EPA regarding medication reconciliation for assessment of pharmacy students and trainees within the pharmacy department at LMU University Hospital in Munich. Along with the EPA description an associated checklist to support the entrustment decision was created. For validation an online survey with 27 clinical pharmacists from all over Germany was conducted. Quality testing with the EQual rubric showed a good EPA quality. Conclusions We developed the first clinical pharmacy EPA for use in a German context. Medication reconciliation is a suitable EPA candidate as it describes a clinical activity performed by pharmacists in many clinical settings. The newly developed and validated EPA ‘Medication Reconciliation’ will be used to assess pharmacy students and trainees.
Published: 2024
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8. The relation between learners’ experience in simulations and diagnostic accuracy: Generalizability across medical and teacher education

Author: Olga Chernikova, Matthias Stadler, Daniel Sommerhoff, Christian Schons, Nicole Heitzmann, Doris Holzberger, Tina Seidel, Constanze Richters, Amadeus J. Pickal, Christof Wecker, Michael Nickl, Elias Codreanu, Stefan Ufer, Stephanie Kron, Caroline Corves, Birgit J. Neuhaus, Martin R. Fischer, and Frank Fischer
Subjects: Simulation-based learning, Diagnostic skills, Learners' experience, Higher education, Cross-domain research, Electronic computers. Computer science, QA75.5-76.95, Psychology, BF1-990
Abstract: Simulation-based learning is being increasingly implemented across different domains of higher education to facilitate essential skills and competences (e.g. diagnostic skills, problem-solving, etc.). However, the lack of research that assesses and compares simulations used in different contexts (e.g., from design perspective) makes it challenging to effectively transfer good practices or establish guidelines for effective simulations across different domains. This study suggests some initial steps to address this issue by investigating the relations between learners' experience in simulation-based learning environments and learners' diagnostic accuracy across several different domains and types of simulations, with the goal of facilitating cross-domain research and generalizability. The findings demonstrate that used learners' experience ratings are correlated with objective performance measures, and can be used for meaningful comparisons across different domains. Measures of perceived extraneous cognitive load were found to be specific to the simulation and situation, while perceived involvement and authenticity were not. Further, the negative correlation between perceived extraneous cognitive load and perceived authenticity was more pronounced in interaction-based simulations. These results provide supporting evidence for theoretical models that highlight the connection between learners' experience in simulated learning environments and their performance. Overall, this research contributes to the understanding of the relationship between learners’ experience in simulation-based learning environments and their diagnostic accuracy, paving the way for the dissemination of best practices across different domains within higher education.
Published: 2024
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9. Why did I participate in an HIV vaccine study? Experiences of participation in the first phase II HIV vaccine trial in Mozambique: An ancillary study using a mixed-method approach

Author: Igor P. Ubisse Capitine, Álvaro Marcela Manhiça, Paulo Tembe Júnior, Patrícia M. Ramgi, Sérgio Chicumbe, Arne Kroidl, Martin R. Fischer, and Caroline De Schacht
Subjects: Socio-behavioral research, HIV trials, Motives for participation, Sexual behavior of participants, Research Subjects’ experiences, Health Belief Model, Immunologic diseases. Allergy, RC581-607
Abstract: Introduction: This study recognized the lack of information regarding recruitment and retention factors associated with implementing HIV vaccine trials from the perspective of de facto participants. It aimed to describe the motives and experiences of 31 young adults who participated in a phase II HIV vaccine clinical trial conducted in Maputo, Mozambique. Methods: This was an ancillary study with a mixed-method approach that employed a convergent design, combining both quantitative and qualitative methodologies. Data collection involved questionnaire surveys, in-depth interviews, and focus group discussions. Participants were assessed before and after learning whether they received the experimental vaccine or placebo. Thematic analysis was used for qualitative data, while descriptive analysis and statistical tests such as Fischer’s test and McNemar’s exact test were applied to quantitative data. The study also utilized the Health Belief Model to understand the decision-making process of participating in an HIV vaccine study. Results: Most of our participants were young females, single, with limited financial resources. Participants joined the trial with the belief that they had a unique opportunity to help the fight against HIV and contribute to the research for the discovery of an HIV vaccine. Positive experiences related to trial participation include gaining knowledge about HIV and personal health and receiving risk reduction counseling. Participants reported blood collection as a negative experience and that they suffered social harm because of trial participation. Participants felt abandoned after the trial ended. Conclusion: Preventive HIV vaccine trials should integrate a social-behavioral component to assess reasons for participation and refusal in real-time. Providing ongoing personal attention is crucial for young individuals who have committed 1–2 years to trial participation, extending beyond the trial period. Implementing tailored strategies for HIV risk assessment and reduction during and after the trial is essential. Addressing these factors can enhance preventive HIV vaccine trial implementation.
Published: 2024
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10. Assessment of Erythrocyte Transketolase, Whole Blood Thiamine Diphosphate, and Human Milk Thiamine Concentrations to Identify Infants and Young Children Responding Favorably to Therapeutic Thiamine Administration: Findings from the Lao Thiamine Study, a Prospective Cohort Study

Author: Sonja Y Hess, Taryn J Smith, Charles D Arnold, Kerry S Jones, Daniela Hampel, Laurent Hiffler, Indi Trehan, Philip R Fischer, Sarah R Meadows, Damon A Parkington, Kenneth H Brown, Dalaphone Sitthideth, Xiuping Tan, Albert Koulman, Lindsay H Allen, and Sengchanh Kounnavong
Subjects: erythrocyte transketolase, thiamine diphosphate, thiamine deficiency, thiamine deficiency disorders, thiamine responsive disorders, beriberi, Nutrition. Foods and food supply, TX341-641, Nutritional diseases. Deficiency diseases, RC620-627
Abstract: Background: There is limited information on relationships among biomarkers of thiamine status (whole blood thiamine diphosphate [ThDP], erythrocyte transketolase activity coefficient [ETKac], and human milk thiamine [MTh]) and clinical manifestations of thiamine deficiency. Objectives: This study aimed to explore correlations among these biomarkers and thiamine responsive disorders (TRDs), a diagnosis based on favorable clinical response to thiamine. Methods: Hospitalized infants and young children (aged 21 d to 1.25 were explored using area under the receiver operating characteristic curve framework. Results: Thiamine biomarkers were available for 287 hospitalized children and 228 community children (mean age 4.7 mo; 59.4% male). Median (interquartile range [IQR]) ThDP and ETKac were 66.9 nmol/L (IQR: 41.4, 96.9 nmol/L) and 1.25 nmol/L (IQR: 1.11, 1.48 nmol/L), respectively, among hospitalized children, and 64.1 nmol/L (IQR: 50.0, 85.3 nmol/L) and 1.22 nmol/L (IQR: 1.12, 1.37 nmol/L) among 228 community children (P > 0.05 for both). Forty-five percent of breastfeeding mothers of infants
Published: 2024
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11. Patient-reported outcomes in large vessel vasculitis: insights from a retrospective analysis of disease activity and associated factors

Author: A. Kernder, M. Rohde, H. Acar, C. Düsing, R. Fischer-Betz, I. Haase, J. Mucke, O. Sander, J. G. Richter, T. Filla, M. Schneider, and G. Chehab
Subjects: Patient-reported outcomes (PROs), Disease activity, Giant cell arteritis, Large vessel vasculitis, Takayasu arteriitis, Public aspects of medicine, RA1-1270
Abstract: Abstract Background Patient-reported outcomes (PROs) play a crucial role in assessing rheumatic diseases, offering insights into disease evaluation and treatment efficacy. This study focuses on PRO assessment in large vessel vasculitides, including Takayasu Arteritis and Giant Cell Arteritis (GCA). Methods We retrospectively analyzed routine data from patients treated at our rheumatology clinic over a 10-year span. Patient and physician-rated global disease activity scale (G-DAS) scores, measured on a numeric rating scale (0–10 points), were collected at each visit. Clinical variables like age, sex, body mass index (BMI), disease duration, lab values, pain perception, and questionnaire responses were recorded. Linear regression and generalized additive linear regression (GAM analysis) examined associations between PROs and these factors. Results The study included 138 patients, primarily diagnosed with GCA (94.4%). Mean follow-up was 2.5 years (0-7.7). Patient and physician G-DAS exhibited a moderate correlation (Pearson R 0.19, CI 0.14–0.24, p
Published: 2024
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12. Insights into diagnostic errors in endocrinology: a prospective, case-based, international study

Author: Jessica Frey, Leah T. Braun, Laura Handgriff, Benjamin Kendziora, Martin R. Fischer, Martin Reincke, Laura Zwaan, and Ralf Schmidmaier
Subjects: Clinical reasoning, Diagnostic errors, Endocrinology, Internal medicine, Special aspects of education, LC8-6691, Medicine
Abstract: Abstract Background Diagnostic errors in internal medicine are common. While cognitive errors have previously been identified to be the most common contributor to errors, very little is known about errors in specific fields of internal medicine such as endocrinology. This prospective, multicenter study focused on better understanding the causes of diagnostic errors made by general practitioners and internal specialists in the area of endocrinology. Methods From August 2019 until January 2020, 24 physicians completed five endocrine cases on an online platform that simulated the diagnostic process. After each case, the participants had to state and explain why they chose their assumed diagnosis. The data gathering process as well as the participants’ explanations were quantitatively and qualitatively analyzed to determine the causes of the errors. The diagnostic processes in correctly and incorrectly solved cases were compared. Results Seven different causes of diagnostic error were identified, the most frequent being misidentification (mistaking one diagnosis with a related one or with more frequent and similar diseases) in 23% of the cases. Other causes were faulty context generation (21%) and premature closure (17%). The diagnostic confidence did not differ between correctly and incorrectly solved cases (median 8 out of 10, p = 0.24). However, in incorrectly solved cases, physicians spent less time on the technical findings (such as lab results, imaging) (median 250 s versus 199 s, p
Published: 2023
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13. Comparison and AI-based prediction of graph comprehension skills based on the visual strategies of first-year physics and medicine students

Author: Verena Ruf, Yavuz Dinc, Stefan Küchemann, Markus Berndt, Steffen Steinert, Daniela Kugelmann, Jonathan Bortfeldt, Jörg Schreiber, Martin R. Fischer, and Jochen Kuhn
Subjects: Special aspects of education, LC8-6691, Physics, QC1-999
Abstract: Graphical representations of data are common in many disciplines. Previous research has found that physics students appear to have better graph comprehension skills than students from social science disciplines, regardless of the task context. However, the graph comprehension skills of physics students have not yet been compared with (veterinary) medicine students, both of which are disciplines that require multiple science, technology, engineering, and mathematics (STEM) courses. This study extends previous research on this subject by exploring whether physics majors possess superior graph comprehension skills due to their study discipline. Here, participants solved 24 graph comprehension tasks across various subjects, including mathematics, physics, and medicine; these tests were conducted at the beginning and end of their first semester. Graph comprehension gain was calculated based on the percentage of correct and incorrect answers in the pretest and the post-test. In addition to these comparisons, we replicated previous research that successfully distinguished correct and incorrect solvers based on their visual behavior by using a novel machine-learning method tailored to small datasets. Through this replication of statistical analyses, we aim to ensure the reliability of adaptive learning systems in the future, regardless of data size, using the same machine-learning method. Physics and medical students were found to exhibit relatively similar graph comprehension gain; this is in contrast to previous research comparing physics and non-STEM students. Our results also revealed that both physics and medical students use similar visual strategies to solve these tasks. However, correct and incorrect solvers could be distinguished via machine-learning methods regardless of their discipline. Our research suggests that visual behavior is a good predictor of graph comprehension skills.
Published: 2024
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14. Checkpoint Inhibitor Monotherapy in Potentially Trial-Eligible or Trial-Ineligible Patients With Metastatic NSCLC in the German Prospective CRISP Registry Real-World Cohort (AIO-TRK-0315)

Author: Frank Griesinger, MD, PhD, Wilfried E.E. Eberhardt, MD, PhD, Wolfgang M. Brueckl, MD, PhD, Horst-Dieter Hummel, MD, PhD, Bastian Jaeschke, MD, Jens Kern, MD, Claas Wesseler, MD, Martina Jänicke, PdD, Annette Fleitz, PhD, Stefan Zacharias, PhD, Annette Hipper, PhD, Annika Groth, MD, PhD, Wilko Weichert, MD, PhD, Steffen Dörfel, Volker Petersen, MD, Jan Schröder, MD, Jochen Wilke, MD, Martin Sebastian, MD, Michael Thomas, MD, PhD, Juliana Ababei, Jürgen Alt, Andreas Ammon, Jürgen Anhuf, Ivo Azeh, Stefan Bauer, Dirk Behringer, Winfried Berger, Christiane Bernhardt, Mathias Bertram, Michael Boesche, Sabine Bohnet, Harald-Robert Bruch, Wolfgang Brückl, Ulrike Burkhard-Meier, Petros Christopoulos, Klaus-Ulrich Däßler, Maike de Wit, Tobias Dechow, Reinhard Depenbusch, Lutz Dietze, Markus Dommach, Wilfried Eberhardt, Corinna Elender, Wolfgang Elsel, Till-Oliver Emde, Martin Faehling, Thomas Fietz, Jürgen R. Fischer, Dimitri Flieger, Anke Freidt, Werner Freier, Christian Frenzel, Florian Fuchs, Roswitha Fuchs, Tobias Gaska, Wolfgang Gleiber, Christian Grah, Frank Griesinger, Christian Grohé, Matthias Groschek, Björn Güldenzoph, Andreas Günther, Siegfried Haas, Matthias Hackenthal, Volker Hagen, Lars Hahn, Verena Hannig Carla, Richard Hansen, Hanns-Detlev Harich, Monika Heilmann, Kathrin Heinrich, Christiane Hering-Schubert, Jörg Heßling, Petra Hoffknecht, Patricia Hortig, Gerdt Hübner, Horst-Dieter Hummel, Ulrich Hutzschenreuter, Thomas Illmer, Georg Innig, Bastian Jaeschke, Christian Junghanß, Ulrich Kaiser, Haytham Kamal, Kato Kambartel, Jens Kern, Martin Kimmich, Dorothea Kingreen, Heinz Kirchen, Martine Klausmann, Ortwin Klein, Konrad Kokowski, Wolfgang Körber, Cornelius Kortsik, Dirk Koschel, Benoit Krämer, Beate Krammer-Steiner, Eckart Laack, Christof Lamberti, Rumo David Leistner, Christoph Losem, Andreas Lück, Christoph Maintz, Kerstin Martin, Dirk Medgenberg, Martin Metzenmacher, Christian Meyer zum Büschenfelde, Philipp Meyn, Enno Moorahrend, Annette Müller, Lothar Müller, Michael Neise, Holger Nückel, Arnd Nusch, Tobias Overbeck, Henning Pelz, Volker Petersen, Bettina Peuser, Margarete Plath, Winfried J. Randerath, Jacqueline Rauh, Martin Reck, Dietmar Reichert, Niels Reinmuth, Marcel Reiser, Roland Repp, Daniel Reschke, Achim Rittmeyer, Yolanda Rodemer, Sandra Sackmann, Parvis Sadjadian, Reiner Sandner, Annette Sauer, Harald Schäfer, Christoph Schaudt, Rudolf Schlag, Burkhard Schmidt, Stephan Schmitz, Jan Schröder, Michael Schroeder, Mathias Schulze, Christian Schumann, Wolfgang Schütte, Martin Schwaiblmair, Florian Schwindt Peter, Martin Sebastian, Bernd Seese, Gernot Seipelt, Thomas Sorgenfrei, Johannes Steiff, Heike Steiniger, Tanja Trarbach, Amanda Tufman, Jens Uhlig, Ursula Vehling-Kaiser, Eyck von der Heyde, Ulla von Verschuer, Cornelius Waller, Thomas Wehler, Georg Weißenborn, Florian Weißinger, Martin Wermke, Claas Wesseler, Jörg Wiegand, Stefan Wilhelm, Jochen Wilke, Mark-Oliver Zahn, Matthias Zaiss, and Matthias Zeth
Subjects: Non–small cell lung carcinoma, Prospective studies, Immune checkpoint inhibitors, Pembrolizumab, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract: Introduction: Patients with metastatic NSCLC (mNSCLC) treated with immune checkpoint inhibitors in clinical practice may often not meet the strict inclusion criteria of clinical trials. Our aim was to assess the trial eligibility of patients with mNSCLC treated with pembrolizumab monotherapy in real-world and to compare the outcome of “trial-ineligible” and “potentially trial-eligible” patients. Methods: Data from the prospective, clinical research platform CRISP were used to compare patient characteristics, treatment, and outcome of patients with programmed cell death-ligand 1 tumor proportion score greater than or equal to 50% tumors treated with pembrolizumab monotherapy who are deemed either “potentially trial-eligible” or “trial-ineligible” according to inclusion and exclusion criteria of the registrational studies (KEYNOTE-024 and -042). Results: Of 746 patients included, 343 patients (46.0%) were classified as “trial-ineligible” and had significantly worse outcomes compared with “potentially trial-eligible” patients (n = 403, 54.0%): median progression-free survival: 6.2 (95% confidence interval [CI]: 5.2–8.4) versus 10.3 (95% CI: 8.4–13.8) months, hazard ratio (trial-ineligible versus potentially trial-eligible) of 1.43 (95% CI: 1.19–1.72), p less than 0.001; median overall survival: 15.9 (95% CI: 11.4–20.3) versus 25.3 (95% CI: 19.8–30.4) months, hazard ratio of 1.36 (95% CI: 1.10–1.67), p equals 0.004. Conclusions: Our data reveal that a considerable proportion of patients with mNSCLC are not eligible to participate in a clinical trial and were found to have worse outcomes than potentially trial-eligible patients, whose outcomes were comparable with those obtained from pivotal clinical trials. This is of substantial clinical relevance for physicians discussing outcomes to be expected with their patients and stresses the need for real-world effectiveness analyses.
Published: 2024
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15. Inhibition of HIV-1 release by ADAM metalloproteinase inhibitors

Author: Joanna Ireland, Jason Segura, Genbin Shi, Julianna Buchwald, Gwynne Roth, Thomas Juncheng Shen, Ruipeng Wang, Xinhua Ji, Elizabeth R. Fischer, Susan Moir, Tae-Wook Chun, and Peter D. Sun
Subjects: HIV-1 infection of CD4 T-cells, viral release, L-selectin (CD62L), ADAM metallopeptidase domain, ADAM10 and 17, batimastat (BB-94), Microbiology, QR1-502
Abstract: HIV-1 gp120 glycan binding to C-type lectin adhesion receptor L-selectin/CD62L on CD4 T cells facilitates viral attachment and entry. Paradoxically, the adhesion receptor impedes HIV-1 budding from infected T cells and the viral release requires the shedding of CD62L. To systematically investigate CD62L-shedding mediated viral release and its potential inhibition, we screened compounds specific for serine-, cysteine-, aspartyl-, and Zn-dependent proteases for CD62L shedding inhibition and found that a subclass of Zn-metalloproteinase inhibitors, including BB-94, TAPI, prinomastat, GM6001, and GI25423X, suppressed CD62L shedding. Their inhibition of HIV-1 infections correlated with enzymatic suppression of both ADAM10 and 17 activities and expressions of these ADAMs were transiently induced during the viral infection. These metalloproteinase inhibitors are distinct from the current antiretroviral drug compounds. Using immunogold labeling of CD62L, we observed association between budding HIV-1 virions and CD62L by transmission electron microscope, and the extent of CD62L-tethering of budding virions increased when the receptor shedding is inhibited. Finally, these CD62L shedding inhibitors suppressed the release of HIV-1 virions by CD4 T cells of infected individuals and their virion release inhibitions correlated with their CD62L shedding inhibitions. Our finding reveals a new therapeutic approach targeted at HIV-1 viral release.
Published: 2024
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16. Metal‐Organic Framework Glass as a Functional Filler Enables Enhanced Performance of Solid‐State Polymer Electrolytes for Lithium Metal Batteries

Author: Junwei Ding, Tao Du, Emil H. Thomsen, David Andresen, Mathias R. Fischer, Anders K. Møller, Andreas R. Petersen, Andreas K. Pedersen, Lars R. Jensen, Shiwen Wang, and Morten M. Smedskjaer
Subjects: functional filler, ionic liquid, lithium metal batteries, metal‐organic framework glass, solid‐state polymer electrolyte, Science
Abstract: Abstract Polymers are promising candidates as solid‐state electrolytes due to their performance and processability, but fillers play a critical role in adjusting the polymer network structure and electrochemical, thermal, and mechanical properties. Most fillers studied so far are anisotropic, limiting the possibility of homogeneous ion transport. Here, applying metal‐organic framework (MOF) glass as an isotropic functional filler, solid‐state polyethylene oxide (PEO) electrolytes are prepared. Calorimetric and diffusion kinetics tests show that the MOF glass addition reduces the glass transition temperature of the polymer phase, improving the mobility of the polymer chains, and thereby facilitating lithium (Li) ion transport. By also incorporating the lithium salt and ionic liquid (IL), Li–Li symmetric cell tests of the PEO‐lithium salt‐MOF glass‐IL electrolyte reveal low overpotential, indicating low interfacial impedance. Simulations show that the isotropic structure of the MOF glass facilitates the wettability of the IL by enhancing interfacial interactions, leading to a less confined IL structure that promotes Li‐ion mobility. Finally, the obtained electrolyte is used to construct Li–lithium iron phosphate full batteries that feature high cycle stability and rate capability. This work therefore demonstrates how an isotropic functional filler can be used to enhance the electrochemical performance of solid‐state polymer electrolytes.
Published: 2024
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17. Regional centromere configuration in the fungal pathogens of the Pneumocystis genus

Author: Ousmane H. Cissé, Shelly J. Curran, H. Diego Folco, Yueqin Liu, Lisa Bishop, Honghui Wang, Elizabeth R. Fischer, A. Sally Davis, Christian Combs, Sabrina Thapar, John P. Dekker, Shiv Grewal, Melanie Cushion, Liang Ma, and Joseph A. Kovacs
Subjects: evolution, chromosome segregation, genome organization, genetics, opportunistic fungi, Microbiology, QR1-502
Abstract: ABSTRACT Centromeres are constricted chromosomal regions that are essential for cell division. In eukaryotes, centromeres display a remarkable architectural and genetic diversity. The basis of centromere-accelerated evolution remains elusive. Here, we focused on Pneumocystis species, a group of mammalian-specific fungal pathogens that form a sister taxon with that of the Schizosaccharomyces pombe, an important genetic model for centromere biology research. Methods allowing reliable continuous culture of Pneumocystis species do not currently exist, precluding genetic manipulation. CENP-A, a variant of histone H3, is the epigenetic marker that defines centromeres in most eukaryotes. Using heterologous complementation, we show that the Pneumocystis CENP-A ortholog is functionally equivalent to CENP-ACnp1 of S. pombe. Using organisms from a short-term in vitro culture or infected animal models and chromatin immunoprecipitation (ChIP)-Seq, we identified CENP-A bound regions in two Pneumocystis species that diverged ~35 million years ago. Each species has a unique short regional centromere (
Published: 2024
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18. Characteristics and quality assessment of online mentoring profile texts in academic medical mentoring

