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3. Increased glucosylsphingosine levels and Gaucher disease in GBA1-associated Parkinson's disease

Author

Marano, Massimo, Zizzo, Carmela, Malaguti, Maria Chiara, Bacchin, Ruggero, Cavallieri, Francesco, De Micco, Rosa, Spagnolo, Francesca, Bentivoglio, Anna Rita, Schirinzi, Tommaso, Bovenzi, Roberta, Ramat, Silvia, Erro, Roberto, Sorrentino, Cristiano, Sucapane, Patrizia, Pilotto, Andrea, Lupini, Alessandro, Magliozzi, Alessandro, Di Vico, Ilaria, Carecchio, Miryam, Bonato, Giulia, Cilia, Roberto, Colucci, Fabiana, Tamma, Filippo, Caputo, Elena, Mostile, Giovanni, Arabia, Gennarina, Modugno, Nicola, Zibetti, Maurizio, Ceravolo, Maria Gabriella, Tambasco, Nicola, Cossu, Giovanni, Valzania, Franco, Manganotti, Paolo, Di Lazzaro, Vincenzo, Zappia, Mario, Fabbrini, Giovanni, Tinazzi, Michele, Tessitore, Alessandro, Duro, Giovanni, and Di Fonzo, Alessio

Published
2024
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7. Low-Frequency Activity in Dorsal Subthalamic Nucleus Predicts Impulsivity Improvement Following Deep Brain Stimulation in Parkinsonian Patients

Author

Kaymak, Ahmet, primary, Cubeddu, Laura, additional, Vissani, Matteo, additional, Taddeini, Fabio, additional, Caremani, Luca, additional, Govoni, Alessandra, additional, Micheli, Federico, additional, Valente, Simone, additional, Piattellini, Francesca, additional, Greco, Davide, additional, Pecchioli, Guido, additional, Ramat, Silvia, additional, and Mazzoni, Alberto, additional

Published
2024
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9. Comparing the effects of augmented virtual reality treadmill training versus conventional treadmill training in patients with stage II-III Parkinson’s disease: the VIRTREAD-PD randomized controlled trial protocol

Author

Lombardi, Gemma, primary, Baccini, Marco, additional, Gualerzi, Alice, additional, Pancani, Silvia, additional, Campagnini, Silvia, additional, Doronzio, Stefano, additional, Longo, Diego, additional, Maselli, Alessandro, additional, Cherubini, Giulio, additional, Piazzini, Michele, additional, Ciapetti, Tommaso, additional, Polito, Cristina, additional, Pinna, Samuele, additional, De Santis, Chiara, additional, Bedoni, Marzia, additional, Macchi, Claudio, additional, Ramat, Silvia, additional, and Cecchi, Francesca, additional

Published
2024
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11. Parkinson-ALS with a novel MAPT variant

Author

Ferrari, Camilla, primary, Ingannato, Assunta, additional, Matà, Sabrina, additional, Ramat, Silvia, additional, Caremani, Luca, additional, Bagnoli, Silvia, additional, Bessi, Valentina, additional, Sorbi, Sandro, additional, and Nacmias, Benedetta, additional

Published
2023
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13. The validity and reliability of the Italian Olfactory Identification Test (IOIT) in healthy subjects and in Parkinson's disease patients

Author

Maremmani, Carlo, Rossi, Giuseppe, Tambasco, Nicola, Fattori, Bruno, Pieroni, Aldo, Ramat, Silvia, Napolitano, Alessandro, Vanni, Paola, Serra, Palma, Piersanti, Patrizia, Zanetti, Michela, Coltelli, Maila, Orsini, Massimo, Marconi, Roberto, Purcaro, Carlo, Rossi, Aroldo, Calabresi, Paolo, and Meco, Giuseppe

Published
2012
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16. Validation of the Italian version of the Movement Disorder Society—Unified Parkinson’s Disease Rating Scale

Author

Antonini, Angelo, Abbruzzese, Giovanni, Ferini-Strambi, Luigi, Tilley, Barbara, Huang, Jing, Stebbins, Glenn T., Goetz, Christopher G., Barone, Paolo, Bandettini di Poggio, Monica, Fabbrini, Giovanni, Di Stasio, Flavio, Tinazzi, Michele, Bovi, Tommaso, Ramat, Silvia, Meoni, Sara, Pezzoli, Gianni, Canesi, Margherita, Martinelli, Paolo, Maria Scaglione, Cesa Lorella, Rossi, Aroldo, Tambasco, Nicola, Santangelo, Gabriella, Picillo, Marina, Morgante, Letterio, Morgante, Francesca, Quatrale, Rocco, Sensi, MariaChiara, Pilleri, Manuela, Biundo, Roberta, Nordera, Giampietro, Caria, Antonella, Pacchetti, Claudio, Zangaglia, Roberta, Lopiano, Leonardo, Zibetti, Maurizio, Zappia, Mario, Nicoletti, Alessandra, Quattrone, Aldo, Salsone, Maria, Cossu, Gianni, Murgia, Daniela, Albanese, Alberto, Del Sorbo, Francesca, and MDS-UPDRS Italian Validation Study Group

