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1. Neopterin, IgG, IgA, IgM, and Plasma Volume Changes During Long-distance Running

Author

Gunga Hanns-Christian, Machotta Andreas, Schobersberger Wolfgang, Mittermayr Markus, Kirsch Karl, Koralewski Eberhard, and Röcker Lothar

Subjects
exercise, immune activation, immunoglobulins, neopterin, plasma volume, Crystallography, QD901-999
Abstract

Prolonged physical exercise is associated with several immunological changes, e.g. increase in proinflammatory cytokines, changes in the white blood count etc. Great discrepancies exist with regard to the exercise- induced influence on serum immunoglobulin and neopterin values. One explanation could be the shifts in plasma volume (PV) during and after exercise which might influence plasma concentrations of these parameters. Therefore we investigated the consequences of a marathon race in a homogenous group of experienced runners on plasma volume shifts, serum Immunglobulin and neopterin concentrations. Plasma values with and without correction for plasma volume shifts were compared. PV was significantly diminished after the race (-8.4%) followed by a rise 34h after finish (+8.5%). Serum immunoglobulin IgG, IgA and IgM were increased within the first hours postmarathon and normalized in the recovery period. When chages in PV were considered, only IgA rose significantly. Serum neopterin remained unchanged after the marathon independently whether corrected for PV changes or not. We conclude that the increase in immunoglobulins in our study was mainly the consequence of plasma volume changes. Since neopterin was unchanged we have at least in our study no evidence for exercise-induced activation of the cellular immune system.

Published
2002
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11. Increased core body temperature in astronauts during long-duration space missions

Author

Stahn, Alexander C., primary, Werner, Andreas, additional, Opatz, Oliver, additional, Maggioni, Martina A., additional, Steinach, Mathias, additional, von Ahlefeld, Victoria Weller, additional, Moore, Alan, additional, Crucian, Brian E., additional, Smith, Scott M., additional, Zwart, Sara R., additional, Schlabs, Thomas, additional, Mendt, Stefan, additional, Trippel, Tobias, additional, Koralewski, Eberhard, additional, Koch, Jochim, additional, Choukèr, Alexander, additional, Reitz, Günther, additional, Shang, Peng, additional, Röcker, Lothar, additional, Kirsch, Karl A., additional, and Gunga, Hanns-Christian, additional

Published
2017
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12. Nicht-invasive Bestimmung der Gewebetemperatur der Arbeitsmuskulatur und des Gehirns bei körperlicher Belastung

Author

Röcker, Lothar, Wolfarth, Bernd, Wolff, Roland, Wilfinger, Anke, Röcker, Lothar, Wolfarth, Bernd, Wolff, Roland, and Wilfinger, Anke

Abstract

Hyperthermische Behandlungsverfahren im Bereich der Tumortherapie oder sportmedizinische Fragestellungen zum Einfluss verschiedener Belastungen auf verschiedene Gewebe v.a. die Frage einer möglichen belastungsinduzierten Hyperthermie mit möglicher gesundheitlicher Schädigung usw. verlangen nach einem praktikablen Messverfahren zur Überwachung von Gewebetemperaturen während körperlicher Belastung. In der vorliegenden Arbeit wird der Einfluss körperlicher Belastung bei moderaten Temperaturbedingungen um 21°C auf die Temperaturveränderung zum einen in der Muskulatur, zum anderen im Gehirn untersucht. Es wird eine praktikable Methodik zur Untersuchung von Gewebetemperaturen am Beispiel Muskulatur und Gehirn während bzw. unmittelbar nach körperlicher Belastung mittels Magnetspektroskopie beschrieben. Zur Bestimmung der Gewebetemperatur im M. gastrocnemius während aerober Belastung bei 30 % MVC und anaerober Belastung unter Ischämie bei 60 % MVC wurden an 21 gesunden männlichen Probanden 31P- spektroskopische Untersuchungen Form eines Tretversuches im MRT durchgeführt. Zur Untersuchung der belastungsinduzierten Temperaturentwicklung im Gehirn wurde die 1H-Magnetresonanzspektroskopie (MRS) genutzt. 14 gesunde männliche Probanden wurden während 150 min ohne Flüssigkeitsersatz bei 60 % ihrer individuellen anaeroben Leistungsschwelle auf einem Fahrradergometer belastet. Die Aufzeichnung der Spektren erfolgte zu drei Zeitpunkten prä, post und 3 h post Belastung in drei verschiedenen Voice of Interest (VOI''s) mit einer Grösse von 2 x 2 x 2 cm³= 8ml in der weißen Substanz parietal rechts, in der weißen Substanz parietal links und in der grauen Substanz okzipitoparietal., Method of treatment using hyperthermia in tumor therapy or questions in sports medicine related to the influence of intensive sport activities on different tissue, especially the question of health effects or threat because of the possibility of load induced hyperthermia, need practicable method to measure brain temperature during physical activity. The influence of physical strain on temperature change in differerent tissue, in brain and in muscle, at moderate temperature about 21° C examinated in the present paper. A viable method using MRS for measuring tissue temperature in muscle and brain during physical aktivity resp. directly after load is described. For examination of the influence of different physical load on the local tissue temperature in musculature 31P-MRS was applied. 21 healthy male test person have been examinated using 31P-MRS during aerobic load with 30 % MVC and anaerobic load under ischemia with 60 % MVC . The load, a especially desingned kick experiment, occured directly in the magnetic resonance tomographic unit. 1H-MRS was used for examination of load induced temperature change in brain. 14 healthy male test person were loaded on cycle-ergometer during 150-min without liquid substitute with 60 % individual anaerobic threshold. MR-spectra observed in three different Voice of Interest (VOI''s) sized 2 x 2 x 2 cm³: grey substance occipitoparietal, white substance partietal on the right and white substance parietal on the left.

