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335 results on '"Raffa, Giuseppe Maria"'

1. Author Correction: Regional antibiotic delivery for sternal wound infection prophylaxis a systematic review and meta-analysis of randomized controlled trials

Author

Kowalewski, Mariusz, Kołodziejczak, Michalina M., Urbanowicz, Tomasz, De Piero, Maria Elena, Mariani, Silvia, Pasierski, Michał, Makhoul, Maged, Comanici, Maria, Dąbrowski, Emil Julian, Matteucci, Matteo, Massimi, Giulio, Litwinowicz, Radosław, Kowalówka, Adam, Wańha, Wojciech, Jiritano, Federica, Martucci, Gennaro, Raffa, Giuseppe Maria, Malvindi, Pietro Giorgio, Kuźma, Łukasz, Suwalski, Piotr, Lorusso, Roberto, Meani, Paolo, and Lazar, Harold

Published
2024
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3. Regional antibiotic delivery for sternal wound infection prophylaxis a systematic review and meta-analysis of randomized controlled trials

Author

Kowalewski, Mariusz, Kołodziejczak, Michalina M., Urbanowicz, Tomasz, De Piero, Maria Elena, Mariani, Silvia, Pasierski, Michał, Makhoul, Maged, Comanici, Maria, Dąbrowski, Emil Julian, Matteucci, Matteo, Massimi, Giulio, Litwinowicz, Radosław, Kowalówka, Adam, Wańha, Wojciech, Jiritano, Federica, Martucci, Gennaro, Raffa, Giuseppe Maria, Malvindi, Pietro Giorgio, Kuźma, Łukasz, Suwalski, Piotr, Lorusso, Roberto, Meani, Paolo, and Lazar, Harold

Published
2024
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4. Neurologic complications in patients receiving aortic versus subclavian versus femoral arterial cannulation for post-cardiotomy extracorporeal life support: results of the PELS observational multicenter study

Author

Chiarini, Giovanni, Mariani, Silvia, Schaefer, Anne-Kristin, van Bussel, Bas C. T., Di Mauro, Michele, Wiedemann, Dominik, Saeed, Diyar, Pozzi, Matteo, Botta, Luca, Boeken, Udo, Samalavicius, Robertas, Bounader, Karl, Hou, Xiaotong, Bunge, Jeroen J. H., Buscher, Hergen, Salazar, Leonardo, Meyns, Bart, Herr, Daniel, Matteucci, Sacha, Sponga, Sandro, Ramanathan, Kollengode, Russo, Claudio, Formica, Francesco, Sakiyalak, Pranya, Fiore, Antonio, Camboni, Daniele, Raffa, Giuseppe Maria, Diaz, Rodrigo, Wang, I-wen, Jung, Jae-Seung, Belohlavek, Jan, Pellegrino, Vin, Bianchi, Giacomo, Pettinari, Matteo, Barbone, Alessandro, Garcia, José P., Shekar, Kiran, Whitman, Glenn J. R., and Lorusso, Roberto

Published
2024
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5. Features and outcomes of female and male patients requiring postcardiotomy extracorporeal life support

Author

Heuts, Samuel, Conci, Luca, Szalkiewicz, Philipp, Lehmann, Sven, Khalil, Jawad, Obadia, Jean-Francois, Kalampokas, Nikolaos, Jankuviene, Agne, Flecher, Erwan, Reis Miranda, Dinis Dos, Sriranjan, Kogulan, Herr, Daniel, Vedadi, Nazli, Di Eusanio, Marco, MacLaren, Graeme, Ramanathan, Kollengode, Costetti, Alessandro, Schmid, Chistof, Castillo, Roberto, Grus, Tomas, Mikulenka, Vladimir, Solinas, Marco, Mariani, Silvia, Ravaux, Justine Mafalda, van Bussel, Bas C.T., De Piero, Maria Elena, van Kruijk, Sander M.J., Schaefer, Anne-Kristin, Wiedemann, Dominik, Saeed, Diyar, Pozzi, Matteo, Loforte, Antonio, Boeken, Udo, Samalavicius, Robertas, Bounader, Karl, Hou, Xiaotong, Bunge, Jeroen J.H., Buscher, Hergen, Salazar, Leonardo, Meyns, Bart, Mazzeffi, Michael A., Matteucci, Sacha, Sponga, Sandro, Sorokin, Vitaly, Russo, Claudio, Formica, Francesco, Sakiyalak, Pranya, Fiore, Antonio, Camboni, Daniele, Raffa, Giuseppe Maria, Diaz, Rodrigo, Wang, I-wen, Jung, Jae-Seung, Belohlavek, Jan, Pellegrino, Vin, Bianchi, Giacomo, Pettinari, Matteo, Barbone, Alessandro, Garcia, José P., Shekar, Kiran, Whitman, Glenn J.R., and Lorusso, Roberto

Published
2024
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6. Characteristics and Outcomes of Prolonged Venoarterial Extracorporeal Membrane Oxygenation After Cardiac Surgery: The Post-Cardiotomy Extracorporeal Life Support (PELS-1) Cohort Study

Author

Bunge, Jeroen J. H., Mariani, Silvia, Meuwese, Christiaan, van Bussel, Bas C. T., Di Mauro, Michele, Wiedeman, Dominik, Saeed, Diyar, Pozzi, Matteo, Loforte, Antonio, Boeken, Udo, Samalavicius, Robertas, Bounader, Karl, Hou, Xiaotong, Buscher, Hergen, Salazar, Leonardo, Meyns, Bart, Herr, Daniel, Matteucci, Sacha, Sponga, Sandro, MacLaren, Graeme, Russo, Claudio, Formica, Francesco, Sakiyalak, Pranya, Fiore, Antonio, Camboni, Daniele, Raffa, Giuseppe Maria, Diaz, Rodrigo, Wang, I-wen, Jung, Jae-Seung, Belohlavek, Jan, Pellegrino, Vin, Bianchi, Giacomo, Pettinari, Matteo, Barbone, Alessandro, Garcia, José P., Shekar, Kiran, Whitman, Glenn J. R., Gommers, Diederik, Dos Reis Miranda, Dinis, Lorusso, Roberto, Heuts, Samuel, Ravaux, Justine, Schaefer, Anne-Kristin, Conci, Luca, Szalkiewicz, Philipp, Khalil, Jawad, Lehmann, Sven, Obadia, Jean-Francois, Kalampokas, Nikolaos, Jankuviene, Agne, Flecher, Erwan, Sriranjan, Kogulan, Mazzeffi, Michael A, Vedadi, Nazli, Di Eusanio, Marco, Sorokin, Vitaly, Ramanathan, Ram, Costetti, Alessandro, Schmid, Chistof, Castillo, Roberto, Mikulenka, Vladimir, Grus, Tomas, and Solinas, Marco

Published
2024
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7. Systematic review and meta-analysis of left atrial appendage closure's influence on early and long-term mortality and stroke

Author

Kowalewski, Mariusz, Święczkowski, Michał, Kuźma, Łukasz, Maesen, Bart, Dąbrowski, Emil Julian, Matteucci, Matteo, Batko, Jakub, Litwinowicz, Radosław, Kowalówka, Adam, Wańha, Wojciech, Jiritano, Federica, Raffa, Giuseppe Maria, Malvindi, Pietro Giorgio, Pannone, Luigi, Meani, Paolo, Lorusso, Roberto, Whitlock, Richard, La Meir, Mark, de Asmundis, Carlo, Cox, James, and Suwalski, Piotr

Published
2024
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8. Additional bypass graft or concomitant surgical ablation? Insights from the HEIST registry

