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493 results on '"Rancati, Tiziana"'

1. A Computational Model of the Tumor Microenvironment Applied to Fractionated Radiotherapy

Author

Possenti, Luca, Gallo, Andrea, Vitullo, Piermario, Cicchetti, Alessandro, Rancati, Tiziana, Costantino, Maria Laura, Zunino, Paolo, Castro, Carlos, Editor-in-Chief, Formaggia, Luca, Editor-in-Chief, Groppi, Maria, Series Editor, Larson, Mats G., Series Editor, Lopez Fernandez, Maria, Series Editor, Morales de Luna, Tomás, Series Editor, Pareschi, Lorenzo, Series Editor, Vázquez-Cendón, Elena, Series Editor, Zunino, Paolo, Series Editor, Linninger, Andreas, editor, and Mardal, Kent-Andre, editor

Published
2024
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3. Comparison of outcomes of different biopsy schedules among men on active surveillance for prostate cancer: An analysis of the G.A.P.3 global consortium database

Author

Beckmann, Kerri R, Bangma, Chris H, Helleman, Jozien, Bjartell, Anders, Carroll, Peter R, Morgan, Todd, Nieboer, Daan, Santaolalla, Aida, Trock, Bruce J, Valdagni, Riccardo, Roobol, Monique J, Trock, Bruce, Ehdaie, Behfar, Carroll, Peter, Filson, Christopher, Logothetis, Christopher, Klotz, Laurence, Pickles, Tom, Hyndman, Eric, Moore, Caroline, Gnanapragasam, Vincent, Van Hemelrijck, Mieke, Dasgupta, Prokar, Bangma, Chris, Roobol, Monique, Villers, Arnauld, Robert, Grégoire, Semjonow, Axel, Rannikko, Antti, Perry, Antoinette, Hugosson, Jonas, Rubio‐Briones, Jose, Hefermehl, Lukas, Shiong, Lee Lui, Frydenberg, Mark, Stricker, Phillip, Sugimoto, Mikio, Chung, Byung Ha, van der Kwast, Theo, van der Linden, Wim, Hulsen, Tim, Ruwe, Boris, van Hooft, Peter, Steyerberg, Ewout, Beckmann, Kerri, Denton, Brian, Hayen, Andrew, Boutros, Paul, Guo, Wei, Benfante, Nicole, Cowan, Janet, Patil, Dattatraya, Park, Lauren, Ferrante, Stephanie, Mamedov, Alexandre, LaPointe, Vincent, Crump, Trafford, Stavrinides, Vasilis, Kimberly‐Duffell, Jenna, Olivier, Jonathan, Rancati, Tiziana, Ahlgren, Helén, Mascarós, Juanma, Löfgren, Annica, Lehmann, Kurt, Lin, Catherine Han, Cusick, Thomas, Hirama, Hiromi, Lee, Kwang Suk, Jenster, Guido, Auvinen, Anssi, Haider, Masoom, van Bochove, Kees, Kouspou, Michelle, and Paich, Kellie

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Urologic Diseases, Aging, Prevention, Cancer, Prostate Cancer, Clinical Research, Biopsy, Disease Progression, Humans, Male, Neoplasm Grading, Prostate, Prostate-Specific Antigen, Prostatic Neoplasms, Watchful Waiting, active surveillance, biopsy schedule, prostate cancer, treatment, upgrading, Global Action Plan Active Surveillance Prostate Cancer [G.A.P.3] Consortium, Paediatrics and Reproductive Medicine, Oncology & Carcinogenesis, Clinical sciences, Oncology and carcinogenesis
Abstract

BackgroundThe optimal interval for repeat biopsy during active surveillance (AS) for prostate cancer is yet to be defined. This study examined whether risk of upgrading (to grade group ≥ 2) or risk of converting to treatment varied according to intensity of repeat biopsy using data from the GAP3 consortium's global AS database.Materials and methodsIntensity of surveillance biopsy schedules was categorized according to centers' protocols: (a) Prostate Cancer Research International Active Surveillance project (PRIAS) protocols with biopsies at years 1, 4, and 7 (10 centers; 7532 men); (b) biennial biopsies, that is, every other year (8 centers; 4365 men); and (c) annual biopsy schedules (4 centers; 1602 men). Multivariable Cox regression was used to compare outcomes according to biopsy intensity.ResultsOut of the 13,508 eligible participants, 56% were managed according to PRIAS protocols (biopsies at years 1, 4, and 7), 32% via biennial biopsy, and 12% via annual biopsy. After adjusting for baseline characteristics, risk of converting to treatment was greater for those on annual compared with PRIAS biopsy schedules (hazard ratio [HR] = 1.66; 95% confidence interval [CI] = 1.51-1.83; p

Published
2022

6. Pelvic bone marrow dose-volume predictors of late lymphopenia following pelvic lymph node radiation therapy for prostate cancer

Author

Pavarini, Maddalena, Alborghetti, Lisa, Aimonetto, Stefania, Maggio, Angelo, Landoni, Valeria, Ferrari, Paolo, Bianculli, Antonella, Petrucci, Edoardo, Cicchetti, Alessandro, Farina, Bruno, Ubeira-Gabellini, Maria Giulia, Salmoiraghi, Paolo, Moretti, Eugenia, Avuzzi, Barbara, Giandini, Tommaso, Munoz, Fernando, Magli, Alessandro, Sanguineti, Giuseppe, Magdalena Waskiewicz, Justyna, Rago, Luciana, Cante, Domenico, Girelli, Giuseppe, Vavassori, Vittorio, Di Muzio, Nadia Gisella, Rancati, Tiziana, Cozzarini, Cesare, and Fiorino, Claudio

Published
2024
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11. Worsening of 2-year patient-reported intestinal functionality after radiotherapy for prostate cancer including pelvic node irradiation

Author

Sanguineti, Giuseppe, Pavarini, Maddalena, Munoz, Fernando, Magli, Alessandro, Cante, Domenico, Garibaldi, Elisabetta, Gebbia, Andrea, Noris Chiorda, Barbara, Girelli, Giuseppe, Villa, Elisa, Faiella, Adriana, Magdalena Waskiewicz, Justyna, Avuzzi, Barbara, Pastorino, Alice, Moretti, Eugenia, Rago, Luciana, Statuto, Teodora, Gatti, Marco, Rancati, Tiziana, Valdagni, Riccardo, Luigi Vavassori, Vittorio, Gisella Di Muzio, Nadia, Fiorino, Claudio, and Cozzarini, Cesare

