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The development of reduced models provide efficient methods that can be used to perform short term experimental data analysis or narrow down the parametric range of more sophisticated numerical approaches. Reduced models are derived by simplifying the physics description with the goal of retaining only the essential ingredients required to reproduce the phenomena under study. This is the role of the gyro-fluid code FAR3d, dedicated to analyze the linear and nonlinear stability of Alfvén Eigenmodes (AE), Energetic Particle Modes (EPM) and magnetic-hydrodynamic modes as pressure gradient driven mode (PGDM) and current driven modes (CDM) in nuclear fusion devices. Such analysis is valuable for improving the plasma heating efficiency and confinement; this can enhance the overall device performance. The present review is dedicated to a description of the most important contributions of the FAR3d code in the field of energetic particles (EP) and AE/EPM stability. FAR3d is used to model and characterize the AE/EPM activity measured in fusion devices as LHD, JET, DIII-D, EAST, TJ-II and Heliotron J. In addition, the computational efficiency of FAR3d facilitates performing massive parametric studies leading to the identification of optimization trends with respect to the AE/EPM stability. This can aid in identifying operational regimes where AE/EPM activity is avoided or minimized. This technique is applied to the analysis of optimized configurations with respect to the thermal plasma parameters, magnetic field configuration, external actuators and the effect of multiple EP populations. In addition, the AE/EPM saturation phase is analyzed, taking into account both steady-state phases and bursting activity observed in LHD and DIII-D devices. The nonlinear calculations provide: the induced EP transport, the generation of zonal structures as well as the energy transfer towards the thermal plasma and between different toroidal/helical families. Finally, FAR3d is used to forecast the AE/EPM stability in operational scenarios of future devices as ITER, CFETR, JT60SA and CFQS as well as possible approaches to optimization with respect to variations in the most important plasma parameters.

Introduction The expression of sexuality in the adult with mental disorders depends on the early incorporation of factors for promoting social inclusion. It is fundamental that sexual educators and advisors, in addition to working with the clients, also work with close family members. Intervention programs should establish objectives for developing a positive attitude towards sexuality in people with mental disorders and improving self-esteem (Katz G,Salud Publica Mex. 2008;50 Suppl 2:s239-54). Challenge Achieving support for people with mental health problems and/or substance use disorder admitted to the Social Rehabilitation Process of a psychiatric hospital so that they develop their sexuality satisfactorily. The right to privacy must be taken into account. Objectives Promoting a healthy and satisfactory development of sexuality in people with severe mental disorders. Raising awareness among healthcare teams, families and legal representatives regarding the need and suitability for support. Introducing the concept of sexuality as a dignifying perspective. Promoting sexual education that avoids disadvantages and situations of abuse in the target group. Coordinating the continuity of the project with non-health social services after discharge. Hypothesis Possibility of receiving support in the development of sexuality through training, information and improvement in the management of emotions/feelings in people who express the need or willingness to receive it, will contribute to overcoming limitations or difficulties. Methods Detecting people who during 2021 wish to work on the objectives through the care team. Searching for community resources aimed at attending sexuality issues in people with mental health problems. Proposing the hospital a collaboration with a non-profit entity that develops a specialized program for attention to sexuality in disability. Coordination between Treatment team and Entity. Quantitative and qualitative assessment of one year of experience according to the parameters of the entity. Results 2022 People included Percentage of people admittedto the Income Unit (65) Detection concern sex-affectivity 5 7,69% Verbalized concern 3 4,61% Referral to the entity program 2 3,07% Conclusions All patients included have a diagnosis of psychosis. Experience was very positive for the participants. Community intervention projects that lead to an education in healthy and respectful relationships in the field of sexuality and affectivity are necessary. This would allow to prevent behaviours and situations at risk of abuse as well as social and emotional instability. Disclosure of Interest None Declared

Introduction Hospital at home for psychiatric patients is a new emerging resource of delivering acute mental health care in the community. The main objective of this program is to provide intense care to patients with severe mental disorders at home as an alternative to acute admission. Although home hospitalisation has begun to develop widely in recent years there is a notable lack of studies The CAEM Psychiatric Home Hospitalization Unit (HAD-CAEM) has been operating since 2018 and takes place in Santa Coloma de Gramenet; and from March 2022 also in a part of Badalona. Both are sociodemographically depressed areas near Barcelona. Objectives The aim of this study is to describe the characteristics of patients attended at the Psychiatric Home Hospitalization Unit of our hospital and to study differences according to area and place of referral. Methods Socio-demographic and clinical data were collected retrospectively at admission and discharge of all patients treated at HAD-CAEM between March 2022 to february 2023. Statistical analysis was performed by using SPSS program. Results 85 patients were included in the study. 45.9% were women. The mean age was 45.5 years (SD 15.58 years). The main diagnoses of the sample were psychosis and schizophrenia (38.8%), Bipolar disorder (23.53%), Depressive disorder (21.18%), schizoaffective disorder (8.24%) and others (8,24%). 54 (63.53%) patients were from Santa Coloma area and 35 (41.18%) from Badalona area. The total mean duration of admission was 40.22 days (SD 26.18 days), with a mean follow-up of 10.09 visits (SD 5.39 visits) and 2.41 teleassistence (SD 2.62). The mean duration of admission for Santa Coloma patients was 43.98 days (SD 28.59), and for Badalona patients 33.68 days (SD 20.13). Trend without significance is observed (t= 1.77, p=0.08) We found differences in the mean duration of admission according to referral location. Acute psychiatric unit 33.25 days (SD 18.06), Mental health Center 51.93 days (SD 33.45), Emergencies 34.28 days (SD 19.69) (F=5.1, p=0.008). Conclusions Sociodemografic and clinical característics obtained in our study are consistent with those reported in previous studies. The duration of admission of patients referred from the mental health center is longer than those referred from the acute psychiatric or emergency unit. Home hospitalization teams have been increasing in recent years, being an alternative to traditional hospitalization. Disclosure of Interest None Declared

