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ObjectivesThe high-efficiency internal cooling technology of turbine blade is crucial for improving the thermal efficiency of gas turbine. As an important component of the gas turbine, it is essential to conduct research on the cooling performance of rotor blade. Due to significant effect of Coriolis force, buoyancy force, and channel structure on the cooling performance of rotating internal channel of turbine blade, this paper summarized the research status and development trends of rotating internal cooling channel based on these effect factors.MethodsA new structural design of rotating internal cooling channels was introduced, and a new rotating internal cooling channel structure suitable for double-walled blade configurations was proposed.ConclusionsDouble-sided enhanced U-shaped channels can utilize the enhanced heat transfer effect of Coriolis force, resulting in better cooling performance than traditional rotating U-shaped channels. There is a broad room for improvement in the internal cooling of gas turbine rotor blades.

AIM: To investigate the clinical efficacy and safety of XEN drainage tube implantation combined with mitomycin C(MMC)for open angle glaucoma(OAG).METHODS:A total of 37 OAG patients(37 eyes)were retrospectively included, grouped by anti-glaucoma surgical treatment as the first choice or not, with 17 patients(17 eyes)in the group with primary surgical treatment, and 20 patients(20 eyes)in the group with the numerous surgeries. The intraocular pressure(IOP), kinds of IOP-lowering drugs, and complications were collected and analyzed in 1 a follow-up postoperatively.RESULTS:Upon the one-year follow-up, IOP had decreased from 27.56±9.94, 28.43±14.18 mmHg to 15.16±3.65, 17.18±5.83 mmHg in both groups, respectively, representing a reduction of 55.01% and 60.43%, respectively(t=4.863, P

In the context of brain science research strategy in China, transcranial magnetic stimulation, as an input brain-computer interface technology, is able to improve the pathology of patients with mental disorders in a noninvasive way. However, new risks arising from the new technology have been ignored by the legislation, and there is a risk of privacy leaks of the neurological data presented by the patient's brain. The legal issues of physicians neglecting to inform patients of the risks of personality changes and the off-lable use of transcranial magnetic stimulation devices need to be explored. The legal issues of physicians neglecting to inform patients of the risks of personality changes and off-label use of transcranial magnetic stimulator devices need to be urgently explored. Multidisciplinary literature in the fields of trade-off between the right to health and privacy protection, principle of informed consent, data and application of off-label use for devices was searched and analyzed by using literature review and case analysis methods, to summarize the key points of the adjudication documents on off-label use for transcranial magnetic stimulation devices. It was found that the legal interpretations and value balances between the right to health and protection of privacy, physician's right of diagnosis and treatment and patient's right of informed consent, as well as the accessibility and safety of the devices, should be clarified and the adequate notification of new risks in the application of new technologies should be improved; it should be clarified that physicians and medical institutions should respect the privacy of the patients and the obligation to protect the security of neurological data, expand the scope of risk notification, clarify the risks of personality, prohibit the off-label use of the devices and establish a mechanism for risk analysis and dynamic monitoring of adverse reactions.

PurposeThis meta-analysis evaluates the comparative diagnostic efficacy of 68Ga-prostate-specific membrane antigen-11 PET (68Ga-PSMA-11 PET) and multiparametric MRI (mpMRI) for the initial lymph node staging of prostate cancer.MethodsWe searched PubMed and Embase databases through October 2023 for studies that provide a head-to-head comparison of 68Ga-PSMA-11 PET and mpMRI, using pelvic lymph node dissection as the gold standard. We assessed sensitivity and specificity using the DerSimonian and Laird method, with variance stabilization via the Freeman-Tukey double inverse sine transformation. The quality of included studies was evaluated using the Quality Assessment of Diagnostic Performance Studies (QUADAS-2) tool.ResultsThe meta-analysis incorporated 13 articles, involving a total of 1,527 patients. 68Ga-PSMA-11 PET demonstrated an overall sensitivity of 0.73 (95% CI: 0.51–0.91) and a specificity of 0.94 (95% CI: 0.88–0.99). In comparison, mpMRI showed a sensitivity of 0.49 (95% CI: 0.30–0.68) and a specificity of 0.94 (95% CI: 0.88–0.99). Although 68Ga-PSMA-11 PET appeared to be more sensitive than mpMRI, the differences in sensitivity (p = 0.11) and specificity (p = 0.47) were not statistically significant.ConclusionOur findings indicated that 68Ga-PSMA-11 PET and mpMRI exhibit similar sensitivity and specificity in the diagnosis of initial lymph node staging of prostate cancer. However, given that most included studies were retrospective, further prospective studies with larger sample sizes are essential to validate these results.Systematic Review RegistrationPROSPERO code is CRD42023495266.

