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1. Susceptibility of Anopheles gambiae to Natural Plasmodium falciparum Infection: A Comparison between the Well-Established Anopheles gambiae s.s Line and a Newly Established Ugandan Anopheles gambiae s.s. Line

Author

Ayo, Daniel, Onyige, Ismail, Okoth, Joseph, Musasizi, Eric, Oruni, Ambrose, Ramjith, Jordache, Arinaitwe, Emmanuel, Rek, John C, Drakeley, Chris, Staedke, Sarah G, Donnelly, Martin J, Bousema, Teun, Conrad, Melissa, and Blanken, Sara Lynn

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Clinical Sciences, Vector-Borne Diseases, Malaria, Rare Diseases, Infectious Diseases, 2.2 Factors relating to the physical environment, Infection, Good Health and Well Being, Humans, Animals, Anopheles, Plasmodium falciparum, Uganda, Malaria, Falciparum, Mosquito Vectors, Medical and Health Sciences, Tropical Medicine, Biomedical and clinical sciences, Health sciences
Abstract

Much of our understanding of malaria transmission comes from mosquito feeding assays using Anopheles mosquitoes from colonies that are well adapted to membrane feeding. This raises the question whether results from colony mosquitoes lead to overestimates of outcomes in wild Anopheles mosquitoes. We successfully established an Anopheles colony using progeny of wild Anopheles gambiae s.s. mosquitoes (Busia mosquitoes) and directly compared their susceptibility to infection with Plasmodium falciparum with the widely used An. gambiae s.s. mosquitoes (Kisumu mosquitoes) using gametocyte-infected Ugandan donor blood. The proportion of infectious feeds did not differ between Busia (71.8%, 23/32) and Kisumu (68.8%, 22/32, P = 1.00) mosquitoes. When correcting for random effects of donor blood, we observed a 23% higher proportion of infected Busia mosquitoes than infected Kisumu mosquitoes (RR, 1.23; 95% CI, 1.10-1.38, P < 0.001). This study suggests that feeding assays with Kisumu mosquitoes do not overestimate outcomes in wild An. gambiae s.s. mosquitoes, the mosquito species most relevant to malaria transmission in Uganda.

Published
2024

2. Plasmodium falciparum gametocyte carriage in longitudinally monitored incident infections is associated with duration of infection and human host factors

Author

Andolina, Chiara, Ramjith, Jordache, Rek, John, Lanke, Kjerstin, Okoth, Joseph, Grignard, Lynn, Arinaitwe, Emmanuel, Briggs, Jessica, Bailey, Jeffrey, Aydemir, Ozkan, Kamya, Moses R, Greenhouse, Bryan, Dorsey, Grant, Staedke, Sarah G, Drakeley, Chris, Jonker, Marianne, and Bousema, Teun

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Clinical Sciences, Malaria, Prevention, Infectious Diseases, Clinical Research, Rare Diseases, Vector-Borne Diseases, 2.2 Factors relating to the physical environment, 2.1 Biological and endogenous factors, Infection, Good Health and Well Being, Animals, Humans, Plasmodium falciparum, Malaria, Falciparum, Asymptomatic Infections, Uganda, Culicidae
Abstract

Malaria transmission depends on the presence of Plasmodium gametocytes that are the only parasite life stage that can infect mosquitoes. Gametocyte production varies between infections and over the course of infections. Infection duration is highly important for gametocyte production but poorly quantified. Between 2017 and 2019 an all-age cohort of individuals from Tororo, eastern Uganda was followed by continuous passive and routine assessments. We longitudinally monitored 104 incident infections from 98 individuals who were sampled once every 28 days and on any day of symptoms. Among infections that lasted ≥ 3 months, gametocyte appearance was near-universal with 96% of infections having detectable gametocytes prior to clearance. However, most infections were of much shorter duration; 55.7% of asymptomatic infections were detected only once. When considering all asymptomatic infections, regardless of their duration, only 36.3% had detectable gametocytes on at least one time-point prior to parasite clearance. Infections in individuals with sickle-cell trait (HbAS) were more likely to have gametocytes detected (Hazard Rate (HR) = 2.68, 95% CI 1.12, 6.38; p = 0.0231) and had gametocytes detected at higher densities (Density Ratio (DR) = 9.19, 95% CI 2.79, 30.23; p = 0.0002) compared to infections in wildtype (HbAA) individuals. Our findings suggest that a large proportion of incident infections is too short in duration and of too low density to contribute to onward transmission.