The most relevant features of FLIPEC (Free fLow Iterative Plasma Equilibrium Code) are presented. This new code iteratively calculates free-boundary, axisymmetric ideal MHD equilibria with arbitrary poloidal and toroidal plasma flows. FLIPEC is a mature code that has emerged from a complete overhaul of a previous version (F-Torija Daza 2022 et al Nucl. Fusion 62 126044). It uses a (inverse) curvilinear coordinate representation for the Grad–Shafranov–Bernoulli equation system, which allows FLIPEC to extend its free-boundary capabilities to arbitrary plasma shapes and removes many limitations with regards to the distance between plasma and external coils. Run-time stabilization of vertical modes has also been implemented by means of artificial feedback coils. Finally, active targeting schemes have also been included. These capabilities are illustrated on two very different cases: the ITER tokamak baseline configuration and a NSTX spherical tokamak equilibrium.

Abstract Background Grafting is a technique widely used in horticulture that also has been applied in agriculture. In plant physiology, grafting facilitates the elucidation of mechanisms underlying growth and developmental processes, through the construction of chimeric plants with organs of different genotypes. Despite its small size, the model species Arabidopsis thaliana is very amenable for grafting, which can be useful to investigate transport of nutrients, amino acids or secondary metabolites between different tissues, or to investigate developmental processes depending on root-to-shoot communication, such as shoot branching, root and shoot plasticity upon shade avoidance, or disease resistance. Nevertheless, grafting protocols are usually technically challenging and training is required to achieve a reasonable success rate. Additionally, specialized tools and equipment are often needed, such as chips to accommodate the grafted plantlets or collars to maintain the contact between root and shoot. Results In this methodology paper, we provide a fast, easy, accessible, and specialized equipment-free protocol that enables high success ratios. Critical steps and notes are detailed, easing the implementation of the procedure for non-trained researchers. An example of the protocol application by three independent non-trained researchers shows that this method allows to achieve a 90–100% of grafting efficiency after 6 days post-grafting recovery. In addition, the grafting of Col-0 with the acs8x mutant, depleted in 1-aminocyclopropane-1-carboxylic acid (ACC), the biosynthetic precursor of the phytohormone ethylene, provides an example of the application of this optimized protocol, showing the suitability of the process to study long-distance transport processes. Conclusions We present an optimized protocol for hypocotyl grafting of 4-day-old Arabidopsis thaliana seedlings. The combination of conditions yields a grafting success of 90–100% and provides an easy and accessible methodology, reducing the time frame, and without the necessity of acquiring specialized equipment. The presented protocol is simple, fast and highly efficient, easing the inclusion of hypocotyl grafting assays in any research project. In addition, the description of the protocol is detailed to a level ensuring that even non-trained researchers, are sufficiently prepared to adopt the grafting methodology.

Introduction Severe mental illnesses characterized by periods of relapse that require intensive resource management. Caregivers of schizophrenia and bipolar disorder patients feel a considerable burden of care (Tanna et al. Ind Psychiatry J 2021, 30(2):299-304). The main objective of Hospital at home for psychiatric patients is to provide intense care to patients with severe mental disorders at home as an alternative to acute admission (Alba et al. Rev Psiquiatr Salud Ment. 2019, 12 (4) 207-212). Objectives The aim of this study is to describe the characteristics of patients attended at the Psychiatric Home Hospitalization Unit of our hospital (HAD-CAEM) and to assess the of burden of care that caregivers feel while giveing care to this patients. Methods Data were collected retrospectively at admission and discharge of all patients treated at HAD-CAEM between August 2018 to March 2022. Incomes of patients who met DSM-5 criteria for schizophrenia, bipolar disorder and major depressive disorder. Severity of disease and patient’s level of functionality was evaluated with the global assessment of functioning scale (GAF) and the Clinical Global Impression Scale (CGI). Burden Caregivers was evaluated with The Zarit Caregiver Burden Scale (ZCBS). Statistical analysis was performed by using SPSS program. Results 109 patients were included in the study. 49.5% were women. The mean age was 48 years (SD 18.47 years). 44% met criteria for schizophrenia, 25.7% for depressive disorder, and 30.3% for bipolar disorder. Most of them lived with their own family (47.7%); had secondary education (51.4%) and were unemployed (33%). 81% had a history of at least one admission to an acute psychiatric unit. The mean duration of admission in HAD-CAEM was 33.8 days (SD 15.72 days), with a mean follow-up of 8.75 visits (SD 3.58 visits). The mean CGI severity item at admission was 4.36 and there was an improvement at the time of discharge according to the CGI improvement item (mean CGI-I=2.43). The GAF scale on admission was 46.74 (SD 11.2) and on discharge 64.24 (SD 13.85), showing an improvement of 17.5 points at discharge (p

