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328 results on '"Rangelova, Elena"'

1. Toward a new paradigm of care: a surgical leaders’ Delphi consensus on the organizational factors of the new pancreas units (E-AHPBA PUECOF study)

Author

Cobianchi, Lorenzo, Dal Mas, Francesca, Abu Hilal, Mohammad, Adham, Mustapha, Alfieri, Sergio, Balzano, Gianpaolo, Barauskas, Giedrius, Bassi, Claudio, Besselink, Marc G., Bockhorn, Maximilian, Boggi, Ugo, Conlon, Kevin C., Coppola, Roberto, Dervenis, Christos, Dokmak, Safi, Falconi, Massimo, Fusai, Giuseppe Kito, Gumbs, Andrew A., Ivanecz, Arpad, Memeo, Riccardo, Radenković, Dejan, Ramia, Jose M., Rangelova, Elena, Salvia, Roberto, Sauvanet, Alain, Serrablo, Alejandro, Siriwardena, Ajith K., Stättner, Stefan, Strobel, Oliver, Zerbi, Alessandro, Malleo, Giuseppe, Butturini, Giovanni, and Frigerio, Isabella

Published
2024
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2. Consensus Statement on the Use of Near-Infrared Fluorescence Imaging during Pancreatic Cancer Surgery Based on a Delphi Study: Surgeons’ Perspectives on Current Use and Future Recommendations

Author

de Muynck, Lysanne DAN, White, Kevin P, Alseidi, Adnan, Bannone, Elisa, Boni, Luigi, Bouvet, Michael, Falconi, Massimo, Fuchs, Hans F, Ghadimi, Michael, Gockel, Ines, Hackert, Thilo, Ishizawa, Takeaki, Kang, Chang Moo, Kokudo, Norihiro, Nickel, Felix, Partelli, Stefano, Rangelova, Elena, Swijnenburg, Rutger Jan, Dip, Fernando, Rosenthal, Raul J, Vahrmeijer, Alexander L, and Mieog, J Sven D

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Pancreatic Cancer, Rare Diseases, Cancer, Digestive Diseases, fluorescence-guided surgery, intraoperative imaging, pancreatic cancer, cancer surgery, near-infrared fluorescence, indocyanine green, consensus, Delphi, Oncology and carcinogenesis
Abstract

Indocyanine green (ICG) is one of the only clinically approved near-infrared (NIR) fluorophores used during fluorescence-guided surgery (FGS), but it lacks tumor specificity for pancreatic ductal adenocarcinoma (PDAC). Several tumor-targeted fluorescent probes have been evaluated in PDAC patients, yet no uniformity or consensus exists among the surgical community on the current and future needs of FGS during PDAC surgery. In this first-published consensus report on FGS for PDAC, expert opinions were gathered on current use and future recommendations from surgeons' perspectives. A Delphi survey was conducted among international FGS experts via Google Forms. Experts were asked to anonymously vote on 76 statements, with ≥70% agreement considered consensus and ≥80% participation/statement considered vote robustness. Consensus was reached for 61/76 statements. All statements were considered robust. All experts agreed that FGS is safe with few drawbacks during PDAC surgery, but that it should not yet be implemented routinely for tumor identification due to a lack of PDAC-specific NIR tracers and insufficient evidence proving FGS's benefit over standard methods. However, aside from tumor imaging, surgeons suggest they would benefit from visualizing vasculature and surrounding anatomy with ICG during PDAC surgery. Future research could also benefit from identifying neuroendocrine tumors. More research focusing on standardization and combining tumor identification and vital-structure imaging would greatly improve FGS's use during PDAC surgery.

