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Your search keyword '"Ramalingam, Sendhilnathan"' showing total 27 results
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27 results on '"Ramalingam, Sendhilnathan"'

1. Timing of allogeneic hematopoietic cell transplantation for myelofibrosis and other myeloproliferative neoplasms.

Author

Mercer, Joshua S., primary, Bradbury, Claire I., additional, Thomas, Samantha M., additional, Ramalingam, Sendhilnathan, additional, Gasparetto, Cristina, additional, Choi, Taewoong, additional, Sung, Anthony D., additional, Sarantopoulos, Stefanie, additional, Long, Gwynn Douglas, additional, Alyea, Edwin, additional, Horwitz, Mitchell E., additional, Chao, Nelson Jen An, additional, and Hong, Sanghee, additional

Published
2024
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2. Acceptance and Commitment Therapy May Improve Physical Function after Allogeneic Hematopoietic Stem Cell Transplant

Author

Infield, Jordan, primary, Smith, Patrick J, additional, Merwin, Rhonda M, additional, Racioppi, Alessandro, additional, O'Connell, Christine, additional, Taylor, Allison O., additional, Hill, Lauren, additional, Winthrop, Hilary, additional, Alyea, Edwin P, additional, Chao, Nelson J., additional, Choi, Taewoong, additional, Gasparetto, Cristina, additional, Hong, Sanghee, additional, Horwitz, Mitchell, additional, Kang, Yubin, additional, Long, Gwynn D, additional, Lopez, Richard D, additional, Ramalingam, Sendhilnathan, additional, Sarantopoulos, Stefanie, additional, and Sung, Anthony D, additional

Published
2024
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5. Fecal microbiota diversity disruption and clinical outcomes after auto-HCT: a multicenter observational study

Author

Khan, Niloufer, Lindner, Sarah, Gomes, Antonio L.C., Devlin, Sean M., Shah, Gunjan L., Sung, Anthony D., Sauter, Craig S., Landau, Heather J., Dahi, Parastoo B., Perales, Miguel-Angel, Chung, David J., Lesokhin, Alexander M., Dai, Anqi, Clurman, Annelie, Slingerland, John B., Slingerland, Ann E., Brereton, Daniel G., Giardina, Paul A., Maloy, Molly, Armijo, Gabriel K., Rondon-Clavo, Carlos, Fontana, Emily, Bohannon, Lauren, Ramalingam, Sendhilnathan, Bush, Amy T., Lew, Meagan V., Messina, Julia A., Littmann, Eric, Taur, Ying, Jenq, Robert R., Chao, Nelson J., Giralt, Sergio, Markey, Kate A., Pamer, Eric G., van den Brink, Marcel R.M., and Peled, Jonathan U.

Published
2021
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6. Geriatric Assessment Reveals Actionable Impairments in Hematopoietic Stem Cell Transplantation Candidates Age 18 to 80 Years

Author

Lew, Meagan V., Ren, Yi, Lowder, Yen P., Siamakpour-Reihani, Sharareh, Ramalingam, Sendhilnathan, Romero, Kristi M., Thompson, Jillian C., Bohannon, Lauren M., McIntyre, Jackie, Tang, Helen, Van Opstal, Jolien, Johnson, Ernaya, Cohen, Harvey Jay, Bartlett, David B., Pastva, Amy M., Morey, Miriam, Hall, Katherine S., Smith, Patrick, Peters, Katherine B., Somers, Tamara J., Kelleher, Sarah, Smith, Sophia K., Wischmeyer, Paul E., Lin, Pao-Hwa, Wood, William A., Thorpe, Glynnis, Minor, Kerry, Wiggins, Kristi, Hennig, Therese, Helms, Tanya, Welch, Renee, Matthews, Brittany, Liu, JoAnn, Burleson, Jill, Aberant, Thomas, Engemann, Ashley K., Henshall, Bethany, Darby, Maurisa, Proch, Christina, Dellascio, Michelle, Pittman, Alyssa, Suminguit, Jacob, Choi, Taewoong, Gasparetto, Cristina, Long, Gwynn D., Lopez, Richard D., Sarantopoulos, Stefanie, Horwitz, Mitchell E., Chao, Nelson J., and Sung, Anthony D.

