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1. Source-specific nitrate intake and all-cause mortality in the Danish Diet, Cancer, and Health Study

Author

Bondonno, Nicola P., Pokharel, Pratik, Bondonno, Catherine P., Erichsen, Dorit W., Zhong, Liezhou, Schullehner, Jörg, Frederiksen, Kirsten, Kyrø, Cecilie, Hendriksen, Peter Fjeldstad, Hodgson, Jonathan M., Dalgaard, Frederik, Blekkenhorst, Lauren C., Raaschou-Nielsen, Ole, Sigsgaard, Torben, Dahm, Christina C., Tjønneland, Anne, and Olsen, Anja

Published
2024
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2. Long-term exposure to ambient air pollution and risk of lung cancer – A comparative analysis of incidence and mortality in four administrative cohorts in the ELAPSE study

Author

Chen, Jie, Atkinson, Richard W., Andersen, Zorana Jovanovic, Oftedal, Bente, Stafoggia, Massimo, Lim, Youn-Hee, Bekkevold, Terese, Krog, Norun Hjertager, Renzi, Matteo, Zhang, Jiawei, Bauwelinck, Mariska, Janssen, Nicole, Strak, Maciek, Forastiere, Francesco, de Hoogh, Kees, Rodopoulou, Sophia, Katsouyanni, Klea, Raaschou-Nielsen, Ole, Samoli, Evangelia, Brunekreef, Bert, Hoek, Gerard, and Vienneau, Danielle

Published
2024
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3. Residential exposure to transportation noise and risk of incident atrial fibrillation: a pooled study of 11 prospective Nordic cohorts

Author

Thacher, Jesse D., Roswall, Nina, Ögren, Mikael, Pyko, Andrei, Åkesson, Agneta, Oudin, Anna, Rosengren, Annika, Poulsen, Aslak H., Eriksson, Charlotta, Segersson, David, Rizzuto, Debora, Helte, Emilie, Andersson, Eva M., Aasvang, Gunn Marit, Engström, Gunnar, Gudjonsdottir, Hrafnhildur, Selander, Jenny, Christensen, Jesper H., Brandt, Jørgen, Leander, Karin, Overvad, Kim, Mattisson, Kristoffer, Eneroth, Kristina, Stucki, Lara, Barregard, Lars, Stockfelt, Leo, Albin, Maria, Simonsen, Mette K., Raaschou-Nielsen, Ole, Jousilahti, Pekka, Tiittanen, Pekka, Ljungman, Petter L.S., Jensen, Steen S., Gustafsson, Susanna, Yli-Tuomi, Tarja, Cole-Hunter, Thomas, Lanki, Timo, Lim, Youn-Hee, Andersen, Zorana J., Pershagen, Göran, and Sørensen, Mette

Published
2024
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4. Long-term exposure to air pollution and chronic kidney disease-associated mortality–Results from the pooled cohort of the European multicentre ELAPSE-study

Author

Kadelbach, Pauline, Weinmayr, Gudrun, Chen, Jie, Jaensch, Andrea, Rodopoulou, Sophia, Strak, Maciej, de Hoogh, Kees, Andersen, Zorana J., Bellander, Tom, Brandt, Jørgen, Cesaroni, Giulia, Fecht, Daniela, Forastiere, Francesco, Gulliver, John, Hertel, Ole, Hoffmann, Barbara, Hvidtfeldt, Ulla Arthur, Katsouyanni, Klea, Ketzel, Matthias, Leander, Karin, Ljungman, Petter, Magnusson, Patrik K.E., Pershagen, Göran, Rizzuto, Debora, Samoli, Evangelia, Severi, Gianluca, Stafoggia, Massimo, Tjønneland, Anne, Vermeulen, Roel, Peters, Annette, Wolf, Kathrin, Raaschou-Nielsen, Ole, Brunekreef, Bert, Hoek, Gerard, Zitt, Emanuel, and Nagel, Gabriele

Published
2024
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5. Long-term air pollution exposure and malignant intracranial tumours of the central nervous system: a pooled analysis of six European cohorts

