1. Histamine-induced suppressor cell function and nasal sensitivity in hay fever sufferers
- Author
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K. P. Jones, R. Fifefield, A. G. Fennerty, and Brian Davies
- Subjects
Adult ,Male ,Allergy ,Nasal Provocation Tests ,Adolescent ,Immunology ,In Vitro Techniques ,Lymphocyte Activation ,Immunoglobulin E ,medicine.disease_cause ,T-Lymphocytes, Regulatory ,chemistry.chemical_compound ,Pollen ,Concanavalin A ,otorhinolaryngologic diseases ,Humans ,Immunology and Allergy ,Medicine ,biology ,business.industry ,Rhinitis, Allergic, Seasonal ,Total ige ,medicine.disease ,Suppressor cell ,chemistry ,biology.protein ,Hay fever ,Female ,Plant Lectins ,business ,Histamine ,Function (biology) - Abstract
Summary Histamine-induced suppressor cell function was measured in a group of twenty-five hay fever suffers and sixteen non-atopic controls. No difference was found in the suppression index between sufferers and controls. There was, however, a significant relationship between the suppression index and nasal sensitivity to grass pollen, whether measured pre- or post-season, but no correlation between specific or total IgE levels and the suppression index. Histamine-induced suppressor cell function may influence pollen sensitivity in the most sensitive subjects, but not via an effect on IgE production.
- Published
- 1987
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