132 results on '"Rabey, M"'
Search Results
2. 1304P Investigator-initiated study of crizotinib in patients with MET activated advanced stage non-small cell lung cancer: A Canadian experience
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Alghabban, A.J., Sacher, A.G., Shepherd, F.A., Bradbury, P.A., Eng, L., Liu, G., Xie, D., Wozniczka, I., Saf, M., Le, L., Rabey, M., Zhang, T., Sabantini, P., and Leighl, N.B.
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- 2024
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3. 1236P ctDNA-Lung-Detect: Profiling of non-shedding ctDNA early stage resected non-small cell lung cancers
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Khan, S., Feng, J., Waddell, T.K., Yasufuku, K., Pierre, A., Keshavjee, S., Yeung, J., Cypel, M., Donahoe, L., Wakem, E., de Perrot, M., Salvarrey, A., Safieddine, N., Ko, M., Parente, D., Rabey, M., Le, L., Pipinikas, C., Chevalier, A., and Leighl, N.B.
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- 2024
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4. Effect of Graded Sensorimotor Retraining on Pain Intensity in Patients With Chronic Low Back Pain: A Randomized Clinical Trial.
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Bagg, MK, Wand, BM, Cashin, AG, Lee, H, Hübscher, M, Stanton, TR, O'Connell, NE, O'Hagan, ET, Rizzo, RRN, Wewege, MA, Rabey, M, Goodall, S, Saing, S, Lo, SN, Luomajoki, H, Herbert, RD, Maher, CG, Moseley, GL, McAuley, JH, Bagg, MK, Wand, BM, Cashin, AG, Lee, H, Hübscher, M, Stanton, TR, O'Connell, NE, O'Hagan, ET, Rizzo, RRN, Wewege, MA, Rabey, M, Goodall, S, Saing, S, Lo, SN, Luomajoki, H, Herbert, RD, Maher, CG, Moseley, GL, and McAuley, JH
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Importance: The effects of altered neural processing, defined as altering neural networks responsible for perceptions of pain and function, on chronic pain remains unclear. Objective: To estimate the effect of a graded sensorimotor retraining intervention (RESOLVE) on pain intensity in people with chronic low back pain. Design, Setting, and Participants: This parallel, 2-group, randomized clinical trial recruited participants with chronic (>3 months) nonspecific low back pain from primary care and community settings. A total of 276 adults were randomized (in a 1:1 ratio) to the intervention or sham procedure and attention control groups delivered by clinicians at a medical research institute in Sydney, Australia. The first participant was randomized on December 10, 2015, and the last was randomized on July 25, 2019. Follow-up was completed on February 3, 2020. Interventions: Participants randomized to the intervention group (n = 138) were asked to participate in 12 weekly clinical sessions and home training designed to educate them about and assist them with movement and physical activity while experiencing lower back pain. Participants randomized to the control group (n = 138) were asked to participate in 12 weekly clinical sessions and home training that required similar time as the intervention but did not focus on education, movement, and physical activity. The control group included sham laser and shortwave diathermy applied to the back and sham noninvasive brain stimulation. Main Outcomes and Measures: The primary outcome was pain intensity at 18 weeks, measured on an 11-point numerical rating scale (range, 0 [no pain] to 10 [worst pain imaginable]) for which the between-group minimum clinically important difference is 1.0 point. Results: Among 276 randomized patients (mean [SD] age, 46 [14.3] years; 138 [50%] women), 261 (95%) completed follow-up at 18 weeks. The mean pain intensity was 5.6 at baseline and 3.1 at 18 weeks in the intervention group and 5.8 at
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- 2022
5. Vestibulocervical reflexes in idiopathic Parkinson disease
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Pollak, L., Prohorov, T., Kushnir, M., and Rabey, M.
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- 2009
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6. Do chronic low back pain subgroups derived from dynamic quantitative sensory testing exhibit differing multidimensional profiles?
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Rabey, M., Kendell, Michelle, Koren, S., Silva, I., Watts, L., Wong, C., Slater, Helen, Smith, Anne, Beales, Darren, Rabey, M., Kendell, Michelle, Koren, S., Silva, I., Watts, L., Wong, C., Slater, Helen, Smith, Anne, and Beales, Darren
- Abstract
The relationship of pain sensitivity with pain and disability in low back pain (LBP) is complicated. It has been suggested increased understanding of dynamic quantitative sensory testing (QST) might be useful in increasing understanding of these relationships. This study aimed to create subgroups based on participant responses to dynamic QST, profile these subgroups based on multidimensional variables (including clinical measures of pain and disability, psychological and lifestyle variables and static QST), and investigate the association of subgroup membership with levels of pain intensity, LBP-related disability and disability risk at 12-month follow up. Participants (n=273) with dominant axial chronic non-specific LBP with duration of pain >3 months were included in this study. At baseline, eligible participants completed a self-report questionnaire to collect demographic, clinical, psychological and lifestyle data prior to dynamic and static QST. Dynamic QST measures were conditioned pain modulation (CPM) and temporal summation (TS). At 12-months follow up, clinical data were collected, including pain intensity and LBP-related disability. Sub-groups were formed by cross-tabulation. Analysis was undertaken to profile dynamic QST subgroup on demographic, clinical, psychological, lifestyle and static QST measures. Associations between dynamic QST subgroups and follow-up clinical variables were examined. Based on dynamic QST, participants were allocated into four subgroups; normal CPM and normal TS (n=34, 12.5%); normal CPM and facilitated TS (n=6, 2.2%); impaired CPM and normal TS (n=186, 68.1%); impaired CPM and facilitated TS (n=47, 17.2%). At baseline no differences were demonstrated between subgroups across most clinical variables, or any psychological or lifestyle measures. The two subgroups with impaired CPM were more likely to have a higher number of painful body areas. Cold pain sensitivity was heightened in both the subgroups with facilitated TS. Subgroups
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- 2021
7. Infectious inflammation of the CNS involves activation of mitogen-activated protein kinase and AKT proteins in CSF in humans
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Pollak, L., Hanoch, T., Rabey, M. J., and Seger, R.
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- 2005
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8. Increased L-DOPA-derived dopamine following selective MAO-A or -B inhibition in rat striatum depleted of dopaminergic and serotonergic innervation
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Sader-Mazbar, O, Loboda, Y, Rabey, M J, and Finberg, J P M
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- 2013
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9. Pastores del altiplano andino meridional: religiosidad, territorio y equilibrio ecológico
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Merlino, R. J., primary and Rabey, M. A., primary
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- 2020
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10. Clinical characteristics of patients with ischemic ocular nerve palsies and lacunar brain infarcts: a retrospective comparative study
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Pollak, L., Kessler, A., Rabey, M. J., Hartmann, B., and Goldhammer, Y.