Published
2022
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9. Assessing the Feasibility of a Novel mHealth App in Hematopoietic Stem Cell Transplant Patients

Author

Racioppi, Alessandro, Dalton, Tara, Ramalingam, Sendhilnathan, Romero, Kristi, Ren, Yi, Bohannon, Lauren, Arellano, Consuelo, Jonassaint, Jude, Miller, Hilary, Barak, Ian, Fish, Laura J., Choi, Taewoong, Gasparetto, Cristina, Long, Gwynn D., Lopez, Richard D., Rizzieri, David A., Sarantopoulos, Stefanie, Horwitz, Mitchell E., Chao, Nelson J., Shah, Nirmish R., and Sung, Anthony D.

Published
2021
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11. Cognitive impairment in candidates for allogeneic hematopoietic stem cell transplantation

Author

Smith, Patrick J., primary, Lew, Meagan, additional, Lowder, Yen, additional, Romero, Kristi, additional, Thompson, Jillian C., additional, Bohannon, Lauren, additional, Pittman, Alyssa, additional, Artica, Alexandra, additional, Ramalingam, Sendhilnathan, additional, Choi, Taewoong, additional, Gasparetto, Cristina, additional, Horwitz, Mitchell, additional, Long, Gwynn, additional, Lopez, Richard, additional, Rizzieri, David, additional, Sarantopoulos, Stefanie, additional, Sullivan, Keith, additional, Chao, Nelson, additional, and Sung, Anthony D., additional

Published
2021
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13. A phase 2 trial of the somatostatin analog pasireotide to prevent GI toxicity and acute GVHD in allogeneic hematopoietic stem cell transplant

Author

Ramalingam, Sendhilnathan, primary, Siamakpour-Reihani, Sharareh, additional, Bohannan, Lauren, additional, Ren, Yi, additional, Sibley, Alexander, additional, Sheng, Jeff, additional, Ma, Li, additional, Nixon, Andrew B., additional, Lyu, Jing, additional, Parker, Daniel C., additional, Bain, James, additional, Muehlbauer, Michael, additional, Ilkayeva, Olga, additional, Kraus, Virginia Byers, additional, Huebner, Janet L., additional, Spitzer, Thomas, additional, Brown, Jami, additional, Peled, Jonathan U., additional, van den Brink, Marcel, additional, Gomes, Antonio, additional, Choi, Taewoong, additional, Gasparetto, Cristina, additional, Horwitz, Mitchell, additional, Long, Gwynn, additional, Lopez, Richard, additional, Rizzieri, David, additional, Sarantopoulos, Stefanie, additional, Chao, Nelson, additional, and Sung, Anthony D., additional

Published
2021
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15. Sox9 expression marks a subset of CD24-expressing small intestine epithelial stem cells that form organoids in vitro

Author

Gracz, Adam D., Ramalingam, Sendhilnathan, and Magness, Scott T.

Subjects
Stem cells -- Research, Stem cells -- Genetic aspects, Stem cells -- Physiological aspects, Epithelium -- Physiological aspects, Epithelium -- Genetic aspects, Epithelium -- Research, Gene expression -- Physiological aspects, Gene expression -- Research, Biological sciences
Abstract

The inability to identify, isolate, and culture intestinal epithelial stem cells (IESCs) has been prohibitive to the study and therapeutic utilization of these cells. Using a [Sox9.sup.EGFP] mouse model, we demonstrate that [Sox9.sup.EGFP] fluorescence signatures can be used to differentiate between and enrich for progenitors ([Sox9.sup.EGFPsubLo]) and multipotent IESCs ([Sox9.sup.EGFPlo]). [Sox9.sup.EGFPlo] cells generate 'organoids' in a recently defined culture system that mimics the native IESC niche. These organoids possess all four differentiated cell types of the small intestine epithelium, demonstrating the multipotent capacity of [Sox9.sup.EGFPlo] cells. Our results are consistent with the previously reported observation that single IESCs generate cryptlike units without a detectable mesenchymal cell component. A prospective search revealed that CD24 is expressed in the [Sox9.sup.EGFPlo] population and marks IESCs that form organoids in culture. CD24 represents the first cell surface marker that facilitates fluorescence-activated cell sorting enrichment of IESCs with widely available antibodies without requiring a specialized fluorescent reporter gene mouse model. SOX factors; intestinal epithelial culture doi: 10.1152/ajpgi.00470.2009.

