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3. Performance Analysis of 24-Tupled RoF System Based on Parallel MZMs and SOA

Author

Singh, Sonam, Rani, Ankita, Kedia, Deepak, Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, Singh, Sri Niwas, editor, Mahanta, Saurov, editor, and Singh, Yumnam Jayanta, editor

Published
2023
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8. A machine learning-based approach to determine infection status in recipients of BBV152 (Covaxin) whole-virion inactivated SARS-CoV-2 vaccine for serological surveys

Author

Singh, Prateek, Ujjainiya, Rajat, Prakash, Satyartha, Naushin, Salwa, Sardana, Viren, Bhatheja, Nitin, Singh, Ajay Pratap, Barman, Joydeb, Kumar, Kartik, Gayali, Saurabh, Khan, Raju, Rawat, Birendra Singh, Tallapaka, Karthik Bharadwaj, Anumalla, Mahesh, Lahiri, Amit, Kar, Susanta, Bhosale, Vivek, Srivastava, Mrigank, Mugale, Madhav Nilakanth, Pandey, C.P., Khan, Shaziya, Katiyar, Shivani, Raj, Desh, Ishteyaque, Sharmeen, Khanka, Sonu, Rani, Ankita, Promila, Sharma, Jyotsna, Seth, Anuradha, Dutta, Mukul, Saurabh, Nishant, Veerapandian, Murugan, Venkatachalam, Ganesh, Bansal, Deepak, Gupta, Dinesh, Halami, Prakash M., Peddha, Muthukumar Serva, Veeranna, Ravindra P., Pal, Anirban, Singh, Ranvijay Kumar, Anandasadagopan, Suresh Kumar, Karuppanan, Parimala, Rahman, Syed Nasar, Selvakumar, Gopika, Venkatesan, Subramanian, Karmakar, Malay Kumar, Sardana, Harish Kumar, Kothari, Anamika, Parihar, Devendra Singh, Thakur, Anupma, Saifi, Anas, Gupta, Naman, Singh, Yogita, Reddu, Ritu, Gautam, Rizul, Mishra, Anuj, Mishra, Avinash, Gogeri, Iranna, Rayasam, Geethavani, Padwad, Yogendra, Patial, Vikram, Hallan, Vipin, Singh, Damanpreet, Tirpude, Narendra, Chakrabarti, Partha, Maity, Sujay Krishna, Ganguly, Dipyaman, Sistla, Ramakrishna, Balthu, Narender Kumar, A, Kiran Kumar, Ranjith, Siva, Kumar, B. Vijay, Jamwal, Piyush Singh, Wali, Anshu, Ahmed, Sajad, Chouhan, Rekha, Gandhi, Sumit G., Sharma, Nancy, Rai, Garima, Irshad, Faisal, Jamwal, Vijay Lakshmi, Paddar, Masroor Ahmad, Khan, Sameer Ullah, Malik, Fayaz, Ghosh, Debashish, Thakkar, Ghanshyam, Barik, S.K., Tripathi, Prabhanshu, Satija, Yatendra Kumar, Mohanty, Sneha, Khan, Md. Tauseef, Subudhi, Umakanta, Sen, Pradip, Kumar, Rashmi, Bhardwaj, Anshu, Gupta, Pawan, Sharma, Deepak, Tuli, Amit, Ray chaudhuri, Saumya, Krishnamurthi, Srinivasan, Prakash, L., Rao, Ch V., Singh, B.N., Chaurasiya, Arvindkumar, Chaurasiyar, Meera, Bhadange, Mayuri, Likhitkar, Bhagyashree, Mohite, Sharada, Patil, Yogita, Kulkarni, Mahesh, Joshi, Rakesh, Pandya, Vaibhav, Mahajan, Sachin, Patil, Amita, Samson, Rachel, Vare, Tejas, Dharne, Mahesh, Giri, Ashok, Paranjape, Shilpa, Sastry, G. Narahari, Kalita, Jatin, Phukan, Tridip, Manna, Prasenjit, Romi, Wahengbam, Bharali, Pankaj, Ozah, Dibyajyoti, Sahu, Ravi Kumar, Dutta, Prachurjya, Singh, Moirangthem Goutam, Gogoi, Gayatri, Tapadar, Yasmin Begam, Babu, Elapavalooru VSSK., Sukumaran, Rajeev K., Nair, Aishwarya R., Puthiyamadam, Anoop, Valappil, Prajeesh Kooloth, Pillai Prasannakumari, Adrash Velayudhan, Chodankar, Kalpana, Damare, Samir, Agrawal, Ved Varun, Chaudhary, Kumardeep, Agrawal, Anurag, Sengupta, Shantanu, and Dash, Debasis