Author: Jonathan A. Gernert, Maximilian Warm, Lukas Salvermoser, Nils Krüger, Stephan Bethe, Lorenz Kocheise, Malte von Hake, Charlotte Meyer-Schwickerath, Tanja Graupe, Martin R. Fischer, and Konstantinos Dimitriadis
Subjects: Medical mentoring, Online matching, Online mentoring profiles, Special aspects of education, LC8-6691, Medicine
Abstract: Abstract Background Mentoring is important for a successful career in academic medicine. In online matching processes, profile texts are decisive for the mentor-selection. We aimed to qualitatively characterize mentoring-profile-texts, identify differences in form and content and thus elements that promote selection. Methods In a mixed method study first, quality of texts in 150 selected mentoring profiles was evaluated (10-point Likert scale; 1 = insufficient to 10 = very good). Second, based on a thematic and content analysis approach of profile texts, categories and subcategories were defined. We compared the presence of the assigned categories between the 25% highest ranked profiles with the 25% lowest ranked ones. Finally, additional predefined categories (hot topics) were labelled on the selected texts and their impact on student evaluation was statistically examined. Results Students rated the quality of texts with a mean of 5.89 ± 1.45. 5 main thematic categories, 21 categories and a total of 74 subcategories were identified. Ten subcategories were significantly associated with high- and four with low-rated profiles. The presence of three or more hot topics in texts significantly correlated with a positive evaluation. Conclusion The introduced classification system helps to understand how mentoring profile texts are composed and which aspects are important for choosing a suited mentor.
Published: 2023
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19. Properties of three collagen scaffolds in comparison with native connective tissue: an in-vitro study

Author: Alex Solderer, Nicole Widmer, Andrea Gubler, Kai R. Fischer, Stefan P. Hicklin, and Patrick R. Schmidlin
Subjects: Collagen matrix, Acellular dermal matrix, Connective tissue graft, Resorption rate, Scanning electron microscope (SEM), Artificial saliva, Medicine, Dentistry, RK1-715
Abstract: Abstract Purpose To evaluate collagen scaffolds (CS) in terms of their in vitro resorption behavior, surface structure, swelling behavior, and mechanical properties in physiologically simulated environments, compared with porcine native connective tissue. Materials and methods Three test materials—one porcine collagen matrix (p-CM), two acellular dermal matrices (porcine = p-ADM, allogenic = a-ADM)—and porcine native connective tissue (p-CTG) as a control material were examined for resorption in four solutions using a high-precision scale. The solutions were artificial saliva (AS) and simulated body fluid (SBF), both with and without collagenase (0.5 U/ml at 37 °C). In addition, the surface structures of CS were analyzed using a scanning electron microscope (SEM) before and after exposure to AS or SBF. The swelling behavior of CS was evaluated by measuring volume change and liquid absorption capacity in phosphate-buffered saline (PBS). Finally, the mechanical properties of CS and p-CTG were investigated using cyclic compression testing in PBS. Results Solutions containing collagenase demonstrated high resorption rates with significant differences (p a-ADM > p-ADM. P-CM exhibited higher elastic properties than p-ADM, whereas a-ADM, like p-CTG, were barely compressible and lost structural integrity under increasing pressure. Conclusions and clinical implications Collagen scaffolds vary significantly in their physical properties, such as resorption and swelling behavior and elastic properties, depending on their microstructure and composition. When clinically applied, these differences should be taken into consideration to achieve the desired outcomes. Graphical Abstract
Published: 2023
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20. SARS-CoV-2 infection of human lung epithelial cells induces TMPRSS-mediated acute fibrin deposition

Author: Rachel Erickson, Chang Huang, Cameron Allen, Joanna Ireland, Gwynne Roth, Zhongcheng Zou, Jinghua Lu, Bernard A. P. Lafont, Nicole L. Garza, Beniah Brumbaugh, Ming Zhao, Motoshi Suzuki, Lisa Olano, Joseph Brzostowski, Elizabeth R. Fischer, Homer L. Twigg, Reed F. Johnson, and Peter D. Sun
Subjects: Science
Abstract: Abstract Severe COVID-associated lung injury is a major confounding factor of hospitalizations and death with no effective treatments. Here, we describe a non-classical fibrin clotting mechanism mediated by SARS-CoV-2 infected primary lung but not other susceptible epithelial cells. This infection-induced fibrin formation is observed in all variants of SARS-CoV-2 infections, and requires thrombin but is independent of tissue factor and other classical plasma coagulation factors. While prothrombin and fibrinogen levels are elevated in acute COVID BALF samples, fibrin clotting occurs only with the presence of viral infected but not uninfected lung epithelial cells. We suggest a viral-induced coagulation mechanism, in which prothrombin is activated by infection-induced transmembrane serine proteases, such as ST14 and TMPRSS11D, on NHBE cells. Our finding reveals the inefficiency of current plasma targeted anticoagulation therapy and suggests the need to develop a viral-induced ARDS animal model for treating respiratory airways with thrombin inhibitors.
Published: 2023
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21. Teaching Optical Principles in XR.

Author: Tobias Zengerle, David A. Plecher, Salome Flegr, Jochen Kuhn, and Martin R. Fischer
Published: 2023
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22. Detection of SARS-CoV-2 IgG antibodies and inflammatory cytokines in saliva-a pilot study

Author: S. Wadhwa, A.J. Yoon, K. Kister, I. Bolin, N. Chintalapudi, A. Besmer, A. Cantos, J. Shah, S.K. Gaitonde, S.W. Granger, C. Bryce, R. Fischer, S.B. Eisig, and M.T. Yin
Subjects: COVID-19, Saliva, Coronavirus, Inflammation, Oral-systemic disease(s), Xerostomia, Dentistry, RK1-715
Abstract: Objective: The pandemic caused by SARS-CoV-2 virus continues to have a profound effect worldwide. However, COVID-19 induced oral facial manifestations have not been fully described. We conducted a prospective study to demonstrate feasibility of anti–SARS-CoV-2 IgG and inflammatory cytokine detection in saliva. Our primary objective was to determine whether COVID-19 PCR positive patients with xerostomia or loss of taste had altered serum or saliva cytokine levels compared to COVID-19 PCR positive patients without those oral symptoms. Our secondary objective was to determine the correlation between serum and saliva COVID-19 antibody levels. Materials and methods: For cytokine analysis, saliva and serum were obtained from 17 participants with PCR-confirmed COVID-19 infection at three sequential time points, yielding 48 saliva samples and 19 paired saliva-serum samples from 14 of the 17 patients. For COVID-19 antibody analyses, an additional 27 paired saliva-serum samples from 22 patients were purchased. Results: The saliva antibody assay had 88.64% sensitivity [95% Confidence Interval (CI) 75.44%, 96.21%] to detect SARS-CoV-2 IgG antibodies compared to serum antibody. Among the inflammatory cytokines assessed - IL-6, TNF-α, IFN-γ, IL-10, IL-12p70, IL-1β, IL-8, IL-13, IL-2, IL-5, IL-7 and IL-17A, xerostomia correlated with lower levels of saliva IL-2 and TNF-α, and elevated levels of serum IL-12p70 and IL-10 (p
Published: 2023
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23. FINCA – a conceptual framework to improve interprofessional collaboration in health education and care

Author: Matthias J. Witti, Jan M. Zottmann, Birgit Wershofen, Jill E. Thistlethwaite, Frank Fischer, and Martin R. Fischer
Subjects: interprofessional education, interprofessional collaboration, collaborative problem-solving skills, observable collaborative activities, learning, teaching, Medicine (General), R5-920
Abstract: The health care system in Germany and in many other countries is facing fundamental challenges due to demographic change, which require new integrated care concepts and a revision of the collaboration between health care professions in everyday clinical practice. Internationally, several competency framework models have been proposed, but a framework that explicitly conceptualizes collaborative activities to improve interprofessional problem-solving competency in health care is still missing. Such a framework should define contextual, person-related, process-related, and outcome-related variables relevant to interprofessional problem solving in health care. Against this background, we present a conceptual framework to improve interprofessional collaboration in health education and care (FINCA) developed with scientific consideration of empirical data and various theoretical references. FINCA reflects an interprofessional learning and interaction process involving two persons from different health care professions and with different individual learning prerequisites. These two initially identify a problem that is likely to require interprofessional collaboration at some point. FINCA acknowledges the context of interprofessional learning, teaching, and working as well as its action-modifying context factors. We follow the reasoning that individual learning prerequisites interact with the teaching context during learning activities. At the heart of FINCA are observable collaborative activities (information sharing and grounding; negotiating; regulating; executing interprofessional activities; maintaining communication) that can be used to assess individuals’ cognitive and social skills. Eventually, the framework envisages an assessment of the outcomes of interprofessional education and collaboration. The proposed conceptual framework provides the basis for analysis and empirical testing of the components and variables it describes and their interactions across studies, educational interventions, and action-modifying contexts. FINCA further provides the basis for fostering the teaching and learning of interprofessional problem-solving skills in various health care settings. It can support faculty and curriculum developers to systematize the implementation and improvement of interprofessional teaching and learning opportunities. From a practical perspective, FINCA can help to better align curricula for different health professions in the future. In principle, we also see potential for transferability of the framework to other areas where different professions collaborate.
Published: 2023
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24. Erratum: Measurement of prompt and nonprompt charmonium suppression in PbPb collisions at 5.02 TeV

Author: A. M. Sirunyan, A. Tumasyan, W. Adam, F. Ambrogi, E. Asilar, T. Bergauer, J. Brandstetter, E. Brondolin, M. Dragicevic, J. Erö, A. Escalante Del Valle, M. Flechl, M. Friedl, R. Frühwirth, V. M. Ghete, J. Grossmann, J. Hrubec, M. Jeitler, A. König, N. Krammer, I. Krätschmer, D. Liko, T. Madlener, I. Mikulec, E. Pree, N. Rad, H. Rohringer, J. Schieck, R. Schöfbeck, M. Spanring, D. Spitzbart, W. Waltenberger, J. Wittmann, C.-E. Wulz, M. Zarucki, V. Chekhovsky, V. Mossolov, J. Suarez Gonzalez, E. A. De Wolf, D. Di Croce, X. Janssen, J. Lauwers, M. Van De Klundert, H. Van Haevermaet, P. Van Mechelen, N. Van Remortel, S. Abu Zeid, F. Blekman, J. D’Hondt, I. De Bruyn, J. De Clercq, K. Deroover, G. Flouris, D. Lontkovskyi, S. Lowette, I. Marchesini, S. Moortgat, L. Moreels, Q. Python, K. Skovpen, S. Tavernier, W. Van Doninck, P. Van Mulders, I. Van Parijs, D. Beghin, B. Bilin, H. Brun, B. Clerbaux, G. De Lentdecker, H. Delannoy, B. Dorney, G. Fasanella, L. Favart, R. Goldouzian, A. Grebenyuk, A. K. Kalsi, T. Lenzi, J. Luetic, T. Maerschalk, A. Marinov, T. Seva, E. Starling, C. Vander Velde, P. Vanlaer, D. Vannerom, R. Yonamine, F. Zenoni, T. Cornelis, D. Dobur, A. Fagot, M. Gul, I. Khvastunov, D. Poyraz, C. Roskas, S. Salva, M. Tytgat, W. Verbeke, N. Zaganidis, H. Bakhshiansohi, O. Bondu, S. Brochet, G. Bruno, C. Caputo, A. Caudron, P. David, S. De Visscher, C. Delaere, M. Delcourt, B. Francois, A. Giammanco, M. Komm, G. Krintiras, V. Lemaitre, A. Magitteri, A. Mertens, M. Musich, K. Piotrzkowski, L. Quertenmont, A. Saggio, M. Vidal Marono, S. Wertz, J. Zobec, W. L. Aldá Júnior, F. L. Alves, G. A. Alves, L. Brito, M. Correa Martins Junior, C. Hensel, A. Moraes, M. E. Pol, P. Rebello Teles, E. Belchior Batista Das Chagas, W. Carvalho, J. Chinellato, E. Coelho, E. M. Da Costa, G. G. Da Silveira, D. De Jesus Damiao, S. Fonseca De Souza, L. M. Huertas Guativa, H. Malbouisson, M. Melo De Almeida, C. Mora Herrera, L. Mundim, H. Nogima, L. J. Sanchez Rosas, A. Santoro, A. Sznajder, M. Thiel, E. J. Tonelli Manganote, F. Torres Da Silva De Araujo, A. Vilela Pereira, S. Ahuja, C. A. Bernardes, T. R. Fernandez Perez Tomei, E. M. Gregores, P. G. Mercadante, S. F. Novaes, Sandra S. Padula, D. Romero Abad, J. C. Ruiz Vargas, A. Aleksandrov, R. Hadjiiska, P. Iaydjiev, M. Misheva, M. Rodozov, M. Shopova, G. Sultanov, A. Dimitrov, L. Litov, B. Pavlov, P. Petkov, W. Fang, X. Gao, L. Yuan, M. Ahmad, J. G. Bian, G. M. Chen, H. S. Chen, M. Chen, Y. Chen, C. H. Jiang, D. Leggat, H. Liao, Z. Liu, F. Romeo, S. M. Shaheen, A. Spiezia, J. Tao, C. Wang, Z. Wang, E. Yazgan, H. Zhang, S. Zhang, J. Zhao, Y. Ban, G. Chen, J. Li, Q. Li, S. Liu, Y. Mao, S. J. Qian, D. Wang, Z. Xu, F. Zhang, Y. Wang, C. Avila, A. Cabrera, C. A. Carrillo Montoya, L. F. Chaparro Sierra, C. Florez, C. F. González Hernández, J. D. Ruiz Alvarez, M. A. Segura Delgado, B. Courbon, N. Godinovic, D. Lelas, I. Puljak, P. M. Ribeiro Cipriano, T. Sculac, Z. Antunovic, M. Kovac, V. Brigljevic, D. Ferencek, K. Kadija, B. Mesic, A. Starodumov, T. Susa, M. W. Ather, A. Attikis, G. Mavromanolakis, J. Mousa, C. Nicolaou, F. Ptochos, P. A. Razis, H. Rykaczewski, M. Finger, E. Carrera Jarrin, M. A. Mahmoud, Y. Mohammed, E. Salama, R. K. Dewanjee, M. Kadastik, L. Perrini, M. Raidal, A. Tiko, C. Veelken, P. Eerola, H. Kirschenmann, J. Pekkanen, M. Voutilainen, J. Havukainen, J. K. Heikkilä, T. Järvinen, V. Karimäki, R. Kinnunen, T. Lampén, K. Lassila-Perini, S. Laurila, S. Lehti, T. Lindén, P. Luukka, H. Siikonen, E. Tuominen, J. Tuominiemi, T. Tuuva, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, J. L. Faure, F. Ferri, S. Ganjour, S. Ghosh, P. Gras, G. Hamel de Monchenault, P. Jarry, I. Kucher, C. Leloup, E. Locci, M. Machet, J. Malcles, G. Negro, J. Rander, A. Rosowsky, M.Ö. Sahin, M. Titov, A. Abdulsalam, C. Amendola, I. Antropov, S. Baffioni, F. Beaudette, P. Busson, L. Cadamuro, C. Charlot, R. Granier de Cassagnac, M. Jo, S. Lisniak, A. Lobanov, J. Martin Blanco, M. Nguyen, C. Ochando, G. Ortona, P. Paganini, P. Pigard, R. Salerno, J. B. Sauvan, Y. Sirois, A. G. Stahl Leiton, T. Strebler, Y. Yilmaz, A. Zabi, A. Zghiche, J.-L. Agram, J. Andrea, D. Bloch, J.-M. Brom, M. Buttignol, E. C. Chabert, N. Chanon, C. Collard, E. Conte, X. Coubez, J.-C. Fontaine, D. Gelé, U. Goerlach, M. Jansová, A.-C. Le Bihan, N. Tonon, P. Van Hove, S. Gadrat, S. Beauceron, C. Bernet, G. Boudoul, R. Chierici, D. Contardo, P. Depasse, H. El Mamouni, J. Fay, L. Finco, S. Gascon, M. Gouzevitch, G. Grenier, B. Ille, F. Lagarde, I. B. Laktineh, M. Lethuillier, L. Mirabito, A. L. Pequegnot, S. Perries, A. Popov, V. Sordini, M. Vander Donckt, S. Viret, T. Toriashvili, Z. Tsamalaidze, C. Autermann, L. Feld, M. K. Kiesel, K. Klein, M. Lipinski, M. Preuten, C. Schomakers, J. Schulz, M. Teroerde, V. Zhukov, A. Albert, E. Dietz-Laursonn, D. Duchardt, M. Endres, M. Erdmann, S. Erdweg, T. Esch, R. Fischer, A. Güth, M. Hamer, T. Hebbeker, C. Heidemann, K. Hoepfner, S. Knutzen, M. Merschmeyer, A. Meyer, P. Millet, S. Mukherjee, T. Pook, M. Radziej, H. Reithler, M. Rieger, F. Scheuch, D. Teyssier, S. Thüer, G. Flügge, B. Kargoll, T. Kress, A. Künsken, T. Müller, A. Nehrkorn, A. Nowack, C. Pistone, O. Pooth, A. Stahl, M. Aldaya Martin, T. Arndt, C. Asawatangtrakuldee, K. Beernaert, O. Behnke, U. Behrens, A. Bermúdez Martínez, A. A. Bin Anuar, K. Borras, V. Botta, A. Campbell, P. Connor, C. Contreras-Campana, F. Costanza, C. Diez Pardos, G. Eckerlin, D. Eckstein, T. Eichhorn, E. Eren, E. Gallo, J. Garay Garcia, A. Geiser, J. M. Grados Luyando, A. Grohsjean, P. Gunnellini, M. Guthoff, A. Harb, J. Hauk, M. Hempel, H. Jung, M. Kasemann, J. Keaveney, C. Kleinwort, I. Korol, D. Krücker, W. Lange, A. Lelek, T. Lenz, J. Leonard, K. Lipka, W. Lohmann, R. Mankel, I.-A. Melzer-Pellmann, A. B. Meyer, G. Mittag, J. Mnich, A. Mussgiller, E. Ntomari, D. Pitzl, A. Raspereza, M. Savitskyi, P. Saxena, R. Shevchenko, N. Stefaniuk, G. P. Van Onsem, R. Walsh, Y. Wen, K. Wichmann, C. Wissing, O. Zenaiev, R. Aggleton, S. Bein, V. Blobel, M. Centis Vignali, T. Dreyer, E. Garutti, D. Gonzalez, J. Haller, A. Hinzmann, M. Hoffmann, A. Karavdina, R. Klanner, R. Kogler, N. Kovalchuk, S. Kurz, T. Lapsien, D. Marconi, M. Meyer, M. Niedziela, D. Nowatschin, F. Pantaleo, T. Peiffer, A. Perieanu, C. Scharf, P. Schleper, A. Schmidt, S. Schumann, J. Schwandt, J. Sonneveld, H. Stadie, G. Steinbrück, F. M. Stober, M. Stöver, H. Tholen, D. Troendle, E. Usai, A. Vanhoefer, B. Vormwald, M. Akbiyik, C. Barth, M. Baselga, S. Baur, E. Butz, R. Caspart, T. Chwalek, F. Colombo, W. De Boer, A. Dierlamm, N. Faltermann, B. Freund, R. Friese, M. Giffels, M. A. Harrendorf, F. Hartmann, S. M. Heindl, U. Husemann, F. Kassel, S. Kudella, H. Mildner, M. U. Mozer, Th. Müller, M. Plagge, G. Quast, K. Rabbertz, M. Schröder, I. Shvetsov, G. Sieber, H. J. Simonis, R. Ulrich, S. Wayand, M. Weber, T. Weiler, S. Williamson, C. Wöhrmann, R. Wolf, G. Anagnostou, G. Daskalakis, T. Geralis, A. Kyriakis, D. Loukas, I. Topsis-Giotis, G. Karathanasis, S. Kesisoglou, A. Panagiotou, N. Saoulidou, K. Kousouris, I. Evangelou, C. Foudas, P. Gianneios, P. Katsoulis, P. Kokkas, S. Mallios, N. Manthos, I. Papadopoulos, E. Paradas, J. Strologas, F. A. Triantis, D. Tsitsonis, M. Csanad, N. Filipovic, G. Pasztor, O. Surányi, G. I. Veres, G. Bencze, C. Hajdu, D. Horvath, Á. Hunyadi, F. Sikler, V. Veszpremi, N. Beni, S. Czellar, J. Karancsi, A. Makovec, J. Molnar, Z. Szillasi, M. Bartók, P. Raics, Z. L. Trocsanyi, B. Ujvari, S. Choudhury, J. R. Komaragiri, S. Bahinipati, S. Bhowmik, P. Mal, K. Mandal, A. Nayak, D. K. Sahoo, N. Sahoo, S. K. Swain, S. Bansal, S. B. Beri, V. Bhatnagar, R. Chawla, N. Dhingra, A. Kaur, M. Kaur, S. Kaur, R. Kumar, P. Kumari, A. Mehta, J. B. Singh, G. Walia, Ashok Kumar, Aashaq Shah, A. Bhardwaj, S. Chauhan, B. C. Choudhary, R. B. Garg, S. Keshri, A. Kumar, S. Malhotra, M. Naimuddin, K. Ranjan, R. Sharma, R. Bhardwaj, R. Bhattacharya, S. Bhattacharya, U. Bhawandeep, S. Dey, S. Dutt, S. Dutta, N. Majumdar, A. Modak, K. Mondal, S. Mukhopadhyay, S. Nandan, A. Purohit, A. Roy, S. Roy Chowdhury, S. Sarkar, M. Sharan, S. Thakur, P. K. Behera, R. Chudasama, D. Dutta, V. Jha, V. Kumar, A. K. Mohanty, P. K. Netrakanti, L. M. Pant, P. Shukla, A. Topkar, T. Aziz, S. Dugad, B. Mahakud, S. Mitra, G. B. Mohanty, N. Sur, B. Sutar, S. Banerjee, S. Chatterjee, P. Das, M. Guchait, Sa. Jain, S. Kumar, M. Maity, G. Majumder, K. Mazumdar, T. Sarkar, N. Wickramage, S. Dube, V. Hegde, A. Kapoor, K. Kothekar, S. Pandey, A. Rane, S. Sharma, S. Chenarani, E. Eskandari Tadavani, S. M. Etesami, M. Khakzad, M. Mohammadi Najafabadi, M. Naseri, S. Paktinat Mehdiabadi, F. Rezaei Hosseinabadi, B. Safarzadeh, M. Zeinali, M. Felcini, M. Grunewald, M. Abbrescia, C. Calabria, A. Colaleo, D. Creanza, L. Cristella, N. De Filippis, M. De Palma, F. Errico, L. Fiore, G. Iaselli, S. Lezki, G. Maggi, M. Maggi, G. Miniello, S. My, S. Nuzzo, A. Pompili, G. Pugliese, R. Radogna, A. Ranieri, G. Selvaggi, A. Sharma, L. Silvestris, R. Venditti, P. Verwilligen, G. Abbiendi, C. Battilana, D. Bonacorsi, L. Borgonovi, S. Braibant-Giacomelli, R. Campanini, P. Capiluppi, A. Castro, F. R. Cavallo, S. S. Chhibra, G. Codispoti, M. Cuffiani, G. M. Dallavalle, F. Fabbri, A. Fanfani, D. Fasanella, P. Giacomelli, C. Grandi, L. Guiducci, S. Marcellini, G. Masetti, A. Montanari, F. L. Navarria, A. Perrotta, A. M. Rossi, T. Rovelli, G. P. Siroli, N. Tosi, S. Albergo, S. Costa, A. Di Mattia, F. Giordano, R. Potenza, A. Tricomi, C. Tuve, G. Barbagli, K. Chatterjee, V. Ciulli, C. Civinini, R. D’Alessandro, E. Focardi, P. Lenzi, M. Meschini, S. Paoletti, L. Russo, G. Sguazzoni, D. Strom, L. Viliani, L. Benussi, S. Bianco, D. Piccolo, F. Primavera, V. Calvelli, F. Ferro, F. Ravera, E. Robutti, S. Tosi, A. Benaglia, A. Beschi, L. Brianza, F. Brivio, V. Ciriolo, M. E. Dinardo, S. Fiorendi, S. Gennai, A. Ghezzi, P. Govoni, M. Malberti, S. Malvezzi, R. A. Manzoni, D. Menasce, L. Moroni, M. Paganoni, K. Pauwels, D. 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Liu, W. Luo, B. L. Winer, H. W. Wulsin, S. Cooperstein, O. Driga, P. Elmer, J. Hardenbrook, P. Hebda, S. Higginbotham, A. Kalogeropoulos, D. Lange, J. Luo, D. Marlow, K. Mei, I. Ojalvo, J. Olsen, C. Palmer, P. Piroué, D. Stickland, C. Tully, S. Norberg, A. Barker, V. E. Barnes, S. Das, S. Folgueras, L. Gutay, M. K. Jha, M. Jones, A. W. Jung, A. Khatiwada, D. H. Miller, N. Neumeister, C. C. Peng, H. Qiu, J. F. Schulte, J. Sun, F. Wang, R. Xiao, W. Xie, T. Cheng, N. Parashar, J. Stupak, Z. Chen, K. M. Ecklund, S. Freed, F. J. M. Geurts, M. Guilbaud, M. Kilpatrick, B. Michlin, B. P. Padley, J. Roberts, J. Rorie, W. Shi, Z. Tu, J. Zabel, A. Zhang, A. Bodek, P. de Barbaro, R. Demina, Y. t. Duh, T. Ferbel, M. Galanti, A. Garcia-Bellido, J. Han, O. Hindrichs, A. Khukhunaishvili, K. H. Lo, P. Tan, M. Verzetti, R. Ciesielski, K. Goulianos, C. Mesropian, A. Agapitos, J. P. Chou, Y. Gershtein, T. A. Gómez Espinosa, E. Halkiadakis, M. Heindl, E. Hughes, S. Kaplan, R. Kunnawalkam Elayavalli, S. Kyriacou, A. Lath, R. Montalvo, K. Nash, M. Osherson, H. Saka, S. Salur, S. Schnetzer, D. Sheffield, S. Somalwar, R. Stone, S. Thomas, P. Thomassen, M. Walker, A. G. Delannoy, J. Heideman, G. Riley, K. Rose, S. Spanier, K. Thapa, O. Bouhali, A. Castaneda Hernandez, A. Celik, M. Dalchenko, M. De Mattia, A. Delgado, S. Dildick, R. Eusebi, J. Gilmore, T. Huang, T. Kamon, R. Mueller, Y. Pakhotin, R. Patel, A. Perloff, L. Perniè, D. Rathjens, A. Safonov, A. Tatarinov, K. A. Ulmer, N. Akchurin, J. Damgov, F. De Guio, P. R. Dudero, J. Faulkner, E. Gurpinar, S. Kunori, K. Lamichhane, T. Libeiro, T. Mengke, S. Muthumuni, T. Peltola, S. Undleeb, I. Volobouev, S. Greene, A. Gurrola, R. Janjam, W. Johns, C. Maguire, A. Melo, H. Ni, K. Padeken, P. Sheldon, S. Tuo, J. Velkovska, Q. Xu, M. W. Arenton, P. Barria, B. Cox, R. Hirosky, M. Joyce, A. Ledovskoy, H. Li, C. Neu, T. Sinthuprasith, E. Wolfe, F. Xia, R. Harr, P. E. Karchin, N. Poudyal, J. Sturdy, P. Thapa, S. Zaleski, M. Brodski, J. Buchanan, C. Caillol, S. Dasu, L. Dodd, S. Duric, B. Gomber, M. Grothe, M. Herndon, A. Hervé, U. Hussain, P. Klabbers, A. Lanaro, A. Levine, K. Long, R. Loveless, T. Ruggles, A. Savin, N. Smith, W. H. Smith, D. Taylor, N. Woods, and CMS Collaboration
Subjects: Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Published: 2023
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25. Host-microbe co-metabolism via MCAD generates circulating metabolites including hippuric acid