Published
2023

3. REDISCOVER International Guidelines on the Perioperative Care of Surgical Patients With Borderline-resectable and Locally Advanced Pancreatic Cancer

Author

Boggi, Ugo, Kauffmann, Emanuele, Napoli, Niccolò, Barreto, S. George, Besselink, Marc G., Fusai, Giuseppe K., Hackert, Thilo, Abu Hilal, Mohammad, Marchegiani, Giovanni, Salvia, Roberto, Shrikhande, Shailesh V., Truty, Mark, Werner, Jens, Wolfgang, Christopher L., Bannone, Elisa, Capretti, Giovanni, Cattelani, Alice, Coppola, Alessandro, Cucchetti, Alessandro, De Sio, Davide, Di Dato, Armando, Di Meo, Giovanna, Fiorillo, Claudio, Gianfaldoni, Cesare, Ginesini, Michael, Hidalgo Salinas, Camila, Lai, Quirino, Miccoli, Mario, Montorsi, Roberto, Pagnanelli, Michele, Poli, Andrea, Ricci, Claudio, Sucameli, Francesco, Tamburrino, Domenico, Viti, Virginia, Addeo, Pietro F., Alfieri, Sergio, Bachellier, Philippe, Baiocchi, Gian Luca, Balzano, Gianpaolo, Barbarello, Linda, Brolese, Alberto, Busquets, Juli, Butturini, Giovanni, Caniglia, Fabio, Caputo, Damiano, Casadei, Riccardo, Chunhua, Xi, Colangelo, Ettore, Coratti, Andrea, Costa, Francesca, Crafa, Francesco, Dalla Valle, Raffaele, De Carlis, Luciano, de Wilde, Roeland F., Del Chiaro, Marco, Di Benedetto, Fabrizio, Di Sebastiano, Pierluigi, Dokmak, Safi, Hogg, Melissa, Egorov, Vyacheslav I., Ercolani, Giorgio, Ettorre, Giuseppe Maria, Falconi, Massimo, Ferrari, Giovanni, Ferrero, Alessandro, Filauro, Marco, Giardino, Alessandro, Grazi, Gian Luca, Gruttadauria, Salvatore, Izbicki, Jakob R, Jovine, Elio, Katz, Matthew, Keck, Tobias, Khatkov, Igor, Kiguchi, Gozo, Kooby, David, Lang, Hauke, Lombardo, Carlo, Malleo, Giuseppe, Massani, Marco, Mazzaferro, Vincenzo, Memeo, Riccardo, Miao, Yi, Mishima, Kohei, Molino, Carlo, Nagakawa, Yuichi, Nakamura, Masafumi, Nardo, Bruno, Panaro, Fabrizio, Pasquali, Claudio, Perrone, Vittorio, Rangelova, Elena, Liu, Rong, Romagnoli, Renato, Romito, Raffaele, Rosso, Edoardo, Schulick, Richard, Siriwardena, Ajith, Spampinato, Marcello Giuseppe, Strobel, Oliver, Testini, Mario, Troisi, Roberto Ivan, Uzunoglo, Faik G., Valente, Roberto, Veneroni, Luigi, Zerbi, Alessandro, Vicente, Emilio, Vistoli, Fabio, Vivarelli, Marco, Wakabayashi, Go, Zanus, Giacomo, Zureikat, Amer, Zyromski, Nicholas J., Coppola, Roberto, D’Andrea, Vito, Davide, José, Dervenis, Christos, Frigerio, Isabella, Konlon, Kevin C., Michelassi, Fabrizio, Montorsi, Marco, Nealon, William, Portolani, Nazario, Sousa Silva, Donzília, Bozzi, Giuseppe, Ferrari, Viviana, Trivella, Maria G., Cameron, John, Clavien, Pierre-Alain, Asbun, Horacio J., Boraschi, Piero, Campani, Daniela, Cappelli, Carla, Cioni, Roberto, Dominici, Massimo, Esposito, Irene, Gambacorta, Maria A, Marciano, Emanuele, Masi, Gianluca, Morganti, Alessio, Mutignani, Massimiliano, Neri, Emanuele, Paiar, Fabiola, Reni, Michele, Rotondo, Maria Isabella, Silvestris, Nicola, Tortora, Giampaolo, Vasile, Enrico, and Volterrani, Duccio

Published
2024
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4. FOLFIRINOX or Gemcitabine-based Chemotherapy for Borderline Resectable and Locally Advanced Pancreatic Cancer: A Multi-institutional, Patient-Level, Meta-analysis and Systematic Review

