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434 results on '"ROGERS, MARC A."'

2. Supporting and Motivating Re-integration of Justice-Involved Individuals Through Dynamic Gamification

Author

Diliberti, Nicholas, Chung, Haeyong, Keim, Yansi, Rogers, Marc, Karabiyik, Umit, Aggarwal, Sudhir, Mukherjee, Tathagata, Pettus, Carrie, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Kurosu, Masaaki, editor, and Hashizume, Ayako, editor

Published
2023
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7. Prostatic irradiation-induced sexual dysfunction: a review and multidisciplinary guide to management in the radical radiotherapy era (Part I defining the organ at risk for sexual toxicities)

Author

Ramirez-Fort, Marigdalia K., Rogers, Marc J., Santiago, Roberto, Mahase, Sean S., Mendez, Melissa, Zheng, Yi, Kong, Xiang, Kashanian, James A., Niaz, M. Junaid, McClelland, Shearwood, III, Wu, Xiaodong, Bander, Neil H., Schlegel, Peter, Mulhall, John P., and Lange, Christopher S.

Published
2020
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8. A systematic strategy for estimating hERG block potency and its implications in a new cardiac safety paradigm

Author

Ridder, Bradley J., Leishman, Derek J., Bridgland-Taylor, Matthew, Samieegohar, Mohammadreza, Han, Xiaomei, Wu, Wendy W., Randolph, Aaron, Tran, Phu, Sheng, Jiansong, Danker, Timm, Lindqvist, Anders, Konrad, Daniel, Hebeisen, Simon, Polonchuk, Liudmila, Gissinger, Evgenia, Renganathan, Muthukrishnan, Koci, Bryan, Wei, Haiyang, Fan, Jingsong, Levesque, Paul, Kwagh, Jae, Imredy, John, Zhai, Jin, Rogers, Marc, Humphries, Edward, Kirby, Robert, Stoelzle-Feix, Sonja, Brinkwirth, Nina, Rotordam, Maria Giustina, Becker, Nadine, Friis, Søren, Rapedius, Markus, Goetze, Tom A., Strassmaier, Tim, Okeyo, George, Kramer, James, Kuryshev, Yuri, Wu, Caiyun, Himmel, Herbert, Mirams, Gary R., Strauss, David G., Bardenet, Rémi, and Li, Zhihua

Published
2020
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10. Using automated patch clamp electrophysiology platforms in ion channel drug discovery: an industry perspective

Author

Rogers, Marc, Obergrussberger, Alison, Kondratskyi, Artem, and Fertig, Niels

Abstract

ABSTRACTIntroductionAutomated patch clamp (APC) is now well established as a mature technology for ion channel drug discovery in academia, biotech and pharma companies, and in contract research organizations (CRO), for a variety of applications including channelopathy research, compound screening, target validation and cardiac safety testing.Areas coveredIon channels are an important class of drugged and approved drug targets. The authors present a review of the current state of ion channel drug discovery along with new and exciting developments in ion channel research involving APC. This includes topics such as native and iPSC-derived cells in ion channel drug discovery, channelopathy research, organellar and biologics in ion channel drug discovery.Expert opinionIt is our belief that APC will continue to play a critical role in ion channel drug discovery, not only in ‘classical’ hit screening, target validation and cardiac safety testing, but extending these applications to include high throughput organellar recordings and optogenetics. In this way, with advancements in APC capabilities and applications, together with high resolution cryo-EM structures, ion channel drug discovery will be re-invigorated, leading to a growing list of ion channel ligands in clinical development.

Published
2024
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13. The role of Nav1.7 in human nociceptors: insights from human induced pluripotent stem cell–derived sensory neurons of erythromelalgia patients

Author

Meents, Jannis E., Bressan, Elisangela, Sontag, Stephanie, Foerster, Alec, Hautvast, Petra, Rösseler, Corinna, Hampl, Martin, Schüler, Herdit, Goetzke, Roman, Le, Thi Kim Chi, Kleggetveit, Inge Petter, Le Cann, Kim, Kerth, Clara, Rush, Anthony M., Rogers, Marc, Kohl, Zacharias, Schmelz, Martin, Wagner, Wolfgang, Jørum, Ellen, Namer, Barbara, Winner, Beate, Zenke, Martin, and Lampert, Angelika

Published
2019
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14. Editorial: Targeting ion channels for drug discovery: emerging challenges for high throughput screening technologies.

