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The Comorbidity and Cognition in Multiple Sclerosis (CCOMS) study represents a coordinated effort by a team of clinicians, neuropsychologists, and neuroimaging experts to investigate the neural basis of cognitive changes and their association with comorbidities among persons with multiple sclerosis (MS). The objectives are to determine the relationships among psychiatric (e.g., depression or anxiety) and vascular (e.g., diabetes, hypertension, etc.) comorbidities, cognitive performance, and MRI measures of brain structure and function, including changes over time. Because neuroimaging forms the basis for several investigations of specific neural correlates that will be reported in future publications, the goal of the current manuscript is to briefly review the CCOMS study design and baseline characteristics for participants enrolled in the three study cohorts (MS, psychiatric control, and healthy control), and provide a detailed description of the MRI hardware, neuroimaging acquisition parameters, and image processing pipelines for the volumetric, microstructural, functional, and perfusion MRI data.

Background: With communication skills deemed increasingly important for engineering graduates, we wanted to understand how writing is currently included in engineering classes, what challenges are caused by including writing in such classes, and what resources would be most useful to help engineering instructors more easily include writing in engineering classes. Literature review: Writing is a necessary skill for engineering graduates and has received increased attention in engineering classes. However, despite many instructors’ beliefs that writing is an important skill for engineers, it is not typically taught in a systematic and comprehensive way across the engineering curriculum. Research questions: 1. What perceptions of writing, and specifically writing in engineering, do engineering instructors hold? 2. To what extent do engineering instructors report incorporation of writing activities and assignments in their classes? 3. What barriers do engineering instructors perceive as inhibiting the inclusion of more writing in engineering courses? 4. What resources do engineering instructors desire to expand and improve the inclusion of writing in engineering courses? Research methods: A survey was completed by engineering instructional staff (n = 190 respondents, 10.7% response rate) from seven institutions as well as by some members of the Big10+ Engineering Deans Mailing List. Instructors were asked about their general perceptions about writing in engineering and were also asked to consider the most recent engineering course that they taught and reflect on how they included (or did not include) writing in their course. Findings and conclusions: As expected, we found that most engineering instructional staff agree that writing skills are very important in engineering. Yet, we found that constraints on time and resources kept instructors from including more writing in their courses. This paper concludes with a discussion of our efforts to develop resources, such as rubrics, graded writing examples, and strategies for developing writing prompts, to help instructors include more writing in their engineering courses .

“Future Girls of STEM” is a university-sponsored, summer camp outreach program that was designed and implemented by an all-female faculty group to increase young girls’ interest in pursuing future careers in science, technology, engineering, and mathematics (STEM). This paper discusses the logistics and results of the pilot Future Girls of STEM camp, which was held in the summer of 2019 for seven to twelve-year-old girls. The four-day summer camp featured female engineers from local industry, who shared personal stories of their careers and helped campers work through engineering and leadership activities. Researchers assessed whether completing the activities increased participants’ understanding of, interest in, and self-efficacy in engineering topics, majors, and careers. Results showed an increased interest and self-reported understanding of engineering topics after participants completed the camp, as well as high self-efficacy throughout the camp experience. The Future Girls of STEM program, and its hands-on, interactive activities, can be transferred to other locations or universities with varying resources available.

A key strategy for the direct detection of sub-GeV dark matter is to search for small ionization signals. These can arise from dark matter-electron scattering or when the dark matter-nucleus scattering process is accompanied by a "Migdal" electron. We show that the theoretical descriptions of both processes are closely related, which allows for a principal mapping between dark matter-electron and dark matter-nucleus scattering rates once the dark matter interactions with matter are specified. We explore this parametric relationship for noble-liquid targets and, for the first time, provide an estimate of the "Migdal" ionization rate in semiconductors that is based on evaluating a crystal form factor that accounts for the semiconductor band structure. We also present new dark-matter-nucleus scattering limits down to dark matter masses of 500 keV using published data from XENON10, XENON100, and a SENSEI prototype Skipper-CCD. For a dark photon mediator, the dark matter-electron scattering rates dominate over the Migdal rates for dark matter masses below 100 MeV. We also provide projections for proposed experiments with xenon and silicon targets., 5 pages, 3 figures; journal version (with longer abstract), results unchanged

