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1. Hypoalbuminemia and Risk of Portal Vein Thrombosis in Cirrhosis

Author

Roberto Cangemi, Valeria Raparelli, Giovanni Talerico, Stefania Basili, Francesco Violi, Palasciano Giuseppe, D’Alitto Felicia, Palmieri Vincenzo Ostilio, Santovito Daniela, Di Michele Dario, Croce Giuseppe, Sacerdoti David, Brocco Silvia, Fasolato Silvano, Cecchetto Lara, Bombonato Giancarlo, Bertoni Michele, Restuccia Tea, Andreozzi Paola, Liguori Maria Livia, Perticone Francesco, Caroleo Benedetto, Perticone Maria, Staltari Orietta, Manfredini Roberto, De Giorgi Alfredo, Averna Maurizio, Giammanco Antonina, Granito Alessandro, Pettinari Irene, Marinelli Sara, Bolondi Luigi, Falsetti Lorenzo, Salvi Aldo, Durante-Mangoni Emanuele, Cesaro Flavio, Farinaro Vincenza, Ragone Enrico, Morana Ignazio, Andriulli Angelo, Ippolito Antonio, Iacobellis Angelo, Niro Grazia, Merla Antonio, Raimondo Giovanni, Maimone Sergio, Cacciola Irene, Varvara Doriana, Drenaggi Davide, Staffolani Silvia, Picardi Antonio, Vespasiani-Gentilucci Umberto, Galati Giovanni, Gallo Paolo, Davì Giovanni, Schiavone Cosima, Santilli Francesca, Tana Claudio, Licata Anna, Soresi Maurizio, Bianchi Giovanni Battista, Carderi Isabella, Pinto Antonio, Tuttolomondo Antonino, Ferrari Giovanni, Gresele Paolo, Fierro Tiziana, Morelli Olivia, Laffi Giacomo, Romanelli Roberto Giulio, Arena Umberto, Stasi Cristina, Gasbarrini Antonio, Gargovich Matteo, Zocco Maria Assunta, Riccardi Laura, Ainora Maria Elena, Capeci William, Martino Giuseppe Pio, Nobili Lorenzo, Cavallo Maurizio, Frugiuele Pierluigi, Greco Antonio, Pietrangelo Antonello, Ventura Paolo, Cuoghi Chiara, Marcacci Matteo, Serviddio Gaetano, Vendemiale Gianluigi, Villani Rosanna, Gargano Ruggiero, Vidili Gianpaolo, Di Cesare Valentina, Masala Maristella, Delitala Giuseppe, Invernizzi Pietro, Di Minno Giovanni, Tufano Antonella, Purrello Francesco, Privitera Graziella, Forgione Alessandra, Curigliano Valentina, Senzolo Marco, Rodríguez-Castro Kryssia Isabel, Giannelli Gianluigi, Serra Carla, Neri Sergio, Pignataro Pietro, Rizzetto Mario, Debernardi Venon Wilma, Svegliati Baroni Gianluca, Bergamaschi Gaetano, Masotti Michela, Costanzo Filippo, Corazza Gino Roberto, Caldwell Stephen Hugh, Angelico Francesco, Del Ben Maria, Napoleone Laura, Polimeni Licia, Proietti Marco, Raparelli Valeria, Romiti Giulio Francesco, Ruscio Eleonora, Severoni Andrea, Talerico Giovanni, Toriello Filippo, and Vestri Annarita

Subjects
Albumin, Cirrhosis, Portal Vein Thrombosis, Diseases of the digestive system. Gastroenterology, RC799-869
Abstract

Background and Aims: Hypoalbuminemia, as defined by serum albumin (SA) levels ≤35 g/L, is associated to venous and arterial thrombosis in general population and in patients at risk of cardiovascular disease. It is unknown if SA ≤35 g/L is also associated to portal vein thrombosis (PVT) in cirrhosis. Methods: Cirrhotic patients enrolled in the Portal vein thrombosis Relevance On Liver cirrhosis: Italian Venous thrombotic Events Registry (PRO-LIVER) study (n = 753), were followed-up for 2 years to assess the risk of PVT, that was diagnosed by Doppler ultrasonography. Child-Pugh classes, Model for End-Stage Liver Disease score, presence of hepatocellular carcinoma and laboratory variables including SA, D-dimer, and high-sensitivity C-reactive protein (hs-CRP) were measured at baseline. Results: SA ≤35 g/L was detected in 52% of patients. A logistic multivariate regression analysis showed that higher Child-Pugh class, hepatocellular carcinoma and thrombocytopenia were significantly associated to SA ≤35 g/L. In a subgroup of patients where data regarding hs-CRP and D-dimer were available, SA ≤35 g/L was inversely associated with hs-CRP and D-dimer. During the follow-up, a total of 61 patients experienced PVT. A Kaplan Meier survival analysis showed SA ≤35 g/L was associated to increased risk of PVT compared to SA >35 g/L (P = .005). A multivariate Cox proportional hazards regression analysis showed that male sex, lower platelet count, and SA ≤35 g/L remained associated to PVT after adjusting for confounding factors. Conclusion: Cirrhotic patients with SA ≤35 g/L are at higher risk of experiencing PVT compared to those with SA >35 g/L and could be considered as potential candidates to anticoagulant prophylaxis for PVT prevention.

Published
2024
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3. Efficacy and safety of lusutrombopag in a real-world Italian series of cirrhotic patients with severe thrombocytopenia undergoing invasive procedures: the Reality study

Author

Gallo, Paolo, primary, De Vincentis, Antonio, additional, Palitti, Valeria Pace, additional, Russello, Maurizio, additional, Vignone, Anthony, additional, Alvaro, Domenico, additional, Tortora, Raffaella, additional, Biolato, Marco, additional, Pompili, Maurizio, additional, Calvaruso, Vincenza, additional, Veneziano, Marzia, additional, Rosato, Valerio, additional, Claar, Ernesto, additional, Villani, Rosanna, additional, Izzi, Antonio, additional, Cozzolongo, Raffaele, additional, Distefano, Marco, additional, Messina, Vincenzo, additional, Ragone, Enrico, additional, Sacco, Rodolfo, additional, Cacciatore, Pierluigi, additional, Moretti, Alessandra, additional, Terracciani, Francesca, additional, Picardi, Antonio, additional, and Gentilucci, Umberto Vespasiani, additional

Published
2023
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5. Development of a risk score to predict portal vein tumor thrombosis in patients with hepatocellular carcinoma.

Author

Tortora, Raffaella, Farella, Nunzia, Morisco, Filomena, Coppola, Carmine, Izzo, Francesco, Salomone Megna, Angelo, Federico, Alessandro, Messina, Vincenzo, Nardone, Gerardo, Piai, Guido, Ragone, Enrico, Adinolfi, Luigi Elio, D'Adamo, Giuseppe, Stanzione, Maria, Francica, Giampiero, Torre, Pietro, De Girolamo, Vincenzo, Coppola, Nicola, Guarino, Maria, and Dallio, Marcello

Published
2023
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6. Type 2 diabetes combined with portal vein tumor thrombosis worsens prognosis in patients with hepatocellular carcinoma

Author

Angrisani, Debora, primary, Guarracino, Marco, additional, Farella, Nunzia, additional, Morisco, Filomena, additional, Coppola, Carmine, additional, Izzo, Francesco, additional, Megna, Angelo Salomone, additional, Federico, Alessandro, additional, Messina, Vincenzo, additional, Nardone, Gerardo, additional, Piai, Guido, additional, Ragone, Enrico, additional, Adinolfi, Luigi Elio, additional, D’Adamo, Giuseppe, additional, Stanzione, Maria, additional, Francica, Giampiero, additional, Persico, Marcello, additional, De Girolamo, Vincenzo, additional, Nicola, Coppola, additional, Rocco, Lucia, additional, Di Costanzo, Giovan Giuseppe, additional, and Tortora, Raffaella, additional

Published
2022
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7. TOP-085 Final results from the italian real-world experience on lusutrombopag treatment in cirrhotic patients with severe thrombocytopenia: insights from the reality study

Author

Gallo, Paolo, De Vincentis, Antonio, Pace Palitti, Valeria, Russello, Maurizio, Vignone, Anthony, Alvaro, Domenico, Tortora, Raffaella, biolato, marco, Pompili, Maurizio, Calvaruso, Vincenza, Veneziano, Marzia, Tizzani, Marco, Frigo, Francesco, Caneglias, Alessandro, Marcantonio, Gesualdo, Marzano, Alfredo, Rosato, Valerio, Claar, Ernesto, Villani, Rosanna, Izzi, Antonio, Cozzolongo, Raffaele, Airoldi, Aldo, Mazzarelli, Chiara, Distefano, Marco, Iegri, Claudia, Fagiuoli, Stefano, Messina, Vincenzo, Ragone, Enrico, Sacco, Rodolfo, Cacciatore, Pierluigi, Masutti, Flora, Saveria Crocè, Lory, Moretti, Alessandra, Terracciani, Francesca, Falcomata, Andrea, Di Pasquale, Giulia, Flagiello, Valentina, Picardi, Antonio, and Vespasiani-Gentilucci, Umberto

Published
2024
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10. Percutaneous irreversible electroporation in combination with radiofrequency ablation in the treatment of non-resectable hepatocellular carcinoma: A case report

Author

Rossi Giuseppe, Ragone Enrico, Sanges Federica, and Scarica Sabrina

Subjects
medicine.medical_specialty, Percutaneous, Resectable Hepatocellular Carcinoma, Radiofrequency ablation, law, business.industry, General Engineering, Medicine, Irreversible electroporation, Radiology, business, law.invention
Abstract

Introduction: There are more option of treatments of hepatocellular carcinoma (HCC), that is currently the sixth most common cancer worldwide. As only 10–20% of patients are candidates for surgery (resection or transplantation), ablative therapies such as Radiofrequency (RF) and Microwave (MW) ablation are both widely used techniques, but tumors adjacent to heat-sensitive structures such as the gallbladder, major bile ducts, portal vein, and hepatic veins are difficult to destroy. Irreversible electroporation (IRE) is a new non-thermal ablation technique for pancreatic and liver tumors that generates electrical fields leading to cell death through apoptosis. In this way IRE prevents collateral damage to other tissues, such as blood vessels, bile ducts, nerves, gallbladder and other vital organs which often occur in thermal ablation techniques. Case Report: We report the treatment of an inoperable HCC with a maximum diameter of 40 mm in left lobe at the 4th hepatic segment, adjacent to the gallbladder in a 75-year-old female with hepatitis C–related cirrhosis. It was used for the first time a dual thermal and nonthermal ablative technique: ultrasound–guided irreversible electroporation ablation (IRE) following ultrasound–guided radiofrequency ablation (RFA) in the same session. We got complete response at 1, 3 and 6 months follow-up without evidenced of local tumor progression or metastatic disease. Conclusion: Combination therapy plays an important role in the treatment of unresectable HCC, because near vital structures, but additional research is necessary to assess further the safety, efficacy and long-term outcomes for this combination therapy.

Published
2018

11. OS-036 - Efficacy and safety of lusutrombopag in a real-world Italian series of cirrhotic patients with severe thrombocytopenia undergoing invasive procedures: the Reality study

Author

Gallo, Paolo, De Vincentis, Antonio, Palitti, Valeria Pace, Russello, Maurizio, Vignone, Anthony, Alvaro, Domenico, Tortora, Raffaella, Biolato, Marco, Pompili, Maurizio, Calvaruso, Vincenza, Veneziano, Marzia, Rosato, Valerio, Claar, Ernesto, Villani, Rosanna, Izzi, Antonio, Cozzolongo, Raffaele, Distefano, Marco, Messina, Vincenzo, Ragone, Enrico, Sacco, Rodolfo, Cacciatore, Pierluigi, Moretti, Alessandra, Terracciani, Francesca, Picardi, Antonio, and Gentilucci, Umberto Vespasiani

Published
2023
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15. Serum Albumin Is Inversely Associated With Portal Vein Thrombosis in Cirrhosis

