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Pseudomonas aeruginosa (P. aeruginosa) is an opportunistic pathogen with a high morbidity andmortality rate in immunocompromised and cystic fibrosis patients. The treatment of P. aeruginosa infections is becoming increasingly difficult due to the bacteria's capacity to tolerate numerous antimicrobial agent. One of the key mechanisms of antimicrobial resistance (AMR) in P. aeruginosa that contributes to both innate and acquired resistance is the efflux pump system Understanding the structure, function, and control of the main efflux pump system, specifically the resistance nodulation division superfamily, iscritical. This could provide baseline data for the development of a new antibacterial that targets this crucial resistance pathway in P. aeruginosa, thereby halting or slowing morbidity and death associated with AMR.