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Your search keyword '"Raaz-Schrauder, Dorette"' showing total 23 results
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23 results on '"Raaz-Schrauder, Dorette"'

10. Genome-wide association study identifies a new locus for coronary artery disease on chromosome 10p11.23

Author

Erdmann, Jeanette, Willenborg, Christina, Nahrstaedt, Janja, Preuss, Michael, König, Inke R., Baumert, Jens, Linsel-Nitschke, Patrick, Gieger, Christian, Tennstedt, Stephanie, Belcredi, Petra, Aherrahrou, Zouhair, Klopp, Norman, Loley, Christina, Stark, Klaus, Hengstenberg, Christian, Bruse, Petra, Freyer, Jennifer, Wagner, Arnika K., Medack, Anja, Lieb, Wolfgang, Grohennig, Anika, Sager, Hendrik B., Reinhardt, Adrian, Schäfer, Arne, Schreiber, Stefan, El Mokhtari, Nour Eddine, Raaz-Schrauder, Dorette, Illig, Thomas, Garlichs, Christoph D., Ekici, Arif B., Reis, André, Schrezenmeir, Jürgen, Rubin, Diana, Ziegler, Andreas, Wichmann, H.-E., Doering, Angela, Meisinger, Christa, Meitinger, Thomas, Peters, Annette, and Schunkert, Heribert

Published
2011
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11. Pericoronary Adipose Tissue CT Attenuation And Its Association With Coronary Calcification And Serum Levels Of Pro- And Anti-inflammatory Mediators

Author

Göller, Markus, primary, Achenbach, Stephan, additional, Herrmann, Nicolai, additional, Bittner, Daniel O., additional, Ammon, Fabian, additional, Kilian, Tobias, additional, Smolka, Silvia, additional, Podzus, Julia, additional, Troebs, Monique, additional, Raaz-Schrauder, Dorette, additional, Dey, Damini, additional, and Marwan, Mohamed, additional

Published
2020
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13. Filarial extract of Litomosoides sigmodontis induces a type 2 immune response and attenuates plaque development in hyperlipidemic ApoE‐knockout mice

Author

Kuehn, Constanze, primary, Tauchi, Miyuki, additional, Furtmair, Roman, additional, Urschel, Katharina, additional, Raaz‐Schrauder, Dorette, additional, Neumann, Anna‐Lena, additional, Frohberger, Stefan J., additional, Hoerauf, Achim, additional, Regus, Susanne, additional, Lang, Werner, additional, Sagban, Tolga Atilla, additional, Stumpfe, Florian Matthias, additional, Achenbach, Stephan, additional, Hübner, Marc P., additional, and Dietel, Barbara, additional

Published
2019
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14. Correction: Enzymatic lipid oxidation by eosinophils propagates coagulation, hemostasis, and thrombotic disease

Author

Uderhardt, Stefan, primary, Ackermann, Jochen A., additional, Fillep, Tobias, additional, Hammond, Victoria J., additional, Willeit, Johann, additional, Santer, Peter, additional, Mayr, Manuel, additional, Biburger, Markus, additional, Miller, Meike, additional, Zellner, Katie R., additional, Stark, Konstantin, additional, Zarbock, Alexander, additional, Rossaint, Jan, additional, Schubert, Irene, additional, Mielenz, Dirk, additional, Dietel, Barbara, additional, Raaz-Schrauder, Dorette, additional, Ay, Cihan, additional, Gremmel, Thomas, additional, Thaler, Johannes, additional, Heim, Christian, additional, Herrmann, Martin, additional, Collins, Peter W., additional, Schabbauer, Gernot, additional, Mackman, Nigel, additional, Voehringer, David, additional, Nadler, Jerry L., additional, Lee, James J., additional, Massberg, Steffen, additional, Rauh, Manfred, additional, Kiechl, Stefan, additional, Schett, Georg, additional, O’Donnell, Valerie B., additional, and Krönke, Gerhard, additional

Published
2018
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15. Enzymatic lipid oxidation by eosinophils propagates coagulation, hemostasis, and thrombotic disease

