373 results on '"R., Vikram"'
Search Results
2. The Cascade of Care in Management of Solid Organ Transplant Candidates With Latent Tuberculosis Infection
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Chia-Yu Chiu, MD, Maryam Mahmood, MD, Lisa M. Brumble, MD, Holenarasipur R. Vikram, MD, Elitza S. Theel, PhD, and Elena Beam, MD
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Surgery ,RD1-811 - Abstract
Background. Solid organ transplant (SOT) candidates should be screened and treated for latent tuberculosis infection (LTBI) to prevent tuberculosis (TB) reactivation after transplantation. We aimed to assess the steps from positive QuantiFERON (QFT) through LTBI treatment (cascade of care) in the SOT population. Methods. We conducted a retrospective study of SOT recipients older than 18 y with a positive QFT during pretransplant evaluation at the Mayo Clinic from January 2010 to June 2023. We analyzed each cascade step to determine associated drop-out factors for LTBI management. Results. Of 629 patients who had positive QFT results, 587 (93%) were evaluated by an infectious disease (ID) specialist, 478 (76%) were recommended to start LTBI treatment, 473 (75%) initiated LTBI treatment, and 457 (73%) completed LTBI treatment. LTBI treatment was not recommended in 109 patients evaluated by infectious disease, most of whom had previously received either LTBI (n = 72) or TB (n = 14) treatment. LTBI treatment was initiated before or after transplantation for 45% and 55% of patients, respectively. Isoniazid monotherapy was the most common regimen (92%), and adverse events were rare (7%). Seven patients developed active TB infection posttransplantation under various circumstances (3 without LTBI treatment, 1 during LTBI treatment, and 3 after completing LTBI treatment). Conclusions. Our findings demonstrate the variability of LTBI management in SOT recipients with positive QFT. When recommended, most patients completed LTBI treatment successfully. Nonetheless, active TB was noted regardless of whether patients received LTBI treatment. This study highlights the importance of optimizing LTBI management in this population.
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- 2024
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3. Invasive Nocardia Infections across Distinct Geographic Regions, United States
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Simran Gupta, Leah M. Grant, Harry R. Powers, Kathryn E. Kimes, Ahmed Hamdi, Richard J. Butterfield, Juan Gea-Banacloche, Prakhar Vijayvargiya, D. Jane Hata, Diana M. Meza Villegas, Adrian C. Dumitrascu, Dana M. Harris, Razvan M. Chirila, Nan Zhang, Raymund R. Razonable, Shimon Kusne, Salvador Alvarez, and Holenarasipur R. Vikram
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Nocardia ,nocardiosis ,bacteria ,transplant ,transplantation-associated infections ,environmental pathogens ,Medicine ,Infectious and parasitic diseases ,RC109-216 - Abstract
We reviewed invasive Nocardia infections in 3 noncontiguous geographic areas in the United States during 2011–2018. Among 268 patients with invasive nocardiosis, 48.2% were from Minnesota, 32.4% from Arizona, and 19.4% from Florida. Predominant species were N. nova complex in Minnesota (33.4%), N. cyriacigeorgica in Arizona (41.4%), and N. brasiliensis in Florida (17.3%). Transplant recipients accounted for 82/268 (30.6%) patients overall: 14 (10.9%) in Minnesota, 35 (40.2%) in Arizona, and 33 (63.5%) in Florida. Manifestations included isolated pulmonary nocardiosis among 73.2% of transplant and 84.4% of non–transplant patients and central nervous system involvement among 12.2% of transplant and 3.2% of non–transplant patients. N. farcinica (20.7%) and N. cyriacigeorgica (19.5%) were the most common isolates among transplant recipients and N. cyriacigeorgica (38.0%), N. nova complex (23.7%), and N. farcinica (16.1%) among non–transplant patients. Overall antimicrobial susceptibilities were similar across the 3 study sites.
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- 2023
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4. Cytomegalovirus infection in heart transplant recipients: Epidemiology, risk factors, and long-term outcomes from a major transplant center in the United States
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Bismarck S. Bisono-Garcia, MD, Zachary A. Yetmar, Vaisak Nair, Lisa Brumble, Holenarasipur R. Vikram, Raymund R. Razonable, and Elena Beam
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cytomegalovirus ,heart transplantation ,opportunistic infection ,antiviral ,Surgery ,RD1-811 ,Specialties of internal medicine ,RC581-951 - Abstract
Background: Despite the use of antiviral prophylaxis, cytomegalovirus (CMV) remains a common opportunistic infection following heart transplantation. This study analyzes the rates, risk factors, and outcomes of CMV among heart transplant recipients. Methods: A retrospective cohort study was conducted of adults who underwent heart transplantation between January 1, 2011, and March 31, 2019. The primary outcome was clinically significant CMV infection (csCMVi), defined as CMV disease or asymptomatic infection requiring pre-emptive therapy. The secondary outcome was all-cause mortality. Patients received valganciclovir prophylaxis up to 6 months, depending on CMV donor/recipient serostatus. Kaplan-Meier curve and multivariable Cox regression were used for outcome analysis. Results: Among 553 heart transplant recipients, 101 (18.3%) experienced csCMVi, including 35 (6.3%) with CMV disease. csCMVi was uncommon during prophylaxis. In multivariable analysis, CMV D+/R– status hazard ratio (HR 12.88, 95% CI 6.76-24.56; p
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- 2024
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5. Impact of Early Rejection Treatment on Infection Development in Kidney Transplant Recipients: A Propensity Analysis
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Simran Gupta, Juan Gea-Banacloche, Raymond L. Heilman, Reena N. Yaman, Hay Me Me, Nan Zhang, Holenarasipur R. Vikram, and Lavanya Kodali
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Surgery ,RD1-811 - Abstract
Introduction. The impact of renal allograft rejection treatment on infection development has not been formally defined in the literature. Methods. We conducted a retrospective cohort study of 185 rejection (case) and 185 nonrejection (control) kidney transplant patients treated at our institution from 2014 to 2020 to understand the impact of rejection on infection development. Propensity scoring was used to match cohorts. We collected data for infections within 6 months of rejection for the cases and 18 months posttransplant for controls. Results. In 370 patients, we identified 466 infections, 297 in the controls, and 169 in the cases. Urinary tract infections (38.9%) and cytomegalovirus viremia (13.7%) were most common. Cumulative incidence of infection between the case and controls was 2.17 (CI 1.54–3.05); p
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- 2024
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6. Material and Component Selection for Efficient Energy Harvesting
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Gelli, N V R Vikram, Chlamtac, Imrich, Series Editor, Nella, Anveshkumar, editor, Bhowmick, Anirban, editor, Kumar, Chandan, editor, and Rajagopal, Maheswar, editor
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- 2023
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7. Effect of Low Volume Reinforcement of Graphene/B4C Nano Particles in Aluminium 6061-T6 Alloy
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Ammisetty, Saikiran, Kumar, CH. R. Vikram, Reddy, K. Hemachandra, Chaari, Fakher, Series Editor, Gherardini, Francesco, Series Editor, Ivanov, Vitalii, Series Editor, Cavas-Martínez, Francisco, Editorial Board Member, di Mare, Francesca, Editorial Board Member, Haddar, Mohamed, Editorial Board Member, Kwon, Young W., Editorial Board Member, Trojanowska, Justyna, Editorial Board Member, Bhattacharyya, Bijoy, editor, Mathew, Jose, editor, Saravanakumar, N., editor, and Rajeshkumar, G., editor
