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916 results on '"Ramadori, Giuliano"'

12. Hepatocytes

Author

Ramadori, Giuliano, Saile, Bernhard, Dufour, Jean-François, editor, Clavien, Pierre-Alain, editor, Trautwein, Christian, editor, and Graf, Rolf, editor

Published
2005
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18. Cytokines

Author

Ramadori, Giuliano, Armbrust, Thomas, Strain, Alastair, editor, and Diehl, Anne Mae, editor

Published
1998
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25. PECAM‐1 modulates liver damage induced by synergistic effects of TNF‐α and irradiation

Author

Malik, Gesa, Wilting, Jörg, Hess, Clemens Friedrich, Ramadori, Giuliano, and Malik, Ihtzaz Ahmed

Subjects
RILD, Male, Mice, Knockout, STAT3 Transcription Factor, Tumor Necrosis Factor-alpha, lipocalin-2, Antigens, Differentiation, Myelomonocytic, Original Articles, cytokines, Mice, Inbred C57BL, Platelet Endothelial Cell Adhesion Molecule-1, Kinetics, Liver, inflammation, Antigens, CD, Radiation, Ionizing, Leukocytes, Animals, Original Article, CD31, Aspartate Aminotransferases, RNA, Messenger, Phosphorylation
Abstract

The mechanisms of radiation‐induced liver damage are poorly understood. We investigated if tumour necrosis factor (TNF)‐α acts synergistically with irradiation, and how its activity is influenced by platelet endothelial cell adhesion molecule‐1 (PECAM‐1). We studied murine models of selective single‐dose (25 Gy) liver irradiation with and without TNF‐α application (2 μg/mouse; i.p.). In serum of wild‐type (wt)‐mice, irradiation induced a mild increase in hepatic damage marker aspartate aminotransferase (AST) in comparison to sham‐irradiated controls. AST levels further increased in mice treated with both irradiation and TNF‐α. Accordingly, elevated numbers of leucocytes and increased expression of the macrophage marker CD68 were observed in the liver of these mice. In parallel to hepatic damage, a consecutive decrease in expression of hepatic PECAM‐1 was found in mice that received radiation or TNF‐α treatment alone. The combination of radiation and TNF‐α induced an additional significant decline of PECAM‐1. Furthermore, increased expression of hepatic lipocalin‐2 (LCN‐2), a hepatoprotective protein, was detected at mRNA and protein levels after irradiation or TNF‐α treatment alone and the combination of both. Signal transducer and activator of transcription‐3 (STAT‐3) seems to be involved in the signalling cascade. To study the involvement of PECAM‐1 in hepatic damage more deeply, the liver of both wt‐ and PECAM‐1‐knock‐out‐mice were selectively irradiated (25 Gy). Thereby, ko‐mice showed higher liver damage as revealed by elevated AST levels, but also increased hepatoprotective LCN‐2 expression. Our studies show that TNF‐α has a pivotal role in radiation‐induced hepatic damage. It acts in concert with irradiation and its activity is modulated by PECAM‐1, which mediates pro‐ and anti‐inflammatory signalling.

Published
2019

44. Risk factors for gastrointestinal stromal tumor recurrence in patients treated with adjuvant imatinib

Author

Joensuu, Heikki, Eriksson, Mikael, Hall, Kirsten Sundby, Hartmann, Jörg T., Pink, Daniel, Schütte, Jochen, Ramadori, Giuliano, Hohenberger, Peter, Duyster, Justus, Al-Batran, Salah-Eddin, Schlemmer, Marcus, Bauer, Sebastian, Wardelmann, Eva, Sarlomo-Rikala, Maarit, Nilsson, Bengt, Sihto, Harri, Ballman, Karla V., Leinonen, Mika, DeMatteo, Ronald P., and Reichardt, Peter

Published
2014
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