Author

Eshmuminov, Dilmurodjon, Aminjonov, Botirjon, Palm, Russell F., Malleo, Giuseppe, Schmocker, Ryan K., Abdallah, Raëf, Yoo, Changhoon, Shaib, Walid L., Schneider, Marcel André, Rangelova, Elena, Choi, Yoo Jin, Kim, Hongbeom, Rose, J. Bart, Patel, Sameer, Wilson, Gregory C., Maloney, Sarah, Timmermann, Lea, Sahora, Klaus, Rössler, Fabian, Lopez-Lopez, Víctor, Boyer, Emanuel, Maggino, Laura, Malinka, Thomas, Park, Jeong Youp, Katz, Matthew H. G., Prakash, Laura, Ahmad, Syed A., Helton, Scott, Jang, Jin-Young, Hoffe, Sarah E., Salvia, Roberto, Taieb, Julien, He, Jin, Clavien, Pierre-Alain, Held, Ulrike, and Lehmann, Kuno

Published
2023
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5. Neoadjuvant FOLFIRINOX versus upfront surgery for resectable pancreatic head cancer (NORPACT-1): a multicentre, randomised, phase 2 trial

Author

Aahlin, Eirik Kjus, Bratthäll, Charlotte, Halimi, Asif, Hatlevoll, Ingunn, Heby, Margareta, Kokkola, Arto, Kordes, Maximilian, Lindblad, Stina, Lundgren, Linda, Mortensen, Michael Bau, Mortensen, Kim Erlend, Persson, Jan, Rangelova, Elena, Rønne, Elin, Sandvik, Oddvar Mathias, Søreide, Jon Arne, Vilhav, Caroline, Waardal, Kim, Wennerblom, Johanna, Williamsson, Caroline, Yaqub, Sheraz, Labori, Knut Jørgen, Bratlie, Svein Olav, Andersson, Bodil, Angelsen, Jon-Helge, Biörserud, Christina, Björnsson, Bergthor, Bringeland, Erling Audun, Elander, Nils, Garresori, Herish, Grønbech, Jon Erik, Haux, Johan, Hemmingsson, Oskar, Liljefors, Maria Gustafsson, Myklebust, Tor Åge, Nymo, Linn Såve, Peltola, Katriina, Pfeiffer, Per, Sallinen, Ville, Sandström, Per, Sparrelid, Ernesto, Stenvold, Helge, Søreide, Kjetil, Tingstedt, Bobby, Verbeke, Caroline, Öhlund, Daniel, Klint, Leif, Dueland, Svein, and Lassen, Kristoffer

Published
2024
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6. Hepatocellular carcinoma

Author

Dopazo, Cristina, Søreide, Kjetil, Rangelova, Elena, Mieog, Sven, Carrion-Alvarez, Lucia, Diaz-Nieto, Rafael, Primavesi, Florian, and Stättner, Stefan

Published
2024
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7. Surgical and Oncological Outcomes After Preoperative FOLFIRINOX Chemotherapy in Resected Pancreatic Cancer: An International Multicenter Cohort Study

Author

van Veldhuisen, Eran, Klompmaker, Sjors, Janssen, Quisette P., Hilal, Mohammed Abu, Alseidi, Adnan, Balduzzi, Alberto, Balzano, Gianpaolo, Bassi, Claudio, Berrevoet, Frederik, Bonds, Morgan, Busch, Olivier R., Butturini, Giovanni, Conlon, Kevin C., Frigerio, Isabella M., Fusai, Giuseppe K., Gagnière, Johan, Griffin, Oonagh, Hackert, Thilo, Halimi, Asif, Keck, Tobias, Kleeff, Jörg, Klaiber, Ulla, Labori, Knut J., Lesurtel, Mickael, Malleo, Giuseppe, Marino, Marco V., Molenaar, I. Quintus, Mortensen, Michael B., Nikov, Andrej, Pagnanelli, Michele, Pandé, Rupaly, Pfeiffer, Per, Pietrasz, Daniel, Rangelova, Elena, Roberts, Keith J., Cunha, Antonio Sa, Salvia, Roberto, Strobel, Oliver, Tarvainen, Timo, Wilmink, Johanna W., Koerkamp, Bas Groot, and Besselink, Marc G.