Author: Kali M. Pruss, Haoqing Chen, Yuanyuan Liu, William Van Treuren, Steven K. Higginbottom, John B. Jarman, Curt R. Fischer, Justin Mak, Beverly Wong, Tina M. Cowan, Michael A. Fischbach, Justin L. Sonnenburg, and Dylan Dodd
Subjects: Science
Abstract: Here, using a mouse model, the authors report a previously undescribed role for medium-chain acyl-CoA dehydrogenase in host metabolism of gut microbiota metabolites, and show that circulating compounds, including the abundant organic acid hippurate, depend on host-microbe co-metabolism of phenylalanine by Clostridium sporogenes.
Published: 2023
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26. Who is on the right track? Behavior-based prediction of diagnostic success in a collaborative diagnostic reasoning simulation

Author: Constanze Richters, Matthias Stadler, Anika Radkowitsch, Ralf Schmidmaier, Martin R. Fischer, and Frank Fischer
Subjects: Simulations, Collaborative diagnostic reasoning processes, Learning process analysis, Medical education, Logfile analysis, Supervised machine learning, Education (General), L7-991
Abstract: Abstract Background Making accurate diagnoses in teams requires complex collaborative diagnostic reasoning skills, which require extensive training. In this study, we investigated broad content-independent behavioral indicators of diagnostic accuracy and checked whether and how quickly diagnostic accuracy could be predicted from these behavioral indicators when they were displayed in a collaborative diagnostic reasoning simulation. Methods A total of 73 medical students and 25 physicians were asked to diagnose patient cases in a medical training simulation with the help of an agent-based radiologist. Log files were automatically coded for collaborative diagnostic activities (CDAs; i.e., evidence generation, sharing and eliciting of evidence and hypotheses, drawing conclusions). These codes were transformed into bigrams that contained information about the time spent on and transitions between CDAs. Support vector machines with linear kernels, random forests, and gradient boosting machines were trained to classify whether a diagnostician could provide the correct diagnosis on the basis of the CDAs. Results All algorithms performed well in predicting diagnostic accuracy in the training and testing phases. Yet, the random forest was selected as the final model because of its better performance (kappa = .40) in the testing phase. The model predicted diagnostic success with higher precision than it predicted diagnostic failure (sensitivity = .90; specificity = .46). A reliable prediction of diagnostic success was possible after about two thirds of the median time spent on the diagnostic task. Most important for the prediction of diagnostic accuracy was the time spent on certain individual activities, such as evidence generation (typical for accurate diagnoses), and collaborative activities, such as sharing and eliciting evidence (typical for inaccurate diagnoses). Conclusions This study advances the understanding of differences in the collaborative diagnostic reasoning processes of successful and unsuccessful diagnosticians. Taking time to generate evidence at the beginning of the diagnostic task can help build an initial adequate representation of the diagnostic case that prestructures subsequent collaborative activities and is crucial for making accurate diagnoses. This information could be used to provide adaptive process-based feedback on whether learners are on the right diagnostic track. Moreover, early instructional support in a diagnostic training task might help diagnosticians improve such individual diagnostic activities and prepare for effective collaboration. In addition, the ability to identify successful diagnosticians even before task completion might help adjust task difficulty to learners in real time.
Published: 2023
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27. Bone envelope for implant placement after alveolar ridge preservation: a systematic review and meta-analysis

Author: Kai R. Fischer, Alex Solderer, Kristina Arlt, Christian Heumann, Chun Ching Liu, and Patrick R. Schmidlin
Subjects: Alveolar ridge preservation, Socket healing, Deproteinized bovine bone mineral (DBBM), Dental implant, Guided bone regeneration (GBR), Extraction socket, Medicine, Dentistry, RK1-715
Abstract: Abstract Purpose To assess the dimensional establishment of a bony envelope after alveolar ridge preservation (ARP) with deproteinized bovine bone mineral (DBBM) in order to estimate the surgical feasibility of standard diameter implants placement without any additional augmentation methods. Methods PubMed, Embase and CENTRAL databases were searched for suitable titles and abstracts using PICO elements. Inclusion criteria were as follows: randomized controlled trials (RCTs) comprising at least ten systemically healthy patients; test groups comprised placement of (collagenated) DBBM w/o membrane and control groups of no grafting, respectively. Selected abstracts were checked regarding their suitability, followed by full-text screening and subsequent statistical data analysis. Probabilities and number needed to treat (NNT) for implant placement without any further need of bone graft were calculated. Results The initial database search identified 2583 studies. Finally, nine studies with a total of 177 implants placed after ARP with DBBM and 130 implants after SH were included for the quantitative and qualitative evaluation. A mean difference of 1.13 mm in ridge width in favour of ARP with DBBM could be calculated throughout all included studies (95% CI 0.28–1.98, t2 = 1–1063, I2 = 68.0%, p
Published: 2022
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28. Erratum to: Searches for long-lived charged particles in pp collisions at s $$ \sqrt{\textrm{s}} $$ = 7 and 8 TeV

Author: The CMS collaboration, S. Chatrchyan, V. Khachatryan, A. M. Sirunyan, A. Tumasyan, W. Adam, T. Bergauer, M. Dragicevic, J. Erö, C. Fabjan, M. Friedl, R. Frühwirth, V. M. Ghete, N. Hörmann, J. Hrubec, M. Jeitler, W. Kiesenhofer, V. Knünz, M. Krammer, I. Krätschmer, D. Liko, I. Mikulec, D. Rabady, B. Rahbaran, C. Rohringer, H. Rohringer, R. Schöfbeck, J. Strauss, A. Taurok, W. Treberer-Treberspurg, W. Waltenberger, C.-E. Wulz, V. Mossolov, N. Shumeiko, J. Suarez Gonzalez, S. Alderweireldt, M. Bansal, S. Bansal, T. Cornelis, E. A. De Wolf, X. Janssen, A. Knutsson, S. Luyckx, L. Mucibello, S. Ochesanu, B. Roland, R. Rougny, H. Van Haevermaet, P. Van Mechelen, N. Van Remortel, A. Van Spilbeeck, F. Blekman, S. Blyweert, J. D’Hondt, A. Kalogeropoulos, J. Keaveney, M. Maes, A. Olbrechts, S. Tavernier, W. Van Doninck, P. Van Mulders, G. P. Van Onsem, I. Villella, B. Clerbaux, G. De Lentdecker, L. Favart, A. P. R. Gay, T. Hreus, A. Léonard, P. E. Marage, A. Mohammadi, L. Perniè, T. Reis, T. Seva, L. Thomas, C. Vander Velde, P. Vanlaer, J. Wang, V. Adler, K. Beernaert, L. Benucci, A. Cimmino, S. Costantini, S. Dildick, G. Garcia, B. Klein, J. Lellouch, A. Marinov, J. Mccartin, A. A. Ocampo Rios, D. Ryckbosch, M. Sigamani, N. Strobbe, F. Thyssen, M. Tytgat, S. Walsh, E. Yazgan, N. Zaganidis, S. Basegmez, C. Beluffi, G. Bruno, R. Castello, A. Caudron, L. Ceard, C. Delaere, T. du Pree, D. Favart, L. Forthomme, A. Giammanco, J. Hollar, P. Jez, V. Lemaitre, J. Liao, O. Militaru, C. Nuttens, D. Pagano, A. Pin, K. Piotrzkowski, A. Popov, M. Selvaggi, J. M. Vizan Garcia, N. Beliy, T. Caebergs, E. Daubie, G. H. Hammad, G. A. Alves, M. Correa Martins Junior, T. Martins, M. E. Pol, M. H. G. Souza, W. L. Aldá Júnior, W. Carvalho, J. Chinellato, A. Custódio, E. M. Da Costa, D. De Jesus Damiao, C. De Oliveira Martins, S. Fonseca De Souza, H. Malbouisson, M. Malek, D. Matos Figueiredo, L. Mundim, H. Nogima, W. L. Prado Da Silva, A. Santoro, A. Sznajder, E. J. Tonelli Manganote, A. Vilela Pereira, C. A. Bernardes, F. A. Dias, T. R. Fernandez Perez Tomei, E. M. Gregores, C. Lagana, F. Marinho, P. G. Mercadante, S. F. Novaes, Sandra S. Padula, V. Genchev, P. Iaydjiev, S. Piperov, M. Rodozov, G. Sultanov, M. Vutova, A. Dimitrov, R. Hadjiiska, V. Kozhuharov, L. Litov, B. Pavlov, P. Petkov, J. G. Bian, G. M. Chen, H. S. Chen, C. H. Jiang, D. Liang, S. Liang, X. Meng, J. Tao, X. Wang, Z. Wang, H. Xiao, M. Xu, C. Asawatangtrakuldee, Y. Ban, Y. Guo, W. Li, S. Liu, Y. Mao, S. J. Qian, H. Teng, D. Wang, L. Zhang, W. Zou, C. Avila, C. A. Carrillo Montoya, J. P. Gomez, B. Gomez Moreno, J. C. Sanabria, N. Godinovic, D. Lelas, R. Plestina, D. Polic, I. Puljak, Z. Antunovic, M. Kovac, V. Brigljevic, S. Duric, K. Kadija, J. Luetic, D. Mekterovic, S. Morovic, L. Tikvica, A. Attikis, G. Mavromanolakis, J. Mousa, C. Nicolaou, F. Ptochos, P. A. Razis, M. Finger, Y. Assran, A. Ellithi Kamel, M. A. Mahmoud, A. Mahrous, A. Radi, M. Kadastik, M. Müntel, M. Murumaa, M. Raidal, L. Rebane, A. Tiko, P. Eerola, G. Fedi, M. Voutilainen, J. Härkönen, V. Karimäki, R. Kinnunen, M. J. Kortelainen, T. Lampén, K. Lassila-Perini, S. Lehti, T. Lindén, P. Luukka, T. Mäenpää, T. Peltola, E. Tuominen, J. Tuominiemi, E. Tuovinen, L. Wendland, A. Korpela, T. Tuuva, M. Besancon, S. Choudhury, F. Couderc, M. Dejardin, D. Denegri, B. Fabbro, J. L. Faure, F. Ferri, S. Ganjour, A. Givernaud, P. Gras, G. Hamel de Monchenault, P. Jarry, E. Locci, J. Malcles, L. Millischer, A. Nayak, J. Rander, A. Rosowsky, M. Titov, S. Baffioni, F. Beaudette, L. Benhabib, L. Bianchini, M. Bluj, P. Busson, C. Charlot, N. Daci, T. Dahms, M. Dalchenko, L. Dobrzynski, A. Florent, R. Granier de Cassagnac, M. Haguenauer, P. Miné, C. Mironov, I. N. Naranjo, M. Nguyen, C. Ochando, P. Paganini, D. Sabes, R. Salerno, Y. Sirois, C. Veelken, A. Zabi, J.-L. Agram, J. Andrea, D. Bloch, D. Bodin, J.-M. Brom, E. C. Chabert, C. Collard, E. Conte, F. Drouhin, J.-C. Fontaine, D. Gelé, U. Goerlach, C. Goetzmann, P. Juillot, A.-C. Le Bihan, P. Van Hove, S. Gadrat, S. Beauceron, N. Beaupere, G. Boudoul, S. Brochet, J. Chasserat, R. Chierici, D. Contardo, P. Depasse, H. El Mamouni, J. Fay, S. Gascon, M. Gouzevitch, B. Ille, T. Kurca, M. Lethuillier, L. Mirabito, S. Perries, L. Sgandurra, V. Sordini, Y. Tschudi, M. Vander Donckt, P. Verdier, S. Viret, Z. Tsamalaidze, C. Autermann, S. Beranek, B. Calpas, M. Edelhoff, L. Feld, N. Heracleous, O. Hindrichs, K. Klein, A. Ostapchuk, A. Perieanu, F. Raupach, J. Sammet, S. Schael, D. Sprenger, H. Weber, B. Wittmer, V. Zhukov, M. Ata, J. Caudron, E. Dietz-Laursonn, D. Duchardt, M. Erdmann, R. Fischer, A. Güth, T. Hebbeker, C. Heidemann, K. Hoepfner, D. Klingebiel, P. Kreuzer, M. Merschmeyer, A. Meyer, M. Olschewski, K. Padeken, P. Papacz, H. Pieta, H. Reithler, S. A. Schmitz, L. Sonnenschein, J. Steggemann, D. Teyssier, S. Thüer, M. Weber, V. Cherepanov, Y. Erdogan, G. Flügge, H. Geenen, M. Geisler, W. Haj Ahmad, F. Hoehle, B. Kargoll, T. Kress, Y. Kuessel, J. Lingemann, A. Nowack, I. M. Nugent, L. Perchalla, O. Pooth, A. Stahl, M. Aldaya Martin, I. Asin, N. Bartosik, J. Behr, W. Behrenhoff, U. Behrens, M. Bergholz, A. Bethani, K. Borras, A. Burgmeier, A. Cakir, L. Calligaris, A. Campbell, F. Costanza, C. Diez Pardos, S. Dooling, T. Dorland, G. Eckerlin, D. Eckstein, G. Flucke, A. Geiser, I. Glushkov, P. Gunnellini, S. Habib, J. Hauk, G. Hellwig, H. Jung, M. Kasemann, P. Katsas, C. Kleinwort, H. Kluge, M. Krämer, D. Krücker, E. Kuznetsova, W. Lange, J. Leonard, K. Lipka, W. Lohmann, B. Lutz, R. Mankel, I. Marfin, I.-A. Melzer-Pellmann, A. B. Meyer, J. Mnich, A. Mussgiller, S. Naumann-Emme, O. Novgorodova, F. Nowak, J. Olzem, H. Perrey, A. Petrukhin, D. Pitzl, R. Placakyte, A. Raspereza, P. M. Ribeiro Cipriano, C. Riedl, E. Ron, M. Ö. Sahin, J. Salfeld-Nebgen, R. Schmidt, T. Schoerner-Sadenius, N. Sen, M. Stein, R. Walsh, C. Wissing, V. Blobel, H. Enderle, J. Erfle, U. Gebbert, M. Görner, M. Gosselink, J. Haller, K. Heine, R. S. Höing, G. Kaussen, H. Kirschenmann, R. Klanner, R. Kogler, J. Lange, I. Marchesini, T. Peiffer, N. Pietsch, D. Rathjens, C. Sander, H. Schettler, P. Schleper, E. Schlieckau, A. Schmidt, M. Schröder, T. Schum, M. Seidel, J. Sibille, V. Sola, H. Stadie, G. Steinbrück, J. Thomsen, D. Troendle, L. Vanelderen, C. Barth, C. Baus, J. Berger, C. Böser, T. Chwalek, W. De Boer, A. Descroix, A. Dierlamm, M. Feindt, M. Guthoff, C. Hackstein, F. Hartmann, T. Hauth, M. Heinrich, H. Held, K. H. Hoffmann, U. Husemann, I. Katkov, J. R. Komaragiri, A. Kornmayer, P. Lobelle Pardo, D. Martschei, S. Mueller, Th. Müller, M. Niegel, A. Nürnberg, O. Oberst, J. Ott, G. Quast, K. Rabbertz, F. Ratnikov, S. Röcker, F.-P. Schilling, G. Schott, H. J. Simonis, F. M. Stober, R. Ulrich, J. Wagner-Kuhr, S. Wayand, T. Weiler, M. Zeise, G. Anagnostou, G. Daskalakis, T. Geralis, S. Kesisoglou, A. Kyriakis, D. Loukas, A. Markou, C. Markou, E. Ntomari, L. Gouskos, T. J. Mertzimekis, A. Panagiotou, N. Saoulidou, E. Stiliaris, X. Aslanoglou, I. Evangelou, G. Flouris, C. Foudas, P. Kokkas, N. Manthos, I. Papadopoulos, E. Paradas, G. Bencze, C. Hajdu, P. Hidas, D. Horvath, B. Radics, F. Sikler, V. Veszpremi, G. Vesztergombi, A. J. Zsigmond, N. Beni, S. Czellar, J. Molnar, J. Palinkas, Z. Szillasi, J. Karancsi, P. Raics, Z. L. Trocsanyi, B. Ujvari, S. B. Beri, V. Bhatnagar, N. Dhingra, R. Gupta, M. Kaur, M. Z. Mehta, M. Mittal, N. Nishu, L. K. Saini, A. Sharma, J. B. Singh, Ashok Kumar, Arun Kumar, S. Ahuja, A. Bhardwaj, B. C. Choudhary, S. Malhotra, M. Naimuddin, K. Ranjan, P. Saxena, V. Sharma, R. K. Shivpuri, S. Banerjee, S. Bhattacharya, K. Chatterjee, S. Dutta, B. Gomber, Sa. Jain, Sh. Jain, R. Khurana, A. Modak, S. Mukherjee, D. Roy, S. Sarkar, M. Sharan, A. Abdulsalam, D. Dutta, S. Kailas, V. Kumar, A. K. Mohanty, L. M. Pant, P. Shukla, A. Topkar, T. Aziz, R. M. Chatterjee, S. Ganguly, S. Ghosh, M. Guchait, A. Gurtu, G. Kole, S. Kumar, M. Maity, G. Majumder, K. Mazumdar, G. B. Mohanty, B. Parida, K. Sudhakar, N. Wickramage, S. Dugad, H. Arfaei, H. Bakhshiansohi, S. M. Etesami, A. Fahim, H. Hesari, A. Jafari, M. Khakzad, M. Mohammadi Najafabadi, S. Paktinat Mehdiabadi, B. Safarzadeh, M. Zeinali, M. Grunewald, M. Abbrescia, L. Barbone, C. Calabria, S. S. Chhibra, A. Colaleo, D. Creanza, N. De Filippis, M. De Palma, L. Fiore, G. Iaselli, G. Maggi, M. Maggi, B. Marangelli, S. My, S. Nuzzo, N. Pacifico, A. Pompili, G. Pugliese, G. Selvaggi, L. Silvestris, G. Singh, R. Venditti, P. Verwilligen, G. Zito, G. Abbiendi, A. C. Benvenuti, D. Bonacorsi, S. Braibant-Giacomelli, L. Brigliadori, R. Campanini, P. Capiluppi, A. Castro, F. R. Cavallo, M. Cuffiani, G. M. Dallavalle, F. Fabbri, A. Fanfani, D. Fasanella, P. Giacomelli, C. Grandi, L. Guiducci, S. Marcellini, G. Masetti, M. Meneghelli, A. Montanari, F. L. Navarria, F. Odorici, A. Perrotta, F. Primavera, A. M. Rossi, T. Rovelli, G. P. Siroli, N. Tosi, R. Travaglini, S. Albergo, M. Chiorboli, S. 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Roland, G. Roland, G. S. F. Stephans, F. Stöckli, K. Sumorok, K. Sung, D. Velicanu, R. Wolf, B. Wyslouch, M. Yang, Y. Yilmaz, A. S. Yoon, M. Zanetti, V. Zhukova, B. Dahmes, A. De Benedetti, G. Franzoni, A. Gude, J. Haupt, S. C. Kao, K. Klapoetke, Y. Kubota, J. Mans, N. Pastika, R. Rusack, M. Sasseville, A. Singovsky, N. Tambe, J. Turkewitz, L. M. Cremaldi, R. Kroeger, L. Perera, R. Rahmat, D. A. Sanders, D. Summers, E. Avdeeva, K. Bloom, S. Bose, D. R. Claes, A. Dominguez, M. Eads, R. Gonzalez Suarez, J. Keller, I. Kravchenko, J. Lazo-Flores, S. Malik, F. Meier, G. R. Snow, J. Dolen, A. Godshalk, I. Iashvili, S. Jain, A. Kharchilava, A. Kumar, S. Rappoccio, Z. Wan, G. Alverson, E. Barberis, D. Baumgartel, M. Chasco, J. Haley, A. Massironi, D. Nash, T. Orimoto, D. Trocino, D. Wood, J. Zhang, A. Anastassov, K. A. Hahn, A. Kubik, L. Lusito, N. Mucia, N. Odell, B. Pollack, A. Pozdnyakov, M. Schmitt, S. Stoynev, M. Velasco, S. Won, D. Berry, A. Brinkerhoff, K. M. Chan, M. Hildreth, C. Jessop, D. J. Karmgard, J. Kolb, K. Lannon, W. Luo, S. Lynch, N. Marinelli, D. M. Morse, T. Pearson, M. Planer, R. Ruchti, J. Slaunwhite, N. Valls, M. Wayne, M. Wolf, L. Antonelli, B. Bylsma, L. S. Durkin, C. Hill, R. Hughes, K. Kotov, T. Y. Ling, D. Puigh, M. Rodenburg, G. Smith, C. Vuosalo, G. Williams, B. L. Winer, H. Wolfe, E. Berry, P. Elmer, V. Halyo, P. Hebda, J. Hegeman, A. Hunt, P. Jindal, S. A. Koay, D. Lopes Pegna, P. Lujan, D. Marlow, T. Medvedeva, M. Mooney, J. Olsen, P. Piroué, X. Quan, A. Raval, H. Saka, D. Stickland, C. Tully, J. S. Werner, S. C. Zenz, A. Zuranski, E. Brownson, A. Lopez, H. Mendez, J. E. Ramirez Vargas, E. Alagoz, D. Benedetti, G. Bolla, D. Bortoletto, M. De Mattia, A. Everett, Z. Hu, M. Jones, K. Jung, O. Koybasi, M. Kress, N. Leonardo, V. Maroussov, P. Merkel, D. H. Miller, N. Neumeister, I. Shipsey, D. Silvers, A. Svyatkovskiy, M. Vidal Marono, F. Wang, L. Xu, H. D. Yoo, J. Zablocki, Y. Zheng, S. Guragain, N. Parashar, A. Adair, B. Akgun, K. M. Ecklund, F. J. M. Geurts, B. P. Padley, R. Redjimi, J. Roberts, J. Zabel, B. Betchart, A. Bodek, R. Covarelli, P. de Barbaro, R. Demina, Y. Eshaq, T. Ferbel, A. Garcia-Bellido, P. Goldenzweig, J. Han, A. Harel, D. C. Miner, G. Petrillo, D. Vishnevskiy, M. Zielinski, A. Bhatti, R. Ciesielski, L. Demortier, K. Goulianos, G. Lungu, C. Mesropian, S. Arora, A. Barker, J. P. Chou, C. Contreras-Campana, E. Contreras-Campana, D. Duggan, D. Ferencek, Y. Gershtein, R. Gray, E. Halkiadakis, D. Hidas, A. Lath, S. Panwalkar, M. Park, R. Patel, V. Rekovic, J. Robles, K. Rose, S. Salur, S. Schnetzer, C. Seitz, S. Somalwar, R. Stone, S. Thomas, M. Walker, G. Cerizza, M. Hollingsworth, S. Spanier, Z. C. Yang, A. York, R. Eusebi, W. Flanagan, J. Gilmore, T. Kamon, V. Khotilovich, R. Montalvo, I. Osipenkov, Y. Pakhotin, A. Perloff, J. Roe, A. Safonov, T. Sakuma, I. Suarez, A. Tatarinov, D. Toback, N. Akchurin, J. Damgov, C. Dragoiu, P. R. Dudero, C. Jeong, K. Kovitanggoon, S. W. Lee, T. Libeiro, I. Volobouev, E. Appelt, A. G. Delannoy, S. Greene, A. Gurrola, W. Johns, C. Maguire, A. Melo, M. Sharma, P. Sheldon, B. Snook, S. Tuo, J. Velkovska, M. W. Arenton, S. Boutle, B. Cox, B. Francis, J. Goodell, R. Hirosky, A. Ledovskoy, C. Lin, C. Neu, J. Wood, S. Gollapinni, R. Harr, P. E. Karchin, C. Kottachchi Kankanamge Don, P. Lamichhane, A. Sakharov, M. Anderson, D. A. Belknap, L. Borrello, D. Carlsmith, M. Cepeda, S. Dasu, E. Friis, K. S. Grogg, M. Grothe, R. Hall-Wilton, M. Herndon, A. Hervé, K. Kaadze, P. Klabbers, J. Klukas, A. Lanaro, C. Lazaridis, R. Loveless, A. Mohapatra, M. U. Mozer, I. Ojalvo, G. A. Pierro, I. Ross, A. Savin, W. H. Smith, and J. Swanson
Subjects: Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Published: 2022
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29. Developing a parsimonious canopy model (PCM v1.0) to predict forest gross primary productivity and leaf area index of deciduous broad-leaved forest