Published
2023

3. Effect of weekly fever-screening and treatment and monthly RDT testing and treatment on the infectious reservoir of malaria parasites in Burkina Faso: a cluster-randomised trial

Author

Collins, Katharine A, Ouedraogo, Alphonse, Guelbeogo, Wamdaogo Moussa, Soulama, Issiaka, Ouattara, Maurice S, Sombie, Salif, Ouedraogo, Nicolas, Coulibaly, Aboubacar S, Nombre, Apollinaire, Lanke, Kjerstin, Ramjith, Jordache, Awandu, Shehu S, Serme, Samuel S, Henry, Noelie, Stone, Will, Ouedraogo, Issa N, Diarra, Amidou, Holden, Tobias M, Sirima, Sodiomon B, Bradley, John, Soremekun, Seyi, Selvaraj, Prashanth, Gerardin, Jaline, Drakeley, Chris, Bousema, Teun, and Tiono, Alfred B

Published
2024
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4. Plasmodium falciparum gametocyte production correlates with genetic markers of parasite replication but is not influenced by experimental exposure to mosquito biting

Author

Blanken, Sara Lynn, Barry, Aissata, Lanke, Kjerstin, Guelbeogo, Moussa, Ouedraogo, Alphonse, Soulama, Issiaka, Coulibaly, Sam Aboubacar, Teelen, Karina, Graumans, Wouter, Dumont, Elin, Stone, Will, Ramjith, Jordache, Marti, Matthias, Andrade, Carolina M., Drakeley, Chris, Collins, Katharine, Tiono, Alfred, and Bousema, Teun

Published
2024
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5. Dynamics of asymptomatic Plasmodium falciparum and Plasmodium vivax infections and their infectiousness to mosquitoes in a low transmission setting of Ethiopia: a longitudinal observational study

Author

Hailemeskel, Elifaged, Tebeje, Surafel K., Ramjith, Jordache, Ashine, Temesgen, Lanke, Kjerstin, Behaksra, Sinknesh W., Emiru, Tadele, Tsegaye, Tizita, Gashaw, Abrham, Kedir, Soria, Chali, Wakweya, Esayas, Endashaw, Tafesse, Temesgen, Abera, Haile, Bulto, Mikiyas Gebremichael, Shumie, Girma, Petros, Beyene, Mamo, Hassen, Drakeley, Chris, Gadisa, Endalamaw, Bousema, Teun, and Tadesse, Fitsum G.

Published
2024
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6. Potent transmission-blocking monoclonal antibodies from naturally exposed individuals target a conserved epitope on Plasmodium falciparum Pfs230

Author

Ivanochko, Danton, Fabra-García, Amanda, Teelen, Karina, van de Vegte-Bolmer, Marga, van Gemert, Geert-Jan, Newton, Jocelyn, Semesi, Anthony, de Bruijni, Marloes, Bolscher, Judith, Ramjith, Jordache, Szabat, Marta, Vogt, Stefanie, Kraft, Lucas, Duncan, Sherie, Lee, Shwu-Maan, Kamya, Moses R., Feeney, Margaret E., Jagannathan, Prasanna, Greenhouse, Bryan, Sauerwein, Robert W., Richter King, C., MacGill, Randall S., Bousema, Teun, Jore, Matthijs M., and Julien, Jean-Philippe

Published
2023
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8. Safety, tolerability, and Plasmodium falciparum transmission-reducing activity of monoclonal antibody TB31F: a single-centre, open-label, first-in-human, dose-escalation, phase 1 trial in healthy malaria-naive adults

Author

van der Boor, Saskia C, Smit, Merel J, van Beek, Stijn W, Ramjith, Jordache, Teelen, Karina, van de Vegte-Bolmer, Marga, van Gemert, Geert-Jan, Pickkers, Peter, Wu, Yimin, Locke, Emily, Lee, Shwu-Maan, Aponte, John, King, C Richter, Birkett, Ashley J, Miura, Kazutoyo, Ayorinde, Morolayo A, Sauerwein, Robert W, ter Heine, Rob, Ockenhouse, Christian F, Bousema, Teun, Jore, Matthijs M, and McCall, Matthew B B

Published
2022
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9. Vaccination with a structure-based stabilized version of malarial antigen Pfs48/45 elicits ultra-potent transmission-blocking antibody responses

Author

McLeod, Brandon, Mabrouk, Moustafa T., Miura, Kazutoyo, Ravichandran, Rashmi, Kephart, Sally, Hailemariam, Sophia, Pham, Thao P., Semesi, Anthony, Kucharska, Iga, Kundu, Prasun, Huang, Wei-Chiao, Johnson, Max, Blackstone, Alyssa, Pettie, Deleah, Murphy, Michael, Kraft, John C., Leaf, Elizabeth M., Jiao, Yang, van de Vegte-Bolmer, Marga, van Gemert, Geert-Jan, Ramjith, Jordache, King, C. Richter, MacGill, Randall S., Wu, Yimin, Lee, Kelly K., Jore, Matthijs M., King, Neil P., Lovell, Jonathan F., and Julien, Jean-Philippe

