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Background Urinary incontinence often occurs in women aged 40-60 years and contributes to a significant impact on women's physical health and quality of life. Objective To explore the prevalence and influencing factors of urinary incontinence and its impact on quality of life in women aged 40-60 years in Guizhou Province. Methods From June 2022 to January 2023, women aged 40-60 years who underwent health checkups in 10 hospitals in 7 regions of Guizhou Province were selected as the study subjects. A self-designed general data questionnaire was used to collect the basic data of the study subjects, and International Consultation on Incontinence Questionnaire-Female Lower Urinary Tract Symptoms (ICIQ-FLUTS) and Incontinence Quality of Life Measure (I-QoL) were used to determine the severity of urinary incontinence and the level of quality of life of the study subjects, respectively. Different types of incontinence, including stress incontinence, urge incontinence, and mixed incontinence, were determined according to the diagnostic criteria established by the International Continence Society (ICS). Multivariate Logistic regression analysis was used to explore the influencing factors of urinary incontinence, and explore the effects of different types and severity levels of urinary incontinence on patients' quality of life. Results A total of 3 000 questionnaires were distributed, and 2 966 valid questionnaires were collected, with a valid recovery rate of 98.9%. The prevalence of urinary incontinence among the 2 966 study subjects was 33.4% (991/2 966), including 20.1% (596/2 966) for stress incontinence, 2.0% (58/2 966) for urge incontinence, and 11.4% (337/2 966) for mixed incontinence. Multivariate Logistic regression analysis showed that physical exercise, menstrual status, parity, history of pelvic organ prolapse, perineal laceration, and lateral episiotomy were the influencing factors of stress incontinence (P

Background Carotid plaque is an important early predictive signal of clinical carotid atherosclerosis, the association between homocysteine (Hcy) and carotid plaque is well recognized, however, the correlation between Hcy and carotid plaque in postmenopausal middle-aged women is not established. Objective To analyze the impact of Hcy within the normal reference range on the risk of carotid plaque in postmenopausal middle-aged women and determine the risk threshold. Methods A total of 1 465 postmenopausal women (Hcy

Background The associations of muscle and adipose tissue with bone mineral density (BMD) in perimenopausal women has been studied, but there are differences in site distribution, which lead to that the effect of muscle and adipose tissue on BMD and the site of action are still unclear. Objective To analyze the relationships of BMD in lumbar spine, femoral neck, total hip and adipose, muscle tissue in perimenopausal women, and provide theoretical basis for improving the quality of life of middle-aged and elderly and preventing and treatment of osteoporosis (OP) . Methods 2 355 women aged 40-60 years who underwent medical examination in the Health Management Center, Affiliated Hospital of Guizhou Medical University from January 2018 to October 2021 were retrospectively selected and divided into pre-menopausal women (n=1 261) and post-menopausal women (n=1 094) according to whether they were menopausal or not. BMD of lumbar spine, femoral neck, and total hip were measured by Dual energy X-ray Absorptiometry (DXA) . Adipose and muscle tissue were measured by Bioelectrical Impedance Analysis (BIA) . To explore the association of adipose and muscle tissue with BMD of different site in perimenopausal women by Pearson correlation and multiple linear regression analysis. Receiver operating characteristic (ROC) curve was used to analyze the predictive value of appendicular lean mass (ALM) for postmenopausal OP. Results Pearson correlation analysis showed that adipose mass, total body muscle mass, trunk muscle mass and ALM were positively correlated with BMD of lumbar spine, femoral neck and total hip in premenopausal, postmenopausal and overall women (P

This study describes and implements an integrated, multimedia, process-based system-level approach to estimating nitrogen (N) fate and transport in large river basins. The modeling system includes the following components: 1) Community Multi-Scale Air Quality (CMAQ); 2) Water Research and Forecasting (WRF); 3) Environmental Policy Integrated Climate (EPIC); and 4) Soil and Water Assessment Tool (SWAT). The previously developed Fertilizer Emission Scenario Tool for the Community Multiscale Air Quality (FEST-C) system integrated EPIC with the WRF model and CMAQ. FEST-C, driven by process-based WRF weather simulations, includes atmospheric N additions to agricultural cropland, and agricultural cropland contributions to ammonia emissions. Watershed hydrology and water quality models need to be integrated with the system (FEST-C), however, so it can be used in large river basins to address impacts of fertilization, meteorology, and atmospheric N deposition on water quality. Objectives of this paper are to describe how to expand the previous effort by integrating a watershed model with the FEST-C (CMAQ/WRF/EPIC) modeling system, as well as demonstrate application of the Integrated Modeling System (IMS) to the Mississippi River Basin (MRB) to simulate streamflow and dissolved N loadings to the Gulf of Mexico (GOM). IMS simulation results generally agree with USGS observations/estimations; the annual simulated streamflow is 218.9 mm and USGS observation is 211.1 mm and the annual simulated dissolved N is 2.1 kg/ha. and the USGS estimation is 2.8 kg/ha. Integrating SWAT with the CMAQ/WRF/EPIC modeling system allows for its use within large river basins without losing EPIC’s more detailed biogeochemistry processes, which will strengthen assessment of impacts of future climate scenarios, regulatory and voluntary programs for nitrogen oxide air emissions, and land use and land management on N transport and transformation in large river basins. [ABSTRACT FROM AUTHOR]