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- 2023
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8. Species designation of streptococci causing infective endocarditis in patients with mitral valve prolapse
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Juan A. Quintero-Martinez, Joya-Rita Hindy, Said El Zein, Holenarasipur R. Vikram, Wendelyn Bosch, Daniel C. DeSimone, and Larry M. Baddour
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Infective endocarditis ,Mitral valve prolapse ,Streptococci ,Viridans group streptococci ,Streptococcus mitis ,Infectious and parasitic diseases ,RC109-216 - Abstract
ABSTRACT: Objectives: Viridans group streptococci (VGS) have been previously linked to infective endocarditis (IE) in patients with mitral valve prolapse (MVP). The species identification of VGS is now available in clinical laboratories; however, it has not been examined in MVP IE. Therefore, we detailed the clinical profile, species designations, and antibiotic susceptibility of VGS isolates from patients with MVP IE. Methods: We retrospectively queried all adults with MVP and a definite or possible IE diagnosis seen at medical centers of the Mayo Clinic Enterprise from January 2009 to December 2021. Data, including clinical characteristics, comorbidities, microbiology, and outcomes, were extracted from electronic health records. VGS isolates from patients with MVP and IE were subclassified into mutans, salivarius, anginosus, sanguinis, and mitis groups. Results: A total of 38 patients with MVP with IE due to streptococcal species were included. Overall, median age was 62.4 years and 32% of patients were females. The most prevalent comorbidities were diabetes mellitus (26%), hypertension (21%), heart failure (16%), and malignancy (16%). A total of (37%) patients presented with an embolic event at the time of their IE diagnosis, 27 (66%) required valve surgery, and no patient died within the hospital stay. The Streptococcus mitis group was the predominant (n = 17, 45%) species designation; S. anginosus and S. sanguinis were identified in three (8%) each; S. mutans in two (5%); and S. salivarius in one (3%). Non-VGS streptococcal pathogens included S. agalactiae in three patients (8%), S. equi in two (5%), and S. dysgalactiae and S. bovis in one each (3%). VGS were identified in five (13%) patients, but species designation was not done. No penicillin resistance was identified among the isolates. Conclusion: The S. mitis group was the predominant species in our investigation. Continued evaluation of VGS species should be considered to profile the IE risk based on species identification.
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- 2023
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9. Development of a novel activation function based on Chebyshev polynomials: an aid for classification and denoising of images.
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M. Deepthi, G. N. V. R. Vikram, and P. Venkatappareddy
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- 2023
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10. Double-lumen endotracheal tube in pediatric intensive care unit: A lifesaver in a leukemic child with pulmonary hemorrhage: A case report
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Parvathy S Menon, Indira Jayakumar, R Vikram Rajkumar, Venkateswaran Vellaichamy Swaminathan, and C Vasantha Roopan
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angioinvasive aspergillosis ,double-lumen endotracheal tube ,pulmonary hemorrhage ,Pediatrics ,RJ1-570 - Abstract
We describe a case of life-threatening pulmonary hemorrhage in a boy with leukemia. He had episodes of massive hemoptysis for which he was intubated and resuscitated with multiple blood products, hemostatic measures (tranexamic acid and recombinant factor VIIa), and inotropes. Chest X-ray revealed left upper lobe homogeneous opacity. Within 12 h, in view of persistent massive pulmonary bleed and hypoxia, he was reintubated with a left-sided double-lumen endotracheal tube (DLT). Following reintubation with DLT, pulmonary bleed could be managed. He was treated for probable left upper lobe angioinvasive aspergillosis. He was weaned off ventilatory support and extubated after 48 h to high flow nasal canula (HFNC). This case is to highlight the importance of early use of DLTs in pulmonary hemorrhage due to suspected unilateral lung pathologies to facilitate isolation of diseased lung, improve ventilation, and prevent spillage of blood to the contralateral normal lung. It serves as a temporizing measure, while aggressive efforts to identify and control the bleed are underway.
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- 2023
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11. Seasonal stress on semen quality profiles, seminal biochemical and oxidative stress attributes in endangered Teressa goat of Andaman and Nicobar Islands
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P Perumal, Jai Sunder, A K De, D Bhattacharya, A K Nahak, R Vikram, and E B Chakurkar
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andaman and nicobar islands ,teressa goat ,semen quality profiles ,season ,liquid storage ,Medicine - Abstract
Objective: To measure seasonal effects on semen quality profiles, seminal biochemical and oxidative stress attributes in fresh and liquid stored semen in monsoon and dry seasons. Methods: A total of 10 Teressa bucks (3-4 years) were selected from breeding farm, ICAR-Central Island Agricultural Research Institute, Port Blair, Andaman and Nicobar Islands, India. Semen samples (n=25 per season) were collected through artificial vagina method and preserved at refrigerated temperature (5°C) for 48 h using Tris citrate glucose based extender. We detected semen quality parameters [volume, mass activity, pH, sperm concentration, total motility, viability, total sperm abnormality, and plasma membrane, acrosomal and nuclear integrities], biochemical profiles [aspartate amino transferase (AST), alanine amino transferase (ALT) and total cholesterol], and oxidative stress markers [total antioxidant capacity (TAC) and malondialdehyde (MDA)] during monsoon and dry seasons. Results: Semen quality parameters significantly differed between seasons (P
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- 2023
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12. Material and Component Selection for Efficient Energy Harvesting
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Gelli, N V R Vikram, primary
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- 2023
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13. A Machine Learning Approach for Daily Temperature Prediction Using Big Data
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Divakarla, Usha, Chandrasekaran, K., Reddy, K. Hemanth Kumar, Reddy, R. Vikram, Gururaj, Manjula, Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, Suma, V., editor, Baig, Zubair, editor, Kolandapalayam Shanmugam, Selvanayaki, editor, and Lorenz, Pascal, editor
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- 2022
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14. Effect of Low Volume Reinforcement of Graphene/B4C Nano Particles in Aluminium 6061-T6 Alloy
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Ammisetty, Saikiran, primary, Kumar, CH. R. Vikram, additional, and Reddy, K. Hemachandra, additional
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- 2022
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15. Inclusion of catalase in semen extender modulates the post thaw semen quality and oxidative stress profiles in mithun spermatozoa
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P PERUMAL, A K DE, R VIKRAM, and M H KHAN
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Antioxidants, Catalase, Cryopreservation, Kinematic profiles, Mithun, Oxidative stress, Spermatozoa ,Animal culture ,SF1-1100 - Abstract