Author

Uderhardt, Stefan, Ackermann, Jochen, Fillep, Tobias, Hammond, Victoria J., Willeit, Johann, Santer, Peter, Mayr, Manuel, Biburger, Markus, Miller, Meike, Zellner, Katie R., Stark, Konstantin, Zarbock, Alexander, Rossaint, Jan, Schubert, Irene, Mielenz, Dirk, Diete, Barbara, Raaz-Schrauder, Dorette, Ay, Cihan, Gremmel, Thomas, Thaler, Johannes, Heim, Christian, Herrmann, Martin, Collins, Peter W., Schabbauer, Gernot, Mackman, Nigel, Voehringer, David, Nadler, Jerry L., Lee, James J., Massberg, Steffen, Rauh, Manfred, Kiechl, Stefan, Schett, Georg, O'Donnell, Valerie B., and Krönke, Gerhard

Subjects
Adult, Blotting, Western, Arachidonate 12-Lipoxygenase, Risk Factors, Hydroxyeicosatetraenoic Acids, Animals, Arachidonate 15-Lipoxygenase, Humans, Prospective Studies, Blood Coagulation, Cells, Cultured, Aged, Mice, Knockout, Hemostasis, Reverse Transcriptase Polymerase Chain Reaction, Phosphatidylethanolamines, Eosinophil Cationic Protein, Thrombin, Correction, Thrombosis, Middle Aged, Atherosclerosis, R1, Lipids, Eosinophils, Mice, Inbred C57BL, Logistic Models, Oxidation-Reduction
Abstract

Blood coagulation is essential for physiological hemostasis, but simultaneously contributes to thrombotic disease. However, molecular and cellular events controlling initiation and propagation of coagulation are still incompletely understood. Here we demonstrate an unexpected role of eosinophils during plasmatic coagulation, hemostasis and thrombosis. Using a large-scale epidemiological approach, we identified eosinophil cationic protein (ECP) as independent and predictive risk factor for thrombotic events in humans. Concurrent experiments showed that eosinophils contributed to intravascular thrombosis by exhibiting a strong endogenous thrombin-generation capacity, which relied on the enzymatic generation and active provision of a pro-coagulant phospholipid-surface enriched in 12/15-lipoxygenase (12/15-LO)-derived hydroxyeicosatetraenoic acid-phosphatidylethanolamines. Our findings reveal a previously unrecognized role of eosinophils and enzymatic lipid oxidation as regulatory elements that facilitate both hemostasis and thrombosis in response to vascular injury, thus identifying promising new targets for the treatment of thrombotic disease.

Published
2016

18. Enzymatic lipid oxidation by eosinophils propagates coagulation, hemostasis, and thrombotic disease

Author

Uderhardt, Stefan, primary, Ackermann, Jochen A., additional, Fillep, Tobias, additional, Hammond, Victoria J., additional, Willeit, Johann, additional, Santer, Peter, additional, Mayr, Manuel, additional, Biburger, Markus, additional, Miller, Meike, additional, Zellner, Katie R., additional, Stark, Konstantin, additional, Zarbock, Alexander, additional, Rossaint, Jan, additional, Schubert, Irene, additional, Mielenz, Dirk, additional, Dietel, Barbara, additional, Raaz-Schrauder, Dorette, additional, Ay, Cihan, additional, Gremmel, Thomas, additional, Thaler, Johannes, additional, Heim, Christian, additional, Herrmann, Martin, additional, Collins, Peter W., additional, Schabbauer, Gernot, additional, Mackman, Nigel, additional, Voehringer, David, additional, Nadler, Jerry L., additional, Lee, James J., additional, Massberg, Steffen, additional, Rauh, Manfred, additional, Kiechl, Stefan, additional, Schett, Georg, additional, O’Donnell, Valerie B., additional, and Krönke, Gerhard, additional

Published
2017
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19. Patients with unstable angina pectoris show an increased frequency of the Fc gamma RIIa R131 allele