Abstract： Computer text analysis is an important branch in the field of natural language processing, and it is a computer technology that studies how to extract various types of information from a given corpus from text data. At present, computer text analysis has entered a new historical stage. On the one hand, the keyword extraction algorithm has gradually been completed. On the other hand, with the emergence of the BERT method, the word vector calculation problem has also made great progress. However, there are still some problems to be solved in both keyword extraction and word vector calculation. In addition, many existing studies suitable for using text analysis still use ancient text analysis methods. Therefore, in the future, how to better reduce the model size to promote the integration of disciplines and improve the comprehensive social benefits of text analysis will become an important issue in the development of text analysis algorithms.

With the rapid development of civil aviation industry, more and more tasks are required to fuel the aircraft. At present, the aircraft refueling task is mainly assigned to the refueling personnel by the dispatcher of the fuel supplier, one by one, according to the flight refueling information, after receiving the task, the refueling operator drives the refueling vehicle to the aircraft for refueling operation. The realization of electronic, information and big data analysis technology has gradually opened up the information channel of refueling system. Based on a large number of multi-dimensional data, according to the characteristics of aircraft refueling operation, an intelligent dispatching method for aircraft refueling vehicle is provided, which can automatically assign refueling tasks, avoid flight delays and the resulting serious waste of resources and can reduce the workload of the dispatcher. Through the intelligent dispatch, refueling resources can be reasonably allocated to ensure the timely refueling of aircraft and smooth completion of flight support tasks.

Highlights ► Maternal group B streptococcus antibiotic prophylaxis (GBS-IAP) was associated with the occurrence of atopic dermatitis in 2-year-old children with vaginal delivery. ► The findings were significant in vaginal delivery before and after adjusting for multiple covariates.

Groundwater is a significant source of drinking water and a strategic resource for China. However, the groundwater quality in China is unoptimistic and China faces a severe situation regarding groundwater environment protection as its groundwater pollution prevention and control started late. Therefore, problems faced by groundwater pollution prevention and control should be researched and targeted countermeasures be proposed to curb the trend of groundwater pollution and improve groundwater quality. The study reviews the existing regulations and policies, management status, and requirements of groundwater pollution prevention and control in China, and predicts the future management trend. The results indicate the following challenges. (1) The groundwater pollution status is still unclear and hierarchical and classified management of groundwater pollution is lacking. (2) The groundwater pollution forms become increasingly complex and the regulatory system requires improvement. (3) The groundwater pollution control becomes increasingly difficult and only few control technologies were applied to underground pollution treatment. (4) The requirements of groundwater environmental management are constantly improving; however, the innovation impetus is insufficient. Therefore, we proposed several countermeasures. The pollution status should be identified through continuous investigation and assessment of groundwater environment in key regions, to support the construction of a hierarchical and classified management system. Intelligent, visualized, and coordinated supervision should be achieved by establishing a multilevel groundwater environmental monitoring network and adopting supervisory measures based on information technologies. Green and sustainable models should be formed and promoted through the experimental implementation of groundwater pollution prevention and control projects and by constructing 21 pilot sites. The original innovation and management capacities should be enhanced by focusing on key technical issues such as groundwater pollution traceability, standards system construction, and development of relevant software with proprietary intellectual property rights.