Author

Suwalski, Piotr, Dąbrowski, Emil Julian, Batko, Jakub, Pasierski, Michał, Litwinowicz, Radosław, Kowalówka, Adam, Jasiński, Marek, Rogowski, Jan, Deja, Marek, Bartus, Krzysztof, Li, Tong, Matteucci, Matteo, Wańha, Wojciech, Meani, Paolo, Ronco, Daniele, Raffa, Giuseppe Maria, Malvindi, Pietro Giorgio, Kuźma, Łukasz, Lorusso, Roberto, Maesen, Bart, La Meir, Mark, Lazar, Harold, McCarthy, Patrick, Cox, James L., Rankin, Scott, and Kowalewski, Mariusz

Published
2024
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9. Evaluation of Left Ventricular Overload and Use of Unloading Techniques in Venoarterial Extracorporeal Life Support: A Nationwide Survey

Author

Meani, Paolo, Veronese, Giacomo, Todaro, Serena, Marchese, Giuseppe, Mondellini, Giulio M., Protti, Ilaria, de Arroyabe, Blanca Martinez-Lopez, Epis, Francesco, Pappalardo, Federico, Pedrazzini, Giovanna, Munch, Christopher, Margari, Vito, Grazioli, Lorenzo, Lorini, Ferdinando Luca, Cattaneo, Sergio, Montisci, Andrea, Ballotta, Andrea, Raffa, Giuseppe Maria, Carboni, Pietro, Lucchelli, Matteo, Avalli, Leonello, Babuin, Luciano, Belliato, Mirko, Bertini, Pietro, Guarracino, Fabio, Paternoster, Gianluca, Ajello, Valentina, Catena, Emanuele, Scolletta, Sabino, Franchi, Federico, Musazzi, Andrea, Pacini, Davide, Sangalli, Fabio, Attisani, Matteo, Rinaldi, Mauro, Grasselli, Giacomo, Mondino, Michele, Ranucci, Marco, and Lorusso, Roberto

Published
2024
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10. The importance of timing in postcardiotomy venoarterial extracorporeal membrane oxygenation: A descriptive multicenter observational study

Author

Ravaux, Justine, Schaefer, Ann-Kristin, Conci, Luca, Szalkiewicz, Philipp, Khalil, Jawad, Lehmann, Sven, Obadia, Jean-Francois, Kalampokas, Nikolaos, Flecher, Erwan, Miranda, Dinis Dos Reis, Sriranjan, Kogulan, Mazzeffi, Michael A., Vedadi, Nazli, Di Eusanio, Marco, MacLaren, Graeme, Sorokin, Vitaly, Costetti, Alessandro, Schmid, Chistof, Castillo, Roberto, Mikulenka, Vladimir, Solinas, Marco, Mariani, Silvia, Wang, I-wen, van Bussel, Bas C.T., Heuts, Samuel, Wiedemann, Dominik, Saeed, Diyar, van der Horst, Iwan C.C., Pozzi, Matteo, Loforte, Antonio, Boeken, Udo, Samalavicius, Robertas, Bounader, Karl, Hou, Xiaotong, Bunge, Jeroen J.H., Buscher, Hergen, Salazar, Leonardo, Meyns, Bart, Herr, Daniel, Matteucci, Sacha, Sponga, Sandro, Ramanathan, Kollengode, Russo, Claudio, Formica, Francesco, Sakiyalak, Pranya, Fiore, Antonio, Camboni, Daniele, Raffa, Giuseppe Maria, Diaz, Rodrigo, Jung, Jae-Seung, Belohlavek, Jan, Pellegrino, Vin, Bianchi, Giacomo, Pettinari, Matteo, Barbone, Alessandro, Garcia, José P., Shekar, Kiran, Whitman, Glenn, and Lorusso, Roberto

Published
2023
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11. Atrial fibrillation ablation improves late survival after concomitant cardiac surgery

Author

Kowalewski, Mariusz, Pasierski, Michał, Kołodziejczak, Michalina, Litwinowicz, Radosław, Kowalówka, Adam, Wańha, Wojciech, Łoś, Andrzej, Stefaniak, Sebastian, Wojakowski, Wojciech, Jemielity, Marek, Rogowski, Jan, Deja, Marek, Bartuś, Krzysztof, Mariani, Silvia, Li, Tong, Matteucci, Matteo, Ronco, Daniele, Massimi, Giulio, Jiritano, Federica, Meani, Paolo, Raffa, Giuseppe Maria, Malvindi, Pietro Giorgio, Zembala, Michał, Lorusso, Roberto, Cox, James L., and Suwalski, Piotr

Published
2023
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12. Topical vancomycin for sternal wound infection prophylaxis. A systematic review and updated meta-analysis of over 40,000 cardiac surgery patients

Author

Kowalewski, Mariusz, Pasierski, Michał, Makhoul, Maged, Comanici, Maria, Dąbrowski, Emil Julian, Matteucci, Matteo, Litwinowicz, Radosław, Kowalówka, Adam, Wańha, Wojciech, Jiritano, Federica, Fina, Dario, Martucci, Gennaro, Raffa, Giuseppe Maria, Malvindi, Pietro Giorgio, Kuźma, Łukasz, Suwalski, Piotr, Lorusso, Roberto, Meani, Paolo, and Lazar, Harold

Published
2023
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13. On-Support and Postweaning Mortality in Postcardiotomy Extracorporeal Membrane Oxygenation

Author

Khalil, Jawad, Lehmann, Sven, Obadia, Jean-Francois, Kalampokas, Nikolaos, Flecher, Erwan, Dos Reis Miranda, Dinis, Sriranjan, Kogulan, Mazzeffi, Michael A., Vedadi, Nazli, Di Eusanio, Marco, Sorokin, Vitaly, Ramanathan, Kollengode, Costetti, Alessandro, Schmid, Chistof, Castillo, Roberto, Mikulenka, Vladimir, Solinas, Marco, Mariani, Silvia, Schaefer, Anne-Kristin, van Bussel, Bas C.T., Di Mauro, Michele, Conci, Luca, Szalkiewicz, Philipp, De Piero, Maria Elena, Heuts, Samuel, Ravaux, Justine, van der Horst, Iwan C.C., Saeed, Diyar, Pozzi, Matteo, Loforte, Antonio, Boeken, Udo, Samalavicius, Robertas, Bounader, Karl, Hou, Xiaotong, Bunge, Jeroen J.H., Buscher, Hergen, Salazar, Leonardo, Meyns, Bart, Herr, Daniel, Matteucci, Sacha, Sponga, Sandro, MacLaren, Graeme, Russo, Claudio, Formica, Francesco, Sakiyalak, Pranya, Fiore, Antonio, Camboni, Daniele, Raffa, Giuseppe Maria, Diaz, Rodrigo, Wang, I-wen, Jung, Jae-Seung, Belohlavek, Jan, Pellegrino, Vin, Bianchi, Giacomo, Pettinari, Matteo, Barbone, Alessandro, Garcia, José P., Whitman, Glenn, Shekar, Kiran, Wiedemann, Dominik, and Lorusso, Roberto

Published
2023
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14. The Relation Between Obesity and Mortality in Postcardiotomy Venoarterial Membrane Oxygenation

Author

Ravaux, Justine, di Mauro, Michele, Schaefer, Ann-Kristin, Conci, Luca, Szalkiewicz, Philipp, Khalil, Jawad, Lehmann, Sven, Obadia, Jean-Francois, Kalampokas, Nikolaos, Flecher, Erwan, Reis Miranda, Dinis Dos, Buscher, Hergen, Herr, Daniel, Vedadi, Nazli, Di Eusanio, Marco, Maclaren, Graeme, Ramanathan, Ram, Costetti, Alessandro, Schmid, Chistof, Castillo, Roberto, Mikulenka, Vladimir, Solinas, Marco, Heuts, Samuel, Mariani, Silvia, van Bussel, Bas C.T., Boeken, Udo, Samalavicius, Robertas, Bounader, Karl, Hou, Xiaotong, Bunge, Jeroen J.H., Sriranjan, Kogulan, Wiedemann, Dominik, Saeed, Diyar, Pozzi, Matteo, Loforte, Antonio, Salazar, Leonardo, Meyns, Bart, Mazzeffi, Michael A., Matteucci, Sacha, Sponga, Sandro, Sorokin, Vitaly, Russo, Claudio, Formica, Francesco, Sakiyalak, Pranya, Fiore, Antonio, Camboni, Daniele, Raffa, Giuseppe Maria, Diaz, Rodrigo, Wang, I-wen, Jung, Jae-Seung, Belohlavek, Jan, Pellegrino, Vin, Bianchi, Giacomo, Pettinari, Matteo, Barbone, Alessandro, Garcia, José P., Shekar, Kiran, Whitman, Glenn, and Lorusso, Roberto

