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3. Circulating leptin is associated with serum uric acid level and its tubular reabsorption in a sample of adult middle-aged men

Author

D’Elia, L., Giaquinto, A., Cappuccio, F. P., Iacone, R., Russo, O., Strazzullo, P., and Galletti, F.

Abstract

Purpose: Leptin is associated with cardiovascular risk factors (e.g. hypertension, insulin resistance, kidney disease and excess body weight). Experimental studies showed that leptin might affect serum uric acid, by modulation of the uric acid excretion. However, there are few observational data on the relationship between leptin and uric acid in the general population. Therefore, the aim of the present study was to evaluate the relationship between leptin and uric acid and its excretion in a large middle-aged male general population. Methods: A sample of 930 adult male individuals (mean age: 52 years) without therapy for high uric acid was included in the analysis (the Olivetti Heart Study). Results: Uric acid was significantly and positively associated with blood pressure, BMI, waist circumference, insulin resistance, C-reactive protein and leptin (p?<?0.01), while inversely with renal function (p?=?0.01). The multivariate analysis confirmed the association between leptin and uric acid after adjustment for potential confounders (p?<?0.01). After division for adiposity, this trend was confirmed separately for normal weight and excess body weight participants. Moreover, leptin was inversely associated with excretion of uric acid (p?<?0.01), also in multivariate analysis (p?=?0.03). Conclusion: The results of this study indicate a positive association between circulating leptin levels and uric acid, independently of potential confounders, both in normal and excess body weight men. Furthermore, an inverse association between leptin and uric acid excretion was detected.

Published
2024
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6. Relationship between salt consumption and iodine intake in a pediatric population

Author

Iacone, R., Iaccarino Idelson, P., Campanozzi, A., Rutigliano, I., Russo, O., Formisano, P., Galeone, D., Macchia, P. E., Strazzullo, P., Agabiti-Rosei, E., Carcea, M., Donfrancesco, C., Galletti, F., Giampaoli, S., Iacoviello, L., Scalfi, L., Siani, A., De Filippo, G., Malamisura, B., Cecere, G., Micillo, M., D'Angelo, E., Maschione, R., De Marco, G., D'Angelo, G., Cosenza, C., Gualano, R., Borsetti, R., Cela, G., Francavilla, R., Tetro, A., Pensabene, L., Talarico, V., Graziano, F., Palermo, B. V. E., Lombardi, G., Illiceto, M. T., Tonelli, L., Catassi, C., Tonelli, G., Castellucci, G., Ferraro, L., Cozzali, R., Di Biase, R., Cipolli, S., Lezo, A., Santini, B., Salvatore, S., Morando, L., Paoletti, S., Gallese, A., Mazzone, T., Iacone, Roberto, IACCARINO IDELSON, Paola, Campanozzi, Angelo, Rutigliano, Irene, Russo, Ornella, Formisano, Pietro, Galeone, Daniela, Macchia, PAOLO EMIDIO, and Strazzullo, Pasquale

Subjects
Adolescent, Endocrinology, Diabetes and Metabolism, Salt (chemistry), Nutritional Status, Medicine (miscellaneous), Context (language use), Sodium Chloride, World health, Animal science, 24 h urinary excretion, Environmental health, salt, Humans, Medicine, Sodium Chloride, Dietary, Salt intake, Child, Iodine intake, chemistry.chemical_classification, Thyroid, Consumption (economics), Nutrition and Dietetics, iodine prophylaxi, business.industry, Salt reduction, Iodine deficiency disorders, Original Contribution, Iodised salt, pediatric, chemistry, Italy, iodine deficiency disorder, Salt restriction, Hypertension, Iodine prophylaxis, Cardiology and Cardiovascular Medicine, business, Pediatric age, Iodine, Pediatric population
Abstract

Purpose The World Health Organization recommends reduction of salt intake to Methods The study population was made of 1270 children and adolescents. Estimates of salt consumption and iodine intake were obtained by measuring 24 h urinary sodium and iodine excretion. Results The iodine intake increased gradually across quartiles of salt consumption independently of sex, age and body weight (p 10.2 g/day). We estimated that approximately 65–73% of the total iodine intake was derived from food and 27–35% from iodized salt and that iodized salt made actually only 20% of the total salt intake. Conclusion In this pediatric population, in face of an elevated average salt consumption, the use of iodized salt was still insufficient to ensure an adequate iodine intake, in particular among teenagers. In the perspective of a progressive reduction of total salt intake, the health institutions should continue to support iodoprophylaxis, in the context of the national strategies for salt reduction. In order for these policies to be successful, in addition to educational campaigns, it is needed that the prescriptions contained in the current legislation on iodoprophylaxis are made compelling through specific enforcement measures for all the involved stakeholders.