Author

Basili, Stefania, Carnevale, Roberto, Nocella, Cristina, Bartimoccia, Simona, Raparelli, Valeria, Talerico, Giovanni, Stefanini, Lucia, Romiti, Giulio F, Perticone, Francesco, Corazza, Gino R, Piscaglia, Fabio, Pietrangelo, Antonello, Violi, Francesco, and PRO-LIVER collaborators, : Ainora Maria Elena, Andreozzi, Paola, Andriulli, Angelo, Angelico, Francesco, Angelico, Mario, Figliomeni, Antonio, Anzaldi, Massimiliano, Arena, Umberto, Averna, Maurizio, Barone, Milena, Bazzini, Cristina, Bergamaschi, Gaetano, Bertoni, Michele, Bianchi Giovanni Battista, Bianchi Paola Ilaria, Boari, Benedetta, Bombonato, Giancarlo, Bracco, Christian, Brocco, Silvia, Buonauro, Agostino, Buttà, Carmelo, Buzzetti, Elena, Cacciola, Irene, Calabria, Stefano, Cangemi, Roberto, Capeci, William, Caradio, Federica, Carderi, Isabella, Carleo, Pietro, Caroleo, Benedetto, Carrabba Maria Domenica, Castorani, Luigi, Cavallo, Maurizio, Cecchetto, Lara, Cesaro, Flavio, Cicco, Sebastiano, Cimini, Claudia, Colombo Barbara Maria, Corradini, Elena, Corrao, Salvatore, Costantino, Giorgio, Costanzo, Filippo, Croce, Giuseppe, Cuoghi, Chiara, Curigliano, Valentina, D’Alitto, Felicia, D’Amico, Gennaro, De Franchis Roberto, De Giorgi Alfredo, De Vuono Stefano, Debernardi Venon Wilma, Del Ben Maria, Del Corso Lisette, Delitala, Giuseppe, Denegri, Andrea, Di Cesare Valentina, Di Giosia Paolo, Di Michele Dario, Di Minno Giovanni, Donnarumma, Emilia, Drenaggi, Davide, Durante-Mangoni, Emanuele, Falsetti, Lorenzo, Farcomeni, Alessio, Farinaro, Vincenza, Fasolato, Silvano, Ferrari, Giovanni, Fierro, Tiziana, Forgione, Alessandra, Frugiuele, Pierluigi, Galati, Giovanni, Gallo, Paolo, Garcovich, Matteo, Gargano, Ruggiero, Gasbarrini, Antonio, Gatta, Angelo, Giammanco, Antonina, Giannelli, Gianluigi, Giorgini, Paolo, Gobbi, Paolo, Granito, Alessandro, Grassi, Davide, Greco, Antonio, Grembiale, Alessandro, Gresele, Paolo, Hijazi, Daniel, Iacobellis, Angelo, Iamele, Luigi, Invernizzi, Pietro, Ippolito, Antonio, Laffi, Giacomo, Licata, Anna, Liguori Maria Livia, Lorusso, Giusi, Maimone, Sergio, Manfredini, Roberto, Marcacci, Matteo, Marchese, Alessandra, Marinelli, Sara, Marra Alberto Maria, Martino Giuseppe Pio, Masala, Maristella, Masotti, Michela, Merla, Antonio, Miceli, Giuseppe, Montebianco Abenavoli Ludovico, Morana, Ignazio, Morelli, Olivia, Murgia, Giuseppe, Naccarato, Paola, Neri, Sergio, Niro, Grazia, Nobili, Lorenzo, Padula, Donatella, Palasciano, Giuseppe, Palmieri Vincenzo Ostilio, Pastori, Daniele, Pattoneri, Paolo, Perego, Francesca, Perticone, Maria, Pesce, Paola, Petramala, Luigi, Pettinari, Irene, Piano, Salvatore, Picardi, Antonio, Pignataro Francesca Serena, Pignataro, Pietro, Pignatelli, Pasquale, Pinna, Miriam, Pinto, Antonio, Pinto, Daniela, Polimeni, Licia, Pretti, Vincenzo, Privitera, Graziella, Proietti, Marco, Pucci, Giacomo, Purrello, Francesco, Ragone, Enrico, Raimondo, Giovanni, Restuccia, Tea, Riccardi, Laura, Rizzetto, Mario, Rodríguez-Castro Kryssia Isabel, Romanelli Roberto Giulio, Ruscio, Eleonora, Sacerdoti, David, Salinaro, Francesco, Salvi, Aldo, Salzano, Andrea, Santangelo, Giuseppe, Santarossa, Claudia, Santilli, Francesca, Santovito, Daniela, Scarpini, Francesca, Schiavone, Cosima, Scicali, Roberto, Senzolo, Marco, Serra, Carla, Serviddio, Gaetano, Sirico, Domenico, Soresi, Maurizio, Sperduti, Nicolò, Staffolani, Silvia, Staltari, Orietta, Stasi, Cristina, Suppressa, Patrizia, Svegliati Baroni Gianluca, Talia, Michela, Tana, Claudio, Tassone Eliezer Joseph, Todisco, Tommaso, Toriello, Filippo, Torres, Daniele, Traversa, Matteo, Tripepi, Giovanni, Tufano, Antonella, Tuttolomondo, Antonino, Varvara, Doriana, Vazzana, Natale, Vecchio Claudia Rita, Vendemiale, Gianluigi, Ventura, Paolo, Vespasiani-Gentilucci, Umberto, Vettore, Elia, Vidili, Gianpaolo, Villani, Rosanna, Vincenzo, Ronca, Visioli, Giacomo, Vitale, Francesco, Zocco Maria, Assunta., and Stefania Basili, Roberto Carnevale, Cristina Nocella, Simona Bartimoccia, Valeria Raparelli, Giovanni Talerico, Lucia Stefanini, Giulio F. Romiti, Francesco Perticone, Gino R. Corazza, Fabio Piscaglia, Antonello Pietrangelo, Francesco Violi, PRO-LIVER Collaborators, Alessandro Granito

Subjects
medicine.medical_specialty, Cirrhosis, Isoprostane, Urinary system, serum albumin, Serum albumin, Gastroenterology, NO, chemistry.chemical_compound, Internal medicine, Medicine, Platelet, portal vein thrombosis, Platelet activation, Portal vein thrombosis, Albumin, risk, protein, albumin, risk, Hepatology, biology, business.industry, cirrhosis, Albumin, Original Articles, medicine.disease, Portal vein thrombosis, chemistry, biology.protein, Original Article, protein, albumin, portal vein thrombosis, cirrhosis, business
Abstract

We analyzed whether serum albumin is independently associated with portal vein thrombosis (PVT) in liver cirrhosis (LC) and if a biologic plausibility exists. This study was divided into three parts. In part 1 (retrospective analysis), 753 consecutive patients with LC with ultrasound‐detected PVT were retrospectively analyzed. In part 2, 112 patients with LC and 56 matched controls were entered in the cross‐sectional study. In part 3, 5 patients with cirrhosis were entered in the in vivo study and 4 healthy subjects (HSs) were entered in the in vitro study to explore if albumin may affect platelet activation by modulating oxidative stress. In the 753 patients with LC, the prevalence of PVT was 16.7%; logistic analysis showed that only age (odds ratio [OR], 1.024; P = 0.012) and serum albumin (OR, −0.422; P = 0.0001) significantly predicted patients with PVT. Analyzing the 112 patients with LC and controls, soluble clusters of differentiation (CD)40‐ligand (P = 0.0238), soluble Nox2‐derived peptide (sNox2‐dp; P < 0.0001), and urinary excretion of isoprostanes (P = 0.0078) were higher in patients with LC. In LC, albumin was correlated with sCD40L (Spearman’s rank correlation coefficient [rs], −0.33; P < 0.001), sNox2‐dp (rs, −0.57; P < 0.0001), and urinary excretion of isoprostanes (rs, −0.48; P < 0.0001) levels. The in vivo study showed a progressive decrease in platelet aggregation, sNox2‐dp, and urinary 8‐iso prostaglandin F2α‐III formation 2 hours and 3 days after albumin infusion. Finally, platelet aggregation, sNox2‐dp, and isoprostane formation significantly decreased in platelets from HSs incubated with scalar concentrations of albumin. Conclusion: Low serum albumin in LC is associated with PVT, suggesting that albumin could be a modulator of the hemostatic system through interference with mechanisms regulating platelet activation.

Published
2019

16. SAT599 - Type 2 diabetes combined with portal vein tumor thrombosis worsens prognosis in patients with hepatocellular carcinoma

Author

Angrisani, Debora, Guarracino, Marco, Farella, Nunzia, Morisco, Filomena, Coppola, Carmine, Izzo, Francesco, Megna, Angelo Salomone, Federico, Alessandro, Messina, Vincenzo, Nardone, Gerardo, Piai, Guido, Ragone, Enrico, Adinolfi, Luigi Elio, D’Adamo, Giuseppe, Stanzione, Maria, Francica, Giampiero, Persico, Marcello, De Girolamo, Vincenzo, Nicola, Coppola, Rocco, Lucia, Di Costanzo, Giovan Giuseppe, and Tortora, Raffaella

Published
2022
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18. Erratum to: Portal vein thrombosis relevance on liver cirrhosis: Italian Venous Thrombotic Events Registry (Intern Emerg Med, 10.1007/s11739-016-1416-8)

Author

Violi F., Corazza G. R., Caldwell S. H., Perticone F., Gatta A., Angelico M., Farcomeni A., Masotti M., Napoleone L., Vestri A., Raparelli V., Basili S., PRO-LIVER Collaborators Palasciano Giuseppe, D’Alitto Felicia, Palmieri Vincenzo Ostilio, Santovito Daniela, Di Michele Dario, Croce Giuseppe, Sacerdoti David, Brocco Silvia, Fasolato Silvano, Cecchetto Lara, Bombonato Giancarlo, Bertoni Michele, Restuccia Tea, Andreozzi Paola, Liguori Maria Livia, Perticone Francesco, Caroleo Benedetto, Perticone Maria, Staltari Orietta, Manfredini Roberto, De Giorgi Alfredo, Averna Maurizio, Giammanco Antonina, Granito Alessandro, Pettinari Irene, Marinelli Sara, Bolondi Luigi, Falsetti Lorenzo, Salvi Aldo, Durante-Mangoni Emanuele, Cesaro Flavio, Farinaro Vincenza, Ragone Enrico, Morana Ignazio, Andriulli Angelo, Ippolito Antonio, Iacobellis Angelo, Niro Grazia, Merla Antonio, Raimondo Giovanni, Maimone Sergio, Cacciola Irene, Varvara Doriana, Drenaggi Davide, Staffolani Silvia, Picardi Antonio, Vespasiani-Gentilucci Umberto, Galati Giovanni, Gallo Paolo, Davı` Giovanni, Schiavone Cosima, Santilli Francesca, Tana Claudio, Licata Anna, Soresi Maurizio, Bianchi Giovanni Battista, Carderi Isabella, Pinto Antonio, Tuttolomondo Antonino, Ferrari Giovanni, Gresele Paolo, Fierro Tiziana, Morelli Olivia, Laffi Giacomo, Romanelli Roberto Giulio, Arena Umberto, Stasi Cristina, Gasbarrini Antonio, Gargovich Matteo, Zocco Maria Assunta, Riccardi Laura, Ainora Maria Elena, Capeci William, Martino Giuseppe Pio, Nobili Lorenzo, Cavallo Maurizio, Frugiuele Pierluigi, Greco Antonio, Pietrangelo Antonello, Ventura Paolo, Cuoghi Chiara, Marcacci Matteo, Serviddio Gaetano, Vendemiale Gianluigi, Villani Rosanna, Gargano Ruggiero, Vidili Gianpaolo, Di Cesare Valentina, Masala Maristella, Delitala Giuseppe, Invernizzi Pietro, Di Minno Giovanni, Tufano Antonella, Purrello Francesco, Privitera Graziella, Forgione Alessandra, Curigliano Valentina, Senzolo Marco, Rodrıguez-Castro Kryssia Isabel, Giannelli Gianluigi, Serra Carla, Neri Sergio, Pignataro Pietro, Rizzetto Mario, Debernardi Venon Wilma, Svegliati Baroni Gianluca, Bergamaschi Gaetano, Masotti Michela, Costanzo Filippo, Angelico Francesco, Del Ben Maria, Napoleone Laura, Polimeni Licia, Raparelli Valeria, Talerico Giovanni, Proietti Marco, Romiti Giulio Francesco, Ruscio Eleonora, Toriello Filippo, Violi F., Corazza G.R., Caldwell S.H., Perticone F., Gatta A., Angelico M., Farcomeni A., Masotti M., Napoleone L., Vestri A., Raparelli V., Basili S., and PRO-LIVER Collaborators Palasciano Giuseppe, D’Alitto Felicia, Palmieri Vincenzo Ostilio, Santovito Daniela, Di Michele Dario, Croce Giuseppe, Sacerdoti David, Brocco Silvia, Fasolato Silvano, Cecchetto Lara, Bombonato Giancarlo, Bertoni Michele, Restuccia Tea, Andreozzi Paola, Liguori Maria Livia, Perticone Francesco, Caroleo Benedetto, Perticone Maria, Staltari Orietta, Manfredini Roberto, De Giorgi Alfredo, Averna Maurizio, Giammanco Antonina, Granito Alessandro, Pettinari Irene, Marinelli Sara, Bolondi Luigi, Falsetti Lorenzo, Salvi Aldo, Durante-Mangoni Emanuele, Cesaro Flavio, Farinaro Vincenza, Ragone Enrico, Morana Ignazio, Andriulli Angelo, Ippolito Antonio, Iacobellis Angelo, Niro Grazia, Merla Antonio, Raimondo Giovanni, Maimone Sergio, Cacciola Irene, Varvara Doriana, Drenaggi Davide, Staffolani Silvia, Picardi Antonio, Vespasiani-Gentilucci Umberto, Galati Giovanni, Gallo Paolo, Davı` Giovanni, Schiavone Cosima, Santilli Francesca, Tana Claudio, Licata Anna, Soresi Maurizio, Bianchi Giovanni Battista, Carderi Isabella, Pinto Antonio, Tuttolomondo Antonino, Ferrari Giovanni, Gresele Paolo, Fierro Tiziana, Morelli Olivia, Laffi Giacomo, Romanelli Roberto Giulio, Arena Umberto, Stasi Cristina, Gasbarrini Antonio, Gargovich Matteo, Zocco Maria Assunta, Riccardi Laura, Ainora Maria Elena, Capeci William, Martino Giuseppe Pio, Nobili Lorenzo, Cavallo Maurizio, Frugiuele Pierluigi, Greco Antonio, Pietrangelo Antonello, Ventura Paolo, Cuoghi Chiara, Marcacci Matteo, Serviddio Gaetano, Vendemiale Gianluigi, Villani Rosanna, Gargano Ruggiero, Vidili Gianpaolo, Di Cesare Valentina, Masala Maristella, Delitala Giuseppe, Invernizzi Pietro, Di Minno Giovanni, Tufano Antonella, Purrello Francesco, Privitera Graziella, Forgione Alessandra, Curigliano Valentina, Senzolo Marco, Rodrıguez-Castro Kryssia Isabel, Giannelli Gianluigi, Serra Carla, Neri Sergio, Pignataro Pietro, Rizzetto Mario, Debernardi Venon Wilma, Svegliati Baroni Gianluca, Bergamaschi Gaetano, Masotti Michela, Costanzo Filippo, Angelico Francesco, Del Ben Maria, Napoleone Laura, Polimeni Licia, Raparelli Valeria, Talerico Giovanni, Proietti Marco, Romiti Giulio Francesco, Ruscio Eleonora, Toriello Filippo

Subjects
Splanchnic venous thrombosis Anticoagulants Liver failure Hepatocellular carcinoma Esophageal varices
Abstract

In the original publication, the second author name was incorrectly published as Roberto Gino Corazza. The correct name should read as “Gino Roberto Corazza”. Also, the PRO-LIVER Study Collaborator, Dr. Gabriella Carnevale Maffè has not been included in the Appendix by mistake. The name of Dr. Carnevale Maffe` should read in the Appendix as follows: Bergamaschi Gaetano, Carnevale Maffè Gabriella, Masotti Michela, Costanzo Filippo (I° Clinica Medica, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Italy).