Author

Hvidtfeldt, Ulla Arthur, Chen, Jie, Rodopoulou, Sophia, Strak, Maciej, de Hoogh, Kees, Andersen, Zorana J., Bellander, Tom, Brandt, Jørgen, Fecht, Daniela, Forastiere, Francesco, Gulliver, John, Hertel, Ole, Hoffmann, Barbara, Katsouyanni, Klea, Ketzel, Matthias, Leander, Karin, Magnusson, Patrik K. E., Nagel, Gabriele, Pershagen, Göran, Rizzuto, Debora, Samoli, Evangelia, So, Rina, Stafoggia, Massimo, Tjønneland, Anne, Weinmayr, Gudrun, Wolf, Kathrin, Zhang, Jiawei, Zitt, Emanuel, Brunekreef, Bert, Hoek, Gerard, and Raaschou-Nielsen, Ole

Published
2023
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6. Urban-Rural Differences in Schizophrenia Risk: Multilevel Survival Analyses of Individual- and Neighborhood-Level Indicators, Urbanicity and Population Density in a Danish National Cohort Study.

Author

Pedersen, Carsten, Antonsen, Sussie, Timmermann, Allan, Pedersen, Marianne, Ejlskov, Linda, Horsdal, Henriette, Agerbo, Esben, Webb, Roger, Raaschou-Nielsen, Ole, Sigsgaard, Torben, Sabel, Clive, Fan, Chun, and Thompson, Wesley

Subjects
general contextual effect, multilevel survival analyses, neighborhood-level domains, schizophrenia, specific contextual effect, urbanization
Abstract

BACKGROUND: Urban-rural differences in schizophrenia risk have been widely evidenced across Western countries. However, explanation of these differences is lacking. We aimed to identify contextual risk factors for schizophrenia that explain urban-rural differences in schizophrenia risk. METHODS: Utilizing Danish population-based registers, we partitioned Denmark into 1885 geographic neighborhoods homogeneously sized in terms of population. Information on the entire Danish population from 1981 to 2016 was used to quantify a spectrum of neighborhood-level domains. We subsequently conducted multilevel survival analyses following persons born in Denmark from 1971 to 1982 for the development of schizophrenia allowing for clustering of people within neighborhoods. We used this method to tease apart the effects of individual, specific, and general contextual risk factors for schizophrenia. RESULTS: A significant general contextual effect in schizophrenia risk across neighborhoods was estimated (Medium Incidence Rate Ratio (MRR):1.41; 95% CI:1.35-1.48). Most of the specific contextual factors examined were associated with schizophrenia risk. For instance, neighborhood-level proportion of lone adult households (Incidence Rate Ratios (IRR):1.53; 95% CI:1.44-1.63) had largest risk estimate. Adjustment for all individual-level and specific contextual constructs reduced the IRR for urbanicity from 1.98 (95% CI:1.77-2.22) to 1.30 (95% CI:1.11-1.51). CONCLUSIONS: In the largest prospective multilevel survival analyses of schizophrenia risk conducted to date, multiple neighborhood-level characteristics were associated with raised schizophrenia risk, with these contextual factors explaining most of the elevated risk linked with urbanicity. However, the unexplained heterogeneity that was evident in our multilevel models indicates that our understanding of the role of urbanicity in schizophrenias etiology remains incomplete.

Published
2022

7. Long-term exposure to ambient air pollution and risk of leukemia and lymphoma in a pooled European cohort

Author

Taj, Tahir, Chen, Jie, Rodopoulou, Sophia, Strak, Maciej, de Hoogh, Kees, Poulsen, Aslak Harbo, Andersen, Zorana J., Bellander, Tom, Brandt, Jørgen, Zitt, Emanuel, Fecht, Daniela, Forastiere, Francesco, Gulliver, John, Hertel, Ole, Hoffmann, Barbara, Hvidtfeldt, Ulla Arthur, Jørgensen, Jeanette T., Katsouyanni, Klea, Ketzel, Matthias, Lager, Anton, Leander, Karin, Liu, Shuo, Ljungman, Petter, Severi, Gianluca, Besson, Caroline, Magnusson, Patrik K.E., Nagel, Gabriele, Pershagen, Göran, Peters, Annette, Rizzuto, Debora, Samoli, Evangelia, Sørensen, Mette, Stafoggia, Massimo, Tjønneland, Anne, Weinmayr, Gudrun, Wolf, Kathrin, Brunekreef, Bert, Hoek, Gerard, and Raaschou-Nielsen, Ole

