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2. Biomarkers for Adjuvant Endocrine and Chemotherapy in Early-Stage Breast Cancer: ASCO Guideline Update

Author

Andre, Fabrice, primary, Ismaila, Nofisat, additional, Allison, Kimberly H., additional, Barlow, William E., additional, Collyar, Deborah E., additional, Damodaran, Senthil, additional, Henry, N. Lynn, additional, Jhaveri, Komal, additional, Kalinsky, Kevin, additional, Kuderer, Nicole M., additional, Litvak, Anya, additional, Mayer, Erica L., additional, Pusztai, Lajos, additional, Raab, Rachel, additional, Wolff, Antonio C., additional, and Stearns, Vered, additional

Published
2022
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3. In vivo assessment of the metabolic activity of CYP2D6 diplotypes and alleles

Author

Hertz, Daniel L., Snavely, Anna C., McLeod, Howard L., Walko, Christine M., Ibrahim, Joseph G., Anderson, Steven, Weck, Karen E., Magrinat, Gustav, Olajide, Oludamilola, Moore, Susan, Raab, Rachel, Carrizosa, Daniel R., Corso, Steven, Schwartz, Garry, Peppercorn, Jeffrey M., Evans, James P., Jones, David R., Desta, Zeruesenay, Flockhart, David A., Carey, Lisa A., and Irvin, William J., Jr

Published
2015
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6. Implementing a personalized medicine cancer program in a community cancer system

Author

Dressler, Lynn G, primary, Bell, Gillian C, additional, Schuetze, David P, additional, Steciuk, Mark R, additional, Binns, Oliver A, additional, Raab, Rachel E, additional, Abernathy, Pearl M, additional, Wilson, Carolyn M, additional, Kunutsor, Sedope E, additional, Loveless, Marika C, additional, Ahearne, Paul M, additional, and Messino, Michael J, additional

Published
2019
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7. In vivo assessment of the metabolic activity of CYP2D6 diplotypes and alleles

Author

Hertz, Daniel L, Snavely, Anna C, McLeod, Howard L, Walko, Christine M, Ibrahim, Joseph G, Anderson, Steven, Weck, Karen E, Magrinat, Gustav, Olajide, Oludamilola, Moore, Susan, Raab, Rachel, Carrizosa, Daniel R, Corso, Steven, Schwartz, Garry, Peppercorn, Jeffrey M, Evans, James P, Jones, David R, Desta, Zeruesenay, Flockhart, David A, Carey, Lisa A, and Irvin, William J

Subjects
Adult, Aged, 80 and over, Antineoplastic Agents, Hormonal, Genotype, Middle Aged, digestive system, Tamoxifen, Young Adult, Phenotype, Cytochrome P-450 CYP2D6, Pharmacogenetics, Humans, Female, skin and connective tissue diseases, Alleles, Genetic Association Studies, Aged
Abstract

A prospectively enrolled patient cohort was used to assess whether the prediction of CYP2D6 phenotype activity from genotype data could be improved by reclassification of diplotypes or alleles.Three hundred and fifty-five patients receiving tamoxifen 20 mg were genotyped for CYP2D6 and tamoxifen metabolite concentrations were measured. The endoxifen : N-desmethly-tamoxifen metabolic ratio, as a surrogate of CYP2D6 activity, was compared across four diplotypes (EM/IM, EM/PM, IM/IM, IM/PM) that are typically collapsed into an intermediate metabolizer (IM) phenotype. The relative metabolic activity of each allele type (UM, EM, IM, and PM) and each EM and IM allele was estimated for comparison with the activity scores typically assigned, 2, 1, 0.5 and 0, respectively.Each of the four IM diplotypes have distinct CYP2D6 activity from each other and from the EM and PM phenotype groups (each P 0.05). Setting the activity of an EM allele at 1.0, the relative activities of a UM, IM and PM allele were 0.85, 0.67 and 0.52, respectively. The activity of the EM alleles were statistically different (P 0.0001), with the CYP2D6*2 allele (scaled activity = 0.63) closer in activity to an IM than an EM allele. The activity of the IM alleles were also statistically different (P = 0.014).The current systems for translating CYP2D6 genotype into phenotype are not optimally calibrated, particularly in regards to IM diplotypes and the *2 allele. Additional research is needed to improve the prediction of CYP2D6 activity from genetic data for individualized dosing of CYP2D6 dependent drugs.