Author

Raaz-Schrauder, Dorette, primary, Ekici, Arif B., additional, Munoz, Luis E., additional, Klinghammer, Lutz, additional, Voll, Reinhard E., additional, Leusen, Jeanette H.W., additional, van de Winkel, Jan G.J., additional, Reis, André, additional, Schett, Georg, additional, Garlichs, Christoph D., additional, and Herrmann, Martin, additional

Published
2012
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20. Genetic Regulation of Serum Phytosterol Levels and Risk of Coronary Artery Disease

Author

Teupser, Daniel, primary, Baber, Ronny, additional, Ceglarek, Uta, additional, Scholz, Markus, additional, Illig, Thomas, additional, Gieger, Christian, additional, Holdt, Lesca M., additional, Leichtle, Alexander, additional, Greiser, Karin H., additional, Huster, Dominik, additional, Linsel-Nitschke, Patrick, additional, Schäfer, Arne, additional, Braund, Peter S., additional, Tiret, Laurence, additional, Stark, Klaus, additional, Raaz-Schrauder, Dorette, additional, Fiedler, Georg M., additional, Wilfert, Wolfgang, additional, Beutner, Frank, additional, Gielen, Stephan, additional, Großhennig, Anika, additional, König, Inke R., additional, Lichtner, Peter, additional, Heid, Iris M., additional, Kluttig, Alexander, additional, El Mokhtari, Nour E., additional, Rubin, Diana, additional, Ekici, Arif B., additional, Reis, André, additional, Garlichs, Christoph D., additional, Hall, Alistair S., additional, Matthes, Gert, additional, Wittekind, Christian, additional, Hengstenberg, Christian, additional, Cambien, Francois, additional, Schreiber, Stefan, additional, Werdan, Karl, additional, Meitinger, Thomas, additional, Loeffler, Markus, additional, Samani, Nilesh J., additional, Erdmann, Jeanette, additional, Wichmann, H.-Erich, additional, Schunkert, Heribert, additional, and Thiery, Joachim, additional

Published
2010
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23. Enzymatic lipid oxidation by eosinophils propagates coagulation, hemostasis, and thrombotic disease

Author

Schabbauer, Gernot, Raaz-Schrauder, Dorette, Biburger, Markus, Mielenz, Dirk, Willeit, Johann, Zarbock, Alexander, Fillep, Tobias, Mackman, Nigel, Zellner, Katie R., Stark, Konstantin, Rauh, Manfred, Santer, Peter, Gremmel, Thomas, Krönke, Gerhard, Collins, Peter W., Herrmann, Martin, Ackermann, Jochen A., Schubert, Irene, Mayr, Manuel, Miller, Meike, Massberg, Steffen, Heim, Christian, Uderhardt, Stefan, Thaler, Johannes, Dietel, Barbara, O'Donnell, Valerie B., Kiechl, Stefan, Rossaint, Jan, Lee, James J., Hammond, Victoria J., Ay, Cihan, Voehringer, David, Schett, Georg, and Nadler, Jerry L.

Subjects
3. Good health
Abstract

Blood coagulation is essential for physiological hemostasis but simultaneously contributes to thrombotic disease. However, molecular and cellular events controlling initiation and propagation of coagulation are still incompletely understood. In this study, we demonstrate an unexpected role of eosinophils during plasmatic coagulation, hemostasis, and thrombosis. Using a large-scale epidemiological approach, we identified eosinophil cationic protein as an independent and predictive risk factor for thrombotic events in humans. Concurrent experiments showed that eosinophils contributed to intravascular thrombosis by exhibiting a strong endogenous thrombin-generation capacity that relied on the enzymatic generation and active provision of a procoagulant phospholipid surface enriched in 12/15-lipoxygenase–derived hydroxyeicosatetraenoic acid–phosphatidylethanolamines. Our findings reveal a previously unrecognized role of eosinophils and enzymatic lipid oxidation as regulatory elements that facilitate both hemostasis and thrombosis in response to vascular injury, thus identifying promising new targets for the treatment of thrombotic disease.

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