Published
2022
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12. Assessment of Health Care Techniques in IoT

Author

Diwaker, Chander, Jangra, Ajay, Rani, Ankita, Bansal, Jagdish Chand, Series Editor, Deep, Kusum, Series Editor, Nagar, Atulya K., Series Editor, Jain, Shruti, editor, Sood, Meenakshi, editor, and Paul, Sudip, editor

Published
2020
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19. Contributors

Author

Abdul Halip, Juliana, primary, Abdul Khalil, H.P.S., additional, Abdullah, E.C., additional, Ahmad, Zakiah, additional, Amalraj, Augustine, additional, Baker, Syed, additional, Bezgin Carbas, Buket, additional, Cevik, Emre, additional, Chin, Kit Ling, additional, Chouhan, Raghuraj Singh, additional, Chua, Han Bing, additional, Čupić, Željko, additional, Dolatabadi, Jafar Ezzati Nazhad, additional, Gao, Lihong, additional, Ghaffari, Maryam, additional, Gopakumar, Deepu A., additional, Gopi, Sreeraj, additional, Grohens, Yves, additional, Hedenqvist, Mikael S., additional, Jesionek, Marcin, additional, Jude, Shintu, additional, Kangas, Heli, additional, Karri, Rama Rao, additional, Khalid, Mohammad, additional, Khan, Fahad Saleem Ahmed, additional, Kuila, Aneek, additional, Langton, Maud, additional, Lau, Yien Jun, additional, Lau, Sie Yon, additional, Lee, Seng Hua, additional, Lendel, Christofer, additional, Leong, Kah Hon, additional, Lončarević, Davor, additional, Lum, Wei Chen, additional, Mehdinia, Ali, additional, Mehrabi, Hossein, additional, Mishra, Nirmalendu Sekhar, additional, Mistewicz, Krystian, additional, Mubarak, N.M., additional, Nasiri, Noushin, additional, Nawaz, Ahmad, additional, Nowak, Marian, additional, Olsson, Richard T., additional, Pitkänen, Marja, additional, Poothanari, Mohammed Arif, additional, Pottathara, Yasir Beeran, additional, Prasad, Nagendra, additional, Qi, Xianghui, additional, Rani, Ankita, additional, Sabu, K.T., additional, Sahu, J.N., additional, Saravanan, Pichiah, additional, Satish, Sreedharamurthy, additional, Shams, Shahriar, additional, Sim, Lan Ching, additional, Sukumaran, Nimisha Pulikkal, additional, Thomas, Sabu, additional, Tricoli, Antonio, additional, Wang, Shujun, additional, Ye, Xinchen, additional, Yildiz, Huseyin Bekir, additional, and Zabed, H., additional

Published
2019
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23. Quinolinyl β-enaminone derivatives exhibit leishmanicidal activity against Leishmania donovani by impairing the mitochondrial electron transport chain complex and inducing ROS-mediated programmed cell death

Author

Rani, Ankita, primary, Khanikar, Shilpika, additional, Dutta, Mukul, additional, Katiyar, Shivani, additional, Qamar, Tooba, additional, Seth, Anuradha, additional, Agnihotri, P K, additional, Guha, Rajdeep, additional, Vishwakarma, Jai N, additional, and Kar, Susanta, additional

Published
2022
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27. Discovery of 2,3-dihydro-1H-pyrrolo[3,4-b]quinolin-1-one derivatives as possible antileishmanial agents

Author

Seth, Anuradha, primary, Ghoshal, Anirban, additional, Dewaker, Varun, additional, Rani, Ankita, additional, Singh, Sangh Priya, additional, Dutta, Mukul, additional, Katiyar, Shivani, additional, Singh, Sandeep Kumar, additional, Rashid, Mamunur, additional, Wahajuddin, Muhammad, additional, Kar, Susanta, additional, and Srivastava, Ajay Kumar, additional

Published
2022
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28. Quinolinyl β-enaminone derivatives exhibit leishmanicidal activity against Leishmania donovani by impairing the mitochondrial electron transport chain complex and inducing ROS-mediated programmed cell death.