Published
2024
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8. Multiple myeloma risk in relation to long-term air pollution exposure - A pooled analysis of four European cohorts

Author

Hvidtfeldt, Ulla Arthur, Chen, Jie, Rodopoulou, Sophia, Strak, Maciej, de Hoogh, Kees, Andersen, Zorana J., Bellander, Tom, Brandt, Jørgen, Forastiere, Francesco, Brynedal, Boel, Hertel, Ole, Hoffmann, Barbara, Katsouyanni, Klea, Ketzel, Matthias, Leander, Karin, Magnusson, Patrik K.E., Nagel, Gabriele, Pershagen, Göran, Rizzuto, Debora, Samoli, Evangelia, So, Rina, Stafoggia, Massimo, Tjønneland, Anne, Weinmayr, Gudrun, Wolf, Kathrin, Zitt, Emanuel, Brunekreef, Bert, Hoek, Gerard, and Raaschou-Nielsen, Ole

Published
2023
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12. Exposure to long-term source-specific transportation noise and incident breast cancer: A pooled study of eight Nordic cohorts

Author

Thacher, Jesse D., Oudin, Anna, Flanagan, Erin, Mattisson, Kristoffer, Albin, Maria, Roswall, Nina, Pyko, Andrei, Aasvang, Gunn Marit, Andersen, Zorana J., Borgquist, Signe, Brandt, Jørgen, Broberg, Karin, Cole-Hunter, Thomas, Eriksson, Charlotta, Eneroth, Kristina, Gudjonsdottir, Hrafnhildur, Helte, Emilie, Ketzel, Matthias, Lanki, Timo, Lim, Youn-Hee, Leander, Karin, Ljungman, Petter, Manjer, Jonas, Männistö, Satu, Raaschou-Nielsen, Ole, Pershagen, Göran, Rizzuto, Debora, Sandsveden, Malte, Selander, Jenny, Simonsen, Mette K., Stucki, Lara, Spanne, Mårten, Stockfelt, Leo, Tjønneland, Anne, Yli-Tuomi, Tarja, Tiittanen, Pekka, Valencia, Victor H., Ögren, Mikael, Åkesson, Agneta, and Sørensen, Mette

Published
2023
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21. Long term exposure to air pollution and kidney parenchyma cancer – Effects of low-level air pollution: a Study in Europe (ELAPSE)

Author

Hvidtfeldt, Ulla Arthur, Taj, Tahir, Chen, Jie, Rodopoulou, Sophia, Strak, Maciej, de Hoogh, Kees, Andersen, Zorana J., Bellander, Tom, Brandt, Jørgen, Fecht, Daniela, Forastiere, Francesco, Gulliver, John, Hertel, Ole, Hoffmann, Barbara, Jørgensen, Jeanette T., Katsouyanni, Klea, Ketzel, Matthias, Lager, Anton, Leander, Karin, Ljungman, Petter, Magnusson, Patrik K.E., Nagel, Gabriele, Pershagen, Göran, Rizzuto, Debora, Samoli, Evangelia, So, Rina, Stafoggia, Massimo, Tjønneland, Anne, Vermeulen, Roel, Weinmayr, Gudrun, Wolf, Kathrin, Zhang, Jiawei, Zitt, Emanuel, Brunekreef, Bert, Hoek, Gerard, and Raaschou-Nielsen, Ole

Published
2022
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23. Exposure to surrounding greenness and natural-cause and cause-specific mortality in the ELAPSE pooled cohort

