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3. Ion-induced transient potential fluctuations facilitate pore formation and cation transport through lipid membranes

Author

Roesel, David, Eremchev, Maksim, Poojari, Chetan S., Hub, Jochen S., and Roke, Sylvie

Subjects
Condensed Matter - Soft Condensed Matter, Physics - Chemical Physics
Abstract

Unassisted ion transport through lipid membranes plays a crucial role in many cell functions without which life would not be possible, yet the precise mechanism behind the process remains unknown due to its molecular complexity. Here, we demonstrate a direct link between membrane potential fluctuations and divalent ion transport. High-throughput wide-field second harmonic (SH) microscopy shows that membrane potential fluctuations are universally found in lipid bilayer systems. Molecular dynamics simulations reveal that such variations in membrane potential reduce the free energy cost of transient pore formation and increase the ion flux across an open pore. These transient pores can act as conduits for ion transport, which we SH image for a series of divalent cations (Cu$^{2+}$, Ca$^{2+}$, Ba$^{2+}$, Mg$^{2+}$) passing through GUV membranes. Combining the experimental and computational results, we show that permeation through pores formed via an ion-induced electrostatic field is a viable mechanism for unassisted ion transport., Comment: 8 pages, 2 figures

Published
2022

9. SaCoFa: Semantics-aware Control-flow Anonymization for Process Mining

Author

Fahrenkrog-Petersen, Stephan A., Kabierski, Martin, Rösel, Fabian, van der Aa, Han, and Weidlich, Matthias

Subjects
Computer Science - Databases, Computer Science - Artificial Intelligence, Computer Science - Cryptography and Security, Computer Science - Machine Learning
Abstract

Privacy-preserving process mining enables the analysis of business processes using event logs, while giving guarantees on the protection of sensitive information on process stakeholders. To this end, existing approaches add noise to the results of queries that extract properties of an event log, such as the frequency distribution of trace variants, for analysis.Noise insertion neglects the semantics of the process, though, and may generate traces not present in the original log. This is problematic. It lowers the utility of the published data and makes noise easily identifiable, as some traces will violate well-known semantic constraints.In this paper, we therefore argue for privacy preservation that incorporates a process semantics. For common trace-variant queries, we show how, based on the exponential mechanism, semantic constraints are incorporated to ensure differential privacy of the query result. Experiments demonstrate that our semantics-aware anonymization yields event logs of significantly higher utility than existing approaches.

Published
2021

10. A Distance Measure for Privacy-preserving Process Mining based on Feature Learning

Author

Rösel, Fabian, Fahrenkrog-Petersen, Stephan A., van der Aa, Han, and Weidlich, Matthias

Subjects
Computer Science - Cryptography and Security, Computer Science - Artificial Intelligence, Computer Science - Machine Learning, H.4
Abstract

To enable process analysis based on an event log without compromising the privacy of individuals involved in process execution, a log may be anonymized. Such anonymization strives to transform a log so that it satisfies provable privacy guarantees, while largely maintaining its utility for process analysis. Existing techniques perform anonymization using simple, syntactic measures to identify suitable transformation operations. This way, the semantics of the activities referenced by the events in a trace are neglected, potentially leading to transformations in which events of unrelated activities are merged. To avoid this and incorporate the semantics of activities during anonymization, we propose to instead incorporate a distance measure based on feature learning. Specifically, we show how embeddings of events enable the definition of a distance measure for traces to guide event log anonymization. Our experiments with real-world data indicate that anonymization using this measure, compared to a syntactic one, yields logs that are closer to the original log in various dimensions and, hence, have higher utility for process analysis., Comment: Accepted for 17th International Workshop on Business Process Intelligence

Published
2021

16. Glossary

Author

Lehner, Lisa, Rösel, Charlotte, Maggi, Stefania, Series Editor, Smith, Lee, editor, and Grabovac, Igor, editor

Published
2023
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17. Towards Institutionalization of One Health in Eastern and Southern Africa

Author

Richards, Shauna, Knight-Jones, Theo, Angombe, Simon, Becker, John, Bukachi, Salome A., Chirenda, Joconiah, Araujo, Lucinda, Nys, Hélène, Desta, Hiwot, Fafetine, Jose, Fevre, Eric, Freeman, Rachel, Grace, Delia, Hamoonga, Raymond, Hared, Yusuf Abdi, Hassim, Ayesha, Iraki, Bibiana, Justine, Okello, Kaba, Mirgissa, Kankya, Clovice, Karembu, Margaret, Kimaro, Esther G., Lukuyu, Ben, Matope, Gift, Mor, Siobhan M., Munyeme, Musso, Mutua, Florence, Mtegha, Chiku, Patel, Ekta, Pfukenyi, Davies, Pule-Meulenberg, Flora, Roesel, Kristina, Shirima, Gabriel, Shyaka, Anselme, Wood, Catherine, Yussuf, Buke, and Caron, Alexandre

Published
2024
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18. Transplanting old organs promotes senescence in young recipients

Author

Iske, Jasper, Roesel, Maximilian J., Martin, Friederike, Schroeter, Andreas, Matsunaga, Tomohisa, Maenosono, Ryoichi, Tripathi, Utkarsh, Xiao, Yao, Nian, Yeqi, Caldarone, Barbara J., Vondran, Florian W.R., Sage, Peter T., Azuma, Haruhito, Abdi, Reza, Elkhal, Abdallah, Pirtskhalava, Tamar, Tchkonia, Tamara, Kirkland, James L., Zhou, Hao, and Tullius, Stefan G.

Published
2024
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34. The Role of Floods on Pathogen Dispersion

Author

Bett, Bernard, Tumusiime, Dan, Lindahl, Johanna, Roesel, Kristina, Delia, Grace, Barceló, Damià, Series Editor, de Boer, Jacob, Editorial Board Member, Kostianoy, Andrey G., Series Editor, Garrigues, Philippe, Editorial Board Member, Hutzinger, Otto, Founding Editor, Gu, Ji-Dong, Editorial Board Member, Jones, Kevin C., Editorial Board Member, Knepper, Thomas P., Editorial Board Member, Negm, Abdelazim M., Editorial Board Member, Newton, Alice, Editorial Board Member, Nghiem, Duc Long, Editorial Board Member, Garcia-Segura, Sergi, Editorial Board Member, Ferreira, Carla S. S., editor, Kalantari, Zahra, editor, Hartmann, Thomas, editor, and Pereira, Paulo, editor

Published
2022
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35. Interdisciplinary Methods and New Perspectives on Inscribed Textiles: A Case Study of Christian ‘Tiraz’

Author

Galliker, Julia, Rösel-Mautendorfer, Helga, Eerkens, Jelmer, Series Editor, Çak?rlar, Canan, Editorial Board Member, Iizuka, Fumie, Editorial Board Member, Seetah, Krish, Editorial Board Member, Sugranes, Nuria, Editorial Board Member, Tushingham, Shannon, Editorial Board Member, Wilson, Chris, Editorial Board Member, Ulanowska, Agata, editor, Grömer, Karina, editor, Vanden Berghe, Ina, editor, and Öhrman, Magdalena, editor

Published
2022
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41. Versicherungen

Author

Rösel, Wolfgang, Busch, Antonius, Rode, Bernd, Rösel, Wolfgang, Busch, Antonius, and Rode, Bernd

Published
2020
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