Published
2024
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12. Prostate Cancer Patients Under Active Surveillance with a Suspicious Magnetic Resonance Imaging Finding Are at Increased Risk of Needing Treatment: Results of the Movember Foundation’s Global Action Plan Prostate Cancer Active Surveillance (GAP3) Consortium

Author

Olivier, Jonathan, Li, Weiyu, Nieboer, Daan, Helleman, Jozien, Roobol, Monique, Gnanapragasam, Vincent, Frydenberg, Mark, Sugimoto, Mikio, Carroll, Peter, Morgan, Todd M, Valdagni, Riccardo, Rubio-Briones, Jose, Robert, Grégoire, Stricker, Phillip, Hayen, Andrew, Schoots, Ivo, Haider, Masoom, Moore, Caroline M, Denton, Brian, Villers, Arnauld, Trock, Bruce, Ehdaie, Behfar, Filson, Christopher, Logothetis, Christopher, Morgan, Todd, Klotz, Laurence, Pickles, Tom, Hyndman, Eric, Van Hemelrijck, Mieke, Dasgupta, Prokar, Bangma, Chris, Semjonow, Axel, Rannikko, Antti, Perry, Antoinette, Hugosson, Jonas, Bjartell, Anders, Hefermehl, Lukas, Shiong, Lee Lui, Chung, Byung Ha, van der Kwast, Theo, Hulsen, Tim, van der Linden, Wim, Ruwe, Boris, van Hooft, Peter, Steyerberg, Ewout, Boutros, Paul, Guo, Wei, Benfante, Nicole, Cowan, Janet, Patil, Dattatraya, Park, Lauren, Ferrante, Stephanie, Mamedov, Alexandre, LaPointe, Vincent, Crump, Trafford, Stavrinides, Vasilis, Kimberly-Duffell, Jenna, Santaolalla, Aida, Rancati, Tiziana, Ahlgren, Helén, Mascarós, Juanma, Löfgren, Annica, Lehmann, Kurt, Lin, Catherine Han, Cusick, Thomas, Hirama, Hiromi, Lee, Kwang Suk, Jenster, Guido, Auvinen, Anssi, van Bochove, Kees, Kouspou, Michelle, and Paich, Kellie

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Prevention, Clinical Research, Biomedical Imaging, Clinical Trials and Supportive Activities, Aging, Cancer, Urologic Diseases, Prostate Cancer, Detection, screening and diagnosis, 4.2 Evaluation of markers and technologies, Magnetic resonance imaging, Prostate cancer, Active surveillance, Discontinuation, Worldwide, Nomogram, Movember Foundation's Global Action Plan Prostate Cancer Active Surveillance GAP3 Consortium, Urology & Nephrology, Clinical sciences
Abstract

BackgroundThe inclusion criterion for active surveillance (AS) is low- or intermediate-risk prostate cancer. The predictive value of the presence of a suspicious lesion at magnetic resonance imaging (MRI) at the time of inclusion is insufficiently known.ObjectiveTo evaluate the percentage of patients needing active treatment stratified by the presence or absence of a suspicious lesion at baseline MRI.Design setting and participantsA retrospective analysis of the data from the multicentric AS GAP3 Consortium database was conducted. The inclusion criteria were men with grade group (GG) 1 or GG 2 prostate cancer combined with prostate-specific antigen

Published
2022

13. Contouring variation affects estimates of normal tissue complication probability for breast fibrosis after radiotherapy

Author

Jaikuna, Tanwiwat, Osorio, Eliana Vasquez, Azria, David, Chang-Claude, Jenny, De Santis, Maria Carmen, Gutiérrez-Enríquez, Sara, van Herk, Marcel, Hoskin, Peter, Lambrecht, Maarten, Lingard, Zoe, Seibold, Petra, Seoane, Alejandro, Sperk, Elena, Symonds, R Paul, Talbot, Christopher J., Rancati, Tiziana, Rattay, Tim, Reyes, Victoria, Rosenstein, Barry S., de Ruysscher, Dirk, Vega, Ana, Veldeman, Liv, Webb, Adam, West, Catharine M.L., and Aznar, Marianne C.

Published
2023
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16. Genome-wide association study of treatment-related toxicity two years following radiotherapy for breast cancer

Author

Jandu, Harkeran K., Veal, Colin D., Fachal, Laura, Luccarini, Craig, Aguado-Barrera, Miguel E., Altabas, Manuel, Azria, David, Baten, Adinda, Bourgier, Celine, Bultijnck, Renée, Colciago, Riccardo R., Farcy-Jacquet, Marie-Pierre, Chang-Claude, Jenny, Choudhury, Ananya, Dunning, Alison, Elliott, Rebecca M., Green, Sheryl, Gutiérrez-Enríquez, Sara, Herskind, Carsten, Lambrecht, Maarten, Monten, Christel, Rancati, Tiziana, Reyes, Victoria, Rosenstein, Barry S., De Ruysscher, Dirk, Carmen De Santis, Maria, Seibold, Petra, Sperk, Elena, Veldwijk, Marlon, Paul Symonds, R., Stobart, Hilary, Taboada-Valladares, Begoña, Vega, Ana, Veldeman, Liv, Webb, Adam J., Weltens, Caroline, West, Catharine M., Rattay, Tim, and Talbot, Christopher J.