Published
2013
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17. The progression of non-motor symptoms in Parkinson’s disease and their contribution to motor disability and quality of life

Author

Antonini, Angelo, Barone, Paolo, Marconi, Roberto, Morgante, Letterio, Zappulla, Salvatore, Pontieri, Francesco Ernesto, Ramat, Silvia, Ceravolo, Maria Gabriella, Meco, Giuseppe, Cicarelli, Giulio, Pederzoli, Massimo, Manfredi, Michela, Ceravolo, Roberto, Mucchiut, Marco, Volpe, Giampiero, Abbruzzese, Giovanni, Bottacchi, Edo, Bartolomei, Luigi, Ciacci, Giuseppe, Cannas, Antonino, Randisi, Maria Giovanna, Petrone, Alfredo, Baratti, Mario, Toni, Vincenzo, Cossu, Giovanni, Del Dotto, Paolo, Bentivoglio, Anna Rita, Abrignani, Michele, Scala, Rossana, Pennisi, Franco, Quatrale, Rocco, Gaglio, Rosa Maria, Nicoletti, Alessandra, Perini, Michele, Avarello, Tania, Pisani, Antonio, Scaglioni, Augusto, Martinelli, Paolo Emilio, Iemolo, Francesco, Ferigo, Laura, Simone, Pasqualino, Soliveri, Paola, Troianiello, Biagio, Consoli, Domenico, Mauro, Alessandro, Lopiano, Leonardo, Nastasi, Giuseppe, and Colosimo, Carlo

Published
2012
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18. Frontal assessment battery scores and non-motor symptoms in parkinsonian disorders

Author

Marconi, Roberto, Antonini, Angelo, Barone, Paolo, Colosimo, Carlo, Avarello, Tania P., Bottacchi, Edo, Cannas, Antonino, Ceravolo, Maria G., Ceravolo, Roberto, Cicarelli, Giulio, Gaglio, Rosa M., Giglia, Luisa, Iemolo, Francesco, Manfredi, Michela, Meco, Giuseppe, Nicoletti, Alessandra, Pederzoli, Massimo, Petrone, Alfredo, Pisani, Antonio, Pontieri, Francesco E., Quatrale, Rocco, Ramat, Silvia, Scala, Rossana, Volpe, Giampiero, Zappulla, Salvatore, Bentivoglio, Anna Rita, Stocchi, Fabrizio, Trianni, Giorgio, Del Dotto, Paolo, De Gaspari, Danilo, Grasso, Lucia, Morgante, Francesca, Santangelo, Gabriella, Fabbrini, Giovanni, and Morgante, Letterio

Published
2012
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21. Non-motor symptoms in atypical and secondary parkinsonism: the PRIAMO study

Author

Colosimo, Carlo, Morgante, Letterio, Antonini, Angelo, Barone, Paolo, Avarello, Tania P., Bottacchi, Edo, Cannas, Antonino, Ceravolo, Maria Gabriella, Ceravolo, Roberto, Cicarelli, Giulio, Gaglio, Rosa M., Giglia, Luisa, Iemolo, Francesco, Manfredi, Michela, Meco, Giuseppe, Nicoletti, Alessandra, Pederzoli, Massimo, Petrone, Alfredo, Pisani, Antonio, Pontieri, Francesco E., Quatrale, Rocco, Ramat, Silvia, Scala, Rossana, Volpe, Giampiero, Zappulla, Salvatore, Bentivoglio, Anna Rita, Stocchi, Fabrizio, Trianni, Giorgio, Del Dotto, Paolo, Simoni, Lucia, Marconi, Roberto, and and PRIAMO STUDY GROUP

Published
2010
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25. Psychosis associated to Parkinsonʼs disease in the early stages: relevance of cognitive decline and depression

Author

Morgante, Letterio, Colosimo, Carlo, Antonini, Angelo, Marconi, Roberto, Meco, Giuseppe, Pederzoli, Massimo, Pontieri, Francesco E, Cicarelli, Giulio, Abbruzzese, Giovanni, Zappulla, Salvatore, Ramat, Silvia, Manfredi, Michela, Bottacchi, Edo, Abrignani, Michele, Berardelli, Alfredo, Cozzolino, Autilia, Paradiso, Claudio, De Gaspari, Danilo, Morgante, Francesca, and Barone, Paolo

Published
2012
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27. The PRIAMO study: A multicenter assessment of nonmotor symptoms and their impact on quality of life in Parkinsonʼs disease