Background : The mechanism of sepsis especially non-survivors has not yet been identified. Objective : To identify the key genes concerned with non-survivor sepsis (NSS) and analyze its molecular mechanism. Methods : The original data were obtained from the GEO database to screen deferentially expressed genes (DEGs). GO and KEGG analysis were performed to analyze the functional annotation of DEGs. The protein-protein interaction (PPI) network and related analysis of hub genes were carried out. Further, hub genes were confirmed in the lipopolysaccharide (LPS)-induced septic mice by western blotting and immunohistochemistry. Results : We obtained 188 DEGs and 32 hub genes between NSS patients and healthy volunteers. Among of them, the top 10 hub genes including STAT1, ISG15, HERC1, EIF2AK2, RPL27, LY6E, IFI44L, XAF1, RSAD2 and HERC6 were studied, which predict sepsis based on receiver operator characteristic curve analysis. These hub genes were enriched in positive regulation of biomedical process including translation, response to virus and suppression of mitochondrial depolarization, etc.; cell component including mitochondrial inner membrane; molecular function containing ligase activity, etc. These hub genes are also enriched in influenza A infection and leukocyte trans-endothelial migration. The expression of these hub genes is better involved in a diagnosis of NSS, such as HERC6 (AUC = 0.9753, p = .0007), RPL27 (AUC = 0.9691, p = .0008), ISG15 (AUC = 0.9630, p = .0009), STAT1 (AUC = 0.9383, p = .0017), HERC1 (AUC = 0.9259, p = .0023), and XAF1 (AUC = 0.9259, p = .0023). Furthermore, 20 mg/kg of LPS injection up-regulated the expression of ISG15, RPL27, LY6E and HERC6 in the lung tissues compared with control mice. Conclusion : These identified 188 DEGs and 10 hub genes were associated with NSS, especially ISG15, RPL27, LY6E and HERC6 genes expressed in the lung as the most vulnerable organ.

Along with the promotion of low-carbon and zero carbon buildings such as ultra-low energy buildings, near zero energy buildings, and zero energy buildings, there is higher and higher demand to the thermal performance of building envelopes. Thermal bridges have a crucial impact on the thermal performance of building envelope structures. In order to achieve the goal of energy conservation and carbon dioxide reduction in building structures, it is necessary to conduct refined calculations and evaluations on thermal bridge treatment measures. In this paper, three thermal bridge treatment measures evaluation methods from different dimensions are presented: evaluation method based on reduction degree of thermal bridge effect, evaluation method based on carbon dioxide emissions from thermal bridges, and evaluation method based on technical economy of thermal bridges.

Objective: The purpose of this study was to mix rice and proso millets and obtain high nutritional value, fantastic taste and flavor mixed rice. Methods: By adding different proportions of proso millets to rice, the nutritional value and fantastic taste of mixed rice were evaluated via the amino acid score (AAS), texture profile properties, sensory evaluations and flavor properties. Results: There were significant differences in the texture profile properties, sensory evaluations and flavor properties among cooked proso millets additions. The proportion of the cooked rice addition was significantly positively correlated to the gumminess and chewiness of rice, while it was significant negatively related to the sensory evaluations. Furthermore, the addition of the proso millets increased the variety, content of flavor compounds in mixed rice and obviously improved the scores of the sensory evaluations. Conclusion: The integral quality and nutritional value of the mixed rice were the most excellent when the addition of the Yushu 1 proso millet was 10%~20%.