Published
2023
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17. Validation of prediction models for radiation-induced late rectal bleeding: Evidence from a large pooled population of prostate cancer patients

Author

Cicchetti, Alessandro, Fiorino, Claudio, Ebert, Martin A., Iacovacci, Jacopo, Kennedy, Angel, Joseph, David J., Denham, James W., Vavassori, Vittorio, Fellin, Gianni, Cozzarini, Cesare, Esposti, Claudio Degli, Gabriele, Pietro, Munoz, Fernando, Avuzzi, Barbara, Valdagni, Riccardo, and Rancati, Tiziana

Published
2023
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19. Quality of Life Longitudinal Evaluation in Prostate Cancer Patients from Radiotherapy Start to 5 Years after IMRT-IGRT

Author

Maggio, Angelo, primary, Rancati, Tiziana, additional, Gatti, Marco, additional, Cante, Domenico, additional, Avuzzi, Barbara, additional, Bianconi, Cinzia, additional, Badenchini, Fabio, additional, Farina, Bruno, additional, Ferrari, Paolo, additional, Giandini, Tommaso, additional, Girelli, Giuseppe, additional, Landoni, Valeria, additional, Magli, Alessandro, additional, Moretti, Eugenia, additional, Petrucci, Edoardo, additional, Salmoiraghi, Paolo, additional, Sanguineti, Giuseppe, additional, Villa, Elisa, additional, Waskiewicz, Justyna Magdalena, additional, Guarneri, Alessia, additional, Valdagni, Riccardo, additional, Fiorino, Claudio, additional, and Cozzarini, Cesare, additional

Published
2024
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20. Reasons for Discontinuing Active Surveillance: Assessment of 21 Centres in 12 Countries in the Movember GAP3 Consortium

Author

Van Hemelrijck, Mieke, Ji, Xi, Helleman, Jozien, Roobol, Monique J, van der Linden, Wim, Nieboer, Daan, Bangma, Chris H, Frydenberg, Mark, Rannikko, Antti, Lee, Lui S, Gnanapragasam, Vincent J, Kattan, Mike W, Trock, Bruce, Ehdaie, Behfar, Carroll, Peter, Filson, Christopher, Kim, Jeri, Logothetis, Christopher, Morgan, Todd, Klotz, Laurence, Pickles, Tom, Hyndman, Eric, Moore, Caroline M, Gnanapragasam, Vincent, Dasgupta, Prokar, Bangma, Chris, Roobol, Monique, Villers, Arnauld, Valdagni, Riccardo, Perry, Antoinette, Hugosson, Jonas, Rubio-Briones, Jose, Bjartell, Anders, Hefermehl, Lukas, Shiong, Lee Lui, Kakehi, Yoshiyuki, Chung, Byung Ha, van der Kwast, Theo, Obbink, Henk, Hulsen, Tim, de Jonge, Cees, Kattan, Mike, Xinge, Ji, Muir, Kenneth, Lophatananon, Artitaya, Fahey, Michael, Steyerberg, Ewout, Zhang, Liying, Santa Olalla, Aida, Beckmann, Kerri, Denton, Brian, Hayen, Andrew, Boutros, Paul, Guo, Wei, Benfante, Nicole, Cowan, Janet, Patil, Dattatraya, Tolosa, Emily, Kim, Tae-Kyung, Mamedov, Alexandre, La Pointe, Vincent, Crump, Trafford, Kimberly-Duffell, Jenna, Santaolalla, Aida, Olivier, Jonathan, Rancati, Tiziana, Ahlgren, Helén, Mascarós, Juanma, Löfgren, Annica, Lehmann, Kurt, Lin, Catherine Han, Hirama, Hiromi, Lee, Kwang Suk, Jenster, Guido, Auvinen, Anssi, Haider, Masoom, van Bochove, Kees, Carter, Ballentine, Gledhill, Sam, Buzza, Mark, and Bruinsma, Sophie

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Prostate Cancer, Aging, Prevention, Urologic Diseases, Cancer, Good Health and Well Being, Aged, Asia, Australia, Biopsy, Cause of Death, Clinical Decision-Making, Databases, Factual, Disease Progression, Early Detection of Cancer, Europe, Humans, Kallikreins, Male, Middle Aged, North America, Patient Dropouts, Predictive Value of Tests, Prostate-Specific Antigen, Prostatic Neoplasms, Risk Assessment, Risk Factors, Time Factors, Watchful Waiting, Prostate cancer, Active surveillance, Discontinuation, Worldwide, Members of the Movember Foundation's Global Action Plan Prostate Cancer Active Surveillance GAP3 consortium, Urology & Nephrology, Clinical sciences
Abstract

BackgroundCareful assessment of the reasons for discontinuation of active surveillance (AS) is required for men with prostate cancer (PCa).ObjectiveUsing Movember's Global Action Plan Prostate Cancer Active Surveillance initiative (GAP3) database, we report on reasons for AS discontinuation.Design, setting, and participantsWe compared data from 10296 men on AS from 21 centres across 12 countries.Outcome measurements and statistical analysisCumulative incidence methods were used to estimate the cumulative incidence rates of AS discontinuation.Results and limitationsDuring 5-yr follow-up, 27.5% (95% confidence interval [CI]: 26.4-28.6%) men showed signs of disease progression, 12.8% (95% CI: 12.0-13.6%) converted to active treatment without evidence of progression, 1.7% (95% CI: 1.5-2.0%) continued to watchful waiting, and 1.7% (95% CI: 1.4-2.1%) died from other causes. Of the 7049 men who remained on AS, 2339 had follow-up for >5yr, 4561 had follow-up for

Published
2019

21. Active Surveillance for Men Younger than 60 Years or with Intermediate-risk Localized Prostate Cancer. Descriptive Analyses of Clinical Practice in the Movember GAP3 Initiative

Author

Trock, Bruce, Ehdaie, Behfar, Carroll, Peter, Filson, Christopher, Logothetis, Christopher, Morgan, Todd, Klotz, Laurence, Pickles, Tom, Hyndman, Eric, Moore, Caroline, Gnanapragasam, Vincent, Van Hemelrijck, Mieke, Dasgupta, Prokar, Bangma, Chris, Roobol, Monique, Villers, Arnauld, Robert, Grégoire, Semjonow, Axel, Rannikko, Antti, Valdagni, Riccardo, Perry, Antoinette, Hugosson, Jonas, Rubio-Briones, Jose, Bjartell, Anders, Hefermehl, Lukas, Lui Shiong, Lee, Frydenberg, Mark, Stricker, Phillip, Sugimoto, Mikio, Ha Chung, Byung, van der Kwast, Theo, van der Linden, Wim, Hulsen, Tim, Ruwe, Boris, Peter van Hooft, Steyerberg, Ewout, Nieboer, Daan, Beckmann, Kerri, Denton, Brian, Hayen, Andrew, Boutros, Paul, Guo, Wei, Benfante, Nicole, Cowan, Janet, Patil, Dattatraya, Park, Lauren, Ferrante, Stephanie, Mamedov, Alexandre, LaPointe, Vincent, Crump, Trafford, Stavrinides, Vasilis, Kimberly-Duffell, Jenna, Santaolalla, Aida, Olivier, Jonathan, Rancati, Tiziana, Ahlgren, Helén, Mascarós, Juanma, Löfgren, Annica, Lehmann, Kurt, Han Lin, Catherine, Cusick, Thomas, Hirama, Hiromi, Suk Lee, Kwang, Jenster, Guido, Auvinen, Anssi, Haider, Masoom, van Bochove, Kees, Kouspou, Michelle, Paich, Kellie, Helleman, Jozien, Remmers, Sebastiaan, Hyndman, Matthew E., Moore, Caroline M., Shiong Lee, Lui, Elhage, Oussama, Morgan, Todd M., Bangma, Chris H., and Roobol, Monique J.

