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1. Contents Vol. 116, 2006

Author

Yurie Saitoh, Manuela Leo, Rie Imamura, Paola Carluccio, Raj Rangineni, Giorgina Specchia, Ritsuko Seki, Kazuei Ogawa, Ioannis Stefanidis, Ernest Beutler, Rívia Mara Morais e Silva, Theodoros Eleftheriadis, Christian Breymann, Michio Sata, Jonathan M. Flanagan, Georgia Antoniadi, Yukio Maruyama, Michitoshi Hashiguchi, Terri Gelbart, Tilo Burkhardt, Domenico Pastore, Hideaki Ogata, Arcangelo Liso, Rokuo Abe, Takashi Okamura, Maria Ditsa, Margherita Giannoccaro, Kohji Yoshimoto, Silvia Sibilla, Fernando Coutinho, Koichi Osaki, Maria das Graças Carvalho, Lei Wang, Ana Rita Manhani, Vassilios Liakopoulos, Eijiro Oku, Eiji Ando, Gabriela Bencaiova, Hiroaki Nagamatsu, Ashok Kumar Malani, Auro Del Giglio, Dimitra Markala, Anna Mestice, Margherita Casanova, Charalambos Kartsios, Pauline Lee, Tsutomu Shichishima, Vicram Gupta, Geraldo Majella Medeiros de Paula, Kazuaki Yakushiji, Vânia Maria Freitas, Hongfan Peng, G. Anifandis, André Aleixo Pereira Hipólito Dantas, Alexander Krafft, Vincenzo Liso, Luci Maria Sant'Ana Dusse, Barbra Sasu, Christos Papadopoulos, Aliki Skirta, Kazuhide Shimamatsu, Lauro Mello Vieira, and Korenori Ohtsubo

Subjects
Hematology, General Medicine
Published
2006
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2. Bortezomib and dexamethasone in previously untreated multiple myeloma associated with renal failure and reversal of renal failure

Author

Ashok K. Malani, Raj Rangineni, and Vicram Gupta

Subjects
Oncology, Male, medicine.medical_specialty, urologic and male genital diseases, Dexamethasone, Bortezomib, immune system diseases, hemic and lymphatic diseases, Internal medicine, Medicine, Humans, Renal Insufficiency, Intensive care medicine, Multiple myeloma, Aged, Salvage Therapy, business.industry, Hematology, General Medicine, Middle Aged, medicine.disease, Boronic Acids, Drug indicated, Treatment Outcome, Proteasome, Pyrazines, Drug Therapy, Combination, Female, business, Multiple Myeloma, medicine.drug
Abstract

Multiple myeloma (MM) associated with renal failure carries a worse prognosis when compared with MM without renal failure. Bortezomib, a reversible proteosome inhibitor, is a new drug indicated for the treatment of refractory or relapsed myeloma. Published data on the use of bortezomib in patients with myeloma and renal failure are few. We report our experience with bortezomib and dexamethasone in 3 previously untreated and 1 relapsed patient with MM and renal failure. All patients achieved rapid improvement in their renal function as measured by serum creatinine levels with only 1–2 cycles of bortezomib (± dexamethasone), 3 of 4 patients had a near complete response and 1 patient had a partial response. The rapid reversal of renal dysfunction with bortezomib (± dexamethasone) treatment may be an effective strategy to prevent end stage renal failure in MM, thereby improving the morbidity and mortality in this otherwise poor prognosis subset of patients with myeloma.

Published
2006

3. Subject Index Vol. 116, 2006

Author

Raj Rangineni, Michio Sata, Theodoros Eleftheriadis, Christian Breymann, Ashok K. Malani, Anna Mestice, Lei Wang, Kazuaki Yakushiji, Terri Gelbart, Maria Ditsa, Charalambos Kartsios, Ana Rita Manhani, Rokuo Abe, Eiji Ando, Rívia Mara Morais e Silva, Hongfan Peng, Eijiro Oku, Maria das Graças Carvalho, Rie Imamura, Dimitra Markala, Ritsuko Seki, Kazuei Ogawa, Auro Del Giglio, Paola Carluccio, Yurie Saitoh, Hideaki Ogata, Yukio Maruyama, Michitoshi Hashiguchi, G. Anifandis, Giorgina Specchia, Lauro Mello Vieira, Hiroaki Nagamatsu, Tilo Burkhardt, Margherita Giannoccaro, Georgia Antoniadi, Manuela Leo, Kohji Yoshimoto, Ioannis Stefanidis, Domenico Pastore, Jonathan M. Flanagan, Silvia Sibilla, Ernest Beutler, Vassilios Liakopoulos, Luci Maria Sant'Ana Dusse, Christos Papadopoulos, Gabriela Bencaiova, Vânia Maria Freitas, Takashi Okamura, Fernando Coutinho, Margherita Casanova, Geraldo Majella Medeiros de Paula, Pauline Lee, Tsutomu Shichishima, Alexander Krafft, Vincenzo Liso, Arcangelo Liso, Barbra Sasu, Kazuhide Shimamatsu, Vicram Gupta, Koichi Osaki, Korenori Ohtsubo, Aliki Skirta, and André Aleixo Pereira Hipólito Dantas

Subjects
Index (economics), Statistics, Subject (documents), Hematology, General Medicine, Mathematics
Published
2006
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