Published
2016

21. Validated Risk Score for Predicting 6‐Month Mortality in Infective Endocarditis

Author

Park, Lawrence P., primary, Chu, Vivian H., additional, Peterson, Gail, additional, Skoutelis, Athanasios, additional, Lejko‐Zupa, Tatjana, additional, Bouza, Emilio, additional, Tattevin, Pierre, additional, Habib, Gilbert, additional, Tan, Ren, additional, Gonzalez, Javier, additional, Altclas, Javier, additional, Edathodu, Jameela, additional, Fortes, Claudio Querido, additional, Siciliano, Rinaldo Focaccia, additional, Pachirat, Orathai, additional, Kanj, Souha, additional, Wang, Andrew, additional, Clara, Liliana, additional, Sanchez, Marisa, additional, Casabé, José, additional, Cortes, Claudia, additional, Nacinovich, Francisco, additional, Fernandez Oses, Pablo, additional, Ronderos, Ricardo, additional, Sucari, Adriana, additional, Thierer, Jorge, additional, Kogan, Silvia, additional, Spelman, Denis, additional, Athan, Eugene, additional, Harris, Owen, additional, Kennedy, Karina, additional, Gordon, David, additional, Papanicolas, Lito, additional, Korman, Tony, additional, Kotsanas, Despina, additional, Dever, Robyn, additional, Jones, Phillip, additional, Konecny, Pam, additional, Lawrence, Richard, additional, Rees, David, additional, Ryan, Suzanne, additional, Feneley, Michael P., additional, Harkness, John, additional, Post, Jeffrey, additional, Reinbott, Porl, additional, Gattringer, Rainer, additional, Wiesbauer, Franz, additional, Andrade, Adriana Ribas, additional, de Brito, Ana Cláudia Passos, additional, Guimarães, Armenio Costa, additional, Grinberg, Max, additional, Mansur, Alfredo José, additional, Strabelli, Tania Mara Varejao, additional, Vieira, Marcelo Luiz Campos, additional, de Medeiros Tranchesi, Regina Aparecida, additional, Paiva, Marcelo Goulart, additional, de Oliveira Ramos, Auristela, additional, Weksler, Clara, additional, Ferraiuoli, Giovanna, additional, Golebiovski, Wilma, additional, Lamas, Cristiane, additional, Karlowsky, James A., additional, Keynan, Yoav, additional, Morris, Andrew M., additional, Rubinstein, Ethan, additional, Jones, Sandra Braun, additional, Garcia, Patricia, additional, Fica, Alberto, additional, Mella, Rodrigo Montagna, additional, Fernandez, Ricardo, additional, Franco, Liliana, additional, Jaramillo, Astrid Natalia, additional, Barsic, Bruno, additional, Bukovski, Suzana, additional, Krajinovic, Vladimir, additional, Pangercic, Ana, additional, Rudez, Igor, additional, Vincelj, Josip, additional, Freiberger, Tomas, additional, Pol, Jiri, additional, Zaloudikova, Barbora, additional, Ashour, Zainab, additional, El Kholy, Amani, additional, Mishaal, Marwa, additional, Osama, Dina, additional, Rizk, Hussien, additional, Aissa, Neijla, additional, Alauzet, Corentine, additional, Alla, Francois, additional, Campagnac, Catherine, additional, Doco‐Lecompte, Thanh, additional, Selton‐Suty, Christine, additional, Casalta, Jean‐Paul, additional, Fournier, Pierre‐Edouard, additional, Raoult, Didier, additional, Thuny, Franck, additional, Delahaye, Francois, additional, Delahaye, Armelle, additional, Vandenesch, Francois, additional, Donal, Erwan, additional, Donnio, Pierre Yves, additional, Flecher, Erwan, additional, Michelet, Christian, additional, Revest, Matthieu, additional, Chevalier, Florent, additional, Jeu, Antoine, additional, Rémadi, Jean Paul, additional, Rusinaru, Dan, additional, Tribouilloy, Christophe, additional, Bernard, Yvette, additional, Chirouze, Catherine, additional, Hoen, Bruno, additional, Leroy, Joel, additional, Plesiat, Patrick, additional, Naber, Christoph, additional, Neuerburg, Carl, additional, Mazaheri, Bahram, additional, Athanasia, Sophia, additional, Deliolanis, Ioannis, additional, Giamarellou, Helen, additional, Thomas, Tsaganos, additional, Giannitsioti, Efthymia, additional, Mylona, Elena, additional, Paniara, Olga, additional, Papanicolaou, Konstantinos, additional, Pyros, John, additional, Papanikolaou, Konstantinos, additional, Sharma, Gautam, additional, Francis, Johnson, additional, Nair, Lathi, additional, Thomas, Vinod, additional, Venugopal, Krishnan, additional, Hannan, Margaret M., additional, Hurley, John P., additional, Cahan, Amos, additional, Gilon, Dan, additional, Israel, Sarah, additional, Korem, Maya, additional, Strahilevitz, Jacob, additional, Durante‐Mangoni, Emanuele, additional, Mattucci, Irene, additional, Pinto, Daniela, additional, Agrusta, Federica, additional, Senese, Alessandra, additional, Ragone, Enrico, additional, Utili, Riccardo, additional, Cecchi, Enrico, additional, De Rosa, Francesco, additional, Forno, Davide, additional, Imazio, Massimo, additional, Trinchero, Rita, additional, Grossi, Paolo, additional, Lattanzio, Mariangela, additional, Toniolo, Antonio, additional, Goglio, Antonio, additional, Raglio, Annibale, additional, Ravasio, Veronica, additional, Rizzi, Marco, additional, Suter, Fredy, additional, Carosi, Giampiero, additional, Magri, Silvia, additional, Signorini, Liana, additional, Kanafani, Zeina, additional, Kanj, Souha S., additional, Sharif‐Yakan, Ahmad, additional, Abidin, Imran, additional, Tamin, Syahidah Syed, additional, Martínez, Eduardo Rivera, additional, Soto Nieto, Gabriel Israel, additional, van der Meer, Jan T.M., additional, Chambers, Stephen, additional, Holland, David, additional, Morris, Arthur, additional, Raymond, Nigel, additional, Read, Kerry, additional, Murdoch, David R., additional, Dragulescu, Stefan, additional, Ionac, Adina, additional, Mornos, Cristian, additional, Butkevich, O.M., additional, Chipigina, Natalia, additional, Kirill, Ozerecky, additional, Vadim, Kulichenko, additional, Vinogradova, Tatiana, additional, Halim, Magid, additional, Liew, Yee‐Yun, additional, Tan, Ru‐San, additional, Logar, Mateja, additional, Mueller‐Premru, Manica, additional, Commerford, Patrick, additional, Commerford, Anita, additional, Deetlefs, Eduan, additional, Hansa, Cass, additional, Ntsekhe, Mpiko, additional, Almela, Manuel, additional, Armero, Yolanda, additional, Azqueta, Manuel, additional, Castañeda, Ximena, additional, Cervera, Carlos, additional, Falces, Carlos, additional, Garcia‐de‐la‐Maria, Cristina, additional, Fita, Guillermina, additional, Gatell, Jose M., additional, Heras, Magda, additional, Llopis, Jaime, additional, Marco, Francesc, additional, Mestres, Carlos A., additional, Miró, José M., additional, Moreno, Asuncion, additional, Ninot, Salvador, additional, Paré, Carlos, additional, Pericas, Juan M., additional, Ramirez, Jose, additional, Rovira, Irene, additional, Sitges, Marta, additional, Anguera, Ignasi, additional, Font, Bernat, additional, Guma, Joan Raimon, additional, Bermejo, Javier, additional, Garcia Fernández, Miguel Angel, additional, Gonzalez‐Ramallo, Victor, additional, Marín, Mercedes, additional, Muñoz, Patricia, additional, Pedromingo, Miguel, additional, Roda, Jorge, additional, Rodríguez‐Créixems, Marta, additional, Solis, Jorge, additional, Almirante, Benito, additional, Fernandez‐Hidalgo, Nuria, additional, Tornos, Pilar, additional, de Alarcón, Arístides, additional, Parra, Ricardo, additional, Alestig, Eric, additional, Johansson, Magnus, additional, Olaison, Lars, additional, Snygg‐Martin, Ulrika, additional, Pachirat, Pimchitra, additional, Pussadhamma, Burabha, additional, Senthong, Vichai, additional, Casey, Anna, additional, Elliott, Tom, additional, Lambert, Peter, additional, Watkin, Richard, additional, Eyton, Christina, additional, Klein, John L., additional, Bradley, Suzanne, additional, Kauffman, Carol, additional, Bedimo, Roger, additional, Corey, G. Ralph, additional, Crowley, Anna Lisa, additional, Douglas, Pamela, additional, Drew, Laura, additional, Fowler, Vance G., additional, Holland, Thomas, additional, Lalani, Tahaniyat, additional, Mudrick, Daniel, additional, Samad, Zaniab, additional, Sexton, Daniel, additional, Stryjewski, Martin, additional, Woods, Christopher W., additional, Lerakis, Stamatios, additional, Cantey, Robert, additional, Steed, Lisa, additional, Wray, Dannah, additional, Dickerman, Stuart A., additional, Bonilla, Hector, additional, DiPersio, Joseph, additional, Salstrom, Sara‐Jane, additional, Baddley, John, additional, Patel, Mukesh, additional, Stancoven, Amy, additional, Levine, Donald, additional, Riddle, Jonathan, additional, Rybak, Michael, additional, Cabell, Christopher H., additional, Baloch, Khaula, additional, Dixon, Christy C., additional, Harding, Tina, additional, Jones‐Richmond, Marian, additional, Sanderford, Bob, additional, Stafford, Judy, additional, Anstrom, Kevin, additional, Bayer, Arnold S., additional, Karchmer, A. W., additional, Sexton, Daniel J., additional, Chu, Vivian, additional, Durack, David T., additional, Eykyn, Susannah, additional, and Moreillon, Phillipe, additional

Published
2016
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22. Influence of the timing of cardiac surgery on the outcome of patients with infective endocarditis and stroke