Published
2023
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15. Permanent pacemaker implantation after valve and arrhythmia surgery in patients with preoperative atrial fibrillation

Author

Kowalewski, Mariusz, Pasierski, Michał, Finke, Janina, Kołodziejczak, Michalina, Staromłyński, Jakub, Litwinowicz, Radosław, Filip, Grzegorz, Kowalówka, Adam, Wańha, Wojciech, Bławat, Przemysław, Łoś, Andrzej, Stefaniak, Sebastian, Wojakowski, Wojciech, Jemielity, Marek, Rogowski, Jan, Deja, Marek, Jagielak, Dariusz, Bartus, Krzysztof, Sierakowska, Katarzyna, Mariani, Silvia, Li, Tong, Ravaux, Justine Mafalda, Matteucci, Matteo, Ronco, Daniele, Jiritano, Federica, Fina, Dario, Martucci, Gennaro, Meani, Paolo, Raffa, Giuseppe Maria, Malvindi, Pietro Giorgio, Lorusso, Roberto, and Suwalski, Piotr

Published
2022
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16. COVID-19 and Extracorporeal Membrane Oxygenation

Author

on behalf of Thoracic Research Centre, Martucci, Gennaro, Słomka, Artur, Lebowitz, Steven Eric, Raffa, Giuseppe Maria, Malvindi, Pietro Giorgio, Coco, Valeria Lo, Swol, Justyna, Żekanowska, Ewa, Lorusso, Roberto, Wierzba, Waldemar, Suwalski, Piotr, Kowalewski, Mariusz, Crusio, Wim E., Series Editor, Dong, Haidong, Series Editor, Radeke, Heinfried H., Series Editor, Rezaei, Nima, Series Editor, Steinlein, Ortrud, Series Editor, Xiao, Junjie, Series Editor, Asea, Alexzander A. A., editor, and Kaur, Punit, editor

Published
2021
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17. Immunological and Hematological Response in COVID-19

Author

Słomka, Artur, Martucci, Gennaro, Raffa, Giuseppe Maria, Malvindi, Pietro Giorgio, Żekanowska, Ewa, Lorusso, Roberto, Suwalski, Piotr, Kowalewski, Mariusz, Crusio, Wim E., Series Editor, Dong, Haidong, Series Editor, Radeke, Heinfried H., Series Editor, Rezaei, Nima, Series Editor, Steinlein, Ortrud, Series Editor, Xiao, Junjie, Series Editor, Asea, Alexzander A. A., editor, and Kaur, Punit, editor

Published
2021
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20. Features and outcomes of female and male patients requiring postcardiotomy extracorporeal life support

Author

Mariani, Silvia, Ravaux, Justine Mafalda, van Bussel, Bas C.T., De Piero, Maria Elena, van Kruijk, Sander M.J., Schaefer, Anne Kristin, Wiedemann, Dominik, Saeed, Diyar, Pozzi, Matteo, Loforte, Antonio, Boeken, Udo, Samalavicius, Robertas, Bounader, Karl, Hou, Xiaotong, Bunge, Jeroen J.H., Buscher, Hergen, Salazar, Leonardo, Meyns, Bart, Mazzeffi, Michael A., Matteucci, Sacha, Sponga, Sandro, Sorokin, Vitaly, Russo, Claudio, Formica, Francesco, Sakiyalak, Pranya, Fiore, Antonio, Camboni, Daniele, Raffa, Giuseppe Maria, Diaz, Rodrigo, Wang, I. wen, Jung, Jae Seung, Belohlavek, Jan, Pellegrino, Vin, Bianchi, Giacomo, Pettinari, Matteo, Barbone, Alessandro, Garcia, José P., Shekar, Kiran, Whitman, Glenn J.R., Lorusso, Roberto, Heuts, Samuel, Conci, Luca, Szalkiewicz, Philipp, Lehmann, Sven, Khalil, Jawad, Obadia, Jean Francois, Kalampokas, Nikolaos, Jankuviene, Agne, Flecher, Erwan, Reis Miranda, Dinis Dos, Sriranjan, Kogulan, Herr, Daniel, Vedadi, Nazli, Di Eusanio, Marco, MacLaren, Graeme, Ramanathan, Kollengode, Costetti, Alessandro, Schmid, Chistof, Castillo, Roberto, Grus, Tomas, Mikulenka, Vladimir, Solinas, Marco, Mariani, Silvia, Ravaux, Justine Mafalda, van Bussel, Bas C.T., De Piero, Maria Elena, van Kruijk, Sander M.J., Schaefer, Anne Kristin, Wiedemann, Dominik, Saeed, Diyar, Pozzi, Matteo, Loforte, Antonio, Boeken, Udo, Samalavicius, Robertas, Bounader, Karl, Hou, Xiaotong, Bunge, Jeroen J.H., Buscher, Hergen, Salazar, Leonardo, Meyns, Bart, Mazzeffi, Michael A., Matteucci, Sacha, Sponga, Sandro, Sorokin, Vitaly, Russo, Claudio, Formica, Francesco, Sakiyalak, Pranya, Fiore, Antonio, Camboni, Daniele, Raffa, Giuseppe Maria, Diaz, Rodrigo, Wang, I. wen, Jung, Jae Seung, Belohlavek, Jan, Pellegrino, Vin, Bianchi, Giacomo, Pettinari, Matteo, Barbone, Alessandro, Garcia, José P., Shekar, Kiran, Whitman, Glenn J.R., Lorusso, Roberto, Heuts, Samuel, Conci, Luca, Szalkiewicz, Philipp, Lehmann, Sven, Khalil, Jawad, Obadia, Jean Francois, Kalampokas, Nikolaos, Jankuviene, Agne, Flecher, Erwan, Reis Miranda, Dinis Dos, Sriranjan, Kogulan, Herr, Daniel, Vedadi, Nazli, Di Eusanio, Marco, MacLaren, Graeme, Ramanathan, Kollengode, Costetti, Alessandro, Schmid, Chistof, Castillo, Roberto, Grus, Tomas, Mikulenka, Vladimir, and Solinas, Marco

Abstract

Objectives: Although cardiogenic shock requiring extracorporeal life support after cardiac surgery is associated with high mortality, the impact of sex on outcomes of postcardiotomy extracorporeal life support remains unclear with conflicting results in the literature. We compare patient characteristics, in-hospital outcomes, and overall survival between females and males requiring postcardiotomy extracorporeal life support. Methods: This retrospective, multicenter (34 centers), observational study included adults requiring postcardiotomy extracorporeal life support between 2000 and 2020. Preoperative, procedural, and extracorporeal life support characteristics, complications, and survival were compared between females and males. Association between sex and in-hospital survival was investigated through mixed Cox proportional hazard models. Results: This analysis included 1823 patients (female: 40.8%; median age: 66.0 years [interquartile range, 56.2-73.0 years]). Females underwent more mitral valve surgery (females: 38.4%, males: 33.1%, P = .019) and tricuspid valve surgery (feamales: 18%, males: 12.4%, P < .001), whereas males underwent more coronary artery surgery (females: 45.9%, males: 52.4%, P = .007). Extracorporeal life support implantation was more common intraoperatively in feamales (females: 64.1%, females: 59.1%) and postoperatively in males (females: 35.9%, males: 40.9%, P = .036). Ventricular unloading (females: 25.1%, males: 36.2%, P < .001) and intra-aortic balloon pumps (females: 25.8%, males: 36.8%, P < .001) were most frequently used in males. Females had more postoperative right ventricular failure (females: 24.1%, males: 19.1%, P = .016) and limb ischemia (females: 12.3%, males: 8.8%, P = .23). In-hospital mortality was 64.9% in females and 61.9% in males (P = .199) with no differences in 5-year survival (females: 20%, 95% CI, 17-23; males: 24%, 95% CI, 21-28; P = .069). Crude ha