Published
2016

13. Wertigkeit ausgewählter Eisenstoffwechselparameter im Ausdauersport

Author

Röcker, Lothar, Wolff, Roland, Krüll, Matthias, Brachmann, Steffi, Röcker, Lothar, Wolff, Roland, Krüll, Matthias, and Brachmann, Steffi

Abstract

Einleitung: Eisenmangel ist ein häufiges Problem bei Ausdauersportlern, da dieser die Leistungsfähigkeit einschränken und zu einer Blutanämie führen kann. Von den klassischen Eisenstoffwechselparametern sind nur wenige geeignet, den tatsächlichen Eisenstatus anzuzeigen, da sie durch sportliche Aktivität per se beeinflusst werden können. In der Studie wird die Wertigkeit moderner Eisenstoffwechselparameter im Ausdauersport untersucht. Ergebnisse und Diskussion: Der Hämoglobingehalt der Retikulozyten (CHr) und der prozentuale Anteil der hypochromen Erythrozyten (% HYPO) bleiben als moderne Parameter der Eisenstoffwechseldiagnostik auch nach regenerativen, extensiven sowie intensiven Ausdauerbelastungen konstant. Sie zeigen somit unbeeinflusst von der (Ausdauer-)Sportart als auch von der Belastungsdauer und –intensität die aktuelle Eisenversorgung der Erythropoese im Knochenmark an. Als Monitoringparameter im Rahmen einer Eisensubstitution sind der CHr sowie der prozentuale Anteil hypochromer Retikulozyten sensible Parameter, mit denen sich schnell und zuverlässig die Effektivität einer oralen Eisensubstitution nachweisen lässt. Der Eisenstatus kann durch die alleinige Bestimmung des CHr bzw. des % HYPO nicht exakt ermittelt werden. Im Gegensatz zum Einsatz bei klinischen Fragestellungen können sie zu diesem Zeitpunkt in der Sportmedizin allenfalls nur ein ergänzender Parameter in der Differentialdiagnostik eines Eisenmangels sein. Die für Ausdauersportler ermittelten Referenzwerte liegen bei 28,8-35,9 pg für den CHr und bei 0-0,5 % für die hypochromen Erythrozyten. Ein belastungsbedingter Anstieg des Eisen-regulierenden Hormons Hepcidin könnte auf Grund seiner inhibitorischen Wirkung auf die intestinale Eisenabsorption sowie auf die Freisetzung von Eisen aus den Makrophagen zur Entwicklung von Eisenmangel-zuständen führen. Die Entwicklung von Hepcidin-Antagonisten könnte in Zukunft therapeutische Anwendungen finden., Introduction: Athletes are commonly diagnosed with iron deficiency, particularly those involved in endurance sports. It often not only decreases athletic performance but also contributes to the development of anaemia. Many biochemical markers are used to evaluate body iron stores but some of them are affected by physical exercises. This study was designed to investigate new haematological parameters in endurance athletes. Results and discussion: Reticulocyte hemoglobin content (CHr) and percentage of hypochromic red cells (% HYPO) were highly stable in athletes subjected to varying physical loads. Furthermore, they were neither affected by different forms of endurance sports nor by their duration and intensity. These modern indices are able to reflect the availability of iron during erythropoiesis at all times. In the early prediction of response to oral iron supplementation, the reticulocyte indices CHr and % HYPOr (percentage of hypochromic reticulocytes) are the most sensitive parameters. However, it is not possible to assess the iron status in athletes by CHr and % HYPO alone. In contrast to other clinical cases they can only be an additional parameter in the differential diagnosis of iron deficiency. The calculated reference range for endurance athletes are 28,8 - 35,9 pg for CHr and 0-0,5 % for % HYPO. As the iron-regulating hormone hepcidin is inhibiting the absorption of iron from the diet at the site of the duodenal enterocytes and blocking the release of iron from macrophages that have collected senescent erythrocytes, an exercise induced up-regulation of hepcidin activity might potentially be a new mechanism causing iron deficiency in athletes. Therefore, the development of hepcidin antagonists could prove to be helpful with regard to therapeutic utilization.