Published
2022
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11. Sources of persistent malaria transmission in a setting with effective malaria control in eastern Uganda: a longitudinal, observational cohort study

Author

Andolina, Chiara, Rek, John C, Briggs, Jessica, Okoth, Joseph, Musiime, Alex, Ramjith, Jordache, Teyssier, Noam, Conrad, Melissa, Nankabirwa, Joaniter I, Lanke, Kjerstin, Rodriguez-Barraquer, Isabel, Meerstein-Kessel, Lisette, Arinaitwe, Emmanuel, Olwoch, Peter, Rosenthal, Philip J, Kamya, Moses R, Dorsey, Grant, Greenhouse, Bryan, Drakeley, Chris, Staedke, Sarah G, and Bousema, Teun

Published
2021
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13. Understanding and maximising the community impact of seasonal malaria chemoprevention in Burkina Faso (INDIE-SMC): study protocol for a cluster randomised evaluation trial

Author

Moreno, Marta, primary, Barry, Aissata, additional, Gmeiner, Markus, additional, Yaro, Jean Baptist, additional, Sermé, Samuel S, additional, Byrne, Isabel, additional, Ramjith, Jordache, additional, Ouedraogo, Alphonse, additional, Soulama, Issiaka, additional, Grignard, Lynn, additional, Soremekun, Seyi, additional, Koele, Simon, additional, ter Heine, Rob, additional, Ouedraogo, Amidou Z, additional, Sawadogo, Jean, additional, Sanogo, Edith, additional, Ouedraogo, Issa N, additional, Hien, Denise, additional, Sirima, Sodiomon Bienvenu, additional, Bradley, John, additional, Bousema, Teun, additional, Drakeley, Chris, additional, and Tiono, Alfred B, additional

Published
2024
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18. Recurrent events analysis with piece-wise exponential additive mixed models.

Author

Ramjith, Jordache, Bender, Andreas, Roes, Kit C. B., and Jonker, Marianne A.

Subjects
*DISEASE relapse, *CHRONIC diseases, *ADDITIVES, *MALARIA, *NONLINEAR analysis
Abstract

Recurrent events analysis plays an important role in many applications, including the study of chronic diseases or recurrence of infections. Historically, many models for recurrent events have been variants of the Cox model. In this article we introduce and describe the application of the piece-wise exponential Additive Mixed Model (PAMM) for recurrent events analysis and illustrate how PAMMs can be used to flexibly model the dependencies in recurrent events data. Simulations confirm that PAMMs provide unbiased estimates as well as equivalence to the Cox model when proportional hazards are assumed. Applications to recurrence of staphylococcus aureus and malaria in children illustrate the estimation of seasonality, bivariate non-linear effects, multiple timescales and relaxation of the proportional hazards assumption via time-varying effects. The R package pammtools is extended to facilitate estimation and visualization of PAMMs for recurrent events data. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Susceptibility of Anopheles gambiae to Natural Plasmodium falciparum Infection: A Comparison between the Well-Established Anopheles gambiae s.s Line and a Newly Established Ugandan Anopheles gambiae s.s. Line

Author

Ayo, Daniel, primary, Onyige, Ismail, additional, Okoth, Joseph, additional, Musasizi, Eric, additional, Oruni, Ambrose, additional, Ramjith, Jordache, additional, Arinaitwe, Emmanuel, additional, Rek, John C., additional, Drakeley, Chris, additional, Staedke, Sarah G., additional, Donnelly, Martin J., additional, Bousema, Teun, additional, Conrad, Melissa, additional, and Blanken, Sara Lynn, additional

Published
2023
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21. Prediction of Long-Term Physical, Mental, and Cognitive Problems Following Critical Illness: Development and External Validation of the PROSPECT Prediction Model*

Author

van Sleeuwen, Dries, primary, Zegers, Marieke, additional, Ramjith, Jordache, additional, Cruijsberg, Juliette K., additional, Simons, Koen S., additional, van Bommel, Daniëlle, additional, Burgers-Bonthuis, Dominique, additional, Koeter, Julia, additional, Bisschops, Laurens L. A., additional, Janssen, Inge, additional, Rettig, Thijs C. D., additional, van der Hoeven, Johannes G., additional, van de Laar, Floris A., additional, and van den Boogaard, Mark, additional

Published
2023
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23. Multimodal Balance Training Supported by Rhythmic Auditory Stimuli in Parkinson Disease: Effects in Freezers and Nonfreezers

Author

Capato, Tamine T.C., de Vries, Nienke M., IntHout, Joanna, Ramjith, Jordache, Barbosa, Egberto R., Nonnekes, Jorik, and Bloem, Bastiaan R.