Abstract Background Arecoline is a well-known risk factor for oral submucosal fibrosis and cancer. However, the mechanistic correlation between arecoline and hepatocellular cancer remains elusive. Here, we investigated the effect of arecoline on the proliferation and migration of human HepG2 hepatoma cells and its potential oncogenic mechanisms. Methods Bioinformatic technologies were used to identify the deferentially expressed miRNAs (DE-miRNAs) and hub target genes of arecoline-induced cancers. These DE-miRNAs, hub genes and pathway were proved in arecoline-treated HepG2 cells. Results A total of 86 DE-miRNAs and 460 target genes were identified. These target genes are associated with DNA-templated regulation of transcription and other biological processes. Significant molecular functions were protein binding, calcium ion binding, and enrichment in the nucleus and cytoplasm. These genes are involved in the PI3K-AKT pathway. CDK1, CCND1, RAF1, CDKN1B and BTRC were defined as the top 5 hub target genes, and patients with high expression of CDK1 showed poor prognosis. Compared with control group, 2.5 µM arecoline treatment increased the proliferation and migration ability of the HepG2 cells. Treatment with 2.5 µM arecoline increased the levels of miR-21-3p, miR-21-5p and miR-1267, upregulated the expression of PI3K-AKT pathway factors, CDK1, CCND1 but decreased RAF1 expression. Conclusion A low concentration arecoline can induce the proliferation and migration of HepG2 cells, with the potential mechanism of action linked to high levels of exosomal miR-21 and miR-1267, activation of the PI3K-AKT pathway, upregulation of CDK1 and CCND1, and downregulation of RAF1.

Due to the large installed capacity of new energy and the shortage of peak regulation resources on the generation side, there is a serious problem of abandonment of wind and light in the new power system. To solve this problem, a spot market joint clearing mode with both sides of generation and customer participating in peak regulation is proposed in this paper. Deep peak regulation on the generation side, peak regulation with flexible load, new energy consumption and the spot market are combines in this mode, which fully explores the peak regulation capabilities on both sides of generation and customer. Firstly, a model with two parts is established in this paper. The first part is for day-ahead market and real-time market, and the other one is for both sides of generation and customer participating in peak regulation. Energy storage and power customers are regarded as customer side peak regulation resources in the model. Power customers are divided into flexible adjustment customers and non-flexible adjustment customers according to the ability to track real-time scheduling instructions. Secondly, the settlement and allocation mechanism of peak regulation auxiliary service are designed, considering the contribution and benefit degree of each market subject. Finally, the effectiveness and reasonableness for new energy consumption of the proposed market mode are verified by a calculation example. The results show that the market mode proposed in this paper reduces the amount of wind and light abandonment by 17.3% compared with the mode that only the power generation side participates in peak regulation.

Objective To investigate the prediction value of a clinical-radiomics model based on T2- weighted imaging (T2WI) and clinical features for diagnosing deep stromal invasion (DSI) in patients with early-stage cervical squamous cell carcinoma. Methods Patients with early-stage cervical squamous cell carcinoma that underwent radical hysterectomy in Peking Union Medical College Hospital from January 2017 to February 2021 were retrospectively included and randomly divided into the training set and the validation set with the the ratio of 8∶2. The preoperative clinical features and the radiomics features of sagittal T2WI images were obtained. After selection of key features, a radiomics model, a clinical model, and a clinical-radiomics model for diagnosing DSI in early-stage cervical squamous cell carcinoma were developed by Logistic regression based on the training set. The performance of different models was compared by the receiver operating characteristic (ROC) curve in the validation set. Results A total of 168 patients with early-stage cervical squamous cell carcinoma that met the inclusion and exclusion criteria were included in this study. They were randomly divided into the training set (n=135) and the validation set (n=33), in which 72 cases had histopathologically confirmed superficial stromal invasion and 96 cases had DSI. Four radiomics features and three clinical parameters (age, Federation International of Gynecology and Obstetrics stage, and preoperative squamous cell carcinoma antigen levels) were selected and used to develop models. In the validation set, the clinical-radiomics model showed better diagnostic performance with the area under the curve (AUC) of 0.820 (95% CI: 0.665-0.974) than the clinical model[AUC: 0.797(95% CI: 0.623-0.971)] and the radiomics model[AUC: 0.793(95% CI: 0.633-0.954)].The sensitivity, specificity, and accuracy of the clinical-radiomics model were 85.7%(95% CI: 49.8%-100%), 73.7%(95% CI: 57.9%-100%), and 78.8%(95% CI: 69.7%-93.9%), respectively. Conclusion Radiomics features based on T2WI images combined with clinical features can be used as a noninvasive preoperative method to determine the depth of stromal invasion in early-stage cervical squamous cell carcinoma.

