1. Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis
- Author
-
Massimo Zuin, Antonio Benedetti, Pierluigi Toniutto, Vincenzo Palmieri, Peter K. Gregersen, Cristina Rigamonti, Christopher I. Amos, Paolo Muratori, Barbara Coco, Francesca Bernuzzi, Piero Luigi Almasio, Renzo Montanari, Maurizia Rossana Brunetto, Fabio Macciardi, Andrea Galli, Pietro Andreone, Cameron N. Ghent, Yue Lu, Luca Fabris, Gideon M. Hirschfield, Marzia Margotti, Michael Ransom, Ilaria Bianchi, Agostino Colli, Carlo Selmi, Giancarlo Spinzi, Lory Saveria Crocè, S. Bruno, Gang Xie, Mario Strazzabosco, Claudio Tiribelli, Xiangdong Liu, Grazia Anna Niro, E. Jenny Heathcote, Russell Shigeta, Katherine A. Siminovitch, Elisabetta Borghesio, Nicola Caporaso, M. Eric Gershwin, Andrew Mason, Maria Vinci, Mauro Podda, Robert P. Myers, Fabio Marra, Cleofe Prisco, Lorenzo Morini, Roman Kosoy, Alberto Mattalia, Michael F. Seldin, Chun Xu, Maria Consiglia Bragazzi, Piero Portincasa, Roberta Lazzari, Giovanni Casella, Sonia Rossi, Marco Marzioni, Silvia Colombo, Domenico Alvaro, Luigi Muratori, Sara Lupoli, Carlo Ferrari, Annette Lee, Annarosa Floreani, Yan Lu, Floriano Rosina, Angelo Andriulli, Massimo Colombo, Antonio Picciotto, Kevork M. Peltekian, Ana Lleo, Alessandro Pisano, Pietro Invernizzi, Liu, X, Invernizzi, P, Lu, Y, Kosoy, R, Bianchi, I, Podda, M, Xu, C, Xie, G, Macciardi, F, Selmi, C, Lupoli, S, Shigeta, R, Ransom, M, Lleo, A, Lee, AT, Mason, AL, Myers, RP, Peltekian, KM, Ghent, CN, Bernuzzi, F, Zuin, M, Rosina, F, Borghesio, E, Floreani, A, Lazzari, R, Niro, G, Andriulli, A, Muratori, L, Muratori, P, Almasio, PL, Andreone, P, Margotti, M, Brunetto, M, Coco, B, Alvaro, D, Bragazzi, MC, Marra, F, Pisano, A, Rigamonti, C, Colombo, M, Marzioni, M, Benedetti, A, Fabris, L, Strazzabosco, M, Portincasa, P, Palmieri, VO, Tiribelli, C, Croce, L, Bruno, S, Rossi, S, Vinci, M, Prisco, C, Mattalia, A, Toniutto, P, Picciotto, A, Galli, A, Ferrari, C, Colombo, S, Casella, G, Morini, L, Caporaso, N, Colli, A, Spinzi, G, Montanari, R, Gregersen, PK, Heathcote, EJ, Hirschfield, GM, Siminovitch, KA, Amos, CI, Gershwin, ME, Seldin, MF, Lee, At, Mason, Al, Myers, Rp, Peltekian, Km, Ghent, Cn, Almasio, Pl, Bragazzi, Mc, Palmieri, Vo, Caporaso, Nicola, Gregersen, Pk, Heathcote, Ej, Hirschfield, Gm, Siminovitch, Ka, Amos, Ci, Gershwin, Me, Seldin, M. F., Lee, A, Mason, A, Myers, R, Peltekian, K, Ghent, C, Almasio, P, Bragazzi, M, Palmieri, V, Gregersen, P, Heathcote, E, Hirschfield, G, Siminovitch, K, Amos, C, Gershwin, M, Seldin, M, X., Liu, P., Invernizzi, Y., Lu, R., Kosoy, I., Bianchi, M., Podda, C., Xu, G., Xie, F., Macciardi, C., Selmi, S., Lupoli, R., Shigeta, M., Ransom, A., Lleo, A. T., Lee, A. L., Mason, R. P., Myer, K. M., Peltekian, C. N., Ghent, F., Bernuzzi, M., Zuin, F., Rosina, E., Borghesio, A., Floreani, R., Lazzari, G., Niro, A., Andriulli, L., Muratori, P., Muratori, P. L., Almasio, P., Andreone, M., Margotti, M., Brunetto, B., Coco, D., Alvaro, M. C., Bragazzi, F., Marra, A., Pisano, C., Rigamonti, M., Colombo, M., Marzioni, A., Benedetti, L., Fabri, M., Strazzabosco, P., Portincasa, V. O., Palmieri, Tiribelli, Claudio, Croce', Saveria, S., Bruno, S., Rossi, M., Vinci, C., Prisco, A., Mattalia, P., Toniutto, A., Picciotto, A., Galli, C., Ferrari, S., Colombo, G., Casella, L., Morini, N., Caporaso, A., Colli, G., Spinzi, R., Montanari, P. K., Gregersen, E. J., Heathcote, G. M., Hirschfield, K. A., Siminovitch, C. I., Amo, M. E., Gershwin, M. F., Seldin, Liu X, Invernizzi P, Lu Y, Kosoy R, Bianchi I, Podda M, Xu C, Xie G, Macciardi F, Selmi C, Lupoli S, Shigeta R, Ransom M, Lleo A, Lee AT, Mason AL, Myers RP, Peltekian KM, Ghent CN, Bernuzzi F, Zuin M, Rosina F, Borghesio E, Floreani A, Lazzari R, Niro G, Andriulli A, Muratori L, Muratori P, Almasio PL, Andreone P, Margotti M, Brunetto M, Coco B, Alvaro D, Bragazzi MC, Marra F, Pisano A, Rigamonti C, Colombo M, Marzioni M, Benedetti A, Fabris L, Strazzabosco M, Portincasa P, Palmieri VO, Tiribelli C, Croce L, Bruno S, Rossi S, Vinci M, Prisco C, Mattalia A, Toniutto P, Picciotto A, Galli A, Ferrari C, Colombo S, Casella G, Morini L, Caporaso N, Colli A, Spinzi G, Montanari R, Gregersen PK, Heathcote EJ, Hirschfield GM, Siminovitch KA, Amos CI, Gershwin ME, and Seldin MF.
- Subjects
Liver Cirrhosis ,Oncology ,Canada ,medicine.medical_specialty ,Cirrhosis ,European Continental Ancestry Group ,LOCI ,PRIMARY BILIARY CIRRHOSIS ,GENOME WIDE ASSOCIATION ,Genome-wide association study ,Locus (genetics) ,genetics, Genome, Genome-Wide Association Study, Humans, Interferon Regulatory Factors, Liver Cirrhosi ,Biology ,Biliary, Meta-Analysis as Topic, Odds Ratio ,White People ,Article ,Alleles, Canada, European Continental Ancestry Group ,primary biliary cirrhosi ,Primary biliary cirrhosis ,Meta-Analysis as Topic ,MED/12 - GASTROENTEROLOGIA ,IL12A ,Internal medicine ,Odds Ratio ,Genetics ,medicine ,Humans ,Allele ,genome ,genetics, Genome, Genome-Wide Association Study, Humans, Interferon Regulatory Factors, Liver Cirrhosis ,Alleles ,primary biliary cirrhosis, genome-wide meta-analyses ,Liver Cirrhosis, Biliary ,Biliary ,Odds ratio ,medicine.disease ,Interferon Regulatory Factors ,Cohort ,Genome-Wide Association Study - Abstract
A genome-wide association screen for primary biliary cirrhosis risk alleles was performed in an Italian cohort. The results from the Italian cohort replicated IL12A and IL12RB associations, and a combined meta-analysis using a Canadian dataset identified newly associated loci at SPIB (P = 7.9 × 10−11, odds ratio (OR) = 1.46), IRF5-TNPO3 (P = 2.8 × 10−10, OR = 1.63) and 17q12-21 (P = 1.7 × 10−10, OR = 1.38).
- Published
- 2010