Introduction Traditionally, psychiatric wards had established a “locked door” policy but secluded conditions may increase patient’s discomfort1 that could affect the perception of health quality of care2. Recently, the “open-door” policy is being adopted in several European countries but its impact on patient satisfaction remains unknown (Schreiber, LK. BMC Psychiatry. 2019 May 14;19(1):149). Since 2019 our psychiatric hospital has implemented the open-door policy. Objectives The aim of this study is to investigate the impact of the “open-door” policy on patient satisfaction during their stay in the acute inpatient unit of our psychiatric hospital. Methods This is an observational study. Prior to the implementation of the open door policy 31 patient satisfaction data was collected between October 2018 to April 2019 and it was also assessed with 31 subjects between July to October 2019, after the implementation of the open “door-policy”. The inclusion criteria were being >18 years old, reading Spanish correctly and with a length of stay >72 hours. The patients with dementia disorder and intellectual disability where excluded from the study. We used the Satispsy-22-E scale, a self-administered questionnaire (Frías, V., et al. 2018. Psychiatry Res. Oct;268:8-14). It assesses patient’s experience of hospitalization through 22 items distributed into 6 dimensions. The score range is from 0 to 100. Differences in Satispsy-22-E scores were analysed by applying ANOVA using the IBM-SPSS (v. 25). Results Total scores in Satispsy-22 are provided in Figure 1. We found that patient satisfaction was increased in the dimensions of “personal experience” and “food” (p

Introduction Research shows the benefits of music therapy for various mental health conditions, including depression, trauma, and schizophrenia. Music acts as a medium for processing emotions, trauma, and grief. Playing instruments can encourage emotional expression, socialization and exploration of various therapeutic themes (i.e. conflict, communication, grief, etc.). Group music therapy, measured by questionnaires and described in qualitative interviews, improved quality of life and self-esteem for people with severe mental illness (SMI).Group singing and song writing provide creative options for social connections. Music therapy should be considered as a component of holistic care for people with SMI. Jungup Lee, Thyer BA. May 2013Journal of Human Behaviour in the Social Environment 23(5):597-609 Objectives Music therapy sessions are held in our hospital for people admitted to short-term hospitalization units and to psychosocial rehabilitation units. The goal of the sessions is to create a connection space, promote people’s confidence in their own resources for their recovery, and evoke valuable experiences and memories. Sometimes musicians from the community have been present in the sessions, contributing to overcoming the stigma towards mental illness. Methods We describe self-assessment of people admitted to psychiatric units after attending music therapy sessions. People from brief hospitalization unit filled out a survey, after each session, voluntarily, about their emotional state at the beginning of the session and after it. People from rehabilitation units, voluntarily filled the SRS V.3.0. 2002-Miller. Duncan & Johnson escale.The SRS was designed for use by clinicians to assess the therapeutic alliance during therapy (Duncan BL et al. The Session Rating Scale: Preliminary Psychometric Properties of a “Working” Alliance Measure JBT 3(1) 3-12 12/14/04 3:53 PM Page 3). Results 23 sessions took place for each unit. 39 patients from brief hospitalization, 22 women and 17 men, attended the sessions. 15 had a diagnosis of schizophrenia and related disorders, 13 were affective disorders, and 11 others diagnosis. All of them liked the participation either fully or partially. 76% men and 77% women felt better after, none of them reported to feel worse. 82% men and 86% women replied they would repeat the session. Patients from rehabilitation units were 7 women and 10 men. 14 had a schizophrenia related disorder and 3 had bipolar disorder. All items on the scale were scored above 9 over 10, (I felt heard, understood, and respected/ We worked on and talked about what I wanted to work on and talk about/ The therapist’s approach is a good fit for me) with an overall score of 9,62 over 10 (Overall, today’s session was right for me). Conclusions Music therapy sessions achieve benefits on an emotional level in any of the diagnoses, improving alliance with care teams, who value sessions as normalizing spaces, helping to overcome stigma. Disclosure of Interest None Declared

Introduction Since the beginning of the modern psychiatry the acute units have established a “locked door” policy. Some studies show that this condition may increase patient’s discomfort and affect the perception of health quality of care (Boyer L, 2009, Eur Psychiatry Dec;24(8):540-9). Lately, several European countries such as Germany, Switzerland and Spain are starting to implement the “open-door” policy but its impact on patient’s satisfaction is still unknown (Hochstrasser, L, Frontiers in Psychiatry, 9(57). https://doi.org/10.3389/fpsyt.2018.00057) . Objectives To help characterize the advantages of the “open-door” policy implemented in an acute inpatient psychiatric unit in order to assess the patient’s view of it. Methods This is a descriptive observational study carried out at an inpatient psychiatric unit. Data were collected after the implementation of the open door policy on June 2019, assessing the patient satisfaction of 31 subjects who completed the SATISPSY-22 scale at the time of discharge. Results are described using the average and its standard deviation. Results Results show scores in all items above 50 points, being the care team and the quality of care the most valued ones with 82 and 79 points respectively. The overall score is above 65 points (Fig. 1). Image: Conclusions In line with previous studies, our data suggests that the main impact of the “open-door” policy implementation is on patients’ perception of the care, being Quality of care and satisfaction with the Staff the items with highest scores. This could be explained by patients trusting more in the Care team, which would help enhance the therapeutic relationship improving therapeutic adherence, treatment adequacy and the outcome. Nevertheless, the Feeling related to hospitalisation was found to be the item with the lowest score. This could mean strategies should focus on improving patient’s insight regarding their clinical state and their need to be admitted. Our study supports the hypothesis that open-door policy in acute psychiatric units is seen positively by patients and that further research should be carried. Disclosure of Interest None Declared