Subjects
Care and treatment, Physiological aspects, Methods, Health aspects, Parkinson disease -- Care and treatment, Auditory perception -- Health aspects -- Physiological aspects, Movement therapy -- Methods, Sensory stimulation -- Health aspects -- Methods, Gait disorders -- Care and treatment, Exercise therapy -- Methods, Parkinson's disease -- Care and treatment
Abstract

Nonpharmacological interventions are an important element of the management of gait and balance impairments in people with Parkinson disease (PD). (1,2) Particularly, physical therapy can improve gait and balance. (3-7) [...], Objective. To fulfill the potential of nonpharmacological interventions for people with Parkinson disease (PD), individually tailored treatment is needed. Multimodal balance training supported by rhythmic auditory stimuli (RAS) can improve balance and gait in people with PD. The purpose of this study was to determine whether both freezers and nonfreezers benefit. Methods. A secondary analysis was conducted on a large randomized controlled trial that included 154 patients with PD (Hoehn & Yahr Stages 1-3 while ON-medication) who were assigned randomly to 3 groups: (1) multimodal balance training with RAS delivered by a metronome (RAS-supported multimodal balance training); (2) regular multimodal balance training without rhythmic auditory cues; and (3) a control intervention (involving an educational program). Training was performed for 5 weeks, twice per week. The primary outcome was the Mini-BESTest score directly after the training period. Assessments were performed by a single, masked assessor at baseline, directly postintervention, and after 1-month and 6-month follow-up. Outcomes were analyzed in 1 analysis, and the results were presented separately for freezers and nonfreezers with a linear mixed model, adjusted for baseline Mini-BESTest scores, Unified Parkinson&apos;s Disease Rating Scale scores, and levodopa equivalent dose. Results. In both freezers and nonfreezers, both RAS-supported multimodal training and regular training significantly improved the Mini-BESTest scores compared with baseline scores and with the control group scores. The improvement was larger for RAS-supported training compared with regular training, for both freezers and nonfreezers. Only the RAS-supported training group retained the improvements compared with baseline measurements at 6-month follow-up, and this was true for both freezers and nonfreezers. Conclusions. RAS-supported multimodal training is effective in improving balance performance in both freezers and nonfreezers. Impact. Until this study, it was unknown whether both freezers and nonfreezers could benefit from multimodal balance training. With this information, clinicians who work with people with PD will be better able to apply personalized gait rehabilitation. Lay Summary. Adding rhythmic auditory stimuli (RAS) to balance training is beneficial for both freezers and nonfreezers, at least in persons with mild to moderate disease stages. This RAS-supported multimodal training has good potential for a wider clinical implementation with good long-term effects.

Published
2020
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24. A transmission bottleneck for malaria? Quantification of sporozoite expelling from laboratory and natural P. falciparum infections

Author

Andolina, Chiara, primary, Graumans, Wouter, additional, Guelbeogo, Moussa, additional, van Gemert, Geert Jan, additional, Ramjith, Jordache, additional, Harouna, Soré, additional, Soumanaba, Zongo, additional, Stoter, Rianne, additional, Vegte-Bolmer, Marga, additional, Pangos, Martina, additional, Sinnis, Photini, additional, Collins, Katharine, additional, Staedke, Sarah G, additional, Tiono, Alfred B, additional, Drakeley, Chris, additional, Lanke, Kjerstin, additional, and Bousema, Teun, additional

Published
2023
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25. Prediction of Long-Term Physical, Mental, and Cognitive Problems Following Critical Illness: Development and External Validation of the PROSPECT Prediction Model.

Author

van Sleeuwen, Dries, Zegers, Marieke, Ramjith, Jordache, Cruijsberg, Juliette K., Simons, Koen S., van Bommel, Daniëlle, Burgers-Bonthuis, Dominique, Koeter, Julia, Bisschops, Laurens L. A., Janssen, Inge, Rettig, Thijs C. D., van der Hoeven, Johannes G., van de Laar, Floris A., and van den Boogaard, Mark

Published
2024
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26. Preoperative risk stratification in endometrial cancer (ENDORISK) by a Bayesian network model: A development and validation study