Background: Acute kidney injury (AKI) is a severe clinical syndrome, and ischemia–reperfusion injury is an important cause of acute kidney injury. The aim of the present study was to investigate the related genes and pathways in the mouse model of acute kidney injury induced by ischemia–reperfusion injury (IRI-AKI).Method: Two public datasets (GSE39548 and GSE131288) originating from the NCBI Gene Expression Omnibus (GEO) database were analyzed using the R software limma package, and differentially expressed genes (DEGs) were identified. Gene Ontology (GO) and Kyoto Encyclopedia of Genomes (KEGG) and gene set enrichment analysis (GSEA) were performed using the differentially expressed genes. Furthermore, a protein-protein interaction (PPI) network was constructed to investigate hub genes, and transcription factor (TF)–hub gene and miRNA–hub gene networks were constructed. Drugs and molecular compounds that could interact with hub genes were predicted using the DGIdb.Result: A total of 323 common differentially expressed genes were identified in the renal ischemia–reperfusion injury group compared with the control group. Among these, 260 differentially expressed genes were upregulated and 66 differentially expressed genes were downregulated. Gene Ontology enrichment and Kyoto Encyclopedia of Genes and Genomes analysis results showed that these common differentially expressed genes were enriched in positive regulation of cytokine production, muscle tissue development, and other biological processes, indicating that they were involved in mitogen-activated protein kinase (MAPK), PI3K-Akt, TNF, apoptosis, and Epstein–Barr virus infection signaling pathways. Protein-protein interaction analysis showed 10 hub genes, namely, Jun, Stat3, MYC, Cdkn1a, Hif1a, FOS, Atf3, Mdm2, Egr1, and Ddit3. Using the STRUST database, starBase database, and DGIdb database, it was predicted that 34 transcription factors, 161 mi-RNAs, and 299 drugs or molecular compounds might interact with hub genes.Conclusion: Our findings may provide novel potential biomarkers and insights into the pathogenesis of ischemia–reperfusion injury–acute kidney injury through a comprehensive analysis of Gene Expression Omnibus data, which may provide a reliable basis for early diagnosis and treatment of ischemia–reperfusion injury–acute kidney injury.

The presence of multiple comorbidities in patients facing myocardial ischemia-reperfusion (IR) injury is the main obstacle for cardioprotection. This study investigated the effect of melatonin postconditioning combined with sitagliptin pretreatment on cardioprotection in diabetic aged rats by evaluating oxidative stress, apoptosis and involvement of the AMPK/SIRT1 pathway. The type-2 high-fat/streptozotocin experimental model in aged Sprague-Dawley rats (n=78) was used. The animals underwent left coronary occlusion for 30 min, followed by 3 h reperfusion. Diabetic rats were pretreated with sitagliptin (20 mg/kg, i.p.) and received melatonin (10 mg/kg, i.p.) early in reperfusion. Myocardial infarct size, histological changes, oxidative markers, mitochondrial reactive oxygen species (mitoROS) and expression of proteins regulating apoptosis and AMPK/SIRT1 activity were measured. The infarct size-sparing effect of the combination of melatonin plus sitagliptin was greater than that observed in individual treatments (P