The TROPOspheric Monitoring Instrument (TROPOMI) onboard the Sentinel-5 Precursor (S5P) satellite was launched on 13 October 2017 to provide the atmospheric composition for atmosphere and climate research. The S5P is a Sun-synchronous polar-orbiting satellite providing global daily coverage. The TROPOMI swath is 2600 km wide, and the ground resolution for most data products is 7.2×3.5 km2 (5.6×3.5 km2 since 6 August 2019) at nadir. The Finnish Meteorological Institute (FMI) is responsible for the development of the TROPOMI UV algorithm and the processing of the TROPOMI surface ultraviolet (UV) radiation product which includes 36 UV parameters in total. Ground-based data from 25 sites located in arctic, subarctic, temperate, equatorial and Antarctic areas were used for validation of the TROPOMI overpass irradiance at 305, 310, 324 and 380 nm, overpass erythemally weighted dose rate/UV index, and erythemally weighted daily dose for the period from 1 January 2018 to 31 August 2019. The validation results showed that for most sites 60 %–80 % of TROPOMI data was within ±20 % of ground-based data for snow-free surface conditions. The median relative differences to ground-based measurements of TROPOMI snow-free surface daily doses were within ±10 % and ±5 % at two-thirds and at half of the sites, respectively. At several sites more than 90 % of cloud-free TROPOMI data was within ±20 % of ground-based measurements. Generally median relative differences between TROPOMI data and ground-based measurements were a little biased towards negative values (i.e. satellite data < ground-based measurement), but at high latitudes where non-homogeneous topography and albedo or snow conditions occurred, the negative bias was exceptionally high: from −30 % to −65 %. Positive biases of 10 %–15 % were also found for mountainous sites due to challenging topography. The TROPOMI surface UV radiation product includes quality flags to detect increased uncertainties in the data due to heterogeneous surface albedo and rough terrain, which can be used to filter the data retrieved under challenging conditions.

In March 2017, measurements of downward global irradiance of ultraviolet (UV) radiation were started with a multichannel GUV-2511 radiometer in Marambio, Antarctica (64.23∘ S; 56.62∘ W), by the Finnish Meteorological Institute (FMI) in collaboration with the Servicio Meteorológico Nacional (SMN). These measurements were analysed and the results were compared to previous measurements performed at the same site with the radiometer of the Antarctic NILU-UV network during 2000–2008 and to data from five stations across Antarctica. In 2017/2018 the monthly-average erythemal daily doses from October to January were lower than those averaged over 2000–2008 with differences from 2.3 % to 25.5 %. In 2017/2018 the average daily erythemal dose from September to March was 1.88 kJ m−2, while in 2018/2019 it was 23 % larger (2.37 kJ m−2). Also at several other stations in Antarctica the UV radiation levels in 2017/2018 were below average. The maximum UV indices (UVI) in Marambio were 6.2 and 9.5 in 2017/2018 and 2018/2019, respectively, whereas during years 2000–2008 the maximum was 12. Cloud cover, the strength of the polar vortex and the stratospheric ozone depletion are the primary factors that influence the surface UV radiation levels in Marambio. The lower UV irradiance values in 2017/2018 are explained by the high ozone concentrations in November, February and for a large part of October. The role of cloud cover was clearly seen in December, and to a lesser extent in October and November, when cloud cover qualitatively explains changes which could not be ascribed to changes in total ozone column (TOC). In this study, the roles of aerosols and albedo are of minor influence because the variation of these factors in Marambio was small from one year to the other. The largest variations of UV irradiance occur during spring and early summer when noon solar zenith angle (SZA) is low and the stratospheric ozone concentration is at a minimum (the so-called ozone hole). In 2017/2018, coincident low total ozone column and low cloudiness near solar noon did not occur, and no extreme UV indices were measured.

A ground-based ultraviolet (GUV) multi-filter radiometer was set up at Marambio, 64∘ S, 56∘ W, Antarctica, in 2017. The instrument continuously measures ultraviolet (UV) radiation, visible (VIS) radiation and photosynthetically active radiation (PAR). The measurements are designed for providing high-quality long-term time series that can be used to assess the impact of global climate change in the Antarctic region. The quality assurance includes regular absolute calibrations and solar comparisons performed at Marambio and at Sodankylä, Finland. The measurements continue observations at Marambio that were performed with (Norwegian Institute for Air Re-search UV Radiometer (NILU-UV) radiometers between 2000 and 2010 as part of the Antarctic NILU-UV network. These measurements are ideally suited for assessing the effects of the ongoing stratospheric ozone recovery on the ecosystem, as the data products include information on radiation at various wavelengths ranging from UV to VIS so that changes on biologically effective radiation due to ozone can be separated from those due to other factors. Data products include total ozone, photosynthetically active radiation (PAR), visible (VIS) radiation at 555 nm, UV index, UV irradiance at 5 channels, UVB and UVA dose rate and daily dose, and biologically weighted UV dose rate and daily dose, calculated with 10 different action spectra. The data from the last 5 d and the daily maximum UV index time series are plotted and updated daily on the following web page: http://fmiarc.fmi.fi/sub_sites/GUVant/ (last access: 17 April 2020). The first 2 years of UV measurements were very different in terms of the results: for October, November and December the monthly average of daily maximum UVB dose rates were clearly higher in 2018 than in 2017. The largest difference was observed in October, when the average of daily maximum UVB dose rates was 76 and 102 µW cm−2 in 2017 and 2018, respectively. Monthly averages of the 3 months were similar in 2018, while in 2017 the monthly average of October was lower than those of November and December. The VIS and PAR time series show that daily maxima in 2018–2019 exceed those in 2017–2018 during late spring and summer (mid-November–January). The studied dataset, including daily maximum irradiances at five UV channels and one VIS channel; daily maximum UVB, UVA, and PAR dose rates; noon UVB, UVA, and PAR dose rates; noon total column ozone; and UVB and UVA daily doses, is freely accessible at https://doi.org/10.5281/zenodo.3688700 (Lakkala et al., 2019).