Author

Barone, Paolo, Antonini, Angelo, Colosimo, Carlo, Marconi, Roberto, Morgante, Letterio, Avarello, Tania P., Bottacchi, Eugenio, Cannas, Antonino, Ceravolo, Gabriella, Ceravolo, Roberto, Cicarelli, Giulio, Gaglio, Roberto M., Giglia, Rosa M., Iemolo, Francesco, Manfredi, Michela, Meco, Giuseppe, Nicoletti, Alessandra, Pederzoli, Massimo, Petrone, Alfredo, Pisani, Antonio, Pontieri, Francesco E., Quatrale, Rocco, Ramat, Silvia, Scala, Rosanna, Volpe, Giuseppe, Zappulla, Salvatore, Bentivoglio, Anna Rita, Stocchi, Fabrizio, Trianni, Giorgio, and Dotto, Paolo Del

Published
2009
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29. Exploring causality of the association between smoking and Parkinson's disease

Author

Gallo, Valentina, Vineis, Paolo, Cancellieri, Mariagrazia, Chiodini, Paolo, Barker, Roger A., Brayne, Carol, Pearce, Neil, Vermeulen, Roel, Panico, Salvatore, Bueno-de-Mesquita, Bas, Vanacore, Nicola, Forsgren, Lars, Ramat, Silvia, Ardanaz, Eva, Arriola, Larraitz, Peterson, Jesper, Hansson, Oskar, Gavrila, Diana, Sacerdote, Carlotta, Sieri, Sabina, Kühn, Tilman, Katzke, Verena A., van der Schouw, Yvonne T., Kyrozis, Andreas, Masala, Giovanna, Mattiello, Amalia, Perneczky, Robert, Middleton, Lefkos, Saracci, Rodolfo, Riboli, Elio, Gallo, Valentina, Vineis, Paolo, Cancellieri, Mariagrazia, Chiodini, Paolo, Barker, Roger A., Brayne, Carol, Pearce, Neil, Vermeulen, Roel, Panico, Salvatore, Bueno-de-Mesquita, Bas, Vanacore, Nicola, Forsgren, Lars, Ramat, Silvia, Ardanaz, Eva, Arriola, Larraitz, Peterson, Jesper, Hansson, Oskar, Gavrila, Diana, Sacerdote, Carlotta, Sieri, Sabina, Kühn, Tilman, Katzke, Verena A., van der Schouw, Yvonne T., Kyrozis, Andreas, Masala, Giovanna, Mattiello, Amalia, Perneczky, Robert, Middleton, Lefkos, Saracci, Rodolfo, and Riboli, Elio

Abstract

Background: The aim of this paper is to investigate the causality of the inverse association between cigarette smoking and Parkinson's disease (PD). The main suggested alternatives include a delaying effect of smoking, reverse causality or an unmeasured confounding related to a low-risk-taking personality trait. Methods: A total of 715 incident PD cases were ascertained in a cohort of 220 494 individuals from NeuroEPIC4PD, a prospective European population-based cohort study including 13 centres in eight countries. Smoking habits were recorded at recruitment. We analysed smoking status, duration, and intensity and exposure to passive smoking in relation to PD onset. Results: Former smokers had a 20% decreased risk and current smokers a halved risk of developing PD compared with never smokers. Strong dose-response relationships with smoking intensity and duration were found. Hazard ratios (HRs) for smoking <20 years were 0.84 [95% confidence interval (CI) 0.67-1.07], 20-29 years 0.73 (95% CI 0.56-0.96) and >30 years 0.54 (95% CI 0.43-0.36) compared with never smokers. The proportional hazard assumption was verified, showing no change of risk over time, arguing against a delaying effect. Reverse causality was disproved by the consistency of dose-response relationships among former and current smokers. The inverse association between passive smoking and PD, HR 0.70 (95% CI 0.49-0.99) ruled out the effect of unmeasured confounding. Conclusions: These results are highly suggestive of a true causal link between smoking and PD, although it is not clear which is the chemical compound in cigarette smoking responsible for the biological effect.

Published
2019
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30. Exploring causality of the association between smoking and Parkinson's disease

