1. ACE2 enhance viral infection or viral infection aggravate the underlying diseases
- Author
-
Qiyi Tang and Shaolei Teng
- Subjects
2019-20 coronavirus outbreak ,Coronavirus disease 2019 (COVID-19) ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,lcsh:Biotechnology ,RBD, Receptor binding domain ,Underlying diseases ,Biophysics ,SNP, Single Nucleotide Polymorphism ,PAH, pulmonary artery hypertension ,Single-nucleotide polymorphism ,Review Article ,CVD, cardiovascular disease ,Viral infection ,Biochemistry ,03 medical and health sciences ,0302 clinical medicine ,S, Spike: TMPRSS2, Transmembrane protease, serine 2 ,Structural Biology ,lcsh:TP248.13-248.65 ,Genetics ,Medicine ,Angiotensin converting enzyme 2 ,030304 developmental biology ,0303 health sciences ,Health disparity ,business.industry ,Spike Protein ,ACE2, Angiotensin converting enzyme 2 ,SARS-CoV-2, Severe Acute Respiratory Syndrome Coronavirus −2 SARS-CoV-2, Middle East Respiratory Syndrome 2: MERS-2 ,Acute cardiovascular disease ,Computer Science Applications ,030220 oncology & carcinogenesis ,Immunology ,Angiotensin-converting enzyme 2 ,COVID-19, Coronavirus Infectious Disease-19 ,R0, Reproductive number ,RAS, Renin-angiotensin system ,Single Nucleotide Polymorphism ,Coronavirus Infectious Disease-19 ,business ,ACEI, ACE inhibitor ,hormones, hormone substitutes, and hormone antagonists ,Biotechnology ,Severe Acute Respiratory Syndrome Coronavirus −2 - Abstract
ACE2 plays a critical role in SARS-CoV-2 infection to cause COVID-19 and SARS-CoV-2 spike protein binds to ACE2 and probably functionally inhibits ACE2 to aggravate the underlying diseases of COVID-19. The important factors that affect the severity and fatality of COVID-19 include patients' underlying diseases and ages. Therefore, particular care to the patients with underlying diseases is needed during the treatment of COVID-19 patients.
- Published
- 2020