Author

Bereziartua, Ainhoa, Chen, Jie, de Hoogh, Kees, Rodopoulou, Sophia, Andersen, Zorana J., Bellander, Tom, Brandt, Jørgen, Fecht, Daniela, Forastiere, Francesco, Gulliver, John, Hertel, Ole, Hoffmann, Barbara, Arthur Hvidtfeldt, Ulla, Verschuren, W.M.Monique, Jöckel, Karl-Heinz, Jørgensen, Jeanette T, Katsouyanni, Klea, Ketzel, Matthias, Hjertager Krog, Norun, Brynedal, Boel, Leander, Karin, Liu, Shuo, Ljungman, Petter, Faure, Elodie, Magnusson, Patrik K.E., Nagel, Gabriele, Pershagen, Göran, Peters, Annette, Raaschou-Nielsen, Ole, Renzi, Matteo, Rizzuto, Debora, Samoli, Evangelia, van der Schouw, Yvonne T., Schramm, Sara, Severi, Gianluca, Stafoggia, Massimo, Strak, Maciej, Sørensen, Mette, Tjønneland, Anne, Weinmayr, Gudrun, Wolf, Kathrin, Zitt, Emanuel, Brunekreef, Bert, and Hoek, Gerard

Published
2022
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25. Long-term exposure to ambient air pollution and bladder cancer incidence in a pooled European cohort: the ELAPSE project

Author

Chen, Jie, Rodopoulou, Sophia, Strak, Maciej, de Hoogh, Kees, Taj, Tahir, Poulsen, Aslak Harbo, Andersen, Zorana J., Bellander, Tom, Brandt, Jørgen, Zitt, Emanuel, Fecht, Daniela, Forastiere, Francesco, Gulliver, John, Hertel, Ole, Hoffmann, Barbara, Hvidtfeldt, Ulla Arthur, Verschuren, W. M. Monique, Jørgensen, Jeanette T., Katsouyanni, Klea, Ketzel, Matthias, Lager, Anton, Leander, Karin, Liu, Shuo, Ljungman, Petter, Severi, Gianluca, Boutron-Ruault, Marie-Christine, Magnusson, Patrik K. E., Nagel, Gabriele, Pershagen, Göran, Peters, Annette, Rizzuto, Debora, van der Schouw, Yvonne T., Samoli, Evangelia, Sørensen, Mette, Stafoggia, Massimo, Tjønneland, Anne, Weinmayr, Gudrun, Wolf, Kathrin, Brunekreef, Bert, Raaschou-Nielsen, Ole, and Hoek, Gerard

Published
2022
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27. Dietary intakes of dioxins and polychlorobiphenyls (PCBs) and breast cancer risk in 9 European countries

Author

Fiolet, Thibault, Casagrande, Corinne, Nicolas, Geneviève, Horvath, Zsuzsanna, Frenoy, Pauline, Weiderpass, Elisabete, Katzke, Verena, Kaaks, Rudolf, Rodriguez-Barranco, Miguel, Panico, Salvatore, Sacerdote, Carlotta, Manjer, Jonas, Sonestedt, Emily, Grioni, Sara, Agudo, Antonio, Rylander, Charlotta, Haugdahl Nøst, Therese, Skeie, Guri, Tjønneland, Anne, Raaschou-Nielsen, Ole, Ardanaz, Eva, Amiano, Pilar, Dolores Chirlaque López, María, Schulze, Matthias B., Wennberg, Maria, Harlid, Sophia, Cairat, Manon, Kvaskoff, Marina, Huybrechts, Inge, and Romana Mancini, Francesca

Published
2022
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29. Long-term exposure to low ambient air pollution concentrations and mortality among 28 million people: results from seven large European cohorts within the ELAPSE project

Author

Stafoggia, Massimo, Oftedal, Bente, Chen, Jie, Rodopoulou, Sophia, Renzi, Matteo, Atkinson, Richard W, Bauwelinck, Mariska, Klompmaker, Jochem O, Mehta, Amar, Vienneau, Danielle, Andersen, Zorana J, Bellander, Tom, Brandt, Jørgen, Cesaroni, Giulia, de Hoogh, Kees, Fecht, Daniela, Gulliver, John, Hertel, Ole, Hoffmann, Barbara, Hvidtfeldt, Ulla A, Jöckel, Karl-Heinz, Jørgensen, Jeanette T, Katsouyanni, Klea, Ketzel, Matthias, Kristoffersen, Doris Tove, Lager, Anton, Leander, Karin, Liu, Shuo, Ljungman, Petter L S, Nagel, Gabriele, Pershagen, Göran, Peters, Annette, Raaschou-Nielsen, Ole, Rizzuto, Debora, Schramm, Sara, Schwarze, Per E, Severi, Gianluca, Sigsgaard, Torben, Strak, Maciek, van der Schouw, Yvonne T, Verschuren, Monique, Weinmayr, Gudrun, Wolf, Kathrin, Zitt, Emanuel, Samoli, Evangelia, Forastiere, Francesco, Brunekreef, Bert, Hoek, Gerard, and Janssen, Nicole A H