Published
2011

24. Body size and body volume distribution in two sauropods from the Upper Jurassic of Tendaguru (Tanzania)

Author

Gunga, Hanns‐Christian, Kirsch, Karl, Rittweger, Jörn, Röcker, Lothar, Clarke, Andrew, Albertz, Jörg, Wiedemann, Albert, Mokry, Sascha, Suthau, Tim, Wehr, Aloys, Heinrich, Wolf‐Dieter, and Schultze, Hans‐Peter

Abstract

Allometric equations are often based on the body mass of an animal because body mass determines many physiological functions. This should also hold for Brachiosaurus brancaiand Dicraeosaurus hansemanni, two sauropods from the Upper Jurassic of Tendaguru/Tanzania (East Africa). Widely divergent estimates of body mass for the same specimen can be found in the literature for these two sauropods.

Published
1999
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25. Combined beta1-adrenoceptor blockade andor beta2- or beta12adrenoceptor stimulation as treatment of essential hypertension

Author

Schulte, Karl-Ludwig, Meyer-Sabellek, Wolfgang, Thiede, Hans-Michael, Röcker, Lothar, and Gotzen, Reinhard

Abstract

Single and combined therapy with terbutaline (10 mg/day) and metoprolol (200 mg/day) and single therapy with orciprenaline (30 mg/day) were assessed over 8 weeks in a total of 45 patients with essential hypertension. Blood pressure at rest was comparably reduced by metoprolol + terbutaline and metoprolol alone, but with terbutaline and orciprenaline only after 4 weeks. The responder rates (±10 reduction in diastolic blood pressure) at rest were 58 (metoprolol + terbutaline), 63 (metoprolol) and significantly lower with terbutaline alone at 42 and orciprenaline alone at 45. The heart rate was affected only by metoprolol monotherapy, which caused a significant decrease. The β-adrenoceptor stimulators terbutaline and orciprenaline in the chosen doses slightly decreased blood pressure and did not increase the heart rate. Metoprolol was an effective antihypertensive agent but decreased the heart rate. Under combined therapy with terbutaline, there was no additional blood pressure decrease, but the heart rate remained unaffected.

Published
1988

29. Die körperliche Leistungsfähigkeit in der Höhe

Author

Åstrand, P.-O., Hollmann, Wildor, editor, Åstrand, Per-Olof, editor, Bouchard, Claude, editor, Donike, Manfred, editor, Drews, Adolf, editor, Groh, Herbert, editor, Halhuber, Max J., editor, Haralambie, Georg, editor, Hofmann, Hubert, editor, Karlsson, Jann, editor, Keul, Josef, editor, Klauck, Jürgen, editor, Mellerowicz, Harald, editor, Milz, Helmut P., editor, Röcker, Lothar, editor, Rost, Richard, editor, Rujbr, Rostislav, editor, Saltin, Bengt, editor, Schmidt, Josef, editor, Schoberth, Hanns, editor, Seliger, Václav, editor, Stegemann, Jürgen, editor, Stoboy, Hans, editor, Strydom, Nicolaas B., editor, Thibault, Marie-Christine, editor, and Wyndham, Cyril H., editor

Published
1977
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30. Herz und Kreislauf im Sport

Author

Stegemann, J., Hollmann, Wildor, editor, Åstrand, Per-Olof, editor, Bouchard, Claude, editor, Donike, Manfred, editor, Drews, Adolf, editor, Groh, Herbert, editor, Halhuber, Max J., editor, Haralambie, Georg, editor, Hofmann, Hubert, editor, Karlsson, Jann, editor, Keul, Josef, editor, Klauck, Jürgen, editor, Mellerowicz, Harald, editor, Milz, Helmut P., editor, Röcker, Lothar, editor, Rost, Richard, editor, Rujbr, Rostislav, editor, Saltin, Bengt, editor, Schmidt, Josef, editor, Schoberth, Hanns, editor, Seliger, Václav, editor, Stegemann, Jürgen, editor, Stoboy, Hans, editor, Strydom, Nicolaas B., editor, Thibault, Marie-Christine, editor, and Wyndham, Cyril H., editor

Published
1977
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31. Der Einfluß körperlicher Aktivität auf das Blut

Author

Röcker, L., Hollmann, Wildor, editor, Åstrand, Per-Olof, editor, Bouchard, Claude, editor, Donike, Manfred, editor, Drews, Adolf, editor, Groh, Herbert, editor, Halhuber, Max J., editor, Haralambie, Georg, editor, Hofmann, Hubert, editor, Karlsson, Jann, editor, Keul, Josef, editor, Klauck, Jürgen, editor, Mellerowicz, Harald, editor, Milz, Helmut P., editor, Röcker, Lothar, editor, Rost, Richard, editor, Rujbr, Rostislav, editor, Saltin, Bengt, editor, Schmidt, Josef, editor, Schoberth, Hanns, editor, Seliger, Václav, editor, Stegemann, Jürgen, editor, Stoboy, Hans, editor, Strydom, Nicolaas B., editor, Thibault, Marie-Christine, editor, and Wyndham, Cyril H., editor