C1q/TNF-related protein 9 (CTRP9), the closest paralog of adiponectin, has been reported to protect against inflammation-related diseases. However, its role in regulating osteoarthritis (OA) has not been fully elucidated. First, a rat model of OA was generated. Furthermore, rats with OA were injected with different doses of recombinant CTRP9 protein (rCTRP9), and the knee cartilage damage was evaluated. Finally, the phosphorylation of p38 and the secretion of matrix metalloproteinases (MMPs) were detected by Western blotting and enzyme-linked immunosorbent assay. Results revealed that CTRP9 was highly expressed in adipose tissue, followed by skeletal muscle and cartilage tissue, and less expressed in liver, kidney and lung. Moreover, the expression of CTRP9 significantly decreased in the monosodium iodoacetate (MIA) group in the knee cartilage and knee synovial fluid, and the contents of interleukin-1β (IL-1β) and IL-6 significantly increased in knee synovial fluid. In addition, rCTRP9 alleviated MIA-induced inflammation, oxidative stress and knee cartilage damage in a dose-dependent way. In addition, rCTRP9 could attenuate the expression of p38MAPK and p-p38 and suppress the expression of nuclear factor-kappa B (NF-κB), p65 and MMPs. Collectively, the results of the present study suggested that CTRP9 alleviates the inflammation of MIA-induced OA through deactivating p38MAPK and NF-κB signaling pathways in rats.

The evaluation or metrology of commercial bank management efficiency is the core of its effective management. The existing management efficiency of commercial banks adopts evaluation scheme rather than metrology. There are four shortcomings with the evaluation scheme, the evaluation is a ranking of advantages and/or disadvantages, all objects should participate in the evaluation, the evaluation results are valid only for the evaluated objects, and the evaluation results lack the metrology benchmark of the object domain. To address this issue, the paper presents a method to determine the benchmark of management efficiency, which is similar to the unit "meter" in the metrology of "length" and the unit "scale" in the metrology of "management efficiency". Firstly, the method of cluster analysis is used to solve the problem of attribute metrology base of management efficiency metrology. Based on the master of certain attribute data of commercial bank management efficiency metrology, cluster analysis is carried out onto the attribute data, and its characteristics and patterns are mined to determine the candidate benchmark set. Secondly, in the candidate datum set, k-means method is used to determine the metrology attribute datum to obtain the general metrology attributes. Finally, the absolute metrology of management efficiency is carried out for any commercial bank according to the benchmark, and the validity and feasibility of the benchmark are verified with an example. In such a way, the deficiencies of four aspects of evaluation are solved. Such a strategy can be adapted to different banks at any different time for their respective measurement, which extends the clustering statistical methods for attribute datum determination. The results can be applied to some other fields wherein object metrology is the basic task.

This article conducts numerical simulation calculations on the heat dissipation characteristics of an air-cooled radiator. The results show that under natural heat dissipation conditions, the maximum temperature of air-cooled radiators with flat heat dissipation covers decreases by 9.6% compared to radiators without heat dissipation covers, and the maximum temperature of air-cooled radiators with array raised heat dissipation covers decreases by 9.9%; Under forced air cooling conditions, the maximum temperature of an air-cooled radiator with a flat heat dissipation cover decreases by 12.7%, while the maximum temperature of an air-cooled radiator with an array raised heat dissipation cover decreases by 13.3%.

Ventilator-induced lung injury (VILI) is one of the most common complications of mechanical ventilation and can severely affect health. VILI appears to involve excessive inflammatory responses, but its pathogenesis has not yet been clarified. Since interleukin-17 (IL-17) plays a critical role in the immune system and the development of infectious and inflammatory diseases, we investigated here whether it plays a role in VILI. In a mouse model of VILI, mechanical ventilation with high tidal volume promoted the accumulation of lung neutrophils, leading to increased IL-17 levels in the lung, which in turn upregulated macrophage chemoattractant protein-1 via p38 mitogen-activated protein kinase. Depletion of neutrophils decreases the production IL-17 in mice and inhibition of IL-17 significantly reduced HTV-induced lung injury and inflammatory response. These results were confirmed in vitro using RAW264.7 macrophage cultures. Our results suggest that IL-17 plays a pro-inflammatory role in VILI and could serve as a new target for its treatment.

