463 results on '"Rabbitts, Terence H"'
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2. Structure-based development of new RAS-effector inhibitors from a combination of active and inactive RAS-binding compounds
3. Pre-clinical Modelling of Chromosomal Translocations and Inversions
4. Salmonella-based platform for efficient delivery of functional binding proteins to the cytosol
5. Inadequate Lung Development and Bronchial Hyperplasia in Mice with a Targeted Deletion in the Dutt1/Robo1 Gene
6. Intracellular Antibody-Caspase-Mediated Cell Killing: An Approach for Application in Cancer Therapy
7. The Oncogenic LIM-Only Transcription Factor Lmo2 Regulates Angiogenesis but Not Vasculogenesis in Mice
8. Selection of Antibodies for Intracellular Function Using a Two-Hybrid in vivo System
9. The T Cell Leukemia LIM Protein Lmo2 is Necessary for Adult Mouse Hematopoiesis
10. Exploring the surfaceome of Ewing sarcoma identifies a new and unique therapeutic target
11. KRAS-specific inhibition using a DARPin binding to a site in the allosteric lobe
12. Cancer cell killing by target antigen engagement with engineered complementary intracellular antibody single domains fused to pro-caspase3
13. Surfaceome interrogation using an RNA-seq approach highlights leukemia initiating cell biomarkers in an LMO2 T cell transgenic model
14. Supplementary Figures 1 - 5 from Sequential Gene Targeting to Make Chimeric Tumor Models with De Novo Chromosomal Abnormalities
15. Data from Sequential Gene Targeting to Make Chimeric Tumor Models with De Novo Chromosomal Abnormalities
16. ABT-199 mediated inhibition of BCL-2 as a novel therapeutic strategy in T-cell acute lymphoblastic leukemia
17. Identification of a minority population of LMO2+breast cancer cells that integrate into the vasculature and initiate metastasis
18. Intracellular antibody capture: A molecular biology approach to inhibitors of protein–protein interactions
19. Blocking oncogenic RAS enhances tumour cell surface MHC class I expression but does not alter susceptibility to cytotoxic lymphocytes
20. Small molecule inhibitors of RAS-effector protein interactions derived using an intracellular antibody fragment
21. Requirement for Lyl1 in a model of Lmo2-driven early T-cell precursor ALL
22. Distinct pathways regulated by menin and by MLL1 in hematopoietic stem cells and developing B cells
23. The Lmo2 Oncogene Initiates Leukemia in Mice by Inducing Thymocyte Self-Renewal
24. Single Domain Intracellular Antibodies from Diverse Libraries: EMPHASIZING DUAL FUNCTIONS OF LMO2 PROTEIN INTERACTIONS USING A SINGLE VH DOMAIN
25. A tetrameric ACE2 protein broadly neutralizes SARS-CoV-2 spike variants of concern with elevated potency
26. Commonality but Diversity in Cancer Gene Fusions
27. Analysis of a T-Cell Tumor-Specific Breakpoint Cluster at Human Chromosome 14q32
28. Structure and Multiplicity of Genes for the Human Immunoglobulin Heavy Chain Variable Region
29. Membrane-Bound Ribosomes of Myeloma Cells. IV. mRNA Complexity of Free and Membrane-Bound Polysomes
30. Changing the Subcellular Location of the Oncoprotein Bcr-Abl Using Rationally Designed Capture Motifs
31. Functional Intracellular Antibody Fragments Do Not Require Invariant Intra-domain Disulfide Bonds
32. The role of Slit-Robo signaling in the generation, migration and morphological differentiation of cortical interneurons
33. LMO2 is critical for early metastatic events in breast cancer
34. Tumour prevention by a single antibody domain targeting the interaction of signal transduction proteins with RAS
35. Interrogation of genomes by molecular copy-number counting (MCC)
36. Mll fusions generated by Cre‐loxP‐mediated de novo translocations can induce lineage reassignment in tumorigenesis
37. A cell-based screening method using an intracellular antibody for discovering small molecules targeting the translocation protein LMO2
38. Intrabodies based on intracellular capture frameworks that bind the RAS protein with high affinity and impair oncogenic transformation
39. Selection of Functional Single Domain Antibody Fragments for Interfering with Protein–Protein Interactions Inside Cells: A “One Plasmid” Mammalian Two-Hybrid System
40. Intracellular Antibody Capture (IAC) Methods for Single Domain Antibodies
41. The LIM-domain protein Lmo2 is a key regulator of tumour angiogenesis: a new anti-angiogenesis drug target
42. Chromosomal translocation products engender new intracellular therapeutic technologies
43. Chromosomal translocation master genes, mouse models and experimental therapeutics
44. T cell tumorigenesis in Lmo2 transgenic mice is independent of V-D-J recombinase activity
45. The Role of LMO2 in Development and in T Cell Leukemia After Chromosomal Translocation or Retroviral Insertion
46. Inter‐chromosomal recombination of Mll and Af9 genes mediated by cre‐loxP in mouse development
47. Masked antisense: a molecular configuration for discriminating similar RNA targets
48. Structural basis for the heterodimeric interaction between the acute leukaemia‐associated transcription factors AML1 and CBFβ
49. Tumorigenesis in mice with a fusion of the leukaemia oncogene Mll and the bacterial lacZ gene
50. Characterization of the Lmo4 gene encoding a LIM-only protein: genomic organization and comparative chromosomal mapping
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