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Bis(indolyl)methane derivatives are efficiently synthesized from indole/2-methyl indole and aldehydes using acidic ionic liquid immobilized on magnetic Fe3O4 nanoparticles. Catalyst used in this methodology is synthesized and characterized using various techniques like FT-IR, TGA, TEM, EDX, Powdered XRD and VSM. The catalyst can be easily retrieved by an external magnet and has been reused up to five runs without any appreciable loss of its catalytic activity. [ABSTRACT FROM AUTHOR]

This work presents a microwave assisted solvent-free synthesis of N,N′-dialkyl-4-aryl-3,4-dihydropyrimidinones/thiones in the presence of Ceric Ammonium Nitrate (CAN) via direct condensation of aromatic aldehydes, β-keto ester, and N,N′-dialkylurea/thiourea. The highlights of the methodology adopted are (i) facile condensation of the reactants into product without any side-products, and (ii) short reaction time with high yield and good purity. All the compounds synthesized were characterized and established by spectroscopic techniques such as FTIR, 1H NMR, 13C NMR, and Mass. The structure of the compound is further corroborated by single crystal X-ray diffraction analysis. [ABSTRACT FROM AUTHOR]

A solvent-free synthesis of 3,4-dihydropyrimidin-2(1 H)-ones from aromatic aldehydes, β-keto ester/acetyl acetone and urea catalysed by cupric acetate under thermal condition is reported as a simple and an efficient protocol. Compared with classical Biginelli reaction reported in 1893, this new method provides much improved modification in terms of yield and reaction time. The usage of milder catalyst, environmental friendly procedures and excellent yields within a very short time (5-15 min) are the advantages of the method in which the involvement of solvent-free condition adds an edge to the method. Thus, the efficiency of the protocol enabled the rapid synthesis of 3,4 -dihydropyrimidin-2(1 H)-one derivatives in a short duration. [ABSTRACT FROM AUTHOR]

The development of a metal‐free protocol for transformations in organic synthesis offers a significant potential environmental benefit. This article reports the exploration of meglumine, a nontoxic and biodegradable amino sugar, as an organocatalyst for the synthesis of biologically active 1H‐dibenzo[b,e][1,4]diazepin‐1‐ones, highly regioselective benzimidazole derivatives and derivatives of quinoxalines. Operational simplicity, mild reaction conditions, shorter reaction times, and use of green solvents are the highlights of this protocol. The advantage of ultrasonic irradiation has been significantly explored for the synthesis of the aforesaid compounds. Furthermore, the multifaceted use of o‐phenylenediamine has also been accentuated in the study. [ABSTRACT FROM AUTHOR]