Published
2023
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8. ASO Visual Abstract: FOLFIRINOX or Gemcitabine Based Chemotherapy for Borderline Resectable and Locally Advanced Pancreatic Cancer: A Multi-Institutional, Patient-Level Meta-Analysis and Systematic Review

Author

Eshmuminov, Dilmurodjon, Aminjonov, Botirjon, Palm, Russell F., Malleo, Giuseppe, Schmocker, Ryan K., Abdallah, Raëf, Yoo, Changhoon, Shaib, Walid L., Schneider, Marcel André, Rangelova, Elena, Choi, Yoo Jin, Kim, Hongbeom, Rose, J. Bart, Patel, Sameer, Wilson, Gregory C., Maloney, Sarah, Timmermann, Lea, Sahora, Klaus, Rössler, Fabian, Lopez-Lopez, Víctor, Boyer, Emanuel, Maggino, Laura, Malinka, Thomas, Park, Jeong Youp, Katz, Matthew H. G., Prakash, Laura, Ahmad, Syed A., Helton, Scott, Jang, Jin-Young, Hoffe, Sarah E., Salvia, Roberto, Taieb, Julien, He, Jin, Clavien, Pierre-Alain, Held, Ulrike, and Lehmann, Kuno

Published
2023
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10. Development of biotissue training models for anastomotic suturing in pancreatic surgery

Author

Karadza, Emir, Haney, Caelan M., Limen, Eldridge F., Müller, Philip C., Kowalewski, Karl-Friedrich, Sandini, Marta, Wennberg, Erica, Schmidt, Mona W., Felinska, Eleni A., Lang, Franziska, Salg, Gabriel, Kenngott, Hannes G., Rangelova, Elena, Mieog, Sven, Vissers, Frederique, Korrel, Maarten, Zwart, Maurice, Sauvanet, Alain, Loos, Martin, Mehrabi, Arianeb, de Santibanes, Martin, Shrikhande, Shailesh V., Abu Hilal, Mohammad, Besselink, Marc G., Müller-Stich, Beat P., Hackert, Thilo, and Nickel, Felix

Published
2023
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11. Lumen apposing metal stents vs. double pigtail plastic stents for the drainage of pancreatic walled-off necrosis

Author

VALENTE, Roberto, primary, ZARANTONELLO, Laura, additional, DEL CHIARO, Marco, additional, VUJASINOVIC, Miroslav, additional, BALDAQUE-SILVA, Francisco, additional, SCANDAVINI, Chiara M., additional, RANGELOVA, Elena, additional, VESPASIANO, Francesca, additional, ANZILLOTTI, Giuseppe, additional, LÖHR, Johannes M., additional, and ARNELO, Urban, additional

Published
2024
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23. Hepatocellular carcinoma

Author

Dopazo, Cristina, primary, Søreide, Kjetil, additional, Rangelova, Elena, additional, Mieog, Sven, additional, Carrion-Alvarez, Lucia, additional, Diaz-Nieto, Rafael, additional, Primavesi, Florian, additional, and Stättner, Stefan, additional

Published
2023
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34. Neoadjuvant FOLFIRINOX versus upfront surgery for resectable pancreatic head cancer (NORPACT-1): a multicentre, randomised, phase 2 trial

Author

Labori, Knut Jørgen, Bratlie, Svein Olav, Andersson, Bodil, Angelsen, Jon-Helge, Biörserud, Christina, Björnsson, Bergthor, Bringeland, Erling Audun, Elander, Nils, Garresori, Herish, Grønbech, Jon Erik, Haux, Johan, Hemmingsson, Oskar, Liljefors, Maria Gustafsson, Myklebust, Tor Åge, Nymo, Linn Såve, Peltola, Katriina, Pfeiffer, Per, Sallinen, Ville, Sandström, Per, Sparrelid, Ernesto, Stenvold, Helge, Søreide, Kjetil, Tingstedt, Bobby, Verbeke, Caroline, Öhlund, Daniel, Klint, Leif, Dueland, Svein, Lassen, Kristoffer, Aahlin, Eirik Kjus, Bratthäll, Charlotte, Halimi, Asif, Hatlevoll, Ingunn, Heby, Margareta, Kokkola, Arto, Kordes, Maximilian, Lindblad, Stina, Lundgren, Linda, Mortensen, Michael Bau, Mortensen, Kim Erlend, Persson, Jan, Rangelova, Elena, Rønne, Elin, Sandvik, Oddvar Mathias, Søreide, Jon Arne, Vilhav, Caroline, Waardal, Kim, Wennerblom, Johanna, Williamsson, Caroline, and Yaqub, Sheraz