BackgroundIn animal models of ventilation-induced lung injury, mitophagy triggers mitochondria damage and the release of mitochondrial (mt) DNA, which activates inflammation. However, the mechanism of this process is unclear.MethodsA model of cyclic stretching (CS)-induced lung epithelial cell injury was established. The genetic intervention of phosphatase and tensin homolog-induced kinase 1 (PINK1) expression via lentivirus transfection was used to identify the relationship between PINK1-mediated mitophagy and mtDNA release in stretching-induced inflammatory response and injury. Pharmacological inhabitation of Toll-like receptor 9 (TLR9) and myeloid differentiation factor 88 (MyD88) expression was performed via their related inhibitors, while pre-treatment of exogenous mtDNA was used to verify the role of mtDNA in stretching-induced inflammatory response and injury.ResultsUsing a cell culture model of CS, we found that knocking down PINK1 in lung epithelial cells reduced mitophagy activation and mtDNA release, leading to milder inflammatory response and injury; conversely, up-regulating PINK1 exacerbated stretching-induced inflammation and injury, and similar effects were observed by upregulating TLR9 to induce expression of MyD88 and nuclear factor-κB (NF-κB)/p65. Down-regulating MyD88 protected lung epithelial cells from stretching injury and decreased NF-κB/p65 expression.ConclusionThese findings suggest that PINK1-dependent mitophagy and associated TLR9 activation is indeed a major factor in stretch-induced cell injury via a mechanism in which released mtDNA activates TLR9 and thereby the MyD88/NF-κB pathway. Inhibiting this process may be a therapeutic approach to prevent inflammation and cell injury in patients on mechanical ventilation.

Anemia in the elderly may impair cognitive function. Our primary objective was to determine whether cancer-related anemia was associated with postoperative cognitive dysfunction (POCD) in nonelderly patients. We conducted an observational prospective study of 177 patients scheduled for laparoscopic surgery. Patients aged 18-64 were divided into two groups according to whether they were anemic due to cancer or not. The cognitive function was assessed by the Mini-Mental State Examination (MMSE) 1 day before and 1 week after operation. The cognitive function of the patients was evaluated by using the Telephone Interview for Cognitive Status-Modified (TICS-M) 3 months after operation. The quality of life of patients was evaluated after operation. The hemoglobin level and other clinical data were recorded before operation. Of the 170 patients, 100 without anemia and 70 anemia patients had been evaluated 1 week after operation. POCD was detected in 43 cases (25.3% of 170 cases) at 1 week and 30 cases (19% of 158 cases) at 3 months postoperatively. Anemia was an independent risk factor for 3-month POCD occurrence (P=0.034). The education level of the patients who had POCD at 1 week and 3 months after operation was lower (P

The combined radiant floor and fan coil cooling (RFCAFC) system is widely used due to its high comfort and large energy saving potential. In this study, as an example, the combined RFCAFC system was studied in a high humidity environment in Jinan, Shandong Province, China. Days with similar outdoor meteorological conditions were grouped, and the comfort level and other evaluation indicators. The RFCAFC had good energy efficiency and comfort when the room was in a high humidity environment. This study showed that the radiant floor surface temperature uniformity coefficient (S) fluctuated between 0.7 and 1.0. The proportion of the total cooling capacity contributed by fan coil cooling under low temperature and high humidity (LH) is 68.0%. The combined cooling system used the LH operating strategy, the PMV value fluctuated from 0.12 to 0.49. Based on this study, the following recommendations for the combined cooling system can be made: (1) When the outdoor humidity is high, the radiant floor system should be turned on early to provide cooling capacity. (2) The operation strategy of the combined cooling system must be able to respond in real time to changes in outdoor meteorological conditions to prevent discomfort in times of extreme heat or humidity.