Present study was designed to assess the effect of catalase on post-thaw semen quality parameters (SQPs), sperm kinematics, antioxidant and oxidative stress profiles and sperm cholesterol efflux in mithun (Bos frontalis). A total of 25 ejaculates were selected based on biophysical parameters and each sample was split into four equal aliquots and diluted (to get final concentration of 60 million spermatozoa per mL) with the TCG extender containing either 0 U/mL, 50 U/mL, 100 U/mL, and 150 U/mL catalase in the Group I, II, III and IV, respectively. Frozen-thawed samples were analysed for motility parameters (progressive forward and in bovine cervical mucus [BCMPT]), kinetic and velocity parameters by computer-assisted sperm analyser (CASA), viability, sperm morphological and nuclear abnormalities, acrosomal integrity, plasma membrane and nuclear integrities, sperm intra-cellular enzymatic leakage and seminal plasma biochemical (sperm cholesterol and oxidative stress markers) profiles. Study revealed an enhancement in viability, acrosomal integrity, plasma membrane integrity, motility (progressive and in cervical mucus), sperm cholesterol content and reduction in sperm morphological and nuclear abnormalities, leakage of intracellular enzymes in Group III. Moreover, intactness of acrosome and biochemical membranes were protected significantly in addition to significant improvement in kinetic and velocity profiles in extender containing 100 U/ml catalase. Correlation analysis revealed that sperm kinetic parameters, SQPs and antioxidant parameters had significant positive correlation with each other whereas these profiles were negatively correlated with sperm morphological abnormalities, enzymatic leakage and lipid peroxidation in catalase treated sperm. The results clearly indicated that inclusion of 100 U/ml catalase holds a clear advantage over control or 50 U/ml or 150 U/ml catalase in cryopreservation of mithun semen. It can be concluded from the present study that catalase supplementation in semen extender can be effectively utilized to reduce the oxidative stress and to improve the post-thaw semen quality in mithun.
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- 2022
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16. Case report: Emphysematous pyelonephritis associated with kidney allograft abscess formation
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Bassam G. Abu Jawdeh, Michelle C. Nguyen, Margaret S. Ryan, and Holenarasipur R. Vikram
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immunosuppression ,kidney ,emphysematous pyelonephritis ,kidney transplant recipient ,graft nephrectomy ,Medicine (General) ,R5-920 - Abstract
Emphysematous pyelonephritis (EPN) is a severe, acute necrotizing infection that is defined by the presence of gas in the kidney parenchyma. Multiple case reports have described the radiological findings and clinical course of EPN. Herein, we report on EPN including the histopathological findings in a kidney transplant recipient. Our patient presented with EPN complicated by multiorgan failure and was successfully managed with transplant nephrectomy.
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- 2022
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17. A Machine Learning Approach for Daily Temperature Prediction Using Big Data
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Divakarla, Usha, primary, Chandrasekaran, K., additional, Reddy, K. Hemanth Kumar, additional, Reddy, R. Vikram, additional, and Gururaj, Manjula, additional
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- 2022
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18. Exploring Different Approaches for Parsing Telugu
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Venkata Seshu Kumari, B., Giri Prasaad, A., Susmitha, M., R., Vikram Raju, Bhatnagar, Roheet, Kacprzyk, Janusz, Series Editor, Pal, Nikhil R., Advisory Editor, Bello Perez, Rafael, Advisory Editor, Corchado, Emilio S., Advisory Editor, Hagras, Hani, Advisory Editor, Kóczy, László T., Advisory Editor, Kreinovich, Vladik, Advisory Editor, Lin, Chin-Teng, Advisory Editor, Lu, Jie, Advisory Editor, Melin, Patricia, Advisory Editor, Nedjah, Nadia, Advisory Editor, Nguyen, Ngoc Thanh, Advisory Editor, Wang, Jun, Advisory Editor, Hassanien, Aboul Ella, editor, Azar, Ahmad Taher, editor, Gaber, Tarek, editor, Bhatnagar, Roheet, editor, and F. Tolba, Mohamed, editor
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- 2020
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19. Effect of Superoxide dismutase on cryopreservation of mithun semen
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Perumal Ponraj, A K DE, R VIKRAM, K KHATE, K VUPRU, M H KHAN, A K NAHAK, and P C MISHRA
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Cryopreservation ,Kinetic profiles ,Mithun ,Semen ,Superoxide dismutase ,Animal culture ,SF1-1100 - Abstract
The present study was designed to assess the effect of superoxide dismutase (SOD) on post thaw semen quality parameters (SQPs), kinetic profiles and seminal biochemical profiles in mithun. A total of 25 ejaculates were selected and each was split into four equal aliquots after dilution with Tris-citrate-glycerol (TCG) extender such as Group I: control, Group II, III and IV contained 50, 100 and 150 U/ml of SOD, respectively. Cryopreserved and thawed samples were analysed for their motility parameters (progressive forward and in bovine cervical mucus penetration test [BCMPT]), kinetic and velocity parameters by computer assisted sperm analyser (CASA), viability, sperm morphological and nuclear abnormalities, acrosomal, plasma membrane and nuclear integrities and sperm enzymatic leakage and biochemical (sperm cholesterol and antioxidant and oxidative stress) profiles. Study revealed a significant (p
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- 2022
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20. A comparative assessment of apical debris extrusion by various glide path establishing endodontic instruments: An in vitro study
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V P Anshida, M E Sudhanva, R Vikram, and Vishwas S Gowda
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debris extrusion ,glide-path ,nickel-titanium ,proglider ,waveone gold glider ,Dentistry ,RK1-715 - Abstract
Introduction: A reproducible glide path provides guidance to fulfil the mechanical objective of cleaning and shaping root canals with minimal procedural errors. Debris expelled during this procedure contributes to inter-appointment flare-up. The objective of this in vitro study was to estimate and compare the quantity of debris extruded by; hand, rotary and reciprocating glide path preparation instruments. Materials and Methods: Seventy-five human single rooted, matured mandibular incisors with single canal and comparable lengths were randomly allocated into three groups (n = 25): group A – Stainless steel (SS) K-file (No 15), Group B – ProGlider, and Group C –WaveOne Gold Glider. Customized apparatus using Meyers and Montgomery method was utilized to accumulate the debris expelled apically in the Eppendorf tubes weighed priorly in digital analytical balance of 10−6 g accuracy. All groups were instrumented as per the manufacturer's guidelines. After instrumentation, teeth were detached from the Eppendorf tubes and tubes incubated at 70°C for 5 days to vaporize the irrigating solution. The tubes with dry debris were later weighed in the same weighing balance. The collected information was analyzed by one-way ANOVA and Tukeys honest significant difference post hoc test at significance level (P < 0.05). Results: The ProGlider group expressed statistically significant result with least quantity of extruded debris in the comparison to other groups (P < 0.0001). The SS group and WaveOne Gold Glider group exhibited no significant difference, but the debris expelled was less for WaveOne Gold Glider group than SS group. Conclusion: Glide path preparations with rotary ProGlider resulted in the minimal extrusion of debris in comparison to the reciprocating WaveOne Gold Glider and the manual stainless-steel K-files.
