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686 results on '"Raebel, Marsha"'

1. Distributed Regression Analysis Application in Large Distributed Data Networks: Analysis of Precision and Operational Performance

Author

Her, Qoua, Malenfant, Jessica, Zhang, Zilu, Vilk, Yury, Young, Jessica, Tabano, David, Hamilton, Jack, Johnson, Ron, Raebel, Marsha, Boudreau, Denise, and Toh, Sengwee

Subjects
Computer applications to medicine. Medical informatics, R858-859.7
Abstract

BackgroundA distributed data network approach combined with distributed regression analysis (DRA) can reduce the risk of disclosing sensitive individual and institutional information in multicenter studies. However, software that facilitates large-scale and efficient implementation of DRA is limited. ObjectiveThis study aimed to assess the precision and operational performance of a DRA application comprising a SAS-based DRA package and a file transfer workflow developed within the open-source distributed networking software PopMedNet in a horizontally partitioned distributed data network. MethodsWe executed the SAS-based DRA package to perform distributed linear, logistic, and Cox proportional hazards regression analysis on a real-world test case with 3 data partners. We used PopMedNet to iteratively and automatically transfer highly summarized information between the data partners and the analysis center. We compared the DRA results with the results from standard SAS procedures executed on the pooled individual-level dataset to evaluate the precision of the SAS-based DRA package. We computed the execution time of each step in the workflow to evaluate the operational performance of the PopMedNet-driven file transfer workflow. ResultsAll DRA results were precise (

Published
2020
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2. Outcome identification in electronic health records using predictions from an enriched Dirichlet process mixture

Author

Zeldow, Bret, Flory, James, Stephens-Shields, Alisa, Raebel, Marsha, and Roy, Jason

Subjects
Statistics - Methodology
Abstract

We propose a novel semiparametric model for the joint distribution of a continuous longitudinal outcome and the baseline covariates using an enriched Dirichlet process (EDP) prior. This joint model decomposes into a linear mixed model for the outcome given the covariates and marginals for the covariates. The nonparametric EDP prior is placed on the regression and spline coefficients, the error variance, and the parameters governing the predictor space. We predict the outcome at unobserved time points for subjects with data at other time points as well as for new subjects with only baseline covariates. We find improved prediction over mixed models with Dirichlet process (DP) priors when there are a large number of covariates. Our method is demonstrated with electronic health records consisting of initiators of second generation antipsychotic medications, which are known to increase the risk of diabetes. We use our model to predict laboratory values indicative of diabetes for each individual and assess incidence of suspected diabetes from the predicted dataset. Our model also serves as a functional clustering algorithm in which subjects are clustered into groups with similar longitudinal trajectories of the outcome over time.

Published
2018

3. Near Real-time Surveillance for Consequences of Health Policies Using Sequential Analysis

Author

Lu, Christine Y., Penfold, Robert B., Toh, Sengwee, Sturtevant, Jessica L., Madden, Jeanne M., Simon, Gregory, Ahmedani, Brian K., Clarke, Gregory, Coleman, Karen J., Copeland, Laurel A., Daida, Yihe G., Davis, Robert L., Hunkeler, Enid M., Owen-Smith, Ashli, Raebel, Marsha A., Rossom, Rebecca, Soumerai, Stephen B., and Kulldorff, Martin

Published
2018

4. Factors Associated With Prevalence and Treatment of Primary Biliary Cholangitis in United States Health Systems

Author

Everline, Rene, Daar, Zahra S., Melkonian, Christina, Zhang, Talan, Zhou, Yueren, Wu, Hank, Larkin, Dana, Islam, Nishat, Akkerman, Nonna, Trudeau, Sheri, Kohnhorst, Diane, Shaw, Sally F., Chiu, Vicki, Donald, Judy, Turner, Michelle, Rubenstein, Kevin, Redd, Jacquelyn, Wong, Carmen, Mor, Joanne, Bow, Kathy, Pieper, Lisa E., Anderson, Heather, Tesch, Nathan, Trimble, Solomon, De Los Santos, Mario J., III, Amlin, Tina, Khan, Shamyal, Dunlap, Kevin, Lu, Mei, Li, Jia, Haller, Irina V., Romanelli, Robert J., VanWormer, Jeffrey J., Rodriguez, Carla V., Raebel, Marsha A., Boscarino, Joseph A., Schmidt, Mark A., Daida, Yihe G., Sahota, Amandeep, Vincent, Jennifer, Bowlus, Christopher L., Lindor, Keith, Rupp, Loralee B., and Gordon, Stuart C.

