1. Absence of Cerebrospinal Fluid Signs of Neuronal Injury Before and After Immediate Antiretroviral Therapy in Acute HIV Infection
- Author
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Peluso, Michael J, Valcour, Victor, Ananworanich, Jintanat, Sithinamsuwan, Pasiri, Chalermchai, Thep, Fletcher, James LK, Lerdlum, Sukalya, Chomchey, Nitiya, Slike, Bonnie, Sailasuta, Napapon, Gisslén, Magnus, Zetterberg, Henrik, Spudich, Serena, and RV254/SEARCH 010 and SEARCH 011 Study Teams
- Subjects
Adult ,Male ,antiretroviral therapy ,HIV Infections ,Neuroimaging ,Medical and Health Sciences ,Microbiology ,neuroinflammation ,Cohort Studies ,Young Adult ,Neurofilament Proteins ,Clinical Research ,Humans ,RV254/SEARCH 010 and SEARCH 011 Study Teams ,Neurosciences ,Biological Sciences ,Magnetic Resonance Imaging ,magnetic resonance spectroscopy ,neurological injury ,neurofilament light chain ,Infectious Diseases ,Good Health and Well Being ,Anti-Retroviral Agents ,HIV/AIDS ,Female ,Infection - Abstract
BackgroundIt is unknown whether neuronal injury begins during acute human immunodeficiency virus (HIV) infection, and whether immediate initiation of combination antiretroviral therapy (cART) prevents neuronal injury.MethodsCerebrospinal fluid (CSF) neurofilament light chain (NFL), a measure of axonal injury, was assessed before and after cART initiation in individuals starting treatment during acute or chronic HIV infection. Nonparametric statistics examined relationships between NFL and disease progression, neuroinflammation, and cognitive performance.ResultsBefore treatment, subjects with acute infection had lower CSF NFL levels, with elevations for their age in 1 of 32 subjects with acute infection (3.1%) and 10 of 32 with chronic infection (31%) (P = .006). This persisted after cART initiation, with 1 of 25 acute (4%) and 4 of 9 chronic subjects (44%) showing elevated NFL levels (P = .01). In acute infection, pre-cART NFL levels were inversely correlated with proton magnetic resonance spectroscopic findings of N-acetylaspartate/creatine in frontal gray matter (r = -0.40; P = .03), frontal white matter (r = -0.46; P = .01), and parietal gray matter (r = -0.47; P = .01); correlations persisted after treatment in the frontal white matter (r = -0.51; P = .02) and parietal gray matter (r = -0.46; P = .04).ConclusionsCSF NFL levels are not elevated in untreated acute HIV infection or after 6 months of immediately initiated cART but are abnormal in chronic HIV infection before and after treatment. In acute HIV infection, CSF NFL levels are inversely associated with neuroimaging markers of neuronal health.
- Published
- 2015