Author

Rani, Ankita, Khanikar, Shilpika, Dutta, Mukul, Katiyar, Shivani, Qamar, Tooba, Seth, Anuradha, Agnihotri, P K, Guha, Rajdeep, Vishwakarma, Jai N, and Kar, Susanta

Subjects
*LEISHMANIA donovani, *APOPTOSIS, *LEISHMANIA, *ELECTRON transport, *VISCERAL leishmaniasis, *MITOCHONDRIA
Abstract

Objectives Previously, a series of side chain-modified quinolinyl β-enaminones was identified to possess significant activity against chloroquine-sensitive or -resistant Plasmodium falciparum and Brugia malayi microfilariae. The present study evaluates in vitro and in vivo activity of the series against Leishmania donovani and reports their mode of action. Methods The in vitro activity of 15 quinolinyl β-enaminone derivatives against Leishmania promastigotes and amastigotes was assessed by luciferase assay. The reduction of organ parasite burden was assessed by Giemsa staining in L. donovani -infected BALB/c mice and hamsters. Intracellular Ca2+ and ATP level in active derivative (3D)-treated promastigotes were determined by fluorescence and luminescence assays. Flow cytometry was performed to determine loss of mitochondrial membrane potential (MMP) using JC-1 dye, reactive oxygen species (ROS) generation using 2′,7′-dichlorodihydrofluorescein diacetate (DCFDA) dye, phosphatidylserine externalization by Annexin V-FITC staining and cell-cycle arrest by propidium iodide (PI) staining. Results Compounds 3A, 3B and 3D showed significant in vitro efficacy against L. donovani with IC50 < 6 µM and mild cytotoxicity (∼75% viability) at 25 µM on J774 macrophages. 3A and 3D at 50 mg/kg and 100 mg/kg reduced parasite burden (>84%) in infected mice and hamsters, respectively, whereas 3D-treated animals demonstrated maximum parasite burden reduction without organ toxicity. Mode-of-action analysis revealed that 3D induced apoptosis by inhibiting mitochondrial complex II, reducing MMP and ATP levels, increasing ROS and Ca2+ levels, ultimately triggering phosphatidylserine externalization and sub-G0/G1 cell-cycle arrest in promastigotes. Conclusions Compound 3D-mediated inhibition of L. donovani mitochondrial complex induces apoptosis, making it a promising therapeutic candidate for visceral leishmaniasis. [ABSTRACT FROM AUTHOR]

Published
2023
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30. List of contributors

Author

Aggrawal, Ritu, Aigberua, Ayobami Omozemoje, Barbhuiya, Sweety Nath, Barhoi, Dharmeswar, Bauddh, Kuldeep, Borah, Preetismita, Bordoloi, Nirmali, Chattaraj, Sudipta, Daripa, Amrita, Dua, Kamal, Dwivedi, Himanshu, Garg, Shriya, Gauns, Mangesh, Giri, Ajay, Giri, Deen Dayal, Giri, Sarbani, Grewal, Ajmer Singh, Iniaghe, Paschal Okiroro, Izah, Sylvester Chibueze, Jigyasu, Dharmendra Kumar, Kashyap, Deepak, Kaur, Gagandeep, Kaushal, Jyotsna, Khan, Juhi, Kharia, Sushil Kumar, Kumar, Aman, Kumar, Harshbardhan, Kumar, Lawrence, Kumar, Manish, Kumar, P. Sravan, Kumar, Pawan, Kumar, Sandeep, Kumar, Sunil, Kumari, Khushbu, Kumari, Neeta, Madhav, Sughosh, Malav, Lal Chand, Mishra, Priyanka, Mishra, Rahul, Mishra, Virendra Kumar, Mondal, Bipradeep, Mritunjay, Mukherjee, Priya, Ngun, Clement Takon, Odubo, Tamaraukepreye Catherine, Pandey, Soumya, Paswan, Sanjeet Kumar, Peyravi, Majid, Quaff, Abdur, Rachamalla, Mahesh, Rani, Ankita, Rani, Lata, Rezaei, Hossein, Sahoo, Biswa Mohan, Saravanan, Pichiah, Sharma, Anjali, Sharma, Devkant, Sharma, Uttkarshni, Sharma, Vaishali, Shukla, Sushil Kumar, Singh, Akshay Kumar, Singh, Bhaskar, Singh, Ekta, Singh, Gurudatta, Singh, Munendra, Singh, Pardeep, Singh, Priyanka, Singh, Ram Kishore, Singh, Ravindra Pratap, Singh, Sandeep, Singh, Shobha, Srivastav, Arun Lal, Sunil, B.H., Sweta, Tiwari, Rinkey, Verma, Nitin, Yadav, Brijesh, and Yadav, Dinesh K.