Author

Barsic, Bruno, Dickerman, Stuart, Krajinovic, Vladimir, Pappas, Paul, Altclas, Javier, Carosi, Giampiero, Casabé, José H., Chu, Vivian H., Delahaye, Francois, Edathodu, Jameela, Fortes, Claudio Querido, Olaison, Lars, Pangercic, Ana, Patel, Mukesh, Rudez, Igor, Tamin, Syahidah Syed, Vincelj, Josip, Bayer, Arnold S., Wang, Andrew, Clara, Liliana, Sanchez, Marisa, Nacinovich, Francisco, Oses, Pablo Fernandez, Ronderos, Ricardo, Sucari, Adriana, Thierer, Jorge, Casabé, José, Cortes, Claudia, Kogan, Silvia, Spelman, Denis, Athan, Eugene, Harris, Owen, Kennedy, Karina, Tan, Ren, Gordon, David, Papanicolas, Lito, Eisen, Damon, Grigg, Leeanne, Street, Alan, Korman, Tony, Kotsanas, Despina, Dever, Robyn, Jones, Phillip, Konecny, Pam, Lawrence, Richard, Rees, David, Ryan, Suzanne, Feneley, Michael P., Harkness, John, Post, Jeffrey, Reinbott, Porl, Gattringer, Rainer, Wiesbauer, Franz, Andrade, Adriana Ribas, De Brito, Ana Cláudia Passos, Guimarães, Armenio Costa, Grinberg, Max, Mansur, Alfredo José, Siciliano, Rinaldo Focaccia, Strabelli, Tania Mara Varejao, Vieira, Marcelo Luiz Campos, De Medeiros Tranchesi, Regina Aparecida, Paiva, Marcelo Goulart, De Oliveira Ramos, Auristela, Ferraiuoli, Giovanna, Golebiovski, Wilma, Lamas, Cristiane, Santos, Marisa, Weksler, Clara, Karlowsky, James A., Keynan, Yoav, Morris, Andrew M., Rubinstein, Ethan, Jones, Sandra Braun, Garcia, Patricia, Cereceda, M., Fica, Alberto, Mella, Rodrigo Montagna, Bukovski, Suzana, Freiberger, Tomas, Pol, Jiri, Zaloudikova, Barbora, Ashour, Zainab, Kholy, Amani El, Mishaal, Marwa, Rizk, Hussien, Aissa, Neijla, Alauzet, Corentine, Alla, Francois, Campagnac, Catherine, Doco Lecompte, Thanh, Selton Suty, Christine, Casalta, Jean Paul, Fournier, Pierre Edouard, Habib, Gilbert, Raoult, Didier, Thuny, Franck, Delahaye, Armelle, Vandenesch, Francois, Donal, Erwan, Donnio, Pierre Yves, Michelet, Christian, Revest, Matthieu, Tattevin, Pierre, Violette, Jérémie, Chevalier, Florent, Jeu, Antoine, Rusinaru, Dan, Sorel, Claire, Tribouilloy, Christophe, Bernard, Yvette, Chirouze, Catherine, Hoen, Bruno, Leroy, Joel, Plesiat, Patrick, Naber, Germa Christoph, Neuerburg, Carl, Mazaheri, Bahram, Naber, Christoph, Athanasia, Sofia, Giannitsioti, Efthymia, Mylona, Elena, Paniara, Olga, Papanicolaou, Konstantinos, Pyros, John, Skoutelis, Athanasios, Sharma, Gautam, Francis, Johnson, Nair, Lathi, Thomas, D. M. Vinod, Venugopal, Krishnan, Hannan, Margaret, Hurley, John, Cahan, Amos, Gilon, Dan, Israel, Sarah, Korem, Maya, Strahilevitz, Jacob, Tripodi, Marie Françoise, Casillo, Roberta, Cuccurullo, Susanna, Dialetto, Giovanni, Durante Mangoni, Emanuele, Irene, Mattucci, Ragone, Enrico, Utili, Riccardo, Cecchi, Enrico, Rosa, Francesco De, Forno, Davide, Imazio, Massimo, Trinchero, Rita, Tebini, Alessandro, Grossi, PAOLO ANTONIO, Lattanzio, Mariangela, Toniolo, Antonio, Goglio, Antonio, Raglio, Annibale, Ravasio, Veronica, Rizzi, Marco, Suter, Fredy, Magri, Silvia, Signorini, Liana, Baban, Tania, Kanafani, Zeina, Kanj, Souha S., Sfeir, Jad, Yasmine, Mohamad, Abidin, Imran, Martínez, Eduardo Rivera, Nieto, Gabriel Israel Soto, Van Der Meer, Jan T. M., Chambers, Stephen, Murdoch, David R., Holland, David, Morris, Arthur, Raymond, Nigel, Read, Kerry, Dragulescu, Stefan, Ionac, Adina, Mornos, Cristian, Butkevich, O. M., Chipigina, Natalia, Kirill, Ozerecky, Vadim, Kulichenko, Vinogradova, Tatiana, Halim, Magid, Lum, Luh Nah, Tan, Ru San, Lejko Zupanc, Tatjana, Logar, Mateja, Mueller Premru, Manica, Commerford, Patrick, Commerford, Anita, Deetlefs, Eduan, Hansa, Cass, Ntsekhe, Mpiko, Almela, Manuel, Armero, Yolanda, Azqueta, Manuel, Castañeda, Ximena, Cervera, Carlos, Del Rio, Ana, Falces, Carlos, Garcia De La Maria, Cristina, Fita, Guillermina, Gatell, Jose M., Marco, Francesc, Mestres, Carlos A., Miró, José M., Moreno, Asuncion, Ninot, Salvador, Paré, Carlos, Pericas, Joan, Ramirez, Jose, Rovira, Irene, Sitges, Marta, Anguera, Ignasi, Font, Bernat, Guma, Joan Raimon, Bermejo, Javier, Bouza, Emilio, Fernández, Miguel Angel Garcia, Gonzalez Ramallo, Victor, Marín, Mercedes, Muñoz, Patricia, Pedromingo, Miguel, Roda, Jorge, Rodríguez Créixems, Marta, Solis, Jorge, Almirante, Benito, Fernandez Hidalgo, Nuria, Tornos, Pilar, De Alarcón, Arístides, Parra, Ricardo, Alestig, Eric, Johansson, Magnus, Snygg Martin, Ulrika, Pachirat, Orathai, Pachirat, Pimchitra, Pussadhamma, Burabha, Senthong, Vichai, Casey, Anna, Elliott, Tom, Lambert, Peter, Watkin, Richard, Eyton, Christina, Klein, John L., Bradley, Suzanne, Kauffman, Carol, Bedimo, Roger, Corey, G. Ralph, Crowley, Anna Lisa, Douglas, Pamela, Drew, Laura, Fowler, Vance G., Holland, Thomas, Lalani, Tahaniyat, Mudrick, Daniel, Samad, Zaniab, Sexton, Daniel, Stryjewski, Martin, Woods, Christopher W., Lerakis, Stamatios, Cantey, Robert, Steed, Lisa, Wray, Dannah, Dickerman, Stuart A., Bonilla, Hector, Di Persio, Joseph, Salstrom, Sara Jane, Baddley, John, Peterson, Gail, Stancoven, Amy, Afonso, Luis, Kulman, Theresa, Levine, Donald, Rybak, Michael, Cabell, Christopher H., Services de Pneumologie, Exploration Fonctionnelle Respiratoire et Cardiologie (Hôpital Louis Pradel), Hospices Civils de Lyon (HCL), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), International Collaboration on Endocarditis-Prospective Cohort Study (ICE-PCS) Investigators, Université d'Angers (UA)-Université de Rennes 1 (UR1), and Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )

Subjects
Male, MESH: Endocarditis, Time Factors, Medizin, 030204 cardiovascular system & hematology, endocarditis, valve replacement, surgery, Cohort Studies, 0302 clinical medicine, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, 030212 general & internal medicine, Hospital Mortality, MESH: Inpatients, Stroke, MESH: Cohort Studies, MESH: Aged, MESH: Middle Aged, MESH: Cardiac Surgical Procedures, Endocarditis, Mortality rate, Hazard ratio, Middle Aged, stroke, 3. Good health, Cardiac surgery, Infectious Diseases, Infective endocarditis, Female, Cohort study, Adult, Microbiology (medical), medicine.medical_specialty, MESH: Stroke, 03 medical and health sciences, medicine, Humans, MESH: Hospital Mortality, Cardiac Surgical Procedures, Aged, Inpatients, MESH: Humans, Proportional hazards model, business.industry, MESH: Time Factors, MESH: Adult, Odds ratio, medicine.disease, MESH: Male, Surgery, business, MESH: Female
Abstract

International audience; BACKGROUND: The timing of cardiac surgery after stroke in infective endocarditis (IE) remains controversial. We examined the relationship between the timing of surgery after stroke and the incidence of in-hospital and 1-year mortalities. METHODS: Data were obtained from the International Collaboration on Endocarditis-Prospective Cohort Study of 4794 patients with definite IE who were admitted to 64 centers from June 2000 through December 2006. Multivariate logistic regression and Cox regression analyses were performed to estimate the impact of early surgery on hospital and 1-year mortality after adjustments for other significant covariates. RESULTS: Of the 857 patients with IE complicated by ischemic stroke syndromes, 198 who underwent valve replacement surgery poststroke were available for analysis. Overall, 58 (29.3%) patients underwent early surgical treatment vs 140 (70.7%) patients who underwent late surgical treatment. After adjustment for other risk factors, early surgery was not significantly associated with increased in-hospital mortality rates (odds ratio, 2.308; 95% confidence interval [CI], .942-5.652). Overall, probability of death after 1-year follow-up did not differ between 2 treatment groups (27.1% in early surgery and 19.2% in late surgery group, P = .328; adjusted hazard ratio, 1.138; 95% CI, .802-1.650). CONCLUSIONS: There is no apparent survival benefit in delaying surgery when indicated in IE patients after ischemic stroke. Further observational analyses that include detailed pre- and postoperative clinical neurologic findings and advanced imaging data (eg, ischemic stroke size), may allow for more refined recommendations on the optimal timing of valvular surgery in patients with IE and recent stroke syndromes.

Published
2013

23. HACEK Infective Endocarditis: Characteristics and Outcomes from a Large, Multi-National Cohort

Author

Chambers, Stephen T, Murdoch, David, Morris, Arthur, Holland, David, Pappas, Paul, Almela, Manel, Fernández Hidalgo, Nuria, Almirante, Benito, Bouza, Emilio, Forno, Davide, Rio, Ana del, Hannan, Margaret M., Harkness, John, Kanafani, Zeina A., Lalani, Tahaniyat, Lang, Selwyn, Raymond, Nigel, Read, Kerry, Vinogradova, Tatiana, Woods, Christopher W., Wray, Dannah, Corey, G. Ralph, Chu, Vivian H., Clara, Liliana, Sanchez, Marisa, Nacinovich, Francisco, Oses, Pablo Fernandez, Ronderos, Ricardo, Sucari, Adriana, Thierer, Jorge, Casabé, José, Cortes, Claudia, Altclas, Javier, Silvia Kogan, Sanatorio, Spelman, Denis, Athan, Eugene, Harris, Owen, Kennedy, Karina, Tan, Ren, Gordon, David, Papanicolas, Lito, Eisen, Damon, Grigg, Leeanne, Street, Alan, Korman, Tony, Kotsanas, Despina, Dever, Robyn, Jones, Phillip, Konecny, Pam, Lawrence, Richard, Rees, David, Ryan, Suzanne, Feneley, Michael P., Post, Jeffrey, Reinbott, Porl, Gattringer, Rainer, Wiesbauer, Franz, Andrade, Adriana Ribas, de Brito, Ana Cláudia Passos, Guimarães, Armenio Costa, Grinberg, Max, Mansur, Alfredo José, Siciliano, Rinaldo Focaccia, Strabelli, Tania Mara Varejao, Vieira, Marcelo Luiz Campos, de Medeiros Tranchesi, Regina Aparecida, Paiva, Marcelo Goulart, Fortes, Claudio Querido, de Oliveira Ramos, Auristela, Ferraiuoli, Giovanna, Golebiovski, Wilma, Lamas, Cristiane, Santos, Marisa, Weksler, Clara, Karlowsky, James A., Keynan, Yoav, Morris, Andrew M., Rubinstein, Ethan, Jones, Sandra Braun, Garcia, Patricia, Cereceda, M., Fica, Alberto, Mella, Rodrigo Montagna, Barsic, Bruno, Bukovski, Suzana, Krajinovic, Vladimir, Pangercic, Ana, Rudez, Igor, Vincelj, Josip, Freiberger, Tomas, Pol, Jiri, Zaloudikova, Barbora, Ashour, Zainab, Kholy, Amani El, Mishaal, Marwa, Rizk, Hussien, Aissa, Neijla, Alauzet, Corentine, Alla, Francois, Campagnac, Catherine, Doco Lecompte, Thanh, Selton Suty, Christine, Casalta, Jean Paul, Fournier, Pierre Edouard, Habib, Gilbert, Raoult, Didier, Thuny, Franck, Delahaye, Francois, Delahaye, Armelle, Vandenesch, Francois, Donal, Erwan, Donnio, Pierre Yves, Michelet, Christian, Revest, Matthieu, Tattevin, Pierre, Violette, Jérémie, Chevalier, Florent, Jeu, Antoine, Rusinaru, Dan M. D., Sorel, Claire, Tribouilloy, Christophe, Bernard, Yvette, Chirouze, Catherine, Hoen, Bruno, Leroy, Joel, Plesiat, Patrick, Naber, Christoph, Neuerburg, Carl, Mazaheri, Bahram, Athanasia, Sofia, Giannitsioti, Efthymia, Mylona, Elena, Paniara, Olga, Papanicolaou, Konstantinos, Pyros, John, Skoutelis, Athanasios, Sharma, Gautam, Francis, Johnson, Nair, Lathi, Thomas, Vinod, Venugopal, Krishnan, Hannan, Margaret, Hurley, John, Gilon, Dan, Israel, Sarah, Korem, Maya, Strahilevitz, Jacob, Tripodi, Marie Françoise, Casillo, Roberta, Cuccurullo, Susanna, Dialetto, Giovanni, Durante Mangoni, Emanuele, Irene, Mattucci, Ragone, Enrico, Utili, Riccardo, Cecchi, Enrico, De Rosa, Francesco, Imazio, Massimo, Trinchero, Rita, Tebini, Alessandro, Grossi, PAOLO ANTONIO, Lattanzio, Mariangela, Toniolo, Antonio, Goglio, Antonio, Raglio, Annibale, Ravasio, Veronica, Rizzi, Marco, Suter, Fredy, Carosi, Giampiero, Magri, Silvia, Signorini, Liana, Baban, Tania, Kanafani, Zeina, Kanj, Souha S., Sfeir, Jad, Yasmine, Mohamad, Abidin, Imran, Tamin, Syahidah Syed, Martínez, Eduardo Rivera, Nieto, Gabriel Israel Soto, van der Meer, Jan T. M., Chambers, Stephen, Murdoch, David R., Dragulescu, Stefan, Ionac, Adina, Mornos, Cristian, Butkevich, O. M., Chipigina, Natalia, Kirill, Ozerecky, Vadim, Kulichenko, Edathodu, Jameela, Halim, Magid, Lum, Luh Nah, Tan, Ru San, Lejko Zupanc, Tatjana, Logar, Mateja, Mueller Premru, Manica, Commerford, Patrick, Commerford, Anita, Deetlefs, Eduan, Hansa, Cass, Ntsekhe, Mpiko, Almela, Manuel, Armero, Yolanda, Azqueta, Manuel, Castañeda, Ximena, Cervera, Carlos, Falces, Carlos, Garcia de la Maria, Cristina, Fita, Guillermina, Gatell, Jose M., Marco, Francesc, Mestres, Carlos A., Miró, José M., Moreno, Asuncion, Ninot, Salvador, Paré, Carlos, Pericas, Joan, Ramirez, Jose, Rovira, Irene, Sitges, Marta, Anguera, Ignasi, Font, Bernat, Guma, Joan Raimon, Bermejo, Javier, Fernández, Miguel Angel Garcia, Gonzalez Ramallo, Victor, Marín, Mercedes, Muñoz, Patricia, Pedromingo, Miguel, Roda, Jorge, Rodríguez Créixems, Marta, Solis, Jorge, Fernandez Hidalgo, Nuria, Tornos, Pilar, de Alarcón, Arístides, Parra, Ricardo, Alestig, Eric, Johansson, Magnus, Olaison, Lars, Snygg Martin, Ulrika, Pachirat, Orathai, Pachirat, Pimchitra, Pussadhamma, Burabha, Senthong, Vichai, Casey, Anna, Elliott, Tom, Lambert, Peter, Watkin, Richard, Eyton, Christina, Klein, John L., Bradley, Suzanne, Kauffman, Carol, Bedimo, Roger, Crowley, Anna Lisa, Douglas, Pamela, Drew, Laura, Fowler, Vance G., Holland, Thomas, Mudrick, Daniel, Samad, Zaniab, Sexton, Daniel, Stryjewski, Martin, Wang, Andrew, Lerakis, Stamatios, Cantey, Robert, Steed, Lisa, Dickerman, Stuart A., Bonilla, Hector, Dipersio, Joseph, Salstrom, Sara Jane, Baddley, John, Patel, Mukesh, Peterson, Gail, Stancoven, Amy, Afonso, Luis, Kulman, Theresa, Levine, Donald, Rybak, Michael, Cabell, Christopher H., Baloch, Khaula, Dixon, Christy C., Vance G., Fowler J. r., Harding, Tina, Jones Richmond, Marian, Park, Lawrence P., Redick, Thomas, Stafford, Judy, Anstrom, Kevin, Bayer, Arnold S., Karchmer, A. W., Sexton, Daniel J., Cabell, Christopher H, Chu, Vivian, Durack, David T., Eykyn, Susannah, Moreillon, Phillipe, Universitat de Barcelona, University of Otago [Dunedin, Nouvelle-Zélande], Auckland City Hospital, Microbiology Laboratory, Middlemore Hospital, Duke University Medical Center, Clinical and experimental neuroimmunology [IDIBAPS], Institut d'Investigacions Biomèdiques August Pi i Sunyer, Vall d'Hebron University Hospital [Barcelona], Hospital Universitario Gregorio Maranon, Hospital Universitario Gregorio Marañón, Cardiologie, Maria Vittoria Hospital [Turin], Mater Hospitals, University of New South Wales [Sydney] (UNSW), American University of Beirut [Beyrouth] (AUB), Uniformed Services University of the Health Sciences (USUHS), Wellington Hospital Private, Royal North Shore Hospital (RNSH), Russian State Medical University, Durham VA Medical Center, and University of South Carolina [Columbia]