Published
2024

21. Post-cardiotomy extracorporeal life support:A cohort of cannulation in the general ward

Author

Bari, Gabor, Mariani, Silvia, van Bussel, Bas C.T., Ravaux, Justine, Di Mauro, Michele, Schaefer, Anne, Khalil, Jawad, Pozzi, Matteo, Botta, Luca, Pacini, Davide, Boeken, Udo, Samalavicius, Robertas, Bounader, Karl, Hou, Xiaotong, Bunge, Jeroen J.H., Buscher, Hergen, Salazar, Leonardo, Meyns, Bart, Mazeffi, Michael, Matteucci, Sacha, Sponga, Sandro, MacLaren, Graeme, Russo, Claudio, Formica, Francesco, Sakiyalak, Pranya, Fiore, Antonio, Camboni, Daniele, Raffa, Giuseppe Maria, Diaz, Rodrigo, Wang, I. wen, Jung, Jae Seung, Belohlavek, Jan, Pellegrino, Vin, Bianchi, Giacomo, Pettinari, Matteo, Barbone, Alessandro, Garcia, José P., Shekar, Kiran, Whitman, Glenn, Lorusso, Roberto, Bari, Gabor, Mariani, Silvia, van Bussel, Bas C.T., Ravaux, Justine, Di Mauro, Michele, Schaefer, Anne, Khalil, Jawad, Pozzi, Matteo, Botta, Luca, Pacini, Davide, Boeken, Udo, Samalavicius, Robertas, Bounader, Karl, Hou, Xiaotong, Bunge, Jeroen J.H., Buscher, Hergen, Salazar, Leonardo, Meyns, Bart, Mazeffi, Michael, Matteucci, Sacha, Sponga, Sandro, MacLaren, Graeme, Russo, Claudio, Formica, Francesco, Sakiyalak, Pranya, Fiore, Antonio, Camboni, Daniele, Raffa, Giuseppe Maria, Diaz, Rodrigo, Wang, I. wen, Jung, Jae Seung, Belohlavek, Jan, Pellegrino, Vin, Bianchi, Giacomo, Pettinari, Matteo, Barbone, Alessandro, Garcia, José P., Shekar, Kiran, Whitman, Glenn, and Lorusso, Roberto

Abstract

Objectives: Post-cardiotomy extracorporeal life support (ECLS) cannulation might occur in a general post-operative ward due to emergent conditions. Its characteristics have been poorly reported and investigated This study investigates the characteristics and outcomes of adult patients receiving ECLS cannulation in a general post-operative cardiac ward. Methods: The Post-cardiotomy Extracorporeal Life Support (PELS) is a retrospective (2000–2020), multicenter (34 centers), observational study including adult patients who required ECLS for post-cardiotomy shock. This PELS sub-analysis analyzed patients´ characteristics, in-hospital outcomes, and long-term survival in patients cannulated for veno-arterial ECLS in the general ward, and further compared in-hospital survivors and non-survivors. Results: The PELS study included 2058 patients of whom 39 (1.9%) were cannulated in the general ward. Most patients underwent isolated coronary bypass grafting (CABG, n = 15, 38.5%) or isolated non-CABG operations (n = 20, 51.3%). The main indications to initiate ECLS included cardiac arrest (n = 17, 44.7%) and cardiogenic shock (n = 14, 35.9%). ECLS cannulation occurred after a median time of 4 (2–7) days post-operatively. Most patients' courses were complicated by acute kidney injury (n = 23, 59%), arrhythmias (n = 19, 48.7%), and postoperative bleeding (n = 20, 51.3%). In-hospital mortality was 84.6% (n = 33) with persistent heart failure (n = 11, 28.2%) as the most common cause of death. No peculiar differences were observed between in-hospital survivors and nonsurvivors. Conclusions: This study demonstrates that ECLS cannulation due to post-cardiotomy emergent adverse events in the general ward is rare, mainly occurring in preoperative low-risk patients and after a postoperative cardiac arrest. High complication rates and low in-hospital survival require further investigations to identify patients

Published
2024

22. Characteristics and Outcomes of Prolonged Venoarterial Extracorporeal Membrane Oxygenation after Cardiac Surgery:The Post-Cardiotomy Extracorporeal Life Support (PELS-1) Cohort Study

Author

Bunge, Jeroen J.H., Mariani, Silvia, Meuwese, Christiaan, Van Bussel, Bas C.T., Di Mauro, Michele, Wiedeman, Dominik, Saeed, Diyar, Pozzi, Matteo, Loforte, Antonio, Boeken, Udo, Samalavicius, Robertas, Bounader, Karl, Hou, Xiaotong, Buscher, Hergen, Salazar, Leonardo, Meyns, Bart, Herr, Daniel, Matteucci, Sacha, Sponga, Sandro, Maclaren, Graeme, Russo, Claudio, Formica, Francesco, Sakiyalak, Pranya, Fiore, Antonio, Camboni, Daniele, Raffa, Giuseppe Maria, Diaz, Rodrigo, Wang, I. Wen, Jung, Jae Seung, Belohlavek, Jan, Pellegrino, Vin, Bianchi, Giacomo, Pettinari, Matteo, Barbone, Alessandro, Garcia, José P., Shekar, Kiran, Whitman, Glenn J.R., Gommers, Diederik, Dos Reis Miranda, Dinis, Lorusso, Roberto, Heuts, Samuel, Ravaux, Justine, Schaefer, Anne Kristin, Conci, Luca, Szalkiewicz, Philipp, Khalil, Jawad, Lehmann, Sven, Obadia, Jean Francois, Kalampokas, Nikolaos, Jankuviene, Agne, Flecher, Erwan, Sriranjan, Kogulan, Mazzeffi, Michael A., Vedadi, Nazli, Di Eusanio, Marco, Sorokin, Vitaly, Ramanathan, Ram, Costetti, Alessandro, Schmid, Chistof, Castillo, Roberto, Mikulenka, Vladimir, Grus, Tomas, Solinas, Marco, Bunge, Jeroen J.H., Mariani, Silvia, Meuwese, Christiaan, Van Bussel, Bas C.T., Di Mauro, Michele, Wiedeman, Dominik, Saeed, Diyar, Pozzi, Matteo, Loforte, Antonio, Boeken, Udo, Samalavicius, Robertas, Bounader, Karl, Hou, Xiaotong, Buscher, Hergen, Salazar, Leonardo, Meyns, Bart, Herr, Daniel, Matteucci, Sacha, Sponga, Sandro, Maclaren, Graeme, Russo, Claudio, Formica, Francesco, Sakiyalak, Pranya, Fiore, Antonio, Camboni, Daniele, Raffa, Giuseppe Maria, Diaz, Rodrigo, Wang, I. Wen, Jung, Jae Seung, Belohlavek, Jan, Pellegrino, Vin, Bianchi, Giacomo, Pettinari, Matteo, Barbone, Alessandro, Garcia, José P., Shekar, Kiran, Whitman, Glenn J.R., Gommers, Diederik, Dos Reis Miranda, Dinis, Lorusso, Roberto, Heuts, Samuel, Ravaux, Justine, Schaefer, Anne Kristin, Conci, Luca, Szalkiewicz, Philipp, Khalil, Jawad, Lehmann, Sven, Obadia, Jean Francois, Kalampokas, Nikolaos, Jankuviene, Agne, Flecher, Erwan, Sriranjan, Kogulan, Mazzeffi, Michael A., Vedadi, Nazli, Di Eusanio, Marco, Sorokin, Vitaly, Ramanathan, Ram, Costetti, Alessandro, Schmid, Chistof, Castillo, Roberto, Mikulenka, Vladimir, Grus, Tomas, and Solinas, Marco