Introduction Patients with bipolar disorder (BD) have an increased risk for cardiovascular morbimortality. Clinical risk factors, specifically for arrhythmias and sudden cardiac death remain understudied. Objectives This study was conducted to assess differences in cardiac conduction among BD patients. Methods We included patients with BD in a cross-sectional design, confirmed by structured interview, age 18 through 80. Clinical characteristics were obtained using a structured questionnaire or medical records review. ECG intervals duration and morphology were manually assessed by cardiologists and compared among clinical subgroups using Chi-square, Mann-Whitney, and Kruskall-Wallis tests. Exploratory multivariable linear and logistic regression models were fitted to adjust for potential confounders. Results We included 117 patients (60.7% women, 76.9% bipolar I, 50% history of psychosis, 22.6% suicide attempts). We found a significantly longer QTc interval in BD patients with hypertension (difference: 9.5 ms, p=0.006), obesity (difference: 25 ms, p=0.001), and metabolic syndrome (difference: 13 ms, p=0.007). Hypertension remained a significant predictor of longer QTc after adjusting for age, gender, and antipsychotic use (estimate 17.718, p=0.018). We observed a significantly shorter PR interval in women (difference: 6 ms, p=0.029), early age of onset (difference 6 ms, p=0.025), non-users of lithium (difference 4 ms, p=0.002), and early trauma (difference 4 ms, p=0.038). Finally, we identified significant correlations between symptom severity, blood glucose and PR interval (r=0.298, p=0.001; r=0.278, p=0.003; respectively). Conclusions Patients with BD and hypertension may have an increased risk for QTc prolongation. Careful cardiovascular monitoring may be warranted. Disclosure No significant relationships.

IC 417 is in the Galactic plane, and likely part of the Aur OB2 association; it is ∼2 kpc away. Stock 8 is one of the densest cluster constituents; off of it to the east, there is a “nebulous stream” (NS) that is dramatic in the infrared (IR). We have assembled a list of literature-identified young stellar objects (YSOs), new candidate YSOs from the NS, and new candidate YSOs from IR excesses. We vetted this list via inspection of the images, spectral energy distributions (SEDs), and color–color/color–magnitude diagrams. We placed the 710 surviving YSOs and candidate YSOs in ranked bins, nearly two-thirds of which have more than 20 points defining their SEDs. The lowest-ranked bins include stars that are confused, or likely carbon stars. There are 503 in the higher-ranked bins; half are SED Class III, and ∼40% are SED Class II. Our results agree with the literature in that we find that the NS and Stock 8 are at about the same distance from Earth (as are the rest of the YSOs), and that the NS is the youngest region, with Stock 8 being a little older. We do not find any evidence for an age spread within the NS, consistent with the idea that the star formation trigger came from the north. We do not find that the other literature-identified clusters here are as young as either the NS or Stock 8; at best, they are older than Stock 8, and they may not all be legitimate clusters.

Solar ultraviolet (UV) irradiances were measured with NILU-UV multichannel radiometers at Ushuaia (54° S) and Marambio (64° S) between 2000 and 2013. The measurements were part of the Antarctic NILU-UV network, which was started in cooperation between Spain, Argentina and Finland. The erythemally weighted UV irradiance time series of both stations were analysed for the first time. The quality assurance procedures included a travelling reference instrument to transfer the irradiance scale to the stations. The time series were homogenized and high quality measurements were available for the period 2000–2010. During this period UV indices of 11 or more were measured on 5 and 35 days at Marambio and Ushuaia, respectively. At Marambio, the peak daily maximum UV index of 12 and daily doses of around 7 kJ m−2 were measured in November 2007. The highest UV daily doses at both stations were typically around 6 kJ m−2 and occurred when the stations were inside the polar vortex, resulting in very low total ozone amount. At both stations, daily doses in late November could even exceed those in the summer. At Marambio, in some years, also daily doses in October can be as high as those during the summer. At Ushuaia, the peak daily maximum UV index of 13 was measured twice: in November 2003 and 2009. Also during those days, the station of Ushuaia was inside the polar vortex.