Published
1977
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32. Energiestoffwechsel und körperliche Leistung

Author

Keul, J., Haralambie, G., Hollmann, Wildor, editor, Åstrand, Per-Olof, editor, Bouchard, Claude, editor, Donike, Manfred, editor, Drews, Adolf, editor, Groh, Herbert, editor, Halhuber, Max J., editor, Haralambie, Georg, editor, Hofmann, Hubert, editor, Karlsson, Jann, editor, Keul, Josef, editor, Klauck, Jürgen, editor, Mellerowicz, Harald, editor, Milz, Helmut P., editor, Röcker, Lothar, editor, Rost, Richard, editor, Rujbr, Rostislav, editor, Saltin, Bengt, editor, Schmidt, Josef, editor, Schoberth, Hanns, editor, Seliger, Václav, editor, Stegemann, Jürgen, editor, Stoboy, Hans, editor, Strydom, Nicolaas B., editor, Thibault, Marie-Christine, editor, and Wyndham, Cyril H., editor

Published
1977
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33. Lungenfunktion, Atmung und Gasstoffwechsel im Sport

Author

Hollmann, W., Hollmann, Wildor, editor, Åstrand, Per-Olof, editor, Bouchard, Claude, editor, Donike, Manfred, editor, Drews, Adolf, editor, Groh, Herbert, editor, Halhuber, Max J., editor, Haralambie, Georg, editor, Hofmann, Hubert, editor, Karlsson, Jann, editor, Keul, Josef, editor, Klauck, Jürgen, editor, Mellerowicz, Harald, editor, Milz, Helmut P., editor, Röcker, Lothar, editor, Rost, Richard, editor, Rujbr, Rostislav, editor, Saltin, Bengt, editor, Schmidt, Josef, editor, Schoberth, Hanns, editor, Seliger, Václav, editor, Stegemann, Jürgen, editor, Stoboy, Hans, editor, Strydom, Nicolaas B., editor, Thibault, Marie-Christine, editor, and Wyndham, Cyril H., editor

Published
1977
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34. Die Ernährung des Sportlers

Author

Saltin, B., Karlsson, J., Hollmann, Wildor, editor, Åstrand, Per-Olof, editor, Bouchard, Claude, editor, Donike, Manfred, editor, Drews, Adolf, editor, Groh, Herbert, editor, Halhuber, Max J., editor, Haralambie, Georg, editor, Hofmann, Hubert, editor, Karlsson, Jann, editor, Keul, Josef, editor, Klauck, Jürgen, editor, Mellerowicz, Harald, editor, Milz, Helmut P., editor, Röcker, Lothar, editor, Rost, Richard, editor, Rujbr, Rostislav, editor, Saltin, Bengt, editor, Schmidt, Josef, editor, Schoberth, Hanns, editor, Seliger, Václav, editor, Stegemann, Jürgen, editor, Stoboy, Hans, editor, Strydom, Nicolaas B., editor, Thibault, Marie-Christine, editor, and Wyndham, Cyril H., editor

Published
1977
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35. Sport und körperliches Training als Mittel der Präventivmedizin in der Kardiologie

Author

Hollmann, W., Hollmann, Wildor, editor, Åstrand, Per-Olof, editor, Bouchard, Claude, editor, Donike, Manfred, editor, Drews, Adolf, editor, Groh, Herbert, editor, Halhuber, Max J., editor, Haralambie, Georg, editor, Hofmann, Hubert, editor, Karlsson, Jann, editor, Keul, Josef, editor, Klauck, Jürgen, editor, Mellerowicz, Harald, editor, Milz, Helmut P., editor, Röcker, Lothar, editor, Rost, Richard, editor, Rujbr, Rostislav, editor, Saltin, Bengt, editor, Schmidt, Josef, editor, Schoberth, Hanns, editor, Seliger, Václav, editor, Stegemann, Jürgen, editor, Stoboy, Hans, editor, Strydom, Nicolaas B., editor, Thibault, Marie-Christine, editor, and Wyndham, Cyril H., editor

Published
1977
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36. Neuromuskuläre Funktion und körperliche Leistung