Author

Reijnen, Casper, Gogou, Evangelia, Visser, Nicole C. M., Engerud, Hilde, Ramjith, Jordache, van der Putten, Louis J. M., van de Vijver, Koen, Santacana, Maria, Bronsert, Peter, Bulten, Johan, Hirschfeld, Marc, Colas, Eva, Gil-Moreno, Antonio, Reques, Armando, Mancebo, Gemma, Krakstad, Camilla, Trovik, Jone, Haldorsen, Ingfrid S., Huvila, Jutta, Koskas, Martin, Weinberger, Vit, Bednarikova, Marketa, Hausnerova, Jitka, van der Wurff, Anneke A. M., Matias-Guiu, Xavier, Amant, Frederic, Massuger, Leon F. A. G., Snijders, Marc P. L. M., Küsters-Vandevelde, Heidi V. N., Lucas, Peter J. F., and Pijnenborg, Johanna M. A.

Subjects
Care and treatment, Prognosis, Risk factors, Health aspects, Cancer treatment -- Health aspects, Tumor proteins -- Care and treatment -- Risk factors -- Prognosis, Machine learning -- Health aspects, Cancer -- Care and treatment -- Risk factors -- Prognosis, Endometrial cancer -- Prognosis -- Care and treatment -- Risk factors, Cancer research -- Health aspects, Estrogens -- Health aspects, Progesterone -- Health aspects, Cancer metastasis -- Care and treatment -- Prognosis -- Risk factors
Abstract

Author(s): Casper Reijnen 1,2,*, Evangelia Gogou 3, Nicole C. M. Visser 4, Hilde Engerud 5,6, Jordache Ramjith 7, Louis J. M. van der Putten 1, Koen van de Vijver 8, [...], Background Bayesian networks (BNs) are machine-learning-based computational models that visualize causal relationships and provide insight into the processes underlying disease progression, closely resembling clinical decision-making. Preoperative identification of patients at risk for lymph node metastasis (LNM) is challenging in endometrial cancer, and although several biomarkers are related to LNM, none of them are incorporated in clinical practice. The aim of this study was to develop and externally validate a preoperative BN to predict LNM and outcome in endometrial cancer patients. Methods and findings Within the European Network for Individualized Treatment of Endometrial Cancer (ENITEC), we performed a retrospective multicenter cohort study including 763 patients, median age 65 years (interquartile range [IQR] 58-71), surgically treated for endometrial cancer between February 1995 and August 2013 at one of the 10 participating European hospitals. A BN was developed using score-based machine learning in addition to expert knowledge. Our main outcome measures were LNM and 5-year disease-specific survival (DSS). Preoperative clinical, histopathological, and molecular biomarkers were included in the network. External validation was performed using 2 prospective study cohorts: the Molecular Markers in Treatment in Endometrial Cancer (MoMaTEC) study cohort, including 446 Norwegian patients, median age 64 years (IQR 59-74), treated between May 2001 and 2010; and the PIpelle Prospective ENDOmetrial carcinoma (PIPENDO) study cohort, including 384 Dutch patients, median age 66 years (IQR 60-73), treated between September 2011 and December 2013. A BN called ENDORISK (preoperative risk stratification in endometrial cancer) was developed including the following predictors: preoperative tumor grade; immunohistochemical expression of estrogen receptor (ER), progesterone receptor (PR), p53, and L1 cell adhesion molecule (L1CAM); cancer antigen 125 serum level; thrombocyte count; imaging results on lymphadenopathy; and cervical cytology. In the MoMaTEC cohort, the area under the curve (AUC) was 0.82 (95% confidence interval [CI] 0.76-0.88) for LNM and 0.82 (95% CI 0.77-0.87) for 5-year DSS. In the PIPENDO cohort, the AUC for 5-year DSS was 0.84 (95% CI 0.78-0.90). The network was well-calibrated. In the MoMaTEC cohort, 249 patients (55.8%) were classified with Conclusions In this study, we illustrated how BNs can be used for individualizing clinical decision-making in oncology by incorporating easily accessible and multimodal biomarkers. The network shows the complex interactions underlying the carcinogenetic process of endometrial cancer by its graphical representation. A prospective feasibility study will be needed prior to implementation in the clinic.