Author

UMC Utrecht, Public Health Practice, MS MDL 1, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Circulatory Health, Cardiovasculaire Epidemiologie, Gallo, Valentina, Vineis, Paolo, Cancellieri, Mariagrazia, Chiodini, Paolo, Barker, Roger A., Brayne, Carol, Pearce, Neil, Vermeulen, Roel, Panico, Salvatore, Bueno-de-Mesquita, Bas, Vanacore, Nicola, Forsgren, Lars, Ramat, Silvia, Ardanaz, Eva, Arriola, Larraitz, Peterson, Jesper, Hansson, Oskar, Gavrila, Diana, Sacerdote, Carlotta, Sieri, Sabina, Kühn, Tilman, Katzke, Verena A., van der Schouw, Yvonne T., Kyrozis, Andreas, Masala, Giovanna, Mattiello, Amalia, Perneczky, Robert, Middleton, Lefkos, Saracci, Rodolfo, Riboli, Elio, UMC Utrecht, Public Health Practice, MS MDL 1, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Circulatory Health, Cardiovasculaire Epidemiologie, Gallo, Valentina, Vineis, Paolo, Cancellieri, Mariagrazia, Chiodini, Paolo, Barker, Roger A., Brayne, Carol, Pearce, Neil, Vermeulen, Roel, Panico, Salvatore, Bueno-de-Mesquita, Bas, Vanacore, Nicola, Forsgren, Lars, Ramat, Silvia, Ardanaz, Eva, Arriola, Larraitz, Peterson, Jesper, Hansson, Oskar, Gavrila, Diana, Sacerdote, Carlotta, Sieri, Sabina, Kühn, Tilman, Katzke, Verena A., van der Schouw, Yvonne T., Kyrozis, Andreas, Masala, Giovanna, Mattiello, Amalia, Perneczky, Robert, Middleton, Lefkos, Saracci, Rodolfo, and Riboli, Elio

Published
2019

35. Prevalence and impact of COVID-19 in Parkinson's disease: evidence from a multi-center survey in Tuscany region.

Author

Del Prete, Eleonora, Francesconi, Alessio, Palermo, Giovanni, Mazzucchi, Sonia, Frosini, Daniela, Morganti, Riccardo, Coleschi, Piero, Raglione, Laura Maria, Vanni, Paola, Ramat, Silvia, Novelli, Alessio, Napolitano, Alessandro, Battisti, Carla, Giuntini, Martina, Rossi, Carlo, Menichetti, Chiara, Ulivelli, Monica, De Franco, Valentino, Rossi, Simone, and Bonuccelli, Ubaldo

Subjects
COVID-19, PARKINSON'S disease, DISEASE risk factors, SYMPTOMS
Abstract

Background: If Parkinson's Disease (PD) may represent a risk factor for Coronavirus disease 2019 (COVID-19) is debated and there are few data on the direct and indirect effects of this pandemic in PD patients. Objective: In the current study we evaluated the prevalence, mortality and case-fatality of COVID-19 in a PD cohort, also exploring possible risk factors. We also aimed to investigate the effect of lockdown on motor/non-motor symptoms in PD patients as well as their acceptability/accessibility to telemedicine. Method: A case-controlled survey about COVID-19 and other clinical features in PD patients living in Tuscany was conducted. In non-COVID-19 PD patients motor/non-motor symptoms subjective worsening during the lockdown as well as feasibility of telemedicine were explored. Results: Out of 740 PD patients interviewed, 7 (0.9%) were affected by COVID-19, with 0.13% mortality and 14% case-fatality. COVID-19 PD patients presented a higher presence of hypertension (p < 0.001) and diabetes (p = 0.049) compared to non-COVID-19. In non-COVID-19 PD population (n = 733) about 70% did not experience a subjective worsening of motor symptoms or mood, anxiety or insomnia. In our population 75.2% of patients was favorable to use technology to perform scheduled visits, however facilities for telemedicine were available only for 51.2% of cases. Conclusion: A higher prevalence of COVID-19 respect to prevalence in Tuscany and Italy was found in the PD population. Hypertension and diabetes, as for general population, were identified as risk factors for COVID-19 in PD. PD patients did not experience a subjective worsening of symptoms during lockdown period and they were also favorable to telemedicine, albeit we reported a reduced availability to perform it. [ABSTRACT FROM AUTHOR]

Published
2021
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36. Exploring causality of the association between smoking and Parkinson’s disease

Author

Gallo, Valentina, Vineis, Paolo, Cancellieri, Mariagrazia, Chiodini, Paolo, Barker, Roger A, Brayne, Carol, Pearce, Neil, Vermeulen, Roel, Panico, Salvatore, Bueno-de-Mesquita, Bas, Vanacore, Nicola, Forsgren, Lars, Ramat, Silvia, Ardanaz, Eva, Arriola, Larraitz, Peterson, Jesper, Hansson, Oskar, Gavrila, Diana, Sacerdote, Carlotta, Sieri, Sabina, Kühn, Tilman, Katzke, Verena A, van der Schouw, Yvonne T, Kyrozis, Andreas, Masala, Giovanna, Mattiello, Amalia, Perneczky, Robert, Middleton, Lefkos, Saracci, Rodolfo, Riboli, Elio, Gallo, Valentina, Vineis, Paolo, Cancellieri, Mariagrazia, Chiodini, Paolo, Barker, Roger A, Brayne, Carol, Pearce, Neil, Vermeulen, Roel, Panico, Salvatore, Bueno-de-Mesquita, Bas, Vanacore, Nicola, Forsgren, Lars, Ramat, Silvia, Ardanaz, Eva, Arriola, Larraitz, Peterson, Jesper, Hansson, Oskar, Gavrila, Diana, Sacerdote, Carlotta, Sieri, Sabina, Kühn, Tilman, Katzke, Verena A, van der Schouw, Yvonne T, Kyrozis, Andreas, Masala, Giovanna, Mattiello, Amalia, Perneczky, Robert, Middleton, Lefkos, Saracci, Rodolfo, and Riboli, Elio

