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1. Satisfactory outcomes following a second autologous hematopoietic cell transplantation for multiple myeloma in poor stem cell mobilizers: a retrospective study on behalf of the Chronic Malignancies Working Party of the EBMT

Author

Sever, Matjaz, Drozd-Sokolowska, Joanna, Gras, Luuk, Koster, Linda, Folber, Frantisek, Mielke, Stephan, Fenk, Roland, Basak, Grzegorz, Apperley, Jane, Byrne, Jennifer, Rambaldi, Alessandro, Ringhoffer, Mark, Eder, Matthias, Trneny, Marek, Blaise, Didier, Lenhoff, Stig, Isaksson, Cecilia, Passweg, Jakob, Partanen, Anu, Sakellari, Ioanna, Schönland, Stefan, Morris, Curly, Beksac, Meral, Raj, Kavita, Hayden, Patrick J., and McLornan, Donal P.

Published
2024
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2. Trends in allogeneic transplantation for favorable risk acute myeloid leukemia in first remission: a longitudinal study of >15 years from the ALWP of the EBMT

Author

Nagler, Arnon, Labopin, Myriam, Salmenniemi, Urpu, Wu, Depei, Blaise, Didier, Rambaldi, Alessandro, Reményi, Péter, Forcade, Edouard, Socié, Gérard, Chevallier, Patrice, von dem Borne, Peter, Burns, David, Schmid, Christoph, Maertens, Johan, Kröger, Nicolaus, Bug, Gesine, Aljurf, Mahmoud, Vydra, Jan, Halaburda, Kazimierz, Ciceri, Fabio, and Mohty, Mohamad

Published
2024
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3. Prognostic factors impacting post-transplant outcomes in adult T-cell acute lymphoblastic leukemia: a registry-based study by the EBMT acute leukemia working party

Author

El Cheikh, Jean, Ngoya, Maud, Galimard, Jacques-Emmanuel, Reményi, Péter, Kulagin, Alexander, Aljurf, Mahmoud, Mousavi, Ashrafsadat, Wu, Depei, Ozcelik, Tulay, Salmenniemi, Urpu, Castilla-Llorente, Cristina, Socie, Gerard, Helbig, Grzegorz, Schroeder, Thomas, Sakellari, Ioanna, Rambaldi, Alessandro, Burt, Richard, Busca, Alessandro, Balsat, Marie, Stelljes, Matthias, Brissot, Eolia, Giebel, Sebastien, Peric, Zinaida, Nagler, Arnon, Bazarbachi, Ali, Ciceri, Fabio, and Mohty, Mohamad

Published
2024
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4. Safety and efficacy of narsoplimab in pediatric and adult patients with transplant-associated thrombotic microangiopathy: a real-world experience

Author

Castelli, Marta, Micò, Maria Caterina, Grassi, Anna, Algarotti, Alessandra, Lussana, Federico, Finazzi, Maria Chiara, Rambaldi, Benedetta, Pavoni, Chiara, Rizzuto, Giuliana, Tebaldi, Paola, Vendemini, Francesca, Verna, Marta, Bonanomi, Sonia, Biondi, Andrea, Balduzzi, Adriana, Rambaldi, Alessandro, and Gotti, Giacomo

Published
2024
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5. Allogeneic hematopoietic stem-cell transplantation for patients with Richter transformation: a retrospective study on behalf of the Chronic Malignancies Working Party of the EBMT

Author

Guièze, Romain, Eikema, Diderik-Jan, Koster, Linda, Schetelig, Johannes, Sengeloev, Henrik, Passweg, Jakob, Finke, Jürgen, Arat, Mutlu, Broers, Annoek E. C., Stölzel, Friedrich, Byrne, Jenny, Castilla-Llorente, Cristina, Dreger, Peter, Eder, Matthias, Gedde-Dahl, Tobias, Kröger, Nicolaus, Ribera Santasusana, Josep Maria, Richardson, Deborah, Rambaldi, Alessandro, Yañez, Lucrecia, Van Gelder, Michel, Drozd-Sokolowska, Joanna, Raj, Kavita, Yakoub-Agha, Ibrahim, Tournilhac, Olivier, and McLornan, Donal P.

