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176 results on '"Radford, T."'

5. Australian experience with total pancreatectomy with islet autotransplantation to treat chronic pancreatitis

Author

Bampton, TJ, Holmes-Walker, DJ, Drogemuller, CJ, Radford, T, Anderson, P, Etherton, C, Russell, CH, Khurana, S, Torpy, DJ, Couper, JJ, Couper, RLT, Macintyre, P, Neo, EL, Benitez-Aguirre, P, Thomas, G, Loudovaris, T, Thomas, HE, Palmer, LJ, Wu, D, Rogers, NM, Williams, L, Hawthorne, WJ, O'Connell, PJ, Kay, TW, Pleass, H, Chen, JW, Coates, PT, Bampton, TJ, Holmes-Walker, DJ, Drogemuller, CJ, Radford, T, Anderson, P, Etherton, C, Russell, CH, Khurana, S, Torpy, DJ, Couper, JJ, Couper, RLT, Macintyre, P, Neo, EL, Benitez-Aguirre, P, Thomas, G, Loudovaris, T, Thomas, HE, Palmer, LJ, Wu, D, Rogers, NM, Williams, L, Hawthorne, WJ, O'Connell, PJ, Kay, TW, Pleass, H, Chen, JW, and Coates, PT

Abstract

BACKGROUND: This study aimed to describe the clinical outcomes of total pancreatectomy with islet autotransplantation (TP-IAT) in Australia. METHODS: Individuals selected for TP-IAT surgery according to the Minnesota Criteria (Appendix) without evidence of diabetes were evaluated including time to transplantation from pancreatectomy, islet numbers infused and post-transplantation HbA1c, C-peptide, total daily insulin and analgesic requirement. RESULTS: Sixteen individuals underwent TP-IAT from Australia and New Zealand between 2010 and 2020. Two recipients are deceased. The median islet equivalents/kg infused was 4244 (interquartile range (IQR) 2290-7300). The median C-peptide 1 month post-TP-IAT was 384 (IQR 210-579) pmol/L and at median 29.5 (IQR 14.5-46.5) months from transplant was 395 (IQR 139-862) pmol/L. Insulin independence was achieved in eight of 15 (53.3%) surviving recipients. A higher islet equivalents transplanted was most strongly associated with the likelihood of insulin independence (P < 0.05). Of the 15 surviving recipients, 14 demonstrated substantial reduction in analgesic requirement. CONCLUSION: The TP-IAT programme in Australia has been a successful new therapy for the management of individuals with chronic pancreatitis including hereditary forms refractory to medical treatment to improve pain management with 50% insulin independence rates.

Published
2021

8. Australia and New Zealand Islet and Pancreas Transplant Registry Annual Report 2018-Islet Donations, Islet Isolations, and Islet Transplants

Author

Webster, AC, Hedley, JA, Anderson, PF, Hawthorne, WJ, Radford, T, Drogemuller, C, Rogers, N, Goodman, D, Lee, MH, Loudovaris, T, Kelly, PJ, O'Connell, PJ, Holmes-Walker, DJ, Kay, TW, MacIsaac, RJ, Ward, GM, Howe, MK, Coates, PT, Torpy, D, Roberts, A, Russell, C, Olakkengil, S, Webster, AC, Hedley, JA, Anderson, PF, Hawthorne, WJ, Radford, T, Drogemuller, C, Rogers, N, Goodman, D, Lee, MH, Loudovaris, T, Kelly, PJ, O'Connell, PJ, Holmes-Walker, DJ, Kay, TW, MacIsaac, RJ, Ward, GM, Howe, MK, Coates, PT, Torpy, D, Roberts, A, Russell, C, and Olakkengil, S

Abstract

BACKGROUND: This is an excerpt from chapter 4 of the annual registry report from the Australia and New Zealand islet and pancreas transplant registry. The full report is available at http://anziptr.org/reports/. METHODS: We report data for all allogeneic islet isolation and transplant activity from 2002 to end 2017. Solid organ pancreas transplantation activity is reported separately. New Zealand does not have an islet transplant program. Data analysis was performed using Stata software version 14 (StataCorp, College Station, TX). RESULTS: From 2002 to 2017, a total of 104 allogeneic islet transplants were performed in 62 recipients. CONCLUSIONS: The number of islet transplants performed in Australia was slightly lower in 2017 but continues to increase over time.

