1. Diagnostic Performance of a Novel Three-Dimensional Neuroretinal Rim Parameter for Glaucoma Using High-Density Volume Scans
- Author
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Johannes F. de Boer, Teresa C. Chen, Christian Que, Sumir Pandit, Edem Tsikata, Eric Shieh, Rajini Seevaratnam, Vivek J. Srinivasan, Huseyin Simavli, Rong Guo, Regina DeLuna, Ramon Lee, Biophotonics and Medical Imaging, Amsterdam Neuroscience - Brain Imaging, and LaserLaB - Biophotonics and Microscopy more...
- Subjects
Male ,Retinal Ganglion Cells ,0301 basic medicine ,Intraocular pressure ,medicine.medical_specialty ,genetic structures ,Optic Disk ,Optic disk ,Glaucoma ,Sensitivity and Specificity ,Tonometry, Ocular ,03 medical and health sciences ,Imaging, Three-Dimensional ,Nerve Fibers ,0302 clinical medicine ,Optical coherence tomography ,Predictive Value of Tests ,Ophthalmology ,Positive predicative value ,Optic Nerve Diseases ,medicine ,Humans ,False Positive Reactions ,Intraocular Pressure ,Aged ,Mathematics ,medicine.diagnostic_test ,Receiver operating characteristic ,Middle Aged ,medicine.disease ,Healthy Volunteers ,eye diseases ,030104 developmental biology ,ROC Curve ,Area Under Curve ,Predictive value of tests ,030221 ophthalmology & optometry ,Optometry ,Female ,Tomography ,sense organs ,Glaucoma, Open-Angle ,Tomography, Optical Coherence - Abstract
© 2016 Elsevier Inc. Purpose To evaluate the diagnostic performance of a 3-dimensional (3D) neuroretinal rim parameter, the minimum distance band (MDB), using optical coherence tomography (OCT) high-density volume scans for open-angle glaucoma. Design Reliability analysis. Methods SETTING: Institutional. STUDY POPULATION: Total of 163 patients (105 glaucoma and 58 healthy subjects). OBSERVATION PROCEDURES: One eye of each patient was included. MDB and retinal nerve fiber layer (RNFL) thickness values were determined for 4 quadrants and 4 sectors using a spectral-domain OCT device. MAIN OUTCOME MEASURES: Area under the receiver operating characteristic curve (AUROC) values, sensitivities, specificities, and positive and negative predictive values. Results The best AUROC values of 3D MDB thickness for glaucoma and early glaucoma were for the overall globe (0.969, 0.952), followed by the inferior quadrant (0.966, 0.949) and inferior-temporal sector (0.966, 0.944), and then followed by the superior-temporal sector (0.964, 0.932) and superior quadrant (0.962, 0.924). All 3D MDB thickness AUROC values were higher than those of 2D RNFL thickness. Pairwise comparisons showed that the diagnostic performance of the 3D MDB parameter was significantly better than 2D RNFL thickness only for the nasal quadrant and inferior-nasal and superior-nasal sectors (P = .023–.049). Combining 3D MDB with 2D RNFL parameters provided significantly better diagnostic performance (AUROC 0.984) than most single MDB parameters and all single RNFL parameters. Conclusions Compared with the 2D RNFL thickness parameter, the 3D MDB neuroretinal rim thickness parameter had uniformly equal or better diagnostic performance for glaucoma in all regions and was significantly better in the nasal region. more...
- Published
- 2016
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