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- 2005
11. Bilateral vestibular failure as a unique presenting sign in carcinomatous meningitis: case report
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POLLAK, L, MILO, R, KOSSYCH, V, RABEY, M J, and SHAPIRA, E
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- 2001
12. The predictive ability of the STarT Back Tool was limited in people with chronic low back pain: a prospective cohort study
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Kendell, M., Beales, Darren, O'Sullivan, Peter, Rabey, M., Hill, J., Smith, Anne, Kendell, M., Beales, Darren, O'Sullivan, Peter, Rabey, M., Hill, J., and Smith, Anne
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© 2018 Australian Physiotherapy Association Questions: In people with chronic non-specific low back pain (LBP), what is the predictive and discriminative validity of the STarT Back Tool (SBT) for pain intensity, self-reported LBP-related disability, and global self-perceived change at 1-year follow-up? What is the profile of the SBT risk subgroups with respect to demographic variables, pain intensity, self-reported LBP-related disability, and psychological measures? Design: Prospective cohort study. Participants: A total of 290 adults with dominant axial LBP of ≥ 3 months’ duration recruited from the general community, and private physiotherapy, psychology, and pain-management clinics in Western Australia. Outcome measures: The 1-year follow-up measures were pain intensity, LBP-related disability, and global self-perceived change. Results: Outcomes were collected on 264 participants. The SBT categorised 82 participants (28%) as low risk, 116 (40%) as medium risk, and 92 (32%) as high risk. The risk subgroups differed significantly (p < 0.05) on baseline pain, disability, and psychological scores. The SBT's predictive ability was strongest for disability: RR was 2.30 (95% CI 1.28 to 4.10) in the medium-risk group and 2.86 (95% CI 1.60 to 5.11) in the high-risk group. The SBT's predictive ability was weaker for pain: RR was 1.25 (95% CI 1.04 to 1.51) in the medium-risk group and 1.26 (95% CI 1.03 to 1.52) in the high-risk group. For the SBT total score, the AUC was 0.71 (95% CI 0.64 to 0.77) for disability and 0.63 (95% CI 0.55 to 0.71) for pain. Conclusion: This was the first large study to investigate the SBT in a population exclusively with chronic LBP. The SBT provided an acceptable indication of 1-year disability, had poor predictive and discriminative ability for future pain, and was unable to predict or discriminate global perceived change. In this cohort with chronic non-specific LBP, the SBT's predictive and discriminative abilities were restricted to
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- 2018
13. Differing psychologically-derived clusters in people with chronic low back pain are associated with different multidimensional profiles
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Rabey, M., primary, Smith, A., additional, Beales, D., additional, Slater, H., additional, and O'Sullivan, P., additional
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- 2017
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14. To subgroup, or not to subgroup?
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Rabey, M., primary, Smith, A., additional, Beales, D., additional, Slater, H., additional, and O'Sullivan, P., additional
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- 2017
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15. The RESOLVE Trial for people with chronic low back pain: protocol for a randomised clinical trial
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Bagg, MK, Hübscher, M, Rabey, M, Wand, BM, O'Hagan, E, Moseley, GL, Stanton, TR, Maher, CG, Goodall, S, Saing, S, O'Connell, NE, Luomajoki, H, McAuley, JH, Bagg, MK, Hübscher, M, Rabey, M, Wand, BM, O'Hagan, E, Moseley, GL, Stanton, TR, Maher, CG, Goodall, S, Saing, S, O'Connell, NE, Luomajoki, H, and McAuley, JH
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© 2016 Australian Physiotherapy Association Introduction Low back pain is the leading worldwide cause of disability, and results in significant personal hardship. Most available treatments, when tested in high-quality randomised, controlled trials, achieve only modest improvements in pain, at best. Recently, treatments that target central nervous system function have been developed and tested in small studies. Combining treatments that target central nervous system function with traditional treatments directed towards functioning of the back is a promising approach that has yet to be tested in adequately powered, prospectively registered, clinical trials. The RESOLVE trial will be the first high-quality assessment of two treatment programs that combine central nervous system-directed and traditional interventions in order to improve chronic low back pain. Aim To compare the effectiveness of two treatment programs that combine central nervous system-directed and traditional interventions at reducing pain intensity at 18 weeks post randomisation in a randomised clinical trial of people with chronic low back pain. Design Two-group, randomised, clinical trial with blinding of participants and assessors. Participants and setting Two hundred and seventy-five participants with chronic low back pain that has persisted longer than 3 months and no specific spinal pathology will be recruited from the community and primary care in Sydney, Australia. Interventions Both of the interventions contain treatments that target central nervous system function combined with treatments directed towards functioning of the back. Adherence to the intervention will be monitored using an individual treatment diary and adverse events recorded through passive capture. Participants are informed prior to providing informed consent that some of the treatments are not active. Blinding is maintained by not disclosing any further information. Complete disclosure of the contents of the intervention has
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- 2017
16. Response to: “Letter to the Editor entitled: Unjustified extrapolation” [by authors: Supp G., Rosedale R., Werneke M.]
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Rabey, M., Smith, Anne, Beales, Darren, Slater, Helen, O'Sullivan, Peter, Rabey, M., Smith, Anne, Beales, Darren, Slater, Helen, and O'Sullivan, Peter
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- 2017
17. Reconceptualising manual therapy skills in contemporary practice
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Rabey, M., Hall, Toby, Hebron, C., Palsson, T., Christensen, S., Moloney, N., Rabey, M., Hall, Toby, Hebron, C., Palsson, T., Christensen, S., and Moloney, N.
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© 2017 Elsevier Ltd. With conflicting evidence regarding the effectiveness of manual therapy calls have arisen within some quarters of the physiotherapy profession challenging the continued use of manual skills for assessment and treatment. A reconceptualisation of the importance of manual examination findings is put forward, based upon a contemporary understanding of pain science, rathe r than considering these skills only in terms of how they should “guideâ€? manual therapy interventions. The place for manual examination findings within complex, multidimensional presentations is considered using vignettes describing the presentations of five people with low back pain. As part of multidimensional, individualised management, the balance of evidence relating to the effectiveness, mechanisms of action and rationale for manual skills is discussed. It is concluded that if manual examination and therapeutic skills are used in a manner consistent with a contemporary understanding of pain science, multidimensional patient profiles and a person-centred approach, their selective and judicious use still has an important role.