Abstract

In patients undergoing resection for pancreatic cancer, adjuvant modified fluorouracil, leucovorin, irinotecan, and oxaliplatin (FOLFIRINOX) improves overall survival compared with alternative chemotherapy regimens. We aimed to compare the efficacy and safety of neoadjuvant FOLFIRINOX with the standard strategy of upfront surgery in patients with resectable pancreatic ductal adenocarcinoma.

Published
2024
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36. Pancreatic cancer

Author

Søreide, Kjetil, primary, Rangelova, Elena, additional, Dopazo, Christina, additional, Mieog, Sven, additional, and Stättner, Stefan, additional

Published
2023
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37. T-Cell Therapy: Options for Infectious Diseases

Author

Parida, Shreemanta K., Poiret, Thomas, Zhenjiang, Liu, Meng, Qingda, Heyckendorf, Jan, Lange, Christoph, Ambati, Aditya S., Rao, Martin V., Valentini, Davide, Ferrara, Giovanni, Rangelova, Elena, Dodoo, Ernest, Zumla, Alimuddin, and Maeurer, Markus

Published
2015

46. Impact of Personal Protective Equipment on Surgical Performance During the COVID-19 Pandemic

Author

Yánez Benítez, Carlos, Güemes, Antonio, Aranda, José, Ribeiro, Marcelo, Ottolino, Pablo, Di Saverio, Salomone, Alexandrino, Henrique, Ponchietti, Luca, Blas, Juan L, International Cooperation Group on PPE and Emergency Surgery, Ramos, Juan Pablo, Rangelova, Elena, Muñoz, Mercedes, and Yánez, Carlos

Subjects
Adult, Male, medicine.medical_specialty, Original Scientific Report, Coronavirus disease 2019 (COVID-19), Betacoronavirus, Clinical Decision-Making, Coronavirus Infections, Fatigue, Female, Humans, Middle Aged, Pandemics, Pneumonia, Viral, Surveys and Questionnaires, Attitude of Health Personnel, Personal Protective Equipment, Surgeons, Work Performance, education, Visual impairment, 030230 surgery, Affect (psychology), 03 medical and health sciences, 0302 clinical medicine, Pandemic, Medicine, Viral, Personal protective equipment, SARS-CoV-2, business.industry, COVID-19, Pneumonia, Vascular surgery, medicine.disease, Cardiothoracic surgery, 030220 oncology & carcinogenesis, Surgery, Medical emergency, medicine.symptom, business, Abdominal surgery
Abstract

Background The Severe Acute Respiratory Syndrome Coronavirus 2 pandemic has exposed surgeons to hazardous working conditions, imposing the need for personal protective equipment (PPE) use during surgery. The use of such equipment may affect their non-technical skills, augment fatigue, and affect performance. This study aimed to assess the surgeons’ perceptions of the impact of wearing PPE during emergency surgery throughout the pandemic. Methods An international cooperation group conducted an anonymous online survey among surgeons from over 30 countries, to assess perceptions about the impact of PPE use on non-technical skills, overall comfort, decision making, and surgical performance during emergency surgery on COVID-19 patients. Results Responses to the survey (134) were received from surgeons based on 26 countries. The vast majority (72%) were males. More than half of the respondents (54%) felt that their surgical performance was hampered with PPE. Visual impairment was reported by 63%, whereas 54% had communication impediments. Less than half (48%) felt protected with the use of PPE, and the same proportion perceived that the use of such equipment influenced their decision making. Decreased overall comfort was cited by 66%, and 82% experienced increased surgical fatigue. Conclusions Surgeons perceived impediment for both visibility and communication, and other non-technical skills while using PPE on emergency surgery in COVID-19 patients. Their perceived lack of protection and comfort and increased fatigue may have inhibited their optimal surgical performance. More attention should be placed in the design of more user-friendly equipment, given the possibility of a second wave of the pandemic.

