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4 results on '"Rait, Dzhessi"'

1. Neuron-astrocyte transmitophagy is altered in Alzheimer's disease

Author

Lampinen, Riikka, Belaya, Irina, Saveleva, Liudmila, Liddell, Jeffrey R., Rait, Dzhessi, Huuskonen, Mikko T., Giniatullina, Raisa, Sorvari, Annika, Soppela, Liisi, Mikhailov, Nikita, Boccuni, Isabella, Giniatullin, Rashid, Cruz-Haces, Marcela, Konovalova, Julia, Koskuvi, Marja, Domanskyi, Andrii, Hämäläinen, Riikka H., Goldsteins, Gundars, Koistinaho, Jari, Malm, Tarja, Chew, Sweelin, Rilla, Kirsi, White, Anthony R., Marsh-Armstrong, Nicholas, and Kanninen, Katja M.

Published
2022
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2. Novel Anti-Neuroinflammatory Properties of a Thiosemicarbazone–Pyridylhydrazone Copper(II) Complex

Author

Choo, Xin Yi, primary, McInnes, Lachlan E., additional, Grubman, Alexandra, additional, Wasielewska, Joanna M., additional, Belaya, Irina, additional, Burrows, Emma, additional, Quek, Hazel, additional, Martín, Jorge Cañas, additional, Loppi, Sanna, additional, Sorvari, Annika, additional, Rait, Dzhessi, additional, Powell, Andrew, additional, Duncan, Clare, additional, Liddell, Jeffrey R., additional, Tanila, Heikki, additional, Polo, Jose M., additional, Malm, Tarja, additional, Kanninen, Katja M., additional, Donnelly, Paul S., additional, and White, Anthony R., additional

Published
2022
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3. Neuron-astrocyte transmitophagy is altered in Alzheimer's disease

Author

Lampinen, Riikka, Belaya, Irina, Saveleva, Liudmila, Liddell, Jeffrey R., Rait, Dzhessi, Huuskonen, Mikko T., Giniatullina, Raisa, Sorvari, Annika, Soppela, Liisi, Mikhailov, Nikita, Boccuni, Isabella, Giniatullin, Rashid, Cruz-Haces, Marcela, Konovalova, Julia, Koskuvi, Marja, Domanskyi, Andrii, Hämäläinen, Riikka H., Goldsteins, Gundars, Koistinaho, Jari, Malm, Tarja, Chew, Sweelin, Rilla, Kirsi, White, Anthony R., Marsh-Armstrong, Nicholas, Kanninen, Katja M., Institute of Biotechnology, Biosciences, and Neuroscience Center

Subjects
EXPRESSION, Neurons, MITOCHONDRIAL DYSFUNCTION, Amyloid beta-Peptides, Mitophagy, Alzheimer's disease, PARKIN, Mitochondria, MODEL, Mice, Alzheimer Disease, Astrocytes, S100A4, 1182 Biochemistry, cell and molecular biology, Animals, AUTOPHAGY, Transmitophagy, ACCUMULATION
Abstract

Under physiological conditions in vivo astrocytes internalize and degrade neuronal mitochondria in a process called transmitophagy. Mitophagy is widely reported to be impaired in neurodegeneration but it is unknown whether and how transmitophagy is altered in Alzheimer's disease (AD). Here we report that the internalization of neuronal mitochondria is significantly increased in astrocytes isolated from AD mouse brains. We also demonstrate that the degradation of neuronal mitochondria by astrocytes is increased in AD mice at the age of 6 months onwards. Furthermore, we demonstrate for the first time a similar phenomenon between human neurons and AD astrocytes, and in murine hippocampi in vivo. The results suggest the involvement of S100a4 in impaired mitochondrial transfer between neurons and AD astrocytes together with significant increases in the mitophagy regulator and reactive oxygen species in aged AD astrocytes. These findings demonstrate altered neuronsupporting functions of AD astrocytes and provide a starting point for studying the molecular mechanisms of transmitophagy in AD.

Published
2021

4. Alzheimer's disease alters astrocytic functions related to neuronal support and transcellular internalization of mitochondria

Author

Lampinen, Riikka, primary, Belaya, Irina, additional, Saveleva, Liudmila, additional, Liddell, Jeffrey R, additional, Rait, Dzhessi, additional, Huuskonen, Mikko T, additional, Giniatullina, Raisa, additional, Sorvari, Annika, additional, Soppela, Liisi, additional, Mikhailov, Nikita, additional, Boccuni, Isabella, additional, Giniatullin, Rashid, additional, Cruz-Haces, Marcela, additional, Konovalova, Julia, additional, Koskuvi, Marja, additional, Rauramaa, Tuomas, additional, Domanskyi, Andrii, additional, Hamalainen, Riikka H, additional, Goldsteins, Gundars, additional, Koistinaho, Jari, additional, Malm, Tarja, additional, Chew, Sweelin, additional, Rilla, Kirsi, additional, White, Anthony R, additional, Marsh-Armstrong, Nicholas, additional, and Kanninen, Katja M, additional

Published
2021
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