The Dark Matter Daily Modulation experiment (DMSQUARE) seeks for dark matter interactions with a Skipper CCD. It is currently running at surface level in Bariloche, Argentina, and will be moved to a shallow underground site at Sierra Grande, Argentina in November 2021. The low threshold achieved by Skipper CCDs allows to search for electron recoil events with an ionization energy down to 1.2 eV. In order to extract a potential dark matter signal from noise at the single electron level, we propose to search for a diurnal modulation of events, resulting from the potential interaction of the dark matter wind with the particles in the Earth. Depending on the model, mass and cross-section, this modulation can be maximum at 40deg of latitude in the Southern Hemisphere, where DMSQUARE is operated. In this article we present the experiment, report preliminary results with a prototype Skipper CCD taking data at surface level and comment on future prospects.

We propose a novel direct detection concept to search for dark matter with 100 keV to 100 MeV masses.Such dark matter can scatter off molecules in a gas and transfer anO(1) fraction of its kinetic energy to excitea vibrational and rotational state. The excited rovibrational mode relaxes rapidly and produces a spectacularmulti-infrared-photon signal, which can be observed with ultrasensitive photodetectors. We discuss in detail agas target consisting of carbon monoxide molecules, which enable efficient photon emission even at a relativelylow temperature and high vapor pressure. The emitted photons have an energy in the range 180 to 265 meV.By mixing together carbon monoxide molecules of different isotopes, including those with an odd numberof neutrons, we obtain sensitivity to both spin-independent interactions and spin-dependent interactions withthe neutron. We also consider hydrogen fluoride, hydrogen bromide, and scandium hydride molecules, whicheach provide sensitivity to spin-dependent interactions with the proton. The proposed detection concept can berealized with near-term technology and allows for the exploration of orders of magnitude of new dark matterparameter space.

We present new direct-detection constraints on eV-to-GeV dark matter interacting with electrons using a prototype detector of the Sub-Electron-Noise Skipper-CCD Experimental Instrument. The results are based on data taken in the MINOS cavern at the Fermi National Accelerator Laboratory. We focus on data obtained with two distinct readout strategies. For the first strategy, we read out the Skipper-CCD continuously, accumulating an exposure of 0.177 gram-days. While we observe no events containing three or more electrons, we find a large one- and two-electron background event rate, which we attribute to spurious events induced by the amplifier in the Skipper-CCD readout stage. For the second strategy, we take five sets of data in which we switch off all amplifiers while exposing the Skipper-CCD for 120k seconds, and then read out the data through the best prototype amplifier. We find a one-electron event rate of (3.51 +- 0.10) x 10^(-3) events/pixel/day, which is almost two orders of magnitude lower than the one-electron event rate observed in the continuous-readout data, and a two-electron event rate of (3.18 +0.86 -0.55) x 10^(-5) events/pixel/day. We again observe no events containing three or more electrons, for an exposure of 0.069 gram-days. We use these data to derive world-leading constraints on dark matter-electron scattering for masses between 500 keV to 5 MeV, and on dark-photon dark matter being absorbed by electrons for a range of masses below 12.4 eV., 5 pages, submitted to PRL