Author: B. Bahrami, A. Hildebrandt, S. Thober, C. Rebmann, R. Fischer, L. Samaniego, O. Rakovec, and R. Kumar
Subjects: Geology, QE1-996.5
Abstract: Temperate forest ecosystems play a crucial role in governing global carbon and water cycles. However, unprecedented global warming presents fundamental alterations to the ecological functions (e.g., carbon uptake) and biophysical variables (e.g., leaf area index) of forests. The quantification of forest carbon uptake, gross primary productivity (GPP), as the largest carbon flux has a direct consequence on carbon budget estimations. Part of this assimilated carbon stored in leaf biomass is related to the leaf area index (LAI), which is closely linked to and is of critical significance in the water cycle. There already exist a number of models to simulate dynamics of LAI and GPP; however, the level of complexity, demanding data, and poorly known parameters often prohibit the model applicability over data-sparse and large domains. In addition, the complex mechanisms associated with coupling the terrestrial carbon and water cycles poses a major challenge for integrated assessments of interlinked processes (e.g., accounting for the temporal dynamics of LAI for improving water balance estimations and soil moisture availability for enhancing carbon balance estimations). In this study, we propose a parsimonious forest canopy model (PCM) to predict the daily dynamics of LAI and GPP with few required inputs, which would also be suitable for integration into state-of-the-art hydrologic models. The light use efficiency (LUE) concept, coupled with a phenology submodel, is central to PCM (v1.0). PCM estimates total assimilated carbon based on the efficiency of the conversion of absorbed photosynthetically active radiation into biomass. Equipped with the coupled phenology submodel, the total assimilated carbon partly converts to leaf biomass, from which prognostic and temperature-driven LAI is simulated. The model combines modules for the estimation of soil hydraulic parameters based on pedotransfer functions and vertically weighted soil moisture, considering the underground root distribution, when soil moisture data are available. We test the model on deciduous broad-leaved forest sites in Europe and North America, as selected from the FLUXNET network. We analyze the model's parameter sensitivity on the resulting GPP and LAI and identified, on average, 10 common sensitive parameters at each study site (e.g., LUE and SLA). The model's performance is evaluated in a validation period, using in situ measurements of GPP and LAI (when available) at eddy covariance flux towers. The model adequately captures the daily dynamics of observed GPP and LAI at each study site (Kling–Gupta efficiency, KGE, varies between 0.79 and 0.92). Finally, we investigate the cross-location transferability of model parameters and derive a compromise parameter set to be used across different sites. The model also showed robustness with the compromise single set of parameters, applicable to different sites, with an acceptable loss in model skill (on average ±8 %). Overall, in addition to the satisfactory performance of the PCM as a stand-alone canopy model, the parsimonious and modular structure of the developed PCM allows for a smooth incorporation of carbon modules to existing hydrologic models, thereby facilitating the seamless representation of coupled water and carbon cycle components, i.e., prognostic simulated vegetation leaf area index (LAI) would improve the representation of the water cycle components (i.e., evapotranspiration), while GPP predictions would benefit from the simulated soil water storage from a hydrologic model.
Published: 2022
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30. Characterization of fish assemblages in eleven multi-use reservoirs from North Carolina, USA

Author: Stephen W. Parker, Tyler Steven Coleman, Andrew K. Carlson, and Jesse R. Fischer
Subjects: Fish assemblage, reservoir, river, basin, environmental, gradient, Environmental sciences, GE1-350, Ecology, QH540-549.5
Abstract: AbstractManaging impounded river systems is a recurring challenge for aquatic resource professionals because reservoirs serve multiple functions with different ecological and socioeconomic outcomes. However, research on fishes in reservoirs has disproportionally focused on recreationally and economically important species, with less attention directed toward fish assemblages despite the potential for management at the assemblage level. As such, evaluation of relationships between reservoir fish assemblages and biotic and abiotic factors and testing whether assemblage structure is affected by changing environmental conditions may deepen ecological understanding and provide insights for reservoir fisheries management. Our overall objective was to assess these relationships in 11 reservoirs from North Carolina, USA. We sampled fish assemblages in the reservoirs, which spanned five river basins representing a range of habitat conditions, using experimental gillnets and pulsed DC nighttime electrofishing. Multivariate statistical analyses indicated that taxonomic differences in fish assemblage composition among river basins followed a gradient of productivity. The top contributing species to reservoir dissimilarity were bluegill (Lepomis macrochirus), gizzard shad (Dorosoma cepedianum), black crappie (Pomoxis nigromaculatus), and white perch (Morone americana). These four species were positively associated with factors that reflect increasing eutrophic conditions in the 11 reservoirs and could, therefore, serve as indicators of reservoir productivity, anthropogenic influence, and fish assemblage structure, in addition to their key role in reservoir fisheries management. Whereas fisheries research has historically focused on assessing fish populations, our results illustrate the ecological and management insights derived from simultaneously collecting assemblage- and population-level data. Research on reservoir fish assemblages in relation to biotic and abiotic conditions may help advance fish ecology and management alike.
Published: 2023
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31. Evaluation of structured doctoral training programs in German life sciences: how much do such programs address hurdles faced by doctoral candidates?

Author: Julia S. Meuleners, William J. Boone, Martin R. Fischer, Birgit J. Neuhaus, and Julia Eberle
Subjects: doctoral programs, interdisciplinary research, internationality, formal learning, supervision, examination, Education (General), L7-991
Abstract: IntroductionWays to improve the quality of doctoral education are debated internationally. In Europe, the United States, and other countries, there have been policy initiatives to address these. One approach has been the implementation of so-called structured doctoral training programs (doctoral programs) including formal structures such as courses, supervision agreements, external examiners for grading the thesis. However, there is little known about how doctoral programs implement the debated structures. As a result, the question arises whether existing programs already address the challenges of doctoral education and implement policy demands.MethodsIn this study, we evaluated the structure of 82 life science doctoral programs in Germany in a document analysis and a survey of program experts. We focused on (1) interdisciplinary aspects and (2) the international orientation of these programs. We evaluated the (3) courses offered, (4) formal characteristics of supervision, and (5) examination regulations of the doctoral programs.ResultsThe results showed that the doctoral programs already address these five aspects to some extent. However, there is variability as a function of institution and details of policy demand realizations are very heterogeneous. Some doctoral programs provide opportunities for interdisciplinary cooperation, but only few promote international orientation. Offered courses cover some relevant academic skills, but courses on, e.g., teaching, open access and public outreach are still rare. Structured regulations on supervision, e.g., through regular meetings and supervision agreements, are also rarely implemented. Lastly, most supervisors remain strongly involved in examining doctoral theses.DiscussionWe conclude that there is still a crucial need for improvement of doctoral programs through more extensive implementation of policy demands. We detail cross-national and -disciplinary practical implications for coordinators of doctoral programs.
Published: 2023
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32. Overconfidence effects and learning motivation refreshing BLS: An observational questionnaire study

Author: Stefan Bushuven, Joachim Bansbach, Michael Bentele, Milena Trifunovic-Koenig, Stefanie Bentele, Bianka Gerber, Fritz Hagen, Christian Friess, and Martin R. Fischer
Subjects: Basic Life Support, Cardiopulmonary Resuscitation, Lifelong Learning, Overconfidence, Clinical Tribalism, Specialties of internal medicine, RC581-951
Abstract: Aim of the study: Regular refresher skill courses are necessary to maintain competence in basic life support. The utilization of these training programs strongly depends on the motivation to learn. Learning motivation may be affected by overconfidence and clinical tribalism, as they both imply a higher competence compared to others, and therefore, a lower demand for training. This study aimed to assess how overconfidence in basic life support competencies affects learning motivation. Methods: We conducted a cross-sectional, observational, multicenter, anonymous online questionnaire survey using validated psychometric tests for healthcare professionals in Germany. Further, we tested participants’ knowledge and attitude regarding international basic life support guidelines. The study was conducted between March and April 2022, and healthcare providers from 22 German emergency medical services and hospitals at all levels were assessed. Results: Of 2,000 healthcare professionals assessed, 407 completed the assessment (response rate, 20.4%). We confirmed the presence of overconfidence and clinical tribalism (identity differentiation between social groups) among the 407 physicians, nurses, and emergency medical service providers who completed the survey. Three different learning-motivation groups emerged from cluster analysis: “experts” (confident and motivated), “recruitables” (overconfident and motivated), and “unawares” (overconfident and unmotivated). The three groups were present in all professional groups, independent of the frequency of exposure to cardiac arrest and educational level. Conclusions: These findings showed the presence of overconfidence effects and different learning motivation types in individuals learning basic life support, even in instructors.
Published: 2023
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33. Parametric dependencies of ion temperature profile peaking in ASDEX Upgrade high-beta scenarios

Author: M. Reisner, A. Di Siena, E. Fable, J. Stober, R. Fischer, R.M. McDermott, R. Bilato, A. Bock, T. Görler, and the ASDEX Upgrade Team
Subjects: internal transport barrier, E × B-shear, energetic particles, magnetic shear, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Advanced Tokamak (AT) scenarios are attractive candidates for future nuclear fusion power plants. These scenarios often feature peaked temperature profiles, suggesting a local reduction of turbulent transport. The mechanisms behind this are, as yet, not fully understood. Parameters that are thought to be connected to these transport reductions include the q -profile and the E × B -shear $\omega_{E\times B}$ . Another parameter considered to be important is the fast ion content, which can reduce transport in multiple different ways. This work presents AT experiments performed at the ASDEX Upgrade tokamak (AUG) in which these three parameters are varied to investigate their respective effect on the observed peaked ion temperature profiles. To disentangle potentially competing effects, simulations using the codes GENE and TGLF have been performed. It is found that the E × B -shear does not play a role in the AT scenarios performed at AUG, which have relatively low rotation, with $v_\mathrm{tor} = 100-250\,$ km h ^−1 . Experimentally, a significant dependence of $\smash{{\raise2.8pt\hbox{$\small\begin{array}{@{}l@{}}{{{R}}}\end{array}$}}}\!\!/\!\smash{{\raise-2.3pt\hbox{$\small\begin{array}{@{}l@{}}{L_{T_\mathrm{i}}}\end{array}$}}}$ on the electron cyclotron current drive settings was found, indicating that either the current profile (and, therefore, the q -profile) or $\smash{{\raise2.8pt\hbox{$\small\begin{array}{@{}l@{}}{{Te}}\end{array}$}}}\!\!/\!\smash{{\raise-2.3pt\hbox{$\small\begin{array}{@{}l@{}}{{Ti}}\end{array}$}}}$ has a significant impact on the observed suppression of turbulent transport. In support of the first option, both GENE and TGLF show a q -profile dependence of $\smash{{\raise2.8pt\hbox{$\small\begin{array}{@{}l@{}}{{{R}}}\end{array}$}}}\!\!/\!\smash{{\raise-2.3pt\hbox{$\small\begin{array}{@{}l@{}}{L_{T_\mathrm{i}}}\end{array}$}}}$ . Furthermore, according to GENE, electromagnetic (EM) fast ion effects are essential in reproducing the experimental results. Scans with TGLF (which does not include such effects), suggest that these fast ion effects become relevant above a threshold of $\smash{{\raise2.8pt\hbox{$\small\begin{array}{@{}l@{}}{{{R}}}\end{array}$}}}\!\!/\!\smash{{\raise-2.3pt\hbox{$\small\begin{array}{@{}l@{}}{L_{T_\mathrm{i}}}\end{array}$}}} = $ 4–5. In the presence of ICRF, additional electrostatic (ES) fast ion effects seem to come into effect, according to GENE, albeit to a smaller degree than the EM effects.
Published: 2024
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34. Effect of local wall clearance on scrape-off layer electron density profiles in ASDEX Upgrade

Author: B. Tal, E. Wolfrum, M. Bernert, G. Birkenmeier, D. Brida, R. Fischer, G. Grenfell, M. Griener, O. Grover, J. Hobirk, B. Kurzan, T. Lunt, P.A. Schneider, N. Vianello, D. Wendler, the ASDEX Upgrade Team, and the EUROfusion Tokamak Exploitation Team
Subjects: wall clearance, scrape-off layer, recycling, density profiles, plasma edge, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: The plasma electron density is measured with multiple diagnostics in the scrape-off layer of the ASDEX Upgrade tokamak. The recorded values are typically in good agreement in the case of exponentially decaying profiles at low densities, but they become inconsistent as soon as a density shoulder is formed, and up to a factor of 3 deviation is experienced at high densities. An idea is put forward; namely, that the local plasma-wall proximity has an influence on the local density and thus the measurement results depend on the local limiter-plasma and limiter-diagnostic distances at the same time. The effect of local wall clearance dependence is demonstrated by creating a plasma having an extremely high scrape-off layer density $\left(n_\mathrm{e} \gt 3\cdot10^{19}\,\textrm{m}^{-3}\right)$ after the H-L back transition and varying the position of the separatrix in different directions. As a possible physical process, neutral recycling at the plasma facing components is identified. Similar behaviour is also observed in the QCE regime, where the appearance of small ELMs barely impacts the scrape-off layer profiles. There are also indications that the local wall clearance does have an impact on the density profile not only in the scrape-off layer, but also in the confined region.
Published: 2024
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35. Characterization of highly radiating nitrogen-seeded H-mode plasmas in unfavorable BT at ASDEX Upgrade

Author: L. Chen, E. Wolfrum, O. Pan, B. Kurzan, M. Bernert, D. Brida, M. Cavedon, R. Dux, R. Fischer, M. Griener, O. Grover, U. Plank, D. Stieglitz, A. Zito, and the ASDEX Upgrade Team
Subjects: divertor detachment, radiative senario, impurity seeding, unfavorable, SOLPS-ITER, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: The highly radiating nitrogen-seeded H-mode plasmas in unfavorable B _T has been characterized in the ASDEX Upgrade tokamak (AUG). Three levels of nitrogen puffing rates have been injected into a fully detached H-mode plasma, which is run in lower single null configuration with the ion $B\times\nabla B$ drift away from the X-point. A cold ( ${\sim}1-2$ eV) highly radiating ( ${\sim}13.0 \mathrm{MW\,\,\,m}^{-3}$ ) region forms close to the X-point immediately after nitrogen seeding, as evidenced by measurements of the divertor Thomson scattering (DTS) and the two-dimensional bolometry reconstructions. In addition, the radiator moves further upwards above the X-point along the separatrix at the high-field side (HFS) with increasing nitrogen puffing rates, as evidenced by the Absolute eXtended UltraViolet (AXUV) measurements. The formation of the highly radiating regime is closely correlated to the modifications of the divertor plasma conditions. Along the line of sight of the DTS measurement, the electron temperature reduces down to a few eV, which initials near the X-point and further extends to the HFS scrape-off layer (SOL) simultaneously with the upward movement of the radiator, however, the electron temperature sustains ( ${\sim}30-50 $ eV) at the low-field side (LFS) SOL with slightly decreased electron density. The highly radiating regime shows LFS/HFS divertor asymmetry, in contrast to that for H-mode plasmas in favorable B _T , suggesting that the drifts play an important role for the formation of the highly radiating X-point regime at AUG. The neutral particle flux increases significantly (factor of ${\sim}2$ ) in the private flux region, while it increases slightly ( $ \lt\!20\%$ ) in the main chamber, thus suggesting an enhanced sub-divertor neutral compression with the formation of the highly radiating regime. Furthermore, a degradation of the pedestal electron density was observed with an enhancement of the electron temperature further inside the pedestal, and complete divertor detachment was achieved by nitrogen seeding with sustained plasma confinement. Finally, particle sources and flow patterns of deuterium and nitrogen ions have been analyzed by SOLPS-ITER modelling, confirming that the $E \,\times\,B$ drift plays an important role for the formation of the highly radiating regime in unfavorable B _T at AUG.
Published: 2024
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36. Progress towards edge-localized mode suppression via magnetic perturbations in hydrogen plasmas