Author

Hernandez, Ciria C., Gimenez, Luis E., Strassmaier, Tim, Rogers, Marc, and Taymans, Jean-Marc

Subjects
HIGH throughput screening (Drug development), DRUG discovery, ION channels, ACID-sensing ion channels, LIGAND-gated ion channels, CALCIUM ions, SUMATRIPTAN
Abstract

This editorial titled "Targeting ion channels for drug discovery: emerging challenges for high throughput screening technologies" discusses the importance of ion channels as drug targets and the challenges associated with developing drugs that modulate ion channels. It highlights advancements in high throughput screening technologies for studying ion channels and showcases cutting-edge research in this field. The document also mentions specific studies that focus on optimizing automated patch clamp and optogenetic screening platforms for studying ion channel activity and modulation. The document summarizes a collection of articles on ion channels as drug targets, covering various topics such as the development of new technologies for optogenetic assays, the application of high-throughput electrophysiological profiling in personalized medicine, the direct effects of cannabinoids on ion channels, and the potential for blocking specific ion channels to treat migraines. It also discusses the use of CRISPR technology to modulate gene expression and the analysis of ion channel mutations linked to epileptic encephalopathies. The articles provide insights into novel approaches for drug screening and strategies to improve ion channel drug targeting. [Extracted from the article]

Published
2024
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23. An examination of predictive markers for successful sperm extraction procedures: a linear model and systematic review.

Author

Major, Nicholas, Edwards, K, Simpson, Kit, and Rogers, Marc

Abstract

The authors performed a comprehensive review of current literature to create a model comparing commonly evaluated variables in male factor infertility, for example, follicle-stimulating hormone (FSH), testicular volume (TV), and testosterone (T), to better predict sperm retrieval rate (SRR). Twenty-nine studies were included, 9 with data on conventional testicular sperm extraction (cTESE) for a total of 1227 patients and 20 studies including data on microdissection testicular sperm extraction (mTESE) for a total of 4760 patients. A weighted-means value of SRR, FSH, T, and TV was created, and a weighted linear regression was then used to describe associations among SRR, type of procedure, FSH, T, and TV. In this study, weighted-means values demonstrated mTESE to be superior to cTESE with an SRR of 51.9% vs 40.1%. Multiple weighted linear regressions were created to describe associations among SRR, procedure type, FSH, T, and TV. The models showed that for every 1.19 mIU ml−1 increase in FSH, there would be a significant decrease in SRR by 1.0%. Seeking to create a more clinically relevant model, FSH values were then divided into normal, moderate elevation, and significant elevation categories (FSH <10 mIU ml−1, 10–19 mIU ml−1, and >20 mIU ml−1, respectively). For an index patient undergoing cTESE, the retrieval rates would be 57.1%, 44.3%, and 31.2% for values normal, moderately elevated, and significantly elevated, respectively. In conclusion, in a large meta-analysis, mTESE was shown to be more successful than cTESE for sperm retrievals. FSH has an inverse relationship to SRR in retrieval techniques and can alone be predictive of cTESE SRR. [ABSTRACT FROM AUTHOR]

Published
2023
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24. Lesbian, gay, and bisexual voters in the 2000 U.S. presidential election

Author

Lewis, Gregory B., Rogers, Marc A., and Sherrill, Kenneth

Subjects
Americans -- Political activity -- Demographic aspects, Presidents -- Elections, Gays -- Political activity, Voting -- Social aspects, Political science, Democratic Party (United States) -- Public opinion
Abstract