Abstract

OBJECTIVES: Most post-cardiotomy (PC) extracorporeal membrane oxygenation (ECMO) runs last less than 7 days. Studies on the outcomes of longer runs have provided conflicting results. This study investigates patient characteristics and short- and long-term outcomes in relation to PC ECMO duration, with a focus on prolonged (> 7 d) ECMO. DESIGN: Retrospective observational cohort study. SETTING: Thirty-four centers from 16 countries between January 2000 and December 2020. PATIENTS: Adults requiring post PC ECMO between 2000 and 2020. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Characteristics, in-hospital, and post-discharge outcomes were compared among patients categorized by ECMO duration. Survivors and nonsurvivors were compared in the subgroup of patients with ECMO duration greater than 7 days. The primary outcome was in-hospital mortality. Two thousand twenty-one patients were included who required PC ECMO for 0-3 days (n = 649 [32.1%]), 4-7 days (n = 776 [38.3%]), 8-10 days (n = 263 [13.0%]), and greater than 10 days (n = 333 [16.5%]). There were no major differences in the investigated preoperative and procedural characteristics among ECMO duration groups. However, the longer ECMO duration category was associated with multiple complications including bleeding, acute kidney injury, arrhythmias, and sepsis. Hospital mortality followed a U-shape curve, with lowest mortality in patients with ECMO duration of 4-7 days (n = 394, 50.8%) and highest in patients with greater than 10 days ECMO support (n = 242, 72.7%). There was no significant difference in post-discharge survival between ECMO duration groups. In patients with ECMO duration greater than 7 days, age, comorbidities, valvular diseases, and complex procedures were associated with nonsurvival. CONCLUSIONS: Nearly 30% of PC ECMO patients were supported for greater than 7 days. In-hospital mortality increased after 7 days of support, especially in patients undergoing valvular and complex surgery

Published
2024

23. Neurologic complications in patients receiving aortic versus subclavian versus femoral arterial cannulation for post-cardiotomy extracorporeal life support:results of the PELS observational multicenter study

Author

Chiarini, Giovanni, Mariani, Silvia, Schaefer, Anne Kristin, van Bussel, Bas C.T., Di Mauro, Michele, Wiedemann, Dominik, Saeed, Diyar, Pozzi, Matteo, Botta, Luca, Boeken, Udo, Samalavicius, Robertas, Bounader, Karl, Hou, Xiaotong, Bunge, Jeroen J.H., Buscher, Hergen, Salazar, Leonardo, Meyns, Bart, Herr, Daniel, Matteucci, Sacha, Sponga, Sandro, Ramanathan, Kollengode, Russo, Claudio, Formica, Francesco, Sakiyalak, Pranya, Fiore, Antonio, Camboni, Daniele, Raffa, Giuseppe Maria, Diaz, Rodrigo, Wang, I. Wen, Jung, Jae Seung, Belohlavek, Jan, Pellegrino, Vin, Bianchi, Giacomo, Pettinari, Matteo, Barbone, Alessandro, Garcia, José P., Shekar, Kiran, Whitman, Glenn J.R., Lorusso, Roberto, Chiarini, Giovanni, Mariani, Silvia, Schaefer, Anne Kristin, van Bussel, Bas C.T., Di Mauro, Michele, Wiedemann, Dominik, Saeed, Diyar, Pozzi, Matteo, Botta, Luca, Boeken, Udo, Samalavicius, Robertas, Bounader, Karl, Hou, Xiaotong, Bunge, Jeroen J.H., Buscher, Hergen, Salazar, Leonardo, Meyns, Bart, Herr, Daniel, Matteucci, Sacha, Sponga, Sandro, Ramanathan, Kollengode, Russo, Claudio, Formica, Francesco, Sakiyalak, Pranya, Fiore, Antonio, Camboni, Daniele, Raffa, Giuseppe Maria, Diaz, Rodrigo, Wang, I. Wen, Jung, Jae Seung, Belohlavek, Jan, Pellegrino, Vin, Bianchi, Giacomo, Pettinari, Matteo, Barbone, Alessandro, Garcia, José P., Shekar, Kiran, Whitman, Glenn J.R., and Lorusso, Roberto

Abstract

BACKGROUND: Cerebral perfusion may change depending on arterial cannulation site and may affect the incidence of neurologic adverse events in post-cardiotomy extracorporeal life support (ECLS). The current study compares patients' neurologic outcomes with three commonly used arterial cannulation strategies (aortic vs. subclavian/axillary vs. femoral artery) to evaluate if each ECLS configuration is associated with different rates of neurologic complications. METHODS: This retrospective, multicenter (34 centers), observational study included adults requiring post-cardiotomy ECLS between January 2000 and December 2020 present in the Post-Cardiotomy Extracorporeal Life Support (PELS) Study database. Patients with Aortic, Subclavian/Axillary and Femoral cannulation were compared on the incidence of a composite neurological end-point (ischemic stroke, cerebral hemorrhage, brain edema). Secondary outcomes were overall in-hospital mortality, neurologic complications as cause of in-hospital death, and post-operative minor neurologic complications (seizures). Association between cannulation and neurological outcomes were investigated through linear mixed-effects models. RESULTS: This study included 1897 patients comprising 26.5% Aortic (n = 503), 20.9% Subclavian/Axillary (n = 397) and 52.6% Femoral (n = 997) cannulations. The Subclavian/Axillary group featured a more frequent history of hypertension, smoking, diabetes, previous myocardial infarction, dialysis, peripheral artery disease and previous stroke. Neuro-monitoring was used infrequently in all groups. Major neurologic complications were more frequent in Subclavian/Axillary (Aortic: n = 79, 15.8%; Subclavian/Axillary: n = 78, 19.6%; Femoral: n = 118, 11.9%; p < 0.001) also after mixed-effects model adjustment (OR 1.53 [95% CI 1.02-2.31], p = 0.041). Seizures were more common in Subclavian/Axillary (n = 13, 3.4%) than Aortic (n = 9, 1.8%) and Femoral cannul

Published
2024

25. Immunological and Hematological Response in COVID-19

Author

Słomka, Artur, primary, Martucci, Gennaro, additional, Raffa, Giuseppe Maria, additional, Malvindi, Pietro Giorgio, additional, Żekanowska, Ewa, additional, Lorusso, Roberto, additional, Suwalski, Piotr, additional, and Kowalewski, Mariusz, additional

Published
2021
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26. The importance of timing in postcardiotomy venoarterial extracorporeal membrane oxygenation: A descriptive multicenter observational study