Subjects
Aortic valve, Bacterial Diseases, Genetics and Molecular Biology (all), Valvular Disease, Medizin, Eikenella corrodens, Cardiobacterium, Infection control, Cardiovascular, American-heart-association, Biochemistry, Antimicrobial therapy, Cohort Studies, 0302 clinical medicine, Control d'infeccions, Diagnosis, Odds Ratio, Prevalence, 030212 general & internal medicine, Prospective cohort study, Haemophilus Influenzae, 0303 health sciences, Multidisciplinary, biology, Endocarditis, Medicine (all), Statistics, Congenital Heart Disease, Age Factors, Bacterial, 3. Good health, Management, Stroke, medicine.anatomical_structure, Infectious Diseases, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, Treatment Outcome, Infective endocarditis, Cohort, [SDV.IMM]Life Sciences [q-bio]/Immunology, Medicine, Profile, Health-care professionals, Kingella, Cardiobacterium-hominis, Cohort study, Research Article, medicine.medical_specialty, Drugs and Devices, Science, Haemophilus, Referral bias, Statistics, Nonparametric, Medical Devices, 03 medical and health sciences, Internal medicine, Kingella Kingae Infection, medicine, Humans, Nonparametric, Aggregatibacter, Endocarditis, Bacterial, Biochemistry, Genetics and Molecular Biology (all), Agricultural and Biological Sciences (all), Staphylococcus-aureus, Heart Failure, 030306 microbiology, business.industry, Acute Cardiovascular Problems, Bloodstream Infections, medicine.disease, biology.organism_classification, Surgery, Valve endocarditis, Cardiobacterium hominis, business
Abstract

International audience; The HACEK organisms (Haemophilus species, Aggregatibacter species, Cardiobacterium hominis, Eikenella corrodens, and Kingella species) are rare causes of infective endocarditis (IE). The objective of this study is to describe the clinical characteristics and outcomes of patients with HACEK endocarditis (HE) in a large multi-national cohort. Patients hospitalized with definite or possible infective endocarditis by the International Collaboration on Endocarditis Prospective Cohort Study in 64 hospitals from 28 countries were included and characteristics of HE patients compared with IE due to other pathogens. Of 5591 patients enrolled, 77 (1.4%) had HE. HE was associated with a younger age (47 vs. 61 years; p < 0.001), a higher prevalence of immunologic/vascular manifestations (32% vs. 20%; p < 0.008) and stroke (25% vs. 17% p = 0.05) but a lower prevalence of congestive heart failure (15% vs. 30%; p = 0.004), death in-hospital (4% vs. 18%; p = 0.001) or after 1 year follow-up (6% vs. 20%; p = 0.01) than IE due to other pathogens (n = 5514). On multivariable analysis, stroke was associated with mitral valve vegetations (OR 3.60; CI 1.34-9.65; p < 0.01) and younger age (OR 0.62; CI 0.49-0.90; p < 0.01). The overall outcome of HE was excellent with the in-hospital mortality (4%) significantly better than for non-HE (18%; p < 0.001). Prosthetic valve endocarditis was more common in HE (35%) than non-HE (24%). The outcome of prosthetic valve and native valve HE was excellent whether treated medically or with surgery. Current treatment is very successful for the management of both native valve prosthetic valve HE but further studies are needed to determine why HE has a predilection for younger people and to cause stroke. The small number of patients and observational design limit inferences on treatment strategies. Self selection of study sites limits epidemiological inferences.