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- 2021
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21. Daily and seasonal rhythmic secretary pattern of antioxidant and oxidative stress biomarkers in mithun bull
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P PERUMAL, R VIKRAM, M N SADDAM HUSEN, and M H KHAN
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24-h profiles ,Antioxidant ,Mithun ,Oxidant ,Seasonality ,Animal culture ,SF1-1100 - Abstract
A study was conducted to assess the rhythmic changes of antioxidant and oxidative stress profiles (antioxidantand oxidative stressors together is called as oxidative stress biomarkers: OSBs) to understand their flow pattern in24 h during different seasons (winter, spring, summer and autumn) in intact adult mithun bulls (n=6; 5–6 years).Antioxidants [total antioxidant capacity (TAC), superoxide dismutase (SOD), glutathione (GSH), glutathionereductase (GSHR) and catalase (CAT)] and oxidative stressor [malondialdehyde (MDA)] were estimated at 4 hinterval for a whole day in different seasons. Analysis was done in two different ways with respect to time (0800,1200, 1600, 2000, 2400 and 0400 h) and day time (0800 to 1600 h) and night time (2000 to 0400 h) collections. Thelevels of OSBs differed significantly among the seasons, among the collection times and between day and nighttimes. Winter and spring had recorded significantly higher antioxidants and lower MDA than summer. Levels ofantioxidants were higher and MDA was lower during night as compared to day time collections. It was concludedthat spring and winter seasons had greater beneficial effects than summer on health and wellbeing of the mithun.
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- 2022
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22. Solid Organ Transplantation From SARS-CoV-2–infected Donors to Uninfected Recipients: A Single-center Experience
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Channa R. Jayasekera, MD, Holenarasipur R. Vikram, MD, Zeeshan Rifat, MBBS, Josiah Wagler, DO, Keita Okubo, MD, PhD, Brandon R. Braaksma, PA-C, Jack W. Harbell, MD, Caroline C. Jadlowiec, MD, Nitin N. Katariya, MD, Amit K. Mathur, MD, Adyr Moss, MD, K. Sudhakar Reddy, MBBS, Andrew Singer, MD, PhD, Robert Orenstein, DO, Christopher F. Saling, MD, Maria T. Seville, MD, Girish K. Mour, MD, Hugo E. Vargas, MD, Thomas J. Byrne, MD, Winston R. Hewitt, Jr, MD, and Bashar A. Aqel, MD
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Surgery ,RD1-811 - Abstract
Background. The risk of donor-derived severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in solid organ (heart, lung, liver, kidney, pancreas, and intestine) transplant recipients is poorly understood. Since hematogenous transmission of SARS-CoV-2 has not been documented to date, nonlung solid organs might be suitable for transplantation since they likely portend a low risk of viral transmission. Methods. Abdominal solid organs from SARS-CoV-2–infected donors were transplanted into uninfected recipients. Results. Between April 18, 2021, and October 30, 2021, we performed transplants of 2 livers, 1 simultaneous liver and kidney, 1 kidney, and 1 simultaneous kidney and pancreas from SARS-CoV-2–infected donors into 5 uninfected recipients. None of the recipients developed SARS-CoV-2 infection or coronavirus disease 2019, and when tested, allograft biopsies showed no evidence of SARS-CoV-2 RNA. Conclusions. Transplanting nonlung organs from SARS-CoV-2–infected donors into uninfected recipients demonstrated no evidence of virus transmission.
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- 2022
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23. Glutathione in semen extender modulates post thaw semen quality profiles, and antioxidant and oxidative stress profiles in mithun
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P PERUMAL, R VIKRAM, K KHATE, K VUPRU, M N SADDAMHUSEN, and M H KHAN
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Antioxidants ,Cryopreservation ,Glutathione ,Kinetic profiles ,Mithun ,Oxidative stress ,Animal culture ,SF1-1100 - Abstract
Present study was designed to assess the effect of glutathione (GSH) on post thaw semen quality parameters (SQPs), sperm kinetic profiles, antioxidant and oxidative stress profiles and sperm cholesterol efflux in mithun. Ejaculates (25) were selected based on biophysical parameters for the present experiment. Each sample was split into four equal aliquots after dilution with the Tris-citrate-glycerol (TCG) extender, viz. Group I (control), Group II, III and IV contained 5, 10 and 15 mM of GSH, respectively. Cryopreserved and thawed samples were analysed for their motility parameters (progressive forward and in bovine cervical mucus penetration test [BCMPT]), kinetic and velocity parameters by computer assisted sperm analyser (CASA), viability, sperm and nuclear abnormalities, acrosomal integrity, plasma membrane and nuclear integrities, sperm enzymatic leakage and biochemical (sperm cholesterol and antioxidant and oxidative stress) profiles. Study revealed a significant enhancement in viability, sperm and nuclear normalities, acrosomal integrity, motility (progressive and in cervical mucus), sperm cholesterol content and reduction in leakage of intracellular enzymes in Group III. Moreover, intactness of acrosome and biochemical membranes were protected significantly in addition to significant improvement in kinetic and velocity profiles in extender containing 10 mM GSH. These results clearly indicate that though the cryopreservation of mithun’s spermatozoa in TCG was comparable with other species, inclusion of 10 mM GSH holds a clear advantage over control and 5 or 15 mM GSH. The study concludes that GSH supplementation in semen extender can be effectively utilized to reduce the oxidative stress and improve the antioxidant profiles with cascading beneficial effects on cryopreserved semen quality parameters in mithun bull.