This study focuses on the calibration of an existing bio-geo-optical model for studying the spatial variability of water quality parameters including chlorophyll (CHL), non-algal particles (NAP), and colored dissolved organic matter (CDOM) in episodic river plumes. The geographic focus is the St. Joseph River plume in southern Lake Michigan. One set of EO-1 Hyperion imagery and one set of boat-based spectrometer measurements were successfully acquired to capture episodic plume events. Coincident water quality measurements were also collected during these plume events. In this study, a database of inherent optical properties (IOPs) measurements and spectral signatures was generated and used to calibrate the bio-geo-optical model. Field measured concentrations of NAP and CDOM at 67% of the sampled sites fall within one standard deviation of the retrieved means using the spectrometer measurements. The percentage of sites, 88%, is higher for the estimation of CHL concentrations. Despite the dynamic nature of the observed plume and the time lag during field sampling, 77% of the sampled sites show field measured CHL and NAP concentrations falling within one standard deviation of the Hyperion derived values. The spatial maps of water quality parameters generated from the Hyperion image provided a synoptic view of water quality conditions. Results show that concentrations of NAP, CHL, and CDOM were more than three times higher in conjunction with river outflow, and inside the river plumes, than in ambient water. It is concluded that the storm-initiated plume is a significant source of sediments, carbon and chlorophyll to Lake Michigan.

The Heavy Photon Search experiment took its first data in a 2015 engineering run using a 1.056 GeV, 50 nA electron beam provided by CEBAF at the Thomas Jefferson National Accelerator Facility, searching for a prompt, electroproduced dark photon with a mass between 19 and 81 MeV/c2. A search for a resonance in the e+e- invariant mass distribution, using 1.7 days (1170 nb-1) of data, showed no evidence of dark photon decays above the large QED background, confirming earlier searches and demonstrating the full functionality of the experiment. Upper limits on the square of the coupling of the dark photon to the standard model photon are set at the level of 6×10-6. Future runs with higher luminosity will explore new territory.

Writing has been identified as a critical skill and element of the engineering profession, yet it is rarely included in sophomore-level and junior-level courses. Textbooks often influence h...

We study the gravothermal evolution of dark matter halos in the presence of dissipative dark matter self-interactions. Dissipative interactions are present in many particle-physics realizations of the dark-sector paradigm and can significantly accelerate the gravothermal collapse of halos compared to purely elastic dark matter self-interactions. This is the case even when the dissipative interaction timescale is longer than the free-fall time of the halo. Using a semianalytical fluid model calibrated with isolated and cosmological $N$-body simulations, we calculate the evolution of the halo properties -- including its density profile and velocity dispersion profile -- as well as the core-collapse time as a function of the particle model parameters that describe the interactions. A key property is that the inner density profile at late times becomes cuspy again. Using 18 dwarf galaxies that exhibit a corelike dark matter density profile, we derive constraints on the strength of the dissipative interactions and the energy loss per collision., v2 as published in PRL

The Sub-Electron-Noise Skipper CCD Experimental Instrument (SENSEI) uses the recently developed Skipper-CCD technology to search for electron recoils from the interaction of sub-GeV dark matter particles with electrons in silicon. We report first results from a prototype SENSEI detector, which collected 0.019 gram-days of commissioning data above ground at Fermi National Accelerator Laboratory. These commissioning data are sufficient to set new direct-detection constraints for dark matter particles with masses between ~500 keV and 4 MeV. Moreover, since these data were taken on the surface, they disfavor previously allowed strongly interacting dark matter particles with masses between ~500 keV and a few hundred MeV. We discuss the implications of these data for several dark matter candidates, including one model proposed to explain the anomalously large 21-cm signal observed by the EDGES Collaboration. SENSEI is the first experiment dedicated to the search for electron recoils from dark matter, and these results demonstrate the power of the Skipper-CCD technology for dark matter searches., Comment: 5 pages + references, 4 figures, 1 table. V2 has additional references and minor clarifications. Published in PRL