Lesbians, gay men, and bisexuals (LGBs) in the United States are strikingly more likely to vote for Democratic presidential candidates than heterosexuals. LGBs are one of the Democratic Party's most loyal voting blocs, despite the absence of one of the most important mechanisms for creating party identification: intergenerational transmission. We use the 2000 Presidential election to examine whether LGB voters overwhelmingly chose Al Gore because they viewed him as superior to George W. Bush on LGB-related policy issues or because of their greater overall liberalism and Democratic Party identification. We also examine the impact of socialization within the LGB community for generating political liberalism, Democratic Party identification, and interest in LGB policies. Using logit analysis on a 2000 Harris Interactive poll of 13,000 Americans, including 1,000 LGBs, we find that concern for LGB rights, policy liberalism, and party identification all played a role in the LGB vote. Keywords: Voting Behavior, Public Opinion, Parties, Elections, LGBT, Political Issues, Political Ideology. Lesbianas, hombres gay y bisexuales (LGB) en los Estados Unidos son mucho mas propensos a por votar candidatos presidenciales Democraticos que personas heterosexuales. Los LGB son uno de los grupos electoral mas leal del Partido Democratico, a pesar de la ausencia de uno de los mecanismos mas importantes para crear identificacion partidista: la transmision intergeneracional. En este articulo usamos la eleccion presidencial del 2000 para examinar si los electores LGB eligieron a Al Gore porque lo consideraban superior a George W. Bush en politicas relacionadas con asuntos LGB o debido a su mayor liberalismo e identificacion con el Partido Democratico. Tambien examinamos el impacto de la socializacion dentro de la comunidad LGB para generar liberalismo politico, identificacion con el Partido Democratico, e interes en politicas relacionadas con asuntos LGB. Usando un analisis logit en una encuesta interactiva Harris 2000 de 13,000 estadounidenses, incluyendo 1,000 LGB, los resultados muestran que interes por derechos para los LGB, liberalismo politico, e identificacion partidaria juegan un papel importante en el voto LGB., Lesbian, gay, and bisexual (LGB) (1) voters in the United States have given two-thirds or more of their votes to Democratic presidential candidates at least since 1988 (Bailey 2000; Egan [...]

Published
2011

28. Corrigendum to “A systematic strategy for estimating hERG block potency and its implications in a new cardiac safety paradigm” [Toxicology and Applied Pharmacology volume 394C (2020) 114961]

Author

Ridder, Bradley J., Leishman, Derek J., Bridgland-Taylor, Matthew, Samieegohar, Mohammadreza, Han, Xiaomei, Wu, Wendy W., Randolph, Aaron, Tran, Phu, Sheng, Jiansong, Danker, Timm, Lindqvist, Anders, Konrad, Daniel, Hebeisen, Simon, Polonchuk, Liudmila, Gissinger, Evgenia, Renganathan, Muthukrishnan, Koci, Bryan, Wei, Haiyang, Fan, Jingsong, Levesque, Paul, Kwagh, Jae, Imredy, John, Zhai, Jin, Rogers, Marc, Humphries, Edward, Kirby, Robert, Stoelzle-Feix, Sonja, Brinkwirth, Nina, Rotordam, Maria Giustina, Becker, Nadine, Friis, Søren, Rapedius, Markus, Goetze, Tom A., Strassmaier, Tim, Okeyo, George, Kramer, James, Kuryshev, Yuri, Wu, Caiyun, Himmel, Herbert, Mirams, Gary R., Strauss, David G., Bardenet, Remi, and Li, Zhihua

Published
2020
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32. Protestant Christendom

Author

White, Heath, Mohler, Jr., R. Albert, Colson, Charles, Rogers, Marc, Doerr, Edd, Schenk, Don, Rottenberg, Isaac C., Jenson, Robert W., Biezad, Daniel J., Reeves, Bill, Nieli, D. Bruce, Niblack, Philip, Ingraham, Barton L., and Bottum, Joseph

Subjects
Philosophy and religion
Abstract

Joseph Bottum's article, 'The Death of Protestant America: A Political Theory of the Protestant Mainline' (August/September 2008) is, as usual, a tour de force. He rightly notes that the Mainline [...]

Published
2008

42. Identification of an operon required for ferrichrome iron utilization in Vibrio cholerae

Author

Rogers, Marc B., Sexton, Jessica A., DeCastro, G. Joel, and Calderwood, Stephen B.

Subjects
Operons -- Genetic aspects, Iron -- Physiological aspects, Vibrio cholerae -- Genetic aspects, Biological sciences
Abstract

Research describes identification, mapping and amino acid sequencing of an operon involved in the ferrichrome iron utilization in Vibrio cholerae.

Published
2000

45. Europeans in the USA: Easing (defence trade) traffic on the two-way street

Author

Rogers, Marc

Subjects
ARMS INDUSTRY AND TRADE - North Atlantic Treaty Organization, DEFENSE INDUSTRY AND TRADE - North Atlantic Treaty Organization, WEAPONS PROCUREMENT - North Atlantic Treaty Organization, NORTH ATLANTIC TREATY ORGANIZATION - Equipment, EQUIPMENT - North Atlantic Treaty Organization
Abstract

illus por chart

Published
1991

46. Will NATO go global?

Author

Rogers, Marc

Subjects
NORTH ATLANTIC TREATY ORGANIZATION, TREATIES AND ALLIANCES, SECURITY, INTERNATIONAL, PARTNERSHIP FOR PEACE, UNITED STATES - Foreign Relations - France
Abstract

illus por

Published
1999

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