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7 results on '"Ranjana, Rashmi"'

3. Neonatal Paratesticular Scrotal Mass: A Rare Case of Atypical Neurofibromatous Neoplasm with Uncertain Biologic Potential.

Author

Srivastava, Saurav, Chaubey, Digamber, Rahul, Sandip Kumar, Thakur, Vinit Kumar, and Ranjana, Rashmi

Subjects
TUMORS, NEUROFIBROMA, NEWBORN infants, MUSCLE tumors, NEVUS
Abstract

Atypical neurofibromatous neoplasm with uncertain biologic potential presenting as a paratesticular scrotal mass in a neonate with congenital giant melanocytic nevus is rare. Only one such case of neonatal scrotal neurofibroma has been reported earlier. We report an additional case and its management. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Complicated duodenal perforation in children: Role of T-tube.

Author

Keshri, Rupesh, Chaubey, Digamber, Yadav, Ramdhani, Kumar, Vijayendra, Thakur, Vinit Kumar, Ranjana, Rashmi, and Rahul, Sandip Kumar

Subjects
BLUNT trauma, PEPTIC ulcer perforation, IATROGENIC diseases, RETROSPECTIVE studies, DUODENUM, DUODENAL ulcers, INTESTINAL perforation, ABDOMINAL injuries
Abstract

Background: Diagnosis of duodenal perforation (DP) in children is often delayed. This worsens the clinical condition and complicates simple closure.Objectives: To explore the advantages of using T-tube in surgeries for DP in children.Patients and Methods: A retrospective study was conducted on all patients of DP managed in the Department of Paediatric surgery at a tertiary centre from January 2016 to December 2020. Clinical, operative and post-operative data were collected. Patients, with closure over a T-tube to ensure tension-free healing, were critically analysed.Results: A total of nine DP patients with ages ranging from 2 years to 9 years were managed. Five (55.6%) patients had blunt abdominal trauma; a 2-year-old male had perforation following accidental ingestion of lollypop-stick while a 3-year-old male had DP during endoscopic evaluation (iatrogenic) of bleeding duodenal ulcers; cause could not be found in other 2 (22.2%) patients. Of the five patients with blunt abdominal trauma, 4 (80%) had large perforation with oedematous bowel, necessitating repair over T-tube. Both patients with unknown causes had uneventful outcomes following primary repair with Graham's patch. Patients with lollypop-stick ingestion and iatrogenic perforation did well with repair over T-tube. The only trauma patient with primary repair leaked but subsequently had successful repair over a T-tube. One patient with complete transection of the third part of the duodenum and pancreatic injury who had repair over T-tube died due to secondary haemorrhage on the 10th post-operative day.Conclusion: Closure over a T-tube in DP, presenting late with oedematous bowel, ensures low pressure at the perforation site, forms a controlled fistula and promotes healing, thereby lessening post-operative complications. [ABSTRACT FROM AUTHOR]

Published
2022
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7. Possible involvement of NF-?B in the response of cells to folate deficiency.

Author

NC DOCKS at The University of North Carolina at Greensboro, Ranjana, Rashmi, NC DOCKS at The University of North Carolina at Greensboro, and Ranjana, Rashmi

Abstract

Folate, a water soluble B vitamin, serves as a methyl donor for the synthesis of nucleotides and methionine. Folate deficiency has been linked to a variety of health problems that include developmental defects, cancer and neurological diseases. The relation between folate deficiency and human health problems has not been fully explained. Our preliminary results and limited published data have shown that the activity of NF-? B increases in folate deficient conditions. NF-?B is a cytosolic dimeric transcription factor that responds to a variety of stimuli by regulating genes involved in immune response, cell survival and cell growth. The purpose of the study was to determine if folate deficiency leads to altered NF-?B activity, protein levels and nuclear localization, and to determine the possible mechanisms behind this alteration. NIH3T3 cells containing a NF-?B reporter construct (NF-?B-LUC-3T3 cells) were grown for 7 and 11 days in folate sufficient and folate deficient DMEM medium either with or without TNF-a (stimulator of NF-?B). NF-?B activity was higher in folate deficient medium at days 7 and 11 in both unstimulated and stimulated cells, as measured by luciferase assay per unit DNA. NF-?B protein levels analyzed by Western Blot showed no difference between folate sufficient and deficient cells. Immunofluorescence by confocal microscopy showed that there was no significant change in the nuclear localization of NF-?B in folate deficient conditions even when stimulated with TNF-a. Analysis of reactive oxygen species (ROS) using a fluorescent assay with flow cytometry revealed that there was more fluorescence per cell in folate deficient cells at day 11. This increase in ROS could be one of the mechanisms behind the increase in NF-?B activity in folate deficient cells.

Published
2009

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