Published
2022
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31. Proximity to overhead power lines and childhood leukaemia: an international pooled analysis

Author

Amoon, Aryana T, Crespi, Catherine M, Ahlbom, Anders, Bhatnagar, Megha, Bray, Isabelle, Bunch, Kathryn J, Clavel, Jacqueline, Feychting, Maria, Hémon, Denis, Johansen, Christoffer, Kreis, Christian, Malagoli, Carlotta, Marquant, Fabienne, Pedersen, Camilla, Raaschou-Nielsen, Ole, Röösli, Martin, Spycher, Ben D, Sudan, Madhuri, Swanson, John, Tittarelli, Andrea, Tuck, Deirdre M, Tynes, Tore, Vergara, Ximena, Vinceti, Marco, Wünsch-Filho, Victor, and Kheifets, Leeka

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Pediatric, 2.1 Biological and endogenous factors, Aetiology, Adolescent, Child, Child, Preschool, Electric Power Supplies, Environmental Exposure, Female, Humans, Infant, Infant, Newborn, Leukemia, Magnetic Fields, Male, Residence Characteristics, Risk Factors, Public Health and Health Services, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

BackgroundAlthough studies have consistently found an association between childhood leukaemia risk and magnetic fields, the associations between childhood leukaemia and distance to overhead power lines have been inconsistent. We pooled data from multiple studies to assess the association with distance and evaluate whether it is due to magnetic fields or other factors associated with distance from lines.MethodsWe present a pooled analysis combining individual-level data (29,049 cases and 68,231 controls) from 11 record-based studies.ResultsThere was no material association between childhood leukaemia and distance to nearest overhead power line of any voltage. Among children living

Published
2018

32. Modelling ultrafine particle number concentrations at address resolution in Denmark from 1979 to 2018 - Part 2: Local and street scale modelling and evaluation

Author

Ketzel, Matthias, Frohn, Lise M., Christensen, Jesper H., Brandt, Jørgen, Massling, Andreas, Andersen, Christopher, Im, Ulas, Jensen, Steen Solvang, Khan, Jibran, Nielsen, Ole-Kenneth, Plejdrup, Marlene S., Manders, Astrid, Denier van der Gon, Hugo, Kumar, Prashant, and Raaschou-Nielsen, Ole

Published
2021
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37. Source-Specific Air Pollution Including Ultrafine Particles and Risk of Myocardial Infarction: A Nationwide Cohort Study from Denmark

Author

Poulsen, Aslak Harbo, Sorensen, Mette, Hvidtfeldt, Ulla Arthur, Christensen, Jesper H., Brandt, Jorgen, Frohn, Lise Marie, Ketzel, Matthias, Andersen, Christopher, and Raaschou-Nielsen, Ole

Subjects
Heart attack -- Risk factors -- Environmental aspects, Air pollution -- Health aspects -- Composition, Particles -- Environmental aspects -- Health aspects, Environmental issues, Health
Abstract