Author: N. Leuthold, W. Suttrop, C. Paz-Soldan, M.G. Dunne, R. Fischer, E. Hinson, M. Knolker, F. Laggner, N.C. Logan, T. Osborne, D. Orlov, L. Schmitz, M. Shafer, M. Willensdorfer, the ASDEX Upgrade Team, and the EUROfusion MST1 Team
Subjects: resonant magnetic perturbations, edge-localized modes, suppression, hydrogen, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: The suppression of edge-localized modes (ELMs) by applying resonant magnetic perturbations (RMPs) is well studied in low collisionality deuterium plasmas as a measure to reduce transient divertor heat loads. However, ELM suppression has yet to be demonstrated in non-nuclear fuels such as hydrogen and hydrogen + helium mixtures which are the main ion species to be used in the ITER pre-fusion power operation (PFPO) phase. For the first time, attempts have been made to access ELM suppression with RMPs in ITER-like low collisionality hydrogen plasmas at DIII-D and ASDEX Upgrade. The DIII-D experiments focused on operation with injected power slightly above the L–H power threshold similar to the expected conditions in the ITER PFPO phase with limited external heating power. The RMPs were found to trigger H–L backtransitions, which is shown to be avoided by reducing the L–H power threshold by diluting the plasma with helium. The additional helium combined with a larger measured neutral density of hydrogen inside the separatrix compared to ELM suppressed deuterium plasmas precluded access to a pedestal top density below the known RMP-ELM suppression threshold. At ASDEX Upgrade, RMP-ELM suppression has been achieved when the concentration of ^1 H in the hydrogen isotope mix is below $40\%$ . While all known access criteria for RMP-ELM suppression were met above this threshold, full ELM suppression was replaced by strong mitigation. The most prominent difference between the hydrogen and deuterium plasmas was a change of turbulence characteristics in the pedestal where Doppler reflectometry measurements suggest a significant reduction of turbulence even at small hydrogen concentrations. In conclusion, these experiments not only identify issues that may prevent access to RMP-ELM suppression in the ITER PFPO phase, but also highlight missing physics in our current understanding of RMP-ELM suppression such as potentially the role of turbulence in the pedestal gradient region.
Published: 2024
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37. Overview of ASDEX upgrade results in view of ITER and DEMO

Author: H. Zohm, E. Alessi, C. Angioni, N. Arden, V. Artigues, M. Astrain, O. Asunta, M. Balden, V. Bandaru, A. Banon Navarro, M. Bauer, A. Bergmann, M. Bergmann, J. Bernardo, M. Bernert, A. Biancalani, R. Bielajew, R. Bilato, G. Birkenmeier, T. Blanken, V. Bobkov, A. Bock, L. Bock, T. Body, T. Bolzonella, N. Bonanomi, A. Bortolon, B. Böswirth, C. Bottereau, A. Bottino, H. van den Brand, M. Brenzke, S. Brezinsek, D. Brida, F. Brochard, J. Buchanan, A. Buhler, A. Burckhart, Y. Camenen, B. Cannas, P. Cano Megías, D. Carlton, M. Carr, P. Carvalho, C. Castaldo, A. Castillo Castillo, A. Cathey, M. Cavedon, C. Cazzaniga, C. Challis, A. Chankin, A. Chomiczewska, C. Cianfarani, F. Clairet, S. Coda, R. Coelho, J.W. Coenen, L. Colas, G. Conway, S. Costea, D. Coster, T. Cote, A.J. Creely, G. Croci, D.J. Cruz Zabala, G. Cseh, I. Cziegler, O. D’Arcangelo, A. Dal Molin, P. David, C. Day, M. de Baar, P. de Marné, R. Delogu, P. Denner, A. Di Siena, M. Dibon, J.J. Dominguez-Palacios Durán, D. Dunai, M. Dreval, M. Dunne, B.P. Duval, R. Dux, T. Eich, S. Elgeti, A. Encheva, B. Esposito, E. Fable, M. Faitsch, D. Fajardo Jimenez, U. Fantz, M. Farnik, H. Faugel, F. Felici, O. Ficker, A. Figueredo, R. Fischer, O. Ford, L. Frassinetti, M. Fröschle, G. Fuchert, J.C. Fuchs, H. Fünfgelder, S. Futatani, K. Galazka, J. Galdon-Quiroga, D. Gallart Escolà, A. Gallo, Y. Gao, S. Garavaglia, M. Garcia Muñoz, B. Geiger, L. Giannone, S. Gibson, L. Gil, E. Giovannozzi, I. Girka, O. Girka, T. Gleiter, S. Glöggler, M. Gobbin, J.C. Gonzalez, J. Gonzalez Martin, T. Goodman, G. Gorini, T. Görler, D. Gradic, G. Granucci, A. Gräter, G. Grenfell, H. Greuner, M. Griener, M. Groth, O. Grover, A. Gude, L. Guimarais, S. Günter, D. Hachmeister, A.H. Hakola, C. Ham, T. Happel, N. den Harder, G. Harrer, J. Harrison, V. Hauer, T. Hayward-Schneider, B. Heinemann, P. Heinrich, T. Hellsten, S. Henderson, P. Hennequin, M. Herschel, S. Heuraux, A. Herrmann, E. Heyn, F. Hitzler, J. Hobirk, K. Höfler, S. Hörmann, J.H. Holm, M. Hölzl, C. Hopf, L. Horvath, T. Höschen, A. Houben, A. Hubbard, A. Huber, K. Hunger, V. Igochine, M. Iliasova, J. Illerhaus, K. Insulander Björk, C. Ionita-Schrittwieser, I. Ivanova-Stanik, S. Jachmich, W. Jacob, N. Jaksic, A. Jansen van Vuuren, F. Jaulmes, F. Jenko, T. Jensen, E. Joffrin, A. Kallenbach, J. Kalis, A. Kappatou, J. Karhunen, C.-P. Käsemann, S. Kasilov, Y. Kazakov, A. Kendl, W. Kernbichler, E. Khilkevitch, M. Kircher, A. Kirk, S. Kjer Hansen, V. Klevarova, F. Klossek, G. Kocsis, M. Koleva, M. Komm, M. Kong, A. Krämer-Flecken, M. Krause, I. Krebs, A. Kreuzeder, K. Krieger, O. Kudlacek, D. Kulla, T. Kurki-Suonio, B. Kurzan, B. Labit, K. Lackner, F. Laggner, A. Lahtinen, P. Lainer, P.T. Lang, P. Lauber, M. Lehnen, L. Leppin, E. Lerche, N. Leuthold, L. Li, J. Likonen, O. Linder, H. Lindl, B. Lipschultz, Y. Liu, Z. Lu, T. Luda Di Cortemiglia, N.C. Luhmann, T. Lunt, A. Lyssoivan, T. Maceina, J. Madsen, A. Magnanimo, H. Maier, J. Mailloux, R. Maingi, O. Maj, E. Maljaars, V. Maquet, A. Mancini, A. Manhard, P. Mantica, M. Mantsinen, P. Manz, M. Maraschek, C. Marchetto, M. Markl, L. Marrelli, P. Martin, F. Matos, M. Mayer, P.J. McCarthy, R. McDermott, G. Meng, R. Merkel, A. Merle, H. Meyer, M. Michelini, D. Milanesio, V. Mitterauer, P. Molina Cabrera, M. Muraca, F. Nabais, V. Naulin, R. Nazikian, R.D. Nem, R. Neu, A.H. Nielsen, S.K. Nielsen, T. Nishizawa, M. Nocente, I. Novikau, S. Nowak, R. Ochoukov, J. Olsen, P. Oyola, O. Pan, G. Papp, A. Pau, G. Pautasso, C. Paz-Soldan, M. Peglau, E. Peluso, P. Petersson, C. Piron, U. Plank, B. Plaum, B. Plöckl, V. Plyusnin, G. Pokol, E. Poli, A. Popa, L. Porte, J. Puchmayr, T. Pütterich, L. Radovanovic, M. Ramisch, J. Rasmussen, G. Ratta, S. Ratynskaia, G. Raupp, A. Redl, D. Réfy, M. Reich, F. Reimold, D. Reiser, M. Reisner, D. Reiter, B. Rettino, T. Ribeiro, D. Ricci, R. Riedl, J. Riesch, J.F. Rivero Rodriguez, G. Rocchi, P. Rodriguez-Fernandez, V. Rohde, G. Ronchi, M. Rott, M. Rubel, D.A. Ryan, F. Ryter, S. Saarelma, M. Salewski, A. Salmi, O. Samoylov, L. Sanchis Sanchez, J. Santos, O. Sauter, G. Schall, A. Schlüter, J. Scholte, K. Schmid, O. Schmitz, P.A. Schneider, R. Schrittwieser, M. Schubert, C. Schuster, N. Schwarz, T. Schwarz-Selinger, J. Schweinzer, F. Sciortino, O. Seibold-Benjak, A. Shabbir, A. Shalpegin, S. Sharapov, U. Sheikh, A. Shevelev, G. Sias, M. Siccinio, B. Sieglin, A. Sigalov, A. Silva, C. Silva, D. Silvagni, J. Simpson, S. Sipilä, A. Snicker, E. Solano, C. Sommariva, C. Sozzi, M. Spacek, G. Spizzo, M. Spolaore, A. Stegmeir, M. Stejner, D. Stieglitz, J. Stober, U. Stroth, E. Strumberger, G. Suarez Lopez, W. Suttrop, T. Szepesi, B. Tál, T. Tala, W. Tang, G. Tardini, M. Tardocchi, D. Terranova, M. Teschke, E. Thorén, W. Tierens, D. Told, W. Treutterer, G. Trevisan, M. Tripský, P. Ulbl, G. Urbanczyk, M. Usoltseva, M. Valisa, M. Valovic, S. van Mulders, M. van Zeeland, F. Vannini, B. Vanovac, P. Varela, S. Varoutis, T. Verdier, G. Verdoolaege, N. Vianello, J. Vicente, T. Vierle, E. Viezzer, I. Voitsekhovitch, U. von Toussaint, D. Wagner, X. Wang, M. Weiland, D. Wendler, A.E. White, M. Willensdorfer, B. Wiringer, M. Wischmeier, R. Wolf, E. Wolfrum, Q. Yang, C. Yoo, Q. Yu, R. Zagórski, I. Zammuto, T. Zehetbauer, W. Zhang, W. Zholobenko, A. Zibrov, M. Zilker, C.F.B. Zimmermann, A. Zito, S. Zoletnik, the EUROfusion Tokamak Exploitation Team, and the ASDEX Upgrade Team
Subjects: tokamak, MHD stability, transport modelling, radiative exhaust, disruption physics, ELM free scenarios, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Experiments on ASDEX Upgrade (AUG) in 2021 and 2022 have addressed a number of critical issues for ITER and EU DEMO. A major objective of the AUG programme is to shed light on the underlying physics of confinement, stability, and plasma exhaust in order to allow reliable extrapolation of results obtained on present day machines to these reactor-grade devices. Concerning pedestal physics, the mitigation of edge localised modes (ELMs) using resonant magnetic perturbations (RMPs) was found to be consistent with a reduction of the linear peeling-ballooning stability threshold due to the helical deformation of the plasma. Conversely, ELM suppression by RMPs is ascribed to an increased pedestal transport that keeps the plasma away from this boundary. Candidates for this increased transport are locally enhanced turbulence and a locked magnetic island in the pedestal. The enhanced D-alpha (EDA) and quasi-continuous exhaust (QCE) regimes have been established as promising ELM-free scenarios. Here, the pressure gradient at the foot of the H-mode pedestal is reduced by a quasi-coherent mode, consistent with violation of the high-n ballooning mode stability limit there. This is suggestive that the EDA and QCE regimes have a common underlying physics origin. In the area of transport physics, full radius models for both L- and H-modes have been developed. These models predict energy confinement in AUG better than the commonly used global scaling laws, representing a large step towards the goal of predictive capability. A new momentum transport analysis framework has been developed that provides access to the intrinsic torque in the plasma core. In the field of exhaust, the X-Point Radiator (XPR), a cold and dense plasma region on closed flux surfaces close to the X-point, was described by an analytical model that provides an understanding of its formation as well as its stability, i.e., the conditions under which it transitions into a deleterious MARFE with the potential to result in a disruptive termination. With the XPR close to the divertor target, a new detached divertor concept, the compact radiative divertor, was developed. Here, the exhaust power is radiated before reaching the target, allowing close proximity of the X-point to the target. No limitations by the shallow field line angle due to the large flux expansion were observed, and sufficient compression of neutral density was demonstrated. With respect to the pumping of non-recycling impurities, the divertor enrichment was found to mainly depend on the ionisation energy of the impurity under consideration. In the area of MHD physics, analysis of the hot plasma core motion in sawtooth crashes showed good agreement with nonlinear 2-fluid simulations. This indicates that the fast reconnection observed in these events is adequately described including the pressure gradient and the electron inertia in the parallel Ohm’s law. Concerning disruption physics, a shattered pellet injection system was installed in collaboration with the ITER International Organisation. Thanks to the ability to vary the shard size distribution independently of the injection velocity, as well as its impurity admixture, it was possible to tailor the current quench rate, which is an important requirement for future large devices such as ITER. Progress was also made modelling the force reduction of VDEs induced by massive gas injection on AUG. The H-mode density limit was characterised in terms of safe operational space with a newly developed active feedback control method that allowed the stability boundary to be probed several times within a single discharge without inducing a disruptive termination. Regarding integrated operation scenarios, the role of density peaking in the confinement of the ITER baseline scenario (high plasma current) was clarified. The usual energy confinement scaling ITER98( p,y ) does not capture this effect, but the more recent H20 scaling does, highlighting again the importance of developing adequate physics based models. Advanced tokamak scenarios, aiming at large non-inductive current fraction due to non-standard profiles of the safety factor in combination with high normalised plasma pressure were studied with a focus on their access conditions. A method to guide the approach of the targeted safety factor profiles was developed, and the conditions for achieving good confinement were clarified. Based on this, two types of advanced scenarios (‘hybrid’ and ‘elevated’ q -profile) were established on AUG and characterised concerning their plasma performance.
Published: 2024
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38. Inter-discharge optimization for fast, reliable access to ASDEX Upgrade advanced tokamak scenario

Author: S. Van Mulders, O. Sauter, A. Bock, A. Burckhart, C. Contré, F. Felici, R. Fischer, R. Schramm, J. Stober, H. Zohm, and the ASDEX Upgrade Team
Subjects: ASDEX Upgrade, ramp-up optimization, neoclassical tearing modes, tokamak transport, advanced tokamak scenario, pre-discharge optimization, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Rapid inter-discharge simulation and optimization using the RAPTOR code have allowed the development of a reliable and reproducible early heating strategy for an advanced tokamak (AT) scenario on ASDEX Upgrade. Solving for electron heat and current diffusion in RAPTOR with ad-hoc formulas for heat transport and electron cyclotron current drive (ECCD) efficiency is found to robustly recover the coupled dynamics of $T_{\mathrm {e}}$ and q , while maintaining model parameters fixed for all discharges. The pedestal top boundary condition in pre-shot simulations is set by a newly derived scaling law for the electron pressure at ρ = 0.8, using a data set of previous AT discharges. RAPTOR simulations have allowed to develop an understanding of the onset of 3/2 tearing modes, which were observed to have a detrimental impact on confinement when low magnetic shear conditions are present at the rational surface during the high- β phase. Delaying the NBI heating, by a specific time interval found via simulations, has led to avoiding these modes. A non-linear optimization scheme has been applied to optimize the ECCD deposition radii to reach a stationary state with $q_{\mathrm {min}} \gt 1$ at the beginning of the flat-top phase, while ensuring a non-zero magnetic shear at q = 1.5 throughout the high- β phase, and has been successfully tested in experiment. However, further experiments, aiming for $q_{\mathrm {min}} \gt 1.5$ , have highlighted limitations of the present feedforward control approach in the presence of shot-to-shot variations that are not included in the applied model. Application of real-time model-based control is proposed to overcome model-reality mismatches in future work.
Published: 2024
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39. Overview of the EUROfusion Tokamak Exploitation programme in support of ITER and DEMO