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- 2022
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24. Post Training Mixed Precision Quantization of Neural Networks using First-Order Information
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Chauhan, Arun, primary, Tiwari, Utsav, additional, and R, Vikram N, additional
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- 2023
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25. Comparative evaluation of smear layer removal efficacy of three herbal irrigants in the apical third of the root canal: An in vitro scanning electron microscopic study
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G R Ranjitha, Shreya Rajesh Mutha, R Anithakumari, R Vikram, Naveen Kumar, and A K Shivekshith
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herbal irrigants ,neem ,orange peel extract ,root canal irrigants ,smear layer ,tulasi ,Dentistry ,RK1-715 - Abstract
Background: Smear layer removal from the apical third of the root canal is critical and the widely used chemical irrigants have been associated with detrimental effects. Hence, the study aimed to evaluate the smear layer removal efficacy of three herbal extracts used as endodontic irrigants in the apical third of the root canal. Materials and Methods: Forty-eight single-rooted premolars were divided into three experimental groups and a control group and were irrigated with Neem extract (Group 1), Orange peel extract (Group 2), Tulasi extract (Group 3), 5.25% sodium hypochlorite (Group 4) and their effect on smear layer removal was examined under the field-emission scanning electron microscope. Statistical Analysis: Kruskal–Wallis test followed by Mann–Whitney post-hoc analysis was done to compare the mean smear layer scores between the four groups in the apical third of the root sections. Results: The lowest mean remaining smear layer scores was shown by Neem extract (0.83), followed by sodium hypochlorite (1.08), orange peel extract (1.67), and the highest for Tulasi extract (2.42). On intergroup comparison, Neem extract showed statistically significant less smear layer scores in comparison to Orange peel extract (P = 0.006) and Tulasi (P = 0.001). Neem showed no statistically significant difference with sodium hypochlorite (P = 0.37). Conclusions: Neem extract can be considered as an efficient smear layer removal irrigant in the apical third of the root canal.
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- 2020
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26. Melatonin modulates daily and seasonal rhythmic secretary pattern of endocrinological profiles in mithun bull
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P PERUMAL, A K DE, R VIKRAM, M H KHAN, A K NAHAK, and P C MISHRA
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Melatonin ,24-h profiles ,seasonality ,endocrinological profiles ,mithun ,Animal culture ,SF1-1100 - Abstract
Present study was designed to evaluate the effect of slow release exogenous melatonin on endocrinological profiles in 24:00 hours in adult mithun bulls during different seasons (winter, spring, summer and autumn). Mithun bulls (n=12) were selected and divided into two groups, Gr I: Control (n=6) and Gr II: Treatment (n=6; melatonin implant @ 18 mg/50 kg bwt). Endocrinological profiles such as follicle stimulating hormone (FSH), luteinizing hormone (LH), testosterone, cortisol, thyroxine (T4), insulin like growth factor-1 (IGF-1), prolactin and melatonin (MT) were estimated at 04:00 h interval (08:00, 12:00, 16:00, 20:00, 24:00 and 04:00 h) for one whole day in four seasons. Melatonin treated group had significantly higher FSH, LH, testosterone, IGF-1 and MT than control group; and MT significantly reduced the level of T4, cortisol and prolactin in different seasons at different collection times. The study concludes that MT has significantly improved the endocrine profiles in different seasons and collection times. MT treatment and spring and winter season had significantly greater beneficial effects on reproduction and artificial breeding programs in mithun species in the semi-intensive management in the present location.
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- 2021
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27. Assisted reproductive technologies ( <scp>ARTs</scp> ) in Mithun ( Bos frontalis ): What progress has been made so far? An overview
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R. Vikram, P. Perumal, M. H. Khan, and P. S. Girish
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Endocrinology ,Animal Science and Zoology ,Biotechnology - Published
- 2023
28. A study to assess the effectiveness of selected recreational activity on stress among elderly people in selected old age home at Chennai
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B, Tamilarasi, primary, P, Jessy Rani, additional, S, Arthi, additional, M, Indumathi, additional, S, Manibharathi, additional, R, Reegan, additional, and R, Vikram, additional
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- 2023
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29. Studies on particle separation equipment – A review.
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Venkatesh, S., Kathirvel, M., Dharsan, R. Vikram, Yogaraju, K., and Balasubramani, S.
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AIR pollution ,INDUSTRIALISM ,FLUID dynamics ,EXHAUST systems ,DUST - Abstract
Numerous industries contribute to air pollution by releasing smoke and dust into the environment. Devices called settling chambers are used in industrial exhaust systems to filter out solid particles. As they move through the chamber, gravity's pull causes particles to fall to settling trays, cleaning the gas. The particular area unit is quite reliable at collection comparatively little particles. Such structures should be operationally effective, constructional safe and is implemented and efficient. This style of those equipment is confined to their hydro dynamic, which is simply centred within the particle on the particle following settling concept, and borderline focus dedicated to construction security and value reduction. The method for designing a settling chamber that meets the requirements for fluid dynamics, structural safety, and cost minimization. [ABSTRACT FROM AUTHOR]
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- 2023
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30. Self-Diffusion by Multivariate-Normal Turbulent Velocity Field
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Pandya, R. Vikram Raj
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Condensed Matter - Statistical Mechanics - Abstract
A closed set of \textit{exact} equations describing statistical theory of turbulent self-diffusion by multivariate-normal turbulent velocity field is derived. In doing so, we first suggest exact formulas for correlations $
$, $ $ and $ $ when the functional $R[{\bf f}]$ is functional of functions ${f_i}$'s having multivariate-normal distribution, $g$ and $f_i$'s have joint normal distribution and zero mean values., Comment: 8 pages - Published
- 2005
31. Exploring Different Approaches for Parsing Telugu
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Venkata Seshu Kumari, B., primary, Giri Prasaad, A., additional, Susmitha, M., additional, R., Vikram Raju, additional, and Bhatnagar, Roheet, additional
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- 2019
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32. Risk factors and outcomes of Pneumocystis pneumonia in solid organ transplant recipients: Impact of posttransplant lymphoproliferative disorder
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Zachary A. Yetmar, Dustin Duffy, Byron H. Smith, Holenarasipur R. Vikram, Lisa Brumble, Andrew H. Limper, and Elena Beam
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Transplantation - Published
- 2023
33. Crime Hotspot Identification using SVM in Machine Learning
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K Vinothkumar, Kumar S Ranjith, Raj R Vikram, N. Mekala, R. Reshma, and S.P. Sasirekha