Background: Air pollution is negatively associated with cardiovascular health. Impediments to efficient regulation include lack of knowledge about which sources of air pollution contributes most to health burden and few studies on effects of the potentially more potent ultrafine particles (UFP). Objective: The authors aimed to investigate myocardial infarction (MI) morbidity and specific types and sources of air pollution. Methods: We identified all persons living in Denmark in the period 2005-2017, age >50 y and never diagnosed with MI. We quantified 5-y running time-weighted mean concentrations of air pollution at residencies, both total and apportioned to traffic and nontraffic sources. We evaluated particulate matter (PM) with aerodynamic diameter [less than or equal to] 2.5 [micro]m (P[M.sub.2.5]), Results: In this nationwide cohort of 1,964,702 persons (with 18 million person-years of follow-up and 71,285 cases of MI), UFP and P[M.sub.2.5] were associated with increased risk of MI with hazard ratios (HRs) per interquartile range (IQR) of 1.040 [95% confidence interval (CI): 1.025, 1.055] and 1.053 (95% CI: 1.035, 1.071), respectively. HRs per IQR of UFP and P[M.sub.2.5] from nontraffic sources were similar to the total (1.034 and 1.051), whereas HRs for UFP and P[M.sub.2.5] from traffic sources were smaller (1.011 and 1.011). The HR for EC from traffic sources was 1.013 (95% CI: 1.003, 1.023). N[O.sub.2] from nontraffic sources was associated with MI (HR = 1.048; 95% CI: 1.034, 1.062) but not from traffic sources. In general, nontraffic sources contributed more to total air pollution levels than national traffic sources. Conclusions: P[M.sub.2.5] and UFP from traffic and nontraffic sources were associated with increased risk of MI, with nontraffic sources being the dominant source of exposure and morbidity. https://doi.org/10.1289/EHP10556, Introduction A recent review of experimental and clinical studies concluded that air pollution can cause oxidative stress as well as local and systemic inflammation and that it affects vascular tone, [...]

Published
2023
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38. Long-term exposure to low-level ambient air pollution and incidence of stroke and coronary heart disease: a pooled analysis of six European cohorts within the ELAPSE project

Author

Wolf, Kathrin, Hoffmann, Barbara, Andersen, Zorana J, Atkinson, Richard W, Bauwelinck, Mariska, Bellander, Tom, Brandt, Jørgen, Brunekreef, Bert, Cesaroni, Giulia, Chen, Jie, de Faire, Ulf, de Hoogh, Kees, Fecht, Daniela, Forastiere, Francesco, Gulliver, John, Hertel, Ole, Hvidtfeldt, Ulla Arthur, Janssen, Nicole A H, Jørgensen, Jeanette T, Katsouyanni, Klea, Ketzel, Matthias, Klompmaker, Jochem O, Lager, Anton, Liu, Shuo, MacDonald, Conor J, Magnusson, Patrik K E, Mehta, Amar J, Nagel, Gabriele, Oftedal, Bente, Pedersen, Nancy L, Pershagen, Göran, Raaschou-Nielsen, Ole, Renzi, Matteo, Rizzuto, Debora, Rodopoulou, Sophia, Samoli, Evangelia, van der Schouw, Yvonne T, Schramm, Sara, Schwarze, Per, Sigsgaard, Torben, Sørensen, Mette, Stafoggia, Massimo, Strak, Maciek, Tjønneland, Anne, Verschuren, W M Monique, Vienneau, Danielle, Weinmayr, Gudrun, Hoek, Gerard, Peters, Annette, and Ljungman, Petter L S

Published
2021
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45. Modeling multi-level survival data in multi-center epidemiological cohort studies: Applications from the ELAPSE project

Author

Samoli, Evangelia, Rodopoulou, Sophia, Hvidtfeldt, Ulla A., Wolf, Kathrin, Stafoggia, Massimo, Brunekreef, Bert, Strak, Maciej, Chen, Jie, Andersen, Zorana J., Atkinson, Richard, Bauwelinck, Mariska, Bellander, Tom, Brandt, Jørgen, Cesaroni, Giulia, Forastiere, Francesco, Fecht, Daniela, Gulliver, John, Hertel, Ole, Hoffmann, Barbara, de Hoogh, Kees, Janssen, Nicole A.H., Ketzel, Matthias, Klompmaker, Jochem O., Liu, Shuo, Ljungman, Petter, Nagel, Gabriele, Oftedal, Bente, Pershagen, Göran, Peters, Annette, Raaschou-Nielsen, Ole, Renzi, Matteo, Kristoffersen, Doris T., Severi, Gianluca, Sigsgaard, Torben, Vienneau, Danielle, Weinmayr, Gudrun, Hoek, Gerard, and Katsouyanni, Klea