Published
2024
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6. Post-transplant cyclophosphamide, calcineurin inhibitor, and mycophenolate mofetil compared to anti-thymocyte globulin, calcineurin inhibitor, and methotrexate combinations as graft-versus-host disease prophylaxis post allogeneic stem cell transplantation from sibling and unrelated donors in patients with acute myeloid leukemia: a study on behalf of the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation

Author

Nagler, Arnon, Labopin, Myriam, Swoboda, Ryszard, Schroeder, Thomas, Hamladji, Rose-Marie, Griskevicius, Laimonas, Salmenniemi, Urpu, Rambaldi, Alessandro, Mielke, Stephan, Kulagin, Alexander, Passweg, Jakob, Luft, Thomas, Gedde-Dahl, Tobias, Forcade, Edouard, Helbig, Grzegorz, Stelljes, Matthias, Castilla-Llorente, Cristina, Spyridonidis, Alexandros, Brissot, Eolia, Ciceri, Fabio, and Mohty, Mohamad

Published
2024
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8. Effects of the fungicide carbendazim on the behaviour of the zebrafish Danio rerio (Cypriniformes, Cyprinidae)

Author

de Oliveira, Marcos Roberto Beiral, Profeta, Isabela Vieira, Saraiva Raimondi Lopes, João Victor, Costa, Raissa Miranda, Matos e Chaib, Victória Rambaldi, Domingues, Anderson Gonçalves, Beirão, Marina Vale, Santos Rubio, Karina Taciana, Martucci, Maria Elvira Poleti, Eskinazi-Sant’Anna, Eneida Maria, and de Azevedo, Cristiano Schetini

Published
2024
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9. Neutrophil-to-lymphocyte ratio as a prognostic indicator of mortality in Polycythemia Vera: insights from a prospective cohort analysis

Author

Tiziano Barbui, Alessandra Carobbio, Arianna Ghirardi, Francesca Fenili, Maria Chiara Finazzi, Marta Castelli, Alessandro M. Vannucchi, Paola Guglielmelli, Alessandro Rambaldi, Naseema Gangat, and Ayalew Tefferi

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract We analyzed the neutrophil-to-lymphocyte ratio (NLR) in 1508 patients with PV and found that those with an NLR ≥ 5 were generally older, had a longer disease history, and had higher cardiovascular risk factors, more arterial thrombosis, and more aggressive blood counts, indicating a more proliferative disease. NLR was an accurate predictor of mortality, with patients with NLR ≥ 5 having significantly worse overall survival and more than twice the mortality rate compared to those with NLR

Published
2024
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10. Thrombosis in myeloproliferative neoplasms: a viewpoint on its impact on myelofibrosis, mortality, and solid tumors

Author

Tiziano Barbui, Arianna Ghirardi, Alessandra Carobbio, Valerio De Stefano, Alessandro Rambaldi, Ayalew Tefferi, and Alessandro M. Vannucchi

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract This viewpoint summarizes findings from analyses of large personal patient databases of myeloproliferative neoplasms (MPNs) to assess the impact of thrombosis on mortality, disease progression, and second cancers (SC). Despite advances, the current incidence of arterial and venous thrombosis remains a challenge. These events appear to signal a more aggressive disease course, as evidenced by their association with myelofibrosis progression and mortality using multistate models and time-dependent multivariable analysis. Inflammatory biomarkers, such as the neutrophil-to-lymphocyte ratio (NLR), are associated with the aggressiveness of polycythemia vera (PV) and essential thrombocythemia (ET), linking thrombosis to SC risk. This suggests a common inflammatory pathway likely influencing cardiovascular disease and cancer incidence. Notably, this is observed more frequently in younger patients, likely due to prolonged exposure to MPN and environmental inflammatory triggers. These data underscore the need for new studies to validate these associations, delineate the sequence of events, and identify therapeutic targets to mitigate thrombotic events and potentially improve overall patient outcomes in MPN.

Published
2024
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11. Genetically modified and unmodified cellular approaches to enhance graft versus leukemia effect, without increasing graft versus host disease: the use of allogeneic cytokine-induced killer cells

Author

Benedetta Rambaldi, Giuliana Rizzuto, Alessandro Rambaldi, and Martino Introna

Subjects
hematopoietic cell transplant, donor lymphocyte infusion (DLI), cytokine-induced killer (CIK) cells, leukemia, graft versus leukemia (GVL), chimeric antigen receptor (CAR), Immunologic diseases. Allergy, RC581-607
Abstract