Published
2018
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5. Identifying Preanalytic and Postanalytic Laboratory Quality Gaps Using a Data Warehouse and Structured Multidisciplinary Process

Author

Raebel, Marsha A., Quintana, LeeAnn M., Schroeder, Emily B., Shetterly, Susan M., Pieper, Lisa E., Epner, Paul L., Bechtel, Laura K., Smith, David H., Sterrett, Andrew T., Chorny, Joseph A., and Lubin, Ira M.

Subjects
Warehouse stores -- Quality management, Evidence-based medicine -- Analysis, Patient care -- Analysis, Drugstores, Pharmacy, Aspartate, Quality control, Blood tests, Complete blood count, Health care information services, Creatinine tests, Health
Abstract

Context.--The laboratory total testing process includes preanalytic, analytic, and postanalytic phases, but most laboratory quality improvement efforts address the analytic phase. Expanding quality improvement to preanalytic and postanalytic phases via use of medical data warehouses, repositories that include clinical, utilization, and administrative data, can improve patient care by ensuring appropriate test utilization. Cross-department, multidisciplinary collaboration to address gaps and improve patient and system outcomes is beneficial. Objective.--To demonstrate medical data warehouse utility for characterizing laboratory-associated quality gaps amenable to preanalytic or postanalytic interventions. Design.--A multidisciplinary team identified quality gaps. Medical data warehouse data were queried to characterize gaps. Organizational leaders were interviewed about quality improvement priorities. A decision aid with elements including national guidelines, local and national importance, and measurable outcomes was completed for each gap. Results.--Gaps identified included (1) test ordering; (2) diagnosis, detection, and documentation, and (3) high-risk medication monitoring. After examination of medical data warehouse data including enrollment, diagnoses, laboratory, pharmacy, and procedures for baseline performance, high-risk medication monitoring was selected, specifically alanine aminotransferase, aspartate aminotransferase, complete blood count, and creatinine testing among patients receiving disease-modifying antirheumatic drugs. The test utilization gap was in monitoring timeliness (eg, >60% of patients had a monitoring gap exceeding the guideline recommended frequency). Other contributors to selecting this gap were organizational enthusiasm, regulatory labeling, and feasibility of a significant laboratory role in addressing the gap. Conclusions.--A multidisciplinary process facilitated identification and selection of a laboratory medicine quality gap. Medical data warehouse data were instrumental in characterizing gaps. (Arch Pathol Lab Med. 2019;143:518-524; doi: 10.5858/arpa.2018-0093-OA), The complete laboratory testing process includes preanalytic (eg, test selection, ordering, and specimen collection), analytic (eg, specimen analysis), and postanalytic (eg, result reporting) components. (1) Laboratory quality improvement (QI) efforts [...]

Published
2019
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7. Increased Use of Second-Generation Macrolide Antibiotics for Children in Nine Health Plans in the United States

Author

Stille, Christopher J, Andrade, Susan E, Huang, Susan S, Nordin, James, Raebel, Marsha A, Go, Alan S, Chan, K Arnold, and Finkelstein, Jonathan A

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Antimicrobial Resistance, Infectious Diseases, Clinical Research, Vaccine Related, Pediatric, Infection, Good Health and Well Being, Adolescent, Anti-Bacterial Agents, Child, Child, Preschool, Drug Utilization, Female, Humans, Infant, Macrolides, Male, Managed Care Programs, Practice Patterns, Physicians', United States, antibiotics, macrolides, respiratory infection, managed care, Antibiotics, Managed care, Respiratory infection, amoxicillin, amoxicillin plus clavulanic acid, ampicillin, azithromycin, cephalosporin derivative, clarithromycin, cotrimoxazole, dicloxacillin, erythromycin, macrolide, penicillin G, sulfafurazole, tetracycline, antiinfective agent, adolescent, article, child, controlled study, drug use, health insurance, human, infection, major clinical study, otitis media, pneumonia, prescription, priority journal, clinical practice, drug utilization, female, infant, male, preschool child, statistics, Physician's Practice Patterns, Medical and Health Sciences, Psychology and Cognitive Sciences, Pediatrics, Biomedical and clinical sciences, Health sciences, Psychology
Abstract