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- 2017
18. Multidimensional Prognostic Modelling in People with Chronic Axial Low Back Pain
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Rabey, M., Smith, Anne, Beales, Darren, Slater, Helen, O'Sullivan, Peter, Rabey, M., Smith, Anne, Beales, Darren, Slater, Helen, and O'Sullivan, Peter
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Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved. Objectives: To derive prognostic models for people with chronic low back pain (CLBP) (n=294) based upon an extensive array of potentially prognostic multidimensional factors. Materials and Methods: This study entered multidimensional data (demographics, pain characteristics, pain responses to movement, behaviors associated with pain, pain sensitivity, psychological, social, health, lifestyle) at baseline, and interventions undertaken, into prognostic models for pain intensity, disability, global rating of change and bothersomeness at 1-year. Results: The prognostic model for higher pain intensity (explaining 23.2% of the variance) included higher baseline pain intensity and punishing spousal interactions, and lower years in education, while participating in exercise was prognostic of lower pain intensity. The model for higher disability (33.6% of the variance) included higher baseline disability, longer forward bending time, psychological principal component scores representing negative pain-related cognitions and punishing spousal interactions; while exercising was prognostic of lower disability. The odds of reporting global rating of change much/very much improved were increased by participating in exercise, having leg pain as well as CLBP and having greater chronic pain acceptance. The receiver operating characteristic area under the curve was 0.72 indicating acceptable discrimination. The odds of reporting very/extremely bothersome CLBP were increased by having higher baseline pain intensity, longer forward bending time and receiving injection(s); while higher age, more years in education and having leg pain decreased the odds (receiver operating characteristic area under the curve, 0.80; acceptable discrimination). Discussion: The variance explained by prognostic models was similar to previous reports, despite an extensive array of multidimensional baseline variables. This highlights the inherent
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- 2017
19. Process of change in pain-related fear: Clinical insights from a single case report of persistent back pain managed with cognitive functional therapy
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Caneiro, J., Smith, Anne, Rabey, M., Moseley, G., O'Sullivan, Peter, Caneiro, J., Smith, Anne, Rabey, M., Moseley, G., and O'Sullivan, Peter
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STUDY DESIGN: Single case report with repeated measures over 18 months. BACKGROUND: Management of persistent low back pain (PLBP) associated with high pain-related fear is complex. This case report aims to provide clinicians with insight into the process of change in a person with PLBP and high bending-related fear, who was managed with an individualized behavioral approach of cognitive functional therapy. CASE DESCRIPTION: A retired manual worker with PLBP believed that his spine was degenerating, that bending would hurt him, and that avoidance was the only form of pain control. At baseline, he presented high levels of pain-related fear on the Tampa Scale of Kinesiophobia (score, 47/68) and a high-risk profile on the Örebro Musculoskeletal Pain Questionnaire (score, 61/100). Unhelpful beliefs and behaviors led to a vicious cycle of fear and disengagement from valued life activities. Guided behavioral experiments were used to challenge his thoughts and protective responses, indicating that his behavior was modifiable and the pain controllable. Using a multidimensional clinical-reasoning framework, cognitive functional therapy management was tailored to target key drivers of PLBP and delivered over 6 sessions in a 3-month period. OUTCOMES: Over an 18-month clinical journey, he demonstrated improvements in bending-related fear, pain expectancy, and pain experience, and substantial changes in pain-related fear (Tampa Scale of Kinesiophobia: 33/68; change, -14 points) and risk profile (Örebro Musculoskeletal Pain Questionnaire: 36/100; change, -25 points). Clinical interviews at 6 and 18 months revealed positive changes in mindset, understanding of pain, perceived pain control, and behavioral responses to pain. DISCUSSION: This case report provides clinicians with an insight to using a multidimensional clinical-reasoning framework to identify and target the key drivers of the disorder, and to using cognitive functional therapy to address unhelpful psychological and beha
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- 2017
20. Support for extended classification of pain states
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Moloney, N., Rabey, M., Nijs, J., Hush, J., Slater, Helen, Moloney, N., Rabey, M., Nijs, J., Hush, J., and Slater, Helen
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- 2017
21. International multicenter pilot study of the first comprehensive self-completed nonmotor symptoms questionnaire for Parkinson's disease: the NMSQuest study
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Chaudhuri KR, Martinez Martin P, Schapira AH, Stocchi F, Sethi K, Odin P, Brown RG, Koller W, MacPhee G, Kelly L, Rabey M, MacMahon D, Thomas S, Ondo W, Rye D, Forbes A, Tluk S, Dhawan V, Bowron A, Williams AJ, Olanow C.W., BARONE, PAOLO, Chaudhuri, Kr, Martinez Martin, P, Schapira, Ah, Stocchi, F, Sethi, K, Odin, P, Brown, Rg, Koller, W, Barone, Paolo, Macphee, G, Kelly, L, Rabey, M, Macmahon, D, Thomas, S, Ondo, W, Rye, D, Forbes, A, Tluk, S, Dhawan, V, Bowron, A, Williams, Aj, and Olanow, C. W.
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Aged, 80 and over ,Male ,Neurologic Examination ,Sick Role ,Parkinson Disease ,Pilot Projects ,Middle Aged ,Neuropsychological Tests ,Health Surveys ,Sickness Impact Profile ,Surveys and Questionnaires ,Outcome Assessment, Health Care ,Quality of Life ,Humans ,Female ,Aged - Abstract
Nonmotor symptoms (NMS) of Parkinson's disease (PD) are not well recognized in clinical practice, either in primary or in secondary care, and are frequently missed during routine consultations. There is no single instrument (questionnaire or scale) that enables a comprehensive assessment of the range of NMS in PD both for the identification of problems and for the measurement of outcome. Against this background, a multidisciplinary group of experts, including patient group representatives, has developed an NMS screening questionnaire comprising 30 items. This instrument does not provide an overall score of disability and is not a graded or rating instrument. Instead, it is a screening tool designed to draw attention to the presence of NMS and initiate further investigation. In this article, we present the results from an international pilot study assessing feasibility, validity, and acceptability of a nonmotor questionnaire (NMSQuest). Data from 123 PD patients and 96 controls were analyzed. NMS were highly significantly more prevalent in PD compared to controls (PD NMS, median = 9.0, mean = 9.5 vs. control NMS, median = 5.5, mean = 4.0; Mann-Whitney, Kruskal-Wallis, and t test, P0.0001), with PD patients reporting at least 10 different NMS on average per patient. In PD, NMS were highly significantly more prevalent across all disease stages and the number of symptoms correlated significantly with advancing disease and duration of disease. Furthermore, frequently, problems such as diplopia, dribbling, apathy, blues, taste and smell problems were never previously disclosed to the health professionals.
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- 2006
22. Disrupted Self-Perception in People With Chronic Low Back Pain. Further Evaluation of the Fremantle Back Awareness Questionnaire
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Wand, B., Catley, M., Rabey, M., O'Sullivan, Peter, O'Connell, N., Smith, A., Wand, B., Catley, M., Rabey, M., O'Sullivan, Peter, O'Connell, N., and Smith, A.
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Several lines of evidence suggest that body perception is altered in people with chronic back pain. Maladaptive perceptual awareness of the back might contribute to the pain experience as well as serve as a target for treatment. The Fremantle Back Awareness Questionnaire (FreBAQ) is a simple questionnaire recently developed to assess back-specific altered self-perception. The aims of this study were to present the outcomes of a comprehensive evaluation of the questionnaire's psychometric properties and explore the potential relationships between body perception, nociceptive sensitivity, distress, and beliefs about back pain and the contribution these factors might play in explaining pain and disability. Two hundred fifty-one people with chronic back pain completed the questionnaire as well as a battery of clinical tests. The Rasch model was used to explore the questionnaires' psychometric properties and correlation and multiple linear regression analyses were used to explore the relationship between altered body perception and clinical status. The FreBAQ appears unidimensional with no redundant items, has minimal ceiling and floor effects, acceptable internal consistency, was functional on the category rating scale, and was not biased by demographic or clinical variables. FreBAQ scores were correlated with sensitivity, distress, and beliefs and were uniquely associated with pain and disability.Perspective: Several lines of evidence suggest that body perception might be disturbed in people with chronic low back pain, possibly contributing to the condition and offering a potential target for treatment. The FreBAQ was developed as a quick and simple way of measuring back-specific body perception in people with chronic low back pain. The questionnaire appears to be a psychometrically sound way of assessing altered self-perception. The level of altered self-perception is positively correlated with pain intensity and disability as well as showing associations with psychol
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- 2016
23. The predictive ability of the start back screening tool was limited in a cohort with chronic low back pain
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Kendell, M., primary, Beales, D., additional, Smith, A., additional, O'Sullivan, P., additional, and Rabey, M., additional
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- 2016
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24. Pain provocation following repeated movements in people with chronic low back pain: Subgrouping and multidimensional profiles
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Rabey, M., primary, Smith, A., additional, Beales, D., additional, Slater, H., additional, and O'Sullivan, P., additional
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- 2016
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25. People with chronic axial low back pain have differing sensory characteristics
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Rabey, M., primary, O'Sullivan, P., additional, Slater, H., additional, Beales, D., additional, and Smith, A., additional
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- 2015
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26. Pro-nociceptive and anti-nociceptive effects of a conditioned pain modulation protocol in participants with chronic low back pain and healthy controls
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Rabey, M., primary, Poon, C., additional, Wray, J., additional, Thamajaree, C., additional, East, R., additional, and Slater, H., additional
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- 2015
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27. Generalized epileptic seizures as the presenting symptom of lacunar infarction in the brain
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Avrahami, E., Drory, V. E., Rabey, M. J., and Cohn, D. F.