Although allogeneic hematopoietic cell transplantation (HCT) represents a curative approach for many patients with hematological diseases, post-transplantation relapse occurs in 20-50% of cases, representing the primary cause of treatment failure and mortality. Alloreactive donor T cells are responsible for the graft versus leukemia (GvL) effect, which represents the key mechanism for the long-term curative effect of HCT. However, the downside is represented by graft versus host disease (GvHD), largely contributing to transplant-related mortality (TRM). Multiple factors play a role in regulating the delicate balance between GvL and GvHD, such as the optimization of the donor HLA and KIR match, the type of graft source, and the adaptive use of post-transplant cellular therapy. In addition to the standard donor lymphocyte infusion (DLI), several attempts were made to favor the GvL effect without increasing the GvHD risk. Selected DLI, NK DLI, activated DLI and more sophisticated genetically engineered cells can be employed. In this scenario, cytokine-induced killer (CIK) cells represent a suitable tool to boost GvL while minimizing GvHD. CIK cells are T lymphocytes activated in culture in the presence of monoclonal antibodies against CD3 (OKT3), interferon-gamma (IFN-g), and interleukin-2 (IL-2), characterized by the expression of markers typical of NK cells and T cells (CD3+, CD56+, with a prevalent CD8+ phenotype). CIK cells can mediate cytotoxicity through both MHC and non-MHC restricted recognition, which is the so‐called “dual‐functional capability” and display minimum alloreactivity. Allogeneic CIK cells showed a favorable rate of response, especially in the setting of minimal residual disease, with a rate of GvHD not exceeding 25%. Finally, the CIK cell platform can be adapted for chimeric antigen receptor (CAR) cell strategy, showing promising results in both preclinical and clinical settings. In this review, we describe the main immunological basis for the development of the GvL and the possible cellular therapy approaches used to boost it, with a particular focus on the use of CIK cells.

Published
2024
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15. Busulfan-fludarabine versus busulfan-cyclophosphamide for allogeneic transplant in acute myeloid leukemia: long term analysis of GITMO AML-R2 trial

Author

Cavallaro, Gianluca, Grassi, Anna, Pavoni, Chiara, Micò, Maria Caterina, Busca, Alessandro, Cavattoni, Irene Maria, Santarone, Stella, Borghero, Carlo, Olivieri, Attilio, Milone, Giuseppe, Chiusolo, Patrizia, Musto, Pellegrino, Saccardi, Riccardo, Patriarca, Francesca, Pane, Fabrizio, Saporiti, Giorgia, Rivela, Paolo, Terruzzi, Elisabetta, Cerretti, Raffaella, Marotta, Giuseppe, Carella, Angelo Michele, Nagler, Arnon, Russo, Domenico, Corradini, Paolo, Bernasconi, Paolo, Iori, Anna Paola, Castagna, Luca, Mordini, Nicola, Oldani, Elena, Di Grazia, Carmen, Bacigalupo, Andrea, and Rambaldi, Alessandro

Published
2024
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16. Rapid immune reconstitution following the infusion of autologous, Blinatumomab Expanded T-cells (BET) in patients with B-cell indolent NHL or CLL

Author

Gritti, Giuseppe, Ferrari, Silvia, Lussana, Federico, Barbui, Anna Maria, Landi, Francesco, Rondi, Monica, Putelli, Alessandro, Ballardini, Francesco, Quaresmini, Giulia, Paganessi, Muriel, Pavoni, Chiara, Ghirardi, Arianna, Gotti, Elisa, Capelli, Chiara, Golay, Josée, Introna, Martino, and Rambaldi, Alessandro

Published
2024
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18. PTCy versus ATG as graft-versus-host disease prophylaxis in mismatched unrelated stem cell transplantation

Author

Penack, Olaf, Abouqateb, Mouad, Peczynski, Christophe, Boreland, William, Gülbas, Zafer, Gedde-Dahl, Tobias, Castilla-Llorente, Cristina, Kröger, Nicolaus, Eder, Mathias, Rambaldi, Alessandro, Bonifazi, Francesca, Blau, Igor Wolfgang, Stelljes, Matthias, Dreger, Peter, Moiseev, Ivan, Schoemans, Hélène, Koenecke, Christian, and Peric, Zinaida

Published
2024
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19. GLP-1 receptor agonists-SGLT-2 inhibitors combination therapy and cardiovascular events after acute myocardial infarction: an observational study in patients with type 2 diabetes

Author

Marfella, Raffaele, Prattichizzo, Francesco, Sardu, Celestino, Rambaldi, Pier Francesco, Fumagalli, Carlo, Marfella, Ludovica Vittoria, La Grotta, Rosalba, Frigé, Chiara, Pellegrini, Valeria, D’Andrea, Davide, Cesaro, Arturo, Calabrò, Paolo, Pizzi, Carmine, Antonicelli, Roberto, Ceriello, Antonio, Mauro, Ciro, and Paolisso, Giuseppe