Published
2022
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22. Overview of health-related quality of life and toxicity of non-small cell lung cancer patients receiving curative-intent radiotherapy in a real-life setting (the REQUITE study)

Author

Van der Weijst, Lotte, Aguado-Barrera, Miguel E., Azria, David, Berkovic, Patrick, Boisselier, Pierre, Briers, Erik, Bultijnck, Renée, Calvo-Crespo, Patricia, Chang-Claude, Jenny, Choudhury, Ananya, Defraene, Gilles, Demontois, Sylvian, Dunning, Alison M., Elliott, Rebecca M., Ennis, Dawn, Faivre-Finn, Corinne, Franceschini, Marzia, Gutiérrez-Enríquez, Sara, Herskind, Carsten, Higginson, Daniel S., Kerns, Sarah L., Johnson, Kerstie, Mollà, Meritxell, Lambrecht, Maarten, Ramos, Mónica, Rancati, Tiziana, Rimner, Andreas, Rosenstein, Barry S., De Ruysscher, Dirk, Salem, Ahmed, Sangalli, Claudia, Seibold, Petra, Sosa-Fajardo, Paloma, Sperk, Elena, Stobart, Hilary, Summersgill, Holly, Surmont, Veerle, Symonds, Paul, Taboada-Lorenzo, Begoña, Talbot, Christopher J., Valdagni, Riccardo, Vega, Ana, Veldeman, Liv, Veldwijk, Marlon R., Ward, Tim, Webb, Adam, West, Catharine M.L., and Lievens, Yolande

Published
2022
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23. Use of angiotensin converting enzyme inhibitors is associated with reduced risk of late bladder toxicity following radiotherapy for prostate cancer

Author

Azria, David, Briers, Erik, Chang-Claude, Jenny, Choudhury, Ananya, Dunning, Alison, Elliott, Rebecca M, Gutiérrez-Enríquez, Sara, Rancati, Tiziana, Rattay, Tim, Rosenstein, Barry S., De Ruysscher, Dirk, Seibold, Petra, Sperk, Elena, Paul Symonds, R, Stobart, Hilary, Talbot, Christopher J., Vega, Ana, Veldeman, Liv, Ward, Tim, Webb, Adam, West, Catharine M., Kerns, Sarah L., Amidon Morlang, Ashley, Lee, Sharon M., Peterson, Derick R., Marples, Brian, Zhang, Hong, Bylund, Kevin, Rosenzweig, Doug, Hall, William, De Ruyck, Kim, Stock, Richard G., Gómez-Caamaño, Antonio, Sosa-Fajardo, Paloma, Taboada-Valladares, Begoña, Aguado-Barrera, Miguel E., Parker, Chris, Fonteyne, Valérie, Bultijnck, Renée, Symonds, R. Paul, Johnson, Kerstie, Lambrecht, Maarten, de Ruysscher, Dirk, Vanneste, Ben, Elliott, Rebecca M., Herskind, Carsten, Veldwijk, Marlon R., Avuzzi, Barbara, Valdagni, Riccardo, Farcy Jacquet, Marie-Pierre, West, Catharine, Janelsins, Michelle, Chen, Yuhchyau, Messing, Edward, and Morrow, Gary

Published
2022
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25. Prostate Cancer Patients Under Active Surveillance with a Suspicious Magnetic Resonance Imaging Finding Are at Increased Risk of Needing Treatment: Results of the Movember Foundation’s Global Action Plan Prostate Cancer Active Surveillance (GAP3) Consortium

Author

Trock, Bruce, Ehdaie, Behfar, Carroll, Peter, Filson, Christopher, Logothetis, Christopher, Morgan, Todd, Klotz, Laurence, Pickles, Tom, Hyndman, Eric, Moore, Caroline M, Gnanapragasam, Vincent, Van Hemelrijck, Mieke, Dasgupta, Prokar, Bangma, Chris, Roobol, Monique, Villers, Arnauld, Robert, Grégoire, Semjonow, Axel, Rannikko, Antti, Valdagni, Riccardo, Perry, Antoinette, Hugosson, Jonas, Rubio-Briones, Jose, Bjartell, Anders, Hefermehl, Lukas, Lui Shiong, Lee, Frydenberg, Mark, Stricker, Phillip, Sugimoto, Mikio, Ha Chung, Byung, van der Kwast, Theo, Hulsen, Tim, van der Linden, Wim, Ruwe, Boris, van Hooft, Peter, Steyerberg, Ewout, Nieboer, Daan, Denton, Brian, Hayen, Andrew, Boutros, Paul, Guo, Wei, Benfante, Nicole, Cowan, Janet, Patil, Dattatraya, Park, Lauren, Ferrante, Stephanie, Mamedov, Alexandre, LaPointe, Vincent, Crump, Trafford, Stavrinides, Vasilis, Kimberly-Duffell, Jenna, Santaolalla, Aida, Olivier, Jonathan, Rancati, Tiziana, Ahlgren, Helén, Mascarós, Juanma, Löfgren, Annica, Lehmann, Kurt, Han Lin, Catherine, Cusick, Thomas, Hirama, Hiromi, Suk Lee, Kwang, Jenster, Guido, Auvinen, Anssi, Haider, Masoom, van Bochove, Kees, Kouspou, Michelle, Paich, Kellie, Helleman, Jozien, Li, Weiyu, Morgan, Todd M., Schoots, Ivo, and Moore, Caroline M.