BackgroundWidespread use of broad-spectrum antibiotics contributes to increasing rates of bacterial resistance to antibiotics. Second-generation macrolides have become popular for use among children because of their broad spectrum and favorable dosing and side-effect profiles, although experts do not generally recommend them for use as initial treatment of infections among younger children.ObjectiveTo assess trends in second-generation macrolide use from 1996 to 2000 among children treated as outpatients in 9 US health plans, including associated diagnoses and use as initial treatment.MethodsWe sampled claims data for 25000 children, 3 months to

Published
2004

8. Statistical Methods to Preserve Patient Privacy When Sharing and Analyzing Data

Author

Toh, Sengwee, primary, Mazor, Kathleen, additional, Yoshida, Kazuki, additional, Li, Xiaojuan, additional, Arterburn, David, additional, Raebel, Marsha, additional, Moyneur, Erick, additional, Gruber, Susan, additional, Curtis, Jeffrey, additional, Fisher, David, additional, Nowell, W. Benjamin, additional, Gallagher, Mia, additional, Richards, Allison, additional, Paolino, Andrea, additional, Fraser, James, additional, Amsden, Laura, additional, and Fireman, Bruce, additional

Published
2020
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10. Prevalence of chronic kidney disease among individuals with diabetes in the SUPREME-DM Project, 2005–2011

Author

Schroeder, Emily B., Powers, J. David, O’Connor, Patrick J., Nichols, Gregory A., Xu, Stanley, Desai, Jay R., Karter, Andrew J., Morales, Leo S., Newton, Katherine M., Pathak, Ram D., Vazquez-Benitez, Gabriela, Raebel, Marsha A., Butler, Melissa G., Lafata, Jennifer Elston, Reynolds, Kristi, Thomas, Abraham, Waitzfelder, Beth E., and Steiner, John F.

Published
2015
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28. Potential Drug-Drug Interactions in the Outpatient Setting

Author

Lafata, Jennifer Elston, Schultz, Lonni, Simpkins, Jan, Chan, K. Arnold, Horn, John R., Kaatz, Scott, Long, Charron, Platt, Richard, Raebel, Marsha A., Smith, David H., Xi, Huago, and Yood, Marianne Ulcickas

Published
2006

29. The prevalence and trends of antiviral medication use during pregnancy in the US: a population-based study of 664,297 deliveries in 2001-2007

Author

Avalos, Lyndsay A., Chen, Hong, Yang, Chunmei, Andrade, Susan E., Cooper, William O., Cheetham, Craig T., Davis, Robert L., Dublin, Sascha, Hammad, Tarek A., Kaplan, Sigal, Pawloski, Pamala A., Raebel, Marsha A., Scott, Pamela E., Smith, David H., Toh, Sengwee, and Li, De-Kun

Subjects
Medicine, Preventive -- Research, Drug abuse in pregnancy -- Research, Antiviral agents -- Dosage and administration -- Research, Preventive health services -- Research, Pregnancy, Complications of -- Prevention -- Patient outcomes, Health care industry
Abstract

To evaluate the prevalence, trends, timing and duration of exposure to antiviral medications during pregnancy within a US cohort of pregnant women and to evaluate the proportion of deliveries with a viral infection diagnosis among women given antiviral medication during pregnancy. Live-born deliveries between 2001 and 2007, to women aged 15-45 years, were included from the Medication Exposure in Pregnancy Risk Evaluation Program, a collaborative research program between the U.S. Food and Drug Administration and eleven health plans. They were evaluated for prevalence, timing, duration, and temporal trends of exposure to antiviral medications during pregnancy. We also calculated the proportion of deliveries with a viral infection diagnosis among those exposed to antiviral medications. Among 664,297 live births, the overall prevalence of antiviral exposure during pregnancy was 4 % (n = 25,155). Between 2001 and 2007, antiviral medication exposure during pregnancy doubled from 2.5 to 5 %. The most commonly used antiviral medication was acyclovir, with 3 % of the deliveries being exposed and most of the exposure occurring after the 1st trimester. Most deliveries exposed to antiviral medications were exposed for less than 30 days (2 % of all live births). Forty percent of the women delivering an infant exposed to antiviral medications had a herpes diagnosis. Our findings highlight the increased prevalence of women delivering an infant exposed to antiviral medications over time. These findings support the need for large, well-designed studies to assess the safety and effectiveness of these medications during pregnancy. Keywords Antiviral medication * Exposure during pregnancy * Prevalence, Introduction Antiviral medications are used to treat or prevent viral infections such as herpes simplex virus (HSV), influenza A and B, hepatitis B(HBV) and C(HCV), and antiretrovirals are used to [...]