Published
2024
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21. Busulfan-fludarabine versus busulfan-cyclophosphamide for allogeneic transplant in acute myeloid leukemia: long term analysis of GITMO AML-R2 trial

Author

Gianluca Cavallaro, Anna Grassi, Chiara Pavoni, Maria Caterina Micò, Alessandro Busca, Irene Maria Cavattoni, Stella Santarone, Carlo Borghero, Attilio Olivieri, Giuseppe Milone, Patrizia Chiusolo, Pellegrino Musto, Riccardo Saccardi, Francesca Patriarca, Fabrizio Pane, Giorgia Saporiti, Paolo Rivela, Elisabetta Terruzzi, Raffaella Cerretti, Giuseppe Marotta, Angelo Michele Carella, Arnon Nagler, Domenico Russo, Paolo Corradini, Paolo Bernasconi, Anna Paola Iori, Luca Castagna, Nicola Mordini, Elena Oldani, Carmen Di Grazia, Andrea Bacigalupo, and Alessandro Rambaldi

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract We report the long-term results of a randomized trial (GITMO, AML-R2), comparing 1:1 the combination of busulfan and cyclophosphamide (BuCy2, n = 125) and the combination of busulfan and fludarabine (BuFlu, n = 127) as conditioning regimen in acute myeloid leukemia patients (median age 51 years, range 40–65) undergoing allogeneic hematopoietic stem cell transplantation. With a median follow-up of 6 years, significantly better non-relapse mortality (NRM) was confirmed in BuFlu recipients, which is sustained up to 4 years after transplant (10% vs. 20%, p = 0.0388). This difference was higher in patients older than 51 years (11% in BuFlu vs. 27% in BuCy2, p = 0.0262). The cumulative incidence of relapse, which was the first cause of death in the entire study population, did not differ between the two randomized arms. Similarly, the leukemia-free survival (LFS) and overall survival (OS) were not different in the two cohorts, even when stratifying patients per median age. Graft-and relapse-free survival (GRFS) in BuFlu arm vs. the BuCy2 arm was 25% vs. 20% at 4 years and 20% vs. 17% at 10 years. Hence, the benefit gained by NRM reduction is not offsets by an increased relapse. Leukemia relapse remains a major concern, urging the development of new therapeutic approaches.

Published
2024
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25. Ropeginterferon phase 2 randomized study in low-risk polycythemia vera: 5-year drug survival and efficacy outcomes

Author

Barbui, Tiziano, Carobbio, Alessandra, De Stefano, Valerio, Alvarez-Larran, Alberto, Ghirardi, Arianna, Carioli, Greta, Fenili, Francesca, Rossi, Elena, Ciceri, Fabio, Bonifacio, Massimiliano, Iurlo, Alessandra, Palandri, Francesca, Benevolo, Giulia, Pane, Fabrizio, Ricco, Alessandra, Carli, Giuseppe, Caramella, Marianna, Rapezzi, Davide, Musolino, Caterina, Siragusa, Sergio, Rumi, Elisa, Patriarca, Andrea, Cascavilla, Nicola, Mora, Barbara, Cacciola, Emma, Calabresi, Laura, Loscocco, Giuseppe Gaetano, Guglielmelli, Paola, Gesullo, Francesca, Betti, Silvia, Ramundo, Francesco, Lunghi, Francesca, Scaffidi, Luigi, Bucelli, Cristina, Cattaneo, Daniele, Vianelli, Nicola, Bellini, Marta, Finazzi, Maria Chiara, Tognoni, Gianni, Rambaldi, Alessandro, and Vannucchi, Alessandro Maria

Published
2024
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27. Assessing Chitinases and Neurofilament Light Chain as Biomarkers for Adult-Onset Leukodystrophies

Author

Paulo de Lima Serrano, Thaiane de Paulo Varollo Rodrigues, Leslyê Donato Pinto, Indiara Correia Pereira, Igor Braga Farias, Renan Brandão Rambaldi Cavalheiro, Patrícia Marques Mendes, Kaliny Oliveira Peixoto, João Paulo Barile, Daniel Delgado Seneor, Eduardo Gleitzmann Correa Silva, Acary Souza Bulle Oliveira, Wladimir Bocca Vieira de Rezende Pinto, and Paulo Sgobbi

Subjects
leukoencephalopathy, leukodystrophy, biomarker, chitotriosidase, CSF1R, adult-onset leukoencephalopathy with axonal spheroids and pigmented glia, Biology (General), QH301-705.5
Abstract