Published
2015
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8. Tamoxifen Dose Escalation in Patients With Diminished CYP2D6 Activity Normalizes Endoxifen Concentrations Without Increasing Toxicity

Author

Hertz, Daniel L., primary, Deal, Allison, additional, Ibrahim, Joseph G., additional, Walko, Christine M., additional, Weck, Karen E., additional, Anderson, Steven, additional, Magrinat, Gustav, additional, Olajide, Oludamilola, additional, Moore, Susan, additional, Raab, Rachel, additional, Carrizosa, Daniel R., additional, Corso, Steven, additional, Schwartz, Garry, additional, Graham, Mark, additional, Peppercorn, Jeffrey M., additional, Jones, David R., additional, Desta, Zeruesenay, additional, Flockhart, David A., additional, Evans, James P., additional, McLeod, Howard L., additional, Carey, Lisa A., additional, and Irvin, William J., additional

Published
2016
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10. In vivoassessment of the metabolic activity of CYP2D6 diplotypes and alleles

Author

Hertz, Daniel L., primary, Snavely, Anna C., additional, McLeod, Howard L., additional, Walko, Christine M., additional, Ibrahim, Joseph G., additional, Anderson, Steven, additional, Weck, Karen E., additional, Magrinat, Gustav, additional, Olajide, Oludamilola, additional, Moore, Susan, additional, Raab, Rachel, additional, Carrizosa, Daniel R., additional, Corso, Steven, additional, Schwartz, Garry, additional, Peppercorn, Jeffrey M., additional, Evans, James P., additional, Jones, David R., additional, Desta, Zeruesenay, additional, Flockhart, David A., additional, Carey, Lisa A., additional, and Irvin, William J., additional

Published
2015
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11. Abstract P1-03-02: CYP2D6 intermediate metabolizers includes patient groups with distinct metabolic activity

Author

Hertz, Daniel L, primary, Snavely, Anna C, additional, McLeod, Howard L, additional, Walko, Christine M, additional, Ibrahim, Joseph G, additional, Anderson, Steven, additional, Weck, Karen E, additional, Rubin, Peter, additional, Olajide, Oludamilola, additional, Moore, Susan, additional, Raab, Rachel, additional, Carrizosa, Daniel R, additional, Corso, Steven, additional, Schwartz, Gary, additional, Peppercorn, Jeffrey M, additional, Evans, James P, additional, Desta, Zeruesenay, additional, Flockhart, David A, additional, Carey, Lisa A, additional, and Irvin, William J, additional

Published
2015
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12. Does increasing the daily tamoxifen dose in patients with diminished CYP2D6 activity increase toxicity?

Author

Hertz, Daniel Louis, primary, Snavely, Anna C., additional, Evans, James P, additional, Ibrahim, Joseph G, additional, Anderson, Steven M., additional, Friedman, Kenneth J, additional, Weck, Karen E, additional, Rubin, Peter, additional, Olajide, Oludamilola A., additional, Moore, Susan G., additional, Raab, Rachel Elizabeth, additional, Carrizosa, Daniel R., additional, Corso, Steven William, additional, Schwartz, Garry, additional, Peppercorn, Jeffrey M., additional, Graham, Mark, additional, Canale, Sean Thomas, additional, McLeod, Howard L., additional, Carey, Lisa A., additional, and Irvin, William Johnson, additional

Published
2014
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14. Genome-wide profiles of CtBP link metabolism with genome stability and epithelial reprogramming in breast cancer

Author

Di, Li-Jun, primary, Byun, Jung S., additional, Wong, Madeline M., additional, Wakano, Clay, additional, Taylor, Tara, additional, Bilke, Sven, additional, Baek, Songjoon, additional, Hunter, Kent, additional, Yang, Howard, additional, Lee, Maxwell, additional, Zvosec, Cecilia, additional, Khramtsova, Galina, additional, Cheng, Fan, additional, Perou, Charles M., additional, Ryan Miller, C., additional, Raab, Rachel, additional, Olopade, Olufunmilayo I., additional, and Gardner, Kevin, additional

Published
2013
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16. Genotype-Guided Tamoxifen Dosing Increases Active Metabolite Exposure in Women With Reduced CYP2D6 Metabolism: A Multicenter Study

Author

Irvin, William J., primary, Walko, Christine M., additional, Weck, Karen E., additional, Ibrahim, Joseph G., additional, Chiu, Wing K., additional, Dees, E. Claire, additional, Moore, Susan G., additional, Olajide, Oludamilola A., additional, Graham, Mark L., additional, Canale, Sean T., additional, Raab, Rachel E., additional, Corso, Steven W., additional, Peppercorn, Jeffrey M., additional, Anderson, Steven M., additional, Friedman, Kenneth J., additional, Ogburn, Evan T., additional, Desta, Zeruesenay, additional, Flockhart, David A., additional, McLeod, Howard L., additional, Evans, James P., additional, and Carey, Lisa A., additional

Published
2011
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