Published
2020
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27. Development and External Validation of a Prediction Model for Quality of Life of ICU Survivors: A Subanalysis of the MONITOR-IC Prospective Cohort Study

Author

Porter, Lucy L., primary, Simons, Koen S., additional, Ramjith, Jordache, additional, Corsten, Stijn, additional, Westerhof, Brigitte, additional, Rettig, Thijs C. D., additional, Ewalds, Esther, additional, Janssen, Inge, additional, van der Hoeven, Johannes G., additional, van den Boogaard, Mark, additional, and Zegers, Marieke, additional

Published
2023
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28. Naturally acquired antibodies to gametocyte antigens are associated with reduced transmission of Plasmodium vivax gametocytes to Anopheles arabiensis mosquitoes

Author

Tebeje, Surafel K., primary, Chali, Wakweya, additional, Hailemeskel, Elifaged, additional, Ramjith, Jordache, additional, Gashaw, Abrham, additional, Ashine, Temesgen, additional, Nebret, Desalegn, additional, Esayas, Endashaw, additional, Emiru, Tadele, additional, Tsegaye, Tizita, additional, Teelen, Karina, additional, Lanke, Kjerstin, additional, Takashima, Eizo, additional, Tsuboi, Takafumi, additional, Salinas, Nichole D., additional, Tolia, Niraj H., additional, Narum, David, additional, Drakeley, Chris, additional, Witkowski, Benoit, additional, Vantaux, Amelie, additional, Jore, Matthijs M., additional, Stone, William J. R., additional, Hansen, Ivo S., additional, Tadesse, Fitsum G., additional, and Bousema, Teun, additional

Published
2023
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29. Active Screening and Treatment Significantly Reduces the Infectious Reservoir of Malaria in Burkina Faso: Results from a Randomised Trial

Author

Collins, Katharine, primary, Ouedraogo, Alphonse, additional, Guelbeogo, Moussa W., additional, Soulama, Issiaka, additional, Ouattara, San Maurice, additional, Sombie, Salif, additional, Ouedraogo, Nicolas, additional, Coulibaly, Sam, additional, Coulibaly, Aboubacar S., additional, Nombre, Apollinaire, additional, Lanke, Kjerstin, additional, Ramjith, Jordache, additional, Awandu, Shehu, additional, Serme, Samuel, additional, Henry, Noelie, additional, Stone, William, additional, Nébié, Issa, additional, Diarra, Amidou, additional, Holden, Tobias McKenzie, additional, Sirima, Sodiomon B., additional, Bradley, John, additional, Soremekun, Seyi, additional, Selvaraj, Prashanth, additional, Gerardin, Jaline, additional, Drakeley, Chris, additional, Bousema, Teun, additional, and Tiono, Alfred B., additional

Published
2023
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32. Plasmodium falciparum gametocyte production in longitudinally monitored incident infections is associated with duration of infection and human host factors

Author

Andolina, Chiara, primary, Ramjith, Jordache, additional, Rek, John, additional, Lanke, Kjerstin, additional, Okoth, Joseph, additional, Grignard, Lynn, additional, Arinaitwe, Emmanuel, additional, Briggs, Jessica, additional, Bailey, Jeffrey, additional, Aydemir, Ozkan, additional, Kamya, Moses R, additional, Greenhouse, Bryan, additional, Dorsey, Grant, additional, Staedke, Sarah G, additional, Drakeley, Chris, additional, Jonker, Marianne, additional, and Bousema, Teun, additional

Published
2022
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35. Pharyngo-Esophageal Modulatory Swallow Responses to Bolus Volume and Viscosity Across Time

Author

Nollet, Joeke L., Cajander, Per, Ferris, Lara F., Ramjith, Jordache, Omari, Taher I., Savilampi, Johanna, Nollet, Joeke L., Cajander, Per, Ferris, Lara F., Ramjith, Jordache, Omari, Taher I., and Savilampi, Johanna

Abstract

OBJECTIVES/HYPOTHESIS: Modulation of the pharyngeal swallow to bolus volume and viscosity is important for safe swallowing and is commonly studied using high-resolution pharyngeal manometry (HRPM). Use of unidirectional pressure sensor technology may, however, introduce variability in swallow measures and a fixed bolus administration protocol may induce time and order effects. We aimed to overcome these limitations and to investigate the effect of time by repeating randomized measurements using circumferential pressure sensor technology. STUDY DESIGN: Sub-set analysis of data from the placebo arm of a randomized, repeated measures trial. METHODS: HRPM with impedance was recorded using a solid-state catheter with 36 circumferential pressure sensors and 18 impedance segments straddling from hypopharynx to stomach. Testing included triplicates of 5, 10, and 20 ml thin liquid and 10 ml thick liquid boluses, the order of the thin liquid boluses was randomized. The swallow challenges were repeated approximately 10 minutes after finishing the baseline measurement. RESULTS: We included 19 healthy adults (10/9 male/female; age 24.5 ± 4.1 year). Intrabolus pressure, all upper esophageal sphincter (UES) opening and relaxation metrics, and flow timing metrics increased with larger volumes. A thicker viscosity decreased UES relaxation time, UES basal pressure, and flow timing metrics, whereas UES opening extent increased. Pre-swallow UES basal pressure and post-swallow UES contractile integral decreased over time. CONCLUSION: Using circumferential pressure sensor technology, the effects of volume and viscosity were largely consistent with previous reports. UES contractile pressures reduced over time. The growing body of literature offers a benchmark for recognizing aberrant pharyngo-esophageal motor responses. LEVEL OF EVIDENCE: 3 Laryngoscope, 2021., Funding agency:College of Medicine and Public Health, Flinders University