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- 1988
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28. Pro-nociceptive and anti-nociceptive effects of a conditioned pain modulation protocol in participants with chronic low back pain and healthy control subjects
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Rabey, M., Poon, C., Wray, J., Thamajaree, C., East, R., Slater, Helen, Rabey, M., Poon, C., Wray, J., Thamajaree, C., East, R., and Slater, Helen
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Background: People with chronic pain may exhibit pro-nociceptive phenotypes characterised partly by reduced conditioned pain modulation (CPM). Characterising variability in CPM in people with chronic low back pain (CLBP) may inform management. Objectives: To investigate pro/anti-nociceptive effects of a CPM protocol in age/sex-matched healthy controls (HCs) and people with CLBP. Design: Case-controlled trial (64 participants/group). Method: The CPM protocol involved: test stimulus (TS) (noxious pressure applied by algometer to lumbar region); conditioning stimulus (CS) (noxious heat applied by thermode to dorsal hand). CPM recruitment was measured by the change in pain intensity (rated on a numeric rating scale (NRS)) of the TS in the presence and absence of the CS. Results: Responses to this CPM protocol were variable for both groups with measures consistent with either inhibitory or facilitatory effects. A significantly greater proportion of facilitatory responses were seen in the CLBP cohort compared to HCs (73% versus 31%). In response to the CS, participants with CLBP demonstrated a mean increase in NRS scores (mean 1.3 points; p<0.001), while HCs did not (mean-0.2 points; p=0.35) and the between-group difference in change scores was significant (mean 1.4 points; p<0.001; effect size (Hedges' g): 1.03). Conclusion: In HCs and participants with CLBP this CPM protocol elicited responses consistent with varying pro/anti-nociceptive effects. The higher proportion of participants with CLBP demonstrating a facilitatory response suggests a pro-nociceptive phenotype may characterise this cohort.
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- 2014
29. Electrophysiologic features in patients with chronic neurolathyrism
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Drory, V. E., primary, Rabey, M. J., additional, and Cohn, D. F., additional
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- 2009
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30. Body packer: cocaine intoxication, causing death, masked by concomitant administration of major tranquilizers
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Klein, C., primary, Balash, Y., additional, Pollak, L., additional, Hiss, J., additional, and Rabey, M. J., additional
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- 2000
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31. Persistent ocular lateropulsion in Wallenberg's syndrome responsive to phenytoin
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Pollak, L., primary, Klein, C., additional, Schiffer, J., additional, and Rabey, M. J., additional
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- 1997
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32. Long-term tolerability and efficacy of cabergoline, a new long-acting dopamine agonist, in Parkinson's disease
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Inzelberg, R., primary, Nisipeanu, P., additional, Rabey, M. J., additional, and Korczyn, A. D., additional
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- 1995
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33. Orthopaedic physiotherapy practitioners: surgical and radiological referral rates.
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Rabey M, Morgans S, and Barrett C
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Purpose-The purpose of this paper is to discuss the scepticism that persists among medics regarding appropriateness of some aspects of services provided by extended scope physiotherapists (ESPs). This paper aims to highlight the extent and appropriateness of surgical and radiological referrals by ESPs working in an adult orthopaedic service.Design/methodology/approach-The patient pathway following ESP assessment was audited over 31 months. Parameters explored included ESP referral rates to orthopaedic consultants; the percentage of patients where the entire episode of care was managed by the ESP; whether orthopaedic referrals were appropriate in terms of surgical interventions; and numbers of radiology referrals specifically for knee or lumbar complaints.Findings-Of the patients, 79 per cent had their entire episode of care managed by ESPs. Of the patients, 9 per cent were referred on for a surgical opinion (of which 42 per cent knees, 20 per cent lumbar). 13 per cent were referred for x-rays, 10 per cent for magnetic resonance imaging. Of the patients referred on for surgical opinion surgical intervention was appropriate in 89 per cent of cases.Research limitations/implications-Data from an ESP service with broad guiding protocols in a specific hospital are not readily extrapolated to ESPs elsewhere. Appropriateness of onwards referrals was based on the opinions of consultants to whom patients were referred. The potential benefit of a second opinion even if surgery is not offered is not taken into account by this model.Practical implications-These audits reinforce the impact ESPs have on efficiency within orthopaedics. They document referral rates for x-rays and magnetic resonance imaging by ESPs for lumbar and knee complaints that may benefit units proposing new ESP services.Originality/value-This paper reinforces published data on ESP management of the entire episode of care of the majority of referrals to orthopaedics, and on the highly appropriate nature of onwards referrals. Documented for possibly the first time, data regarding investigations for lumbar and knee disorders highlight low referral rates. [ABSTRACT FROM AUTHOR]
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- 2009
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34. Topiramate monotherapy as broad-spectrum antiepileptic drug in a naturalistic clinical setting
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Guerrini, R, Carpay, J, Grošelj, J, van Oene, J, Schreiner, A, Lahaye, M, Schwalen, S, Lagae, L, Sadzot, B, Van Bogaert, P, van Rijckevorsel, K, Willems, C., Alexiev, A., Bojinov, S., Chavdarov, D., Ganeva, G., Minchev, D., Hajnsek, Propadalo, Lusic, S., Marusic Della Marina, Paucic, Kirincic, Poljakovic, E., Skarpa, Z., Valic, D., Andersen, I., Anthonisen, A., Grønbech, Jensen, Gulliksen, M., Jansen, G., Luhdorf, J., Mai, K., Østergaard, J., Sørensen, S., Thorvaldsen, T., Worm, P., Talvik, M., Barthez, I., Toffol, De, Derambure, B., Hirsch, P., Josien, E., Pedespan, E., Rouselle, J., Mckee, C., Smith, P., Balogiannis, P., Diamantopoulos, N., Karageorgioy, K., Kyritsis, A., Mylonas, I., Papavasiliou, A., Piperidoy, H., Vassilopoulos, D., Neufeld, M., Rabey, M., Aguglia, U., Balestri, P., Capovilla, G., Cristofori, G., Perri, Di, Ganga, R., Garofalo, A., P. G., Gigli, Gian Luigi, Gobbi, G., Manfredi, M., Marciani, M. G., Martinuzzi, A., Michelucci, R., Minicucci, F., Romeo, A., Sasanelli, F., Veggiotti, P., Zucca, C., Yamani, Al, Jan, S., Yaqub, M., Shubaili, Al, Vtols, A., Mikati, E., Bejjani, M., Riachi, P., Den, Hartog, G. W. A., Hagemans, J. J. M., Hillegers, J. P. M., Kamphuis, D. J., Keunen, R. W. M., Koehler, P. J. J., Leyten, Q. A. H., Pop, P. H. M., Smits, M. G., Van der Leeuw, H. J. M., Van, Donselaar, C. A., Veering, M. M., Albretsen, Hagen, C., Kåss, T., Kinge, B., Lillebö, E., and Svendsen, A.