Author: E. Joffrin, M. Wischmeier, M. Baruzzo, A. Hakola, A. Kappatou, D. Keeling, B. Labit, E. Tsitrone, N. Vianello, the ASDEX Upgrade Team, JET Contributors, the MAST-U Team, the TCV Team, the WEST Team, the EUROfusion Tokamak Exploitation Team:, D. Abate, J. Adamek, M. Agostini, C. Albert, F.C.P. Albert Devasagayam, S. Aleiferis, E. Alessi, J. Alhage, S. Allan, J. Allcock, M. Alonzo, G. Anastasiou, E. Andersson Sunden, C. Angioni, Y. Anquetin, L. Appel, G.M. Apruzzese, M. Ariola, C. Arnas, J.F. Artaud, W. Arter, O. Asztalos, L. Aucone, M.H. Aumeunier, F. Auriemma, J. Ayllon, E. Aymerich, A. Baciero, F. Bagnato, L. Bähner, F. Bairaktaris, P. Balázs, L. Balbinot, I. Balboa, M. Balden, A. Balestri, M. Baquero Ruiz, T. Barberis, C. Barcellona, O. Bardsley, S. Benkadda, T. Bensadon, E. Bernard, M. Bernert, H. Betar, R. Bianchetti Morales, J. Bielecki, R. Bilato, P. Bilkova, W. Bin, G. Birkenmeier, R. Bisson, P. Blanchard, A. Bleasdale, V. Bobkov, A. Boboc, A. Bock, K. Bogar, P. Bohm, T. Bolzonella, F. Bombarda, N. Bonanomi, L. Boncagni, D. Bonfiglio, R. Bonifetto, M. Bonotto, D. Borodin, I. Borodkina, T.O.S.J. Bosman, C. Bourdelle, C. Bowman, S. Brezinsek, D. Brida, F. Brochard, R. Brunet, D. Brunetti, V. Bruno, R. Buchholz, J. Buermans, H. Bufferand, P. Buratti, A. Burckhart, J. Cai, R. Calado, J. Caloud, S. Cancelli, F. Cani, B. Cannas, M. Cappelli, S. Carcangiu, A. Cardinali, S. Carli, D. Carnevale, M. Carole, M. Carpita, D. Carralero, F. Caruggi, I.S. Carvalho, I. Casiraghi, A. Casolari, F.J. Casson, C. Castaldo, A. Cathey, F. Causa, J. Cavalier, M. Cavedon, J. Cazabonne, M. Cecconello, L. Ceelen, A. Celora, J. Cerovsky, C.D. Challis, R. Chandra, A. Chankin, B. Chapman, H. Chen, M. Chernyshova, A.G. Chiariello, P. Chmielewski, A. Chomiczewska, C. Cianfarani, G. Ciraolo, J. Citrin, F. Clairet, S. Coda, R. Coelho, J.W. Coenen, I.H. Coffey, C. Colandrea, L. Colas, S. Conroy, C. Contre, N.J. Conway, L. Cordaro, Y. Corre, D. Costa, S. Costea, D. Coster, X. Courtois, C. Cowley, T. Craciunescu, G. Croci, A.M. Croitoru, K. Crombe, D.J. Cruz Zabala, G. Cseh, T. Czarski, A. Da Ros, A. Dal Molin, M. Dalla Rosa, Y. Damizia, O. D’Arcangelo, P. David, M. De Angeli, E. De la Cal, E. De La Luna, G. De Tommasi, J. Decker, R. Dejarnac, D. Del Sarto, G. Derks, C. Desgranges, P. Devynck, S. Di Genova, L.E. di Grazia, A. Di Siena, M. Dicorato, M. Diez, M. Dimitrova, T. Dittmar, L. Dittrich, J.J. Domínguez Palacios Durán, P. Donnel, D. Douai, S. Dowson, S. Doyle, M. Dreval, P. Drews, L. Dubus, R. Dumont, D. Dunai, M. Dunne, A. Durif, F. Durodie, G. Durr Legoupil Nicoud, B. Duval, R. Dux, T. Eich, A. Ekedahl, S. Elmore, G. Ericsson, J. Eriksson, B. Eriksson, F. Eriksson, S. Ertmer, A. Escarguel, B. Esposito, T. Estrada, E. Fable, M. Faitsch, N. Fakhrayi Mofrad, A. Fanni, T. Farley, M. Farník, N. Fedorczak, F. Felici, X. Feng, J. Ferreira, D. Ferreira, N. Ferron, O. Fevrier, O. Ficker, A.R. Field, A. Figueiredo, N. Fil, D. Fiorucci, M. Firdaouss, R. Fischer, M. Fitzgerald, M. Flebbe, M. Fontana, J. Fontdecaba Climent, A. Frank, E. Fransson, L. Frassinetti, D. Frigione, S. Futatani, R. Futtersack, S. Gabriellini, D. Gadariya, D. Galassi, K. Galazka, J. Galdon, S. Galeani, D. Gallart, A. Gallo, C. Galperti, M. Gambrioli, S. Garavaglia, J. Garcia, M. Garcia Munoz, J. Gardarein, L. Garzotti, J. Gaspar, R. Gatto, P. Gaudio, M. Gelfusa, J. Gerardin, S.N. Gerasimov, R. Gerru Miguelanez, G. Gervasini, Z. Ghani, F.M. Ghezzi, G. Ghillardi, L. Giannone, S. Gibson, L. Gil, A. Gillgren, E. Giovannozzi, C. Giroud, G. Giruzzi, T. Gleiter, M. Gobbin, V. Goloborodko, A. González Ganzábal, T. Goodman, V. Gopakumar, G. Gorini, T. Görler, S. Gorno, G. Granucci, D. Greenhouse, G. Grenfell, M. Griener, W. Gromelski, M. Groth, O. Grover, M. Gruca, A. Gude, C. Guillemaut, R. Guirlet, J. Gunn, T. Gyergyek, L. Hagg, J. Hall, C.J. Ham, M. Hamed, T. Happel, G. Harrer, J. Harrison, D. Harting, N.C. Hawkes, P. Heinrich, S. Henderson, P. Hennequin, R. Henriques, S. Heuraux, J. Hidalgo Salaverri, J. Hillairet, J.C. Hillesheim, A. Hjalmarsson, A. Ho, J. Hobirk, E. Hodille, M. Hölzl, M. Hoppe, J. Horacek, N. Horsten, L. Horvath, M. Houry, K. Hromasova, J. Huang, Z. Huang, A. Huber, E. Huett, P. Huynh, A. Iantchenko, M. Imrisek, P. Innocente, C. Ionita Schrittwieser, H. Isliker, P. Ivanova, I. Ivanova Stanik, M. Jablczynska, S. Jachmich, A.S. Jacobsen, P. Jacquet, A. Jansen van Vuuren, A. Jardin, H. Järleblad, A. Järvinen, F. Jaulmes, T. Jensen, I. Jepu, S. Jessica, T. Johnson, A. Juven, J. Kalis, J. Karhunen, R. Karimov, A.N. Karpushov, S. Kasilov, Y. Kazakov, P.V. Kazantzidis, W. Kernbichler, HT. Kim, D.B. King, V.G. Kiptily, A. Kirjasuo, K.K. Kirov, A. Kirschner, A. Kit, T. Kiviniemi, F. Kjær, E. Klinkby, A. Knieps, U. Knoche, M. Kochan, F. Köchl, G. Kocsis, J.T.W. Koenders, L. Kogan, Y. Kolesnichenko, Y. Kominis, M. Komm, M. Kong, B. Kool, S.B. Korsholm, D. Kos, M. Koubiti, J. Kovacic, Y. Kovtun, E. Kowalska Strzeciwilk, K. Koziol, M. Kozulia, A. Krämer Flecken, A. Kreter, K. Krieger, U. Kruezi, O. Krutkin, O. Kudlacek, U. Kumar, H. Kumpulainen, M.H. Kushoro, R. Kwiatkowski, M. La Matina, M. Lacquaniti, L. Laguardia, P. Lainer, P. Lang, M. Larsen, E. Laszynska, K.D. Lawson, A. Lazaros, E. Lazzaro, M.Y.K. Lee, S. Leerink, M. Lehnen, M. Lennholm, E. Lerche, Y. Liang, A. Lier, J. Likonen, O. Linder, B. Lipschultz, A. Listopad, X. Litaudon, E. Litherland Smith, D. Liuzza, T. Loarer, P.J. Lomas, J. Lombardo, N. Lonigro, R. Lorenzini, C. Lowry, T. Luda di Cortemiglia, A. Ludvig Osipov, T. Lunt, V. Lutsenko, E. Macusova, R. Mäenpää, P. Maget, C.F. Maggi, J. Mailloux, S. Makarov, K. Malinowski, P. Manas, A. Mancini, D. Mancini, P. Mantica, M. Mantsinen, J. Manyer, M. Maraschek, G. Marceca, G. Marcer, C. Marchetto, S. Marchioni, A. Mariani, M. Marin, M. Markl, T. Markovic, D. Marocco, S. Marsden, L. Martellucci, P. Martin, C. Martin, F. Martinelli, L. Martinelli, J.R. Martin Solis, R. Martone, M. Maslov, R. Masocco, M. Mattei, G.F. Matthews, D. Matveev, E. Matveeva, M.L. Mayoral, D. Mazon, S. Mazzi, C. Mazzotta, G. McArdle, R. McDermott, K. McKay, A.G. Meigs, C. Meineri, A. Mele, V. Menkovski, S. Menmuir, A. Merle, H. Meyer, K. Mikszuta Michalik, D. Milanesio, F. Militello, A. Milocco, I.G. Miron, J. Mitchell, R. Mitteau, V. Mitterauer, J. Mlynar, V. Moiseenko, P. Molna, F. Mombelli, C. Monti, A. Montisci, J. Morales, P. Moreau, J.M. Moret, A. Moro, D. Moulton, P. Mulholland, M. Muraglia, A. Murari, A. Muraro, P. Muscente, D. Mykytchuk, F. Nabais, Y. Nakeva, F. Napoli, E. Nardon, M.F. Nave, R.D. Nem, A. Nielsen, S.K. Nielsen, M. Nocente, R. Nouailletas, S. Nowak, H. Nyström, R. Ochoukov, N. Offeddu, S. Olasz, C. Olde, F. Oliva, D. Oliveira, H.J.C. Oliver, P. Ollus, J. Ongena, F.P. Orsitto, N. Osborne, R. Otin, P. Oyola Dominguez, D.I. Palade, S. Palomba, O. Pan, N. Panadero, E. Panontin, A. Papadopoulos, P. Papagiannis, G. Papp, V.V. Parail, C. Pardanaud, J. Parisi, A. Parrott, K. Paschalidis, M. Passoni, F. Pastore, A. Patel, B. Patel, A. Pau, G. Pautasso, R. Pavlichenko, E. Pawelec, B. Pegourie, G. Pelka, E. Peluso, A. Perek, E. Perelli Cippo, C. Perez Von Thun, P. Petersson, G. Petravich, Y. Peysson, V. Piergotti, L. Pigatto, C. Piron, L. Piron, A. Pironti, F. Pisano, U. Plank, B. Ploeckl, V. Plyusnin, A. Podolnik, Y. Poels, G. Pokol, J. Poley, G. Por, M. Poradzinski, F. Porcelli, L. Porte, C. Possieri, A. Poulsen, I. Predebon, G. Pucella, M. Pueschel, P. Puglia, O. Putignano, T. Pütterich, V. Quadri, A. Quercia, M. Rabinski, L. Radovanovic, R. Ragona, H. Raj, M. Rasinski, J. Rasmussen, G. Ratta, S. Ratynskaia, R. Rayaprolu, M. Rebai, A. Redl, D. Rees, D. Refy, M. Reich, H. Reimerdes, B.C.G. Reman, O. Renders, C. Reux, D. Ricci, M. Richou, S. Rienacker, D. Rigamonti, F. Rigollet, F.G. Rimini, D. Ripamonti, N. Rispoli, N. Rivals, J.F. Rivero Rodriguez, C. Roach, G. Rocchi, S. Rode, P. Rodrigues, J. Romazanov, C.F. Romero Madrid, J. Rosato, R. Rossi, G. Rubino, J. Rueda Rueda, J. Ruiz Ruiz, P. Ryan, D. Ryan, S. Saarelma, R. Sabot, M. Salewski, A. Salmi, L. Sanchis, A. Sand, J. Santos, K. Särkimäki, M. Sassano, O. Sauter, G. Schettini, S. Schmuck, P. Schneider, N. Schoonheere, R. Schramm, R. Schrittwieser, C. Schuster, N. Schwarz, F. Sciortino, M. Scotto D’Abusco, S. Scully, A. Selce, L. Senni, M. Senstius, G. Sergienko, S.E. Sharapov, R. Sharma, A. Shaw, U. Sheikh, G. Sias, B. Sieglin, S.A. Silburn, C. Silva, A. Silva, D. Silvagni, B. Simmendefeldt Schmidt, L. Simons, J. Simpson, L. Singh, S. Sipilä, Y. Siusko, S. Smith, A. Snicker, E.R. Solano, V. Solokha, M. Sos, C. Sozzi, F. Spineanu, G. Spizzo, M. Spolaore, L. Spolladore, C. Srinivasan, A. Stagni, Z. Stancar, G. Stankunas, J. Stober, P. Strand, C.I. Stuart, F. Subba, G.Y. Sun, H.J. Sun, W. Suttrop, J. Svoboda, T. Szepesi, G. Szepesi, B. Tal, T. Tala, P. Tamain, G. Tardini, M. Tardocchi, D. Taylor, G. Telesca, A. Tenaglia, A. Terra, D. Terranova, D. Testa, C. Theiler, E. Tholerus, B. Thomas, E. Thoren, A. Thornton, A. Thrysoe, Q. TICHIT, W. Tierens, A. Titarenko, P. Tolias, E. Tomasina, M. Tomes, E. Tonello, A. Tookey, M. Toscano Jiménez, C. Tsironis, C. Tsui, A. Tykhyy, M. Ugoletti, M. Usoltseva, D.F. Valcarcel, A. Valentini, M. Valisa, M. Vallar, M. Valovic, SI. Valvis, M. van Berkel, D. Van Eester, S. Van Mulders, M. van Rossem, R. Vann, B. Vanovac, J. Varela Rodriguez, J. Varje, S. Vartanian, M. Vecsei, L. Velarde Gallardo, M. Veranda, T. Verdier, G. Verdoolaege, K. Verhaegh, L. Vermare, G. Verona Rinati, J. Vicente, E. Viezzer, L. Vignitchouk, F. Villone, B. Vincent, P. Vincenzi, M.O. Vlad, G. Vogel, I. Voitsekhovitch, I. Voldiner, P. Vondracek, N.M.T. VU, T. Vuoriheimo, C. Wade, E. Wang, T. Wauters, M. Weiland, H. Weisen, N. Wendler, D. Weston, A. Widdowson, S. Wiesen, M. Wiesenberger, T. Wijkamp, M. Willensdorfer, T. Wilson, A. Wojenski, C. Wuethrich, I. Wyss, L. Xiang, S. Xu, D. Yadykin, Y. Yakovenko, H. Yang, V. Yanovskiy, R. Yi, B. Zaar, G. Zadvitskiy, L. Zakharov, P. Zanca, D. Zarzoso, Y. Zayachuk, J. Zebrowski, M. Zerbini, P. Zestanakis, C. F. B. Zimmermann, M. Zlobinski, A. Zohar, V.K. Zotta, X. Zou, M. Zuin, M. Zurita, and I. Zychor
Subjects: JET, ASDEX Upgrade, MAST-U, TCV, WEST, Tokamak Exploitation Task Force, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Within the 9th European Framework programme, since 2021 EUROfusion is operating five tokamaks under the auspices of a single Task Force called ‘Tokamak Exploitation’. The goal is to benefit from the complementary capabilities of each machine in a coordinated way and help in developing a scientific output scalable to future largre machines. The programme of this Task Force ensures that ASDEX Upgrade, MAST-U, TCV, WEST and JET (since 2022) work together to achieve the objectives of Missions 1 and 2 of the EUROfusion Roadmap: i) demonstrate plasma scenarios that increase the success margin of ITER and satisfy the requirements of DEMO and, ii) demonstrate an integrated approach that can handle the large power leaving ITER and DEMO plasmas. The Tokamak Exploitation task force has therefore organized experiments on these two missions with the goal to strengthen the physics and operational basis for the ITER baseline scenario and for exploiting the recent plasma exhaust enhancements in all four devices (PEX: Plasma EXhaust) for exploring the solution for handling heat and particle exhaust in ITER and develop the conceptual solutions for DEMO. The ITER Baseline scenario has been developed in a similar way in ASDEX Upgrade, TCV and JET. Key risks for ITER such as disruptions and run-aways have been also investigated in TCV, ASDEX Upgrade and JET. Experiments have explored successfully different divertor configurations (standard, super-X, snowflakes) in MAST-U and TCV and studied tungsten melting in WEST and ASDEX Upgrade. The input from the smaller devices to JET has also been proven successful to set-up novel control schemes on disruption avoidance and detachment.
Published: 2024
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40. Plasma profile reconstruction supported by kinetic modeling

Author: M. Bergmann, R. Fischer, C. Angioni, K. Höfler, P. Molina Cabrera, T. Görler, T. Luda, R. Bilato, G. Tardini, F. Jenko, and the ASDEX Upgrade team
Subjects: profile reconstruction, turbulence, kinetic modeling, transport, Bayesian statistics, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Combining the analysis of multiple diagnostics and well-chosen prior information in the framework of Bayesian probability theory, the Integrated Data Analysis code (IDA Fischer et al 2010 Fusion Sci. Technol. 58 675–84) can provide density and temperature radial profiles of fusion plasmas. These IDA-fitted measurements are then used for further analysis, such as discharge simulations and other experimental data analysis. Since IDA considers measurement data, which is frequently fragmentary, with statistical and systematic uncertainties, which are often difficult to quantify, from a heterogeneous set of diagnostics, the fitted profiles and their gradients may be in contradiction to well-established expectations from transport theory. Using the modeling suite ASTRA coupled with the quasi-linear transport solver TGLF, we have created a loop in which simulated profiles and their uncertainties are fed back into IDA as an additional prior, thus providing constraints about the physically reasonable parameter space. We apply this physics-motivated prior to several different plasma scenarios and find improved heat flux match, while still matching the experimental data. This work feeds into a broader effort to make IDA more robust against measurement uncertainties or lack of measurements by combining multiple transport solvers with different levels of complexity and computing costs in a multi-fidelity approach.
Published: 2024
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41. Experimental evidence for the drift wave nature of the weakly coherent mode in ASDEX Upgrade I-mode plasmas

Author: M. Herschel, T. Happel, D. Wendler, M. Griener, J. Kalis, R. Fischer, P. Manz, U. Stroth, and the ASDEX Upgrade Team
Subjects: weakly coherent mode, I-mode, ASDEX Upgrade, drift wave, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: The improved energy confinement mode (I-mode) is a potential candidate for future fusion power plants, as it combines ELM-free operation with good confinement. The unusual edge transport and turbulence in this regime is still not fully understood. This study analyzes the turbulent structure of the weakly coherent mode (WCM) in ASDEX Upgrade. Measurements from Doppler back-scattering and a thermal helium beam diagnostic are used to determine velocities of the background plasma and the WCM over multiple discharges. A phase velocity of the WCM of the order of 2–5 km s ^−1 in the electron diamagnetic drift direction is found, quantitatively close to a drift wave assuming negligible temperature fluctuations. A good agreement with a previously proposed mechanism behind the I-mode regime is observed. This marks the first experimental verification of a specific understanding of the WCM and the I-mode regime.
Published: 2024
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42. An extensive analysis of SOL properties in high-δ plasmas in ASDEX Upgrade

Author: A. Redl, T. Eich, N. Vianello, J. Adamek, M. Bernert, G. Birkenmeier, D. Brida, P. David, M. Faitsch, R. Fischer, G. Grenfell, R. Ochoukov, V. Rohde, B. Tal, M. Dreval, the ASDEX Upgrade Team, and the EUROfusion Tokamak Exploitation Team
Subjects: ASDEX Upgrade, power exhaust, QCE regime, filamentary transport, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: A set of dedicated H-mode discharges with constant heating power combining Neutral Beam Injection and Electron Cyclotron Resonance Heating have been executed at the ASDEX Upgrade tokamak using a high triangularity magnetic geometry in order to investigate the impact of filamentary transport to divertor and non-divertor components. The evolution of upstream scrape-off layer (SOL) profiles have been correlated with dedicated separatrix quantities, mostly with the turbulence control parameter $\alpha_{\mathrm{t}}$ (Eich and Manz 2021 Nucl. Fusion 61 086016) describing the turbulence level at the separatrix. With increasing $\alpha_{\mathrm{t}}$ , a broadening of the upstream density profiles in the near-SOL together with the formation of a density shoulder in the far-SOL have been observed. This phenomenon is associated with an enhanced filamentary transport dominating the radial turbulent transport in the far-SOL and confirmed by means of the cooling water calorimetry on non-divertor components. The probe measurements conducted with the ball-pen probe-head mounted on the midplane manipulator and a retarding-field analyzer close to the limiter surface indicate that the key mechanism increasing the radial filamentary transport to the first wall is an increase of the particle flux $\Gamma_\mathrm{r,fil}$ , caused primarily by the packing fraction $f_\mathrm{PF, fil}$ and the filament density $n_\mathrm{e,fil}$ . At the same time, the electron temperature $T_\mathrm{e}$ and ion temperature $T_\mathrm{i}$ measured close to the limiter surface show only small variations above $\alpha_\mathrm{t}$ > 0.5. Both the filamentary heat flux and the gross erosion derived from the first wall probe measurements reach a magnitude that should be considered in the design of future fusion reactors.
Published: 2024
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43. Development of a wireless, non-intrusive, MEMS-based pressure and acoustic measurement system for large-scale operating wind turbine blades

Author: S. Barber, J. Deparday, Y. Marykovskiy, E. Chatzi, I. Abdallah, G. Duthé, M. Magno, T. Polonelli, R. Fischer, and H. Müller
Subjects: Renewable energy sources, TJ807-830
Abstract: As the wind energy industry is maturing and wind turbines are becoming larger, there is an increasing need for cost-effective monitoring and data analysis solutions to understand the complex aerodynamic and acoustic behaviour of the flexible blades. Published measurements on operating rotor blades in real conditions are very scarce due to the complexity of the installation and use of measurement systems. However, recent developments in electronics, wireless communication and MEMS (micro-electromechanical systems) sensors are making it possible to acquire data in a cost-effective and energy-efficient way. In this work, therefore, a cost-effective MEMS-based aerodynamic and acoustic wireless measurement system that is thin, non-intrusive, easy to install, low power and self-sustaining is designed and tested in a wind tunnel. The measurement system does not require an electrical connection to the wind turbine and can be mounted and removed without damaging the blade.The results show that the system is capable of delivering relevant results continuously, although work needs to be done on calibrating and correcting the pressure signals as well as on refining the concept for the attachment sleeve for weather protection in the field. Finally, two methods for using the measurements to provide added value to the wind energy industry are developed and demonstrated: (1) inferring the local angle of attack via stagnation point detection using differential pressure sensors near the leading edge and (2) detecting and classifying leading edge erosion using instantaneous snapshots of the measured pressure fields. Ongoing work involves field tests on a 6 kW operating wind turbine in Switzerland.
Published: 2022
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44. Intranasal immunization with avian paramyxovirus type 3 expressing SARS-CoV-2 spike protein protects hamsters against SARS-CoV-2

Author: Hong-Su Park, Yumiko Matsuoka, Cindy Luongo, Lijuan Yang, Celia Santos, Xueqiao Liu, Laura R. H. Ahlers, Ian N. Moore, Sharmin Afroz, Reed F. Johnson, Bernard A. P. Lafont, David W. Dorward, Elizabeth R. Fischer, Craig Martens, Siba K. Samal, Shirin Munir, Ursula J. Buchholz, and Cyril Le Nouën
Subjects: Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract: Abstract Current vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are administered parenterally and appear to be more protective in the lower versus the upper respiratory tract. Vaccines are needed that directly stimulate immunity in the respiratory tract, as well as systemic immunity. We used avian paramyxovirus type 3 (APMV3) as an intranasal vaccine vector to express the SARS-CoV-2 spike (S) protein. A lack of pre-existing immunity in humans and attenuation by host-range restriction make APMV3 a vector of interest. The SARS-CoV-2 S protein was stabilized in its prefusion conformation by six proline substitutions (S-6P) rather than the two that are used in most vaccine candidates, providing increased stability. APMV3 expressing S-6P (APMV3/S-6P) replicated to high titers in embryonated chicken eggs and was genetically stable, whereas APMV3 expressing non-stabilized S or S-2P were unstable. In hamsters, a single intranasal dose of APMV3/S-6P induced strong serum IgG and IgA responses to the S protein and its receptor-binding domain, and strong serum neutralizing antibody responses to SARS-CoV-2 isolate WA1/2020 (lineage A). Sera from APMV3/S-6P-immunized hamsters also efficiently neutralized Alpha and Beta variants of concern. Immunized hamsters challenged with WA1/2020 did not exhibit the weight loss and lung inflammation observed in empty-vector-immunized controls; SARS-CoV-2 replication in the upper and lower respiratory tract of immunized animals was low or undetectable compared to the substantial replication in controls. Thus, a single intranasal dose of APMV3/S-6P was highly immunogenic and protective against SARS-CoV-2 challenge, suggesting that APMV3/S-6P is suitable for clinical development.
Published: 2022
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45. When silver doesn't shine anymore: The threat of increasing resistance to antibiotics and silver antiseptics

Author: Esther Kuenzli and Philip R. Fischer
Subjects: Infectious and parasitic diseases, RC109-216
Published: 2023
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46. Differences in perceptions of capability, autonomy, and expectations between residents and surgical team members in executing EPAs in Ethiopian medical education

Author: Equlinet Misganaw Amare, Matthias Siebeck, Tegbar Yigzaw, Martin R. Fischer, Mekdim Tadesse, and Markus Berndt
Subjects: Entrustable professional activities, Ethiopia, Graduating surgery residents, Surgical team, Surgical residency training, Science (General), Q1-390, Social sciences (General), H1-99
Abstract: Background: Entrustable Professional Activities (EPAs) are units of professional practice that are defined as tasks or responsibilities that are entrusted to an unsupervised execution by a trainee. In 2021, a framework of 29 EPAs was developed for surgical residency training programs in Ethiopia, with the goal of residents being able to perform independently by the time they graduate. However, studies show that surgical residents lack confidence and are unable to execute EPAs autonomously upon graduation, and concerns have been raised about graduate competencies in EPA execution. The goal of this research is to assess how surgical team members judge/perceive residents' performance in executing these EPAs autonomously at the time of graduation and how residents rate their own capability and autonomy in executing EPAs in order to systematically introduce and implement EPAs in Ethiopian medical education Methods: A survey was conducted in the Departments of Surgery at four residency training institutions in Ethiopia. All eligible surgical team members and final-year general surgery residents were invited to participate. Surgical team members were asked to rate the observed performance of a group of graduating surgical residents in each of the 29 EPAs, and residents were asked to rate their own capability in executing EPAs. The analysis focused on variations in performance ratings between surgical team members and residents, as well as across surgical team members. Results: A total of 125 surgical team members and 49 residents participated in this study. Residents rate their competence in performing these EPAs higher than surgical team members, mean 4.2 (SD = 0.63) vs. 3.7 (SD = 0.9). A statistically significant difference in perceptions of capability, autonomy, and expectations in executing EPAs was observed between the two groups of study (p = 0.03, CI: 0.51–0.95), as well as within surgical team members (p
Published: 2023
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47. Erratum to: Measurement of the top quark mass with lepton+jets final states using pp collisions at $$\sqrt{s} = 13\,\hbox {TeV}$$ s = 13 TeV