Published
2023
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37. Discovery of 2,3-dihydro-1H-pyrrolo[3,4-b]quinolin-1-one derivatives as possible antileishmanial agentsElectronic supplementary information (ESI) available. See DOI: https://doi.org/10.1039/d2md00078d

Author

Seth, Anuradha, Ghoshal, Anirban, Dewaker, Varun, Rani, Ankita, Singh, Sangh Priya, Dutta, Mukul, Katiyar, Shivani, Singh, Sandeep Kumar, Rashid, Mamunur, Wahajuddin, Muhammad, Kar, Susanta, and Srivastava, Ajay Kumar

Abstract

A series of uniquely functionalized 2,3,-dihydro-1H-pyyrolo[3,4-b]quinolin-1-one derivatives were synthesized in one to two steps by utilizing a post-Ugi modification strategy and were evaluated for antileishmanial efficacy against visceral leishmaniasis (VL). Among the library compounds, compound 5mexhibited potential in vitroantileishmanial activity (CC50= 65.11 μM, SI = 7.79, anti-amastigote IC50= 8.36 μM). In vivoantileishmanial evaluation of 5mdemonstrated 56.2% inhibition in liver and 61.1% inhibition in spleen parasite burden in infected Balb/c mice (12.5 mg kg−1, i.p.). In vitropharmacokinetic study ascertained the stability of 5min both simulated gastric fluid and simulated intestinal fluid. All the active compounds passed the PAINS filter and showed no toxicity in in silicopredictions.

Published
2022
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41. List of Contributors

Author

Ahlawat, Jyoti, Ahmad, Nabeel, Ashish, Ballesteros, M. Paloma, Bharti, Shweta, Cerda, Jose R., Fernandez-Garcia, Raquel, Goel, Apoorva, Gogoi, Manashjit, Gopinath, P., Gulati, Khushboo, Haldar, Swati, Hegde, Harsha, Kumar, Alok, Kumar, Manish, Kumar, Pramod, Lahiri, Debrupa, Lalatsa, Aikaterini, Matai, Ishita, Meher, Mukesh Kumar, Mukherjee, Priya, Narayan, Mahesh, Pérez-Ballesteros, L. Fernando, Poluri, Krishna Mohan, Raj, Rocky, Rani, Ankita, Roy, Partha, Roy, Subarna, Sachdev, Abhay, Sahai, Nitin, Saravanan, Pichiah, Serrano, Dolores R., and Vinogradov, Alexandr

Published
2019
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43. Discovery of 2,3-dihydro-1 H -pyrrolo[3,4- b ]quinolin-1-one derivatives as possible antileishmanial agents.

Author

Seth A, Ghoshal A, Dewaker V, Rani A, Singh SP, Dutta M, Katiyar S, Singh SK, Rashid M, Wahajuddin M, Kar S, and Srivastava AK

Abstract

A series of uniquely functionalized 2,3,-dihydro-1 H -pyyrolo[3,4- b ]quinolin-1-one derivatives were synthesized in one to two steps by utilizing a post-Ugi modification strategy and were evaluated for antileishmanial efficacy against visceral leishmaniasis (VL). Among the library compounds, compound 5m exhibited potential in vitro antileishmanial activity (CC 50 = 65.11 μM, SI = 7.79, anti-amastigote IC 50 = 8.36 μM). In vivo antileishmanial evaluation of 5m demonstrated 56.2% inhibition in liver and 61.1% inhibition in spleen parasite burden in infected Balb/c mice (12.5 mg kg -1 , i.p.). In vitro pharmacokinetic study ascertained the stability of 5m in both simulated gastric fluid and simulated intestinal fluid. All the active compounds passed the PAINS filter and showed no toxicity in in silico predictions., Competing Interests: There are no conflicts to declare., (This journal is © The Royal Society of Chemistry.)

Published
2022
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