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Topiramate ,Adult ,Male ,Pediatrics ,medicine.medical_specialty ,Adolescent ,Broad-spectrum ,Antiepileptic drug ,Clinical Neurology ,Fructose ,Broad spectrum ,Epilepsy ,Patient satisfaction ,medicine ,Humans ,Generalized epilepsy ,Adverse effect ,Child ,Aged ,Aged, 80 and over ,business.industry ,Body Weight ,Age Factors ,Infant ,Focal epilepsy ,General Medicine ,Middle Aged ,medicine.disease ,Monotherapy ,Tolerability ,Neurology ,Patient Satisfaction ,Anesthesia ,Child, Preschool ,Anticonvulsants ,Female ,Neurology (clinical) ,business ,medicine.drug - Abstract
Topiramate was assessed in an open-label trial as broad-spectrum antiepileptic monotherapy, independently from the epilepsy type or syndrome. Adults and children aged 2 years and older, who were diagnosed with epilepsy within the last 5 years, treatment-naive or failing prior treatment with one antiepileptic drug (AED), received individually adjusted doses of topiramate, after escalation to 100mg/day over 4 weeks (maximum 400mg/day) or 3mg/kg/day over 6 weeks (maximum 9 mg/kg/day), respectively. Patients were followed foror=7 months and optionally up to a maximum of 13 months. Data were analysed for all patients (n=692), as well as for focal (n=421) and generalized epilepsies (n=148). The median topiramate dose used was 125 mg/day in adults and 3.3mg/kg/day in children (or=12 years). Overall, 80% of patients completed the 7-month study. During this period, 44.3% were seizure-free, while 76.3% achievedor=50% reduction in mean monthly seizure frequency. Patients with focal and generalized epilepsies alike responded to treatment (73.9 and 83.8% with at least 50% seizure reduction): 39.4% of patients with focal epilepsy and 61.5% of those with generalized epilepsy were seizure-free. The mean monthly seizure frequency was significantly reduced versus baseline at all visits (p0.001). Similar response rates were obtained from the 237 patients completing the 1-year observation period. During the mandatory 7-month period of study, 8.8% of patients reported insufficient tolerability as a reason for dropout. The most frequent adverse event was paraesthesia. Our results support findings that emerge from controlled studies that topiramate is effective and well tolerated when used as initial or second monotherapy. They also suggest that in a naturalistic setting, overall good retention on treatment and seizure freedom are observed at low doses in a broad spectrum of epilepsies.
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35. Pastores del altiplano andino meridional: religiosidad, territorio y equilibrio ecológico
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Merlino, R. J. and Rabey, M. A.
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Jujuy-Argentina ,religiosidad campesina ,etnografía - Abstract
En este trabajo presentamos una síntesis interpretativa de datos sobre religiosidad de los pastores, obtenidos en un área del Altiplano Andino Meridional, que se encuentra ubicada en el NO de la provincia argentina de Jujuy, cerca de los límites con Chile y Bolivia. Dichos datos fueron recogidos en tres trabajos de campo, llevados a cabo en distintos periodos de los años 1977, 1978 y 1979. Los mismos tuvieron como escenario principal la casa de una familia de pastores asentados a unos 20 km. al sur de Mina Pirquitas, utilizándose dicha casa, que simultáneamente nos sirvió de albergue, como base de nuestras operaciones. Trabajamos, también, en otros puestos de la misma familia, así como con familias vecinas. En este trabajo presentamos una síntesis interpretativa de datos sobre religiosidad de los pastores, obtenidos en un área del Altiplano Andino Meridional, que se encuentra ubicada en el NO de la provincia argentina de Jujuy, cerca de los límites con Chile y Bolivia. Dichos datos fueron recogidos en tres trabajos de campo, llevados a cabo en distintos periodos de los años 1977, 1978 y 1979. Los mismos tuvieron como escenario principal la casa de una familia de pastores asentados a unos 20 km. al sur de Mina Pirquitas, utilizándose dicha casa, que simultáneamente nos sirvió de albergue, como base de nuestras operaciones. Trabajamos, también, en otros puestos de la misma familia, así como con familias vecinas.
- Published
- 1983
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36. Electrophysiologic features in patients with chronic neurolathyrism.
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Drory, V. E., Rabey, M. J., and Cohn, D. F.
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- 1992
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37. Prevalence of nonmotor symptoms in Parkinson's disease in an international setting; study using nonmotor symptoms questionnaire in 545 patients
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Martinez Martin, P, Shapira, Ah, Stocchi, F, Sethi, K, Odin, P, Macphee, G, Brown, Rg, Naidu, Y, Clayton, L, Abe, K, Tsuboi Maamahon, D, Barone, P, Rabey, M, Bonuccelli, Ubaldo, Forbes, A, Breen, K, Tluk, S, Olanow, Cw, Thomas, S, Rye, D, Hand, A, Willias, Aj, Ondo, W, and Chanduri, Kr
38. Electrophysiologic features in patients with chronic neurolathyrism
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Drory, V. E., Rabey, M. J., and Cohn, D. F.
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- 2002
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39. Development and preliminary validation of the chronic pain acceptance questionnaire for clinicians
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Mark J. Catley, Martin Rabey, Damien Appleton, Kevin E. Vowles, Richard Bennett, James H. McAuley, Rabey, M, Catley, M, Vowles, K, Appleton, D, Bennett, R, and McAuley, J
- Subjects
medicine.medical_specialty ,Attitude of Health Personnel ,Intraclass correlation ,psychometric ,clinician ,Acceptance and commitment therapy ,03 medical and health sciences ,0302 clinical medicine ,Surveys and Questionnaires ,medicine ,Humans ,030212 general & internal medicine ,Rasch model ,business.industry ,Chronic pain ,Reproducibility of Results ,medicine.disease ,Test (assessment) ,Cross-Sectional Studies ,Anesthesiology and Pain Medicine ,Standard error ,Scale (social sciences) ,Cohort ,Physical therapy ,Neurology (clinical) ,Chronic Pain ,business ,chronic pain ,030217 neurology & neurosurgery ,acceptance - Abstract
Background and Aims Higher chronic pain acceptance is associated with lower pain and disability. Clinician beliefs are associated with patients’ beliefs. This study therefore aimed to develop the Chronic Pain Acceptance Questionnaire for Clinicians (CPAQ-C) to measure clinicians’ beliefs regarding the importance of levels of acceptance in patients with chronic pain, and to examine the questionnaire’s psychometric properties. Methods Phase one: the CPAQ-C was adapted from the Chronic Pain Acceptance Questionnaire. Data on 162 completed questionnaires were analysed using Rasch analysis. Phase Two: the cohort completed the Healthcare Providers Pain and Impairment Relationship Scale, and the association (Pearson’s correlation co-efficient) between these questionnaires examined to assist CPAQ-C validation. Twenty-four participants completed the CPAQ-C one-week later. Test re-test reliability was examined using intraclass correlation co-efficient (2,1) and standard error of measurement. Phase Three: to examine responsiveness 17 clinicians attending a workshop on Acceptance and Commitment Therapy completed the CPAQ-C before and immediately after the workshop, and six-months later. The Skillings Mack test was used to determine whether CPAQ-C scores differed across different timepoints. Results Rasch analysis supported two subscales: activity engagement and pain willingness. Five poorly functioning items were excluded. There was good correlation between the CPAQ-C and Healthcare Providers Pain and Impairment Relationship Scale (-.54). The CPAQ-C demonstrated good reliability (ICC (2,1): .81; standard error of measurement: 4.76). There was significant improvement in CPAQ-C scores following the workshop (p= Conclusions The CPAQ-C appears a valid, reliable and responsive measure of clinicians’ beliefs regarding the importance of levels of acceptance in patients with chronic pain. Implications Where the CPAQ-C reveals that clinicians have low perceived levels of importance regarding acceptance in patients with chronic pain those clinicians may benefit from specific education, however, this requires further examination.
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- 2020
40. Prevalence of nonmotor symptoms in Parkinson's disease in an international setting; Study using nonmotor symptoms questionnaire in 545 patients
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Kieran Breen, William G. Ondo, Dough MacMahon, Pablo Martinez-Martin, Yoshio Tsuboi, Lisa Clayton, Per Odin, Anthony H.V. Schapira, A Forbes, Kapil D. Sethi, Ubaldo Bonuccelli, Fabrizio Stocchi, Y. Naidu, Paolo Barone, K. Ray Chaudhuri, Adrian J. Williams, Richard G. Brown, S. Tluk, C. Warren Olanow, Graeme Macphee, Annette Hand, David B. Rye, Kazuo Abe, Martin Rabey, Sue Thomas, Martinez Martin, P, Schapira, Ah, Stocchi, F, Sethi, K, Odin, P, Macphee, G, Brown, Rg, Naidu, Y, Clayton, L, Abe, K, Tsuboi, Y, Macmahon, D, Barone, Paolo, Rabey, M, Bonuccelli, U, Forbes, A, Breen, K, Tluk, S, Olanow, Cw, Thomas, S, Rye, D, Hand, A, Williams, Aj, Ondo, W, and Chaudhuri, K. R.
