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6 results on '"Rachlis, Elena"'

1. Treatment of Acute Myeloid Leukemia or Myelodysplastic Syndrome Relapse after Allogeneic Stem Cell Transplantation with Azacitidine and Donor Lymphocyte Infusions—A Retrospective Multicenter Analysis from the German Cooperative Transplant Study Group

Author

Schroeder, Thomas, Rachlis, Elena, Bug, Gesine, Stelljes, Matthias, Klein, Stefan, Steckel, Nina Kristin, Wolf, Dominik, Ringhoffer, Mark, Czibere, Akos, Nachtkamp, Kathrin, Dienst, Ariane, Kondakci, Mustafa, Stadler, Michael, Platzbecker, Uwe, Uharek, Lutz, Luft, Thomas, Fenk, Roland, Germing, Ulrich, Bornhäuser, Martin, Kröger, Nicolaus, Beelen, Dietrich W., Haas, Rainer, and Kobbe, Guido

Published
2015
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2. Relative Impact of HLA Matching and Non-HLA Donor Characteristics on Outcomes of Allogeneic Stem Cell Transplantation for Acute Myeloid Leukemia and Myelodysplastic Syndrome

Author

Ayuk, Francis, primary, Beelen, Dietrich W., additional, Bornhäuser, Martin, additional, Stelljes, Matthias, additional, Zabelina, Tatjana, additional, Finke, Jürgen, additional, Kobbe, Guido, additional, Wolff, Daniel, additional, Wagner, Eva-Maria, additional, Christopeit, Maximilian, additional, Schmid, Christoph, additional, Ottinger, Hellmut, additional, Groth, Christoph, additional, Faul, Christoph, additional, Bertz, Hartmut, additional, Rachlis, Elena, additional, Wolschke, Christine, additional, Schetelig, Johannes, additional, Horn, Peter A., additional, Mytilineos, Joannis, additional, Guellstorf, Martina, additional, Kelsch, Reinhard, additional, Fleischhauer, Katharina, additional, Kröger, Nicolaus, additional, and Bethge, Wolfgang, additional

Published
2018
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3. Impact of Donor-Recipient Histocompatibility and CMV-Mismatch on Outcome of Allogeneic Stem Cell Transplantation for AML and MDS: A Retrospective Registry Study of the German Stem Cell Transplant Registry (DRST) of the German Working Group for Blood and Marrow Transplantation (DAG-KBT)

Author

Ayuk, Francis A., primary, Beelen, Dietrich W., additional, Bornhäuser, Martin, additional, Stelljes, Matthias, additional, Zabelina, Tajana, additional, Finke, Jürgen, additional, Kobbe, Guido, additional, Wolff, Daniel, additional, Wagner, Eva Maria, additional, Christopeit, Maximilian, additional, Schmid, Christoph, additional, Ottinger, Hellmut, additional, Groth, Christoph, additional, Faul, Christoph, additional, Bertz, Hartmut, additional, Rachlis, Elena, additional, Wolschke, Christine, additional, Kröger, Nicolaus, additional, and Bethge, Wolfgang, additional

Published
2016
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4. Treatment of Acute Myeloid Leukemia or Myelodysplastic Syndrome Relapse after Allogeneic Stem Cell Transplantation with Azacitidine and Donor Lymphocyte Infusions—A Retrospective Multicenter Analysis from the German Cooperative Transplant Study Group

Author

Schroeder, Thomas, Rachlis, Elena, Bug, Gesine, Stelljes, Matthias, Klein, Stefan, Steckel, Nina Kristin, Wolf, Dominik, Ringhoffer, Mark, Czibere, Akos, Nachtkamp, Kathrin, Dienst, Ariane, Kondakci, Mustafa, Stadler, Michael, Platzbecker, Uwe, Uharek, Lutz, Luft, Thomas, Fenk, Roland, Germing, Ulrich, Bornhäuser, Martin, Kröger, Nicolaus, Beelen, Dietrich W., Haas, Rainer, and Kobbe, Guido

Abstract

To expand the current knowledge about azacitidine (Aza) and donor lymphocyte infusions (DLI) as salvage therapy for relapse after allogeneic hematopoietic stem cell transplantation (allo-HSCT) and to identify predictors for response and survival, we retrospectively analyzed data of 154 patients with acute myeloid leukemia (AML, n = 124), myelodysplastic (MDS, n = 28), or myeloproliferative syndrome (n = 2). All patients received a median number of 4 courses of Aza (range, 4 to 14) and DLI were administered to 105 patients (68%; median number of DLI, 2; range, 1 to 7). Complete and partial remission rates were 27% and 6%, respectively, resulting in an overall response rate of 33%. Multivariate analysis identified molecular-only relapse (hazard ratio [HR], 9.4; 95% confidence interval [CI], 2.0 to 43.5; P = .004) and diagnosis of MDS (HR, 4.1; 95% CI, 1.4 to 12.2; P = .011) as predictors for complete remission. Overall survival (OS) at 2 years was 29% ± 4%. Molecular-only relapse (HR, .14; 95% CI, .03 to .59; P = .007), diagnosis of MDS (HR, .33; 95% CI, .16 to .67; P = .002), and bone marrow blasts <13% (HR, .54; 95% CI, .32 to .91; P = .021) were associated with better OS. Accordingly, 2-year OS rate was higher in MDS patients (66% ± 10%, P = .001) and correlated with disease burden in patients with AML. In summary, Aza and DLI is an effective and well-tolerated treatment option for patients with relapse after allo-HSCT, in particular those with MDS or AML and low disease burden. The latter finding emphasizes the importance of stringent disease monitoring and early intervention.

Published
2024
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5. Monitoring of Wilms’ Tumor 1 (WT1) Expression in Peripheral Blood (PB) of Patients with Myelodysplastic Syndromes (MDS) By a Standardized European Leukemia Net (ELN)-Certified Assay to Detect Minimal Residual Disease (MRD) and Guide Therapeutic Interventions Following Allogeneic Transplantation

Author

Schroeder, Thomas, primary, Pechtel, Sabrina, additional, Lamers, Marius, additional, Dienst, Ariane, additional, Schuler, Esther, additional, Rachlis, Elena, additional, Wegener, Nadija, additional, Kündgen, Andrea, additional, Kondakci, Mustafa, additional, Fenk, Roland, additional, Gattermann, Norbert, additional, Haas, Rainer, additional, Germing, Ulrich, additional, and Kobbe, Guido, additional

Published
2014
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6. Azacitidine and Donor Lymphocyte Infusions As Treatment For Relapse After Allogeneic Stem Cell Transplantation - a Retrospective Multicenter Analysis In 115 Patients On Behalf Of The German Cooperative Transplant Study Group

Author

Schroeder, Thomas, primary, Rachlis, Elena, additional, Bug, Gesine, additional, Stelljes, Matthias, additional, Klein, Stefan A., additional, Wolf, Dominik, additional, Ringhoffer, Mark, additional, Czibere, Akos G., additional, Nachtkamp, Kathrin, additional, Dienst, Ariane, additional, Kondakci, Mustafa, additional, Stadler, Michael, additional, Platzbecker, Uwe, additional, Uharek, Lutz, additional, Luft, Thomas, additional, Fenk, Roland, additional, Germing, Ulrich, additional, Bornhäuser, Martin, additional, Kröger, Nicolaus, additional, Haas, Rainer, additional, and Kobbe, Guido, additional

Published
2013
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