1. Split unresponsivess to trinitrophenyl (TNP) determinant.
- Author
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Rózycka, Danuta and Ptak, W.
- Subjects
- *
SERUM , *MICE , *BLOOD proteins , *ANIMAL models in research , *IMMUNOGLOBULINS , *IMMUNOLOGY - Abstract
Contact sensitization by epicutaneous application of picryl chloride causes in mice a significant reduction of the antibody responses to immunogenic TNP-conjugates. This split unresponsiveness is long-lasting. It was found that hapten applied on the skin became attached to the serum proteins and the transfer of such a serum into normal recipients, while not influencing the ability of these animals to become contact-sensitized to PC1, rendered them unable to mount the anti-TNP antibody response, Possible mechanisms of split unresponsiveness to the TNP determinant induced by PC1 treatment are suggested. [ABSTRACT FROM AUTHOR]
- Published
- 1978