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Adult ,Male ,medicine.medical_specialty ,Parkinson's disease ,Cross-sectional study ,International Cooperation ,MEDLINE ,Disease ,Statistics, Nonparametric ,Quality of life ,Surveys and Questionnaires ,Humans ,Medicine ,Depression (differential diagnoses) ,Aged ,Retrospective Studies ,Aged, 80 and over ,business.industry ,Parkinson Disease ,Retrospective cohort study ,Middle Aged ,medicine.disease ,Screening questionnaire ,Cross-Sectional Studies ,Neurology ,Physical therapy ,Feasibility Studies ,Female ,Neurology (clinical) ,business - Abstract
2006, there was, no single instrument (questionnaire or scale) for attempting a comprehensive assessment of the wide range of nonmotor symptoms (NMS) of Parkinson's disease (PD). The PD nonmotor group, a multidisciplinary group of experts including patient group representatives developed and validated the NMS screening questionnaire (NMSQuest) comprising 30 items. The NMSQuest is a self completed screening tool designed to draw attention to the presence of NMS. In this paper, we present the results gathered from 545 patients using the definitive version of the NMSQuest highlighting the prevalence of the wide range of NMS flagged in the NMSQuest from consecutive PD patients in an international setting.
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- 2007
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41. The metric properties of a novel non-motor symptoms scale for Parkinson's disease: Results from an international pilot study
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A Forbes, Warren Olanow, David B. Rye, Y. Naidu, Fabrizio Stocchi, Paolo Barone, Anthony H.V. Schapira, Pablo Martinez-Martin, Martin Rabey, William G. Ondo, Per Odin, Annette Hand, Richard G. Brown, Kazuo Abe, Yoshio Tsuboi, Graeme Macphee, Kallol Ray Chaudhuri, Sue Thomas, Adrian J. Williams, Kieran Breen, Doug MacMahon, S. Tluk, Kapil D. Sethi, Chaudhuri, Kr, Martinez Martin, P, Brown, Rg, Sethi, K, Stocchi, F, Odin, P, Ondo, W, Abe, K, Macphee, G, Macmahon, D, Barone, Paolo, Rabey, M, Forbes, A, Breen, K, Tluk, S, Naidu, Y, Olanow, W, Williams, Aj, Thomas, S, Rye, D, Tsuboi, Y, Hand, A, and Schapira, A. H.
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Adult ,Male ,medicine.medical_specialty ,Parkinson's disease ,Psychometrics ,Cross-sectional study ,Pilot Projects ,Scopa ,Comorbidity ,Neuropsychological Tests ,Disability Evaluation ,Quality of life ,medicine ,Humans ,Aged ,Aged, 80 and over ,Neurologic Examination ,Parkinson Disease ,Middle Aged ,medicine.disease ,Mood ,Cross-Sectional Studies ,Neurology ,Physical therapy ,Quality of Life ,Ceiling effect ,Female ,Neurology (clinical) ,Psychology - Abstract
Non-motor symptoms (NMS) in Parkinson's disease (PD) are common, significantly reduce quality of life and at present there is no validated clinical tool to assess the progress or potential response to treatment of NMS. A new 30-item scale for the assessment of NMS in PD (NMSS) was developed. NMSS contains nine dimensions: cardiovascular, sleep/fatigue, mood/cognition, perceptual problems, attention/memory, gastrointestinal, urinary, sexual function, and miscellany. The metric attributes of this instrument were analyzed. Data from 242 patients mean age 67.2 +/- 11 years, duration of disease 6.4 +/- 6 years, and 57.3% male across all stages of PD were collected from the centers in Europe, USA, and Japan. The mean NMSS score was 56.5 +/- 40.7, (range: 0-243) and only one declared no NMS. The scale provided 99.2% complete data for the analysis with the total score being free of floor and ceiling effect. Satisfactory scaling assumptions (multitrait scaling success rate >95% for all domains except miscellany) and internal consistency were reported for most of the domains (mean alpha, 0.61). Factor analysis supported the a prori nine domain structure (63% of the variance) while a small test-retest study showed satisfactory reproducibility (ICC > 0.80) for all domains except cardiovascular (ICC = 0.45). In terms of validity, the scale showed modest association with indicators of motor symptom severity and disease progression but a high correlation with other measures of NMS (NMSQuest) and health-related quality of life measure (PDQ-8) (both, rS = 0.70). In conclusion, NMSS can be used to assess the frequency and severity of NMS in PD patients across all stages in conjunction with the recently validated non-motor questionnaire.
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- 2007
42. Pain Catastrophizing, Beliefs and Perception, and Their Association With Profiling Characteristics in Athletes.
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Maestroni L, Rabey M, Mariani C, Villa V, Landi L, Rodi A, Civera F, Bettariga F, and Turner A
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Context: Variables associated with pain catastrophizing and beliefs in athletes presenting with musculoskeletal pain and/or sports-related injuries are largely unexplored., Objective: We aimed to evaluate which anthropometric, sociodemographic, sporting, injury history, and care-seeking characteristics were associated with the Pain Catastrophizing Scale (PCS) and Pain Beliefs and Perceptions Inventory (PBAPI) scores in athletes., Design: This study followed a cross-sectional design., Methods: Three hundred and twelve athletes (40% females) from different sports and levels completed a questionnaire including demographic information, details regarding sports practice, injury history, health care use, PCS, and PBAPI. Univariable associations between PCS and PBAPI scores and each variable were assessed using linear regression. Variables with univariable associations where P < .05 were entered into multivariable regression models., Results: The final multivariable model including gender, recurrent and persistent pain, a history of a severe atraumatic injury, and a history of more than 5 atraumatic injuries explained 14.9% of the variance in PBAPI scores. Performing a team sport and a history of more than 5 atraumatic injuries explained 5.1% of the variance in PCS scores., Conclusions: Gender, sporting, and injury history characteristics explained only a small portion of the variance in PCS and PBAPI scores, whereas having received healthcare support and the number of appointments did not. Most of the variance was left unexplained.
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- 2024
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43. Breaking the cycle of reoccurring low back pain with integrated motivational interviewing and cognitive behavioural therapy to facilitate education and exercise advice: a superiority randomised controlled trial study protocol.