We have developed ultralow-noise electronics in combination with repetitive, nondestructive readout of a thick, fully depleted charge-coupled device (CCD) to achieve an unprecedented noise level of 0.068 e- rms/pixel. This is the first time that discrete subelectron readout noise has been achieved reproducible over millions of pixels on a stable, large-area detector. This enables the contemporaneous, discrete, and quantized measurement of charge in pixels, irrespective of whether they contain zero electrons or thousands of electrons. Thus, the resulting CCD detector is an ultra-sensitive calorimeter. It is also capable of counting single photons in the optical and near-infrared regime. Implementing this innovative non-destructive readout system has a negligible impact on CCD design and fabrication, and there are nearly immediate scientific applications. As a particle detector, this CCD will have unprecedented sensitivity to low-mass dark matter particles and coherent neutrino-nucleus scattering, while future astronomical applications may include direct imaging and spectroscopy of exoplanets. Fil: Tiffenberg, Javier Sebastian. Fermi National Accelerator Laboratory; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina Fil: Sofo Haro, Miguel Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; Argentina. Comisión Nacional de Energía Atómica. Gerencia del Área de Energía Nuclear. Instituto Balseiro; Argentina. Fermi National Accelerator Laboratory; Estados Unidos Fil: Drlica Wagner, Alex. Fermi National Accelerator Laboratory; Estados Unidos Fil: Essig, Rouven. Stony Brook University; Estados Unidos Fil: Guardincerri, Yann. Fermi National Accelerator Laboratory; Estados Unidos Fil: Holland, Steve. Lawrence Berkeley National Laboratory; Estados Unidos Fil: Volansky, Tomer. Tel-Aviv University; Israel Fil: Yu, Tien Tien. Cern - European Organization For Nuclear Research; Suiza

We study in detail sub-GeV dark matter scattering off electrons in xenon, including the expected electron recoil spectra and annual modulation spectra. We derive improved constraints using low-energy XENON10 and XENON100 ionization-only data. For XENON10, in addition to including electron-recoil data corresponding to about $1-3$ electrons, we include for the first time events with $\gtrsim 4$ electrons. Assuming the scattering is momentum independent, this strengthens a previous cross-section bound by almost an order of magnitude for dark matter masses above 50 MeV. The available XENON100 data corresponds to events with $\gtrsim 4$ electrons, and leads to a constraint that is comparable to the XENON10 bound above 50 MeV. We demonstrate that a search for an annual modulation signal in upcoming xenon experiments (XENON1T, XENONnT, LZ) could substantially improve the above bounds even in the presence of large backgrounds. We also emphasize that in simple benchmark models of sub-GeV dark matter, the dark matter-electron scattering rate can be as high as one event every ten (two) seconds in the XENON1T (XENONnT or LZ) experiments, without being in conflict with any other known experimental bounds. While there are several sources of backgrounds that can produce single- or few-electron events, a large event rate can be consistent with a dark matter signal and should not be simply written off as purely a detector curiosity. This fact motivates a detailed analysis of the ionization-only ("S2-only") data, taking into account the expected annual modulation spectrum of the signal rate, as well as the DM-induced electron-recoil spectra, which are another powerful discriminant between signal and background., Comment: 5 pages + 4 pages appendices/references, 10 figures

We describe a novel search for MeV-to-GeV-mass dark matter, in which the dark matter scatters off electrons in a scintillating target. The excitation and subsequent de-excitation of the electron produces one or more photons, which could be detected with an array of cryogenic low-noise photodetectors, such as transition edge sensors (TES) or microwave kinetic inductance devices (MKID). Scintillators may have distinct advantages over other experiments searching for a low ionization signal from sub-GeV DM. First, the detection of one or a few photons may be technologically easier. Second, since no electric field is required to detect the photons, there may be far fewer dark counts mimicking a DM signal. We discuss various target choices, but focus on calculating the expected dark matter-electron scattering rates in three scintillating crystals, sodium iodide (NaI), cesium iodide (CsI), and gallium arsenide (GaAs). Among these, GaAs has the lowest band gap (1.52 eV) compared to NaI (5.9 eV) or CsI (6.4 eV), allowing it to probe dark matter masses possibly as low as ~0.5 MeV, compared to ~1.5 MeV with NaI or CsI. We compare these scattering rates with those expected in silicon (Si) and germanium (Ge). The proposed experimental concept presents an important complementary path to existing efforts, and its potential advantages may make it the most sensitive direct-detection probe of DM down to MeV masses., 5 pages + 8 pages of supplementary materials & references, 5 figures, 3 tables