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- 2023
34. Secure Multipoint Relay Node Selection in Mobile Ad Hoc Networks.
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Jeril Kuriakose, V. Amruth, and R. Vikram Raju
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- 2015
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35. Energy-Efficient Clustering and Routing Algorithm Using Hybrid Fuzzy with Grey Wolf Optimization in Wireless Sensor Networks
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Jainendra Singh, J. Deepika, null Zaheeruddin, J. Sathyendra Bhat, V. Kumararaja, R. Vikram, J. Jegathesh Amalraj, V. Saravanan, and S. Sakthivel
- Subjects
Article Subject ,Computer Networks and Communications ,Information Systems - Abstract
Wireless networking is popular due to the “3 any” concept: anyone, anytime, anywhere. Wireless communication technology advancements have covered the opportunities for sustainable development of low-power, low-cost, multipurpose sensor nodes in wireless sensor networks. In sensor networks, the network layer handles routing problems. Since radio transmission requires a significant amount of energy, it is essential to investigate power efficiency and optimization. As a result, the conservation of energy is a critical concern in wireless sensor networks. Recent research is focused on developing routing algorithms that use less amount of energy during communication, thereby prolonging the network’s life. Wireless sensor networks with energy recovery nodes use nodes that can extract energy from their environment. The fuzzy-GWO method and the energy-saving routing algorithm are proposed and analyzed in this research work. For simulation, the MATLAB 2021b working environment is used. The LEACH, HEED, MBC, FRLDG protocols, along with the proposed protocol F-GWO, are compared. From the obtained results, it is found that the network lifetime is increased by 20%, 14.8%, 12.5%, and 3.8%, respectively. In addition, the proposed method has a 37.5%, 33.3%, 16.6%, and 6.25% reduction in average energy consumption when compared with the conventional algorithms. According to the experimental data obtained through simulation, the proposed F-GWO algorithm outperforms the LEACH, HEED, MBC, and FRLDG in network lifetime, packet delivery ratio, throughput, bit error rate (BER), buffer occupancy, time analysis, and end-to-end delay.
- Published
- 2022
36. Sign Language Translator for Speech Impaired
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K, Dr Ananthajothi., primary, R, Srisai, additional, R, Vikram, additional, and S, Srivathsan, additional
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- 2023
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37. Progressive Back Pain due to Aspergillus nidulans Vertebral Osteomyelitis in an Immunocompetent Patient: Surgical and Antifungal Management
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Mark K. Lyons, Matthew T. Neal, Naresh P. Patel, and Holenarasipur R. Vikram
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Orthopedic surgery ,RD701-811 - Abstract
Case Report. Aspergillus osteomyelitis is a destructive and progressive infection that has been described both in immunosuppressed and in immunocompetent hosts. We describe a case of lumbar vertebral osteomyelitis in a 61-year-old immunocompetent patient due to Aspergillus nidulans that was successfully treated with a combination of extensive surgical debridement, spinal stabilization, and a prolonged course of antifungal therapy. Imaging demonstrated findings consistent with L3 discitis. The biopsy grew Aspergillus fungus and was treated with vorconizole. Imaging showed progressive destructive osteomyelitis at L3-L4. Patient underwent anterior L3 and L4 partial corpectomies, anterior interbody fusion L3-L5, and posterior T11-S2 pedicle screw and rod fixation. Antifungal treatment resulted in resolution of infection. Aspergillus markers remain negative. One year following definitive treatment, the patient’s back pain remains resolved. Conclusion. Definitive surgical resection of the infection, spinal stabilization, and aggressive antifungal therapy were required to eradicate the infection.
- Published
- 2019
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38. Design of Modular Smart Electric Fence System with Fall-back Communication Interface
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R Vikram, K M Jayaraju, and N Anusha
- Published
- 2023
39. Neuroinvasive West Nile virus infection in solid organ transplant recipients
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Sabirah N. Kasule, Simran Gupta, Roberto L. Patron, Marie F. Grill, and Holenarasipur R. Vikram
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Transplantation ,Infectious Diseases - Abstract
Literature on the natural course of neuroinvasive West Nile virus (WNV) infection in solid organ transplant (SOT) recipients is sparse. In the setting of a 2021 WNV outbreak in Arizona, we reviewed our institution's experience with neuroinvasive WNV infection in patients with SOT.We retrospectively identified SOT recipients treated for neuroinvasive WNV at Mayo Clinic in Arizona from 2007 through 2021. Clinical manifestations, disease course, and outcomes were analyzed.Among 24 SOT recipients with WNV infection identified during the study period, 13 infections occurred in 2021. Most patients had gastrointestinal tract symptoms and fever at disease presentation. Five patients had cognitive impairment, and 14 initially or eventually had acute flaccid paralysis. Clinically significant deterioration occurred at a median of 4 (range, 1-11) days after hospital admission. Seventeen patients (71%) were transferred to the intensive care unit, with 15 requiring mechanical ventilation. Initial cerebrospinal fluid analysis mainly demonstrated a neutrophil-predominant pleocytosis. Almost all patients (n = 23) were treated with intravenous immunoglobulin alone or in combination with interferon alfa-2b. Sixteen patients had clinical improvement, 4 of whom recovered completely. Six patients died during hospitalization due to complications of neuroinvasive WNV infection. Two patients were discharged to hospice without clinical recovery. The overall 30-day mortality rate was 36%.Despite advances in supportive care, neuroinvasive WNV infection is associated with substantial morbidity and mortality in SOT recipients. Flaccid paralysis is an indicator of poor prognosis. This article is protected by copyright. All rights reserved.
- Published
- 2023
40. 636. Meningococcal Vaccination and Antibiotic Prophylaxis Practices in Solid Organ Transplant Recipients undergoing Eculizumab Therapy
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Eric Bhaimia, Zachary A Yetmar, Maryam Mahmood, Bernard Stacy, Jenise Stephen, Holenarasipur R Vikram, and Lisa M Brumble
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Infectious Diseases ,Oncology - Abstract
Background Eculizumab, an inhibitor of terminal complement activation, has been utilized in pre-transplant desensitization, treatment of antibody-mediated rejection and thrombotic microangiopathy in solid organ transplant recipients (SOTR). Eculizumab is associated with meningococcal disease, leading to guidelines for vaccination against serogroups ACWY (menACWY) and B (menB) at least 2 weeks prior to eculizumab therapy. In persons requiring emergent use of eculizumab, prophylaxis for at least 2 weeks is recommended. SOTRs respond suboptimally to vaccination, raising consideration for pre-transplant vaccination and prolonged prophylaxis in those undergoing eculizumab therapy. We sought to describe meningococcal vaccination and prophylaxis practices among SOTRs receiving eculizumab. Methods We performed a retrospective chart review of meningococcal vaccination, including number and timing pre- or post-transplant, along with prophylaxis prescribing and duration in SOTRs receiving eculizumab across 3 distinct Mayo Clinic Enterprise sites (Rochester, Arizona, and Florida). Results 200 SOTRs receiving at least one dose of eculizumab between 1/1/2008 and 9/16/2021 were reviewed. Eculizumab indications included antibody mediated rejection (38%), desensitization (26%), and thrombotic microangiopathy (19%). 83% (166/200) of SOTRs received eculizumab for an unanticipated post-transplant complication. Vaccination rates were 82% (164/200) and 35.5% (71/200) for menACWY dose 1 and 2, respectively, and 54% (108/200) and 28.5% (57/200) for menB dose 1 and 2, respectively. The majority received their first vaccination post-transplant: menACWY 66.5% (133/200) and menB 2.5% (185/200). Among those without vaccination pre-eculizumab, 22.3% (41/184) were not prescribed prophylaxis. The median duration of prophylaxis was 62 (range 4-2651) days. Conclusion Most SOTRs underwent meningococcal vaccinations near the time of eculizumab administration post-transplant for an unanticipated complication. One-fifth of those meeting criteria were not provided meningococcal prophylaxis. These findings may support pre-transplant administration of meningococcal vaccinations and heightened awareness for meningococcal prophylaxis in SOTRs receiving eculizumab. Disclosures All Authors: No reported disclosures.