Published
2013

32. Platelet count does not predict bleeding in cirrhotic patients: Results from the PRO-LIVER Study

Author

Basili, S. a, Raparelli, V. b., Napoleone, L. b., Talerico, G. a., Corazza, G. R. c., Perticone, F. d., Sacerdoti, D. e., Andriulli, A. f., Licata, A. g., Pietrangelo, A., Picardi, A. i., Raimondo, G. j., Violi, F., Palasciano, G., D’Alitto, F., Palmieri, V. O., Santovito, D., Michele, Di, Croce, D., Brocco, G., Fasolato, S., Cecchetto, S., Bombonato, L., Bertoni, G., Restuccia, M., Andreozzi, T., Liguori, P., Caroleo, M. L., Perticone, B., Staltari, M., Manfredini, O., Giorgi, De, Averna, A., Giammanco, M., Granito, A., Pettinari, A., Marinelli, I., Bolondi, S., Falsetti, L., Salvi, L., Durante-Mangoni, A., Cesaro, E., Farinaro, F., Ragone, V., Morana, E., Ippolito, I., Iacobellis, A., Niro, A., Merla, G., Maimone, A., Cacciola, S., Varvara, I., Drenaggi, D., Staffolani, D., Vespasiani-Gentilucci, S., Galati, U., Gallo, G., Davì, P., Schiavone, G., Santilli, C., Tana, F., Soresi, C., Bianchi, Giovanni, Carderi, B., Pinto, I., Tuttolomondo, A., Ferrari, A., Gresele, G., Fierro, P., Morelli, T., Laffi, O., Romanelli, G., Arena, R. G., Stasi, U., Gasbarrini, A., Garcovich, M., Zocco, M. A., Riccardi, L., Ainora, M. E., Capeci, W., Martino, Giuseppe, Nobili, P., Cavallo, L., Frugiuele, M., Greco, P., Ventura, P., Cuoghi, C., Marcacci, M., Serviddio, G., Vendemiale, G., Villani, R., Gargano, R., Vidili, G., Cesare, Di, Masala, V., Delitala, M., Invernizzi, G., Vincenzo, P., Minno, Di, Tufano, G., Purrello, A., Privitera, F., Forgione, G., Curigliano, A., Senzolo, V., Rodríguez-Castro, M., Giannelli, K. I., Serra, G., Neri, C., Pignataro, S., Rizzetto, P., Debernardi, M., Svegliati, V. W., Bergamaschi, B. G., Masotti, G., Costanzo, M., Antonio, F., Angelico, F., Del, Ben, Polimeni, M., Proietti, L., Cangemi, M., Romiti, R., Toriello, G. F., Sperduti, F., Santangelo, N., Visioli, G., Todisco, G., Vestri, Anna, Farcomeni, R., Corrao, A., Gobbi, S., Corradini, E., Costantino, G., Tripepi, G., Angelico, M., Bolondi, L., D’Amico, G., Franchis, De, Gatta, R., Tassone, A., Anzaldi, E. J., Barone, M., Bazzini, M., Bianchi, C., Boari, P. I., Bracco, B., Buonauro, C., Buttà, A., Buzzetti, E., Calabria, S., Caradio, F., Carleo, P., Carrabba, Maria, Castorani, D., Cecchetto, L., Cicco, L., Cimini, S., Colombo, C., B. M., Vuono, De, Denegri, S., Del, Corso, Giosia, Di, Donnarumma, P., Giorgini, E., Grassi, P., Grembiale, D., Hijazi, A., Iamele, D., Lorusso, L., Marchese, G., Marra, Alberto, Masala, M., Miceli, M., Montebianco, G., Murgia, A. L., Naccarato, G., Padula, P., Pattoneri, D., Perego, P., Pesce, F., Petramala, P., Piano, L., Pinto, S., Pinna, D., Pignataro, M., Pretti, F. S., Pucci, V., Salinaro, G., Salzano, F., Santarossa, A., Scarpini, C., Scicali, F., Sirico, R., Suppressa, D., Talia, P., Torres, M., Traversa, D., Vazzana, M., Vecchio, Claudia, Vettore, R., Vitale, E., Basili, S., Raparelli, V., Napoleone, L., Talerico, G., Corazza, G.R., Perticone, F., Sacerdoti, D., Andriulli, A., Licata, A., Pietrangelo, A., Picardi, A., Raimondo, G., Violi, F., Palasciano, Giuseppe, D’Alitto, Felicia, Palmieri, Vincenzo Ostilio, Santovito, Daniela, Di Michele, Dario, Croce, Giuseppe, Brocco, Silvia, Fasolato, Silvano, Cecchetto, Lara, Bombonato, Giancarlo, Bertoni, Michele, Restuccia, Tea, Andreozzi, Paola, Liguori, Maria Livia, Caroleo, Benedetto, Perticone, Maria, Staltari, Orietta, Manfredini, Roberto, De Giorgi, Alfredo, Averna, Maurizio, Giammanco, Antonina, Granito, Alessandro, Pettinari, Irene, Marinelli, Sara, Bolondi, Luigi, Falsetti, Lorenzo, Salvi, Aldo, Durante-Mangoni, Emanuele, Cesaro, Flavio, Farinaro, Vincenza, Ragone, Enrico, Morana, Ignazio, Ippolito, Antonio, Iacobellis, Angelo, Niro, Grazia, Merla, Antonio, Maimone, Sergio, Cacciola, Irene, Varvara, Doriana, Drenaggi, Davide, Staffolani, Silvia, Vespasiani-Gentilucci, Umberto, Galati, Giovanni, Gallo, Paolo, Davì, Giovanni, Schiavone, Cosima, Santilli, Francesca, Tana, Claudio, Soresi, Maurizio, Bianchi Giovanni, Battista, Carderi, Isabella, Pinto, Antonio, Tuttolomondo, Antonino, Ferrari, Giovanni, Gresele, Paolo, Fierro, Tiziana, Morelli, Olivia, Laffi, Giacomo, Romanelli, Roberto Giulio, Arena, Umberto, Stasi, Cristina, Gasbarrini, Antonio, Garcovich, Matteo, Zocco, Maria Assunta, Riccardi, Laura, Ainora, Maria Elena, Capeci, William, Martino Giuseppe, Pio, Nobili, Lorenzo, Cavallo, Maurizio, Frugiuele, Pierluigi, Greco, Antonio, Ventura, Paolo, Cuoghi, Chiara, Marcacci, Matteo, Serviddio, Gaetano, Vendemiale, Gianluigi, Villani, Rosanna, Gargano, Ruggiero, Vidili, Gianpaolo, Di Cesare, Valentina, Masala, Maristella, Delitala, Giuseppe, Invernizzi, Pietro, Vincenzo, Ronca, Di Minno, Giovanni, Tufano, Antonella, Purrello, Francesco, Privitera, Graziella, Forgione, Alessandra, Curigliano, Valentina, Senzolo, Marco, Rodríguez-Castro, Kryssia Isabel, Giannelli, Gianluigi, Serra, Carla, Neri, Sergio, Pignataro, Pietro, Rizzetto, Mario, Debernardi, Venon Wilma, Svegliati, Baroni Gianluca, Bergamaschi, Gaetano, Masotti, Michela, Costanzo, Filippo, Antonio, Figliomeni, Angelico, Francesco, Del Ben, Maria, Polimeni, Licia, Proietti, Marco, Cangemi, Roberto, Romiti Giulio, Francesco, Toriello, Filippo, Sperduti, Nicolò, Santangelo, Giuseppe, Visioli, Giacomo, Todisco, Tommaso, Vestri Anna, Rita, Farcomeni, Alessio, Corrao, Salvatore, Gobbi, Paolo, Corradini, Elena, Costantino, Giorgio, Tripepi, Giovanni, Angelico, Mario, D’Amico, Gennaro, De Franchis, Roberto, Gatta, Angelo, Tassone, Eliezer Joseph, Anzaldi, Massimiliano, Barone, Milena, Bazzini, Cristina, Bianchi, Paola Ilaria, Boari, Benedetta, Bracco, Christian, Buonauro, Agostino, Buttà, Carmelo, Buzzetti, Elena, Calabria, Stefano, Caradio, Federica, Carleo, Pietro, Carrabba Maria, Domenica, Castorani, Luigi, Cicco, Sebastiano, Cimini, Claudia, Colombo, Barbara Maria, De Vuono, Stefano, Denegri, Andrea, Del Corso, Lisette, Di Giosia, Paolo, Donnarumma, Emilia, Giorgini, Paolo, Grassi, Davide, Grembiale, Alessandro, Hijazi, Daniel, Iamele, Luigi, Lorusso, Giusi, Marchese, Alessandra, Marra Alberto, Maria, Miceli, Giuseppe, Montebianco, Abenavoli Ludovico, Murgia, Giuseppe, Naccarato, Paola, Padula, Donatella, Pattoneri, Paolo, Perego, Francesca, Pesce, Paola, Petramala, Luigi, Piano, Salvatore, Pinto, Daniela, Pinna, Miriam, Pignataro, Francesca Serena, Pretti, Vincenzo, Pucci, Giacomo, Salinaro, Francesco, Salzano, Andrea, Santarossa, Claudia, Scarpini, Francesca, Scicali, Roberto, Sirico, Domenico, Suppressa, Patrizia, Talia, Michela, Torres, Daniele, Traversa, Matteo, Vazzana, Natale, Vecchio Claudia, Rita, Vettore, Elia, Vitale, Francesco, Basili, S, Raparelli, V, Napoleone, L, Talerico, G, Corazza, G, Perticone, F, Sacerdoti, D, Andriulli, A, Licata, A, Pietrangelo, A, Picardi, A, Raimondo, G, Violi, F, Palasciano, G, D'Alitto, F, Palmieri, V, Santovito, D, Di Michele, D, Croce, G, Brocco, S, Fasolato, S, Cecchetto, L, Bombonato, G, Bertoni, M, Restuccia, T, Andreozzi, P, Liguori, M, Caroleo, B, Perticone, M, Staltari, O, Manfredini, R, De Giorgi, A, Averna, M, Giammanco, A, Granito, A, Pettinari, I, Marinelli, S, Bolondi, L, Falsetti, L, Salvi, A, Durante-Mangoni, E, Cesaro, F, Farinaro, V, Ragone, E, Morana, I, Ippolito, A, Iacobellis, A, Niro, G, Merla, A, Maimone, S, Cacciola, I, Varvara, D, Drenaggi, D, Staffolani, S, Vespasiani-Gentilucci, U, Galati, G, Gallo, P, Davi, G, Schiavone, C, Santilli, F, Tana, C, Soresi, M, Bianchi Giovanni, B, Carderi, I, Pinto, A, Tuttolomondo, A, Ferrari, G, Gresele, P, Fierro, T, Morelli, O, Laffi, G, Romanelli, R, Arena, U, Stasi, C, Gasbarrini, A, Garcovich, M, Zocco, M, Riccardi, L, Ainora, M, Capeci, W, Martino Giuseppe, P, Nobili, L, Cavallo, M, Frugiuele, P, Greco, A, Ventura, P, Cuoghi, C, Marcacci, M, Serviddio, G, Vendemiale, G, Villani, R, Gargano, R, Vidili, G, Di Cesare, V, Masala, M, Delitala, G, Invernizzi, P, Vincenzo, R, Di Minno, G, Tufano, A, Purrello, F, Privitera, G, Forgione, A, Curigliano, V, Senzolo, M, Rodriguez-Castro, K, Giannelli, G, Serra, C, Neri, S, Pignataro, P, Rizzetto, M, Debernardi, V, Svegliati, B, Bergamaschi, G, Masotti, M, Costanzo, F, Antonio, F, Angelico, F, Del Ben, M, Polimeni, L, Proietti, M, Cangemi, R, Romiti, G, Toriello, F, Sperduti, N, Santangelo, G, Visioli, G, Todisco, T, Vestri Anna, R, Farcomeni, A, Corrao, S, Gobbi, P, Corradini, E, Costantino, G, Tripepi, G, Angelico, M, D'Amico, G, De Franchis, R, Gatta, A, Tassone, E, Anzaldi, M, Barone, M, Bazzini, C, Bianchi, P, Boari, B, Bracco, C, Buonauro, A, Butta, C, Buzzetti, E, Calabria, S, Caradio, F, Carleo, P, Carrabba Maria, D, Castorani, L, Cicco, S, Cimini, C, Colombo, B, De Vuono, S, Denegri, A, Del Corso, L, Di Giosia, P, Donnarumma, E, Giorgini, P, Grassi, D, Grembiale, A, Hijazi, D, Iamele, L, Lorusso, G, Marchese, A, Marra, A, Miceli, G, Montebianco, A, Murgia, G, Naccarato, P, Padula, D, Pattoneri, P, Perego, F, Pesce, P, Petramala, L, Piano, S, Pinto, D, Pinna, M, Pignataro, F, Pretti, V, Pucci, G, Salinaro, F, Salzano, A, Santarossa, C, Scarpini, F, Scicali, R, Sirico, D, Suppressa, P, Talia, M, Torres, D, Traversa, M, Vazzana, N, Vecchio Claudia, R, Vettore, E, Vitale, F, S Basili, V Raparelli, L Napoleone, G Talerico, G Corazza, F Perticone, D Sacerdoti, A Andriulli, A Licata, A Pietrangelo, A Picardi, G Raimondo, F Violi, MD on behalf of PRO-LIVER Collaborator, Palasciano Giuseppe, D’Alitto Felicia, Palmieri Vincenzo Ostilio, Santovito Daniela, Di Michele Dario, Croce Giuseppe, Brocco Silvia, Fasolato Silvano, Cecchetto Lara, Bombonato Giancarlo, Bertoni Michele, Restuccia Tea, Andreozzi Paola, Liguori Maria Livia, Caroleo Benedetto, Perticone Maria, Staltari Orietta, Manfredini Roberto, De Giorgi Alfredo, Averna Maurizio, Giammanco Antonina, Granito Alessandro, Pettinari Irene, Marinelli Sara, Bolondi Luigi, Falsetti Lorenzo, Salvi Aldo, Durante-Mangoni Emanuele, Cesaro Flavio, Farinaro Vincenza, Ragone Enrico, Morana Ignazio, Ippolito Antonio, Iacobellis Angelo, Niro Grazia, Merla Antonio, Maimone Sergio, Cacciola Irene, Varvara Doriana, Drenaggi Davide, Staffolani Silvia, Vespasiani-Gentilucci Umberto, Galati Giovanni, Gallo Paolo, Davi Giovanni, Schiavone Cosima, Santilli Francesca, Tana Claudio, Soresi Maurizio, Bianchi Giovanni Battista, Carderi Isabella, Pinto Antonio, Tuttolomondo Antonino, Ferrari Giovanni, Gresele Paolo, Fierro Tiziana, Morelli Olivia, Laffi Giacomo, Romanelli Roberto Giulio, Arena Umberto, Stasi Cristina, Gasbarrini Antonio, Garcovich Matteo, Zocco Maria Assunta, Riccardi Laura, Ainora Maria Elena, Capeci William, Martino Giuseppe Pio, Nobili Lorenzo, Cavallo Maurizio, Frugiuele Pierluigi, Greco Antonio, Ventura Paolo, Cuoghi Chiara, Marcacci Matteo, Serviddio Gaetano, Vendemiale Gianluigi, Villani Rosanna, Gargano Ruggiero, Vidili Gianpaolo, Di Cesare Valentina, Masala Maristella, Delitala Giuseppe, Invernizzi Pietro, Vincenzo Ronca, Di Minno Giovanni, Tufano Antonella, Purrello Francesco, Privitera Graziella, Forgione Alessandra, Curigliano Valentina, Senzolo Marco, Rodríguez-Castro Kryssia Isabel, Giannelli Gianluigi, Serra Carla, Neri Sergio, Pignataro Pietro, Rizzetto Mario, Debernardi Venon Wilma, Svegliati Baroni Gianluca, Bergamaschi Gaetano, Masotti Michela, Costanzo Filippo, Antonio Figliomeni, Angelico Francesco, Del Ben Maria, Polimeni Licia, Proietti Marco, Cangemi Roberto, Romiti Giulio Francesco, Toriello Filippo, Sperduti Nicolò, Santangelo Giuseppe, Visioli Giacomo, Todisco Tommaso, Vestri Anna Rita, Farcomeni Alessio, Corrao Salvatore, Gobbi Paolo, Corradini Elena, Costantino Giorgio, Tripepi Giovanni, Angelico Mario, D’Amico Gennaro, de Franchis Roberto, Gatta Angelo, Tassone Eliezer Joseph, Anzaldi Massimiliano, Barone Milena, Bazzini Cristina, Bianchi Paola Ilaria, Boari Benedetta, Bracco Christian, Buonauro Agostino, Buttà Carmelo, Buzzetti Elena, Calabria Stefano, Caradio Federica, Carleo Pietro, Carrabba Maria Domenica, Castorani Luigi, Cicco Sebastiano, Cimini Claudia, Colombo Barbara Maria, De Vuono Stefano, Denegri Andrea, Del Corso Lisette, Di Giosia Paolo, Donnarumma Emilia, Giorgini Paolo, Grassi Davide, Grembiale Alessandro, Hijazi Daniel, Iamele Luigi, Lorusso Giusi, Marchese Alessandra, Marra Alberto Maria, Miceli Giuseppe, Montebianco Abenavoli Ludovico, Murgia Giuseppe, Naccarato Paola, Padula Donatella, Pattoneri Paolo, Perego Francesca, Pesce Paola, Petramala Luigi, Piano Salvatore, Pinto Daniela, Pinna Miriam, Pignataro Francesca Serena, Pretti Vincenzo, Pucci Giacomo, Salinaro Francesco, Salzano Andrea, Santarossa Claudia, Scarpini Francesca, Scicali Roberto, Sirico Domenico, Suppressa Patrizia, Talia Michela, Torres Daniele, Traversa Matteo, Vazzana Natale, Vecchio Claudia Rita, Vettore Elia, Vitale Francesco, Corazza, G. R., Guidacci, Raimondo, Palasciano, G., D'Alitto, F., Palmieri, V. O., Santovito, D., Di Michele, D., Croce, G., Brocco, S., Fasolato, S., Cecchetto, L., Bombonato, G., Bertoni, M., Restuccia, T., Andreozzi, P., Liguori, M. L., Caroleo, B., Perticone, M., Staltari, O., Manfredini, R., De Giorgi, A., Averna, M., Giammanco, A., Granito, A., Pettinari, I., Marinelli, S., Bolondi, L., Falsetti, L., Salvi, A., Durante-Mangoni, E., Cesaro, F., Farinaro, V., Ragone, E., Morana, I., Ippolito, A., Iacobellis, A., Niro, G., Merla, A., Maimone, S., Cacciola, I., Varvara, D., Drenaggi, D., Staffolani, S., Vespasiani-Gentilucci, U., Galati, G., Gallo, P., Davi, G., Schiavone, C., Santilli, F., Tana, C., Soresi, M., Bianchi Giovanni, B., Carderi, I., Pinto, A., Tuttolomondo, A., Ferrari, G., Gresele, P., Fierro, T., Morelli, O., Laffi, G., Romanelli, R. G., Arena, U., Stasi, C., Gasbarrini, A., Garcovich, M., Zocco, M. A., Riccardi, L., Ainora, M. E., Capeci, W., Martino Giuseppe, P., Nobili, L., Cavallo, M., Frugiuele, P., Greco, A., Ventura, P., Cuoghi, C., Marcacci, M., Serviddio, G., Vendemiale, G., Villani, R., Gargano, R., Vidili, G., Di Cesare, V., Masala, M., Delitala, G., Invernizzi, P., Vincenzo, R., Di Minno, G., Tufano, A., Purrello, F., Privitera, G., Forgione, A., Curigliano, V., Senzolo, M., Rodriguez-Castro, K. I., Giannelli, G., Serra, C., Neri, S., Pignataro, P., Rizzetto, M., Debernardi, V. W., Svegliati, B. G., Bergamaschi, G., Masotti, M., Costanzo, F., Antonio, F., Angelico, F., Del Ben, M., Polimeni, L., Proietti, M., Cangemi, R., Romiti, G. F., Toriello, F., Sperduti, N., Santangelo, G., Visioli, G., Todisco, T., Vestri Anna, R., Farcomeni, A., Corrao, S., Gobbi, P., Corradini, E., Costantino, G., Tripepi, G., Angelico, M., D'Amico, G., De Franchis, R., Gatta, A., Tassone, E. J., Anzaldi, M., Barone, M., Bazzini, C., Bianchi, P. I., Boari, B., Bracco, C., Buonauro, A., Butta, C., Buzzetti, E., Calabria, S., Caradio, F., Carleo, P., Carrabba Maria, D., Castorani, L., Cicco, S., Cimini, C., Colombo, B. M., De Vuono, S., Denegri, A., Del Corso, L., Di Giosia, P., Donnarumma, E., Giorgini, P., Grassi, D., Grembiale, A., Hijazi, D., Iamele, L., Lorusso, G., Marchese, A., Marra, A. M., Miceli, G., Montebianco, A. L., Murgia, G., Naccarato, P., Padula, D., Pattoneri, P., Perego, F., Pesce, P., Petramala, L., Piano, S., Pinto, D., Pinna, M., Pignataro, F. S., Pretti, V., Pucci, G., Salinaro, F., Salzano, A., Santarossa, C., Scarpini, F., Scicali, R., Sirico, D., Suppressa, P., Talia, M., Torres, D., Traversa, M., Vazzana, N., Vecchio Claudia, R., Vettore, E., and Vitale, F.