We set conservative, robust constraints on the annihilation and decay of dark matter into various Standard Model final states under various assumptions about the distribution of the dark matter in the Milky Way halo. We use the inclusive photon spectrum observed by the Fermi Gamma-ray Space Telescope through its main instrument, the Large-Area Telescope (LAT). We use simulated data to first find the "optimal" regions of interest in the gamma-ray sky, where the expected dark matter signal is largest compared with the expected astrophysical foregrounds. We then require the predicted dark matter signal to be less than the observed photon counts in the a priori optimal regions. This yields a very conservative constraint as we do not attempt to model or subtract astrophysical foregrounds. The resulting limits are competitive with other existing limits, and, for some final states with cuspy dark-matter distributions in the Galactic Center region, disfavor the typical cross section required during freeze-out for a weakly interacting massive particle (WIMP) to obtain the observed relic abundance., 24 pages + appendices and references, 13 figures, accepted by PRD. Contact authors: Andrea Massari, Eder Izaguirre, and Rouven Essig

We present new constraints on sub-GeV dark matter and dark photons from the electron beam-dump experiment E137 conducted at SLAC in 1980-1982. Dark matter interacting with electrons (e.g., via a dark photon) could have been produced in the electron-target collisions and scattered off electrons in the E137 detector, producing the striking, zero-background signature of a high-energy electromagnetic shower that points back to the beam dump. E137 probes new and significant ranges of parameter space, and constrains the well-motivated possibility that invisibly decaying dark photons can explain the $\sim 3.6 \sigma$ discrepancy between the measured and SM value of the muon anomalous magnetic moment. It also restricts the parameter space in which the relic density of dark matter in these models is obtained from thermal freeze-out. E137 also convincingly demonstrates that (cosmic) backgrounds can be controlled and thus serves as a powerful proof-of-principle for future beam-dump searches for sub-GeV dark matter scattering off electrons in the detector., Comment: 5 pages + references , 2 figures. v2: Fig. 2 now contains all constraints from visible A' searches; note added

We perform an extensive survey of non-standard Higgs decays that are consistent with the 125 GeV Higgs-like resonance. Our aim is to motivate a large set of new experimental analyses on the existing and forthcoming data from the Large Hadron Collider (LHC). The explicit search for exotic Higgs decays presents a largely untapped discovery opportunity for the LHC collaborations, as such decays may be easily missed by other searches. We emphasize that the Higgs is uniquely sensitive to the potential existence of new weakly coupled particles and provide a unified discussion of a large class of both simplified and complete models that give rise to characteristic patterns of exotic Higgs decays. We assess the status of exotic Higgs decays after LHC Run 1. In many cases we are able to set new nontrivial constraints by reinterpreting existing experimental analyses. We point out that improvements are possible with dedicated analyses and perform some preliminary collider studies. We prioritize the analyses according to their theoretical motivation and their experimental feasibility. This document is accompanied by a website that will be continuously updated with further information: http://exotichiggs.physics.sunysb.edu., 179 pages + references and appendices, 36 figures, 21 tables. Slight updates to SM+S and 2HDM+S calculations and plots

We use modern jet-substructure techniques to propose LHC searches for multijet-resonance signals without leptons or missing energy. We focus on three-jet resonances produced by R-parity-violating decays of boosted gluinos, showing that shape analyses searching for a mass peak can probe such gluinos up to masses of ~ 750 GeV (650 GeV) with 20/fb (5/fb) at the LHC at 8 TeV. This complements existing search strategies, which also include counting methods that are inherently more prone to systematic uncertainties. Since R-parity-violating gluinos lighter than all squarks hadronize before decaying, we introduce new color-flow variables, "radial pull" and "axis contraction", which are sensitive to the color structure of the R-hadron's decay. The former measures the inward pull of subjets in a fat jet, while the latter quantifies the inward drift of the $N$-subjettiness axes when changing the distance measure. We show that they can dramatically improve the discrimination of a boosted gluino signal versus QCD, ttbar and combinatoric background for m_gluino ~ m_top. Cuts on axis contraction also noticeably improve the resonance shape for heavy gluinos with m_gluino > ~500 GeV. With minor adaptations, these variables could find application in substructure searches for particles in different color representations or with other decay topologies. We also compare how several different Monte Carlo generators model the high-multiplicity QCD background. This provides evidence that the discriminating power of our color-flow observables are robust, and provides useful guidance for future substructure studies., 21 pages, 13 figures, 3 tables. Added MC comparison for QCD background in Appendix