Published
2022
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36. Asymptomatic School-Aged Children Are Important Drivers of Malaria Transmission in a High Endemicity Setting in Uganda

Author

Rek, John, primary, Blanken, Sara Lynn, additional, Okoth, Joseph, additional, Ayo, Daniel, additional, Onyige, Ismail, additional, Musasizi, Eric, additional, Ramjith, Jordache, additional, Andolina, Chiara, additional, Lanke, Kjerstin, additional, Arinaitwe, Emmanuel, additional, Olwoch, Peter, additional, Collins, Katharine A, additional, Kamya, Moses R, additional, Dorsey, Grant, additional, Drakeley, Chris, additional, Staedke, Sarah G, additional, Bousema, Teun, additional, and Conrad, Melissa D, additional

Published
2022
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37. Identification of Highly Potent Transmission-Blocking Human Monoclonal Antibodies to Plasmodium falciparum Pfs230 in Naturally Exposed Individuals

Author

Ivanochko, Danton, primary, Fabra-García, Amanda, additional, Teelen, Karina, additional, van de Vegte-Bolmer, Marga, additional, van Gemert, Geert-Jan, additional, Newton, Jocelyn, additional, Semesi, Anthony, additional, de Bruijni, Marloes, additional, Bolscher, Judith, additional, Ramjith, Jordache, additional, Szabat, Marta, additional, Vogt, Stefanie, additional, Kraft, Lucas, additional, Duncan, Sherie, additional, Lee, Shwu-Maan, additional, Kamya, Moses, additional, Feeney, Margo, additional, Jagannathan, Prasanna, additional, Greenhouse, Bryan, additional, Sauerwein, Robert W., additional, King, C. Richter, additional, MacGill, Randall, additional, Bousema, Teun, additional, Jore, Matthijs M., additional, and Julien, Jean-Philippe, additional

Published
2022
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38. Safety, Tolerability and Plasmodium Falciparum Transmission-Reducing Activity of Monoclonal Antibody TB31F: An Open-Label, First-in-Human, Trial in Healthy Malaria-Naïve Adults

Author

van der Boor, Saskia C., primary, Smit, Merel, additional, van Beek, Stijn W., additional, Ramjith, Jordache, additional, Teelen, Karina, additional, van de Vegte-Bolmer, Marga, additional, van Gemert, Geert-Jan, additional, Pickkers, Peter, additional, Wu, Yimin, additional, Locke, Emily, additional, Lee, Shwu-Maan, additional, King, C. Richter, additional, Birkett, Ashley J., additional, Miura, Kazutoyo, additional, Ayorinde, Morolayo A., additional, Sauerwein, Robert W., additional, ter Heine, Rob, additional, Ockenhouse, Christian F., additional, Bousema, Teun, additional, Jore, Matthijs M., additional, and McCall, Matthew, additional

Published
2022
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42. Persistent malaria transmission from asymptomatic children despite highly effective malaria control in eastern Uganda

Author

Andolina, Chiara, primary, Rek, John, additional, Briggs, Jessica, additional, Okoth, Joseph, additional, Musiime, Alex, additional, Ramjith, Jordache, additional, Teyssier, Noam, additional, Conrad, Melissa, additional, Nankabirwa, Joaniter I., additional, Lanke, Kjerstin, additional, Rodriguez-Barraquer, Isabel, additional, Meerstein-Kessel, Lisette, additional, Arinaitwe, Emmanuel, additional, Olwoch, Peter, additional, Rosenthal, Philip J., additional, Kamya, Moses R., additional, Dorsey, Grant, additional, Greenhouse, Bryan, additional, Drakeley, Chris, additional, Staedke, Sarah G., additional, and Bousema, Teun, additional

Published
2021
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43. Risk factors for in-hospital mortality in laboratory-confirmed COVID-19 patients in the Netherlands: A competing risk survival analysis

Author

Nijman, Gerine, primary, Wientjes, Maike, additional, Ramjith, Jordache, additional, Janssen, Nico, additional, Hoogerwerf, Jacobien, additional, Abbink, Evertine, additional, Blaauw, Marc, additional, Dofferhoff, Ton, additional, van Apeldoorn, Marjan, additional, Veerman, Karin, additional, de Mast, Quirijn, additional, ten Oever, Jaap, additional, Hoefsloot, Wouter, additional, Reijers, Monique H., additional, van Crevel, Reinout, additional, and van de Maat, Josephine S., additional