Radiant cooling systems have good application prospects. A variety of composite radiative cooling systems have been proposed to save energy, but few studies have focused on comparing the performance of different radiant floor cooling systems. This study compares the cooling performance operating conditions of a floor radiant system with direct ground cooling and conventional radiant cooling systems. In addition to the comfort conditions required by the standard, Jinan, Shandong also studied the low risk of condensation on the floor surface. At the same time, the energy consumption of different radiative cooling systems is compared and the potential of the system is analyzed. Preliminary results found a 26% reduction in energy consumption for system operation compared to conventional radiant cooling systems. Although the radiant floor system using the ground direct cooling system does not reduce energy consumption when the water tank is turned on for energy storage at night, the electricity cost is reduced due to the peak and valley electricity price at night. The research will provide architects and engineers with more efficient and energy-efficient technologies that reduce carbon emission.

In situ produced 10Be and 26Al in fluvial terrace samples that have been repeatedly buried and exposed to the evolution process are difficult to separate using conventional methods. Based on prior experiments, 10Be in carbonate, iron-bearing mineral and 10Be produced in the atmosphere were separated by manual hand picking, magnetic separator sorting and acid washing methods, improving the procedure of purifying the quartz samples. The results show that anion exchange column, with a length of 9 cm and inner diameter of 1cm, matched 4 mol/L hydrofluoric acid leachate, can effectively separate B, Mg, Ca, Cr, Fe, Mn, Ni, Ti and Mn. The recoveries of Be and Al are 95.7% and 85.7%, resepectively. Be and Al can be separated by ion exchange very well which have recoveries up to 85%. The procedure blanks are 2.19×10-15 and 1.63×10-15 for 10Be/9Be and 26Al/27Al, respectively which are comparable with other labs. The exposure ages of Chengdu Plain alluvial elements are 76.36±9.51 ka for 10Be and 69.44±14.13 ka for 26Al, which provides a chronological basis for evaluating the structural features and activities of buried faults in the front of the Longmenshan.

INTRODUCTION:Non-intubated anesthesia (NIA) has been proposed for video-assisted thoracoscopic surgery (VATS), although how the benefit-to-risk of NIA compares to that of intubated general anesthesia (IGA) for certain types of patients remains unclear. Therefore, the aim of the present meta-analysis was to understand whether NIA or IGA may be more beneficial for patients undergoing VATS. METHODS:A systematic search of Cochrane Library, Pubmed and Embase databases from 1968 to April 2019 was performed using predefined criteria. Studies comparing the effects of NIA or IGA for adult VATS patients were considered. The primary outcome measure was hospital stay. Pooled data were meta-analyzed using a random-effects model to determine the standard mean difference (SMD) with 95% confidence intervals (CI). RESULTS AND DISCUSSION:Twenty-eight studies with 2929 patients were included. The median age of participants was 56.8 years (range 21.9-76.4) and 1802 (61.5%) were male. Compared to IGA, NIA was associated with shorter hospital stay (SMD -0.57 days, 95%CI -0.78 to -0.36), lower estimated cost for hospitalization (SMD -2.83 US, 95% CI -4.33 to -1.34), shorter chest tube duration (SMD -0.32 days, 95% CI -0.47 to -0.17), and shorter postoperative fasting time (SMD, -2.76 days; 95% CI -2.98 to -2.54). NIA patients showed higher levels of total lymphocytes and natural killer cells and higher T helper/T suppressor cell ratio, but lower levels of interleukin (IL)-6, IL-8 and C-reactive protein (CRP). Moreover, NIA patients showed lower levels of fibrinogen, cortisol, procalcitonin and epinephrine. CONCLUSIONS:NIA enhances the recovery from VATS through attenuation of stress and inflammatory responses and stimulation of cellular immune function.