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Tracheomalacia is excessive trachea collapse, usually upon expiration. Severe symptoms accompany congenital types. Often milder versions occur following the neonatal period. Adult malacia is mostly linked to pulmonary chronic obstruction. There's still no standardized functional bronchoscopy. Dynamic CT airway is an excellent diagnostic tool. Bronchoscopy and stent insertion led to a major improvement, although with a high incidence of complication. Surgical lateropexia, excision of trachea and external surgical stabilization are possibilities. Aortopexy is the most common operation in children.

We identified the anti-Mullerian hormone (also known as Müllerian inhibiting substance or MIS) as an inhibitory hormone that induces long-term contraception in mammals. The type II receptor to this hormone, AMHR2 (also known as MISR2), represents a promising druggable target for the modulation of female reproduction with a mechanism of action distinct from steroidal contraceptives. We designed an in vitro platform to screen and validate small molecules that can activate MISR2 signaling and suppress ovarian folliculogenesis. Using a bone morphogenesis protein (BMP)–response element luciferase reporter cell–based assay, we screened 5,440 compounds from a repurposed drug library. Positive hits in this screen were tested for specificity and potency in luciferase dose–response assays, and biological activity was tested in ex vivo Mullerian duct regression bioassays. Selected candidates were further evaluated in ex vivo follicle/ovary culture assays and in vivo in mice and rats. Here, we report that SP600125, CYC-116, gandotinib, and ruxolitinib can specifically inhibit primordial follicle activation and repress folliculogenesis by stimulating the MISR2 pathway.