We present a search at the Jefferson Laboratory for new forces mediated by sub-GeV vector bosons with weak coupling α' to electrons. Such a particle A' can be produced in electron-nucleus fixed-target scattering and then decay to an e + e- pair, producing a narrow resonance in the QED trident spectrum. Using APEX test run data, we searched in the mass range 175-250 MeV, found no evidence for an A'→ e+ e- reaction, and set an upper limit of α'/α ~/= 10(-6). Our findings demonstrate that fixed-target searches can explore a new, wide, and important range of masses and couplings for sub-GeV forces.

We report the results of the observation of the nearby satellite galaxy Segue 1 performed by the MAGIC-I ground-based gamma-ray telescope between November 2008 and March 2009 for a total of 43.2 hours. No significant gamma-ray emission was found above the background. Differential upper limits on the gamma-ray flux are derived assuming various power-law slopes for the possible emission spectrum. Integral upper limits are also calculated for several power-law spectra and for different energy thresholds. The values are of the order of 10^{-11} ph cm^{-2}$ s^{-1} above 100 GeV and 10^{-12} ph cm^{-2} s^{-1} above 200 GeV. Segue 1 is currently considered one of the most interesting targets for indirect dark matter searches. In these terms, the upper limits have been also interpreted in the context of annihilating dark matter particles. For such purpose, we performed a grid scan over a reasonable portion of the parameter space for the minimal SuperGravity model and computed the flux upper limit for each point separately, taking fully into account the peculiar spectral features of each model. We found that in order to match the experimental upper limits with the model predictions, a minimum flux boost of 10^{3} is required, and that the upper limits are quite dependent on the shape of the gamma-ray energy spectrum predicted by each specific model. Finally we compared the upper limits with the predictions of some dark matter models able to explain the PAMELA rise in the positron ratio, finding that Segue 1 data are in tension with the dark matter explanation of the PAMELA spectrum in the case of a dark matter candidate annihilating into tau+tau-. A complete exclusion however is not possible due to the uncertainties in the Segue 1 astrophysical factor., Comment: 26 pages, 10 figures. Matched to published version

Experiments designed to measure neutrino oscillations also provide major opportunities for discovering very weakly coupled states. In order to produce neutrinos, experiments such as LSND collide thousands of Coulombs of protons into fixed targets, while MINOS and MiniBooNE also focus and then dump beams of muons. The neutrino detectors beyond these beam dumps are therefore an excellent arena in which to look for long-lived pseudoscalars or for vector bosons that kinetically mix with the photon. We show that these experiments have significant sensitivity beyond previous beam dumps, and are able to partially close the gap between laboratory experiments and supernovae constraints on pseudoscalars. Future upgrades to the NuMI beamline and Project X will lead to even greater opportunities for discovery. We also discuss thin target experiments with muon beams, such as those available in COMPASS, and show that they constitute a powerful probe for leptophilic PNGBs., 32 text pages, 5 figures, 4 tables

Dark matter (DM) particle annihilation or decay can produce monochromatic γ rays readily distinguishable from astrophysical sources. γ-ray line limits from 30 to 200 GeV obtained from 11 months of Fermi Large Area Space Telescope data from 20-300 GeV are presented using a selection based on requirements for a γ-ray line analysis, and integrated over most of the sky. We obtain γ-ray line flux upper limits in the range 0.6-4.5×10-9cm-2s-1, and give corresponding DM annihilation cross-section and decay lifetime limits. Theoretical implications are briefly discussed.