Published
2022
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27. Comparison of Characteristics, Follow-up and Outcomes of Active Surveillance for Prostate Cancer According to Ethnicity in the GAP3 Global Consortium Database

Author

Trock, Bruce, Ehdaie, Behfar, Carroll, Peter, Filson, Christopher, Logothetis, Christopher, Morgan, Todd, Klotz, Laurence, Pickles, Tom, Hyndman, Eric, Moore, Caroline, Gnanapragasam, Vincent, Van Hemelrijck, Mieke, Dasgupta, Prokar, Bangma, Chris, Roobol, Monique, Villers, Arnauld, Robert, Grégoire, Semjonow, Axel, Rannikko, Antti, Valdagni, Riccardo, Perry, Antoinette, Hugosson, Jonas, Rubio-Briones, Jose, Bjartell, Anders, Hefermehl, Lukas, Lui Shiong, Lee, Frydenberg, Mark, Stricker, Phillip, Sugimoto, Mikio, Ha Chung, Byung, van der Kwast, Theo, van der Linden, Wim, Hulsen, Tim, Ruwe, Boris, van Hooft, Peter, Steyerberg, Ewout, Nieboer, Daan, Beckmann, Kerri, Denton, Brian, Hayen, Andrew, Boutros, Paul, Guo, Wei, Benfante, Nicole, Cowan, Janet, Patil, Dattatraya, Park, Lauren, Ferrante, Stephanie, Mamedov, Alexandre, LaPointe, Vincent, Crump, Trafford, Stavrinides, Vasilis, Kimberly-Duffell, Jenna, Santaolalla, Aida, Olivier, Jonathan, Rancati, Tiziana, Ahlgren, Helén, Mascarós, Juanma, Löfgren, Annica, Lehmann, Kurt, Han Lin, Catherine, Cusick, Thomas, Hirama, Hiromi, Suk Lee, Kwang, Jenster, Guido, Auvinen, Anssi, Haider, Masoom, van Bochove, Kees, Kouspou, Michelle, Paich, Kellie, Helleman, Jozien, Shiong Lee, Lui, and Elhage, Oussama

Published
2021
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28. Knowledge-Based Plan Prediction Modelling of Whole Breast Irradiation: An International Inter-Consortium Experience

Author

Placidi, Lorenzo, primary, Griffin, Peter, additional, Castriconi, Roberta, additional, Tudda, Alessia, additional, Becchi, Giovanna, additional, Burns, Mark, additional, Cagni, Elisabetta, additional, Markham, Cathy, additional, Landoni, Valeria, additional, Moretti, Eugenia, additional, Oliviero, Caterina, additional, Rambaldi Guidasci, Giulia, additional, Meffe, Guenda, additional, rancati, tiziana, additional, Scaggion, Alessandro, additional, McGoldrick, Karen, additional, Panettieri, Vanessa, additional, and Fiorino, Claudio, additional

Published
2024
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29. Optimising Inter-Patient Image Registration for Image-Based Data Mining in Breast Radiotherapy

Author

Jaikuna, Tanwiwat, primary, Wilson, Fiona, additional, Azria, David, additional, Chang-Claude, Jenny, additional, De Santis, Maria Carmen, additional, Gutiérrez-Enríquez, Sara, additional, van Herk, Marcel, additional, Hoskin, Peter, additional, Kotzki, Lea, additional, Lambrecht, Maarten, additional, Seibold, Petra, additional, Seoane, Alejandro, additional, Sperk, Elena, additional, Symonds, R. Paul, additional, J Talbot, Christopher, additional, rancati, tiziana, additional, Rattay, Tim, additional, Reyes, Victoria, additional, Rosenstein, Barry S., additional, de Ruysscher, D., additional, Vega, Ana, additional, Veldeman, Liv, additional, Webb, Adam, additional, West, Catharine ML, additional, Aznar, Marianne Camille, additional, and Vasquez Osorio, Eliana, additional

Published
2024
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30. Fat Necrosis after One-Week Partial Breast Irradidation or Standard of Care: A Case-Control Study

Author

Colciago, Riccardo Ray, primary, La Rocca, Eliana, additional, Giandini, Carlotta, additional, Carnevale, Maria Grazia, additional, Bianchi, Giulia Valeria, additional, Maugeri, Ilaria, additional, Depretto, Catherine, additional, Meroni, Silvia, additional, Cavallo, Anna, additional, Pignoli, Emanuele, additional, Lozza, Laura, additional, rancati, tiziana, additional, and De Santis, Maria Carmen, additional

Published
2024
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33. Comparing Performances of Predictive Models of Toxicity after Radiotherapy for Breast Cancer Using Different Machine Learning Approaches.

Author

Ubeira-Gabellini, Maria Giulia, Mori, Martina, Palazzo, Gabriele, Cicchetti, Alessandro, Mangili, Paola, Pavarini, Maddalena, Rancati, Tiziana, Fodor, Andrei, del Vecchio, Antonella, Di Muzio, Nadia Gisella, and Fiorino, Claudio

Subjects
PREDICTIVE tests, DATABASE management, DATA analysis, RECEIVER operating characteristic curves, RESEARCH funding, RADIATION injuries, BREAST tumors, LOGISTIC regression analysis, TREATMENT effectiveness, RADIATION dosimetry, DESCRIPTIVE statistics, STATISTICS, MACHINE learning
Abstract

Simple Summary: Studies comparing performances of machine learning (ML) methods in building predictive models of toxicity in RT are rare. Thanks to the availability of a large cohort (n = 1314) of breast cancer patients homogeneously treated with tangential fields, different ML approaches could be compared. This work shows how more complex models typically achieve higher performances. At the same time, for this test case, the importance is given mainly by a few variables, and toxicity can be predicted by simpler models with similar performances. The availability of more individually characterizing features (here partially missing) is expected to have a likely much higher impact than the choice of the best-performing ML/DL approach. Purpose. Different ML models were compared to predict toxicity in RT on a large cohort (n = 1314). Methods. The endpoint was RTOG G2/G3 acute toxicity, resulting in 204/1314 patients with the event. The dataset, including 25 clinical, anatomical, and dosimetric features, was split into 984 for training and 330 for internal tests. The dataset was standardized; features with a high p-value at univariate LR and with Spearman ρ > 0.8 were excluded; synthesized data of the minority were generated to compensate for class imbalance. Twelve ML methods were considered. Model optimization and sequential backward selection were run to choose the best models with a parsimonious feature number. Finally, feature importance was derived for every model. Results. The model's performance was compared on a training–test dataset over different metrics: the best performance model was LightGBM. Logistic regression with three variables (LR3) selected via bootstrapping showed performances similar to the best-performing models. The AUC of test data is slightly above 0.65 for the best models (highest value: 0.662 with LightGBM). Conclusions. No model performed the best for all metrics: more complex ML models had better performances; however, models with just three features showed performances comparable to the best models using many (n = 13–19) features. [ABSTRACT FROM AUTHOR]