Author

Mariani, Silvia, primary, Wang, I-wen, additional, van Bussel, Bas C.T., additional, Heuts, Samuel, additional, Wiedemann, Dominik, additional, Saeed, Diyar, additional, van der Horst, Iwan C.C., additional, Pozzi, Matteo, additional, Loforte, Antonio, additional, Boeken, Udo, additional, Samalavicius, Robertas, additional, Bounader, Karl, additional, Hou, Xiaotong, additional, Bunge, Jeroen J.H., additional, Buscher, Hergen, additional, Salazar, Leonardo, additional, Meyns, Bart, additional, Herr, Daniel, additional, Matteucci, Sacha, additional, Sponga, Sandro, additional, Ramanathan, Kollengode, additional, Russo, Claudio, additional, Formica, Francesco, additional, Sakiyalak, Pranya, additional, Fiore, Antonio, additional, Camboni, Daniele, additional, Raffa, Giuseppe Maria, additional, Diaz, Rodrigo, additional, Jung, Jae-Seung, additional, Belohlavek, Jan, additional, Pellegrino, Vin, additional, Bianchi, Giacomo, additional, Pettinari, Matteo, additional, Barbone, Alessandro, additional, Garcia, José P., additional, Shekar, Kiran, additional, Whitman, Glenn, additional, Lorusso, Roberto, additional, Ravaux, Justine, additional, Schaefer, Ann-Kristin, additional, Conci, Luca, additional, Szalkiewicz, Philipp, additional, Khalil, Jawad, additional, Lehmann, Sven, additional, Obadia, Jean-Francois, additional, Kalampokas, Nikolaos, additional, Flecher, Erwan, additional, Miranda, Dinis Dos Reis, additional, Sriranjan, Kogulan, additional, Mazzeffi, Michael A., additional, Vedadi, Nazli, additional, Di Eusanio, Marco, additional, MacLaren, Graeme, additional, Sorokin, Vitaly, additional, Costetti, Alessandro, additional, Schmid, Chistof, additional, Castillo, Roberto, additional, Mikulenka, Vladimir, additional, and Solinas, Marco, additional

Published
2023
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28. On-Support and Postweaning Mortality in Postcardiotomy Extracorporeal Membrane Oxygenation

Author

Mariani, Silvia, primary, Schaefer, Anne-Kristin, additional, van Bussel, Bas C.T., additional, Di Mauro, Michele, additional, Conci, Luca, additional, Szalkiewicz, Philipp, additional, De Piero, Maria Elena, additional, Heuts, Samuel, additional, Ravaux, Justine, additional, van der Horst, Iwan C.C., additional, Saeed, Diyar, additional, Pozzi, Matteo, additional, Loforte, Antonio, additional, Boeken, Udo, additional, Samalavicius, Robertas, additional, Bounader, Karl, additional, Hou, Xiaotong, additional, Bunge, Jeroen J.H., additional, Buscher, Hergen, additional, Salazar, Leonardo, additional, Meyns, Bart, additional, Herr, Daniel, additional, Matteucci, Sacha, additional, Sponga, Sandro, additional, MacLaren, Graeme, additional, Russo, Claudio, additional, Formica, Francesco, additional, Sakiyalak, Pranya, additional, Fiore, Antonio, additional, Camboni, Daniele, additional, Raffa, Giuseppe Maria, additional, Diaz, Rodrigo, additional, Wang, I-wen, additional, Jung, Jae-Seung, additional, Belohlavek, Jan, additional, Pellegrino, Vin, additional, Bianchi, Giacomo, additional, Pettinari, Matteo, additional, Barbone, Alessandro, additional, Garcia, José P., additional, Whitman, Glenn, additional, Shekar, Kiran, additional, Wiedemann, Dominik, additional, Lorusso, Roberto, additional, Khalil, Jawad, additional, Lehmann, Sven, additional, Obadia, Jean-Francois, additional, Kalampokas, Nikolaos, additional, Flecher, Erwan, additional, Dos Reis Miranda, Dinis, additional, Sriranjan, Kogulan, additional, Mazzeffi, Michael A., additional, Vedadi, Nazli, additional, Di Eusanio, Marco, additional, Sorokin, Vitaly, additional, Ramanathan, Kollengode, additional, Costetti, Alessandro, additional, Schmid, Chistof, additional, Castillo, Roberto, additional, Mikulenka, Vladimir, additional, and Solinas, Marco, additional

Published
2023
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32. Patient and Management Variables Associated With Survival After Postcardiotomy Extracorporeal Membrane Oxygenation in Adults: The PELS‐1 Multicenter Cohort Study

Author

Mariani, Silvia, primary, Heuts, Samuel, additional, van Bussel, Bas C. T., additional, Di Mauro, Michele, additional, Wiedemann, Dominik, additional, Saeed, Diyar, additional, Pozzi, Matteo, additional, Loforte, Antonio, additional, Boeken, Udo, additional, Samalavicius, Robertas, additional, Bounader, Karl, additional, Hou, Xiaotong, additional, Bunge, Jeroen J. H., additional, Buscher, Hergen, additional, Salazar, Leonardo, additional, Meyns, Bart, additional, Herr, Daniel, additional, Matteucci, Marco L. Sacha, additional, Sponga, Sandro, additional, MacLaren, Graeme, additional, Russo, Claudio, additional, Formica, Francesco, additional, Sakiyalak, Pranya, additional, Fiore, Antonio, additional, Camboni, Daniele, additional, Raffa, Giuseppe Maria, additional, Diaz, Rodrigo, additional, Wang, I‐wen, additional, Jung, Jae‐Seung, additional, Belohlavek, Jan, additional, Pellegrino, Vin, additional, Bianchi, Giacomo, additional, Pettinari, Matteo, additional, Barbone, Alessandro, additional, Garcia, José P., additional, Shekar, Kiran, additional, Whitman, Glenn J. R., additional, Lorusso, Roberto, additional, Ravaux, Justine, additional, Schaefer, Anne‐Kristin, additional, Conci, Luca, additional, Szalkiewicz, Philipp, additional, Khalil, Jawad, additional, Lehmann, Sven, additional, Obadia, Jean‐Francois, additional, Kalampokas, Nikolaos, additional, Flecher, Erwan, additional, Miranda, Dinis Dos Reis, additional, Sriranjan, Kogulan, additional, Mazzeffi, Michael A., additional, Vedadi, Nazli, additional, Di Eusanio, Marco, additional, Sorokin, Vitaly, additional, Ramanathan, Kollengode, additional, Costetti, Alessandro, additional, Schmid, Chistof, additional, Castillo, Roberto, additional, Mikulenka, Vladimir, additional, and Solinas, Marco, additional

Published
2023
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33. The Relation Between Obesity and Mortality in Postcardiotomy Venoarterial Membrane Oxygenation

Author

Heuts, Samuel, primary, Mariani, Silvia, additional, van Bussel, Bas C.T., additional, Boeken, Udo, additional, Samalavicius, Robertas, additional, Bounader, Karl, additional, Hou, Xiaotong, additional, Bunge, Jeroen J.H., additional, Sriranjan, Kogulan, additional, Wiedemann, Dominik, additional, Saeed, Diyar, additional, Pozzi, Matteo, additional, Loforte, Antonio, additional, Salazar, Leonardo, additional, Meyns, Bart, additional, Mazzeffi, Michael A., additional, Matteucci, Sacha, additional, Sponga, Sandro, additional, Sorokin, Vitaly, additional, Russo, Claudio, additional, Formica, Francesco, additional, Sakiyalak, Pranya, additional, Fiore, Antonio, additional, Camboni, Daniele, additional, Raffa, Giuseppe Maria, additional, Diaz, Rodrigo, additional, Wang, I-wen, additional, Jung, Jae-Seung, additional, Belohlavek, Jan, additional, Pellegrino, Vin, additional, Bianchi, Giacomo, additional, Pettinari, Matteo, additional, Barbone, Alessandro, additional, Garcia, José P., additional, Shekar, Kiran, additional, Whitman, Glenn, additional, Lorusso, Roberto, additional, Ravaux, Justine, additional, di Mauro, Michele, additional, Schaefer, Ann-Kristin, additional, Conci, Luca, additional, Szalkiewicz, Philipp, additional, Khalil, Jawad, additional, Lehmann, Sven, additional, Obadia, Jean-Francois, additional, Kalampokas, Nikolaos, additional, Flecher, Erwan, additional, Reis Miranda, Dinis Dos, additional, Buscher, Hergen, additional, Herr, Daniel, additional, Vedadi, Nazli, additional, Di Eusanio, Marco, additional, Maclaren, Graeme, additional, Ramanathan, Ram, additional, Costetti, Alessandro, additional, Schmid, Chistof, additional, Castillo, Roberto, additional, Mikulenka, Vladimir, additional, and Solinas, Marco, additional

Published
2023
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34. Meta-analysis of uninterrupted as compared to interrupted oral anticoagulation with or without bridging in patients undergoing coronary angiography with or without percutaneous coronary intervention

Author

Kowalewski, Mariusz, Suwalski, Piotr, Raffa, Giuseppe Maria, Słomka, Artur, Kowalkowska, Magdalena Ewa, Szwed, Krzysztof Aleksander, Borkowska, Alina, Kowalewski, Janusz, Malvindi, Pietro Giorgio, Undas, Anetta, Windyga, Jerzy, Pawliszak, Wojciech, Anisimowicz, Lech, Carrel, Thierry, Paparella, Domenico, and Lip, Gregory Y.H.