- Published
- 2022
41. 1029. Clinical Characteristics and Outcomes of Neuroinvasive West Nile Virus Infection in Immunocompromised and Immunocompetent Individuals
- Author
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Amir Mbonde, Gritsch David, Ehab Harahsheh, Sabirah N Kasule, Holenarasipur R Vikram, Shemonti Hasan, Richard Butterfield, and Marie Grill
- Subjects
Infectious Diseases ,Oncology - Abstract
Background Despite the increasing incidence of neuroinvasive West Nile virus (NiWNV) infection in the US, the spectrum of disease characteristics and neuroimaging findings in immunosuppressed (IS) individuals are not adequately described. We aimed to compare the clinical characteristics and outcomes of NiWNV infection in IS and immunocompetent (IC) patients. Methods We extracted relevant data from all NiWNV patients hospitalized 7/2003-10/2021 at Mayo Clinic hospitals. Cohort was inclusive of patients from the recent historic WNV outbreak in Arizona in 2021. Chi-Square or Kruskal-Wallis and logistic regression were used to compare relevant variables and determine predictors of mortality respectively. Results We included 115 patients (72 IC and 43 IS), mean age 63.5 years; neurologic syndromes included meningoencephalitis (85.2%), encephalomyelitis (8.7%) and myeloradiculitis (6.1%). Presenting symptoms were malaise (72%), fever (66%), altered mentation (64%), gastrointestinal (47%) and myalgia (35.7%). MRI brain was abnormal in 62.8% (49/78), demonstrating T2/FLAIR hyperintensities in 47.4% (brainstem, thalamus, temporal lobes), leptomeningeal enhancement (16.7%) and diffusion restriction (20.5%). Altered mental status (76.7% vs 56.9%), myalgia (44.4% vs. 20.9%), myoclonus (18.6% vs. 4.2%) and thalamic MRI T2 FLAIR abnormalities (11.4% vs 0%) were more common in IS patients. Higher CSF WBC counts were observed in IC vs IS patients (P< 0.05). Immunosuppressed patients were more likely to be treated with intravenous immunoglobulin (44.2% vs 8.3% p=< 0.001) and/or interferon therapy (32.6% vs 6.9%, p=0.0003) and had increased odds of 90-day mortality on multivariable analysis (Adjusted Odds Ratio, AOR 2.22; 95% CI 1.065-4.627, p=0.0334). In the IS subgroup, ICU admission, mechanical ventilation, and Glasgow coma scale of < 8 were associated with reduced overall survival/increased 90-day mortality (p< 0.005). Conclusion Individuals presenting in summer/fall months with the aforementioned symptoms and/or MRI abnormalities should be evaluated for NiWNV infection. Compared to the immunocompetent, immunosuppressed patients with NiWNV are at a significantly greater mortality risk. Novel and effective antiviral therapies aimed at improving outcomes are warranted. Disclosures All Authors: No reported disclosures.
- Published
- 2022
42. 1935. Cardiac Tamponade Following COVID-19 Vaccination
- Author
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Christopher B Murphy, Sabirah N Kasule, and Holenarasipur R Vikram
- Subjects
Infectious Diseases ,Oncology - Abstract
Background While numerous, most described cases of myocarditis and pericarditis following COVID-19 vaccination are mild and self-limited. We present two cases of life-threatening cardiac tamponade following COVID-19 vaccination. Methods Two cases of cardiac tamponade in temporal association with COVID-19 vaccination were reviewed Results Case 1 : 75-year-old male with rheumatoid arthritis admitted with chest pressure and hypotension 2 days after his 1st dose of Pfizer-BioNTech COVID-19 vaccine. Pericardiocentesis removed 275 ml of exudative effusion with 14,140 nucleated cells/ml. Fluid bacterial and fungal cultures were negative; cytology was inconsistent with malignancy. He had no Epstein-Barr virus (EBV) or cytomegalovirus (CMV) viremia. Symptoms resolved on prednisone and colchicine. A week later, he had an uneventful second COVID-19 vaccine. He went on to have 3 recurrences of pericarditis starting two months after his first. One was within 48 hours of his COVID-19 booster. He is on long term prednisone. Case 2: 66-year-old male with non-Hodgkin’s lymphoma in remission. He developed chest pain a day after his 2nd dose of Pfizer-BioNTech COVID-19 vaccine. Admitted 4 days later with pericardial effusion and managed medically. Readmitted a week later with fever and chest pain. Echocardiogram now showed cardiac tamponade. Pericardiocentesis removed 400 ml of exudative fluid with 1,191 nucleated cells/mL. Cultures for bacteria, fungi, and mycobacteria were negative. Cytology didn't show malignancy. Serologies for CMV, EBV and parvovirus represented past infection. He was discharged with a pericardial drain, colchicine, and NSAIDs. He was later readmitted with fevers. Echocardiogram only showed small pericardial effusion, which did not require drainage. Figure 1Circumferential pericardial effusion seen on trans-thoracic echocardiography from patient in case 1. Conclusion Given the proximity to COVID-19 vaccination and lack of alternative explanations, we believe that tamponade was a direct result of post-vaccine inflammatory pericarditis. Neither patient had a prior history of pericardial effusion. Both tested negative for SARS-CoV-2 by nasopharyngeal swab excluding active infection. Healthcare providers should consider the possibility of pericardial effusion and tamponade in patients with chest pain, shortness of breath, or hypotension following COVID-19 vaccination. Disclosures All Authors: No reported disclosures.