Published
2024
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35. Adherence to Active Surveillance Protocols for Low-risk Prostate Cancer: Results of the Movember Foundation’s Global Action Plan Prostate Cancer Active Surveillance Initiative

Author

Trock, Bruce, Ehdaie, Behfar, Carroll, Peter, Filson, Christopher, Kim, Jeri, Logothetis, Christopher, Morgan, Todd, Klotz, Laurence, Pickles, Tom, Hyndman, Eric, Moore, Caroline M., Gnanapragasam, Vincent, Van Hemelrijck, Mieke, Dasgupta, Prokar, Bangma, Chris, Roobol, Monique, Villers, Arnauld, Rannikko, Antti, Valdagni, Riccardo, Perry, Antoinette, Hugosson, Jonas, Rubio-Briones, Jose, Bjartell, Anders, Hefermehl, Lukas, Shiong, Lee Lui, Frydenberg, Mark, Kakehi, Yoshiyuki, Chung, Byung Ha, van der Kwast, Theo, Obbink, Henk, van der Linden, Wim, Hulsen, Tim, Jonge, Cees de, Kattan, Mike, Xinge, Ji, Muir, Kenneth, Lophatananon, Artitaya, Fahey, Michael, Steyerberg, Ewout, Nieboer, Daan, Zhang, Liying, Beckmann, Kerri, Denton, Brian, Hayen, Andrew, Boutros, Paul, Guo, Wei, Benfante, Nicole, Cowan, Janet, Patil, Dattatraya, Tolosa, Emily, Kim, Tae-Kyung, Mamedov, Alexandre, LaPointe, Vincent, Crump, Trafford, Kimberly-Duffell, Jenna, Santaolalla, Aida, Olivier, Jonathan, Rancati, Tiziana, Ahlgren, Helén, Mascarós, Juanma, Löfgren, Annica, Lehmann, Kurt, Lin, Catherine Han, Hirama, Hiromi, Lee, Kwang Suk, Jenster, Guido, Auvinen, Anssi, Haider, Masoom, van Bochove, Kees, Carter, Ballentine, Gledhill, Sam, Buzza, Mark, Bruinsma, Sophie, Helleman, Jozien, Kalapara, Arveen A., Verbeek, Jan F.M., Lee, Lui Shiong, Bangma, Chris H., Steyerberg, Ewout W., Harkin, Tim, and Roobol, Monique J.

Published
2020
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36. Comparison of prone and supine positioning for breast cancer radiotherapy using REQUITE data: dosimetry, acute and two years physician and patient-reported outcomes

Author

Vakaet, Vincent, primary, Deseyne, Pieter, additional, Bultijnck, Renée, additional, Post, Giselle, additional, West, Catharine, additional, Azria, David, additional, Bourgier, Celine, additional, Farcy-Jacquet, Marie-Pierre, additional, Rosenstein, Barry, additional, Green, Sheryl, additional, de Ruysscher, Dirk, additional, Sperk, Elena, additional, Veldwijk, Marlon, additional, Herskind, Carsten, additional, De Santis, Maria Carmen, additional, Rancati, Tiziana, additional, Giandini, Tommaso, additional, Chang-Claude, Jenny, additional, Seibold, Petra, additional, Lambrecht, Maarten, additional, Weltens, Caroline, additional, Janssens, Hilde, additional, Vega, Ana, additional, Taboada-Valladares, Maria Begoña, additional, Aguado-Barrera, Miguel Elías, additional, Reyes, Victoria, additional, Altabas, Manuel, additional, Gutiérrez-Enríquez, Sara, additional, Monten, Christel, additional, Van Hulle, Hans, additional, and Veldeman, Liv, additional

Published
2023
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38. REQUITE: A prospective multicentre cohort study of patients undergoing radiotherapy for breast, lung or prostate cancer

Author

Lievens, Yolande, van Eijkeren, Marc, Vandecasteele, Katrien, Elhamin, Elhaseen, Ost, Piet, Fonteyne, Valérie, Swimberghe, Martijn, Deseyne, Pieter, De Neve, Wilfried, Duprez, Fréderic, Mareel, Marcus, Monten, Chris, Van Greveling, Annick, Vercauteren, Tom, Paelinck, Leen, Defraene, Gilles, Aerts, Rita, Arredouani, Soumia, Lambrecht, Maarten, Vanneste, Ben, Draghici, Roxana, Giordano, Frank, Herskind, Carsten, Veldwijk, Marlon, Helmbold, Irmgard, Giesche, Ulrich, Stegmaier, Petra, Weiß, Christian, Blaschke, Thomas, Neu, Burkhard, Lozza, Laura, Avuzzi, Barbara, Morlino, Sara, Sangalli, Claudia, Franceschini, Marzia, Rodriguez-Lage, Belina, Fernández-Tajes, Juan, Fuentes-Rios, Olivia, Domínguez-Rios, Isabel, Fajardo-Paneque, Irene, Sosa-Fajardo, Paloma, Torrado-Moya, Laura, Ramos-Albiac, Mónica, Giraldo, Alexandra, Altabas, Manolo, Piqué-Leiva, Bibiana, García-Relancio, David, Seoane-Ramallo, Alejandro, Lavers, Samuel, Wright, Simon, Dobbelaere, Hannah, Appleton, Donna, Kaushik, Monika, Kenny, Frances, Khout, Hazem, Krupa, Jaroslaw, Lambert, Kelly V., Pilgrim, Simon, Shokuhi, Sheila, Valassiadou, Kalliope, Aznar-Garcia, Luis, Boiangui, Ion, Kancherla, Kiran, Kent, Christopher, Sampson, Kufre, Osman, Ahmed, Sridhar, Thiagarajan, Vasanthan, Subramaniam, Faivre-Finn, Corinne, Harrop, Victoria, Keni, Manjusha, Foweraker, Karen, Pascoe, Abigail, Esler, Claire, Stock, Richard, Green, Sheryl, Golchin, Ava, Li, William, Seibold, Petra, Webb, Adam, Aguado-Barrera, Miguel E., Azria, David, Bourgier, Celine, Brengues, Muriel, Briers, Erik, Bultijnck, Renée, Calvo-Crespo, Patricia, Carballo, Ana, Choudhury, Ananya, Cicchetti, Alessandro, Claßen, Johannes, Delmastro, Elena, Dunning, Alison M., Elliott, Rebecca M., Fachal, Laura, Farcy-Jacquet, Marie-Pierre, Gabriele, Pietro, Garibaldi, Elisabetta, Gómez-Caamaño, Antonio, Gutiérrez-Enríquez, Sara, Higginson, Daniel S., Johnson, Kerstie, Lobato-Busto, Ramón, Mollà, Meritxell, Müller, Anusha, Payne, Debbie, Peleteiro, Paula, Post, Giselle, Rancati, Tiziana, Rattay, Tim, Reyes, Victoria, Rosenstein, Barry S., De Ruysscher, Dirk, De Santis, Maria Carmen, Schäfer, Jörg, Schnabel, Thomas, Sperk, Elena, Symonds, R. Paul, Stobart, Hilary, Taboada-Valladares, Begoña, Talbot, Christopher J., Valdagni, Riccardo, Vega, Ana, Veldeman, Liv, Ward, Tim, Weißenberger, Christian, West, Catharine M.L., and Chang-Claude, Jenny