Abstract

Background: The aim of this paper is to investigate the causality of the inverse association between cigarette smoking and Parkinson's disease (PD). The main suggested alternatives include a delaying effect of smoking, reverse causality or an unmeasured confounding related to a low-risk-taking personality trait. Methods: A total of 715 incident PD cases were ascertained in a cohort of 220 494 individuals from NeuroEPIC4PD, a prospective European population-based cohort study including 13 centres in eight countries. Smoking habits were recorded at recruitment. We analysed smoking status, duration, and intensity and exposure to passive smoking in relation to PD onset. Results: Former smokers had a 20% decreased risk and current smokers a halved risk of developing PD compared with never smokers. Strong dose-response relationships with smoking intensity and duration were found. Hazard ratios (HRs) for smoking 30 years 0.54 (95% CI 0.43-0.36) compared with never smokers. The proportional hazard assumption was verified, showing no change of risk over time, arguing against a delaying effect. Reverse causality was disproved by the consistency of dose-response relationships among former and current smokers. The inverse association between passive smoking and PD, HR 0.70 (95% CI 0.49-0.99) ruled out the effect of unmeasured confounding. Conclusions: These results are highly suggestive of a true causal link between smoking and PD, although it is not clear which is the chemical compound in cigarette smoking responsible for the biological effect.

Published
2018

37. Exploring causality of the association between smoking and Parkinson’s disease

Author

One Health Chemisch, dIRAS RA-2, Gallo, Valentina, Vineis, Paolo, Cancellieri, Mariagrazia, Chiodini, Paolo, Barker, Roger A, Brayne, Carol, Pearce, Neil, Vermeulen, Roel, Panico, Salvatore, Bueno-de-Mesquita, Bas, Vanacore, Nicola, Forsgren, Lars, Ramat, Silvia, Ardanaz, Eva, Arriola, Larraitz, Peterson, Jesper, Hansson, Oskar, Gavrila, Diana, Sacerdote, Carlotta, Sieri, Sabina, Kühn, Tilman, Katzke, Verena A, van der Schouw, Yvonne T, Kyrozis, Andreas, Masala, Giovanna, Mattiello, Amalia, Perneczky, Robert, Middleton, Lefkos, Saracci, Rodolfo, Riboli, Elio, One Health Chemisch, dIRAS RA-2, Gallo, Valentina, Vineis, Paolo, Cancellieri, Mariagrazia, Chiodini, Paolo, Barker, Roger A, Brayne, Carol, Pearce, Neil, Vermeulen, Roel, Panico, Salvatore, Bueno-de-Mesquita, Bas, Vanacore, Nicola, Forsgren, Lars, Ramat, Silvia, Ardanaz, Eva, Arriola, Larraitz, Peterson, Jesper, Hansson, Oskar, Gavrila, Diana, Sacerdote, Carlotta, Sieri, Sabina, Kühn, Tilman, Katzke, Verena A, van der Schouw, Yvonne T, Kyrozis, Andreas, Masala, Giovanna, Mattiello, Amalia, Perneczky, Robert, Middleton, Lefkos, Saracci, Rodolfo, and Riboli, Elio

Published
2018

38. Parkinson's Disease Case Ascertainment in the EPIC Cohort: The NeuroEPIC4PD Study

Author

Gallo, Valentina, Brayne, Carol, Forsgren, Lars, Barker, Roger A, Petersson, Jesper, Hansson, Oskar, Lindqvist, Daniel, Ruffmann, Claudio, Ishihara, Lianna, Luben, Robert, Arriola, Larraitz, Bergareche, Alberto, Gavrila, Diana, Erro, Maria Elena, Vanacore, Nicola, Sacerdote, Carlotta, Bueno-de-Mesquita, Bas, Vermeulen, Roel, Seelen, Meinie, Sieri, Sabina, Masala, Giovanna, Ramat, Silvia, Kyrozis, Andreas, Thricopolou, Antonia, Panico, Salvatore, Mattiello, Amalia, Kaaks, Rudolf, Teucher, Birgit, Katzke, Verena, Kloss, Manja, Curry, Lisa, Calboli, Federico, Riboli, Elio, Vineis, Paolo, Middleton, Lefkos, dIRAS RA-I&I RA, Risk Assessment, Infection & Immunity, LS IRAS EEPI GRA (Gezh.risico-analyse), Gallo, Valentina, Brayne, Carol, Forsgren, Lar, Barker, Roger A, Petersson, Jesper, Hansson, Oskar, Lindqvist, Daniel, Ruffmann, Claudio, Ishihara, Lianna, Luben, Robert, Arriola, Larraitz, Bergareche, Alberto, Gavrila, Diana, Erro, Maria Elena, Vanacore, Nicola, Sacerdote, Carlotta, Bueno de Mesquita, Ba, Vermeulen, Roel, Seelen, Meinie, Sieri, Sabina, Masala, Giovanna, Ramat, Silvia, Kyrozis, Andrea, Thricopolou, Antonia, Panico, Salvatore, Mattiello, Amalia, Kaaks, Rudolf, Teucher, Birgit, Katzke, Verena, Kloss, Manja, Curry, Lisa, Calboli, Federico, Riboli, Elio, Vineis, Paolo, Middleton, Lefkos, dIRAS RA-I&I RA, Risk Assessment, Infection & Immunity, and LS IRAS EEPI GRA (Gezh.risico-analyse)