Author: A. M. Sirunyan, A. Tumasyan, W. Adam, F. Ambrogi, E. Asilar, T. Bergauer, J. Brandstetter, E. Brondolin, M. Dragicevic, J. Erö, A. Escalante Del Valle, M. Flechl, M. Friedl, R. Frühwirth, V. M. Ghete, J. Hrubec, M. Jeitler, N. Krammer, I. Krätschmer, D. Liko, T. Madlener, I. Mikulec, N. Rad, H. Rohringer, J. Schieck, R. Schöfbeck, M. Spanring, D. Spitzbart, A. Taurok, W. Waltenberger, J. Wittmann, C.-E. Wulz, M. Zarucki, V. Chekhovsky, V. Mossolov, J. Suarez Gonzalez, E. A. De Wolf, D. Di Croce, X. Janssen, J. Lauwers, M. Pieters, M. Van De Klundert, H. Van Haevermaet, P. Van Mechelen, N. Van Remortel, S. Abu Zeid, F. Blekman, J. D’Hondt, I. De Bruyn, J. De Clercq, K. Deroover, G. Flouris, D. Lontkovskyi, S. Lowette, I. Marchesini, S. Moortgat, L. Moreels, Q. Python, K. Skovpen, S. Tavernier, W. Van Doninck, P. Van Mulders, I. Van Parijs, D. Beghin, B. Bilin, H. Brun, B. Clerbaux, G. De Lentdecker, H. Delannoy, B. Dorney, G. Fasanella, L. Favart, R. Goldouzian, A. Grebenyuk, A. K. Kalsi, T. Lenzi, J. Luetic, T. Seva, E. Starling, C. Vander Velde, P. Vanlaer, D. Vannerom, R. Yonamine, T. Cornelis, D. Dobur, A. Fagot, M. Gul, I. Khvastunov, D. Poyraz, C. Roskas, D. Trocino, M. Tytgat, W. Verbeke, B. Vermassen, M. Vit, N. Zaganidis, H. Bakhshiansohi, O. Bondu, S. Brochet, G. Bruno, C. Caputo, A. Caudron, P. David, S. De Visscher, C. Delaere, M. Delcourt, B. Francois, A. Giammanco, G. Krintiras, V. Lemaitre, A. Magitteri, A. Mertens, M. Musich, K. Piotrzkowski, L. Quertenmont, A. Saggio, M. Vidal Marono, S. Wertz, J. Zobec, W. L. Aldá Júnior, F. L. Alves, G. A. Alves, L. Brito, G. Correia Silva, C. Hensel, A. Moraes, M. E. Pol, P. Rebello Teles, E. Belchior Batista Das Chagas, W. Carvalho, J. Chinellato, E. Coelho, E. M. Da Costa, G. G. Da Silveira, D. De Jesus Damiao, S. Fonseca De Souza, H. Malbouisson, M. Medina Jaime, M. Melo De Almeida, C. Mora Herrera, L. Mundim, H. Nogima, L. J. Sanchez Rosas, A. Santoro, A. Sznajder, M. Thiel, E. J. Tonelli Manganote, F. Torres Da Silva De Araujo, A. Vilela Pereira, S. Ahuja, C. A. Bernardes, Luigi Calligaris, T. R. Fernandez Perez Tomei, E. M. Gregores, P. G. Mercadante, S. F. Novaes, Sandra S. Padula, D. Romero Abad, J. C. Ruiz Vargas, A. Aleksandrov, R. Hadjiiska, P. Iaydjiev, A. Marinov, M. Misheva, M. Rodozov, M. Shopova, G. Sultanov, A. Dimitrov, L. Litov, B. Pavlov, P. Petkov, W. Fang, X. Gao, L. Yuan, M. Ahmad, J. G. Bian, G. M. Chen, H. S. Chen, M. Chen, Y. Chen, C. H. Jiang, D. Leggat, H. Liao, Z. Liu, F. Romeo, S. M. Shaheen, A. Spiezia, J. Tao, C. Wang, Z. Wang, E. Yazgan, H. Zhang, J. Zhao, Y. Ban, G. Chen, J. Li, Q. Li, S. Liu, Y. Mao, S. J. Qian, D. Wang, Z. Xu, Y. Wang, C. Avila, A. Cabrera, C. A. Carrillo Montoya, L. F. Chaparro Sierra, C. Florez, C. F. González Hernández, M. A. Segura Delgado, B. Courbon, N. Godinovic, D. Lelas, I. Puljak, T. Sculac, Z. Antunovic, M. Kovac, V. Brigljevic, D. Ferencek, K. Kadija, B. Mesic, A. Starodumov, T. Susa, M. W. Ather, A. Attikis, G. Mavromanolakis, J. Mousa, C. Nicolaou, F. Ptochos, P. A. Razis, H. Rykaczewski, M. Finger, E. Carrera Jarrin, M. A. Mahmoud, Elgammal A. Mohamed, E. Salama, S. Bhowmik, R. K. Dewanjee, M. Kadastik, L. Perrini, M. Raidal, C. Veelken, P. Eerola, H. Kirschenmann, J. Pekkanen, M. Voutilainen, J. Havukainen, J. K. Heikkilä, T. Järvinen, V. Karimäki, R. Kinnunen, T. Lampén, K. Lassila-Perini, S. Laurila, S. Lehti, T. Lindén, P. Luukka, T. Mäenpää, H. Siikonen, E. Tuominen, J. Tuominiemi, T. Tuuva, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, J. L. Faure, F. Ferri, S. Ganjour, S. Ghosh, A. Givernaud, P. Gras, G. Hamel de Monchenault, P. Jarry, C. Leloup, E. Locci, M. Machet, J. Malcles, G. Negro, J. Rander, A. Rosowsky, M.Ö. Sahin, M. Titov, A. Abdulsalam, C. Amendola, I. Antropov, S. Baffioni, F. Beaudette, P. Busson, L. Cadamuro, C. Charlot, R. Granier de Cassagnac, M. Jo, I. Kucher, S. Lisniak, A. Lobanov, J. Martin Blanco, M. Nguyen, C. Ochando, G. Ortona, P. Paganini, P. Pigard, R. Salerno, J. B. Sauvan, Y. Sirois, A. G. Stahl Leiton, Y. Yilmaz, A. Zabi, A. Zghiche, J.-L. Agram, J. Andrea, D. Bloch, J.-M. Brom, E. C. Chabert, C. Collard, E. Conte, X. Coubez, F. Drouhin, J.-C. Fontaine, D. Gelé, U. Goerlach, M. Jansová, P. Juillot, A.-C. Le Bihan, N. Tonon, P. Van Hove, S. Gadrat, S. Beauceron, C. Bernet, G. Boudoul, N. Chanon, R. Chierici, D. Contardo, P. Depasse, H. El Mamouni, J. Fay, L. Finco, S. Gascon, M. Gouzevitch, G. Grenier, B. Ille, F. Lagarde, I. B. Laktineh, H. Lattaud, M. Lethuillier, L. Mirabito, A. L. Pequegnot, S. Perries, A. Popov, V. Sordini, M. Vander Donckt, S. Viret, S. Zhang, T. Toriashvili, Z. Tsamalaidze, C. Autermann, L. Feld, M. K. Kiesel, K. Klein, M. Lipinski, M. Preuten, M. P. Rauch, C. Schomakers, J. Schulz, M. Teroerde, B. Wittmer, V. Zhukov, A. Albert, D. Duchardt, M. Endres, M. Erdmann, S. Erdweg, T. Esch, R. Fischer, A. Güth, T. Hebbeker, C. Heidemann, K. Hoepfner, S. Knutzen, M. Merschmeyer, A. Meyer, P. Millet, S. Mukherjee, T. Pook, M. Radziej, H. Reithler, M. Rieger, F. Scheuch, D. Teyssier, S. Thüer, G. Flügge, B. Kargoll, T. Kress, A. Künsken, T. Müller, A. Nehrkorn, A. Nowack, C. Pistone, O. Pooth, A. Stahl, M. Aldaya Martin, T. Arndt, C. Asawatangtrakuldee, I. Babounikau, K. Beernaert, O. Behnke, U. Behrens, A. Bermúdez Martínez, D. Bertsche, A. A. Bin Anuar, K. Borras, V. Botta, A. Campbell, P. Connor, C. Contreras-Campana, F. Costanza, V. Danilov, A. De Wit, C. Diez Pardos, D. Domínguez Damiani, G. Eckerlin, D. Eckstein, T. Eichhorn, A. Elwood, E. Eren, E. Gallo, J. Garay Garcia, A. Geiser, J. M. Grados Luyando, A. Grohsjean, P. Gunnellini, M. Guthoff, A. Harb, J. Hauk, H. Jung, M. Kasemann, J. Keaveney, C. Kleinwort, J. Knolle, I. Korol, D. Krücker, W. Lange, A. Lelek, T. Lenz, K. Lipka, W. Lohmann, R. Mankel, I.-A. Melzer-Pellmann, A. B. Meyer, M. Meyer, M. Missiroli, G. Mittag, J. Mnich, A. Mussgiller, S. K. Pflitsch, D. Pitzl, A. Raspereza, M. Savitskyi, P. Saxena, C. Schwanenberger, R. Shevchenko, A. Singh, N. Stefaniuk, H. Tholen, G. P. Van Onsem, R. Walsh, Y. Wen, K. Wichmann, C. Wissing, O. Zenaiev, R. Aggleton, S. Bein, V. Blobel, M. Centis Vignali, T. Dreyer, C. Garbers, E. Garutti, D. Gonzalez, J. Haller, A. Hinzmann, M. Hoffmann, A. Karavdina, G. Kasieczka, R. Klanner, R. Kogler, N. Kovalchuk, S. Kurz, V. Kutzner, J. Lange, D. Marconi, J. Multhaup, M. Niedziela, D. Nowatschin, T. Peiffer, A. Perieanu, A. Reimers, C. Scharf, P. Schleper, A. Schmidt, S. Schumann, J. Schwandt, J. Sonneveld, H. Stadie, G. Steinbrück, F. M. Stober, M. Stöver, D. Troendle, E. Usai, A. Vanhoefer, B. Vormwald, M. Akbiyik, C. Barth, M. Baselga, S. Baur, E. Butz, R. Caspart, T. Chwalek, F. Colombo, W. De Boer, A. Dierlamm, N. Faltermann, B. Freund, R. Friese, M. Giffels, M. A. Harrendorf, F. Hartmann, S. M. Heindl, U. Husemann, F. Kassel, S. Kudella, H. Mildner, M. U. Mozer, Th. Müller, M. Plagge, G. Quast, K. Rabbertz, M. Schröder, I. Shvetsov, G. Sieber, H. J. 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Gilmore, T. Huang, T. Kamon, R. Mueller, Y. Pakhotin, R. Patel, A. Perloff, L. Perniè, D. Rathjens, A. Safonov, A. Tatarinov, N. Akchurin, J. Damgov, F. De Guio, P. R. Dudero, J. Faulkner, E. Gurpinar, S. Kunori, K. Lamichhane, T. Mengke, S. Muthumuni, T. Peltola, S. Undleeb, I. Volobouev, S. Greene, A. Gurrola, R. Janjam, W. Johns, C. Maguire, A. Melo, H. Ni, K. Padeken, J. D. Ruiz Alvarez, P. Sheldon, S. Tuo, J. Velkovska, Q. Xu, M. W. Arenton, P. Barria, B. Cox, R. Hirosky, M. Joyce, A. Ledovskoy, H. Li, C. Neu, T. Sinthuprasith, E. Wolfe, F. Xia, R. Harr, P. E. Karchin, N. Poudyal, J. Sturdy, P. Thapa, S. Zaleski, M. Brodski, J. Buchanan, C. Caillol, D. Carlsmith, S. Dasu, L. Dodd, S. Duric, B. Gomber, M. Grothe, M. Herndon, A. Hervé, U. Hussain, P. Klabbers, A. Lanaro, A. Levine, K. Long, R. Loveless, V. Rekovic, T. Ruggles, A. Savin, N. Smith, W. H. Smith, N. Woods, and CMS Collaboration
Subjects: Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Published: 2022
Full Text: View/download PDF

48. Erratum to: Measurement of exclusive $$\Upsilon $$ Υ photoproduction from protons in pPb collisions at $${\sqrt{{s_{\mathrm{NN}}}}} = 5.02\,\hbox {TeV}$$ s NN = 5.02 TeV

Author: A. M. Sirunyan, A. Tumasyan, W. Adam, F. Ambrogi, E. Asilar, T. Bergauer, J. Brandstetter, E. Brondolin, M. Dragicevic, J. Erö, A. Escalante Del Valle, M. Flechl, M. Friedl, R. Frühwirth, V. M. Ghete, J. Grossmann, J. Hrubec, M. Jeitler, A. König, N. Krammer, I. Krätschmer, D. Liko, T. Madlener, I. Mikulec, E. Pree, N. Rad, H. Rohringer, J. Schieck, R. Schöfbeck, M. Spanring, D. Spitzbart, A. Taurok, W. Waltenberger, J. Wittmann, C.-E. Wulz, M. Zarucki, V. Chekhovsky, V. Mossolov, J. Suarez Gonzalez, E. A. De Wolf, D. Di Croce, X. Janssen, J. Lauwers, M. Pieters, M. Van De Klundert, H. Van Haevermaet, P. Van Mechelen, N. Van Remortel, S. Abu Zeid, F. Blekman, J. D’Hondt, I. De Bruyn, J. De Clercq, K. Deroover, G. Flouris, D. Lontkovskyi, S. Lowette, I. Marchesini, S. Moortgat, L. Moreels, Q. Python, K. Skovpen, S. Tavernier, W. Van Doninck, P. Van Mulders, I. Van Parijs, D. Beghin, B. Bilin, H. Brun, B. Clerbaux, G. De Lentdecker, H. Delannoy, B. Dorney, G. Fasanella, L. Favart, R. Goldouzian, A. Grebenyuk, A. K. Kalsi, T. Lenzi, J. Luetic, T. Seva, E. Starling, C. Vander Velde, P. Vanlaer, D. Vannerom, R. Yonamine, T. Cornelis, D. Dobur, A. Fagot, M. Gul, I. Khvastunov, D. Poyraz, C. Roskas, D. Trocino, M. Tytgat, W. Verbeke, B. Vermassen, M. Vit, N. Zaganidis, H. Bakhshiansohi, O. Bondu, S. Brochet, G. Bruno, C. Caputo, A. Caudron, P. David, S. De Visscher, C. Delaere, M. Delcourt, B. Francois, A. Giammanco, G. Krintiras, V. Lemaitre, A. Magitteri, A. Mertens, M. Musich, K. Piotrzkowski, L. Quertenmont, A. Saggio, M. Vidal Marono, S. Wertz, J. Zobec, W. L. Aldá Júnior, F. L. Alves, G.A. Alves, L. Brito, G. Correia Silva, C. Hensel, A. Moraes, M. E. Pol, P. Rebello Teles, E. Belchior Batista Das Chagas, W. Carvalho, J. Chinellato, E. Coelho, E. M. Da Costa, G.G. Da Silveira, D. De Jesus Damiao, S. Fonseca De Souza, H. Malbouisson, M. Medina Jaime, M. Melo De Almeida, C. Mora Herrera, L. Mundim, H. Nogima, L. J. Sanchez Rosas, A. Santoro, A. Sznajder, M. Thiel, E. J. Tonelli Manganote, F. Torres Da Silva De Araujo, A. Vilela Pereira, S. Ahuja, C. A. Bernardes, L. Calligaris, T. R. Fernandez Perez Tomei, E. M. Gregores, P. G. Mercadante, S. F. Novaes, Sandra S. Padula, D. Romero Abad, J. C. Ruiz Vargas, A. Aleksandrov, R. Hadjiiska, P. Iaydjiev, A. Marinov, M. Misheva, M. Rodozov, M. Shopova, G. Sultanov, A. Dimitrov, L. Litov, B. Pavlov, P. Petkov, W. Fang, X. Gao, L. Yuan, M. Ahmad, J. G. Bian, G. M. Chen, H. S. Chen, M. Chen, Y. Chen, C. H. Jiang, D. Leggat, H. Liao, Z. Liu, F. Romeo, S. M. Shaheen, A. Spiezia, J. Tao, C. Wang, Z. Wang, E. Yazgan, H. Zhang, J. Zhao, Y. Ban, G. Chen, J. Li, Q. Li, S. Liu, Y. Mao, S. J. Qian, D. Wang, Z. Xu, Y. Wang, C. Avila, A. Cabrera, C. A. Carrillo Montoya, L. F. Chaparro Sierra, C. Florez, C. F. González Hernández, M. A. Segura Delgado, B. Courbon, N. Godinovic, D. Lelas, I. Puljak, P. M. Ribeiro Cipriano, T. Sculac, Z. Antunovic, M. Kovac, V. Brigljevic, D. Ferencek, K. Kadija, B. Mesic, A. Starodumov, T. Susa, M. W. Ather, A. Attikis, G. Mavromanolakis, J. Mousa, C. Nicolaou, F. Ptochos, P. A. Razis, H. Rykaczewski, M. Finger, E. Carrera Jarrin, S. Khalil, M. A. Mahmoud, Y. Mohammed, S. Bhowmik, R. K. Dewanjee, M. Kadastik, L. Perrini, M. Raidal, C. Veelken, P. Eerola, H. Kirschenmann, J. Pekkanen, M. Voutilainen, J. Havukainen, J. K. Heikkilä, T. Järvinen, V. Karimäki, R. Kinnunen, T. Lampén, K. Lassila-Perini, S. Laurila, S. Lehti, T. Lindén, P. Luukka, T. Mäenpää, H. Siikonen, E. Tuominen, J. Tuominiemi, T. Tuuva, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, J. L. Faure, F. Ferri, S. Ganjour, S. Ghosh, A. Givernaud, P. Gras, G. Hamel de Monchenault, P. Jarry, C. Leloup, E. Locci, M. Machet, J. Malcles, G. Negro, J. Rander, A. Rosowsky, M. Ö. Sahin, M. Titov, A. Abdulsalam, C. Amendola, I. Antropov, S. Baffioni, F. Beaudette, P. Busson, L. Cadamuro, C. Charlot, R. Granier de Cassagnac, M. Jo, I. Kucher, S. Lisniak, A. Lobanov, J. Martin Blanco, M. 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Strobbe, L. Taylor, S. Tkaczyk, N. V. Tran, L. Uplegger, E. W. Vaandering, C. Vernieri, M. Verzocchi, R. Vidal, M. Wang, H. A. Weber, A. Whitbeck, W. Wu, D. Acosta, P. Avery, P. Bortignon, D. Bourilkov, A. Brinkerhoff, A. Carnes, M. Carver, D. Curry, R. D. Field, I. K. Furic, S. V. Gleyzer, B. M. Joshi, J. Konigsberg, A. Korytov, K. Kotov, P. Ma, K. Matchev, H. Mei, G. Mitselmakher, K. Shi, D. Sperka, N. Terentyev, L. Thomas, J. Wang, S. Wang, J. Yelton, Y. R. Joshi, S. Linn, P. Markowitz, J. L. Rodriguez, A. Ackert, T. Adams, A. Askew, S. Hagopian, V. Hagopian, K. F. Johnson, T. Kolberg, G. Martinez, T. Perry, H. Prosper, A. Saha, A. Santra, R. Yohay, M.M. Baarmand, V. Bhopatkar, S. Colafranceschi, M. Hohlmann, D. Noonan, T. Roy, F. Yumiceva, M. R. Adams, L. Apanasevich, D. Berry, R. R. Betts, R. Cavanaugh, X. Chen, S. Dittmer, O. Evdokimov, C.E. Gerber, D. A. Hangal, D. J. Hofman, K. Jung, J. Kamin, I. D. Sandoval Gonzalez, M. B. Tonjes, N. Varelas, H. Wang, Z. Wu, J. Zhang, B. Bilki, W. Clarida, K. Dilsiz, S. Durgut, R. P. Gandrajula, M. Haytmyradov, V. Khristenko, J.-P. Merlo, H. Mermerkaya, A. Mestvirishvili, A. Moeller, J. Nachtman, H. Ogul, Y. Onel, F. Ozok, A. Penzo, C. Snyder, E. Tiras, J. Wetzel, K. Yi, B. Blumenfeld, A. Cocoros, N. Eminizer, D. Fehling, L. Feng, A. V. Gritsan, W. T. Hung, P. Maksimovic, J. Roskes, U. Sarica, M. Swartz, M. Xiao, C. You, A. Al-bataineh, P. Baringer, A. Bean, S. Boren, J. Bowen, J. Castle, A. Kropivnitskaya, D. Majumder, W. Mcbrayer, M. Murray, C. Rogan, C. Royon, S. Sanders, E. Schmitz, J. D. Tapia Takaki, Q. Wang, A. Ivanov, K. Kaadze, Y. Maravin, A. Modak, A. Mohammadi, L. K. Saini, N. Skhirtladze, F. Rebassoo, D. Wright, A. Baden, O. Baron, A. Belloni, S.C. Eno, Y. Feng, C. Ferraioli, N. J. Hadley, S. Jabeen, G.Y. Jeng, R. G. Kellogg, J. Kunkle, A. C. Mignerey, F. Ricci-Tam, Y. H. Shin, A. Skuja, S. C. Tonwar, D. Abercrombie, B. Allen, V. Azzolini, R. Barbieri, A. Baty, G. Bauer, R. Bi, S. Brandt, W. Busza, I. A. Cali, M. D’Alfonso, Z. Demiragli, G. Gomez Ceballos, M. Goncharov, P. Harris, D. Hsu, M. Hu, Y. Iiyama, G. M. Innocenti, M. Klute, D. Kovalskyi, Y.-J. Lee, A. Levin, P. D. Luckey, B. Maier, A.C. Marini, C. Mcginn, C. Mironov, S. Narayanan, X. Niu, C. Paus, C. Roland, G. Roland, G. S. F. Stephans, K. Sumorok, K. Tatar, D. Velicanu, T. W. Wang, B. Wyslouch, S. Zhaozhong, A. C. Benvenuti, R. M. Chatterjee, A. Evans, P. Hansen, S. Kalafut, Y. Kubota, Z. Lesko, J. Mans, S. Nourbakhsh, N. Ruckstuhl, R. Rusack, J. Turkewitz, M. A. Wadud, J. G. Acosta, S. Oliveros, E. Avdeeva, K. Bloom, D. R. Claes, C. Fangmeier, F. Golf, R. Gonzalez Suarez, R. Kamalieddin, I. Kravchenko, J. Monroy, J. E. Siado, G. R. Snow, B. Stieger, A. Godshalk, C. Harrington, I. Iashvili, D. Nguyen, A. Parker, S. Rappoccio, B. Roozbahani, G. Alverson, E. Barberis, C. Freer, A. Hortiangtham, A. Massironi, D.M. Morse, T. Orimoto, R. Teixeira De Lima, T. Wamorkar, B. Wang, A. Wisecarver, D. Wood, O. Charaf, K. A. Hahn, N. Mucia, N. Odell, M.H. Schmitt, K. Sung, M. Trovato, M. Velasco, R. Bucci, N. Dev, M. Hildreth, K. Hurtado Anampa, C. Jessop, D. J. Karmgard, N. Kellams, K. Lannon, W. Li, N. Loukas, N. Marinelli, F. Meng, C. Mueller, Y. Musienko, M. Planer, A. Reinsvold, R. Ruchti, P. Siddireddy, G. Smith, S. Taroni, M. Wayne, A. Wightman, M. Wolf, A. Woodard, J. Alimena, L. Antonelli, B. Bylsma, L. S. Durkin, S. Flowers, B. Francis, A. Hart, C. Hill, W. Ji, T. Y. Ling, W. Luo, B. L. Winer, H. W. Wulsin, S. Cooperstein, O. Driga, P. Elmer, J. Hardenbrook, P. Hebda, S. Higginbotham, A. Kalogeropoulos, D. Lange, J. Luo, D. Marlow, K. Mei, I. Ojalvo, J. Olsen, C. Palmer, P. Piroué, J. Salfeld-Nebgen, D. Stickland, C. Tully, S. Norberg, A. Barker, V.E. Barnes, S. Das, L. Gutay, M. Jones, A.W. Jung, A. Khatiwada, D. H. Miller, N. Neumeister, C. C. Peng, H. Qiu, J. F. Schulte, J. Sun, F. Wang, R. Xiao, W. Xie, T. Cheng, J. Dolen, N. Parashar, Z. Chen, K. M. Ecklund, S. Freed, F.J.M. Geurts, M. Guilbaud, M. Kilpatrick, B. Michlin, B.P. Padley, J. Roberts, J. Rorie, W. Shi, Z. Tu, J. Zabel, A. Zhang, A. Bodek, P. de Barbaro, R. Demina, Y. t. Duh, T. Ferbel, M. Galanti, A. Garcia-Bellido, J. Han, O. Hindrichs, A. Khukhunaishvili, K. H. Lo, P. Tan, M. Verzetti, R. Ciesielski, K. Goulianos, C. Mesropian, A. Agapitos, J. P. Chou, Y. Gershtein, T.A. Gómez Espinosa, E. Halkiadakis, M. Heindl, E. Hughes, S. Kaplan, R. Kunnawalkam Elayavalli, S. Kyriacou, A. Lath, R. Montalvo, K. Nash, M. Osherson, H. Saka, S. Salur, S. Schnetzer, D. Sheffield, S. Somalwar, R. Stone, S. Thomas, P. Thomassen, M. Walker, A. G. Delannoy, J. Heideman, G. Riley, K. Rose, S. Spanier, K. Thapa, O. Bouhali, A. Castaneda Hernandez, A. Celik, M. Dalchenko, M. De Mattia, A. Delgado, S. Dildick, R. Eusebi, J. Gilmore, T. Huang, T. Kamon, R. Mueller, Y. Pakhotin, R. Patel, A. Perloff, L. Perniè, D. Rathjens, A. Safonov, A. Tatarinov, N. Akchurin, J. Damgov, F. De Guio, P. R. Dudero, J. Faulkner, E. Gurpinar, S. Kunori, K. Lamichhane, T. Mengke, S. Muthumuni, T. Peltola, S. Undleeb, I. Volobouev, S. Greene, A. Gurrola, R. Janjam, W. Johns, C. Maguire, A. Melo, H. Ni, K. Padeken, J.D. Ruiz Alvarez, P. Sheldon, S. Tuo, J. Velkovska, Q. Xu, M. W. Arenton, P. Barria, B. Cox, R. Hirosky, M. Joyce, A. Ledovskoy, H. Li, C. Neu, T. Sinthuprasith, E. Wolfe, F. Xia, R. Harr, P. E. Karchin, N. Poudyal, J. Sturdy, P. Thapa, S. Zaleski, M. Brodski, J. Buchanan, C. Caillol, D. Carlsmith, S. Dasu, L. Dodd, S. Duric, B. Gomber, M. Grothe, M. Herndon, A. Hervé, U. Hussain, P. Klabbers, A. Lanaro, A. Levine, K. Long, R. Loveless, V. Rekovic, T. Ruggles, A. Savin, N. Smith, W. H. Smith, N. Woods, and CMS Collaboration
Subjects: Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Published: 2022
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49. Modelling submerged biofouled microplastics and their vertical trajectories