Published
2019
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40. Genetic Variants Predict Optimal Timing of Radiotherapy to Reduce Side-effects in Breast Cancer Patients

Author

Azria, David, Brookes, Anthony, Burr, Tom, Chang-Claude, Jenny, Davidson, Susan, De Ruysscher, Dirk, Dunning, Alison, Elliott, Rebecca, Gutiérrez Enríquez, Sara, Lambin, Philippe, Rancati, Tiziana, Rosenstein, Barry, Seibold, Petra, Symonds, R. Paul, Talbot, Chris, Thierens, Hubert, Valdagni, Riccardo, Vega, Ana, Veldeman, Liv, Wenz, Frederik, Yuille, Martin, West, Catharine, Johnson, K., Chang-Claude, J., Critchley, A.-M., Kyriacou, C., Lavers, S., Rattay, T., Seibold, P., Webb, A., West, C., Symonds, R.P., and Talbot, C.J.

Published
2019
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41. Development of a Ready-to-Use Graphical Tool Based on Artificial Neural Network Classification: Application for the Prediction of Late Fecal Incontinence After Prostate Cancer Radiation Therapy

Author

Carrara, Mauro, Massari, Eleonora, Cicchetti, Alessandro, Giandini, Tommaso, Avuzzi, Barbara, Palorini, Federica, Stucchi, Claudio, Fellin, Giovanni, Gabriele, Pietro, Vavassori, Vittorio, Degli Esposti, Claudio, Cozzarini, Cesare, Pignoli, Emanuele, Fiorino, Claudio, Rancati, Tiziana, and Valdagni, Riccardo

Published
2018
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44. Patient-reported persistent symptoms after radiotherapy and association with quality of life for prostate cancer survivors.

Author

Spampinato, Sofia, Rancati, Tiziana, Waskiewicz, Justyna Magdalena, Avuzzi, Barbara, Garibaldi, Elisabetta, Faiella, Adriana, Villa, Elisa, Magli, Alessandro, Cante, Domenico, Girelli, Giuseppe, Gatti, Marco, Noris Chiorda, Barbara, Rago, Luciana, Ferrari, Paolo, Piva, Cristina, Pavarini, Maddalena, Valdagni, Riccardo, Vavassori, Vittorio, Munoz, Fernando, and Sanguineti, Giuseppe

Subjects
*CANCER patient psychology, *RESEARCH, *URINARY urge incontinence, *URINATION disorders, *HEALTH outcome assessment, *CANCER relapse, *GASTROINTESTINAL diseases, *RISK assessment, *RECTUM, *QUALITY of life, *QUESTIONNAIRES, *DESCRIPTIVE statistics, *URINARY incontinence, *CANCER fatigue, *RESEARCH funding, *RADIOTHERAPY, *URINARY organ diseases, *FECAL incontinence, *PROSTATE tumors, *LONGITUDINAL method, *DISEASE risk factors, *EVALUATION, *SYMPTOMS
Abstract

To evaluate the persistence of symptoms after radiotherapy (RT) for localised prostate cancer (PCa) and the association with quality of life (QOL). Prospective patient-reported outcome (PRO) from a multi-institutional study on PCa treated with radical RT (2010–2014) was analysed. Data was collected at baseline (BL) and follow-ups (FUPs) up to 5 years. Patients with BL and ≥3 late FUPs (≥6 months) were analysed. PRO was scored by means of the IPSS and ICIQ-SF (urinary), LENT-SOMA (gastrointestinal [GI]), and EORTC-C30 (pain, insomnia, fatigue, and QOL) questionnaires. Symptoms were defined 'persistent' if the median score over FUPs was ≥3 (urinary) or ≥2 (GI, pain, insomnia, and fatigue), and worse than BL. Different thresholds were chosen to have enough events for each symptom. QOL was linearly transformed on a continuous scale (0–100). Linear-mixed models were used to identify significant differences between groups with and without persistent symptoms including age, smoking status, previous abdominal surgery, and diabetes as confounders. Mean QOL differences between groups were evaluated longitudinally over FUPs. The analysis included 293 patients. Persistent urinary symptoms ranged from 2% (straining) to 12% (weak stream, and nocturia). Gastrointestinal symptoms ranged from 7% (rectal pain, and incontinence) to 30% (urgency). Proportions of pain, insomnia, and fatigue were 6, 13, and 18%. Significant QOL differences of small-to-medium clinical relevance were found for urinary incontinence, frequency, urgency, and nocturia. Among GI symptoms, rectal pain and incontinence showed small-to-medium differences. Fatigue was associated with the largest differences. The analysis showed that symptoms after RT for PCa occur with different persistence and their association with QOL varies in magnitude. A number of persistent urinary and GI symptoms showed differences in a comparable range. Urinary incontinence and frequency, rectal pain, and faecal incontinence more often had significant associations. Fatigue was also prevalent and associated with largely deteriorated QOL. [ABSTRACT FROM AUTHOR]

Published
2023
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45. (Pre)treatment risk factors for late fatigue and fatigue trajectories following radiotherapy for breast cancer.