Published
2010

16. Pre-transplant hepatic steatosis (fatty liver) is associated with chronic graft-vs-host disease but not mortality

Author

Maung, Ko, primary, Ramalingam, Sendhilnathan, additional, Chaudhry, Mohammad, additional, Ren, Yi, additional, Jung, Sin-Ho, additional, Romero, Kristi, additional, Corbet, Kelly, additional, Chao, Nelson J., additional, Choi, Taewoong, additional, Diehl, Anna Mae, additional, Diehl, Louis, additional, Gasparetto, Cristina, additional, Horwitz, Mitchell, additional, Long, Gwynn Douglas, additional, Lopez, Richard D., additional, Rizzieri, David A., additional, Sarantopoulos, Stefanie, additional, Sullivan, Keith M., additional, Bashir, Mustafa R., additional, and Sung, Anthony D., additional

Published
2020
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18. Phase II Trial of Pasireotide to Prevent GI Toxicity and Acute Gvhd in Allogeneic HSCT

Author

Ramalingam, Sendhilnathan, primary, Siamakpour-Reihani, Sharareh, additional, Bohannon, Lauren, additional, Ren, Yi, additional, Sibley, Alexander, additional, Nixon, Andrew, additional, Lyu, Jing, additional, Xie, Jichun, additional, Choi, Taewoong, additional, Gasparetto, Cristina, additional, Horwitz, Mitchell E., additional, Long, Gwynn D., additional, Lopez, Richard, additional, Rizzieri, David A., additional, Sarantopoulos, Stefanie, additional, Chao, Nelson J., additional, and Sung, Anthony D., additional

Published
2020
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19. List of contributors

Author

Anderson, Matthew L., Beasley, Georgia M., Berchuck, Andrew, Brody, Jonathan R., Ciombor, Kristen K., Clarke, Jeffrey, Dave, Sandeep, Emmet, Matthew, Farrow, Norma E., Galal, Ahmed, Green, Michelle F., Gross, Jennifer H., Hari Ramalingam, Sendhilnathan, Harnden, Kathleen, Isaacs, James, Jia, Jingquan, Klempner, Samuel, M. Nanus, David, Madan, Ankit, Mauro, Lauren, McKinney, Matthew S., Mehta, Arnav, Montes de Oca, Mary Katherine, Odunsi, Kunle, Orlando, Lori A., Payne, Philip R.O., Pejovic, Tanja, Pennisi, Angela, Pishvaian, Michael J., Previs, Rebecca Ann, Reddy, Timothy E., Roth, Marc T., Shroff, Rachna, Spinosa, Daniel, Strickler, John H., Stubbs, Vanessa C., Therien, Aaron, Thomas, Giovana R., Tyler, Douglas S., Watson, Catherine H., Wu, R. Ryanne, and Zhu, Jason

Published
2022
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20. 106 - Assessing the Feasibility of a Novel mHealth App in Hematopoietic Stem Cell Transplant Patients

Author

Racioppi, Alessandro, Dalton, Tara, Ramalingam, Sendhilnathan, Romero, Kristi, Ren, Yi, Bohannon, Lauren, Arellano, Consuelo, Jonassaint, Jude, Miller, Hilary M., Barak, Ian, Fish, Laura J., Choi, Taewoong, Gasparetto, Cristina, Long, Gwynn D, Lopez, Richard D, Rizzieri, David A, Sarantopoulos, Stefanie, Horwitz, Mitchell E., Chao, Nelson J., Shah, Nirmish R, and Sung, Anthony

Published
2021
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22. Distinct Levels of Sox9 Expression Mark Colon Epithelial Stem Cells that Form Colonoids in Culture