Subjects
Gerontology, Adult, Male, medicine.medical_specialty, Neurology, Parkinson's disease, Disease, Hypokinesia, Record linkage, Age Distribution, Risk Factors, Epidemiology, Validation, medicine, Humans, Prospective Studies, Prospective cohort study, Exercise, Aged, Aged, 80 and over, business.industry, Incidence, Case ascertainment, Parkinson Disease, Middle Aged, medicine.disease, EPIC study, Prospective Studie, Cohort, Parkinson’s disease, Female, Neurology (clinical), business, Cohort study, Human
Abstract

Background/Aims: Large epidemiological prospective studies represent an important opportunity for investigating risk factors for rare diseases such as Parkinson's disease (PD). Here we describe the procedures we used for ascertaining PD cases in the EPIC (European Prospective Investigation into Cancer and Nutrition) study. Methods: The following three-phase procedure was used: (1) elaboration of a NeuroEPIC4PD template for clinical data collection, (2) identification of all potential PD cases via record linkage and (3) validation of the diagnosis through clinical record revision, in a population of 220,494 subjects recruited in 7 European countries. All cases were labelled with the NeuroEPIC4PD diagnoses of ‘definite', ‘very likely', ‘probable', or ‘possible' PD. Results: A total of 881 PD cases were identified, with over 2,741,780 person-years of follow-up (199 definite, 275 very likely, 146 probable, and 261 possible). Of these, 734 were incident cases. The mean age at diagnosis was 67.9 years (SD 9.2) and 458 patients (52.0%) were men. Bradykinesia was the most frequent presenting motor sign (76.5%). Tremor-dominant and akinetic rigid forms of PD were the most common types of PD. A total of 289 patients (32.8%) were dead at the time of the last follow-up. Conclusions: This exercise proved that it is feasible to ascertain PD in large population-based cohort studies and offers a potential framework to be replicated in similar studies.

Published
2015

39. Impulse control disorders in Parkinson's disease versus in healthy controls: A different predictive model.

Author

Izzo, Viola Angela, Donati, Maria Anna, Torre, Elena, Ramat, Silvia, and Primi, Caterina

Subjects
IMPULSE control disorders, PARKINSON'S disease, PREDICTION models, FOOD habits, COMPULSIVE gambling
Abstract

Impulse control disorders (ICDs), including compulsive gambling, buying, sexual behaviour and eating, are not only a severe disorder that can affect the general, non‐clinical population, but also a serious, increasingly recognized psychiatric complication in Parkinson's disease (PD). Previous research detected some risk factors for their occurrence in PD patients and in the general population, including impulsivity. However, impulsivity is a multidimensional construct that comprises several aspects, including reflection impulsivity and delay discounting. The present work assessed different facets of impulsivity in both PD patients and in the healthy controls (HCs) to examine whether they scored differently, and if the occurrence of ICDs in PD patients and in the HCs was predicted by different aspects of impulsivity. The results showed that ICDs in PD patients were predicted by a strong preference for immediate rewards, whereas ICDs in the HCs were predicted by a deficient reflective ability. The present findings may help clinicians in the early identification of PD patients who could develop ICDs by simply assessing their impulsivity in terms of delay discounting. Furthermore, this work contributed to identify another risk factor for ICDs in the non‐clinical population. [ABSTRACT FROM AUTHOR]

Published
2020
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40. Exploring causality of the association between smoking and Parkinson’s disease

Author

Gallo, Valentina, primary, Vineis, Paolo, additional, Cancellieri, Mariagrazia, additional, Chiodini, Paolo, additional, Barker, Roger A, additional, Brayne, Carol, additional, Pearce, Neil, additional, Vermeulen, Roel, additional, Panico, Salvatore, additional, Bueno-de-Mesquita, Bas, additional, Vanacore, Nicola, additional, Forsgren, Lars, additional, Ramat, Silvia, additional, Ardanaz, Eva, additional, Arriola, Larraitz, additional, Peterson, Jesper, additional, Hansson, Oskar, additional, Gavrila, Diana, additional, Sacerdote, Carlotta, additional, Sieri, Sabina, additional, Kühn, Tilman, additional, Katzke, Verena A, additional, van der Schouw, Yvonne T, additional, Kyrozis, Andreas, additional, Masala, Giovanna, additional, Mattiello, Amalia, additional, Perneczky, Robert, additional, Middleton, Lefkos, additional, Saracci, Rodolfo, additional, and Riboli, Elio, additional

