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The research is aimed to assess the joint antibacterial effects of hydrogen peroxide and methanolic stem extract (SNP-MSE)-prepared silver nanoparticles against Klebsiella pneumoniae. Utilizing MSE under sunlight, biogenic silver nanoparticles were produced, with their properties characterised using FTIR and UV-Visible spectroscopies. Turbidimetry determined the Minimum Inhibitory Concentration (MIC) of SNP-MSE, H2O2, and their varied combinations at different concentrations. Agar well diffusion assessed the zone of inhibition. The study comprised three groups: Group 1 assessed SNP-MSE, Group 2 H2O2, and Group 3 their combination. A sample size of 9 (3 per group) was determined with an 80% pretest G power. At 1 μg/ml SNP-MSE, no inhibition zone was observed; for 0.625 mM H2O2, it measured 7.81 ± 0.464 mm; and for the combined treatment, 14.01 ± 0.478 mm. The combined treatment significantly (p=

In the present work, 16 different plant drugs used by traditional healers from West Bengal were screened through in vitro cell line model. Herbal drugs used by traditional tribal healers in Purulia, Birbhum and Bankura districts of West Bengal were collected and screening against acute myeloid leukemia (AML) cell line (HL-60). Among 16 plant extracts, bark of Flacourtia indica (66.67%), leaf of Madhuca longifolia (69.17%), and leaf of Prosopis cineraria (68.08%) showed better cytotoxicity results than other herbals. Further, time-dependent study showed maximum cytotoxicity of the selected herbal extracts between 36 and 48 hours of treatment in both acute and chronic myeloid leukemia (CML) cell lines (HL-60 and K562). The LC-MS/MS analysis of the selected drugs revealed the presence of picrotoxinin and 10-deacetylbaccatin from F. indica, isoorientin and hirsutrin from M. longifolia, vitexin and rhoifolin in P. cineraria. [ABSTRACT FROM AUTHOR]

The present study portrays the isolation of four phenylpropanoids – ferulic acid (FA), sinapic acid (SA), caffeic acid (CA), and chlorogenic acid (CHA) from the water extract ofSuaeda maritima(L.) Dumort, a phytochemically less explored Indian medicinal plant. Further, synthesis and characterization of silver and gold nanoparticles using the isolated phenylpropanoids were done. The silver nanoparticles synthesized fromS. maritimawater extract along with silver nano-conjugated forms of the isolated compounds exhibited appreciable anti-leukemic activity against K562 cells (human myeloid leukemia). Especially, the ferulic and CA-conjugated silver nanoparticles showed significant (P < .01) activity against leukemia. [ABSTRACT FROM AUTHOR]