Leukodystrophies represent a large and complex group of inherited disorders affecting the white matter of the central nervous system. Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) is a rare leukodystrophy which still needs the proper identification of diagnostic, prognostic, and monitoring biomarkers. The aim of this study was to determine the diagnostic and prognostic value of chitinases and neurofilament light chain as biomarkers for ALSP. A cross-sectional study was performed to analyze cerebrospinal fluid levels of chitinases (chitotriosidase and chitinase 3-like 2) and neurofilament light chain in five different groups: (i) normal health individuals; (ii) patients with definitive diagnosis of ALSP and genetic confirmation; (iii) asymptomatic patients with CSF1R variants; (iv) patients with other adult-onset leukodystrophies; and (v) patients with amyotrophic lateral sclerosis (external control group). Chitinase levels showed a statistical correlation with clinical assessment parameters in ALSP patients. Chitinase levels were also distinct between ALSP and the other leukodystrophies. Significant differences were noted in the levels of chitinases and neurofilament light chain comparing symptomatic (ALSP) and asymptomatic individuals with CSF1R variants. This study is the first to establish chitinases as a potential biomarker for ALSP and confirms neurofilament light chain as a good biomarker for primary microgliopathies.

Published
2024
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28. Rapid immune reconstitution following the infusion of autologous, Blinatumomab Expanded T-cells (BET) in patients with B-cell indolent NHL or CLL

Author

Giuseppe Gritti, Silvia Ferrari, Federico Lussana, Anna Maria Barbui, Francesco Landi, Monica Rondi, Alessandro Putelli, Francesco Ballardini, Giulia Quaresmini, Muriel Paganessi, Chiara Pavoni, Arianna Ghirardi, Elisa Gotti, Chiara Capelli, Josée Golay, Martino Introna, and Alessandro Rambaldi

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Published
2024
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29. PTCy versus ATG as graft-versus-host disease prophylaxis in mismatched unrelated stem cell transplantation

Author

Olaf Penack, Mouad Abouqateb, Christophe Peczynski, William Boreland, Zafer Gülbas, Tobias Gedde-Dahl, Cristina Castilla-Llorente, Nicolaus Kröger, Mathias Eder, Alessandro Rambaldi, Francesca Bonifazi, Igor Wolfgang Blau, Matthias Stelljes, Peter Dreger, Ivan Moiseev, Hélène Schoemans, Christian Koenecke, and Zinaida Peric

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract There is an increased risk of GVHD and of non-relapse mortality (NRM) after allogeneic stem cell transplantations (alloSCT) when mismatched unrelated donors (MMUD) are used. In Europe, it is standard practice to use rabbit anti-thymocyte globulin (rATG) to reduce the high NRM and GVHD risks after MMUD alloSCT. As an alternative to rATG, post-transplantation Cyclophosphamide (PTCy) is in increasing clinical use. It is currently impossible to give general recommendations regarding preference for one method over another since comparative evidence from larger data sets is lacking. To improve the evidence base, we analyzed the outcome of rATG vs. PTCy prophylaxis in adult patients with hematologic malignancies undergoing first peripheral blood alloSCT from MMUD (9/10 antigen match) between Jan 2018 and June 2021 in the database of the European Society for Blood and Marrow Transplantation (EBMT). We performed multivariate analyses using the Cox proportional-hazards regression model. We included 2123 patients in the final analyses (PTCy, n = 583; rATG, n = 1540). p values and hazard ratios (HR) presented here are multivariate outcomes. Two years after alloSCT we found a lower NRM in the PTCy group of 18% vs. 24.9% in the rATG group; p = 0.028, HR 0.74. Overall survival in the PTCy cohort was higher with 65.7% vs. 55.7% in the rATG cohort; p

Published
2024
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31. FEASIBILITY AND OUTCOME OF FIRST-LINE AUTOTRANSPLANT-BASED TREATMENT IN NEWLY DIAGNOSED MULTIPLE MYELOMA PATIENTS AGED > 65 YEARS: MONOCENTRIC RETROSPECTIVE REAL-WORLD ANALYSIS

Author

Paola Stefanoni, Monica Galli, Laura Paris, Alessandro Rambaldi, Nicola Pittalis, Gianluca Cavallaro, and Chiara Pavoni

Subjects
real world analysis, Multiple myeloma, autologous stem cell transplantation (ASCT), Diseases of the blood and blood-forming organs, RC633-647.5
Abstract

We performed a monocentric, retrospective real-world analysis (RWA) to evaluate the feasibility and the main results of an autologous stem cell transplantation (ASCT)-based program in a cohort of 90 newly diagnosed multiple myeloma patients aged > 65 years who were deemed eligible to such program on the basis of a simplified frailty score. Seventy-six patients received at least one ASCT and 14 patients received also the second. Median progression-free survival was 42 months and overall survival was 84 months. These results compare well with those of other RWAs, and pave the way to further improvements upon incorporation of an anti-CD38+ monoclonal antibody in the ASCT programs.