Author

Stoboy, H., Hollmann, Wildor, editor, Åstrand, Per-Olof, editor, Bouchard, Claude, editor, Donike, Manfred, editor, Drews, Adolf, editor, Groh, Herbert, editor, Halhuber, Max J., editor, Haralambie, Georg, editor, Hofmann, Hubert, editor, Karlsson, Jann, editor, Keul, Josef, editor, Klauck, Jürgen, editor, Mellerowicz, Harald, editor, Milz, Helmut P., editor, Röcker, Lothar, editor, Rost, Richard, editor, Rujbr, Rostislav, editor, Saltin, Bengt, editor, Schmidt, Josef, editor, Schoberth, Hanns, editor, Seliger, Václav, editor, Stegemann, Jürgen, editor, Stoboy, Hans, editor, Strydom, Nicolaas B., editor, Thibault, Marie-Christine, editor, and Wyndham, Cyril H., editor

Published
1977
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37. Sportverletzungen

Author

Schoberth, H., Hollmann, Wildor, editor, Åstrand, Per-Olof, editor, Bouchard, Claude, editor, Donike, Manfred, editor, Drews, Adolf, editor, Groh, Herbert, editor, Halhuber, Max J., editor, Haralambie, Georg, editor, Hofmann, Hubert, editor, Karlsson, Jann, editor, Keul, Josef, editor, Klauck, Jürgen, editor, Mellerowicz, Harald, editor, Milz, Helmut P., editor, Röcker, Lothar, editor, Rost, Richard, editor, Rujbr, Rostislav, editor, Saltin, Bengt, editor, Schmidt, Josef, editor, Schoberth, Hanns, editor, Seliger, Václav, editor, Stegemann, Jürgen, editor, Stoboy, Hans, editor, Strydom, Nicolaas B., editor, Thibault, Marie-Christine, editor, and Wyndham, Cyril H., editor

Published
1977
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38. Das Sportherz

Author

Rost, R., Hollmann, Wildor, editor, Åstrand, Per-Olof, editor, Bouchard, Claude, editor, Donike, Manfred, editor, Drews, Adolf, editor, Groh, Herbert, editor, Halhuber, Max J., editor, Haralambie, Georg, editor, Hofmann, Hubert, editor, Karlsson, Jann, editor, Keul, Josef, editor, Klauck, Jürgen, editor, Mellerowicz, Harald, editor, Milz, Helmut P., editor, Röcker, Lothar, editor, Rost, Richard, editor, Rujbr, Rostislav, editor, Saltin, Bengt, editor, Schmidt, Josef, editor, Schoberth, Hanns, editor, Seliger, Václav, editor, Stegemann, Jürgen, editor, Stoboy, Hans, editor, Strydom, Nicolaas B., editor, Thibault, Marie-Christine, editor, and Wyndham, Cyril H., editor

Published
1977
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39. Höheres Alter und Sport

Author

Schmidt, J., Hollmann, Wildor, editor, Åstrand, Per-Olof, editor, Bouchard, Claude, editor, Donike, Manfred, editor, Drews, Adolf, editor, Groh, Herbert, editor, Halhuber, Max J., editor, Haralambie, Georg, editor, Hofmann, Hubert, editor, Karlsson, Jann, editor, Keul, Josef, editor, Klauck, Jürgen, editor, Mellerowicz, Harald, editor, Milz, Helmut P., editor, Röcker, Lothar, editor, Rost, Richard, editor, Rujbr, Rostislav, editor, Saltin, Bengt, editor, Schmidt, Josef, editor, Schoberth, Hanns, editor, Seliger, Václav, editor, Stegemann, Jürgen, editor, Stoboy, Hans, editor, Strydom, Nicolaas B., editor, Thibault, Marie-Christine, editor, and Wyndham, Cyril H., editor

Published
1977
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40. Körperliche Arbeit bei hoher Temperatur

Author

Wyndham, C. H., Strydom, N. B., Hollmann, Wildor, editor, Åstrand, Per-Olof, editor, Bouchard, Claude, editor, Donike, Manfred, editor, Drews, Adolf, editor, Groh, Herbert, editor, Halhuber, Max J., editor, Haralambie, Georg, editor, Hofmann, Hubert, editor, Karlsson, Jann, editor, Keul, Josef, editor, Klauck, Jürgen, editor, Mellerowicz, Harald, editor, Milz, Helmut P., editor, Röcker, Lothar, editor, Rost, Richard, editor, Rujbr, Rostislav, editor, Saltin, Bengt, editor, Schmidt, Josef, editor, Schoberth, Hanns, editor, Seliger, Václav, editor, Stegemann, Jürgen, editor, Stoboy, Hans, editor, Strydom, Nicolaas B., editor, Thibault, Marie-Christine, editor, and Wyndham, Cyril H., editor

Published
1977
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41. Doping, oder das Pharmakon im Sport