Published
2020
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28. Aliment…..azione e Salute

Author

TRIASSI, MARIA, FABBROCINI, GABRIELLA, MONTUORI, PAOLO, AYALA, FABIO, RUSSO I, PAGANO A, MAINADI P, SCHERILLO I, VAIRANO MP, TROIANO E, RESCIGNO O, RUSSO O, Triassi, Maria, Fabbrocini, Gabriella, Montuori, Paolo, Russo, I, Pagano, A, Mainadi, P, Scherillo, I, Vairano, Mp, Troiano, E, Rescigno, O, Russo, O, and Ayala, Fabio

Subjects
Salute, Alimentazione
Abstract

Descrive le modalità di prevenzione delle malattie associate all'alimentazione

Published
2005

30. Valori normali di FT3, FT4 e TSH nei bambini sani

Author

CIOFFI, Michele, Pilla P, Russo O, VIETRI, Maria Teresa, Mazzeo A, Di Troia D, Sica V, MOLINARI, Anna Maria, Cioffi, Michele, Pilla, P, Russo, O, Vietri, Maria Teresa, Mazzeo, A, Di Troia, D, Sica, V, and Molinari, Anna Maria

Published
2002

32. Dosaggio della cromogranina A nel carcinoma del polmone

Author

CIOFFI, Michele, VIETRI, Maria Teresa, Pilla P, Porcelli C, Mazzeo A, Guarino A, Russo O, Sica V, MOLINARI, Anna Maria, Cioffi, Michele, Vietri, Maria Teresa, Pilla, P, Porcelli, C, Mazzeo, A, Guarino, A, Russo, O, Sica, V, and Molinari, Anna Maria

Published
2002

36. Associations of selenium status with cardiometabolic risk factors: An 8-year follow-up analysis of the Olivetti Heart Study

Author

Stranges S, Galletti F, Farinaro E, D'Elia L, Russo O, Iacone R, Capasso C, Carginale V, De Luca V, Della Valle E, Cappuccio FP, and Strazzullo P

Abstract

OBJECTIVE: High selenium status has been associated with adverse cardiometabolic outcomes in selenium-replete populations such as the US. In populations with lower selenium status such as in Italy, there is little epidemiological evidence about the association of selenium with cardiometabolic risk factors. We therefore examined cross-sectional and prospective relationships of serum selenium concentrations with cardiometabolic risk factors including blood pressure, diabetes and blood lipids in the Olivetti Heart Study. METHODS: The study population consisted of 445 adult male individuals for whom baseline serum selenium measurement and cardiometabolic risk factors at baseline (1994-1995) and follow-up examination (2002-2004: average follow-up=8 years) were available. Serum selenium was measured by atomic absorption spectrophotometry. RESULTS: Average serum selenium concentration at baseline was 77.5±18.4¼g/L. In cross-sectional analyses, serum selenium levels were positively associated with serum total cholesterol (p for trend

Published
2011

38. PP.02.33

Author

D’Elia, L., primary, Iannotta, C., additional, Sabino, P., additional, Rossi, G., additional, Di Cola, M. Schiano, additional, Savino, I., additional, Russo, O., additional, Iacone, R., additional, Palmieri, L., additional, Giampaoli, S., additional, Galletti, F., additional, and Strazzullo, P., additional

Published
2015
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44. High circulating leptin levels are associated with greater risk of hypertension in men independently of body mass and insulin resistance: results of an 8-year follow-up study

Author

Galletti F, D'Elia L, Barba G, Siani A, Cappuccio FP, Farinaro E, Iacone R, Russo O, De Palma D, Ippolito R, and Strazzullo P.

Subjects
hypertension, leptin, body mass
Abstract

BACKGROUND: We previously reported a significant association between plasma leptin (LPT) concentration and blood pressure (BP), which was partly independent of serum insulin levels and insulin resistance. The aims of this study were to detect whether serum LPT levels predict the development of hypertension (HPT) in the 8-yr follow-up investigation of a sample of an adult male population (the Olivetti Heart Study), and to evaluate the role of body mass index (BMI) and insulin resistance in this putative association. PATIENTS AND METHODS: The study population was made up of 489 untreated normotensive subjects examined in 1994-1995 (age: 50.1 +/- 6.7 yr; BMI: 26.3 +/- 2.8 kg/m(2); BP: 120 +/- 10/78 +/- 6 mm Hg; and homeostatic model assessment index: 2.1 +/- 1.6). RESULTS: The HPT incidence over 8 yr was 35%. The participants with incident HPT had similar age but higher BMI (P < 0.001), serum LPT (P < 0.001), and BP (P < 0.01) at baseline. One sd positive difference in baseline serum LPT log was associated at univariate analysis with a 49% higher rate of HPT [95% confidence interval (CI) 22-83; P < 0.001]). In three different models of multivariable logistical regression analysis, LPT was respectively associated with a 41% greater risk to develop HPT (95% CI 15-74; P < 0.001) upon adjustment for age and baseline BP, with a 48% (95% CI 20-81) greater risk when adding the homeostatic assessment model index to the model, and with 33% greater risk (95% CI 6-67; P < 0.02) upon adjustment for BMI. CONCLUSIONS: In this sample of originally normotensive men, circulating LPT level was a significant predictor of the risk to develop HPT over 8 yr, independently of BMI and insulin resistance.

Published
2008
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