Published
2021
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44. Associations between Environmental dust composition and Atopic Dermatitis in urban and rural settings

Author

Trikamjee, Thulja, primary, Basera, Wisdom, additional, Botha, Maresa, additional, Facey‐Thomas, Heidi E., additional, Gaunt, Ben, additional, Genuneit, Jon, additional, Gray, Claudia L., additional, Hadebe, Sabelo, additional, Hlela, Carol, additional, Kirstein, Frank, additional, Lunjani, Nonhlanhla, additional, Mankahla, Avumile, additional, Ramjith, Jordache, additional, and Levin, Michael, additional

Published
2021
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45. Molecular IgE sensitization profiles of urban and rural children in South Africa

Author

Mittermann, Irene, primary, Dzoro, Sheron, additional, Gattinger, Pia, additional, Botha, Maresa, additional, Basera, Wisdom, additional, Facey‐Thomas, Heidi E., additional, Gaunt, Ben, additional, Genuneit, Jon, additional, Gray, Claudia L., additional, Hlela, Carol, additional, Flicker, Sabine, additional, Lunjani, Nonhlanhla, additional, Mankahla, Avumile, additional, Ramjith, Jordache, additional, Valenta, Rudolf, additional, and Levin, Michael E, additional

Published
2020
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48. Longitudinal Population Dynamics of Staphylococcus aureus in the Nasopharynx During the First Year of Life

Author

Abdulgader, Shima M., Robberts, Lourens, Ramjith, Jordache, Nduru, Polite M., Dube, Felix, Gardner-Lubbe, Sugnet, Zar, Heather J., and Nicol, Mark P.

Subjects
Staphylococcus aureus, longitudinal, genotype diversity, Genetics, Molecular Medicine, infancy, Genetics (clinical), Original Research, carriage
Abstract

Background: Staphylococcus aureus colonization is a risk factor for invasive disease. Few studies have used strain genotype data to study S. aureus acquisition and carriage patterns. We investigated S. aureus nasopharyngeal carriage in infants in an intensively sampled South African birth cohort. Methods: Nasopharyngeal swabs were collected at birth and fortnightly from 137 infants through their first year of life. S. aureus was characterized by spa-typing. The incidence of S. aureus acquisition, and median carriage duration for each genotype was determined. S. aureus carriage patterns were defined by combining the carrier index (proportion of samples testing positive for S. aureus) with genotype diversity measures. Persistent or prolonged carriage were defined by a carrier index ≥0.8 or ≥0.5, respectively. Risk factors for time to acquisition of S. aureus were determined. Results: Eighty eight percent (121/137) of infants acquired S. aureus at least once. The incidence of acquisition at the species and genotype level was 1.83 and 2.8 episodes per child-year, respectively. No children had persistent carriage (defined as carrier index of >0.8). At the species level 6% had prolonged carriage, while only 2% had prolonged carriage with the same genotype. Carrier index correlated with the absolute number of spa-CCs carried by each infant (r = 0.5; 95% CI 0.35–0.62). Time to first acquisition of S. aureus was shorter in children from households with ≥5 individuals (HR 1.06, 95% CI 1.07–1.43), with S. aureus carrier mothers (HR; 1.5, 95% CI 1.2–2.47), or with a positive tuberculin skin test during the first year of life (HR; 1.81, 95% CI 0.97–3.3). Conclusion: Using measures of genotype diversity, we showed that S. aureus NP carriage is highly dynamic in infants. Prolonged carriage with a single strain occurred rarely; persistent carriage was not observed. A correlation was observed between carrier index and genotype diversity.

Published
2019
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49. Persistent Malaria Transmission from Asymptomatic Children Despite Highly Effective Malaria Control in Eastern Uganda

Author

Andolina, Chiara, primary, Rek, John, additional, Briggs, Jessica, additional, Okoth, Joseph, additional, Musiime, Alex, additional, Ramjith, Jordache, additional, Teyssier, Noam, additional, Conrad, Melissa, additional, Nankabirwa, Joaniter I., additional, Lanke, Kjerstin, additional, Rodriguez-Barraquer, Isabel, additional, Meerstein-Kessel, Lisette, additional, Olwoch, Peter, additional, Rosenthal, Philip J., additional, Kamya, Moses, additional, Dorsey, Grant, additional, Greenhouse, Bryan, additional, Drakeley, Chris, additional, Staedke, Sarah, additional, and Bousema, Teun, additional

Published
2020
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