Author

Donike, M., Hollmann, Wildor, editor, Åstrand, Per-Olof, editor, Bouchard, Claude, editor, Donike, Manfred, editor, Drews, Adolf, editor, Groh, Herbert, editor, Halhuber, Max J., editor, Haralambie, Georg, editor, Hofmann, Hubert, editor, Karlsson, Jann, editor, Keul, Josef, editor, Klauck, Jürgen, editor, Mellerowicz, Harald, editor, Milz, Helmut P., editor, Röcker, Lothar, editor, Rost, Richard, editor, Rujbr, Rostislav, editor, Saltin, Bengt, editor, Schmidt, Josef, editor, Schoberth, Hanns, editor, Seliger, Václav, editor, Stegemann, Jürgen, editor, Stoboy, Hans, editor, Strydom, Nicolaas B., editor, Thibault, Marie-Christine, editor, and Wyndham, Cyril H., editor

Published
1977
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42. Bewegungstherapie in der Rehabilitation von Herz-Kreislauf-Kranken

Author

Drews, A., Halhuber, M. J., Hofmann, H., Milz, H., Rujbr, R., Hollmann, Wildor, editor, Åstrand, Per-Olof, editor, Bouchard, Claude, editor, Donike, Manfred, editor, Drews, Adolf, editor, Groh, Herbert, editor, Halhuber, Max J., editor, Haralambie, Georg, editor, Hofmann, Hubert, editor, Karlsson, Jann, editor, Keul, Josef, editor, Klauck, Jürgen, editor, Mellerowicz, Harald, editor, Milz, Helmut P., editor, Röcker, Lothar, editor, Rost, Richard, editor, Rujbr, Rostislav, editor, Saltin, Bengt, editor, Schmidt, Josef, editor, Schoberth, Hanns, editor, Seliger, Václav, editor, Stegemann, Jürgen, editor, Stoboy, Hans, editor, Strydom, Nicolaas B., editor, Thibault, Marie-Christine, editor, and Wyndham, Cyril H., editor

Published
1977
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43. Training

Author

Mellerowicz, H., Hollmann, Wildor, editor, Åstrand, Per-Olof, editor, Bouchard, Claude, editor, Donike, Manfred, editor, Drews, Adolf, editor, Groh, Herbert, editor, Halhuber, Max J., editor, Haralambie, Georg, editor, Hofmann, Hubert, editor, Karlsson, Jann, editor, Keul, Josef, editor, Klauck, Jürgen, editor, Mellerowicz, Harald, editor, Milz, Helmut P., editor, Röcker, Lothar, editor, Rost, Richard, editor, Rujbr, Rostislav, editor, Saltin, Bengt, editor, Schmidt, Josef, editor, Schoberth, Hanns, editor, Seliger, Václav, editor, Stegemann, Jürgen, editor, Stoboy, Hans, editor, Strydom, Nicolaas B., editor, Thibault, Marie-Christine, editor, and Wyndham, Cyril H., editor

Published
1977
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44. Biomechanik des Sports

Author

Groh, H., Klauck, J., Hollmann, Wildor, editor, Åstrand, Per-Olof, editor, Bouchard, Claude, editor, Donike, Manfred, editor, Drews, Adolf, editor, Groh, Herbert, editor, Halhuber, Max J., editor, Haralambie, Georg, editor, Hofmann, Hubert, editor, Karlsson, Jann, editor, Keul, Josef, editor, Klauck, Jürgen, editor, Mellerowicz, Harald, editor, Milz, Helmut P., editor, Röcker, Lothar, editor, Rost, Richard, editor, Rujbr, Rostislav, editor, Saltin, Bengt, editor, Schmidt, Josef, editor, Schoberth, Hanns, editor, Seliger, Václav, editor, Stegemann, Jürgen, editor, Stoboy, Hans, editor, Strydom, Nicolaas B., editor, Thibault, Marie-Christine, editor, and Wyndham, Cyril H., editor

Published
1977
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45. Jugend und Sport

Author

Bouchard, C., Thibault, M.-Chr., Hollmann, Wildor, editor, Åstrand, Per-Olof, editor, Bouchard, Claude, editor, Donike, Manfred, editor, Drews, Adolf, editor, Groh, Herbert, editor, Halhuber, Max J., editor, Haralambie, Georg, editor, Hofmann, Hubert, editor, Karlsson, Jann, editor, Keul, Josef, editor, Klauck, Jürgen, editor, Mellerowicz, Harald, editor, Milz, Helmut P., editor, Röcker, Lothar, editor, Rost, Richard, editor, Rujbr, Rostislav, editor, Saltin, Bengt, editor, Schmidt, Josef, editor, Schoberth, Hanns, editor, Seliger, Václav, editor, Stegemann, Jürgen, editor, Stoboy, Hans, editor, Strydom, Nicolaas B., editor, Thibault, Marie-Christine, editor, and Wyndham, Cyril H., editor

Published
1977
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46. Frau und Sport

