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1. Lower serum levels of zinc and magnesium are associated with worse oral cGVHD and dysgeusia in cGVHD patients

Author

Mravak-Stipetić, Marinka, Radman, Maria, Desnica, Lana, Sabol, Ivan, Serventi-Seiwerth, Ranka, Perić, Zinaida, Duraković, Nadira, Ljubas Kelečić, Dina, Bilić, Ervina, Čeović, Romana, Karas, Irena, Vukić, Tamara, Samardžić, Antonela, Kerep Zelić, Ana, Katić, Mašenjka, Vrhovac, Radovan, Pavletić, Steven Živko, and Pulanić, Drazen

Subjects
immune system diseases, hemic and lymphatic diseases, oral cGVHD, zinc, magnesium
Abstract

Lower serum levels of zinc and magnesium are associated with worse oral cGVHD and dysgeusia in cGVHD patients

Published
2019

3. Oral cancer

Author

Radman, Maria and Mravak-Stipetić, Marinka

Subjects
prevencija, oralni pregled, prevention, screening, usna šupljina, probir, oral cavity, BIOMEDICINE AND HEALTHCARE. Dental Medicine. Oral Medicine, oral cancer, oral assessment, BIOMEDICINA I ZDRAVSTVO. Dentalna medicina. Oralna medicina, oralni karcinom
Abstract

Rak usne šupljine spada među 10 najčešćih neoplazmi i prema podacima SZO u svijetu su 2012. godine registrirana 300.373 nova slučaja oralnog karcinoma, a umrle su 145.353 osobe. Glavni rizični čimbenici za nastanak oralnog karcinoma su duhan i alkohol što objašnjava i veću pojavnost bolesti među muškarcima. U novije vrijeme infekcija s humanim papiloma virusom postaje važan etiološki čimbenik što uz promjenu stila života i prihvaćanje štetnih navika mijenja trendove učestalosti oralnog karcinoma i obolijeva sve više žena i mladih ljudi. Pojavi oralnog karcinoma obično prethode prekancerozna oštećenja oralne sluznice koja se, ako se rano otkriju, mogu uspješno liječiti. Zbog toga postoji potreba za učinkovitim metodama rane detekcije raka usne šupljine i lezija koje mu prethode. Ključnu ulogu u ranom otkrivanju raka usne šupljine imaju doktori dentalne medicine tijekom rutinskih stomatoloških pregleda ili u okviru programa probira. Edukacija studenata dentalne medicine kao i redoviti programi kontinuirane edukacije doktora dentalne medicine i drugih zdravstvenih djelatnih uključenih u brigu o oralnom zdravlju ključ su uspješne prevencije i ranog otkrivanja raka usne šupljine. Oral cancer (OC) is one of the 10th most common neoplasms globally and according to WHO Cancer Register there were an estimated 300.373 new cases diagnosed and 145.353 deaths recorded in 2012. The major recognized risk factors include smoking and alcohol what is possible explanation for higher incidence among men. Recently, oral human papilloma virus infection emerged as important etiological factor contributing together with life style changes and adoption of harmful habits to general trend for increasing incidence of OC among women and young persons. In spite of diagnostic and therapeutic development in OC patients’ mortality and morbidity rates remain high with no advancement in last 30 years. Most oral cancers develop from precancerous lesion of oral cavity mucosa and early detection is crucial for successful treatment. The doctors of dental medicine play key role in the early detection of oral cancer doing regular inspection of the oral mucosa to all their patients during routine examination or in screening programs. Appropriate education of dental medicine students and continuing education programs of general dentists are needed to increase successful prevention and early detection of oral cancer.

Published
2017

4. Znanje studenata četvrte i pete godine studija dentalne medicine o raku usne šupljine.

Author

Radman, Maria, Glavina, Ana, Sabol, Ivan, and Mravak-Stipetić, Marinka

Subjects
DENTAL students, DENTAL therapeutics, ADOLESCENT smoking, CANCER education, LEUKOPLAKIA, STUDY skills
Abstract

Copyright of Acta Stomatologica Croatica is the property of Acta Stomatologica Croatica and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2018
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5. Targeting Tumor-Associated Sialic Acids Using Chimeric Switch Receptors Based on Siglec-9 Enhances the Antitumor Efficacy of Engineered T Cells.

Author

Eisenberg V, Hoogi S, Katzman E, Ben Haim N, Zur-Toledano R, Radman M, Reboh Y, Zadok O, Kamer I, Bar J, Sagi I, Hendel A, and Cohen CJ

Subjects
Humans, Animals, Mice, Sialic Acids metabolism, Antigens, CD metabolism, Cell Line, Tumor, Xenograft Model Antitumor Assays, Neoplasms immunology, Neoplasms therapy, Neoplasms metabolism, Receptors, Chimeric Antigen immunology, Receptors, Chimeric Antigen metabolism, Receptors, Chimeric Antigen genetics, CRISPR-Cas Systems, Tumor Microenvironment immunology, Sialic Acid Binding Immunoglobulin-like Lectins metabolism, T-Lymphocytes immunology, T-Lymphocytes metabolism
Abstract

Cancer exploits different mechanisms to escape T-cell immunosurveillance, including overexpression of checkpoint ligands, secretion of immunosuppressive molecules, and aberrant glycosylation. Herein, we report that IFNγ, a potent immunomodulator secreted in the tumor microenvironment, can induce α2,6 hypersialylation in cancer cell lines derived from various histologies. We focused on Siglec-9, a receptor for sialic acid moieties, and demonstrated that the Siglec-9+ T-cell population displayed reduced effector function. We speculated that Siglec-9 in primary human T cells can act as a checkpoint molecule and demonstrated that knocking out Siglec-9 using a clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 system enhanced the functionality of primary human T cells. Finally, we aimed to augment cancer-specific T-cell activity by taking advantage of tumor hypersialylation. Thus, we designed several Siglec-9-based chimeric switch receptors (CSR), which included an intracellular moiety derived from costimulatory molecules (CD28/41BB) and different hinge regions. In an antigen-specific context, T cells transduced with Siglec-9 CSRs demonstrated increased cytokine secretions and upregulation of activation markers. Moreover, T cells equipped with specific Siglec-9 CSRs mediated robust antitumor activity in a xenograft model of human tumors. Overall, this work sheds light on tumor evasion mechanisms mediated by sialylated residues and exemplifies an approach to improve engineered T cell-based cancer treatment. See related Spotlight by Abken, p. 1310., (©2024 American Association for Cancer Research.)

Published
2024
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