Author: R. Fischer, D. Lobelle, M. Kooi, A. Koelmans, V. Onink, C. Laufkötter, L. Amaral-Zettler, A. Yool, and E. van Sebille
Subjects: Ecology, QH540-549.5, Life, QH501-531, Geology, QE1-996.5
Abstract: The fate of (micro)plastic particles in the open ocean is controlled by biological and physical processes. Here, we model the effects of biofouling on the subsurface vertical distribution of spherical, virtual plastic particles with radii of 0.01–1 mm. The biological specifications include the attachment, growth and loss of algae on particles. The physical specifications include four vertical velocity terms: advection, wind-driven mixing, tidally induced mixing and the sinking velocity of the biofouled particle. We track 10 000 particles for 1 year in three different regions with distinct biological and physical properties: the low-productivity region of the North Pacific Subtropical Gyre, the high-productivity region of the equatorial Pacific and the high mixing region of the Southern Ocean. The growth of biofilm mass in the euphotic zone and loss of mass below the euphotic zone result in the oscillatory behaviour of particles, where the larger (0.1–1.0 mm) particles have much shorter average oscillation lengths ( d; 90th percentile) than the smaller (0.01–0.1 mm) particles (up to 130 d; 90th percentile). A subsurface maximum particle concentration occurs just below the mixed-layer depth (around 30 m) in the equatorial Pacific, which is most pronounced for larger particles (0.1–1.0 mm). This occurs because particles become neutrally buoyant when the processes affecting the settling velocity of a particle and the seawater's vertical movement are in equilibrium. Seasonal effects in the subtropical gyre result in particles sinking below the mixed-layer depth only during spring blooms but otherwise remaining within the mixed layer. The strong winds and deepest average mixed-layer depth in the Southern Ocean (400 m) result in the deepest redistribution of particles (>5000 m). Our results show that the vertical movement of particles is mainly affected by physical (wind-induced mixing) processes within the mixed-layer and biological (biofilm) dynamics below the mixed layer. Furthermore, positively buoyant particles with radii of 0.01–1.0 mm can sink far below the euphotic zone and mixed layer in regions with high near-surface mixing or high biological activity. This work can easily be coupled to other models to simulate open-ocean biofouling dynamics, in order to reach a better understanding of where ocean (micro)plastic ends up.
Published: 2022
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50. Erratum to: Search for new physics in dijet angular distributions using proton-proton collisions at $$\sqrt{s} = 13\,\hbox {TeV}$$ s = 13 TeV and constraints on dark matter and other models

Author: A. M. Sirunyan, A. Tumasyan, W. Adam, F. Ambrogi, E. Asilar, T. Bergauer, J. Brandstetter, E. Brondolin, M. Dragicevic, J. Erö, A. Escalante Del Valle, M. Flechl, M. Friedl, R. Frühwirth, V. M. Ghete, J. Grossmann, J. Hrubec, M. Jeitler, A. König, N. Krammer, I. Krätschmer, D. Liko, T. Madlener, I. Mikulec, E. Pree, N. Rad, H. Rohringer, J. Schieck, R. Schöfbeck, M. Spanring, D. Spitzbart, A. Taurok, W. Waltenberger, J. Wittmann, C.-E. Wulz, M. Zarucki, V. Chekhovsky, V. Mossolov, J. Suarez Gonzalez, E. A. De Wolf, D. Di Croce, X. Janssen, J. Lauwers, M. Pieters, M. Van De Klundert, H. Van Haevermaet, P. Van Mechelen, N. Van Remortel, S. Abu Zeid, F. Blekman, J. D’Hondt, I. De Bruyn, J. De Clercq, K. Deroover, G. Flouris, D. Lontkovskyi, S. Lowette, I. Marchesini, S. Moortgat, L. Moreels, Q. Python, K. Skovpen, S. Tavernier, W. Van Doninck, P. Van Mulders, I. Van Parijs, D. Beghin, B. Bilin, H. Brun, B. Clerbaux, G. De Lentdecker, H. Delannoy, B. Dorney, G. Fasanella, L. Favart, R. Goldouzian, A. Grebenyuk, A. K. Kalsi, T. Lenzi, J. Luetic, T. Seva, E. Starling, C. Vander Velde, P. Vanlaer, D. Vannerom, R. Yonamine, T. Cornelis, D. Dobur, A. Fagot, M. Gul, I. Khvastunov, D. Poyraz, C. Roskas, D. Trocino, M. Tytgat, W. Verbeke, B. Vermassen, M. Vit, N. Zaganidis, H. Bakhshiansohi, O. Bondu, S. Brochet, G. Bruno, C. Caputo, A. Caudron, P. David, S. De Visscher, C. Delaere, M. Delcourt, B. Francois, A. Giammanco, G. Krintiras, V. Lemaitre, A. Magitteri, A. Mertens, M. Musich, K. Piotrzkowski, L. Quertenmont, A. Saggio, M. Vidal Marono, S. Wertz, J. Zobec, W. L. Aldá Júnior, F. L. Alves, G. A. Alves, L. Brito, G. Correia Silva, C. Hensel, A. Moraes, M. E. Pol, P. Rebello Teles, E. Belchior Batista Das Chagas, W. Carvalho, J. Chinellato, E. Coelho, E. M. Da Costa, G. G. Da Silveira, D. De Jesus Damiao, S. Fonseca De Souza, H. Malbouisson, M. Medina Jaime, M. Melo De Almeida, C. Mora Herrera, L. Mundim, H. Nogima, L. J. Sanchez Rosas, A. Santoro, A. Sznajder, M. Thiel, E. J. Tonelli Manganote, F. Torres Da Silva De Araujo, A. Vilela Pereira, S. Ahuja, C. A. Bernardes, L. Calligaris, T. R. Fernandez Perez Tomei, E. M. Gregores, P. G. Mercadante, S. F. Novaes, Sandra S. Padula, D. Romero Abad, J. C. Ruiz Vargas, A. Aleksandrov, R. Hadjiiska, P. Iaydjiev, A. Marinov, M. Misheva, M. Rodozov, M. Shopova, G. Sultanov, A. Dimitrov, L. Litov, B. Pavlov, P. Petkov, W. Fang, X. Gao, L. Yuan, M. Ahmad, J. G. Bian, G. M. Chen, H. S. Chen, M. Chen, Y. Chen, C. H. Jiang, D. Leggat, H. Liao, Z. Liu, F. Romeo, S. M. Shaheen, A. Spiezia, J. Tao, C. Wang, Z. Wang, E. Yazgan, H. Zhang, J. Zhao, Y. Ban, G. Chen, J. Li, Q. Li, S. Liu, Y. Mao, S. J. Qian, D. Wang, Z. Xu, Y. Wang, C. Avila, A. Cabrera, C. A. Carrillo Montoya, L. F. Chaparro Sierra, C. Florez, C. F. González Hernández, M. A. Segura Delgado, B. Courbon, N. Godinovic, D. Lelas, I. Puljak, P. M. Ribeiro Cipriano, T. Sculac, Z. Antunovic, M. Kovac, V. Brigljevic, D. Ferencek, K. Kadija, B. Mesic, A. Starodumov, T. Susa, M. W. Ather, A. Attikis, G. Mavromanolakis, J. Mousa, C. Nicolaou, F. Ptochos, P. A. Razis, H. Rykaczewski, M. Finger, E. Carrera Jarrin, Y. Assran, S. Elgammal, S. Khalil, S. Bhowmik, R. K. Dewanjee, M. Kadastik, L. Perrini, M. Raidal, C. Veelken, P. Eerola, H. Kirschenmann, J. Pekkanen, M. Voutilainen, J. Havukainen, J. K. Heikkilä, T. Järvinen, V. Karimäki, R. Kinnunen, T. Lampén, K. Lassila-Perini, S. Laurila, S. Lehti, T. Lindén, P. Luukka, T. Mäenpää, H. Siikonen, E. Tuominen, J. Tuominiemi, T. Tuuva, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, J. L. Faure, F. Ferri, S. Ganjour, S. Ghosh, A. Givernaud, P. Gras, G. Hamel de Monchenault, P. Jarry, C. Leloup, E. Locci, M. Machet, J. Malcles, G. Negro, J. Rander, A. Rosowsky, M.Ö. Sahin, M. Titov, A. Abdulsalam, C. Amendola, I. Antropov, S. Baffioni, F. Beaudette, P. Busson, L. Cadamuro, C. Charlot, R. Granier de Cassagnac, M. Jo, I. Kucher, S. Lisniak, A. Lobanov, J. Martin Blanco, M. Nguyen, C. Ochando, G. Ortona, P. Paganini, P. Pigard, R. Salerno, J. B. Sauvan, Y. Sirois, A. G. Stahl Leiton, Y. Yilmaz, A. Zabi, A. Zghiche, J.-L. Agram, J. Andrea, D. Bloch, J.-M. Brom, E. C. Chabert, C. Collard, E. Conte, X. Coubez, F. Drouhin, J.-C. Fontaine, D. Gelé, U. Goerlach, M. Jansová, P. Juillot, A.-C. Le Bihan, N. Tonon, P. Van Hove, S. Gadrat, S. Beauceron, C. Bernet, G. Boudoul, N. Chanon, R. Chierici, D. Contardo, P. Depasse, H. El Mamouni, J. Fay, L. Finco, S. Gascon, M. Gouzevitch, G. Grenier, B. Ille, F. Lagarde, I. B. Laktineh, H. Lattaud, M. Lethuillier, L. Mirabito, A. L. Pequegnot, S. Perries, A. Popov, V. Sordini, M. Vander Donckt, S. Viret, S. Zhang, T. Toriashvili, Z. Tsamalaidze, C. Autermann, L. Feld, M. K. Kiesel, K. Klein, M. Lipinski, M. Preuten, M. P. Rauch, C. Schomakers, J. Schulz, M. Teroerde, B. Wittmer, V. Zhukov, A. Albert, D. Duchardt, M. Endres, M. Erdmann, S. Erdweg, T. Esch, R. Fischer, A. Güth, T. Hebbeker, C. Heidemann, K. Hoepfner, S. Knutzen, M. Merschmeyer, A. Meyer, P. Millet, S. Mukherjee, T. Pook, M. Radziej, H. Reithler, M. Rieger, F. Scheuch, D. Teyssier, S. Thüer, G. Flügge, B. Kargoll, T. Kress, A. Künsken, T. Müller, A. Nehrkorn, A. Nowack, C. Pistone, O. Pooth, A. Stahl, M. Aldaya Martin, T. Arndt, C. Asawatangtrakuldee, K. Beernaert, O. Behnke, U. Behrens, A. Bermúdez Martínez, A. A. Bin Anuar, K. Borras, V. Botta, A. Campbell, P. Connor, C. Contreras-Campana, F. Costanza, V. Danilov, A. De Wit, C. Diez Pardos, D. Domínguez Damiani, G. Eckerlin, D. Eckstein, T. Eichhorn, A. Elwood, E. Eren, E. Gallo, J. Garay Garcia, A. Geiser, J. M. Grados Luyando, A. Grohsjean, P. Gunnellini, M. Guthoff, A. Harb, J. Hauk, M. Hempel, H. Jung, M. Kasemann, J. Keaveney, C. Kleinwort, J. Knolle, I. Korol, D. Krücker, W. Lange, A. Lelek, T. Lenz, K. Lipka, W. Lohmann, R. Mankel, I.-A. Melzer-Pellmann, A. B. Meyer, M. Meyer, M. Missiroli, G. Mittag, J. Mnich, A. Mussgiller, D. Pitzl, A. Raspereza, M. Savitskyi, P. Saxena, R. 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Schneider, E. Sexton-Kennedy, A. Soha, W. J. Spalding, L. Spiegel, S. Stoynev, J. Strait, N. Strobbe, L. Taylor, S. Tkaczyk, N. V. Tran, L. Uplegger, E. W. Vaandering, C. Vernieri, M. Verzocchi, R. Vidal, M. Wang, H. A. Weber, A. Whitbeck, W. Wu, D. Acosta, P. Avery, P. Bortignon, D. Bourilkov, A. Brinkerhoff, A. Carnes, M. Carver, D. Curry, R. D. Field, I. K. Furic, S. V. Gleyzer, B. M. Joshi, J. Konigsberg, A. Korytov, K. Kotov, P. Ma, K. Matchev, H. Mei, G. Mitselmakher, K. Shi, D. Sperka, N. Terentyev, L. Thomas, J. Wang, S. Wang, J. Yelton, Y. R. Joshi, S. Linn, P. Markowitz, J. L. Rodriguez, A. Ackert, T. Adams, A. Askew, S. Hagopian, V. Hagopian, K. F. Johnson, T. Kolberg, G. Martinez, T. Perry, H. Prosper, A. Saha, A. Santra, R. Yohay, M. M. Baarmand, V. Bhopatkar, S. Colafranceschi, M. Hohlmann, D. Noonan, T. Roy, F. Yumiceva, M. R. Adams, L. Apanasevich, D. Berry, R. R. Betts, R. Cavanaugh, X. Chen, S. Dittmer, O. Evdokimov, C. E. Gerber, D. A. Hangal, D. J. Hofman, K. Jung, J. Kamin, I. D. Sandoval Gonzalez, M. B. Tonjes, N. Varelas, H. Wang, Z. Wu, J. Zhang, B. Bilki, W. Clarida, K. Dilsiz, S. Durgut, R. P. Gandrajula, M. Haytmyradov, V. Khristenko, J.-P. Merlo, H. Mermerkaya, A. Mestvirishvili, A. Moeller, J. Nachtman, H. Ogul, Y. Onel, F. Ozok, A. Penzo, C. Snyder, E. Tiras, J. Wetzel, K. Yi, B. Blumenfeld, A. Cocoros, N. Eminizer, D. Fehling, L. Feng, A. V. Gritsan, W. T. Hung, P. Maksimovic, J. Roskes, U. Sarica, M. Swartz, M. Xiao, C. You, A. Al-bataineh, P. Baringer, A. Bean, S. Boren, J. Bowen, J. Castle, A. Kropivnitskaya, D. Majumder, W. Mcbrayer, M. Murray, C. Rogan, C. Royon, S. Sanders, E. Schmitz, J. D. Tapia Takaki, Q. Wang, A. Ivanov, K. Kaadze, Y. Maravin, A. Modak, A. Mohammadi, L. K. Saini, N. Skhirtladze, F. Rebassoo, D. Wright, A. Baden, O. Baron, A. Belloni, S. C. Eno, Y. Feng, C. Ferraioli, N. J. Hadley, S. Jabeen, G. Y. Jeng, R. G. Kellogg, J. Kunkle, A. C. Mignerey, F. Ricci-Tam, Y. H. Shin, A. Skuja, S. C. Tonwar, D. Abercrombie, B. Allen, V. Azzolini, R. Barbieri, A. Baty, G. Bauer, R. Bi, S. Brandt, W. Busza, I. A. Cali, M. D’Alfonso, Z. Demiragli, G. Gomez Ceballos, M. Goncharov, P. Harris, D. Hsu, M. Hu, Y. Iiyama, G. M. Innocenti, M. Klute, D. Kovalskyi, Y.-J. Lee, A. Levin, P. D. Luckey, B. Maier, A. C. Marini, C. Mcginn, C. Mironov, S. Narayanan, X. Niu, C. Paus, C. Roland, G. Roland, G. S. F. Stephans, K. Sumorok, K. Tatar, D. Velicanu, T. W. Wang, B. Wyslouch, S. Zhaozhong, A. C. Benvenuti, R. M. Chatterjee, A. Evans, P. Hansen, S. Kalafut, Y. Kubota, Z. Lesko, J. Mans, S. Nourbakhsh, N. Ruckstuhl, R. Rusack, J. Turkewitz, M. A. Wadud, J. G. Acosta, S. Oliveros, E. Avdeeva, K. Bloom, D. R. Claes, C. Fangmeier, F. Golf, R. Gonzalez Suarez, R. Kamalieddin, I. Kravchenko, J. Monroy, J. E. Siado, G. R. Snow, B. Stieger, A. Godshalk, C. Harrington, I. Iashvili, D. Nguyen, A. Parker, S. Rappoccio, B. Roozbahani, G. Alverson, E. Barberis, C. Freer, A. Hortiangtham, A. Massironi, D. M. Morse, T. Orimoto, R. Teixeira De Lima, T. Wamorkar, B. Wang, A. Wisecarver, D. Wood, O. Charaf, K. A. Hahn, N. Mucia, N. Odell, M. H. Schmitt, K. Sung, M. Trovato, M. Velasco, R. Bucci, N. Dev, M. Hildreth, K. Hurtado Anampa, C. Jessop, D. J. Karmgard, N. Kellams, K. Lannon, W. Li, N. Loukas, N. Marinelli, F. Meng, C. Mueller, Y. Musienko, M. Planer, A. Reinsvold, R. Ruchti, P. Siddireddy, G. Smith, S. Taroni, M. Wayne, A. Wightman, M. Wolf, A. Woodard, J. Alimena, L. Antonelli, B. Bylsma, L. S. Durkin, S. Flowers, B. Francis, A. Hart, C. Hill, W. Ji, T. Y. Ling, W. Luo, B. L. Winer, H. W. Wulsin, S. Cooperstein, O. Driga, P. Elmer, J. Hardenbrook, P. Hebda, S. Higginbotham, A. Kalogeropoulos, D. Lange, J. Luo, D. Marlow, K. Mei, I. Ojalvo, J. Olsen, C. Palmer, P. Piroué, J. Salfeld-Nebgen, D. Stickland, C. Tully, S. Norberg, A. Barker, V. E. Barnes, S. Das, L. Gutay, M. Jones, A. W. Jung, A. Khatiwada, D. H. Miller, N. Neumeister, C. C. Peng, H. Qiu, J. F. Schulte, J. Sun, F. Wang, R. Xiao, W. Xie, T. Cheng, J. Dolen, N. Parashar, Z. Chen, K. M. Ecklund, S. Freed, F. J. M. Geurts, M. Guilbaud, M. Kilpatrick, B. Michlin, B. P. Padley, J. Roberts, J. Rorie, W. Shi, Z. Tu, J. Zabel, A. Zhang, A. Bodek, P. de Barbaro, R. Demina, Y. t. Duh, T. Ferbel, M. Galanti, A. Garcia-Bellido, J. Han, O. Hindrichs, A. Khukhunaishvili, K. H. Lo, P. Tan, M. Verzetti, R. Ciesielski, K. Goulianos, C. Mesropian, A. Agapitos, J. P. Chou, Y. Gershtein, T. A. Gómez Espinosa, E. Halkiadakis, M. Heindl, E. Hughes, S. Kaplan, R. Kunnawalkam Elayavalli, S. Kyriacou, A. Lath, R. Montalvo, K. Nash, M. Osherson, H. Saka, S. Salur, S. Schnetzer, D. Sheffield, S. Somalwar, R. Stone, S. Thomas, P. Thomassen, M. Walker, A. G. Delannoy, J. Heideman, G. Riley, K. Rose, S. Spanier, K. Thapa, O. Bouhali, A. Castaneda Hernandez, A. Celik, M. Dalchenko, M. De Mattia, A. Delgado, S. Dildick, R. Eusebi, J. Gilmore, T. Huang, T. Kamon, R. Mueller, Y. Pakhotin, R. Patel, A. Perloff, L. Perniè, D. Rathjens, A. Safonov, A. Tatarinov, N. Akchurin, J. Damgov, F. De Guio, P. R. Dudero, J. Faulkner, E. Gurpinar, S. Kunori, K. Lamichhane, T. Mengke, S. Muthumuni, T. Peltola, S. Undleeb, I. Volobouev, S. Greene, A. Gurrola, R. Janjam, W. Johns, C. Maguire, A. Melo, H. Ni, K. Padeken, J. D. Ruiz Alvarez, P. Sheldon, S. Tuo, J. Velkovska, Q. Xu, M. W. Arenton, P. Barria, B. Cox, R. Hirosky, M. Joyce, A. Ledovskoy, H. Li, C. Neu, T. Sinthuprasith, E. Wolfe, F. Xia, R. Harr, P. E. Karchin, N. Poudyal, J. Sturdy, P. Thapa, S. Zaleski, M. Brodski, J. Buchanan, C. Caillol, D. Carlsmith, S. Dasu, L. Dodd, S. Duric, B. Gomber, M. Grothe, M. Herndon, A. Hervé, U. Hussain, P. Klabbers, A. Lanaro, A. Levine, K. Long, R. Loveless, V. Rekovic, T. Ruggles, A. Savin, N. Smith, W. H. Smith, N. Woods, and CMS Collaboration
Subjects: Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Published: 2022
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