Published
2020

50. Surgical and Oncological Outcomes After Preoperative FOLFIRINOX Chemotherapy in Resected Pancreatic Cancer: An International Multicenter Cohort Study

Author

van Veldhuisen, Eran, Klompmaker, Sjors, Janssen, Quisette P., Hilal, Mohammed Abu, Alseidi, Adnan, Balduzzi, Alberto, Balzano, Gianpaolo, Bassi, Claudio, Berrevoet, Frederik, Bonds, Morgan, Busch, Olivier R., Butturini, Giovanni, Conlon, Kevin C., Frigerio, Isabella M., Fusai, Giuseppe K., Gagnière, Johan, Griffin, Oonagh, Hackert, Thilo, Halimi, Asif, Keck, Tobias, Kleeff, Jörg, Klaiber, Ulla, Labori, Knut J., Lesurtel, Mickael, Malleo, Giuseppe, Marino, Marco V., Molenaar, I. Quintus, Mortensen, Michael B., Nikov, Andrej, Pagnanelli, Michele, Pandé, Rupaly, Pfeiffer, Per, Pietrasz, Daniel, Rangelova, Elena, Roberts, Keith J., Cunha, Antonio Sa, Salvia, Roberto, Strobel, Oliver, Tarvainen, Timo, Wilmink, Johanna W., Koerkamp, Bas Groot, Besselink, Marc G., Sauvanet, Alain, Marthey, Lysiane, Laurent, Christophe, Régenet, Nicolas, Coriat, Romain, Taieb, Julien, Turini, Olivier, Graduate School, Surgery, CCA - Cancer Treatment and Quality of Life, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, Oncology, CCA - Cancer biology and immunology, CCA - Imaging and biomarkers, Internal medicine, University of Helsinki, Clinicum, HUS Abdominal Center, and II kirurgian klinikka

Subjects
Complications, LAPC, Folfrinox, OS, Folfrinox, BRPC, LAPC, OS, Definition, Classification, 3126 Surgery, anesthesiology, intensive care, radiology, Gemcitabine, SDG 3 - Good Health and Well-being, Oncology, Medicine and Health Sciences, Surgery, BRPC
Abstract

Background Preoperative FOLFIRINOX chemotherapy is increasingly administered to patients with borderline resectable (BRPC) and locally advanced pancreatic cancer (LAPC) to improve overall survival (OS). Multicenter studies reporting on the impact from the number of preoperative cycles and the use of adjuvant chemotherapy in relation to outcomes in this setting are lacking. This study aimed to assess the outcome of pancreatectomy after preoperative FOLFIRINOX, including predictors of OS. Methods This international multicenter retrospective cohort study included patients from 31 centers in 19 European countries and the United States undergoing pancreatectomy after preoperative FOLFIRINOX chemotherapy (2012–2016). The primary end point was OS from diagnosis. Survival was assessed using Kaplan-Meier analysis and Cox regression. Results The study included 423 patients who underwent pancreatectomy after a median of six (IQR 5–8) preoperative cycles of FOLFIRINOX. Postoperative major morbidity occurred for 88 (20.8%) patients and 90-day mortality for 12 (2.8%) patients. An R0 resection was achieved for 243 (57.4%) patients, and 259 (61.2%) patients received adjuvant chemotherapy. The median OS was 38 months (95% confidence interval [CI] 34–42 months) for BRPC and 33 months (95% CI 27–45 months) for LAPC. Overall survival was significantly associated with R0 resection (hazard ratio [HR] 1.63; 95% CI 1.20–2.20) and tumor differentiation (HR 1.43; 95% CI 1.08–1.91). Neither the number of preoperative chemotherapy cycles nor the use adjuvant chemotherapy was associated with OS. Conclusions This international multicenter study found that pancreatectomy after FOLFIRINOX chemotherapy is associated with favorable outcomes for patients with BRPC and those with LAPC. Future studies should confirm that the number of neoadjuvant cycles and the use adjuvant chemotherapy have no relation to OS after resection.

Published
2021

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