Published
2021
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46. Long-term exposure to fine particle elemental components and lung cancer incidence in the ELAPSE pooled cohort

Author

Hvidtfeldt, Ulla Arthur, Chen, Jie, Andersen, Zorana Jovanovic, Atkinson, Richard, Bauwelinck, Mariska, Bellander, Tom, Brandt, Jørgen, Brunekreef, Bert, Cesaroni, Giulia, Concin, Hans, Fecht, Daniela, Forastiere, Francesco, van Gils, Carla H., Gulliver, John, Hertel, Ole, Hoek, Gerard, Hoffmann, Barbara, de Hoogh, Kees, Janssen, Nicole, Jørgensen, Jeanette Therming, Katsouyanni, Klea, Jöckel, Karl-Heinz, Ketzel, Matthias, Klompmaker, Jochem O., Lang, Alois, Leander, Karin, Liu, Shuo, Ljungman, Petter L.S., Magnusson, Patrik K.E., Mehta, Amar Jayant, Nagel, Gabriele, Oftedal, Bente, Pershagen, Göran, Peter, Raphael Simon, Peters, Annette, Renzi, Matteo, Rizzuto, Debora, Rodopoulou, Sophia, Samoli, Evangelia, Schwarze, Per Everhard, Severi, Gianluca, Sigsgaard, Torben, Stafoggia, Massimo, Strak, Maciej, Vienneau, Danielle, Weinmayr, Gudrun, Wolf, Kathrin, and Raaschou-Nielsen, Ole

Published
2021
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48. Long-term low-level ambient air pollution exposure and risk of lung cancer – A pooled analysis of 7 European cohorts

Author

Hvidtfeldt, Ulla Arthur, Severi, Gianluca, Andersen, Zorana Jovanovic, Atkinson, Richard, Bauwelinck, Mariska, Bellander, Tom, Boutron-Ruault, Marie-Christine, Brandt, Jørgen, Brunekreef, Bert, Cesaroni, Giulia, Chen, Jie, Concin, Hans, Forastiere, Francesco, van Gils, Carla H., Gulliver, John, Hertel, Ole, Hoek, Gerard, Hoffmann, Barbara, de Hoogh, Kees, Janssen, Nicole, Jöckel, Karl-Heinz, Jørgensen, Jeanette Therming, Katsouyanni, Klea, Ketzel, Matthias, Klompmaker, Jochem O., Krog, Norun Hjertager, Lang, Alois, Leander, Karin, Liu, Shuo, Ljungman, Petter L.S., Magnusson, Patrik K.E., Mehta, Amar Jayant, Nagel, Gabriele, Oftedal, Bente, Pershagen, Göran, Peter, Raphael Simon, Peters, Annette, Renzi, Matteo, Rizzuto, Debora, Rodopoulou, Sophia, Samoli, Evangelia, Schwarze, Per Everhard, Sigsgaard, Torben, Simonsen, Mette Kildevæld, Stafoggia, Massimo, Strak, Maciek, Vienneau, Danielle, Weinmayr, Gudrun, Wolf, Kathrin, Raaschou-Nielsen, Ole, and Fecht, Daniela

Published
2021
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49. Long-term exposure to low-level air pollution and incidence of chronic obstructive pulmonary disease: The ELAPSE project

Author

Liu, Shuo, Jørgensen, Jeanette T., Ljungman, Petter, Pershagen, Göran, Bellander, Tom, Leander, Karin, Magnusson, Patrik K.E., Rizzuto, Debora, Hvidtfeldt, Ulla A., Raaschou-Nielsen, Ole, Wolf, Kathrin, Hoffmann, Barbara, Brunekreef, Bert, Strak, Maciej, Chen, Jie, Mehta, Amar, Atkinson, Richard W., Bauwelinck, Mariska, Varraso, Raphaëlle, Boutron-Ruault, Marie-Christine, Brandt, Jørgen, Cesaroni, Giulia, Forastiere, Francesco, Fecht, Daniela, Gulliver, John, Hertel, Ole, de Hoogh, Kees, Janssen, Nicole A.H., Katsouyanni, Klea, Ketzel, Matthias, Klompmaker, Jochem O., Nagel, Gabriele, Oftedal, Bente, Peters, Annette, Tjønneland, Anne, Rodopoulou, Sophia P., Samoli, Evangelia, Bekkevold, Terese, Sigsgaard, Torben, Stafoggia, Massimo, Vienneau, Danielle, Weinmayr, Gudrun, Hoek, Gerard, and Andersen, Zorana J.

