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2 results on '"R, Villarruel-Vázquez"'

1. Composition of gut microbiota in obese and normal-weight Mexican school-age children and its association with metabolic traits

Author

B E, López-Contreras, S, Morán-Ramos, R, Villarruel-Vázquez, L, Macías-Kauffer, H, Villamil-Ramírez, P, León-Mimila, J, Vega-Badillo, F, Sánchez-Muñoz, L E, Llanos-Moreno, A, Canizalez-Román, B, Del Río-Navarro, I, Ibarra-González, M, Vela-Amieva, T, Villarreal-Molina, A, Ochoa-Leyva, C A, Aguilar-Salinas, and S, Canizales-Quinteros

Subjects
Male, Pediatric Obesity, Anthropometry, Sequence Analysis, RNA, Glycine, Mass Spectrometry, Diet, Gastrointestinal Microbiome, Feces, RNA, Ribosomal, 16S, Humans, Female, Child, Mexico
Abstract

Childhood obesity is a serious public health problem in Mexico. Adult gut microbiota composition has been linked to obesity, but few studies have addressed the role of gut microbiota in childhood obesity.The aim of this study is to compare gut microbiota composition in obese and normal-weight children and to associate gut microbiota profiles with amino acid serum levels and obesity-related metabolic traits.Microbial taxa relative abundance was determined by 16S rRNA sequencing in 67 normal-weight and 71 obese children aged 6-12 years. Serum amino acid levels were measured by mass spectrometry. Associations between microbiota composition, metabolic parameters and amino acid serum levels were tested.No significant differences in phyla abundances or Firmicutes/Bacteroidetes ratios were observed between normal-weight and obese children. However, Bacteroides eggerthii abundance was significantly higher in obese children and correlated positively with body fat percentage and negatively with insoluble fibre intake. Additionally, Bacteroides plebeius and unclassified Christensenellaceae abundances were significantly higher in normal-weight children. Abundance of both these species correlated negatively with phenylalanine serum levels, a metabolite also found to be associated with obesity in Mexican children.The study identified bacterial species associated with obesity, metabolic complications and amino acid serum levels in Mexican children.

Published
2017

2. Composition of gut microbiota in obese and normal-weight Mexican school-age children and its association with metabolic traits.

Author

López-Contreras BE, Morán-Ramos S, Villarruel-Vázquez R, Macías-Kauffer L, Villamil-Ramírez H, León-Mimila P, Vega-Badillo J, Sánchez-Muñoz F, Llanos-Moreno LE, Canizalez-Román A, Del Río-Navarro B, Ibarra-González I, Vela-Amieva M, Villarreal-Molina T, Ochoa-Leyva A, Aguilar-Salinas CA, and Canizales-Quinteros S

Subjects
Anthropometry methods, Child, Diet, Feces microbiology, Female, Humans, Male, Mass Spectrometry methods, Mexico, RNA, Ribosomal, 16S genetics, Sequence Analysis, RNA methods, Gastrointestinal Microbiome genetics, Glycine blood, Pediatric Obesity microbiology
Abstract

Background: Childhood obesity is a serious public health problem in Mexico. Adult gut microbiota composition has been linked to obesity, but few studies have addressed the role of gut microbiota in childhood obesity., Objectives: The aim of this study is to compare gut microbiota composition in obese and normal-weight children and to associate gut microbiota profiles with amino acid serum levels and obesity-related metabolic traits., Methods: Microbial taxa relative abundance was determined by 16S rRNA sequencing in 67 normal-weight and 71 obese children aged 6-12 years. Serum amino acid levels were measured by mass spectrometry. Associations between microbiota composition, metabolic parameters and amino acid serum levels were tested., Results: No significant differences in phyla abundances or Firmicutes/Bacteroidetes ratios were observed between normal-weight and obese children. However, Bacteroides eggerthii abundance was significantly higher in obese children and correlated positively with body fat percentage and negatively with insoluble fibre intake. Additionally, Bacteroides plebeius and unclassified Christensenellaceae abundances were significantly higher in normal-weight children. Abundance of both these species correlated negatively with phenylalanine serum levels, a metabolite also found to be associated with obesity in Mexican children., Conclusions: The study identified bacterial species associated with obesity, metabolic complications and amino acid serum levels in Mexican children., (© 2017 World Obesity Federation.)

Published
2018
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