Subjects
Liver Cirrhosis, Male, Settore MED/09 - Medicina Interna, 030204 cardiovascular system & hematology, Gastroenterology, Severity of Illness Index, cjirrhosis, ACTIVATION, 0302 clinical medicine, Risk Factors, Medicine, Platelet, Prospective Studies, Prospective cohort study, RISK, Aged, 80 and over, medicine.diagnostic_test, PRO-LIVER, Platelet, cirrhosis, gastrointestinal bleeding, ASSOCIATION, Middle Aged, Prognosis, Italy, 030211 gastroenterology & hepatology, Female, Gastrointestinal Hemorrhage, Human, Adult, Platelets, medicine.medical_specialty, Prognosi, Liver Cirrhosi, MEDLINE, COAGULATION, gastrointestinal bleeding, Socio-culturale, Hemorrhage, Hepatology, Follow-Up Studie, 03 medical and health sciences, Text mining, Internal medicine, Severity of illness, ENDOTOXEMIA, Pro-Liver Study, Humans, HEMOSTASIS, International Normalized Ratio, Aged, Proportional Hazards Models, Prothrombin time, Cirrhosi, Platelet Count, Bleeding, Liver Cirrhosis, business.industry, Proportional hazards model, Platelet Count, Risk Factor, cirrhosis, bleeding, Thrombocytopenia, Prospective Studie, THROMBOSIS, Platelets, cjirrhosis, bleeding, PRO-LIVER, Proportional Hazards Model, Prothrombin Time, business, DECOMPENSATED CIRRHOSIS, Follow-Up Studies
Abstract

OBJECTIVES: Thrombocytopenia is a hallmark for patients with cirrhosis and it is perceived as a risk factor for bleeding events. However, the relationship between platelet count and bleeding is still unclear. METHODS: We investigated the relationship between platelet count and major or clinical relevant nonmajor bleedings during a follow-up of ∼4 years. RESULTS: A total of 280 cirrhotic patients with different degrees of liver disease (67% males; age 64±37 years; 47% Child–Pugh B and C) were followed up for a median of 1,129 (interquartile range: 800–1,498) days yielding 953.12 patient-year of observation. The annual rate of any significant bleeding was 5.45%/year (3.57%/year and 1.89%/year for major and minor bleeding, respectively). Fifty-two (18.6%) patients experienced a major (n=34) or minor (n=18) bleeding event, predominantly from gastrointestinal origin. Platelet counts progressively decreased with the worsening of liver disease and were similar in patients with or without major or minor bleeding: a platelet count ≤50×103/μl was detected in 3 (6%) patients with and in 20 (9%) patients without any bleeding event. Conversely, prothrombin time-international normalized ratio was slightly higher in patients with overall or major bleeding. On Cox proportional hazard analysis, only a previous gastrointestinal bleeding (hazard ratio (HR): 1.96; 95% confidence interval: 1.11–3.47; P=0.020) and encephalopathy (HR: 2.05; 95% confidence interval: 1.16–3.62; P=0.013) independently predicted overall bleeding events. CONCLUSIONS: Platelet count does not predict unprovoked major or minor bleeding in cirrhotic patients.

Published
2018

33. Anthropometric parameters and liver histology influence lipid metabolic changes in HCV chronic hepatitis on direct-acting antiviral treatment

Author

Emanuele Durante-Mangoni, Martina Vitrone, Enrico Ragone, Erasmo Falco, Domenico Iossa, Massimo Gagliardi, Rosa Zampino, Iossa, Domenico, Vitrone, Martina, Gagliardi, Massimo, Falco, Erasmo, Ragone, Enrico, Zampino, Rosa, and Durante-Mangoni, Emanuele

Subjects
medicine.medical_specialty, Apolipoprotein B, Hepatitis C virus, medicine.disease_cause, Gastroenterology, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Fibrosis, lipid, Internal medicine, Medicine, Body mass index (BMI), direct-acting antiviral treatment (DAA treatment), biology, Triglyceride, business.industry, Cholesterol, Fatty liver, Lipid metabolism, General Medicine, medicine.disease, waist circumference, chemistry, 030220 oncology & carcinogenesis, biology.protein, 030211 gastroenterology & hepatology, lipids (amino acids, peptides, and proteins), Original Article, Steatosis, business, hepatitis C virus (HCV)
Abstract

Background: Hepatitis C virus (HCV) infection affects lipid metabolism. We investigated the impact of direct-acting antiviral (DAA) treatment on lipid metabolism in chronic hepatitis C (CHC), with a focus on the effects of anthropometric parameters and liver histology. We also analyzed the dynamics of metabolic indexes used to estimate cardiovascular risk.Methods: In 49 patients with CHC treated with DAAs, lipid metabolic changes, anthropometric parameters, liver histology and cardiovascular risk indexes, including triglyceride to HDL ratio (Tr/HDL), fatty liver index (FLI) and visceral adiposity index (VAI) were evaluated at baseline (BL), end of treatment (EOT) and 12 [sustained virological response (SVR) 12] and 24 (SVR24) weeks after EOT.Results: SVR occurred in 96% of cases. Total and LDL cholesterol and ApoB levels increased significantly between BL and EOT (P

Published
2021

34. Hepatitis B virus reactivation after heart transplant: Incidence and clinical impact

Author

Martina Vitrone, Emanuele Durante-Mangoni, Ciro Maiello, Domenico Iossa, Luca Rinaldi, Roberto Andini, Rosa Molaro, Pia Clara Pafundi, Rosa Zampino, Antonio Parrella, Enrico Ragone, Vitrone, Martina, Iossa, Domenico, Rinaldi, Luca, Pafundi, Pia Clara, Molaro, Rosa, Parrella, Antonio, Andini, Roberto, Ragone, Enrico, Maiello, Ciro, Zampino, Rosa, and Durante-Mangoni, Emanuele

Subjects
Adult, Male, medicine.medical_specialty, HBsAg, Occult hepatitis B infection (OBI), medicine.medical_treatment, Hepatitis B reactivation, 030230 surgery, medicine.disease_cause, Polymerase Chain Reaction, Gastroenterology, Cohort Studies, Immunocompromised Host, 03 medical and health sciences, Liver disease, 0302 clinical medicine, Virology, Internal medicine, Genotype, medicine, Humans, Aged, Hepatitis B virus, business.industry, Virological event, Incidence, Incidence (epidemiology), Mortality rate, virus diseases, Immunosuppression, Middle Aged, Hepatitis B, medicine.disease, digestive system diseases, Infectious Diseases, Liver, Heart failure, Immunology, Heart Transplantation, Heart transplant, Female, Virus Activation, 030211 gastroenterology & hepatology, business, Immunosuppressive Agents, Follow-Up Studies
Abstract

Background Occult hepatitis B infection consists of persistence of HBV genomes in hepatocytes,absence of serum HBsAg, low/undetectable serum HBVDNA. Reactivation of HBV infection may occur during immunosuppression, but few data are available in heart transplant. Objectives We followed-up heart recipients with or without markers of previous HBV infection,evaluating prevalence of HBV markers, incidence of HBV reactivation and its virological and clinical features. Study design Heart failure patients listed for heart transplant (2007–2013) were screened for current or past HBV infection. Transplanted patients with past HBV infection (anti-HBc+/±anti-HBs+/HBVDNA−) were followed up as cases, and an equal number of HBV negative patients as controls. Virological reactivation was detected by standard real-time and home-made highly sensitive PCR (surface/core HBVDNA regions). Clinical status and progression were assessed by liver histology, ultrasound or elastography. Results 67 patients underwent heart transplant, including 4 (5.9%) HBsAg+ subjects. Cases were 11/67 (16.4%). During a median follow-up of 30 months, only one of these 11 patients presented viral reactivation (HBVDNA 209 IU/mL) at month 22, and started antiviral treatment. Four other recipients showed virological events of uncertain significance (sensitive PCR-only intermittently positive). Clinical signs of liver disease were observed in only one case at the last follow-up. A nonsignificant difference in survival was observed between cases and all other heart recipients without prior HBV contact (death rate 5/11 vs 15/52, respectively; p = 0.097). Conclusions HBV genotypic reactivation in HBsAg−/anti-HBc+/HBVDNA− heart recipients is uncommon. Virological events of uncertain significance occur more frequently; their clinical impact seems to be negligible.

Published
2017

35. Incidence and Recurrence of Portal Vein Thrombosis in Cirrhotic Patients

Author

Violi, F., Corazza, G. R., Caldwell, S. H., Talerico, G., Romiti, G. F., Napoleone, L., Perticone, F., Bolondi, L., Pietrangelo, A., Vestri, A. R., Raparelli, V., Basili, S., Elena, A. M., Paola, A., Angelo, A., Bottino, Francesco, Mario, A., Antonio, F., Massimiliano, A., Umberto, A., Maurizio, A., Milena, B., Cristina, B., Gaetano, B., Michele, B., Battista, B. G., Ilaria, B. P., Benedetta, B., Giancarlo, B., Christian, B., Silvia, B., Agostino, B., Carmelo, B., Buzzetti, E., Irene, C., Stefano, C., Roberto, C., William, C., Santagati, Federica, Isabella, C., Pietro, C., Benedetto, C., Domenica, C. M., Luigi, C., Maurizio, C., Lara, C., Flavio, C., Sebastiano, C., Claudia, C., Maria, C. B., Elena, C., Amato, Salvatore, Giorgio, C., Filippo, C., Giuseppe, C., Chiara, C., Valentina, C., Felicia, D., Gennaro, D., Roberto, D. F., Alfredo, D. G., Stefano, D. V., Wilma, D. V., Maria, D. B., Lisette, D. C., Giuseppe, D., Andrea, D., Valentina, D. C., Paolo, D. G., Dario, D. M., Giovanni, D. M., Emilia, D., Davide, D., Emanuele, D. -M., Falsetti, L., Alessio, F., Vincenza, F., Silvano, F., Giovanni, F., Tiziana, F., Alessandra, F., Pierluigi, F., Giovanni, G., Vigneri, Paolo, Matteo, G., Ruggiero, G., Antonio, G., Angelo, G., Antonina, G., Gianluigi, G., Alessandro, G., Davide, G., Daniel, H., Angelo, I., Luigi, I., Pietro, I., Antonio, I., Giacomo, L., Anna, L., Livia, L. M., Giusi, L., Sergio, M., Roberto, M., Matteo, M., Alessandra, M., Sara, M., Maria, M. A., Pio, M. G., Maristella, M., Michela, M., Antonio, M., Giuseppe, M., Ludovico, M. A., Ignazio, M., Olivia, M., Paola, N., Sergio, N., Grazia, N., Lorenzo, N., Donatella, P., Giuseppe, P., Ostilio, P. V., Daniele, P., Francesca, P., Maria, P., Paola, P., Luigi, P., Irene, P., Salvatore, P., Antonio, P., Serena, P. F., Pietro, P., Pasquale, P., Miriam, P., Daniela, P., Licia, P., Vincenzo, P., Graziella, P., Giacomo, P., Francesco, P., Enrico, R., Giovanni, R., Tea, R., Laura, R., Mario, R., Isabel, R. -C. K., Giulio, R. R., Eleonora, R., David, S., Francesco, S., Aldo, S., Andrea, S., Giuseppe, S., Claudia, S., Francesca, S., Daniela, S., Cosima, S., Roberto, S., Marco, S., Carla, S., Gaetano, S., Domenico, S., Maurizio, S., Nicolo, S., Silvia, S., Orietta, S., Stasi, C., Patrizia, S., Gianluca, S. B., Michela, T., Claudio, T., Joseph, T. E., Tommaso, T., Filippo, T., Daniele, T., Matteo, T., Giovanni, T., Antonella, T., Antonino, T., Doriana, V., Natale, V., Rita, V. C., Gianluigi, V., Paolo, V., Umberto, V. -G., Elia, V., Gianpaolo, V., Villani, R., Ronca, V., Giacomo, V., Francesco, V., Assunta, Z. M., Paolo, P., Marco, P., and Francesco Violi, Gino Roberto Corazza, Stephen H. Caldwell, Giovanni Talerico, Giulio Francesco Romiti, Laura Napoleone, Francesco Perticone, Luigi Bolondi, Antonello Pietrangelo, Anna Rita Vestri, Valeria Raparelli, Stefania Basili, Ainora Maria Elena, Andreozzi Paola, AndriulliAngelo,Angelico Francesco, Angelico Mario, Figliomeni Antonio, Anzaldi Massimiliano, Arena Umberto, Averna Maurizio, Barone Milena, Bazzini Cristina, Bergamaschi Gaetano, Bertoni Michele, Bianchi, Giovanni Battista, Bianchi Paola Ilaria, Boari Benedetta, Bombonato Giancarlo, Bracco Christian, Brocco Silvia, Buonauro, Agostino, Buttà Carmelo, Buzzetti Elena, Cacciola Irene, Calabria Stefano, Cangemi Roberto, Capeci William, Caradio, Federica, Carderi Isabella, Carleo Pietro, Caroleo Benedetto, Carrabba Maria Domenica, Castorani Luigi, Cavallo Maurizio, Cecchetto Lara, Cesaro Flavio, Cicco Sebastiano, Cimini Claudia, Colombo Barbara Maria, Corradini Elena, Corrao Salvatore, Costantino Giorgio, Costanzo Filippo, Croce Giuseppe, Cuoghi Chiara, Curigliano Valentina, D’Alitto Felicia, D’Amico Gennaro, De Franchis Roberto, De Giorgi Alfredo, De Vuono Stefano, Debernardi Venon Wilma, Del Ben Maria, Del Corso Lisette, Delitala Giuseppe, Denegri Andrea, Di Cesare Valentina, Di Giosia Paolo, Di Michele Dario, Di Minno Giovanni, Donnarumma Emilia, Drenaggi Davide, Durante-Mangoni Emanuele, Falsetti Lorenzo, FarcomeniAlessio, FarinaroVincenza, Fasolato Silvano, Ferrari Giovanni, Fierro Tiziana, Forgione Alessandra, Frugiuele Pierluigi, Galati Giovanni, Gallo Paolo, Garcovich Matteo, Gargano Ruggiero, Gasbarrini Antonio, Gatta Angelo, Giammanco Antonina, Giannelli Gianluigi, Giorgini Paolo, Gobbi Paolo, Granito Alessandro, GrassiDavide, Greco Antonio, Grembiale Alessandro, Gresele Paolo, Hijazi Daniel, Iacobellis, Angelo, Iamele Luigi, Invernizzi Pietro, Ippolito Antonio, Laffi, Giacomo, Licata Anna, Liguori Maria Livia, Lorusso Giusi, Maimone Sergio, Manfredini Roberto, Marcacci Matteo, Marchese Alessandra, Marinelli Sara, Marra Alberto Maria, Martino Giuseppe Pio, Masala Maristella, Masotti Michela, Merla Antonio, Miceli Giuseppe, Montebianco Abenavoli Ludovico, Morana Ignazio, Morelli Olivia, Murgia Giuseppe, Naccarato Paola, Neri Sergio, Niro Grazia, Nobili Lorenzo, Padula Donatella, PalascianoGiuseppe, PalmieriVincenzoOstilio, PastoriDaniele, Pattoneri Paolo, Perego Francesca, Perticone Maria, Pesce Paola, Petramala Luigi, Pettinari Irene, Piano Salvatore, Picardi Antonio, Pignataro Francesca Serena, Pignataro Pietro, Pignatelli Pasquale, PinnaMiriam, Pinto Antonio, Pinto Daniela, Polimeni Licia, Pretti Vincenzo, Privitera Graziella, Proietti Marco, Pucci Giacomo, Purrello Francesco, Ragone Enrico, Raimondo Giovanni, Restuccia Tea, Riccardi Laura, RizzettoMario, Rodríguez- Castro Kryssia Isabel, Romanelli Roberto Giulio, Ruscio Eleonora, Sacerdoti David, Salinaro Francesco, Salvi Aldo, Salzano Andrea, SantangeloGiuseppe, Santarossa Claudia, Santilli Francesca, Santovito Daniela, Scarpini Francesca, Schiavone Cosima, Scicali Roberto, SenzoloMarco, Serra Carla, Serviddio Gaetano, Sirico Domenico, Soresi Maurizio, Sperduti Nicolò, Staffolani Silvia, Staltari Orietta, Stasi Cristina, Suppressa Patrizia, Svegliati Baroni Gianluca, Talia Michela, Tana Claudio, Tassone Eliezer Joseph, Todisco Tommaso, Toriello Filippo, Torres Daniele, Traversa Matteo, Tripepi Giovanni, Tufano Antonella, Tuttolomondo Antonino, Varvara Doriana, Vazzana Natale, Vecchio Claudia Rita, Vendemiale Gianluigi, Ventura Paolo, Vespasiani-Gentilucci Umberto, Vettore Elia, Vidili Gianpaolo, Villani Rosanna, Vincenzo Ronca, Visioli Giacomo, Vitale Francesco, Zocco Maria Assunta.