Published
2016
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37. Off-pump coronary artery bypass grafting improves short-term outcomes in high-risk patients compared with on-pump coronary artery bypass grafting: Meta-analysis

Author

Kowalewski, Mariusz, Pawliszak, Wojciech, Malvindi, Pietro Giorgio, Bokszanski, Marek Pawel, Perlinski, Damian, Raffa, Giuseppe Maria, Kowalkowska, Magdalena Ewa, Zaborowska, Katarzyna, Navarese, Eliano Pio, Kolodziejczak, Michalina, Kowalewski, Janusz, Tarelli, Giuseppe, Taggart, David Paul, and Anisimowicz, Lech

Published
2016
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38. The impact of Centre’s heart transplant status and volume on in-hospital outcomes following extracorporeal membrane oxygenation for refractory post-cardiotomy cardiogenic shock: a meta-analysis

Author

Kowalewski, Mariusz, Raffa, Giuseppe Maria, Zieliński, Kamil, Alanazi, Musab, Gilbers, Martijn, Heuts, Sam, Natour, Ehsan, Bidar, Elham, Schreurs, Rick, Delnoij, Thijs, Driessen, Rob, Sels, Jan-Willem, van de Poll, Marcel, Roekaerts, Paul, Meani, Paolo, Maessen, Jos, Suwalski, Piotr, and Lorusso, Roberto

Published
2020
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41. Patient and Management Variables Associated With Survival After Postcardiotomy Extracorporeal Membrane Oxygenation in Adults:The PELS-1 Multicenter Cohort Study

Author

Mariani, Silvia, Heuts, Samuel, van Bussel, Bas C.T., Di Mauro, Michele, Wiedemann, Dominik, Saeed, Diyar, Pozzi, Matteo, Loforte, Antonio, Boeken, Udo, Samalavicius, Robertas, Bounader, Karl, Hou, Xiaotong, Bunge, Jeroen J.H., Buscher, Hergen, Salazar, Leonardo, Meyns, Bart, Herr, Daniel, Matteucci, Marco L.Sacha, Sponga, Sandro, MacLaren, Graeme, Russo, Claudio, Formica, Francesco, Sakiyalak, Pranya, Fiore, Antonio, Camboni, Daniele, Raffa, Giuseppe Maria, Diaz, Rodrigo, Wang, I. Wen, Jung, Jae Seung, Belohlavek, Jan, Pellegrino, Vin, Bianchi, Giacomo, Pettinari, Matteo, Barbone, Alessandro, Garcia, José P., Shekar, Kiran, Whitman, Glenn J.R., Lorusso, Roberto, Mariani, Silvia, Heuts, Samuel, van Bussel, Bas C.T., Di Mauro, Michele, Wiedemann, Dominik, Saeed, Diyar, Pozzi, Matteo, Loforte, Antonio, Boeken, Udo, Samalavicius, Robertas, Bounader, Karl, Hou, Xiaotong, Bunge, Jeroen J.H., Buscher, Hergen, Salazar, Leonardo, Meyns, Bart, Herr, Daniel, Matteucci, Marco L.Sacha, Sponga, Sandro, MacLaren, Graeme, Russo, Claudio, Formica, Francesco, Sakiyalak, Pranya, Fiore, Antonio, Camboni, Daniele, Raffa, Giuseppe Maria, Diaz, Rodrigo, Wang, I. Wen, Jung, Jae Seung, Belohlavek, Jan, Pellegrino, Vin, Bianchi, Giacomo, Pettinari, Matteo, Barbone, Alessandro, Garcia, José P., Shekar, Kiran, Whitman, Glenn J.R., and Lorusso, Roberto

Abstract

Background Extracorporeal membrane oxygenation (ECMO) has been increasingly used for postcardiotomy cardiogenic shock, but without a concomitant reduction in observed in-hospital mortality. Long-term outcomes are unknown. This study describes patients' characteristics, in-hospital outcome, and 10-year survival after postcardiotomy ECMO. Variables associated with in-hospital and postdischarge mortality are investigated and reported. Methods and Results The retrospective international multicenter observational PELS-1 (Postcardiotomy Extracorporeal Life Support) study includes data on adults requiring ECMO for postcardiotomy cardiogenic shock between 2000 and 2020 from 34 centers. Variables associated with mortality were estimated preoperatively, intraoperatively, during ECMO, and after the occurrence of any complications, and then analyzed at different time points during a patient's clinical course, through mixed Cox proportional hazards models containing fixed and random effects. Follow-up was established by institutional chart review or contacting patients. This analysis included 2058 patients (59% were men; median [interquartile range] age, 65.0 [55.0-72.0] years). In-hospital mortality was 60.5%. Independent variables associated with in-hospital mortality were age (hazard ratio [HR], 1.02 [95% CI, 1.01-1.02]) and preoperative cardiac arrest (HR, 1.41 [95% CI, 1.15-1.73]). In the subgroup of hospital survivors, the overall 1-, 2-, 5-, and 10-year survival rates were 89.5% (95% CI, 87.0%-92.0%), 85.4% (95% CI, 82.5%-88.3%), 76.4% (95% CI, 72.5%-80.5%), and 65.9% (95% CI, 60.3%-72.0%), respectively. Variables associated with postdischarge mortality included older age, atrial fibrillation, emergency surgery, type of surgery, postoperative acute kidney injury, and postoperative septic shock. Conclusions In adults, in-hospital mortality after postcardiotomy ECMO remains high; however, two-thirds of those who are discharged from hospital survive up to 10 years. Patien

Published
2023

42. Heterogeneity in clinical practices for post-cardiotomy extracorporeal life support:A pilot survey from the PELS-1 multicenter study

Author

Mariani, Silvia, Bari, Gabor, Ravaux, Justine M., van Bussel, Bas C.T., De Piero, Maria Elena, Schaefer, Ann Kristin, Jawad, Khalil, Pozzi, Matteo, Loforte, Antonio, Kalampokas, Nikolaos, Jankuviene, Agne, Flecher, Erwan, Hou, Xiaotong, Bunge, Jeroen J.H., Sriranjan, Kogulan, Salazar, Leonardo, Meyns, Bart, Mazzeffi, Michael A., Matteucci, Sacha, Sponga, Sandro, Ramanathan, Kollengode, Costetti, Alessandro, Formica, Francesco, Sakiyalak, Pranya, Fiore, Antonio, Schmid, Chistof, Raffa, Giuseppe Maria, Castillo, Roberto, Wang, I. wen, Jung, Jae Seung, Grus, Tomas, Pellegrino, Vin, Bianchi, Giacomo, Pettinari, Matteo, Barbone, Alessandro, Garcia, José P., Kowalewski, Mariusz, Shekar, Kiran, Whitman, Glenn, Lorusso, Roberto, Mariani, Silvia, Bari, Gabor, Ravaux, Justine M., van Bussel, Bas C.T., De Piero, Maria Elena, Schaefer, Ann Kristin, Jawad, Khalil, Pozzi, Matteo, Loforte, Antonio, Kalampokas, Nikolaos, Jankuviene, Agne, Flecher, Erwan, Hou, Xiaotong, Bunge, Jeroen J.H., Sriranjan, Kogulan, Salazar, Leonardo, Meyns, Bart, Mazzeffi, Michael A., Matteucci, Sacha, Sponga, Sandro, Ramanathan, Kollengode, Costetti, Alessandro, Formica, Francesco, Sakiyalak, Pranya, Fiore, Antonio, Schmid, Chistof, Raffa, Giuseppe Maria, Castillo, Roberto, Wang, I. wen, Jung, Jae Seung, Grus, Tomas, Pellegrino, Vin, Bianchi, Giacomo, Pettinari, Matteo, Barbone, Alessandro, Garcia, José P., Kowalewski, Mariusz, Shekar, Kiran, Whitman, Glenn, and Lorusso, Roberto