Published
2018
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41. Are there adaptive changes in the human brain of patients with Parkinson’s disease treated with long-term deep brain stimulation of the subthalamic nucleus? A 4-year follow-up study with regional cerebral blood flow SPECT

Author

Alberto Pupi, Sandro Sorbi, Antonio Castagnoli, Franco Ammannati, Stelvio Sestini, and Ramat Silvia

Subjects
Male, Parkinson's disease, Deep brain stimulation, Deep Brain Stimulation, medicine.medical_treatment, Adaptive change, Subthalamic Nucleus, medicine, Humans, Radiology, Nuclear Medicine and imaging, In patient, Tomography, Emission-Computed, Single-Photon, Brain Mapping, business.industry, Follow up studies, Parkinson Disease, General Medicine, Human brain, Middle Aged, medicine.disease, Adaptation, Physiological, nervous system diseases, Subthalamic nucleus, Treatment Outcome, surgical procedures, operative, medicine.anatomical_structure, nervous system, Cerebral blood flow, Cerebrovascular Circulation, Anesthesia, Female, business, therapeutics, Follow-Up Studies
Abstract

The aim of this follow-up study was to assess persistent motor and regional cerebral blood flow (rCBF) changes in patients with Parkinson's disease (PD) treated with high-frequency deep brain stimulation (DBS) of the subthalamic nucleus (STN).Ten PD patients with STN-DBS underwent three rCBF SPECT studies at rest, once preoperatively in the off-drug condition (T(0)), and twice postoperatively in the off-drug/off-stimulation conditions at 5 +/- 2 (T(1)) and 42 +/- 7 months (T(2)). Patients were assessed using the UPDRS, HY and SE scales. SPM was used to investigate baseline rCBF changes from the preoperative condition to the postoperative conditions and the relationship between rCBF and UPDRS scores used as covariate of interest.Parkinsonian patients showed a clinical improvement which was significant only on follow-up at 42 months. The main effect of treatment from T(0) to T(1) was to produce baseline rCBF increases in the pre-supplementary motor area (pre-SMA), premotor cortex and somatosensory association cortex. From T(1) to T(2) a further baseline rCBF increase was detected in the pre-SMA (p0.0001). A correlation was detected between the slight improvement in motor scores and the rCBF increase in the pre-SMA (p0.0001), which is known to play a crucial role in clinical progression.Our study suggests the presence of adaptive functional changes in the human brain of PD patients treated with long-term STN-DBS. Such adaptive processes seem to occur in the pre-SMA and to play only a slightly beneficial role in terms of functional compensation of motor impairment.

Published
2007

42. Psychosis associated to Parkinson's disease in the early stages: Relevance of cognitive decline and depression

Author

Ceravolo, Roberto, Morgante, Letterio, Colosimo, Carlo, Antonini, Angelo, Marconi, Roberto, Meco, Giuseppe, Pederzoli, Massimo, Pontieri, Francesco E., Cicarelli, Giulio, Abbruzzese, Giovanni, Zappulla, Salvatore, Ramat, Silvia, Manfredi, Michela, Bottacchi, Edo, Abrignani, Michele, Berardelli, Alfredo, Cozzolino, Autilia, Paradiso, Claudio, De Gaspari, Danilo, Morgante, Francesca, and Barone, Paolo

Subjects
Male, Pediatrics, medicine.medical_specialty, Psychosis, Parkinson's disease, Hallucinations, Disease, Severity of Illness Index, Statistics, Nonparametric, Cognition, Arts and Humanities (miscellaneous), Risk Factors, Severity of illness, Prevalence, medicine, Humans, Nonparametric, Longitudinal Studies, Cognitive decline, Psychiatry, Depression (differential diagnoses), Aged, Psychiatric Status Rating Scales, Chi-Square Distribution, Depression, Incidence, Parkinsonism, Statistics, Female, Logistic Models, Middle Aged, Parkinson Disease, Psychotic Disorders, Neurology (clinical), Psychiatry and Mental Health, Surgery, medicine.disease, Psychiatry and Mental health, Anxiety, medicine.symptom, Psychology
Abstract