Abstract Background The change from non-molecular to nucleic acid amplification tests (NAATs) is known to increase the detection of Clostridium difficile infection (CDI); however, the impact on stool rejection policies in clinical laboratories is unclear. The current guidelines have reinforced the importance of respecting strict conditions for performing tests on stool samples for CDI diagnosis. The purpose of this study was to estimate whether the implementation of molecular tests has resulted in changes in stool rejection policies between clinical laboratories that introduced NAATs and those that did not. Results A survey was conducted to evaluate the change in the number of stool samples rejected and the rejection criteria among 12 hospital laboratories in southwestern France before and after the switch from non-molecular tests to NAATs using retrospective data from June 1 till September 30, 2013 and the same period 2014. Four laboratories introduced NAATs as a second or third step in the process. A total of 1378 and 1297 stools samples were collected in 2013 and 2014, respectively. The mean number of rejected stool samples significantly increased (p

One of the quickest means of tsunami evacuation is transfer to higher ground soon after strong and long ground shaking. Ground shaking itself is a good initiator of the evacuation from disastrous tsunami. Longer period seismic waves are considered to be more correlated with the earthquake magnitude. We investigated the possible application of this to tsunami hazard alarm using single-site ground motion observation. Information from the mass media is sometimes unavailable due to power failure soon after a large earthquake. Even when an official alarm is available, multiple information sources of tsunami alert would help people become aware of the coming risk of a tsunami. Thus, a device that indicates risk of a tsunami without requiring other data would be helpful to those who should evacuate. Since the sensitivity of a low-cost MEMS (microelectromechanical systems) accelerometer is sufficient for this purpose, tsunami alarm equipment for home use may be easily realized. Amplitude of long-period (20 s cutoff) displacement was proposed as the threshold for the alarm based on empirical relationships among magnitude, tsunami height, hypocentral distance, and peak ground displacement of seismic waves. Application of this method to recent major earthquakes indicated that such equipment could effectively alert people to the possibility of tsunami.

The risk of exposure to Fasciola hepatica in horses from Uruguay was evaluated using ELISA and a recombinant surface protein (FhrAPS). Blood samples were collected from 368 horses from different districts. Detection of antibodies and the seasonal IgG pattern against the trematode was also established. The overall seroprevalence was 54% (ranging 23% November to 93% December). Significantly higher values were observed in the Anglo-Arab horses (86%) and in those older than xix year (63%). No sex- or origin-differences were observed. Two primary risk periods for infection in Uruguay have been identified, the end of spring and autumn. Exposure to the fluke should be taken into account among those horses feeding on pastures grazed by ruminants. Using FhrAPS-ELISA, helpful information concerning the risk of horses to the infection by trematode can be obtained. This test allows the opportunity to compare the results achieved in different laboratories by minimising specific regional effects.

Objective: Language brokering (LB) is an act of interpreting and translating that immigrants often engage in to help their family members who may not be fluent in the English language. The study examined whether adhering to Asian American values (i.e., values enculturation) could moderate the association between LB and internalizing symptoms (e.g., depression, anxiety) among Asian American college students. Participants & Methods: An online survey was administered to a sample of 159 Asian American college students who had engaged in LB. Results: Results from the moderation analysis indicated that Asian American values enculturation significantly buffered against the adverse effects of high LB frequency on internalizing symptoms after controlling for gender and generation status. Conclusions: The current study offered insights into the toll that LB could take on Asian American college students' mental health as well as the potential protective roles of values enculturation.

Introduction: The aim of this report is to describe our surgical technique of totally intracorporeal robotic assisted radical cystectomy (RARC) with neobladder formation. Materials and Methods: Between December 2003 and March 2013, a total of 147 patients (118 male, 29 female) underwent totally intracorporeal RARC for urinary bladder cancer. We also performed a systematic search of Medline, Embase and PubMed databases using the terms RARC, robotic cystectomy, robot-assisted, totally intracorporeal RARC, intracorporeal neobladder, intracorporeal urinary diversion, oncological outcomes, functional outcomes, and complication rates. Results: The mean age of our patients was 64 years (range 37-87). On surgical pathology 47% had pT1 or less disease, 27% had pT2, 16% had pT3 and 10% had pT4. The mean number of lymph nodes removed was 21 (range 0-60). 24% of patients had lymph node positive dAQ1isease. Positive surgical margins occurred in 6 cases (4%). Mean follow-up was 31 months (range 4-115 months). Two patients (1.4%) died within 90 days of their operation. Using Kaplan-Meier analysis, overall survival and cancer specific survival at 60 months was 68% and 69.6%, respectively. 80 patients (54%) received a continent diversion with totally intracorporeal neobladder formation. In the neobladder subgroup median total operating time was 420 minutes (range 265-760). Daytime continence and satisfactory sexual function or potency at 12 months ranged between 70-90% in both men and women. Conclusions: Our experience with totally intracorporeal RARC demonstrates acceptable oncological and functional outcomes that suggest this is a viable alternative to open radical cystectomy.