We provide conservative bounds on the dark matter cross-section and lifetime from final state radiation produced by annihilation or decay into charged leptons, either directly or via an intermediate particle $\phi$. Our analysis utilizes the experimental gamma-ray flux upper limits from four Milky Way dwarf satellites: HESS observations of Sagittarius and VERITAS observations of Draco, Ursa Minor, and Willman 1. Using 90% confidence level lower limits on the integrals over the dark matter distributions, we find that these constraints are largely unable to rule out dark matter annihilations or decays as an explanation of the PAMELA and ATIC/PPB-BETS excesses. However, if there is an additional Sommerfeld enhancement in dwarfs, which have a velocity dispersion ~10 to 20 times lower than that of the local Galactic halo, then the cross-sections for dark matter annihilating through $\phi$'s required to explain the excesses are very close to the cross-section upper bounds from Willman 1. Dark matter annihilation directly into $\tau$'s is also marginally ruled out by Willman 1 as an explanation of the excesses, and the required cross-section is only a factor of a few below the upper bound from Draco. Finally, we make predictions for the gamma-ray flux expected from the dwarf galaxy Segue 1 for the Fermi Gamma-ray Space Telescope. We find that for a sizeable fraction of the parameter space in which dark matter annihilation into charged leptons explains the PAMELA excess, Fermi has good prospects for detecting a gamma-ray signal from Segue 1 after one year of observation., Comment: 11 pages, 4 figures. References added. Final published version

A retrospective review of 115 randomly pulled hospital charts of patients admitted to the care of osteopathic physicians at an American Osteopathic Association-accredited primary care hospital revealed a significant decline in the frequency of structural examinations in history and physical examinations during a merger and relocation, as well as with increasing level of training of the examiner (chi 2 test, P.001). Attending physicians completed fewer structural examinations (45% of their history and physical examinations) compared to house staff (70%) and students (92%). A follow-up anonymous survey of 100 osteopathic physicians and students (response rate, 58%) revealed that the low overall frequency of structural examination completion (60%) was due primarily to attending physicians who considered this examination less relevant or impractical for their hospitalized patients. These results indicate that education on relevance of structural examination and manipulative treatment for acutely ill patients needs to be directed not only to house staff and students but also to attending physicians to preserve and improve the use of osteopathic principles at osteopathic hospitals.

The activity coefficient ratio for several indicators has been estimated for the protonated and neutral forms of the same indicator molecule over a large range of acidity in H2SO4, HClO4, and HCl systems. The activity coefficient (fB) of the neutral form of a number of Hammett indicators was determined via solubility measurements. The observed linear relationship between log fB and [Formula: see text] then permitted estimate by extrapolation of log fB not experimentally accessible for the more basic indicators. Solubility studies of the pentacyanopropenide (PCP−) salts of these more basic protonated indicators were referred to a reference standard, tetraethylammonium pentacyanopropenide (TEA+PCP−) according to the method developed by Boyd to obtain the activity coefficient ratio [Formula: see text] By synthesizing the term [Formula: see text] the approach to a meaningful value of [Formula: see text] is believed to be facilitated. This function is uniquely related to the water activity of the various acid systems examined to support the suggestion by Hammett that [Formula: see text] is a constant for primary aniline indicators at a specified acid concentration.

We explore a new low-threshold direct-detection concept for dark matter, based on the breaking of chemical bonds between atoms. This includes the dissociation of molecules and the creation of defects in a lattice. With thresholds of a few to 10s of eV, such an experiment could probe the nuclear couplings of dark matter particles as light as a few MeV. We calculate the expected rates for dark matter to break apart diatomic molecules, which we take as a case study for more general systems. We briefly mention ideas for how chemical-bond breaking might be detected in practice. We also discuss the possibility of detecting solar neutrinos, including pp neutrinos, with this experimental concept. With an event rate of $\mathcal{O}(0.1/\mathrm{kg}\text{\ensuremath{-}}\mathrm{year})$, large exposures are required, but measuring low-energy solar neutrinos would provide a crucial test of the solar model.