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15 results on '"Rack, Kathrin"'

2. Assessment of effective mitigation and prediction of the spread of SARS-CoV-2 in Germany using demographic information and spatial resolution

Author

Kühn, Martin J., Abele, Daniel, Mitra, Tanmay, Koslow, Wadim, Abedi, Majid, Rack, Kathrin, Siggel, Martin, Khailaie, Sahamoddin, Klitz, Margrit, Binder, Sebastian, Spataro, Luca, Gilg, Jonas, Kleinert, Jan, Häberle, Matthias, Plötzke, Lena, Spinner, Christoph D., Stecher, Melanie, Zhu, Xiao Xiang, Basermann, Achim, and Meyer-Hermann, Michael

Published
2021
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6. MEmilio - a high performance Modular EpideMIcs simuLatIOn software

Author

Kühn, Martin Joachim, Abele, Daniel, Kerkmann, David, Korf, Sascha Alexander, Zunker, Henrik, Wendler, Anna Clara, Bicker, Julia, Nguyen, Dang Khoa, Klitz, Margrit, Koslow, Wadim, Siggel, Martin, Kleinert, Jan, Rack, Kathrin, Binder, Sebastian, Plötzke, Lena, Schmieding, René, Lenz, Patrick, Betz, Maximilian Franz, Lutz, Annette, Gerstein, Carlotta, Schmidt, Agatha, Meyer-Hermann, Michael, and Basermann, Achim

Subjects
Sars-CoV-2, Epidemiology, Pandemic Preparedness, High Performance Computing, Mathematical modeling, Computer simulation, Epidemics, Covid-19, Computer science, Virus
Published
2022

8. Regional opening strategies with commuter testing and containment of new SARS-CoV-2 variants in Germany

Author

Kühn, Martin J., primary, Abele, Daniel, additional, Binder, Sebastian, additional, Rack, Kathrin, additional, Klitz, Margrit, additional, Kleinert, Jan, additional, Gilg, Jonas, additional, Spataro, Luca, additional, Koslow, Wadim, additional, Siggel, Martin, additional, Meyer-Hermann, Michael, additional, and Basermann, Achim, additional

Published
2021
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9. Assessment of effective mitigation and prediction of the spread of SARS-CoV-2 in Germany using demographic information and spatial resolution

Author

Kühn, Martin J., primary, Abele, Daniel, additional, Mitra, Tanmay, additional, Koslow, Wadim, additional, Abedi, Majid, additional, Rack, Kathrin, additional, Siggel, Martin, additional, Khailaie, Sahamoddin, additional, Klitz, Margrit, additional, Binder, Sebastian, additional, Spataro, Luca, additional, Gilg, Jonas, additional, Kleinert, Jan, additional, Häberle, Matthias, additional, Plötzke, Lena, additional, Spinner, Christoph D., additional, Stecher, Melanie, additional, Zhu, Xiao Xiang, additional, Basermann, Achim, additional, and Meyer-Hermann, Michael, additional

Published
2020
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11. Margination and stretching of von Willebrand factor in the blood stream enable adhesion

Author

Rack, Kathrin, Huck, Volker, Hoore, Masoud, Fedosov, Dmitry A., Schneider, Stefan W., and Gompper, Gerhard

Subjects
congenital, hereditary, and neonatal diseases and abnormalities, Blood Cells, Movement, Computational science, lcsh:R, lcsh:Medicine, Models, Biological, Article, Biomechanical Phenomena, Computational biophysics, HEK293 Cells, Fluid dynamics, Lab-On-A-Chip Devices, hemic and lymphatic diseases, von Willebrand Factor, ddc:000, Cell Adhesion, cardiovascular system, Humans, lcsh:Q, Stress, Mechanical, lcsh:Science, Biological physics, Mechanical Phenomena, circulatory and respiratory physiology
Abstract

The protein von Willebrand factor (VWF) is essential in primary hemostasis, as it mediates platelet adhesion to vessel walls. VWF retains its compact (globule-like) shape in equilibrium due to internal molecular associations, but is able to stretch when a high enough shear stress is applied. Even though the shear-flow sensitivity of VWF conformation is well accepted, the behavior of VWF under realistic blood flow conditions remains poorly understood. We perform mesoscopic numerical simulations together with microfluidic experiments in order to characterize VWF behavior in blood flow for a wide range of flow-rate and hematocrit conditions. In particular, our results demonstrate that the compact shape of VWF is important for its migration (or margination) toward vessel walls and that VWF stretches primarily in a near-wall region in blood flow making its adhesion possible. Our results show that VWF is a highly optimized protein in terms of its size and internal associations which are necessary to achieve its vital function. A better understanding of the relevant mechanisms for VWF behavior in microcirculation provides a further step toward the elucidation of the role of mutations in various VWF-related diseases.

Published
2017
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12. BACARDI: A System to track Space Debris

Author

Stoffers, Martin, Meinel, Michael, Weigel, Martin, Siggel, Martin, Fiedler, Hauke, Rack, Kathrin, and Wasser, Yi

Subjects
Verteilte Systeme und Komponentensoftware, Institut für Simulations- und Softwaretechnik, space situational awareness, space debris, orbit database, Raumflugbetrieb und Astronautentraining, ComputerApplications_COMPUTERSINOTHERSYSTEMS, Astronautentraining, workflow system
Abstract

We present the "Backbone Catalogue of Relational Debris Information" (BACARDI) as an effort of the German Aerospace Center (DLR) to keep track of cooperative and uncooperative orbital objects. Key features of BACARDI are a database storing information about all known orbital objects, and a set of processing services that produce orbit information and different products like collision warnings.

Published
2019

13. SMARTnet™ and BACARDI

Author

Fiedler, Hauke, Herzog, Johannes, Hofmann, Benjamin, Kahle, Ralph, Meinel, Michael, Prohaska, Marcel, Rack, Kathrin, Schildknecht, Thomas, Siggel, Martin, Stoffers, Martin, Kurnatowski, Lynn, Wasser, Yi, and Weigel, Martin

Subjects
SMARTnet, BACARDI, Space Debris
Published
2019

15. Steering the Clinical Translation of Delivery Systems for Drugs and Health Products.

Author

Pignatello, Rosario, Matricardi, Pietro, Magni, Paolo, Pappalardo, Francesco, Russo, Giulia, Rack, Kathrin, Hoore, Masoud, Gompper, Gerhard, Fedosov, Dmitry A., Pannuzzo, Martina, Horta, Bruno A.C., Primavera, Rosita, Francesco, Martina Di, Rosa, Carmelo La, Moghimi, Seyed Moein, Decuzzi, Paolo, Rusciano, Dario, Brown, Marc B., Alvarez-Lorenzo, Carmen, and Camussi, Giovanni

Subjects
DRUG delivery systems, MEDICATION safety, CONTROLLED release drugs, HEALTH products, TRANSLATIONAL research, MEDICAL equipment
Abstract

Besides the feasibility for industrial scale-up, accelerating the translation from bench to bedside of new technological strategies for controlled delivery and targeting of drugs and other actives relevant for health management, such as medical devices and nutraceuticals, would benefit from an even earlier evaluation in pre-clinical models and clinical settings. At the same time, translational medicine also performs in the opposite direction, incorporating clinical needs and observations into scientific hypotheses and innovative technological proposals. With these aims, the sessions proposed for the 2019 CRS Italy Chapter Workshop will introduce the experience of Italian and worldwide researchers on how to foster the actual work in controlled release and drug delivery towards a reliable pre-clinical and clinical assessment. [ABSTRACT FROM AUTHOR]

Published
2020
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