Author

Rosas, Juan C., Aguado‐Barrera, Miguel E., Azria, David, Briers, Erik, Elliott, Rebecca, Farcy‐Jacquet, Marie‐Pierre, Giraldo, Alexandra, Gutiérrez‐Enríquez, Sara, Rancati, Tiziana, Rattay, Tim, Reyes, Victoria, Rosenstein, Barry, De Ruysscher, Dirk, Sperk, Elena, Stobart, Hilary, Talbot, Christopher, Vega, Ana, Taboada‐Valladares, Begoña, Veldeman, Liv, and Ward, Tim

Subjects
CANCER fatigue, FATIGUE (Physiology), BREAST cancer, POSTTRAUMATIC growth, CANCER radiotherapy, HORMONE therapy
Abstract

Fatigue is common in breast‐cancer survivors. Our study assessed fatigue longitudinally in breast cancer patients receiving adjuvant radiotherapy (RT) and aimed to identify risk factors associated with long‐term fatigue and underlying fatigue trajectories. Fatigue was measured in a prospective multicenter cohort (REQUITE) using the Multidimensional Fatigue Inventory (MFI‐20) and analyzed using mixed models. Multivariable logistic models identified factors associated with fatigue dimensions at 2 years post‐RT and latent class growth analysis identified individual fatigue trajectories. A total of 1443, 1302, 1203 and 1098 patients completed the MFI‐20 at baseline, end of RT, after 1 and 2 years. Overall, levels of fatigue significantly increased from baseline to end of RT for all fatigue dimensions (P <.05) and returned to baseline levels after 2 years. A quarter of patients were assigned to latent trajectory high (23.7%) and moderate (24.8%) fatigue classes, while 46.3% and 5.2% to the low and decreasing fatigue classes, respectively. Factors associated with multiple fatigue dimensions at 2 years include age, BMI, global health status, insomnia, pain, dyspnea and depression. Fatigue present at baseline was consistently associated with all five MFI‐20 fatigue dimensions (ORGeneralFatigue = 3.81, P <.001). From latent trajectory analysis, patients with a combination of factors such as pain, insomnia, depression, younger age and endocrine therapy had a particularly high risk of developing early and persistent high fatigue years after treatment. Our results confirmed the multidimensional nature of fatigue and will help clinicians identify breast cancer patients at higher risk of having persistent/late fatigue so that tailored interventions can be delivered. [ABSTRACT FROM AUTHOR]

Published
2023
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46. Stability of Multi-Parametric Prostate MRI Radiomic Features to Variations in Segmentation

Author

Thulasi Seetha, Sithin, primary, Garanzini, Enrico, additional, Tenconi, Chiara, additional, Marenghi, Cristina, additional, Avuzzi, Barbara, additional, Catanzaro, Mario, additional, Stagni, Silvia, additional, Villa, Sergio, additional, Chiorda, Barbara Noris, additional, Badenchini, Fabio, additional, Bertocchi, Elena, additional, Sanduleanu, Sebastian, additional, Pignoli, Emanuele, additional, Procopio, Giuseppe, additional, Valdagni, Riccardo, additional, Rancati, Tiziana, additional, Nicolai, Nicola, additional, and Messina, Antonella, additional

Published
2023
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47. Reply to: Comments on "(Pre)treatment risk factors for late fatigue and fatigue trajectories following radiotherapy for breast cancer".

Author

Rosas, Juan C., Aguado‐Barrera, Miguel E., Azria, David, Briers, Erik, Elliott, Rebecca, Farcy‐Jacquet, Marie‐Pierre, Giraldo, Alexandra, Gutiérrez‐Enríquez, Sara, Rancati, Tiziana, Rattay, Tim, Reyes, Victoria, Rosenstein, Barry, De Ruysscher, Dirk, Sperk, Elena, Stobart, Hilary, Talbot, Christopher, Vega, Ana, Taboada‐Valladares, Begoña, Veldeman, Liv, and Ward, Tim

Subjects
FATIGUE (Physiology), BREAST cancer, CANCER radiotherapy, CANCER fatigue, CANCER patients
Abstract

This document is a reply to comments on a previously published paper about the risk factors for fatigue in breast cancer patients who have undergone radiotherapy. The authors explain that they focused on late fatigue because there is a lack of understanding about this aspect of fatigue in breast cancer patients. They also address concerns about missing data and attrition rates in their study, stating that mortality did not substantially influence the attrition rate. The authors express gratitude for the opportunity to discuss their research and express interest in future collaborations to further understand fatigue in breast cancer patients. [Extracted from the article]

Published
2024
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49. Patient-reported intestinal toxicity from whole pelvis intensity-modulated radiotherapy: First quantification of bowel dose–volume effects

Author

Sini, Carla, Noris Chiorda, Barbara, Gabriele, Pietro, Sanguineti, Giuseppe, Morlino, Sara, Badenchini, Fabio, Cante, Domenico, Carillo, Viviana, Gaetano, Marcella, Giandini, Tommaso, Landoni, Valeria, Maggio, Angelo, Perna, Lucia, Petrucci, Edoardo, Sacco, Vincenzo, Valdagni, Riccardo, Rancati, Tiziana, Fiorino, Claudio, and Cozzarini, Cesare

Published
2017
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50. Cardiac Disease in Childhood Cancer Survivors Treated With Radiation Therapy: A PENTEC Comprehensive Review

Author

Bates, James E., primary, Rancati, Tiziana, additional, Keshavarz, Homa, additional, Gagliardi, Giovanna, additional, Aznar, Marianne C., additional, Howell, Rebecca M., additional, Shrestha, Suman, additional, Moiseenko, Vitali, additional, Yorke, Ellen, additional, Armenian, Saro, additional, Kremer, Leontien, additional, Chen, Ming Hui, additional, van der Pal, Helena J., additional, Cutter, David J., additional, Constine, Louis S., additional, and Hodgson, David, additional

Published
2023
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