Published
2024
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32. An international survey on canine urinary incontinence: case frequency, diagnosis, treatment and follow-up

Author

M. V. Falceto, R. Caccamo, A. M. Garrido, M. C. Pisu, M. T. Tejedor, P. Trerotoli, S. Nicoli, P. Zagarella, I. Lippi, E. García-Pedraza, J. Rambaldi, D. Kirilova, and O. Mitjana

Subjects
urinary incontinence, USMI, dog, questionnaire, recommendations, Veterinary medicine, SF600-1100
Abstract

IntroductionUrinary incontinence (UI) consists of involuntary leakage of urine during the storage phase of urination.MethodsAn anonymous survey was given to Spanish and Italian veterinarians about canine UI treated cases, diagnosis, treatment, follow-up, and professional interest.Results and discussionMost veterinarians treated ≤3 cases/quarter, resulting in the percentage of incontinence males being lower than that of females (1-4% vs 0-24%). The percentage of spayed incontinent females was lower in Spain (0-24%) than in Italy (75-100%). Most diagnoses were based on a diagnostic algorithm (Spain: 88.7%; Italy: 65.3%); patient report and history, blood work, urinalysis and abdominal ultrasound. Urethral/bladder pressure measurement was unusual (Spain: 0.2%; Italy: 2.4%). In Spain, radiology with contrast medium and CT urography (26.3% and 34.4%, respectively) were more frequent than in Italy (11.6% and 22.7%, respectively). When suspecting urethral sphincter mechanism incompetence pharmacological trial (Spain: 93.2%; Italy: 78.9%). The first-choice medical treatment was Phenylpropanolamine, followed by Ephedrine and Deslorelin. When pharmacotherapy failed, the most frequent option was drug change, followed by increased drug dosage/frequency of administration, surgical therapy and colposuspension. A review was completed after the first week of treatment followed by periodic reviews. Most of the respondents participated in continuing education only if UI occurred in their everyday practice (Spain: 63.0%; Italy: 55.4%) and about 30% responders did it regardless of the number of UI cases treated (Spain: 30.5%; Italy: 37.4%).ConclusionSome recommendations in clinical practice were made. UI can be underestimated by owners; therefore, a complete history should be obtained by veterinarians. Veterinarians should carefully evaluate if spaying is advisable considering it could increase UI risk. A step-by-step approach is recommended and a specific diagnostic-therapeutic algorithm for UI in dogs is provided. Conservative approaches (regular exercise, weight loss in overweight dogs and observing an “incontinence diary” to identify abnormal patterns of urination) are advisable.

Published
2024
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33. Evolution and legacy of East Asian aurochs

Author

Hou, Jiawen, Guan, Xiwen, Xia, Xiaoting, Lyu, Yang, Liu, Xin, Mazei, Yuri, Xie, Ping, Chang, Fengqin, Zhang, Xiaonan, Chen, Jialei, Li, Xinyi, Zhang, Fengwei, Jin, Liangliang, Luo, Xiaoyu, Sinding, Mikkel-Holger S., Sun, Xin, Achilli, Alessandro, Migliore, Nicola Rambaldi, Zhang, Dongju, Lenstra, Johannes A., Han, Jianlin, Fu, Qiaomei, Liu, Xinyi, Zhang, Xiaoming, Chen, Ningbo, Lei, Chuzhao, and Zhang, Hucai

Published
2024
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35. Unrelated donor transplantation with posttransplant cyclophosphamide vs ATG for myelodysplastic neoplasms

Author

Chalandon, Yves, Eikema, Diderik-Jan, Moiseev, Ivan, Ciceri, Fabio, Koster, Linda, Vydra, Jan, Passweg, Jakob, Rovira, Montserrat, Ozcelik, Tulay, Gedde-Dahl, Tobias, Kröger, Nicolaus, Potter, Victoria, Yakoub-Agha, Ibrahim, Rambaldi, Alessandro, Itälä-Remes, Maija, Tanase, Alina, Onida, Francesco, Gurnari, Carmelo, Scheid, Christof, Drozd-Sokolowska, Joanna, Raj, Kavita, McLornan, Donal P., and Robin, Marie