Published
2019

14. Space traveller to see stars born 13bn years ago

Author

Radford, T

Subjects
General Physics Research
Abstract

British scientists are working on the James Webb telescope, successor to tje Hubble space telescope. A supersensitive camera called Miri - mid infrared instrument - being built by an international team, will be a key part of the European and American instrument (1 page)

Published
2004

19. 60m pounds research funds to boost technical science

Author

Radford, T

Subjects
Science Policy
Abstract

A 60m science research package was announced yesterday by the trade and industry secretary, Patricia Hewitt.The extra money comes from the chancellor's spending review. It will accelerate growth in science spending from 7% to 10% a year in real terms, and take the total budget to pounds 2.9bn by 2005-06 (1 page).

Published
2002

20. 'God' particle proves elusive

Author

Radford, T

Subjects
Physics::Popular Physics, Particle Physics - Research, High Energy Physics::Phenomenology, Computer Science::Programming Languages, High Energy Physics::Experiment, Nuclear Experiment
Abstract

For more than a decade, scientists at CERN have been hoping that a key theoretical particle called the Higgs boson, would turn up in a subatomic collision. Some of them are now though beginning to wonder if it has ever existed.

Published
2001

21. End of the world is nigh, scientists insist

Author

Radford, T

Subjects
General Physics Research
Abstract

Delegates at the British Association Festival of Science were presented with a number of doomsday scenarios. Quantum fluctuations, strangelets and asteroids were all described as having the potential to destroy the world, even the universe (2 pages).

Published
2001

23. Key sciences gain 250m pounds investment

Author

Radford, T

Subjects
Science Policy
Abstract

The government is to pump money into three key scientific fields on which it believes tomorrow's industrial empires will be built.

Published
2000

31. Islet Cell Transplantation in Australia: Screening, Remote Transplantation, and Incretin Hormone Secretion in Insulin Independent Patients.

Author

Marathe, C. S., Drogemuller, C. J., Marathe, J. A., Loudavaris, T., Hawthorne, W. J., O'Connell, P. J., Radford, T., Kay, T. W. H., Horowitz, M., Coates, P. T., and Torpy, D. J.

Subjects
ISLANDS of Langerhans transplantation, INCRETINS, INSULIN therapy, MEDICAL screening
Abstract

Islet cell transplantation has emerged as a treatment modality for type 1 diabetes in the last 15 years due to the Edmonton protocol leading to consistent and sustained exogenous insulin independence post-transplantation. In recent years, consortia that involve both local and remote islet cell centers have been established, with local centers responsible for processing and shipping of islet cells, and remote centers only transplanting them. There are, however, few data on patient outcomes at remote centers. A tendency for high fasting glucose despite insulin independence was noted by us and others with an unknown mechanism. This review provides a brief history of islet cell transplantation, and focuses on the South Australian remote center experience: the challenges, screening criteria, and the impact on incretin hormone secretion of insulin independent transplant patients. [ABSTRACT FROM AUTHOR]

Published
2015
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33. The acid catalyzed cyclization of citral

Author

Clark, B.C., Powell, C.C., and Radford, T.

Abstract

Fourteen compounds have been identified as products of the acid catalyzed cyclization of citral under mild aqueous acid conditions. Three major products of the reaction, 1,8-epoxy-p-menth-2-ene (11) and trans- and cis-p-menth-2-ene-1,8-diol (16and 18) are reported here for the first time as products from citral. Possible mechanistic pathways leading to the products are discussed.

Published
1977
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