Author

Seliger, V., Hollmann, Wildor, editor, Åstrand, Per-Olof, editor, Bouchard, Claude, editor, Donike, Manfred, editor, Drews, Adolf, editor, Groh, Herbert, editor, Halhuber, Max J., editor, Haralambie, Georg, editor, Hofmann, Hubert, editor, Karlsson, Jann, editor, Keul, Josef, editor, Klauck, Jürgen, editor, Mellerowicz, Harald, editor, Milz, Helmut P., editor, Röcker, Lothar, editor, Rost, Richard, editor, Rujbr, Rostislav, editor, Saltin, Bengt, editor, Schmidt, Josef, editor, Schoberth, Hanns, editor, Seliger, Václav, editor, Stegemann, Jürgen, editor, Stoboy, Hans, editor, Strydom, Nicolaas B., editor, Thibault, Marie-Christine, editor, and Wyndham, Cyril H., editor

Published
1977
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47. Nicht-invasive Bestimmung der Gewebetemperatur der Arbeitsmuskulatur und des Gehirns bei körperlicher Belastung

Author

Wilfinger, Anke, Röcker, Lothar, Wolfarth, Bernd, and Wolff, Roland

Subjects
körperliche Belastung, 796 Sport, muscle, brain, XH 3304, tissue temperature, 50 Sport, Spiele, Magnetresonanzspektroskopie, magnetic resonance spectroscopy, Muskel, physical strain, ZX 9309, Gewebetemperatur, ddc:796, Gehirn
Abstract

Hyperthermische Behandlungsverfahren im Bereich der Tumortherapie oder sportmedizinische Fragestellungen zum Einfluss verschiedener Belastungen auf verschiedene Gewebe v.a. die Frage einer möglichen belastungsinduzierten Hyperthermie mit möglicher gesundheitlicher Schädigung usw. verlangen nach einem praktikablen Messverfahren zur Überwachung von Gewebetemperaturen während körperlicher Belastung. In der vorliegenden Arbeit wird der Einfluss körperlicher Belastung bei moderaten Temperaturbedingungen um 21°C auf die Temperaturveränderung zum einen in der Muskulatur, zum anderen im Gehirn untersucht. Es wird eine praktikable Methodik zur Untersuchung von Gewebetemperaturen am Beispiel Muskulatur und Gehirn während bzw. unmittelbar nach körperlicher Belastung mittels Magnetspektroskopie beschrieben. Zur Bestimmung der Gewebetemperatur im M. gastrocnemius während aerober Belastung bei 30 % MVC und anaerober Belastung unter Ischämie bei 60 % MVC wurden an 21 gesunden männlichen Probanden 31P- spektroskopische Untersuchungen Form eines Tretversuches im MRT durchgeführt. Zur Untersuchung der belastungsinduzierten Temperaturentwicklung im Gehirn wurde die 1H-Magnetresonanzspektroskopie (MRS) genutzt. 14 gesunde männliche Probanden wurden während 150 min ohne Flüssigkeitsersatz bei 60 % ihrer individuellen anaeroben Leistungsschwelle auf einem Fahrradergometer belastet. Die Aufzeichnung der Spektren erfolgte zu drei Zeitpunkten prä, post und 3 h post Belastung in drei verschiedenen Voice of Interest (VOI''s) mit einer Grösse von 2 x 2 x 2 cm³= 8ml in der weißen Substanz parietal rechts, in der weißen Substanz parietal links und in der grauen Substanz okzipitoparietal. Method of treatment using hyperthermia in tumor therapy or questions in sports medicine related to the influence of intensive sport activities on different tissue, especially the question of health effects or threat because of the possibility of load induced hyperthermia, need practicable method to measure brain temperature during physical activity. The influence of physical strain on temperature change in differerent tissue, in brain and in muscle, at moderate temperature about 21° C examinated in the present paper. A viable method using MRS for measuring tissue temperature in muscle and brain during physical aktivity resp. directly after load is described. For examination of the influence of different physical load on the local tissue temperature in musculature 31P-MRS was applied. 21 healthy male test person have been examinated using 31P-MRS during aerobic load with 30 % MVC and anaerobic load under ischemia with 60 % MVC . The load, a especially desingned kick experiment, occured directly in the magnetic resonance tomographic unit. 1H-MRS was used for examination of load induced temperature change in brain. 14 healthy male test person were loaded on cycle-ergometer during 150-min without liquid substitute with 60 % individual anaerobic threshold. MR-spectra observed in three different Voice of Interest (VOI''s) sized 2 x 2 x 2 cm³: grey substance occipitoparietal, white substance partietal on the right and white substance parietal on the left.