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Watson ED, Marshall PW, Morrison NMV, Moloney N, O'Halloran P, Rabey M, Niazi IK, Stevens K, and Kingsley M
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- Adult, Humans, Male, Equivalence Trials as Topic, Exercise Therapy methods, Recurrence, Randomized Controlled Trials as Topic, Cognitive Behavioral Therapy methods, Low Back Pain therapy, Motivational Interviewing methods, Patient Education as Topic methods
- Abstract
Background: Non-specific low back pain is a common and costly global issue. Many people with low back pain live for years with ongoing symptom recurrence and disability, making it crucial to find effective prevention strategies. Motivational interviewing (MI) is an evidence-based patient-centred counselling style that helps motivate individuals to change their behaviours. In combination, MI and cognitive-behavioural therapy (MI-CBT) has the potential to yield long term improvements in pain and disability and reduce incidence of recurrence., Method: This is a two-arm superiority randomised controlled trial comparing MI-CBT and Education (n = 83) with Education only (n = 83). Participants that have recovered from a recent episode of non-specific low back pain (7th consecutive day with pain ≤ 2 on a 0-10 numeric pain rating scale) will be eligible for inclusion into the study. Both groups will receive five 30-min sessions over a 10-week period as well as the Navigating Pain booklet, homework book and a standardised exercise programme. In the intervention group, MI-CBT techniques will be used to provide individualised support, identify beliefs, and increase engagement with the resources provided. Outcomes measures include pain (current and in the last 7 days) as rated on the numeric pain rating scale. This will be used to determine recurrence (number of participants who report back pain ≥ 3 out of 10 on the numeric pain rating scale). Furthermore, self-reported (1) pain intensity; (2) pain catastrophizing; (3) fear-avoidance beliefs; (4) pain self-efficacy; (5) depression and anxiety; (6) disability will be measured. All outcomes will be measured at baseline, and again at 3-, 6-, and 12-months post allocation., Discussion: The effective delivery of self-management strategies to prevent recurrence of low back pain is an important aspect that requires urgent attention. This study will provide new information on the effectiveness of using an MI-CBT approach to facilitate self-management through education and exercise to improve low back pain outcomes. Evidence emerging from this trial has the potential to inform clinical practice and healthcare management of non-specific low back pain., Trial Registration: Prospectively registered with Australian New Zealand Clinical Trials Registry: ACTRN12623000746639 (10/07/2023)., (© 2024. The Author(s).)
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- 2024
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44. How do people with chronic low back pain pick a pencil off the floor?
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Kendell M, Smith A, O'Sullivan P, Beales D, Chan J, Li KM, McMullan M, Smith K, and Rabey M
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- Humans, Reproducibility of Results, Movement, Biomechanical Phenomena, Low Back Pain, Chronic Pain diagnosis
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Background: Picking objects off the floor is provocative for people with chronic low back pain (CLBP). There are no clinically applicable methods evaluating movement strategies for this task. The relationship between strategy and multidimensional profiles is unknown., Objective: Develop a movement evaluation tool (MET) to examine movement strategies in people with CLBP (n = 289) picking a pencil off the floor. Describe those movement strategies, and determine reliability of the MET. Explore differences across multidimensional profiles and movement strategies., Methods: An MET was developed using literature and iterative processes, and its inter-rater agreement determined. Latent class analysis (LCA) derived classes demonstrating different strategies using six movement parameters as indicator variables. Differences between classes across multidimensional profiles were investigated using analysis of variance, Kruskal-Wallis, or chi-squared tests., Results: Six movement parameters were evaluated. There was substantial inter-rater agreement (Cohen's Kappa = 0.39-0.79) across parameters. LCA derived three classes with different strategies: Class 1 (71.8%) intermediate trunk inclination/knee flexion; Class 2 (24.5%) greater forward trunk inclination, lower knee flexion; Class 3 (3.7%) lower forward trunk inclination, greater knee flexion. Pain duration differed across all classes (p ≤ .001). Time taken to complete forward bends differed between Class 3 and other classes (p = .024)., Conclusions: Movement strategies can be reliably assessed using the MET. Three strategies for picking lightweight objects off the floor were derived, which differed across pain duration and speed of movement.
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- 2024
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45. Societal beliefs about pain may be more balanced than previously thought. Results of the Guernsey pain survey.
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Rabey M, Slater H, Hebron C, and Moloney N
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- Humans, Female, Male, Guernsey, Surveys and Questionnaires, Neck Pain diagnosis, Neck Pain therapy, Musculoskeletal Pain diagnosis, Musculoskeletal Pain therapy, Chronic Pain diagnosis, Chronic Pain therapy, Chronic Pain psychology
- Abstract
Background: Musculoskeletal pain is multidimensional and associated with significant societal impact. Persistent or chronic pain is a public health priority. A step towards high-value care is a contemporary understanding of pain. While pain-related knowledge has been examined in specific conditions (e.g. neck pain) knowledge of the public's broader understanding regarding musculoskeletal pain per se, warrants investigation. This study examined the public's knowledge and beliefs regarding musculoskeletal pain and pain management., Methods: This observational cohort study was conducted in Guernsey (January 2019-February 2020). Participants (n = 1656; 76.0% female) completed an online questionnaire capturing: demographics, pain experience, work absenteeism, understanding of pain and pain management, multidimensional influences, physical activity, pain catastrophising and healthcare decision-making. Statements were deemed true/false/equivocal and mapped to biopsychosocial/biomedical/neutral perspectives based upon contemporary literature. Descriptive statistics were analysed for each statement. Participants' responses were examined for alignment to a contemporary viewpoint and themes within responses derived using a semi-quantitative approach modelled on direct content analysis. Comparisons between participants with/without pain were examined (χ
2 -squared/Wilcoxon Rank Sum test)., Results: Within the cohort 83.6% reported currently experiencing pain. The overarching theme was perspectives that reflected both biomedical and contemporary, multidimensional understandings of pain. Sub-themes included uncertainty about pain persistence and evidence-based means to reduce recurrence, and reliance upon healthcare professionals for guiding decision-making. Compared to those with pain, those without had a greater belief that psychological interventions may help and lower pain catastrophising., Conclusions: Participants' understanding of pain demonstrated both biomedical and multidimensional pain understanding consistent with elements of a contemporary understanding of pain., (© 2024. The Author(s).)- Published
- 2024
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46. When is a specialist not a specialist? Or can IFOMPT start a conversation?
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Rabey M
- Published
- 2023
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47. Validation of a Case Definition to Identify Patients Diagnosed With Cardiovascular Disease in Canadian Primary Care Practices.
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Thomas RD, Kosowan L, Rabey M, Bell A, Connelly KA, Hawkins NM, Casey CG, and Singer AG
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Background: Cardiovascular disease (CVD) is a leading cause of death globally. This study validates a primary care-based electronic medical record case definition for CVD., Methods: This retrospective, cross-sectional study explores electronic medical record data from 1574 primary care providers participating in the Canadian Primary Care Sentinel Surveillance Network. A reference standard was created by reviewing medical records of a subset of patients in this network (n = 2017) for coronary artery disease (CAD), cerebrovascular disease (CeVD), and peripheral vascular disease (PVD). Together, these data produced a CVD reference. We applied validated case definitions to an active patient population (≥ 1 visit between January 1, 2018 and December 31, 2019) to estimate prevalence using the exact binomial test (N = 689,301). Descriptive statistics, χ
2 tests, and t tests characterized patients with vs without CVD., Results: The optimal CVD Case Definition 2 had a sensitivity of 68.5% (95% Confidence Interval [CI]: 61.6%-74.8%), a specificity of 97.8% (95% CI: 97.0%-98.4%), a positive predictive value of 77.7% (95% CI: 71.6%-82.7%), and a negative predictive value of 96.5% (95% CI: 95.8%-97.1%). Included in this CVD definition was a strong CAD case definition with sensitivity of 91.6% (95% CI: 84.6%-96.1%), specificity of 98.3% (95% CI: 97.6%-98.8%), a PPV of 74.8% (95% CI: 67.8%-80.7%), and an NPV of 99.5% (95% CI: 99.1%-99.7%). This CVD definition also included CeVD and PVD case definitions with low sensitivity (77.6% and 36.6%) but high specificity (98.6% and 99.0%). The estimated prevalence of CVD among primary care patients is 11.2% (95% CI, 11.1%-11.3%; n = 77,064); the majority had CAD (6.4%)., Conclusions: This study validated a definition of CVD and its component parts-CAD, CeVD, and PVD. Understanding the prevalence and disease burden for patients with CVD within primary care settings can improve prevention and disease management., (© 2023 The Authors.)- Published
- 2023
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48. Interaction analyses: Enhancing understanding of chronic low back pain.