Published
2024
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36. GLP-1 receptor agonists-SGLT-2 inhibitors combination therapy and cardiovascular events after acute myocardial infarction: an observational study in patients with type 2 diabetes

Author

Raffaele Marfella, Francesco Prattichizzo, Celestino Sardu, Pier Francesco Rambaldi, Carlo Fumagalli, Ludovica Vittoria Marfella, Rosalba La Grotta, Chiara Frigé, Valeria Pellegrini, Davide D’Andrea, Arturo Cesaro, Paolo Calabrò, Carmine Pizzi, Roberto Antonicelli, Antonio Ceriello, Ciro Mauro, and Giuseppe Paolisso

Subjects
SGLT-2 inhibitors, GLP-1 receptor agonists, MACE, Heart failure, Myocardial infarction, Glucose-lowering drugs, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Abstract Background Few studies explored the effect of the combination of glucose sodium-cotransporter-2 inhibitors (SGLT-2i) and glucagon-like peptide-1 receptor agonists (GLP-1RA) on the incidence of cardiovascular events in patients with type 2 diabetes (T2D) and acute myocardial infarction (AMI). Methods We recruited patients with T2D and AMI undergoing percutaneous coronary intervention, treated with either SGLT-2i or GLP-1RA for at least 3 months before hospitalization. Subjects with HbA1c 50% was higher in the SGLT-2i/GLP-1RA group compared with both SGLT-2i and GLP-1RA groups. Interpretation The combination of SGLT-2i and GLP-1RA is associated with a reduced incidence of cardiovascular events in patients with T2D and AMI compared with either drug used alone, with a significant effect also on peri-infarcted myocardial rescue in patients without a second event. Trial registraition ClinicalTrials.gov ID: NCT06017544.

Published
2024
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37. Current incidence, severity, and management of veno-occlusive disease/sinusoidal obstruction syndrome in adult allogeneic HSCT recipients: an EBMT Transplant Complications Working Party study

Author

Ruutu, Tapani, Peczynski, Christophe, Houhou, Mohamed, Polge, Emmanuelle, Mohty, Mohamad, Kröger, Nicolaus, Moiseev, Ivan, Penack, Olaf, Salooja, Nina, Schoemans, Hélène, Duarte, Rafael F., Schroeder, Thomas, Passweg, Jakob, Wulf, Gerald G., Ganser, Arnold, Sica, Simona, Arat, Mutlu, Salmenniemi, Urpu, Broers, Annoek E. C., Bourhis, Jean Henri, Rambaldi, Alessandro, Maertens, Johan, Halaburda, Kazimierz, Zuckerman, Tsila, Labussière-Wallet, Hélène, Basak, Grzegorz, Koenecke, Christian, and Perić, Zinaida

Published
2023
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38. miR-126 identifies a quiescent and chemo-resistant human B-ALL cell subset that correlates with minimal residual disease

Author

Caserta, Carolina, Nucera, Silvia, Barcella, Matteo, Fazio, Grazia, Naldini, Matteo Maria, Pagani, Riccardo, Pavesi, Francesca, Desantis, Giacomo, Zonari, Erika, D’Angiò, Mariella, Capasso, Paola, Lombardo, Angelo, Merelli, Ivan, Spinelli, Orietta, Rambaldi, Alessandro, Ciceri, Fabio, Silvestri, Daniela, Valsecchi, Maria Grazia, Biondi, Andrea, Cazzaniga, Giovanni, and Gentner, Bernhard

Published
2023
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40. The impact of thrombosis on probabilities of death and disease progression in polycythemia vera: a multistate transition analysis of 1,545 patients

Author

Tiziano Barbui, Alessandra Carobbio, Juergen Thiele, Naseema Gangat, Elisa Rumi, Alessandro Rambaldi, Alessandro M. Vannucchi, Ayalew Tefferi, and IWG-MRT group

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract We applied a parametric Markov five-state model, on a well-characterized international cohort of 1,545 patients with polycythemia vera (PV; median age 61 years; females 51%), in order to examine the impact of incident thrombosis on the trajectory of death or disease progression. At a median follow-up of 6.9 years, 347 (23%) deaths, 50 (3%) blast phase (BP), and 138 (9%) fibrotic (post-PV MF) transformations were recorded. Incident thrombosis occurred at a rate of 2.62% pt/yr (arterial 1.59% and venous 1.05%). The probability of death, in the first 10 years, for 280 (18%) patients who developed thrombosis during follow-up was 40%, which was two-fold higher than that seen in the absence of thrombosis or any other transition state (20%; p