Introduction: Hallucinations are frequent in clinical practice, with an incidence of up to 38.7% in the general population. We aim to determine the prevalence of hallucinations among healthy young adults in our environment. Subjects and methods: We designed an observational study, using as subjects, third to sixth year medical students of the Universidad Complutense de Madrid who complete clinical rotations in the Hospital Clínico San Carlos. After a screening questionnaire, an individual interview was conducted via telephone or e-mail for those students who reported hallucinations. We obtained clinical and epidemiological data through a semi-structured clinical interview performed by a third year neurology resident. Results: N = 134 (average age was 22.1 years; 77.6% were women). 74 respondents answered affirmatively to one or more screening questions, and 54 completed the follow-up interview. 22.2% described visual phenomena and 64.8%, auditory. The majority reported sleep-related experiences and auditory perceptions related to hyper vigilance, such as hearing the telephone or the doorbell ring when in fact it had not (38.8%). All subjects had good insight and none had psychotic symptoms. Two cases were associated with substance abuse. Conclusions: Hallucinations are frequent among the general population. Traditionally, auditory phenomena have been associated with psychotic pathology, and other studies show a low population incidence (0.6%). However, in our sample, short auditory perceptions with immediate insight were frequent and not pathological. Resumen: Introducción: Las alucinaciones son frecuentes en la práctica clínica y presentan una incidencia poblacional de hasta el 38.7%. El objetivo del estudio es determinar la prevalencia de percepciones aberrantes entre jóvenes sanos de nuestro entorno. Sujetos y Métodos: Estudio observacional entre estudiantes de 3.° a 6.° curso de Medicina de la Universidad Complutense de Madrid que realizan prácticas en el Hospital Clínico San Carlos. Tras una encuesta de cribado, se realizó una entrevista individual a aquellos sujetos que presentaban percepciones aberrantes. Recogimos datos epidemiológicos mediante anamnesis semi-estructurada administrada por una residente de tercer año de Neurología. Resultados: N = 134 (edad media 22.1 años, 77.6% mujeres). 74 respondedores contestaron afirmativamente a alguna de las preguntas de screening y 54 completaron la entrevista. El 22.2% presentó fenómenos visuales y el 64.8% auditivos. La mayoría describieron fenómenos asociados al sueño y percepciones auditivas como oír el teléfono o el timbre de la puerta sin que hubieran sonado (38.8%). Todos presentaron crítica de los episodios y ninguno refirió síntomas psicóticos. Dos casos se asociaron a tóxicos. Conclusiones: Las percepciones aberrantes son muy frecuentes entre la población general. Clásicamente, se asocian los fenómenos auditivos a patología psicótica, y otros estudios dan una incidencia poblacional baja (0.6%). Sin embargo, en nuestra serie las percepciones auditivas de corta duración y con crítica inmediata eran frecuentes y no se asociaban a patología. Keywords: Hallucinations, Aberrant perceptions, Non-clinical population, Hypnagogic and hypnopompic hallucinations, Auditory hallucinations, Palabras clave: Alucinaciones, Percepciones aberrantes, Población general, Alucinaciones hipnagógicas e hipnopómpicas, Alucinaciones auditivas

Resumen: Introducción: Las alucinaciones son frecuentes en la práctica clínica y presentan una incidencia poblacional de hasta el 38,7%. El objetivo del estudio es determinar la prevalencia de percepciones aberrantes entre jóvenes sanos de nuestro entorno. Sujetos y métodos: Estudio observacional entre estudiantes de 3.° a 6.° curso de medicina de la Universidad Complutense de Madrid, que realizan prácticas en el Hospital Clínico San Carlos. Tras una encuesta de cribado, se realizó una entrevista individual a aquellos sujetos que presentaban percepciones aberrantes. Recogimos datos epidemiológicos mediante anamnesis semiestructurada administrada por una residente de tercer año de Neurología. Resultados: N = 134 (edad media 22,1 años, 77,6% mujeres); 74 respondedores contestaron afirmativamente a alguna de las preguntas de cribado y 54 completaron la entrevista. El 22,2% presentó fenómenos visuales y el 64,8% auditivos. La mayoría describieron fenómenos asociados al sueño y percepciones auditivas, como oír el teléfono o el timbre de la puerta sin que hubieran sonado (38,8%). Todos presentaron crítica de los episodios y ninguno refirió síntomas psicóticos. Dos casos se asociaron a tóxicos. Conclusiones: Las percepciones aberrantes son muy frecuentes entre la población general. Clásicamente, se asocian los fenómenos auditivos a patología psicótica y otros estudios dan una incidencia poblacional baja (0,6%). Sin embargo, en nuestra serie las percepciones auditivas de corta duración y con crítica inmediata eran frecuentes y no se asociaban a patología. Abstract: Introduction: Hallucinations are frequent in clinical practice, with an incidence of up to 38.7% in the general population. We aim to determine the prevalence of hallucinations among healthy young adults in our environment. Subjects and methods: We designed an observational study, using as subjects 3rd to 6th year medical students at the Universidad Complutense de Madrid who complete clinical rotations in the Hospital Clínico San Carlos. After a screening questionnaire, an individual interview was conducted via telephone or e-mail to those students who reported hallucinations. We obtained clinical and epidemiological data through a semi-structured clinical interview performed by a third year neurology resident. Results: N = 134 (average age was 22.1 years; 77.6% were women). 74 respondents answered affirmatively to one or more screening questions, and 54 completed the follow-up interview. 22.2% described visual phenomena and 64.8%, auditory. The majority reported sleep-related experiences and auditory perceptions related to hyper vigilance, such as hearing the telephone or the doorbell ring when in fact it had not (38.8%). All subjects had good insight into their experiences and none had psychotic symptoms. Two cases were associated with substance abuse. Conclusions: Hallucinations are frequent among the general population. Traditionally, auditory phenomena have been associated with psychotic pathology, and other studies show a low population incidence (0.6%). However, in our sample, short auditory perceptions with immediate analysis were frequent and not pathological. Palabras clave: Alucinaciones, Percepciones aberrantes, Población general, Alucinaciones hipnagógicas e hipnopómpicas, Alucinaciones auditivas, Keywords: Hallucinations, Aberrant perceptions, Non-clinical population, Hypnagogic and hypnopompic hallucinations, Auditory hallucinations