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Rabey M, Kendell M, Shea YL, Mattinson D, Koh YFN, Seow KC, and Beales D
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- Humans, Longitudinal Studies, Fear psychology, Exercise, Pain Measurement, Low Back Pain therapy, Low Back Pain psychology
- Abstract
Background: Chronic low back pain (CLBP) is complex. Statistical examination of influences of exposures (e.g. characteristics) upon outcomes (e.g. pain) facilitates understanding of complexity and personalized care. Psychological factors may be associated with higher disability following exercise in CLBP. Examining interactions of psychological variables with exercise on disability might further understanding of CLBP., Objectives: Secondary analysis of data from a CLBP cohort evaluating interactions between psychological variables and exercise on disability., Design: Longitudinal cohort study., Method: Variables from a published prognostic model for disability: disability (baseline/one-year follow-up), psychological principal component scores (principal component score two (PC2) - Fear-avoidance beliefs, pain catastrophizing, pain self-efficacy; principal component score three (PC3) - thought suppression, behavioral endurance), exercise (during follow-up), forward-bending time, punishing significant other responses. Differences between exercisers and non-exercisers were assessed using Chi-Squared/Mann-Whitney tests. Multivariable linear regression models for follow-up disability included a term examining interaction between principal component scores and exercise., Results: Exercisers had significantly different scores for PC2 (p = .02) and PC3 (p = .03), lower baseline (p = .005) and follow-up pain intensity (p < .001), follow-up disability (p < .001) and faster forward-bend times (p = .014). There was no significant interaction between exercise and PC2 (p = .92) or PC3 (p = .75)., Conclusions: This study showed no interaction between psychological factors and exercise on disability at follow-up. These findings suggest that the disability outcome of people with CLBP who undertake exercise as an intervention does not differ from those who do not undertake exercise, irrespective of their baseline psychological status., Competing Interests: Declaration of competing interest MR received the following funding for this research: Australian Postgraduate Award, Curtin University Postgraduate Scholarship, Musculoskeletal Association of Chartered Physiotherapists Doctoral Award, Chartered Society of Physiotherapists Charitable Trust. These sponsors had no role in this research. The other authors have no declarations of interest., (Copyright © 2023 Elsevier Ltd. All rights reserved.)
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- 2023
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49. Is low intensity exercise sufficient to induce exercise-induced pain threshold modulation in people with persistent pain?
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Moloney N, Rabey M, Hush J, Sanders D, Dube T, and Marcuzzi A
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- Humans, Cross-Sectional Studies, Pain Measurement, Exercise physiology, Hyperalgesia, Pain Threshold physiology, Pain
- Abstract
Objectives: We investigated whether a 12-min walk test (12MWT) yielded exercise-induced pain threshold modulation (EIPM) within people with persistent pain and whether baseline self-report and pain sensitivity measures differed according to these responses., Design: Cross-sectional study., Methods: Two cohorts (tertiary/community) (n = 88) with persistent pain underwent pressure pain threshold (PPT) testing before and after a 12MWT to determine exercise-induced pain threshold modulation responses. Baseline self-report (pain severity, pain distribution, psychological distress, sleep) and baseline widespread pain sensitivity (WPS) (high/low) were recorded. Within and between-group differences were analysed using paired t-tests and repeated measure analyses of covariance. Individual EIPM responses were categorised as hyperalgesic, no change and hypoalgesic responses. Differences in baseline self-report and pain sensitivity measures between EIPM categories were investigated., Results: No significant within- or between-group differences in PPT following the 12MWT were detected (p > 0.05). Individual responses showed that up to 30% of the community and 44% of the tertiary cohort demonstrated >20% change in PPT (in either direction). Significant differences were shown in pain distribution (p = 0.002) and baseline WPS (p = 0.001) between people with hyperalgesic, no change, hypoalgesic responses. People with 4-5 pain regions were more likely hyperalgesic (χ2 = 9.0, p = 0.003); people with low baseline WPS were more likely to demonstrate no change (p = 0.002)., Conclusion: Low or self-selected intensity exercise was insufficient to induce exercise-induced pain modulation at group level. Individual responses were variable with pain distribution and baseline WPS differing between responses. Future research could evaluate responses and associated factors in larger samples with high baseline pain sensitivity specifically., (Copyright © 2022 Elsevier Ltd. All rights reserved.)
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- 2022
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50. Effect of Graded Sensorimotor Retraining on Pain Intensity in Patients With Chronic Low Back Pain: A Randomized Clinical Trial.
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Bagg MK, Wand BM, Cashin AG, Lee H, Hübscher M, Stanton TR, O'Connell NE, O'Hagan ET, Rizzo RRN, Wewege MA, Rabey M, Goodall S, Saing S, Lo SN, Luomajoki H, Herbert RD, Maher CG, Moseley GL, and McAuley JH
- Subjects
- Adult, Exercise, Female, Humans, Male, Middle Aged, Minimal Clinically Important Difference, Neurological Rehabilitation methods, Pain Measurement, Treatment Outcome, Chronic Pain complications, Chronic Pain rehabilitation, Chronic Pain therapy, Low Back Pain complications, Low Back Pain rehabilitation, Low Back Pain therapy, Pain Management methods, Physical Therapy Modalities, Somatosensory Disorders etiology, Somatosensory Disorders rehabilitation, Somatosensory Disorders therapy
- Abstract
Importance: The effects of altered neural processing, defined as altering neural networks responsible for perceptions of pain and function, on chronic pain remains unclear., Objective: To estimate the effect of a graded sensorimotor retraining intervention (RESOLVE) on pain intensity in people with chronic low back pain., Design, Setting, and Participants: This parallel, 2-group, randomized clinical trial recruited participants with chronic (>3 months) nonspecific low back pain from primary care and community settings. A total of 276 adults were randomized (in a 1:1 ratio) to the intervention or sham procedure and attention control groups delivered by clinicians at a medical research institute in Sydney, Australia. The first participant was randomized on December 10, 2015, and the last was randomized on July 25, 2019. Follow-up was completed on February 3, 2020., Interventions: Participants randomized to the intervention group (n = 138) were asked to participate in 12 weekly clinical sessions and home training designed to educate them about and assist them with movement and physical activity while experiencing lower back pain. Participants randomized to the control group (n = 138) were asked to participate in 12 weekly clinical sessions and home training that required similar time as the intervention but did not focus on education, movement, and physical activity. The control group included sham laser and shortwave diathermy applied to the back and sham noninvasive brain stimulation., Main Outcomes and Measures: The primary outcome was pain intensity at 18 weeks, measured on an 11-point numerical rating scale (range, 0 [no pain] to 10 [worst pain imaginable]) for which the between-group minimum clinically important difference is 1.0 point., Results: Among 276 randomized patients (mean [SD] age, 46 [14.3] years; 138 [50%] women), 261 (95%) completed follow-up at 18 weeks. The mean pain intensity was 5.6 at baseline and 3.1 at 18 weeks in the intervention group and 5.8 at baseline and 4.0 at 18 weeks in the control group, with an estimated between-group mean difference at 18 weeks of -1.0 point ([95% CI, -1.5 to -0.4]; P = .001), favoring the intervention group., Conclusions and Relevance: In this randomized clinical trial conducted at a single center among patients with chronic low back pain, graded sensorimotor retraining, compared with a sham procedure and attention control, significantly improved pain intensity at 18 weeks. The improvements in pain intensity were small, and further research is needed to understand the generalizability of the findings., Trial Registration: ANZCTR Identifier: ACTRN12615000610538.
- Published
- 2022
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