Published
2016

48. Wertigkeit ausgewählter Eisenstoffwechselparameter im Ausdauersport

Author

Brachmann, Steffi, Röcker, Lothar, Wolff, Roland, and Krüll, Matthias

Subjects
endurance sports, iron deficiency, reticulocyte hemoglobin content, Eisenmangel, percentage of hypochromic red blood cells, Hepcidin, 610 Medizin, ddc:610, Ausdauersport, 33 Medizin, prozentualer Anteil hypochromer Erythrozyten, ZX 9400, Hämoglobingehalt der Retikulozyten
Abstract

Einleitung: Eisenmangel ist ein häufiges Problem bei Ausdauersportlern, da dieser die Leistungsfähigkeit einschränken und zu einer Blutanämie führen kann. Von den klassischen Eisenstoffwechselparametern sind nur wenige geeignet, den tatsächlichen Eisenstatus anzuzeigen, da sie durch sportliche Aktivität per se beeinflusst werden können. In der Studie wird die Wertigkeit moderner Eisenstoffwechselparameter im Ausdauersport untersucht. Ergebnisse und Diskussion: Der Hämoglobingehalt der Retikulozyten (CHr) und der prozentuale Anteil der hypochromen Erythrozyten (% HYPO) bleiben als moderne Parameter der Eisenstoffwechseldiagnostik auch nach regenerativen, extensiven sowie intensiven Ausdauerbelastungen konstant. Sie zeigen somit unbeeinflusst von der (Ausdauer-)Sportart als auch von der Belastungsdauer und –intensität die aktuelle Eisenversorgung der Erythropoese im Knochenmark an. Als Monitoringparameter im Rahmen einer Eisensubstitution sind der CHr sowie der prozentuale Anteil hypochromer Retikulozyten sensible Parameter, mit denen sich schnell und zuverlässig die Effektivität einer oralen Eisensubstitution nachweisen lässt. Der Eisenstatus kann durch die alleinige Bestimmung des CHr bzw. des % HYPO nicht exakt ermittelt werden. Im Gegensatz zum Einsatz bei klinischen Fragestellungen können sie zu diesem Zeitpunkt in der Sportmedizin allenfalls nur ein ergänzender Parameter in der Differentialdiagnostik eines Eisenmangels sein. Die für Ausdauersportler ermittelten Referenzwerte liegen bei 28,8-35,9 pg für den CHr und bei 0-0,5 % für die hypochromen Erythrozyten. Ein belastungsbedingter Anstieg des Eisen-regulierenden Hormons Hepcidin könnte auf Grund seiner inhibitorischen Wirkung auf die intestinale Eisenabsorption sowie auf die Freisetzung von Eisen aus den Makrophagen zur Entwicklung von Eisenmangel-zuständen führen. Die Entwicklung von Hepcidin-Antagonisten könnte in Zukunft therapeutische Anwendungen finden. Introduction: Athletes are commonly diagnosed with iron deficiency, particularly those involved in endurance sports. It often not only decreases athletic performance but also contributes to the development of anaemia. Many biochemical markers are used to evaluate body iron stores but some of them are affected by physical exercises. This study was designed to investigate new haematological parameters in endurance athletes. Results and discussion: Reticulocyte hemoglobin content (CHr) and percentage of hypochromic red cells (% HYPO) were highly stable in athletes subjected to varying physical loads. Furthermore, they were neither affected by different forms of endurance sports nor by their duration and intensity. These modern indices are able to reflect the availability of iron during erythropoiesis at all times. In the early prediction of response to oral iron supplementation, the reticulocyte indices CHr and % HYPOr (percentage of hypochromic reticulocytes) are the most sensitive parameters. However, it is not possible to assess the iron status in athletes by CHr and % HYPO alone. In contrast to other clinical cases they can only be an additional parameter in the differential diagnosis of iron deficiency. The calculated reference range for endurance athletes are 28,8 - 35,9 pg for CHr and 0-0,5 % for % HYPO. As the iron-regulating hormone hepcidin is inhibiting the absorption of iron from the diet at the site of the duodenal enterocytes and blocking the release of iron from macrophages that have collected senescent erythrocytes, an exercise induced up-regulation of hepcidin activity might potentially be a new mechanism causing iron deficiency in athletes. Therefore, the development of hepcidin antagonists could prove to be helpful with regard to therapeutic utilization.

Published
2011

49. Influence of endurance exercise (triathlon) on circulating transferrin receptors and other indicators of iron status in female athletes.

Author

Röcker L, Hinz K, Holland K, Gunga HC, Vogelgesang J, and Kiesewetter H

Subjects
Adult, Bicycling, Biomarkers blood, Female, Humans, Rest, Swimming, Haptoglobins metabolism, Iron metabolism, Physical Endurance, Receptors, Transferrin blood, Sports, Transferrin metabolism
Abstract

Numerous reports have described a poor iron status in female endurance athletes. However, the traditionally applied indicators of iron status (hemoglobin, ferritin, transferrin) may not truly reflect the iron status. Therefore we studied the newly developed soluble transferrin receptor and other indicators of iron status in twelve female endurance athletes before and after a triathlon race. Resting values showed a poor iron status in the participants of the race. Serum TfR concentration increased slightly after the race. However, if the values are corrected for hemoconcentration no change could be found. Hemoglobin, serum ferritin and transferrin values were increased after the race.

Published
2002

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