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8. Genome-wide occupancy reveals the localization of H1T2 (H1fnt) to repeat regions and a subset of transcriptionally active chromatin domains in rat spermatids

Author

Vasantha Shalini, Utsa Bhaduri, Anjhana C. Ravikkumar, Anusha Rengarajan, and Rao M. R. Satyanarayana

Subjects
Spermiogenesis, Linker histone, Spermatid, ChIP-sequencing, Histone PTMs, Genetics, QH426-470
Abstract

Abstract Background H1T2/H1FNT is a germ cell-specific linker histone variant expressed during spermiogenesis specifically in round and elongating spermatids. Infertile phenotype of homozygous H1T2 mutant male mice revealed the essential function of H1T2 for the DNA condensation and histone-to-protamine replacement in spermiogenesis. However, the mechanism by which H1T2 imparts the inherent polarity within spermatid nucleus including the additional protein partners and the genomic domains occupied by this linker histone are unknown. Results Sequence analysis revealed the presence of Walker motif, SR domains and putative coiled-coil domains in the C-terminal domain of rat H1T2 protein. Genome-wide occupancy analysis using highly specific antibody against the CTD of H1T2 demonstrated the binding of H1T2 to the LINE L1 repeat elements and to a significant percentage of the genic regions (promoter-TSS, exons and introns) of the rat spermatid genome. Immunoprecipitation followed by mass spectrometry analysis revealed the open chromatin architecture of H1T2 occupied chromatin encompassing the H4 acetylation and other histone PTMs characteristic of transcriptionally active chromatin. In addition, the present study has identified the interacting protein partners of H1T2-associated chromatin mainly as nucleo-skeleton components, RNA-binding proteins and chaperones. Conclusions Linker histone H1T2 possesses unique domain architecture which can account for the specific functions associated with chromatin remodeling events facilitating the initiation of histone to transition proteins/protamine transition in the polar apical spermatid genome. Our results directly establish the unique function of H1T2 in nuclear shaping associated with spermiogenesis by mediating the interaction between chromatin and nucleo-skeleton, positioning the epigenetically specialized chromatin domains involved in transcription coupled histone replacement initiation towards the apical pole of round/elongating spermatids.

Published
2021
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12. Large-Scale Compute-Intensive Constrained Optimization Problems: GPGPU-Based Approach

Author

Mane, Sandeep U., Narsinga Rao, M. R., Kacprzyk, Janusz, Series Editor, Pal, Nikhil R., Advisory Editor, Bello Perez, Rafael, Advisory Editor, Corchado, Emilio S., Advisory Editor, Hagras, Hani, Advisory Editor, Kóczy, László T., Advisory Editor, Kreinovich, Vladik, Advisory Editor, Lin, Chin-Teng, Advisory Editor, Lu, Jie, Advisory Editor, Melin, Patricia, Advisory Editor, Nedjah, Nadia, Advisory Editor, Nguyen, Ngoc Thanh, Advisory Editor, Wang, Jun, Advisory Editor, Ray, Kanad, editor, Sharma, Tarun K., editor, Rawat, Sanyog, editor, Saini, R. K., editor, and Bandyopadhyay, Anirban, editor

Published
2019
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23. Learning Hereditary and Reductive Prolog Programs from Entailment

Author

Hussain, Shahid, Rao, M. R. K. Krishna, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Goebel, Randy, editor, Siekmann, Jörg, editor, Wahlster, Wolfgang, editor, Huang, De-Shuang, editor, Jo, Kang-Hyun, editor, Lee, Hong-Hee, editor, Kang, Hee-Jun, editor, and Bevilacqua, Vitoantonio, editor

Published
2009
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26. A Class of Prolog Programs with Non-linear Outputs Inferable from Positive Data

Author

Rao, M. R. K. Krishna, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Dough, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Carbonell, Jaime G., editor, Siekmann, Jörg, editor, Jain, Sanjay, editor, Simon, Hans Ulrich, editor, and Tomita, Etsuji, editor

Published
2005
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27. Input-Termination of Logic Programs

Author

Krishna Rao, M. R. K., Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Dough, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, and Etalle, Sandro, editor

Published
2005
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28. Learnability of Simply-Moded Logic Programs from Entailment

Author

Rao, M. R. K. Krishna, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Dough, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, and Maher, Michael J., editor

Published
2005
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30. Inductive Inference of Term Rewriting Systems from Positive Data

Author

Rao, M. R. K. Krishna, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Dough, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Carbonell, Jaime G., editor, Siekmann, Jörg, editor, Ben-David, Shoham, editor, Case, John, editor, and Maruoka, Akira, editor

Published
2004
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31. DESIGN AND IMPLEMENTATION OF ENERGY EFFICIENT LIGHTWEIGHT ENCRYPTION (EELWE) ALGORITHM FOR MEDICAL APPLICATIONS

Author

Narasinga Rao M R, S. Venkateswarlu, and Radhika Rani Chintala

Subjects
FOS: Computer and information sciences, Computer Science - Cryptography and Security, Computer science, business.industry, Encryption, Base station, Data exchange, Server, The Internet, business, Cryptography and Security (cs.CR), Wireless sensor network, Algorithm, Efficient energy use, Block (data storage)
Abstract

Proportional to the growth in the usage of Human Sensor Networks (HSN), the volume of the data exchange between Sensor devices is increasing at a rapid pace. In this paper, we have proposed an Energy Efficient Lightweight Encryption (EELWE) algorithm for providing the confidentiality of data at the sensor level, particularly suitable for resource-constrained environments. Results obtained have proved that an EELWE consumes less energy relative to present lightweight ciphers and it supports multiple block sizes of 32-bit, 48-bit, and 64-bit., 11 pages

Published
2021
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46. Incremental learning of logic programs

Author

Rao, M. R. K. Krishna, Carbonell, Jaime G., editor, Siekmann, Jörg, editor, Goos, G., editor, Hartmanis, J., editor, van Leeuwen, J., editor, Jantke, Klaus P., editor, Shinohara, Takeshi, editor, and Zeugmann, Thomas, editor

Published
1995
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