Author

Ramalingam, Sendhilnathan

Subjects
embryonic structures
Abstract

Sox9 is an high-mobility group box transcription factor that is expressed in the stem cell zone of the small intestine and colon. We have previously used a Sox9EGFP mouse model to demonstrate that discrete levels of Sox9 expression mark small intestine epithelial stem cells that form crypt/villus-like structures in a three-dimensional culture system (Formeister EJ, Sionas AL, Lorance DK, Barkley CL, Lee GH, Magness ST. Am J Physiol Gastrointest Liver Physiol 296: G1108–G1118, 2009; Gracz AD, Ramalingam S, Magness ST. Am J Physiol Gastrointest Liver Physiol 298: G590–G600, 2010). In the present study, we hypothesized that discrete levels of Sox9 expression would also mark colonic epithelial stem cells (CESCs). Using the Sox9EGFP mouse model, we show that lower levels of Sox9 mark cells in the transit-amplifying progenitor cell zone, while higher levels of Sox9 mark cells in the colonic crypt base. Furthermore, we demonstrate that variable SOX9 levels persist in cells of colonic adenomas from mice and humans. Cells expressing lower Sox9 levels demonstrate gene expression profiles consistent with more differentiated populations, and cells expressing higher Sox9 levels are consistent with less differentiated populations. When placed in culture, cells expressing the highest levels of Sox9 formed “colonoids,” which are defined as bodies of cultured colonic epithelial cells that possess multiple cryptlike structures and a pseudolumen. Cells expressing the highest levels of Sox9 also demonstrate multipotency and self-renewal in vitro, indicating functional stemness. These data suggest a dose-dependent role for Sox9 in normal CESCs and cells comprising colon tumors. Furthermore, distinct Sox9 levels represent a new biomarker to study CESC and progenitor biology in physiological and disease states.

Published
2011
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25. Geriatric Assessment Reveals Actionable Impairments in Hematopoietic Stem Cell Transplant Candidates Ages 18-80 Years

Author

Lew, Meagan V., Ren, Yi, Lowder, Yen P., Siamakpour-Reihani, Sharareh, Ramalingam, Sendhilnathan, Romero, Kristi M., Thompson, Jillian C., Bohannon, Lauren M., McIntyre, Jackie, Tang, Helen, Van Opstal, Jolien, Cohen, Harvey Jay, Bartlett, David B., Pastva, Amy M., Morey, Miriam, Hall, Katherine S., Smith, Patrick, Peters, Katherine B., Somers, Tamara J., Kelleher, Sarah, Smith, Sophia K., Wischmeyer, Paul E., Lin, Pao-Hwa, Wood, William A., Thorpe, Glynnis, Minor, Kerry, Wiggins, Kristi, Hennig, Therese, Helms, Tanya, Welch, Renee, Matthews, Brittany, Liu, JoAnn, Burleson, Jill, Aberant, Thomas, Engemann, Ashley K., Henshall, Bethany, Darby, Maurisa, Proch, Christina, Dellascio, Michelle, Pittman, Alyssa, Suminguit, Jacob, Choi, Taewoong, Gasparetto, Cristina, Long, Gwynn D., Lopez, Richard D., Sarantopoulos, Stefanie, Horwitz, Mitchell E., Chao, Nelson J., and Sung, Anthony D.

Abstract

•Geriatric assessment can identify impairments in stem cell transplant candidates•Impairments can be found in older (>60 years) as well as younger (18-59) candidates•Identifying impairments can facilitate referrals and resolution of impairments•Geriatric assessment may help stem cell transplant candidates of all ages•KEY POINTS•Geriatric assessment can identify impairments in adult patients of all ages undergoing an allogeneic hematopoietic stem cell transplant.•Identification of impairments before transplant can facilitate referrals to supportive care and may improve transplant outcomes.

Published
2022
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27. Sequential Targeted Treatment for a Geriatric Patient with Acute Myeloid Leukemia with Concurrent FLT3-TKD and IDH1 Mutations.

Author

Chiang RS, Friedman DR, McHugh K, Ramalingam S, and Vashistha V

Abstract

Targeting and monitoring several acute myeloid leukemia mutations sequentially provides insights into optimal treatment plans., Competing Interests: Author disclosures The authors report no actual or potential conflicts of interest with regard to this article., (Copyright © 2021 Frontline Medical Communications Inc., Parsippany, NJ, USA.)

Published
2021
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