Published
2023
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44. Global genetic diversity, introgression, and evolutionary adaptation of indicine cattle revealed by whole genome sequencing

Author

Chen, Ningbo, Xia, Xiaoting, Hanif, Quratulain, Zhang, Fengwei, Dang, Ruihua, Huang, Bizhi, Lyu, Yang, Luo, Xiaoyu, Zhang, Hucai, Yan, Huixuan, Wang, Shikang, Wang, Fuwen, Chen, Jialei, Guan, Xiwen, Liu, Yangkai, Li, Shuang, Jin, Liangliang, Wang, Pengfei, Sun, Luyang, Zhang, Jicai, Liu, Jianyong, Qu, Kaixing, Cao, Yanhong, Sun, Junli, Liao, Yuying, Xiao, Zhengzhong, Cai, Ming, Mu, Lan, Siddiki, Amam Zonaed, Asif, Muhammad, Mansoor, Shahid, Babar, Masroor Ellahi, Hussain, Tanveer, Silva, Gamamada Liyanage Lalanie Pradeepa, Gorkhali, Neena Amatya, Terefe, Endashaw, Belay, Gurja, Tijjani, Abdulfatai, Zegeye, Tsadkan, Gebre, Mebrate Genet, Ma, Yun, Wang, Yu, Huang, Yongzhen, Lan, Xianyong, Chen, Hong, Migliore, Nicola Rambaldi, Colombo, Giulia, Semino, Ornella, Achilli, Alessandro, Sinding, Mikkel-Holger S., Lenstra, Johannes A., Cheng, Haijian, Lu, Wenfa, Hanotte, Olivier, Han, Jianlin, Jiang, Yu, and Lei, Chuzhao

Published
2023
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49. Global genetic diversity, introgression, and evolutionary adaptation of indicine cattle revealed by whole genome sequencing

Author

Ningbo Chen, Xiaoting Xia, Quratulain Hanif, Fengwei Zhang, Ruihua Dang, Bizhi Huang, Yang Lyu, Xiaoyu Luo, Hucai Zhang, Huixuan Yan, Shikang Wang, Fuwen Wang, Jialei Chen, Xiwen Guan, Yangkai Liu, Shuang Li, Liangliang Jin, Pengfei Wang, Luyang Sun, Jicai Zhang, Jianyong Liu, Kaixing Qu, Yanhong Cao, Junli Sun, Yuying Liao, Zhengzhong Xiao, Ming Cai, Lan Mu, Amam Zonaed Siddiki, Muhammad Asif, Shahid Mansoor, Masroor Ellahi Babar, Tanveer Hussain, Gamamada Liyanage Lalanie Pradeepa Silva, Neena Amatya Gorkhali, Endashaw Terefe, Gurja Belay, Abdulfatai Tijjani, Tsadkan Zegeye, Mebrate Genet Gebre, Yun Ma, Yu Wang, Yongzhen Huang, Xianyong Lan, Hong Chen, Nicola Rambaldi Migliore, Giulia Colombo, Ornella Semino, Alessandro Achilli, Mikkel-Holger S. Sinding, Johannes A. Lenstra, Haijian Cheng, Wenfa Lu, Olivier Hanotte, Jianlin Han, Yu Jiang, and Chuzhao Lei

Subjects
Science
Abstract

Abstract Indicine cattle, also referred to as zebu (Bos taurus indicus), play a central role in pastoral communities across a wide range of agro-ecosystems, from extremely hot semiarid regions to hot humid tropical regions. However, their adaptive genetic changes following their dispersal into East Asia from the Indian subcontinent have remained poorly documented. Here, we characterize their global genetic diversity using high-quality whole-genome sequencing data from 354 indicine cattle of 57 breeds/populations, including major indicine phylogeographic groups worldwide. We reveal their probable migration into East Asia was along a coastal route rather than inland routes and we detected introgression from other bovine species. Genomic regions carrying morphology-, immune-, and heat-tolerance-related genes underwent divergent selection according to Asian agro-ecologies. We identify distinct sets of loci that contain promising candidate variants for adaptation to hot semi-arid and hot humid tropical ecosystems. Our results indicate that the rapid and successful adaptation of East Asian indicine cattle to hot humid environments was promoted by localized introgression from banteng and/or gaur. Our findings provide insights into the history and environmental adaptation of indicine cattle.

Published
2023
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