Objective To evaluate the prevalence of psychosis associated with Parkinson9s disease (PSY-PD) in its early stages, its incidence over a 24 month follow-up period and the association with motor and non-motor clinical features. Methods PRIAMO is a 2 year longitudinal observational study that has enrolled patients with parkinsonism in 55 Italian centres. A cohort of 495 patients with early disease stage PD (baseline Hoehn and Yahr score ≤2, disease9s duration (median) 3.4 years) were followed for 2 years. PSY-PD was evaluated by means of a clinician rated questionnaire and defined as the presence of at least one of the following symptoms occurring for at least 1 month: illusions, hallucinations, jealousy ideas and persecutory ideas. Patients with and without PSY-PD were compared on several clinical variables, encompassing motor and non-motor features. Results The prevalence of PSY-PD at baseline was 3%; the incidences at 12 and 24 months were 5.2% and 7.7%, respectively. Longer disease duration and prescription of dopamine agonists at baseline were associated with the development of PSY-PD over the 24 month period. At this follow-up time, worse disease severity, decline in cognitive performances, presence of depressive symptoms and anxiety were more frequently observed in PSY-PD. Conclusions Psychotic type symptoms may occur in the early stages of PD although less frequently than in later stages. Beyond dopaminergic treatment, there are disease related factors, such as disease severity and the occurrence of cognitive and depressive symptoms, which may underlie the onset of psychotic type symptoms from the earliest stages.

Published
2012

46. Frontal assessment battery scores and non-motor symptoms in parkinsonian disorders

Author

Marconi, Roberto, primary, Antonini, Angelo, additional, Barone, Paolo, additional, Colosimo, Carlo, additional, Avarello, Tania P., additional, Bottacchi, Edo, additional, Cannas, Antonino, additional, Ceravolo, Maria G., additional, Ceravolo, Roberto, additional, Cicarelli, Giulio, additional, Gaglio, Rosa M., additional, Giglia, Luisa, additional, Iemolo, Francesco, additional, Manfredi, Michela, additional, Meco, Giuseppe, additional, Nicoletti, Alessandra, additional, Pederzoli, Massimo, additional, Petrone, Alfredo, additional, Pisani, Antonio, additional, Pontieri, Francesco E., additional, Quatrale, Rocco, additional, Ramat, Silvia, additional, Scala, Rossana, additional, Volpe, Giampiero, additional, Zappulla, Salvatore, additional, Bentivoglio, Anna Rita, additional, Stocchi, Fabrizio, additional, Trianni, Giorgio, additional, Del Dotto, Paolo, additional, De Gaspari, Danilo, additional, Grasso, Lucia, additional, Morgante, Francesca, additional, Santangelo, Gabriella, additional, Fabbrini, Giovanni, additional, and Morgante, Letterio, additional

Published
2011
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48. Brain metabolic correlates of dopaminergic degeneration in de novo idiopathic Parkinson’s disease

Author

Berti, Valentina, primary, Polito, Cristina, additional, Ramat, Silvia, additional, Vanzi, Eleonora, additional, De Cristofaro, Maria Teresa, additional, Pellicanò, Giannantonio, additional, Mungai, Francesco, additional, Marini, Paolo, additional, Formiconi, Andreas Robert, additional, Sorbi, Sandro, additional, and Pupi, Alberto, additional

Published
2009
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50. Daytime course of sleepiness in de novo Parkinson's disease patients.

Author

Giganti, Fiorenza, Ramat, Silvia, Zilli, Iole, Guidi, Sara, Raglione, Laura Maria, Sorbi, Sandro, and Salzarulo, Piero

Subjects
*DROWSINESS, *PARKINSON'S disease patients, *SLEEP-wake cycle, *SOMNOLOGY, *NEUROSCIENCES
Abstract

Normal subjects show an increase of sleepiness in the morning, early afternoon and before sleep. In the advanced stages of Parkinson's disease ( PD) the mean level of sleepiness is quite high, while with respect to healthy subjects it seems to be unchanged in the early stages. The aim of this study was to evaluate the time-course of the sleepiness level during the wakefulness period in untreated patients with early-stage Parkinson's disease. Eighteen Parkinson's disease patients who had never been treated before with dopaminergic drugs (male = 9, female = 9, age: 68.39 ± 1.89, mean ± standard error) and 18 healthy subjects (male = 9, female = 9, age: 67.22 ± 1.98) were recruited for this study. All subjects underwent continuous actigraphic recording for three consecutive days, during which they also completed the Karolinska Sleepiness Scale ( KSS) once an hour throughout wakefulness. Our results showed a higher level of sleepiness in the patients than the controls in the hours following awakening and in the early afternoon, specifically at 08:00 and 14:00 hours (08:00 hours, PD patients, KSS: 3 ± 0.3 versus healthy subjects, KSS: 2 ± 0.2, P < 0.05; 14:00 hours, PD patients, KSS: 4.4 ± 0.5 versus healthy subjects, KSS: 3 ± 0.3, P < 0.05). We suggest that some daytime hours are sensitive windows showing the first increase of sleepiness which will spread later to the whole daytime. [ABSTRACT FROM AUTHOR]

Published
2013
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