- Published
- 2022
43. 2096. Associations with Pneumocystis Pneumonia in Solid Organ Transplant Recipients: Impact of Posttransplant Lymphoproliferative Disorder
- Author
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Zachary A Yetmar, Dustin Duffy, Byron Smith, Holenarasipur R Vikram, Lisa M Brumble, Andrew H Limper, and Elena Beam
- Subjects
Infectious Diseases ,Oncology - Abstract
Background Pneumocystis jirovecii pneumonia (PCP) is a potentially deadly infection afflicting the immunocompromised population, including solid organ transplant recipients. Several risk factors have been described, including acute rejection, lymphopenia, and cytomegalovirus (CMV) infection. However, little is known regarding the risk imparted by posttransplant lymphoproliferative disorder (PTLD). Methods We performed a nested case-control study of solid organ transplant recipients diagnosed with PCP from 2000-2020. PCP was defined as positive smear or polymerase chain reaction testing with compatible clinical symptoms and radiographic findings. Two control were matched to each case by year of first transplant, first transplanted organ, and sex. Each control had at least as much follow-up from their transplant date to their matched case’s PCP diagnosis date. Multivariable conditional logistic regression was performed to analyze theorized risk factors. Results Sixty-seven cases met inclusion criteria and were matched to 134 controls (Table 1). Median age was 60.9 years, and the most common transplant type was kidney (52.2%). Fourteen patients had a history of PTLD, 12 of which developed PCP. All cases of PTLD were monomorphic, 6 were EBV-positive, 9 were receiving chemotherapy at the index date, and only 1 control patient was receiving PCP prophylaxis. The cases with PTLD developed PCP a median of 85 days after PTLD diagnosis, while the two controls were diagnosed more than 1 year earlier. After adjusting for age, acute rejection requiring treatment within the last 6 months, CMV infection within 6 months, current PCP prophylaxis, and lymphopenia (lymphocyte count < 0.5 x109/L) within 6 months, PTLD had a significant association with PCP (OR 14.0, 95% CI 1.7-114.5; p = .014). Lymphopenia was also associated with PCP (OR 8.2, 95% CI 3.2-20.7; p < .001), while the other factors were not. Table 1:Characteristics of 67 Solid Organ Transplant Recipients with Pneumocystis Pneumonia and 134 Matched Controls Conclusion Diagnosis of PTLD is independently associated with subsequent PCP after adjustment for recognized risk factors. This association is likely influenced by PTLD-directed chemotherapy, particularly regimens containing rituximab. PCP prophylaxis should be initiated in solid organ transplant recipients with PTLD, particularly those undergoing active therapy, and those with severe lymphopenia. Disclosures All Authors: No reported disclosures.
- Published
- 2022
44. A novel approach to naval architecture using 1G VLAN with RSTP.
- Author
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Zeba Syed, R. Vikram Raju, Sandeep Joshi, and Jeril Kuriakose
- Published
- 2014
- Full Text
- View/download PDF
45. A Review on Localization in Wireless Sensor Networks.
- Author
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Jeril Kuriakose, Sandeep Joshi, R. Vikram Raju, and Aravind Kilaru
- Published
- 2014
- Full Text
- View/download PDF
46. Needle preceding the scalpel in soft-tissue sarcomas - A case series.
- Author
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R., Vikram, M. V., Rashmi, Budihal, Nischita, and R., Kanaka
- Subjects
- *
SARCOMA , *MAGNETIC resonance imaging , *TUMOR grading , *TUMOR classification , *NEEDLE biopsy - Abstract
Soft-tissue sarcomas (STSs) are rare neoplasms that can be initially evaluated by fine-needle aspiration cytology (FNAC). Although they are difficult to subtype, these sarcomas can be graded and classified based on cytomorphology. FNAC, with clinical and radiological correlation, can be effectively used in the diagnosis of STSs. Application of ancillary techniques is essential to arrive at the final diagnosis. The aim of the study was to determine the efficacy of FNAC in the initial diagnosis of STSs. Three patients who presented with softtissue masses were initially evaluated by ultrasound and/or magnetic resonance imaging and FNAC. Following which, all the three cases were operated on and studied on histopathology and immunohistochemistry to arrive at a final diagnosis. All the three cases were diagnosed as malignant on FNAC even when radiology findings differed or was not confirmatory in one case. FNAC diagnosis was appropriate in case of grading of tumors and classification based on morphology in all the three cases. FNAC of soft-tissue tumors (STTs) is a quick, reliable, and cost-effective mode of initial investigation for STTs. Although it is difficult to subtype the diagnosis, in majority of the cases, a diagnosis of benign or malignant and grade of the tumor can be assessed. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
47. Improving Security in Cloud Data Using Paillier Homomorphic Encryption System
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N. Praveen Sundra Kumar, G. S. Nikhil, N. R. Vikram, and R. Deepa
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- 2022
48. Age Estimation in Social Network Using Machine Learning Algorithm
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R. Vikram, P. Nithish Kumar, S. Prasanth, S. Siva Sakthi Vel, and R. Surya
- Published
- 2022
49. Superimposed Neuroinvasive Coccidioidomycosis and West Nile Virus Infection
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Leah M Grant, Sabirah N Kasule, Madeline L Singer, Lisa J Speiser, and Holenarasipur R Vikram
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General Engineering - Published
- 2022
50. Infections following rejection therapies in kidney and liver transplant recipients
- Author
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Simran Gupta, Juan Gea‐Banacloche, Hay‐Me Me, David M. H. Chascsa, Raymond L. Heilman, Pooja Budhiraja, Reena N. Yaman, Holenarasipur R. Vikram, Nan Zhang, Anna M. Joseph, and Lavanya Kodali
- Subjects
Transplantation ,Infectious Diseases - Abstract
Infections are known complications of solid-organ transplant. Treatment for rejection may increase risk of infection. We aimed to study frequency of infection and identify the risk factors for infections in solid organ transplant (SOT) (liver and kidney) recipients treated for rejection.This is a retrospective chart review of all liver and kidney transplant recipients treated for rejection at our institution from 2014 to 2020. We collected information on episodes of acute rejection in the first year of transplant and infections within 6 months following rejection treatment.We identified 257 transplant patients treated for rejection. One hundred twelve (43.6%) developed infections, with a total of 226 infections. Urinary tracts infections were the most common, 72 (31.9%), followed by cytomegalovirus viremia in 37 (16.4%), bacteremia in 24 (10.6%), and BK virus in 14 (6.2%). Female sex (p = .047), elevated neutrophil count at rejection (p = .002), and increased number of rejection episodes (p = .022) were predictors of infection in kidney and simultaneous liver-kidney recipients. No specific type of induction or rejection therapy was identified as a risk factor for infection, likely due to the prophylaxis protocols at our institution. Infection post rejection treatment was associated with higher graft loss (p = .021) and mortality (p = .031) in kidney transplant recipients.Infections are common complications after treatment of SOT rejection. Female gender, higher neutrophil at time of rejection, and increased numbers of rejection episodes were predictors of infections after rejection in simultaneous liver-kidney and kidney transplant patients. Infections were predictors of graft loss at 6 months and mortality at any point in follow-up in kidney transplant patients.
- Published
- 2022
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