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29. Fatal Aspergillus myocarditis following short-term corticosteroid therapy for chronic obstructive pulmonary disease

Author

Corral Mones J, Zabaleta Murguiondo M, Carrascosa Porras M, Herreras Martínez R, Ares Ares M, and Rüchel R

Subjects
Microbiology (medical), Male, medicine.medical_specialty, Myocarditis, Heart disease, Exacerbation, Anti-Inflammatory Agents, Aspergillosis, Methylprednisolone, Pulmonary Disease, Chronic Obstructive, Fatal Outcome, Internal medicine, medicine, Humans, Mycosis, COPD, General Immunology and Microbiology, business.industry, Respiratory disease, General Medicine, Middle Aged, medicine.disease, Surgery, Infectious Diseases, Aspergillus, Mycoses, business, medicine.drug
Abstract

A 58-y-old man with chronic obstructive pulmonary disease (COPD) was admitted for treatment of an acute exacerbation of his illness. The patient's condition initially improved after therapy with oxygen, bronchodilators, antibiotic and methylprednisolone (40 mg every 8 h) was started. Soon afterwards, however, the patient's clinical status deteriorated and he died on the fifth hospital day. Post-mortem examination revealed unsuspected, isolated fungal myocarditis. The fungus was later identified as Aspergillus by indirect immunofluorescence. To our knowledge, this is the first case of fatal Aspergillus myocarditis related to short-term (< 1 week) steroid therapy in a COPD patient. We believe that this case provides further evidence to support the possibility of life-threatening infections in COPD patients who receive even a short course of corticosteroid treatment.

Published
2002

38. Sequence of the Candida albicans gene encoding the secretory aspartate proteinase

Author

Bernhard Hube, Cj, Turver, Fc, Odds, Eiffert H, Gj, Boulnois, Köchel H, and Rüchel R

Subjects
Open Reading Frames, Base Sequence, Candida albicans, Molecular Sequence Data, Aspartic Acid Endopeptidases, Amino Acid Sequence, Cloning, Molecular, Protein Sorting Signals, DNA, Fungal, Oligonucleotide Probes, Polymerase Chain Reaction, Culture Media
Abstract

The gene encoding the Candida albicans aspartate proteinase that is secreted by cells grown in protein-containing media was cloned from a C. albicans genomic bank. The base sequence of the insert shows a 1173 bp open-reading frame and indicates an amino acid sequence typical of aspartate proteinases, with amino acid sequence homology to other enzymes of this class and a putative signal peptide consisting of 50 amino acids upstream of the active enzyme.

Published
1991

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