To determine the influence of slaughter transports carried out under commercial conditions, 162 pigs weighing 98 kg and of both sexes were studied. A total of seven transports were performed in summer and in winter conditions, with durations of 1 h and 13 h 15 min within each season. Cortisol, glucose, creatine phosphokinase (CPK), lactate dehydrogenase (LDH), albumin and total protein serum concentrations were measured. All variables increased during transport and decreased during lairage (P < 0.001), with cortisol values being 3.47 ± 0.19, 8.52 ± 0.28, and 6.96 ± 0.18 µg/dl at loading, unloading and exsanguinations, respectively, except for glucose (0.54 ± 0.03, 0.44 ± 0.04, and 0.86 ± 0.03 g/l). Short journeys did not allow the total recovery from the loading stress. A certain level of dehydration was observed, especially during lairage on the longest journeys (increase of 6.87 ± 1.29 g/l for total proteins; P < 0.01). Winter transports were slightly more stressful (P < 0.01 for cortisol and LDH, and P < 0.001 for CPK), with poorer recovery during lairage (CPK decrease being -141 ± 559 and -2 906 ± 730 IU/l for winter and summer journeys, respectively; P < 0.01). Females showed higher stress reactivity. Genetics modulated the effect of the rest of influencing factors, with Nn individuals showing a rougher reaction in short and winter conditions, but with lower dehydration levels. Under Mediterranean commercial conditions, stress in transported slaughter pigs was largely determined by season and genetics, so that an adaptation of handling procedures to these seasonal variations appears crucial if transport stress is to be reduced. Also, an improvement in stress resistance could be obtained by controlling the halothane gene of pigs.

This work presents the results of a study on the suitability of the clayey materials from Campos-RJ (Brazil) region for application in structural ceramic. The clayey materials, i.e. red clays available in this region, were selected so that their characteristics regarding chemical composition, rational analysis, X-ray diffraction, particle size analysis, thermal behavior, plasticity and as dried and fired properties could be studied. The results revealed that the studied samples are typically kaolinite based materials. In addition, it was found that almost all properties of these materials are led to the manufacture of structural ceramic. Mechanical strength test data resulted in Weibull distributions.

The objective of the present study was to determine the suitability of a swine breed with leptin resistance and predisposition to obesity (the Iberian pig) as model for studies on metabolic syndrome and type 2 diabetes. Thus, six Iberian sows had ad libitum access to food enriched with saturated fat (SFAD group; food consumption was estimated to be 4.5 kg/animal/day) whilst four females acted as controls and were fed with 2 kg/animal/day of a commercial maintenance diet. After three months of differential feeding, SFAD animals developed central obesity, dyslipidemia, insulin resistance and impaired glucose tolerance, and elevated blood pressure; the five parameters associated with the metabolic syndrome. Thus, the current study characterizes the Iberian pig as a robust, amenable, and reliable translational model for studies on nutrition-associated diseases.

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Declines in freshwater quality resulting from anthropogenic nutrient input remain a persistent issue worldwide. Yet, we still have a limited understanding of the magnitude and scale at which most lakes have been affected by human activities, namely Land Use/Land Cover (LULC) alterations. In response, the NSERC Canadian Lake Pulse Network has compiled the first nationwide systematic database of lake quality metrics by surveying 664 lakes across 12 ecozones over 3 years. To assess the influence of catchment development on water quality and its spatial variation, we built generally additive models and multivariate regressions to quantify the association between watershed LULC and lake temperature, Secchi depth, as well as chlorophyll-a, limiting nutrient, and ion concentrations. We found that agricultural and urban land use explained the greatest proportion of variation in water quality among LULC categories ([R.sup.2] = 0.20-0.29). Overall, our study highlights that drivers of water quality are similar across regions; however, baseline conditions vary, so freshwater ecosystem management strategies must consider their geographic context to better predict where water quality thresholds will be surpassed. Key words: agriculture, eutrophication, lake, multivariate regression tree, water quality, Introduction Despite decades of research into the drivers of lake water quality and evolving land management strategies, cultural eutrophication remains one of the leading threats to freshwater ecosystems across the [...]

Laboratory safety has received heightened attention due to a series of devastatingly tragic accidents in both academic and nonacademic settings. Consequently, chemistry departments at various academic institutions now offer some form of formal training in laboratory safety for entering graduate students. Although the extent of this training varies widely among institutions, it typically includes an online assessment and/or minimal in-person classroom instruction. However, a significant gap exists between a lecture hall setting and the complex environment that comprises an advanced research laboratory. We've adapted the technological advances in virtual and augmented reality to bridge this gap. A set of 360° virtual reality lab experiences, highlighting safety infractions, have been created for a variety of subdiscipline-distinct (medicinal, organic, inorganic, physical, drug screening) laboratory settings. Notable features include the accurate depiction of the visual complexity associated with research settings, the opportunity for the trainee to explore multiple laboratories in a self-paced fashion, and immediate feedback with respect to the identification of safety hazards. The VR Lab Safety modules were very well received by first year graduate students, with greater than 85% of the respondents describing the VR experience as engaging and memorable, as a good supplement to safety reading material, and as providing real world examples that are otherwise difficult to visualize.

Ref.: Can. J. Fish. Aquat. Sci. 00:1-13(2023) | dx.doi.org/10.11 39/cjfas-2023-0109. In Fig. 4 of the originally published article, the units for the bottom row of graphs were listed in [micro]g/L, [...]