Published
2021
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50. Long-term exposure to several constituents and sources of PM 2.5 is associated with incidence of upper aerodigestive tract cancers but not gastric cancer: Results from the large pooled European cohort of the ELAPSE project.

Author

Weinmayr, Gudrun, Chen, Jie, Jaensch, Andrea, Skodda, Lea, Rodopoulou, Sophia, Strak, Maciej, de Hoogh, Kees, Andersen, Zorana J, Bellander, Tom, Brandt, Jørgen, Fecht, Daniela, Forastiere, Francesco, Gulliver, John, Hertel, Ole, Hoffmann, Barbara, Hvidtfeldt, Ulla Arthur, Katsouyanni, Klea, Ketzel, Matthias, Leander, Karin, Magnusson, Patrik K E, Pershagen, Göran, Rizzuto, Debora, Samoli, Evangelia, Severi, Gianluca, Stafoggia, Massimo, Tjønneland, Anne, Vermeulen, Roel, Wolf, Kathrin, Zitt, Emanuel, Brunekreef, Bert, Thurston, George, Hoek, Gerard, Raaschou-Nielsen, Ole, Nagel, Gabriele, Weinmayr, Gudrun, Chen, Jie, Jaensch, Andrea, Skodda, Lea, Rodopoulou, Sophia, Strak, Maciej, de Hoogh, Kees, Andersen, Zorana J, Bellander, Tom, Brandt, Jørgen, Fecht, Daniela, Forastiere, Francesco, Gulliver, John, Hertel, Ole, Hoffmann, Barbara, Hvidtfeldt, Ulla Arthur, Katsouyanni, Klea, Ketzel, Matthias, Leander, Karin, Magnusson, Patrik K E, Pershagen, Göran, Rizzuto, Debora, Samoli, Evangelia, Severi, Gianluca, Stafoggia, Massimo, Tjønneland, Anne, Vermeulen, Roel, Wolf, Kathrin, Zitt, Emanuel, Brunekreef, Bert, Thurston, George, Hoek, Gerard, Raaschou-Nielsen, Ole, and Nagel, Gabriele

Abstract

It is unclear whether cancers of the upper aerodigestive tract (UADT) and gastric cancer are related to air pollution, due to few studies with inconsistent results. The effects of particulate matter (PM) may vary across locations due to different source contributions and related PM compositions, and it is not clear which PM constituents/sources are most relevant from a consideration of overall mass concentration alone. We therefore investigated the association of UADT and gastric cancers with PM 2.5 elemental constituents and sources components indicative of different sources within a large multicentre population based epidemiological study. Cohorts with at least 10 cases per cohort led to ten and eight cohorts from five countries contributing to UADT- and gastric cancer analysis, respectively. Outcome ascertainment was based on cancer registry data or data of comparable quality. We assigned home address exposure to eight elemental constituents (Cu, Fe, K, Ni, S, Si, V and Zn) estimated from Europe-wide exposure models, and five source components identified by absolute principal component analysis (APCA). Cox regression models were run with age as time scale, stratified for sex and cohort and adjusted for relevant individual and neighbourhood level confounders. We observed 1139 UADT and 872 gastric cancer cases during a mean follow-up of 18.3 and 18.5 years, respectively. UADT cancer incidence was associated with all constituents except K in single element analyses. After adjustment for NO 2, only Ni and V remained associated with UADT. Residual oil combustion and traffic source components were associated with UADT cancer persisting in the multiple source model. No associations were found for any of the elements or source components and gastric cancer incidence. Our results indicate an association of several PM constituents indicative of different sources with UADT but not gastric cancer incidence with the most robust evidence for traffic and residual oil combust

Published
2024

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