Published
2014
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32. Trimethoprim–sulfonamide use during the first trimester of pregnancy and the risk of congenital anomalies†

Author

Hansen, Craig, Andrade, Susan E., Freiman, Heather, Dublin, Sascha, Haffenreffer, Katie, Cooper, William O., Cheetham, Craig T., Toh, Sengwee, Li, De-Kun, Raebel, Marsha A., Kuntz, Jennifer L., Perrin, Nancy, Rosales, Gabriela A., Carter, Shelley, Pawloski, Pamala A., Maloney, Elizabeth M., Graham, David J., Sahin, Leyla, Scott, Pamela E., Yap, John, and Davis, Robert

Published
2016
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34. Identification of Stevens–Johnson syndrome and toxic epidermal necrolysis in electronic health record databases†

Author

Davis, Robert L., Gallagher, Mia A., Asgari, Maryam M., Eide, Melody J., Margolis, David J., Macy, Eric, Burmester, James K., Selvam, Nandini, Boscarino, Joseph A., Cromwell, Lee F., Feigelson, Heather S., Kuntz, Jennifer L., Pawloski, Pamala A., Penfold, Robert B., Raebel, Marsha A., Sridhar, Gayathri, Wu, Ann, La Grenade, Lois A., Pacanowski, Michael A., and Pinheiro, Simone P.

Published
2015
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39. Prevalence and trends in the use of antipsychotic medications during pregnancy in the U.S., 2001–2007: a population-based study of 585,615 deliveries

Author

Toh, Sengwee, Li, Qian, Cheetham, T. Craig, Cooper, William O., Davis, Robert L., Dublin, Sascha, Hammad, Tarek A., Li, De-Kun, Pawloski, Pamala A., Pinheiro, Simone P., Raebel, Marsha A., Scott, Pamela E., Smith, David H., Bobo, William V., Lawrence, Jean M., Dashevsky, Inna, Haffenreffer, Katherine, Avalos, Lyndsay A., and Andrade, Susan E.

Published
2013
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40. Prevalence of prescription opioid use during pregnancy in eight US health plans during 2001–2014

Author

Pocobelli, Gaia, primary, Dublin, Sascha, additional, Bobb, Jennifer F., additional, Albertson‐Junkans, Ladia, additional, Andrade, Susan, additional, Cheetham, T. Craig, additional, Salgado, Gladys, additional, Griffin, Marie R., additional, Raebel, Marsha A., additional, Smith, David, additional, Li, De‐Kun, additional, Pawloski, Pamala A., additional, Toh, Sengwee, additional, Taylor, Lockwood, additional, Hua, Wei, additional, Horn, Pamela, additional, Trinidad, James P., additional, and Boudreau, Denise M., additional

Published
2021
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41. Medication Exposure in Pregnancy Risk Evaluation Program

Author

Andrade, Susan E., Davis, Robert L., Cheetham, T. Craig, Cooper, William O., Li, De-Kun, Amini, Thushi, Beaton, Sarah J., Dublin, Sascha, Hammad, Tarek A., Pawloski, Pamala A., Raebel, Marsha A., Smith, David H., Staffa, Judy A., Toh, Sengwee, Dashevsky, Inna, Haffenreffer, Katherine, Lane, Kimberly, Platt, Richard, and Scott, Pamela E.

Published
2012
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45. Intensification of antihyperglycemic therapy among patients with incident diabetes: a Surveillance Prevention and Management of Diabetes Mellitus (SUPREME-DM) study

Author

Raebel, Marsha A., Ellis, Jennifer L., Schroeder, Emily B., Xu, Stanley, OʼConnor, Patrick J., Segal, Jodi B., Butler, Melissa G., Schmittdiel, Julie A., Kirchner, Lester H., Goodrich, Glenn K., Lawrence, Jean M., Nichols, Gregory A., Newton, Katherine M., Pathak, Ram D., and Steiner, John F.

Published
2014
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