Abstract

Background:High-quality evidence for post-cardiotomy extracorporeal life support (PC-ECLS) management is lacking. This study investigated real-world PC-ECLS clinical practices. Methods: This cross-sectional, multi-institutional, international pilot survey explored center organization, anticoagulation management, left ventricular unloading, distal limb perfusion, PC-ECLS monitoring, and transfusion practices. Twenty-nine questions were distributed among 34 hospitals participating in the Post-cardiotomy Extra-Corporeal Life Support Study. Results: Of the 32 centers [16 low-volume (50%); 16 high-volume (50%)] that responded, 16 (50%) had dedicated ECLS specialists. Twenty-six centers (81.3%) reported using additional mechanical circulatory supports. Anticoagulation practices were highly heterogeneous: 24 hospitals (75%) reported using patients bleeding status as a guide, without a specific threshold in 54.2% of cases. Transfusion targets ranged from 7 to 10 g/dL. Most centers used cardiac venting on a case-by-case basis (78.1%) and regular distal limb perfusion (84.4%). Nineteen (54.9%) centers reported dedicated monitoring protocols, including daily echocardiography (87.5%), Swan-Ganz catheterization (40.6%), cerebral near-infrared spectroscopy (53.1%), and multimodal assessment of limb ischemia. Inspection of the circuit (71.9%), oxygenator pressure drop (68.8%), plasma free hemoglobin (75%), d-dimer (59.4%), lactate dehydrogenase (56.3%), and fibrinogen (46.9%) are used to diagnose hemolysis and thrombosis. Conclusions: This study shows remarkable heterogeneity in clinical practices for PC-ECLS management. More standardized protocols and better implementation of the available evidence are recommended.

Published
2023

43. The importance of timing in postcardiotomy venoarterial extracorporeal membrane oxygenation:A descriptive multicenter observational study

Author

Mariani, Silvia, Wang, I. wen, van Bussel, Bas C.T., Heuts, Samuel, Wiedemann, Dominik, Saeed, Diyar, van der Horst, Iwan C.C., Pozzi, Matteo, Loforte, Antonio, Boeken, Udo, Samalavicius, Robertas, Bounader, Karl, Hou, Xiaotong, Bunge, Jeroen J.H., Buscher, Hergen, Salazar, Leonardo, Meyns, Bart, Herr, Daniel, Matteucci, Sacha, Sponga, Sandro, Ramanathan, Kollengode, Russo, Claudio, Formica, Francesco, Sakiyalak, Pranya, Fiore, Antonio, Camboni, Daniele, Raffa, Giuseppe Maria, Diaz, Rodrigo, Jung, Jae Seung, Belohlavek, Jan, Pellegrino, Vin, Bianchi, Giacomo, Pettinari, Matteo, Barbone, Alessandro, Garcia, José P., Shekar, Kiran, Whitman, Glenn, Lorusso, Roberto, Miranda, Dinis Dos Reis, Mariani, Silvia, Wang, I. wen, van Bussel, Bas C.T., Heuts, Samuel, Wiedemann, Dominik, Saeed, Diyar, van der Horst, Iwan C.C., Pozzi, Matteo, Loforte, Antonio, Boeken, Udo, Samalavicius, Robertas, Bounader, Karl, Hou, Xiaotong, Bunge, Jeroen J.H., Buscher, Hergen, Salazar, Leonardo, Meyns, Bart, Herr, Daniel, Matteucci, Sacha, Sponga, Sandro, Ramanathan, Kollengode, Russo, Claudio, Formica, Francesco, Sakiyalak, Pranya, Fiore, Antonio, Camboni, Daniele, Raffa, Giuseppe Maria, Diaz, Rodrigo, Jung, Jae Seung, Belohlavek, Jan, Pellegrino, Vin, Bianchi, Giacomo, Pettinari, Matteo, Barbone, Alessandro, Garcia, José P., Shekar, Kiran, Whitman, Glenn, Lorusso, Roberto, and Miranda, Dinis Dos Reis

Abstract

Objectives: Postcardiotomy extracorporeal membrane oxygenation (ECMO) can be initiated intraoperatively or postoperatively based on indications, settings, patient profile, and conditions. The topic of implantation timing only recently gained attention from the clinical community. We compare patient characteristics as well as in-hospital and long-term survival between intraoperative and postoperative ECMO.Methods: The retrospective, multicenter, observational Postcardiotomy Extracorporeal Life Support (PELS-1) study includes adults who required ECMO due to postcardiotomy shock between 2000 and 2020. We compared patients who received ECMO in the operating theater (intraoperative) with those in the intensive care unit (postoperative) on in-hospital and postdischarge outcomes. Results: We studied 2003 patients (women: 41.1%; median age: 65 years; interquartile range [IQR], 55.0-72.0). Intraoperative ECMO patients (n = 1287) compared with postoperative ECMO patients (n = 716) had worse preoperative risk profiles. Cardiogenic shock (45.3%), right ventricular failure (15.9%), and cardiac arrest (14.3%) were the main indications for postoperative ECMO initiation, with cannulation occurring after (median) 1 day (IQR, 1-3 days). Compared with intraoperative application, patients who received postoperative ECMO showed more complications, cardiac reoperations (intraoperative: 19.7%; postoperative: 24.8%, P = .011), percutaneous coronary interventions (intraoperative: 1.8%; postoperative: 3.6%, P = .026), and had greater in-hospital mortality (intraoperative: 57.5%; postoperative: 64.5%, P = .002). Among hospital survivors, ECMO duration was shorter after intraoperative ECMO (median, 104; IQR, 67.8-164.2 hours) compared with postoperative ECMO (median, 139.7; IQR, 95.8-192 hours, P < .001), whereas postdischarge long-term survival was similar between the 2 groups (P = .86). Conclusions: Intraopera

Published
2023

45. Outcomes of Transcatheter Aortic Valve Implantation Comparing Medtronic’s Evolut PRO and Evolut R: A Systematic Review and Meta-Analysis of Observational Studies

Author

Gozdek, Mirosław, primary, Kuźma, Łukasz, additional, Dąbrowski, Emil Julian, additional, Janiak, Michał, additional, Pietrzak, Martyna, additional, Skonieczna, Karolina, additional, Woźnica, Mikołaj, additional, Wydeheft, Lidia, additional, Makhoul, Maged, additional, Matteucci, Matteo, additional, Litwinowicz, Radosław, additional, Kowalówka, Adam, additional, Wańha, Wojciech, additional, Pasierski, Michał, additional, Ronco, Daniele, additional, Massimi, Giulio, additional, Jiritano, Federica, additional, Fina, Dario, additional, Martucci, Gennaro, additional, Raffa, Giuseppe Maria, additional, Suwalski, Piotr, additional, Lorusso, Roberto, additional, Meani, Paolo, additional, and Kowalewski, Mariusz, additional

Published
2023
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