Subjects
Liver Cirrhosis, Male, medicine.medical_specialty, Letter to the editor, Time Factors, MEDLINE, Portal Vein Thrombosis Cirrhotic Patients, outcomes, NO, coagulopathy, Recurrence, Risk Factors, Medicine, Humans, Aged, Female, Incidence, Italy, Middle Aged, Prospective Studies, Registries, Ultrasonography, Doppler, Venous Thrombosis, Portal Vein, portal vein thrombosis, Prospective cohort study, risk-factors, liver-transplantation, mortality, Ultrasonography, business.industry, Incidence (epidemiology), portal vein thrombosis, liver-transplantation, risk-factors, coagulopathy, mortality, outcomes, Doppler, Hematology, medicine.disease, Portal vein thrombosis, Radiology, business
Abstract

Cirrhosis has been long considered a risk factor for bleeding due to the co-existence of the so-called ‘coagulopathy’. More recently, however, compelling evidences have been provided on the occurrence of thrombotic events in the portal and systemic circulation.3–5 Portal vein thrombosis (PVT) is predominantly observed in patients with moderate to severe liver failure with a variable prevalence ranging from 0.6 to 25%. Only fewstudies have provided a longitudinal assessment of the PVT incidence and its sequelae, including recurrence and survival.9–14 Due to the variability of PVT incidence and the paucity of data regarding recurrence and survival,15–20 we prospectively analysed the incidence and the recurrence of PVT in the population of Portal vein thrombosis Relevance On Liver cirrhosis: ItalianVenous thromboticEventsRegistry (PROLIVER), a multi-centre study,8 which involved 43 enrolling centres in Italy (ClinicalTrials.gov Identifier: NCT01470547).

Published
2019

36. Liver histopathological findings in advanced heart failure: a reappraisal of cardiac cirrhosis concept

Author

Cristiano Amarelli, Pia Clara Pafundi, Rosa Zampino, Martina Vitrone, Antonio Parrella, Enrico Ragone, Emanuele Durante-Mangoni, Ilaria De Rosa, Durante-Mangoni, Emanuele, Parrella, Antonio, Pafundi, Pia Clara, Vitrone, Martina, Ragone, Enrico, De Rosa, Ilaria, Amarelli, Cristiano, and Zampino, Rosa

Subjects
Adult, Male, medicine.medical_specialty, Cirrhosis, Biopsy, Pilot Projects, Heart failure, 030204 cardiovascular system & hematology, Gastroenterology, Statistics, Nonparametric, 03 medical and health sciences, Liver disease, 0302 clinical medicine, Fibrosis, Internal medicine, medicine, Internal Medicine, Humans, 030212 general & internal medicine, Retrospective Studies, Ultrasonography, Liver injury, medicine.diagnostic_test, business.industry, Cardiac cirrhosi, Liver ultrasound, Heparin, Low-Molecular-Weight, Middle Aged, Liver biopsy, medicine.disease, Liver, Emergency Medicine, Female, Complication, Viral hepatitis, business
Abstract

Cardiogenic liver disease is a common yet poorly characterized complication of advanced heart failure (HF), and may impact clinical management in the setting of heart transplant evaluation. In this retrospective study, we describe clinical and histopathological features of liver injury in advanced HF, with a focus on the role of liver biopsy. Included were 45 HF patients, assessed for possible heart transplant, who underwent liver biopsy for suspected liver disease. Median duration of HF symptoms was 5years. Most patients had stiff hepatomegaly and elevated bilirubin. Viral hepatitis (19 patients, 42.2%) was the most common cause of prior known liver disease. Sinusoidal dilatation was detected in the majority of patients (64.4%). Median necroinflammatory index was 3 and median fibrosis was 1, consistent with a small burden of histologically proven liver disease. Viral hepatitis was the only variable associated with a higher grade of necroinflammation and fibrosis. Nine of the 14 (64.3%) advanced fibrosis/cirrhosis patients had a viral hepatitis infection. Fibrosis was significantly associated with splenomegaly. The MELD score was not correlated with cardiac index. A coarse liver echo-pattern had a 29% positive and 63% negative predictive value for advanced fibrosis/cirrhosis. Severe liver disease is uncommon in patients with advanced HF in the absence of splenomegaly or primary causes of liver disease. Ultrasound data need to be carefully evaluated, as it may overstate the severity of liver disease. Liver biopsy may be needed to accurately stage liver disease before excluding patients from advanced treatment strategies.

Published
2019

37. Can we go for a shorter treatment course in chronic hepatitis C? More inspiring cases

Author

Antonio Parrella, Enrico Ragone, Martina Vitrone, Rosa Zampino, Emanuele Durante-Mangoni, Zampino, Rosa, Vitrone, Martina, Parrella, Antonio, Ragone, Enrico, and Durante-Mangoni, Emanuele

Subjects
Male, Pediatrics, medicine.medical_specialty, Time Factors, Hcv therapy, Hepacivirus, Antiviral Agents, Treatment duration, Disease course, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Chronic hepatitis, medicine, Humans, Pharmacology (medical), 030212 general & internal medicine, DAA, Pharmacology, Dasabuvir, business.industry, Ribavirin, Medicine (all), virus diseases, Hepatitis C, Chronic, Middle Aged, Prognosis, Ombitasvir, Surgery, Infectious Diseases, chemistry, Oncology, Paritaprevir, HCV treatment, 030211 gastroenterology & hepatology, Ritonavir, Drug Therapy, Combination, Female, business, medicine.drug
Abstract

Current interest in HCV therapy with direct acting antivirals is focused on shortening treatment length. We managed two cirrhotics who achieved virological cure after 4Â weeks of ombitasvir/paritaprevir/ritonavir, dasabuvir, ribavirin treatment. Analysis to identify potential predictive factors for a successful outcome with a shorter treatment course was conducted.

Published
2018

38. Final Results from the First European Real-World Experience on Lusutrombopag Treatment in Cirrhotic Patients with Severe Thrombocytopenia: Insights from the REAl-World Lusutrombopag Treatment in ITalY Study.

Author

Gallo P, De Vincentis A, Terracciani F, Falcomatà A, Pace Palitti V, Russello M, Vignone A, Alvaro D, Tortora R, Biolato M, Pompili M, Calvaruso V, Marzia V, Tizzani M, Caneglias A, Frigo F, Gesualdo M, Marzano A, Rosato V, Claar E, Villani R, Izzi A, Cozzolongo R, Cozzolino A, Airoldi A, Mazzarelli C, Distefano M, Iegri C, Fagiuoli S, Messina V, Ragone E, Sacco R, Cacciatore P, Masutti F, Crocé SL, Moretti A, Flagiello V, Di Pasquale G, Picardi A, and Vespasiani-Gentilucci U

Abstract

Background and aims: Management of severe thrombocytopenia poses significant challenges in patients with chronic liver disease. Here, we aimed to evaluate the first real-world European post-marketing cohort of cirrhotic patients treated with lusutrombopag, a thrombopoietin receptor agonist, verifying the efficacy and safety of the drug. Methods: In the REAl-world Lusutrombopag treatment in ITalY (REALITY) study, we collected data from consecutive cirrhotic patients treated with lusutrombopag in 19 Italian hepatology centers, mostly joined to the "Club Epatologi Ospedalieri" (CLEO). Primary and secondary efficacy endpoints were the ability of lusutrombopag to avoid platelet transfusions and to raise the platelet count to ≥50,000/μL, respectively. Treatment-associated adverse events were also collected. Results: A total of 66 patients and 73 cycles of treatment were included in the study, since 5 patients received multiple doses of lusutrombopag over time for different invasive procedures. Fourteen patients (19%) had a history of portal vein thrombosis (PVT). Lusutrombopag determined a significant increase in platelet count [from 37,000 (33,000-44,000/μL) to 58,000 (49,000-82,000), p < 0.001]. The primary endpoint was met in 84% of patients and the secondary endpoint in 74% of patients. Baseline platelet count was the only independent factor associated with response in multivariate logistic regression analysis (OR for any 1000 uL of 1.13, CI95% 1.04-1.26, p 0.01), with a good discrimination power (AUROC: 0.78). Notably, a baseline platelet count ≤ 29,000/μL was identified as the threshold for identifying patients unlikely to respond to the drug (sensitivity of 91%). Finally, de novo PVT was observed in four patients (5%), none of whom had undergone repeated treatment, and no other safety or hemorrhagic events were recorded in the entire population analyzed. Conclusions: In this first European real-world series, lusutrombopag demonstrated efficacy and safety consistent with the results of registrational studies. According to our results, patients with baseline platelet counts ≤29,000/μL are unlikely to respond to the drug.

Published
2024
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39. Can we go for a shorter treatment course in chronic hepatitis C? More inspiring cases.

Author

Zampino R, Vitrone M, Parrella A, Ragone E, and Durante-Mangoni E

Subjects
Drug Therapy, Combination, Female, Hepacivirus isolation & purification, Hepatitis C, Chronic microbiology, Humans, Male, Middle Aged, Prognosis, Time Factors, Antiviral Agents therapeutic use, Hepacivirus drug effects, Hepatitis C, Chronic drug therapy
Abstract

Current interest in HCV therapy with direct acting antivirals is focused on shortening treatment length. We managed two cirrhotics who achieved virological cure after 4 weeks of ombitasvir/paritaprevir/ritonavir, dasabuvir, ribavirin treatment. Analysis to identify potential predictive factors for a successful outcome with a shorter treatment course was conducted.

Published
2018
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40. Risk factors for "major" embolic events in hospitalized patients with infective endocarditis.

Author

Durante Mangoni E, Adinolfi LE, Tripodi MF, Andreana A, Gambardella M, Ragone E, Precone DF, Utili R, and Ruggiero G

Subjects
Adolescent, Adult, Aged, Analysis of Variance, C-Reactive Protein analysis, Child, Embolism epidemiology, Endocarditis, Bacterial pathology, Female, Heart Valve Diseases microbiology, Heart Valve Diseases pathology, Humans, Male, Middle Aged, Multivariate Analysis, Prospective Studies, Risk Factors, Serum Albumin analysis, Embolism etiology, Endocarditis, Bacterial complications, Heart Valve Diseases complications
Abstract

Background: Infective endocarditis often is complicated by embolic events after hospital admission. Identifying patients at higher risk may improve the disease outcome. This study was aimed at identifying predictors of embolic risk among the clinical and laboratory data obtained on hospital admission in patients diagnosed as having definite infective endocarditis according to the Duke criteria., Methods: Ninety-four patients were enrolled in a prospective study. The results of hematologic, echocardiographic, and microbiological investigations were analyzed, using statistical methods as appropriate. Multivariate analysis was applied to variables significantly associated with embolism in univariate analysis., Results: Forty-six percent of patients had a major embolic complication after admission. No association was found between embolism and sex, site of infection, or microorganism involved. Patients with embolism were significantly younger, had larger vegetation, and showed a significantly higher level of serum C-reactive protein and lower albumin concentrations than those without embolism. Young age, larger vegetation size, and high levels of C-reactive protein were the independent variables associated with an increased incidence of embolic events in the multivariate logistic regression analysis., Conclusions: Our data indicate that patients with infective endocarditis with young age and/or with large vegetation and/or with high serum levels of C-reactive protein are at increased risk of major embolic complications during the in-hospital course of the disease.

Published
2003
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